psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:G34	R:R:I37	3.53	No	Yes	0	3	5
2	R:R:I37	R:R:L80	9.99	Yes	Yes	0	5	8
3	R:R:I37	R:R:P81	6.77	Yes	No	0	5	9
4	R:R:F39	R:R:I324	6.28	No	No	0	5	6
5	R:R:C320	R:R:G40	3.92	No	No	0	6	8
6	R:R:G43	R:R:P323	4.06	No	No	0	9	9
7	R:R:D72	R:R:N44	6.73	Yes	Yes	0	9	9
8	R:R:N44	R:R:P323	8.15	Yes	No	0	9	9
9	R:R:P327	R:R:V47	5.3	No	No	0	7	9
10	R:R:L57	R:R:V51	10.43	No	No	0	8	8
11	R:R:V51	R:R:V66	4.81	No	No	0	8	6
12	R:R:H54	R:R:H56	3.58	No	No	0	6	6
13	R:R:H54	R:R:L57	19.28	No	No	0	6	8
14	R:R:H58	R:R:R55	4.51	No	No	0	8	7
15	R:R:H62	R:R:L57	28.28	No	No	0	8	8
16	R:R:H62	R:R:S59	5.58	No	No	0	8	7
17	R:R:V60	R:R:Y64	7.57	No	Yes	0	7	8
18	R:R:V138	R:R:V60	4.81	Yes	No	0	6	7
19	R:R:H62	R:R:T61	4.11	No	No	0	8	8
20	R:R:D123	R:R:T61	4.34	Yes	No	0	9	8
21	R:R:Q140	R:R:Y63	7.89	No	No	0	4	5
22	R:R:I119	R:R:Y64	6.04	No	Yes	0	7	8
23	R:R:D123	R:R:Y64	8.05	Yes	Yes	0	9	8
24	R:R:G143	R:R:Y64	4.35	No	Yes	0	7	8
25	R:R:L147	R:R:N67	10.98	No	No	0	8	9
26	R:R:N67	R:R:W151	11.3	No	Yes	0	9	9
27	R:R:D72	R:R:L68	4.07	Yes	Yes	1	9	9
28	R:R:L117	R:R:L68	5.54	Yes	Yes	1	8	9
29	R:R:L68	R:R:N322	10.98	Yes	Yes	1	9	9
30	R:R:L68	R:R:Y326	3.52	Yes	Yes	1	9	9
31	R:R:D72	R:R:S113	5.89	Yes	No	0	9	9
32	R:R:D72	R:R:S319	8.83	Yes	No	0	9	9
33	R:R:D72	R:R:N322	5.39	Yes	Yes	1	9	9
34	R:R:L74	R:R:T78	4.42	No	No	0	6	6
35	R:R:C109	R:R:L74	4.76	No	No	0	6	6
36	R:R:C109	R:R:L75	6.35	No	No	0	6	8
37	R:R:L75	R:R:S319	7.51	No	No	0	8	9
38	R:R:S77	R:R:T78	6.4	No	No	0	5	6
39	R:R:V79	R:R:W102	4.9	Yes	Yes	0	8	5
40	R:R:D106	R:R:V79	8.76	No	Yes	1	7	8
41	R:R:V79	R:R:Y316	3.79	Yes	Yes	1	8	7
42	R:R:L80	R:R:S83	4.5	Yes	No	1	8	7
43	R:R:L80	R:R:Y316	7.03	Yes	Yes	1	8	7
44	R:R:F82	R:R:F94	17.15	No	No	0	5	5
45	R:R:F82	R:R:W102	9.02	No	Yes	0	5	5
46	R:R:S83	R:R:W102	3.71	No	Yes	0	7	5
47	R:R:S83	R:R:Y316	7.63	No	Yes	1	7	7
48	R:R:E87	R:R:K309	6.75	No	No	0	5	5
49	R:R:E87	R:R:W313	5.45	No	No	0	5	6
50	R:R:L89	R:R:Y91	16.41	No	No	0	5	4
51	R:R:F94	R:R:W92	15.03	No	Yes	0	5	8
52	R:R:C99	R:R:W92	24.81	No	Yes	3	9	8
53	R:R:C176	R:R:W92	7.84	No	Yes	3	9	8
54	R:R:P170	R:R:R96	5.76	Yes	No	0	4	5
55	R:R:E173	R:R:R96	5.82	No	No	0	4	5
56	R:R:F98	R:R:V97	6.55	No	No	0	5	3
57	R:R:C176	R:R:C99	7.28	No	No	3	9	9
58	R:R:L162	R:R:N100	4.12	No	No	0	5	6
59	R:R:N100	R:R:R166	10.85	No	No	0	6	5
60	R:R:A104	R:R:L162	4.73	No	No	0	6	5
61	R:R:D106	R:R:Y316	9.2	No	Yes	1	7	7
62	L:L:?1	R:R:D106	12.67	Yes	No	1	0	7
63	R:R:S158	R:R:V107	6.46	No	No	0	8	6
64	R:R:V107	R:R:Y184	3.79	No	Yes	0	6	8
65	L:L:?1	R:R:V107	12.84	Yes	No	0	0	6
66	R:R:L108	R:R:S158	4.5	No	No	0	6	8
67	R:R:C110	R:R:W285	5.22	No	Yes	1	6	8
68	L:L:?1	R:R:C110	7.98	Yes	No	1	0	6
69	R:R:M115	R:R:T111	4.52	No	No	0	6	7
70	R:R:S154	R:R:T111	6.4	No	No	0	8	7
71	R:R:S192	R:R:T111	7.99	No	No	0	6	7
72	R:R:A112	R:R:W151	7.78	No	Yes	0	8	9
73	R:R:F281	R:R:I114	3.77	Yes	No	1	9	8
74	R:R:I114	R:R:W285	10.57	No	Yes	1	8	8
75	R:R:M115	R:R:V150	4.56	No	No	0	6	6
76	R:R:L153	R:R:M115	5.65	No	No	0	5	6
77	R:R:G116	R:R:I119	3.53	No	No	0	7	7
78	R:R:F281	R:R:L117	4.87	Yes	Yes	1	9	8
79	R:R:L117	R:R:N322	8.24	Yes	Yes	1	8	9
80	R:R:L117	R:R:Y326	8.21	Yes	Yes	1	8	9
81	R:R:C118	R:R:I199	4.91	No	No	0	6	6
82	R:R:I119	R:R:V150	4.61	No	No	0	7	6
83	R:R:I120	R:R:R124	3.76	No	No	0	9	9
84	R:R:I120	R:R:Y326	6.04	No	Yes	0	9	9
85	R:R:I200	R:R:S121	4.64	No	No	0	8	9
86	R:R:M203	R:R:S121	4.6	No	No	0	6	9
87	R:R:S121	R:R:Y204	6.36	No	Yes	0	9	9
88	R:R:D123	R:R:Y134	11.49	Yes	Yes	2	9	7
89	R:R:D123	R:R:V138	4.38	Yes	Yes	2	9	6
90	R:R:R124	R:R:Y204	8.23	No	Yes	0	9	9
91	R:R:S129	R:R:Y125	11.45	No	No	0	7	8
92	R:R:M203	R:R:Y125	9.58	No	No	0	6	8
93	R:R:R206	R:R:Y125	11.32	No	No	0	6	8
94	R:R:I126	R:R:I137	4.42	No	No	0	5	5
95	R:R:I126	R:R:V138	4.61	No	Yes	0	5	6
96	R:R:G127	R:R:Y134	5.79	No	Yes	0	8	7
97	R:R:V128	R:R:V210	4.81	No	No	0	8	6
98	R:R:S129	R:R:Y130	8.9	No	No	0	7	6
99	R:R:L132	R:R:R133	6.07	No	No	0	7	5
100	R:R:P135	R:R:Y134	4.17	No	Yes	0	6	7
101	R:R:V138	R:R:Y134	12.62	Yes	Yes	2	6	7
102	R:R:G160	R:R:P161	4.06	No	No	0	7	7
103	R:R:N179	R:R:P161	9.77	Yes	No	4	5	7
104	R:R:P161	R:R:Y184	15.3	No	Yes	4	7	8
105	R:R:E181	R:R:W165	6.54	No	No	0	6	6
106	R:R:N179	R:R:R166	4.82	Yes	No	0	5	5
107	R:R:I175	R:R:P170	6.77	No	Yes	0	5	4
108	R:R:E180	R:R:I178	9.56	No	No	0	5	6
109	R:R:E181	R:R:N179	5.26	No	Yes	0	6	5
110	R:R:N179	R:R:Y184	11.63	Yes	Yes	4	5	8
111	R:R:S188	R:R:Y184	8.9	No	Yes	0	7	8
112	R:R:S296	R:R:V185	4.85	No	No	0	5	6
113	L:L:?1	R:R:S188	12.94	Yes	No	0	0	7
114	R:R:L190	R:R:Y194	3.52	No	No	0	4	6
115	R:R:F289	R:R:S192	5.28	Yes	No	1	7	6
116	L:L:?1	R:R:S192	4.31	Yes	No	1	0	6
117	R:R:F193	R:R:Y194	6.19	Yes	No	0	8	6
118	R:R:F193	R:R:L197	6.09	Yes	No	1	8	6
119	R:R:F193	R:R:F281	6.43	Yes	Yes	1	8	9
120	R:R:F193	R:R:W285	5.01	Yes	Yes	1	8	8
121	R:R:F193	R:R:L286	4.87	Yes	No	0	8	7
122	R:R:F193	R:R:F289	20.36	Yes	Yes	1	8	7
123	R:R:L195	R:R:P196	4.93	No	No	0	5	9
124	R:R:L197	R:R:L201	5.54	No	No	0	6	5
125	R:R:F281	R:R:L197	3.65	Yes	No	1	9	6
126	R:R:F281	R:R:I200	3.77	Yes	No	0	9	8
127	R:R:R206	R:R:V202	5.23	No	No	0	6	4
128	R:R:L274	R:R:Y204	3.52	No	Yes	0	9	9
129	R:R:V277	R:R:Y204	6.31	No	Yes	1	8	9
130	R:R:V278	R:R:Y204	5.05	No	Yes	0	8	9
131	R:R:Y204	R:R:Y326	3.97	Yes	Yes	1	9	9
132	R:R:K212	R:R:Y208	7.17	No	No	0	5	5
133	R:R:A271	R:R:Y208	4	No	No	0	7	5
134	R:R:L274	R:R:Y208	3.52	No	No	0	9	5
135	R:R:R213	R:R:V210	5.23	No	No	0	5	6
136	R:R:K268	R:R:K272	7.18	No	No	0	5	7
137	R:R:V277	R:R:Y326	3.79	No	Yes	1	8	9
138	R:R:F281	R:R:W285	7.02	Yes	Yes	1	9	8
139	R:R:L286	R:R:V282	4.47	No	No	0	7	5
140	R:R:C284	R:R:N318	7.87	No	No	0	8	9
141	R:R:F289	R:R:W285	6.01	Yes	Yes	1	7	8
142	R:R:G315	R:R:W285	8.44	No	Yes	0	7	8
143	R:R:N318	R:R:W285	10.17	No	Yes	0	9	8
144	L:L:?1	R:R:W285	4.91	Yes	Yes	1	0	8
145	R:R:L286	R:R:L290	6.92	No	No	0	7	6
146	R:R:P287	R:R:V311	3.53	No	No	0	9	5
147	R:R:F288	R:R:M292	3.73	Yes	Yes	0	7	7
148	R:R:F288	R:R:V311	5.24	Yes	No	0	7	5
149	R:R:F288	R:R:F312	7.5	Yes	No	1	7	6
150	L:L:?1	R:R:F288	18.37	Yes	Yes	1	0	7
151	L:L:?1	R:R:F289	7.87	Yes	Yes	1	0	7
152	R:R:V291	R:R:V311	4.81	No	No	0	5	5
153	R:R:F308	R:R:M292	3.73	No	Yes	0	4	7
154	R:R:G295	R:R:I294	3.53	No	No	0	4	5
155	R:R:G295	R:R:K302	5.23	No	No	0	4	3
156	R:R:F297	R:R:S296	7.93	No	No	0	5	5
157	R:R:D300	R:R:F298	5.97	No	No	0	1	4
158	R:R:F298	R:R:F301	18.22	No	No	0	4	3
159	R:R:K302	R:R:P303	11.71	No	No	0	3	4
160	R:R:E305	R:R:S304	4.31	No	No	0	2	5
161	R:R:S304	R:R:T306	6.4	No	No	0	5	1
162	R:R:F312	R:R:Y316	7.22	No	Yes	1	6	7
163	L:L:?1	R:R:F312	15.75	Yes	No	1	0	6
164	R:R:W313	R:R:Y316	11.58	No	Yes	0	6	7
165	L:L:?1	R:R:Y316	8.42	Yes	Yes	1	0	7
166	R:R:N318	R:R:N322	6.81	No	Yes	0	9	9
167	R:R:L108	R:R:W151	3.42	No	Yes	0	6	9
168	R:R:A112	R:R:S154	3.42	No	No	0	8	8
169	R:R:A69	R:R:V47	3.39	No	No	0	9	9
170	R:R:I114	R:R:P196	3.39	No	No	0	8	9
171	R:R:M292	R:R:P293	3.35	Yes	No	0	7	6
172	R:R:L314	R:R:P287	3.28	No	No	0	7	9
173	R:R:C118	R:R:I122	3.27	No	No	0	6	6
174	R:R:C118	R:R:I200	3.27	No	No	0	6	8
175	R:R:C280	R:R:I325	3.27	No	Yes	0	7	8
176	R:R:A69	R:R:I48	3.25	No	No	0	9	7
177	R:R:V105	R:R:V79	3.21	No	Yes	0	5	8
178	R:R:C149	R:R:L153	3.17	No	No	0	2	5
179	R:R:E181	R:R:P182	3.14	No	No	0	6	4
180	R:R:A69	R:R:N44	3.13	No	Yes	0	9	9
181	R:R:I157	R:R:S188	3.1	No	No	0	6	7
182	R:R:I45	R:R:V41	3.07	No	No	0	4	6
183	R:R:I48	R:R:V70	3.07	No	No	0	7	6
184	R:R:K309	R:R:T306	3	No	No	0	5	1
185	R:R:L274	R:R:V207	2.98	No	No	0	9	9
186	R:R:L80	R:R:T76	2.95	Yes	No	0	8	7
187	R:R:I324	R:R:I325	2.94	No	Yes	0	6	8
188	R:R:F297	R:R:P182	2.89	No	No	0	5	4
189	R:R:F298	R:R:P299	2.89	No	No	0	4	2
190	R:R:I45	R:R:L49	2.85	No	No	0	4	4
191	R:R:I45	R:R:L73	2.85	No	No	0	4	7
192	R:R:I85	R:R:L89	2.85	No	No	0	5	5
193	R:R:I321	R:R:L317	2.85	No	No	0	6	5
194	R:R:G95	R:R:W92	2.81	No	Yes	0	8	8
195	R:R:C176	R:R:R96	2.79	No	No	0	9	5
196	R:R:A189	R:R:F289	2.77	No	Yes	0	7	7
197	R:R:L73	R:R:N44	2.75	No	Yes	0	7	9
198	R:R:E180	R:R:M292	2.71	No	Yes	0	5	7
199	R:R:L144	R:R:Q140	2.66	No	No	0	5	4
200	R:R:N179	R:R:Q167	2.64	Yes	No	0	5	5
201	R:R:A71	R:R:W151	2.59	No	Yes	0	8	9
202	R:R:F187	R:R:I157	2.51	No	No	0	5	6
203	R:R:T174	R:R:Y91	2.5	No	No	0	1	4
204	R:R:F308	R:R:K302	2.48	No	No	0	4	3
205	R:R:F297	R:R:L186	2.44	No	No	0	5	6
206	R:R:I325	R:R:Y326	2.42	Yes	Yes	0	8	9
207	R:R:E87	R:R:F86	2.33	No	No	0	5	4
208	R:R:G34	R:R:G35	2.11	No	No	0	3	5
209	R:R:G183	R:R:P182	2.03	No	No	0	5	4
210	R:R:A169	R:R:P170	1.87	No	Yes	0	3	4
211	R:R:G279	R:R:V278	1.84	No	No	0	5	8
212	R:R:G40	R:R:T76	1.82	No	No	0	8	7
213	R:R:A211	R:R:A270	1.79	No	No	0	8	8
214	R:R:P303	R:R:V307	1.77	No	No	0	4	5
215	R:R:G191	R:R:I157	1.76	No	No	0	5	6
216	R:R:G34	R:R:L33	1.71	No	No	0	3	7
217	R:R:G35	R:R:L38	1.71	No	No	0	5	4
218	R:R:G43	R:R:L42	1.71	No	No	0	9	4
219	R:R:G90	R:R:L89	1.71	No	No	0	4	5
220	R:R:I65	R:R:P327	1.69	No	No	0	7	7
221	R:R:C280	R:R:I276	1.64	No	No	0	7	7
222	R:R:A84	R:R:I37	1.62	No	Yes	0	6	5
223	R:R:V128	R:R:V207	1.6	No	No	0	8	9
224	R:R:C320	R:R:L36	1.59	No	No	0	6	7
225	R:R:T273	R:R:V277	1.59	No	No	0	9	8
226	R:R:P168	R:R:Q167	1.58	No	No	0	4	5
227	R:R:E171	R:R:P170	1.57	No	Yes	0	3	4
228	R:R:A103	R:R:N100	1.56	No	No	0	6	6
229	R:R:I175	R:R:T174	1.52	No	No	0	5	1
230	R:R:L155	R:R:V156	1.49	No	No	0	4	4
231	R:R:I321	R:R:I325	1.47	No	Yes	0	6	8
232	R:R:D172	R:R:T174	1.45	No	No	0	3	1
233	R:R:Q140	R:R:V60	1.43	No	No	0	4	7
234	R:R:I159	R:R:L155	1.43	No	No	0	4	4
235	R:R:P131	R:R:Y130	1.39	No	No	0	8	6
236	R:R:L108	R:R:L155	1.38	No	No	0	6	4
237	R:R:L147	R:R:L148	1.38	No	No	0	8	4
238	R:R:A146	R:R:Y64	1.33	No	Yes	0	6	8
239	R:R:R133	R:R:T136	1.29	No	No	0	5	4
240	R:R:R142	R:R:T139	1.29	No	No	0	6	7
241	R:R:Q167	R:R:Q177	1.28	No	No	0	5	5
242	R:R:F163	R:R:I159	1.26	No	No	0	4	4
243	R:R:F301	R:R:I294	1.26	No	No	0	3	5
244	R:R:I101	R:R:W102	1.17	No	Yes	0	5	5
245	R:R:E214	R:R:R213	1.16	No	No	0	7	5
246	R:R:F94	R:R:F98	1.07	No	No	0	5	5
247	R:R:R133	R:R:Y130	1.03	No	No	0	5	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:I37	5.4775	4	0	5
2	R:R:N44	5.19	4	0	9
3	R:R:Y64	5.468	5	0	8
4	R:R:L68	6.0275	4	1	9
5	R:R:D72	6.182	5	1	9
6	R:R:V79	5.165	4	1	8
7	R:R:L80	6.1175	4	1	8
8	R:R:W92	12.6225	4	3	8
9	R:R:W102	4.7	4	0	5
10	R:R:L117	6.715	4	1	8
11	R:R:D123	7.065	4	2	9
12	R:R:Y134	8.5175	4	2	7
13	R:R:V138	6.605	4	2	6
14	R:R:W151	6.2725	4	0	9
15	R:R:P170	3.9925	4	0	4
16	R:R:N179	6.824	5	4	5
17	R:R:Y184	9.905	4	4	8
18	R:R:F193	8.15833	6	1	8
19	R:R:Y204	5.57333	6	1	9
20	R:R:F281	4.91833	6	1	9
21	R:R:W285	7.16875	8	1	8
22	R:R:F288	8.71	4	1	7
23	R:R:F289	8.458	5	1	7
24	R:R:M292	3.38	4	0	7
25	R:R:Y316	7.83857	7	1	7
26	R:R:N322	7.855	4	1	9
27	R:R:I325	2.525	4	0	8
28	R:R:Y326	4.65833	6	1	9
29	L:L:?1	10.606	10	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I37	R:R:L80	10.2611	9.99	Yes	Yes	0	5	8
2	R:R:I325	R:R:Y326	12.9253	2.42	Yes	Yes	0	8	9
3	R:R:L117	R:R:Y326	37.225	8.21	Yes	Yes	1	8	9
4	R:R:F281	R:R:L117	43.6982	4.87	Yes	Yes	1	9	8
5	R:R:F281	R:R:W285	71.0578	7.02	Yes	Yes	1	9	8
6	L:L:?1	R:R:W285	100	4.91	Yes	Yes	1	0	8
7	L:L:?1	R:R:Y316	76.2279	8.42	Yes	Yes	1	0	7
8	R:R:L80	R:R:Y316	15.8217	7.03	Yes	Yes	1	8	7
9	R:R:N318	R:R:W285	34.8615	10.17	No	Yes	0	9	8
10	R:R:N318	R:R:N322	32.7724	6.81	No	Yes	0	9	9
11	R:R:D72	R:R:N322	31.6803	5.39	Yes	Yes	1	9	9
12	R:R:D72	R:R:N44	24.7375	6.73	Yes	Yes	0	9	9
13	R:R:A69	R:R:N44	10.852	3.13	No	Yes	0	9	9
14	L:L:?1	R:R:S192	43.9937	4.31	Yes	No	1	0	6
15	R:R:S192	R:R:T111	69.607	7.99	No	No	0	6	7
16	R:R:M115	R:R:T111	65.3231	4.52	No	No	0	6	7
17	R:R:M115	R:R:V150	59.2139	4.56	No	No	0	6	6
18	R:R:I119	R:R:V150	57.1564	4.61	No	No	0	7	6
19	R:R:I119	R:R:Y64	52.9728	6.04	No	Yes	0	7	8
20	R:R:D123	R:R:Y64	32.6299	8.05	Yes	Yes	0	9	8
21	R:R:D123	R:R:T61	18.4595	4.34	Yes	No	0	9	8
22	R:R:H62	R:R:T61	16.2068	4.11	No	No	0	8	8
23	R:R:H62	R:R:L57	11.6275	28.28	No	No	0	8	8
24	R:R:V60	R:R:Y64	15.0725	7.57	No	Yes	0	7	8
25	L:L:?1	R:R:V107	40.248	12.84	Yes	No	0	0	6
26	R:R:S158	R:R:V107	14.6399	6.46	No	No	0	8	6
27	R:R:L108	R:R:S158	13.2102	4.5	No	No	0	6	8
28	R:R:D72	R:R:S319	10.852	8.83	Yes	No	0	9	9
29	R:R:V79	R:R:Y316	30.9628	3.79	Yes	Yes	1	8	7
30	R:R:S83	R:R:W102	29.9446	3.71	No	Yes	0	7	5
31	R:R:F82	R:R:W102	77.1089	9.02	No	Yes	0	5	5
32	R:R:F82	R:R:F94	73.3632	17.15	No	No	0	5	5
33	R:R:W313	R:R:Y316	10.6041	11.58	No	Yes	0	6	7
34	R:R:F94	R:R:W92	62.0364	15.03	No	Yes	0	5	8
35	R:R:C176	R:R:W92	50.5408	7.84	No	Yes	3	9	8
36	R:R:C176	R:R:R96	46.7792	2.79	No	No	0	9	5
37	R:R:P170	R:R:R96	39.0873	5.76	Yes	No	0	4	5
38	R:R:I175	R:R:P170	27.4703	6.77	No	Yes	0	5	4
39	R:R:I175	R:R:T174	23.5769	1.52	No	No	0	5	1
40	R:R:T174	R:R:Y91	15.7584	2.5	No	No	0	1	4
41	R:R:L89	R:R:Y91	11.8333	16.41	No	No	0	5	4
42	R:R:V107	R:R:Y184	27.3173	3.79	No	Yes	0	6	8
43	R:R:N179	R:R:Y184	45.6819	11.63	Yes	Yes	4	5	8
44	R:R:N179	R:R:R166	13.3105	4.82	Yes	No	0	5	5
45	R:R:N100	R:R:R166	10.4616	10.85	No	No	0	6	5
46	L:L:?1	R:R:S188	31.559	12.94	Yes	No	0	0	7
47	R:R:S188	R:R:Y184	26.5787	8.9	No	Yes	0	7	8
48	R:R:F281	R:R:I200	43.3448	3.77	Yes	No	0	9	8
49	R:R:Y204	R:R:Y326	23.8248	3.97	Yes	Yes	1	9	9
50	R:R:I200	R:R:S121	37.0984	4.64	No	No	0	8	9
51	R:R:S121	R:R:Y204	22.6959	6.36	No	Yes	0	9	9
52	R:R:M203	R:R:S121	18.3434	4.6	No	No	0	6	9
53	R:R:M203	R:R:Y125	16.5233	9.58	No	No	0	6	8
54	R:R:S129	R:R:Y125	11.2952	11.45	No	No	0	7	8
55	R:R:L274	R:R:Y204	29.5911	3.52	No	Yes	0	9	9
56	R:R:L274	R:R:V207	16.6025	2.98	No	No	0	9	9
57	R:R:V128	R:R:V207	13.1944	1.6	No	No	0	8	9
58	R:R:V128	R:R:V210	10.3245	4.81	No	No	0	8	6
59	R:R:E181	R:R:N179	22.7433	5.26	No	Yes	0	6	5
60	R:R:F288	R:R:M292	26.0195	3.73	Yes	Yes	0	7	7
61	L:L:?1	R:R:F288	28.4569	18.37	Yes	Yes	1	0	7
62	R:R:E181	R:R:P182	17.1195	3.14	No	No	0	6	4
63	R:R:F297	R:R:P182	11.4534	2.89	No	No	0	5	4
64	R:R:F193	R:R:F289	19.3458	20.36	Yes	Yes	1	8	7
65	R:R:L274	R:R:Y208	10.3139	3.52	No	No	0	9	5
66	R:R:F308	R:R:M292	18.9238	3.73	No	Yes	0	4	7
67	R:R:G295	R:R:K302	11.8016	5.23	No	No	0	4	3
68	R:R:F308	R:R:K302	17.2936	2.48	No	No	0	4	3
69	R:R:F193	R:R:F281	13.7325	6.43	Yes	Yes	1	8	9
70	R:R:F289	R:R:S192	27.5389	5.28	Yes	No	1	7	6
71	R:R:F289	R:R:W285	16.5022	6.01	Yes	Yes	1	7	8
72	L:L:?1	R:R:D106	28.6943	12.67	Yes	No	1	0	7
73	R:R:D106	R:R:V79	27.6602	8.76	No	Yes	1	7	8
74	R:R:V79	R:R:W102	54.0069	4.9	Yes	Yes	0	8	5
75	R:R:S83	R:R:Y316	29.5067	7.63	No	Yes	1	7	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D106	R:R:V79	8.76	1	No	Yes	7	8	1	2
R:R:V79	R:R:Y316	3.79	1	Yes	Yes	8	7	2	1
R:R:L80	R:R:S83	4.5	1	Yes	No	8	7	2	2
R:R:L80	R:R:Y316	7.03	1	Yes	Yes	8	7	2	1
R:R:S83	R:R:Y316	7.63	1	No	Yes	7	7	2	1
R:R:D106	R:R:Y316	9.2	1	No	Yes	7	7	1	1
L:L:?1	R:R:D106	12.67	1	Yes	No	0	7	0	1
R:R:S158	R:R:V107	6.46	0	No	No	8	6	2	1
R:R:V107	R:R:Y184	3.79	0	No	Yes	6	8	1	2
L:L:?1	R:R:V107	12.84	1	Yes	No	0	6	0	1
R:R:C110	R:R:W285	5.22	1	No	Yes	6	8	1	1
L:L:?1	R:R:C110	7.98	1	Yes	No	0	6	0	1
R:R:S192	R:R:T111	7.99	1	No	No	6	7	1	2
R:R:F281	R:R:I114	3.77	1	Yes	No	9	8	2	2
R:R:I114	R:R:W285	10.57	1	No	Yes	8	8	2	1
R:R:S188	R:R:Y184	8.9	0	No	Yes	7	8	1	2
L:L:?1	R:R:S188	12.94	1	Yes	No	0	7	0	1
R:R:F289	R:R:S192	5.28	1	Yes	No	7	6	1	1
L:L:?1	R:R:S192	4.31	1	Yes	No	0	6	0	1
R:R:F193	R:R:F281	6.43	1	Yes	Yes	8	9	2	2
R:R:F193	R:R:W285	5.01	1	Yes	Yes	8	8	2	1
R:R:F193	R:R:F289	20.36	1	Yes	Yes	8	7	2	1
R:R:F281	R:R:W285	7.02	1	Yes	Yes	9	8	2	1
R:R:F289	R:R:W285	6.01	1	Yes	Yes	7	8	1	1
R:R:G315	R:R:W285	8.44	0	No	Yes	7	8	2	1
R:R:N318	R:R:W285	10.17	0	No	Yes	9	8	2	1
L:L:?1	R:R:W285	4.91	1	Yes	Yes	0	8	0	1
R:R:F288	R:R:M292	3.73	1	Yes	Yes	7	7	1	2
R:R:F288	R:R:V311	5.24	1	Yes	No	7	5	1	2
R:R:F288	R:R:F312	7.5	1	Yes	No	7	6	1	1
L:L:?1	R:R:F288	18.37	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:F289	7.87	1	Yes	Yes	0	7	0	1
R:R:F312	R:R:Y316	7.22	1	No	Yes	6	7	1	1
L:L:?1	R:R:F312	15.75	1	Yes	No	0	6	0	1
R:R:W313	R:R:Y316	11.58	0	No	Yes	6	7	2	1
L:L:?1	R:R:Y316	8.42	1	Yes	Yes	0	7	0	1
R:R:I157	R:R:S188	3.1	0	No	No	6	7	2	1
R:R:A189	R:R:F289	2.77	0	No	Yes	7	7	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8THK_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.52
Number of Linked Nodes	226
Number of Links	247
Number of Hubs	29
Number of Links mediated by Hubs	111
Number of Communities	4
Number of Nodes involved in Communities	32
Number of Links involved in Communities	47

Path Summary
Number Of Nodes in MetaPath	76
Number Of Links MetaPath	75
Number of Shortest Paths	47952
Length Of Smallest Path	3
Average Path Length	12.524
Length of Longest Path	27
Minimum Path Strength	1.16
Average Path Strength	6.80823
Maximum Path Strength	23.78
Minimum Path Correlation	0.7
Average Path Correlation	0.913405
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5.55556
Average % Of Corr. Nodes	45.5226
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	43.8497
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• hydrolase activity, acting on glycosyl bonds • peptidoglycan muralytic activity • hydrolase activity, hydrolyzing O-glycosyl compounds • lysozyme activity • hydrolase activity • catalytic activity • protein heterodimerization activity • protein binding • binding • protein dimerization activity • alpha1-adrenergic receptor activity • alpha-adrenergic receptor activity • G protein-coupled amine receptor activity • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • adrenergic receptor activity • defense response to bacterium • biological process involved in interspecies interaction between organisms • response to stimulus • response to other organism • defense response • response to bacterium • response to stress • response to external stimulus • response to external biotic stimulus • response to biotic stimulus • carbohydrate derivative catabolic process • catabolic process • peptidoglycan catabolic process • glycosaminoglycan metabolic process
Gene Ontology	Biological Process	• defense response to bacterium • biological process involved in interspecies interaction between organisms • response to stimulus • response to other organism • defense response • response to bacterium • response to stress • response to external stimulus • response to external biotic stimulus • response to biotic stimulus • carbohydrate derivative catabolic process • catabolic process • peptidoglycan catabolic process • glycosaminoglycan metabolic process • carbohydrate derivative metabolic process • aminoglycan catabolic process • macromolecule catabolic process • glycosaminoglycan catabolic process • aminoglycan metabolic process • peptidoglycan metabolic process • metabolic process • cellular process • macromolecule metabolic process • symbiont-mediated cytolysis of host cell • viral life cycle • disruption of cell in another organism • cytolysis • biological process involved in interaction with host • biological process involved in symbiotic interaction • viral release from host cell by cytolysis • exit from host cell • viral process • cytolysis in another organism • viral release from host cell • disruption of anatomical structure in another organism • symbiont-mediated killing of host cell • killing of cells of another organism • cell killing • cell wall organization or biogenesis • cell wall macromolecule catabolic process • cell wall macromolecule metabolic process • response to chemical • response to xenobiotic stimulus • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • regulation of biological process • signaling • cell-cell signaling • neuron-glial cell signaling • cell communication • cellular response to stimulus • positive regulation of cell communication • regulation of cellular process • positive regulation of signal transduction • positive regulation of biological process • regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • intracellular signaling cassette • signal transduction • positive regulation of cellular process • regulation of signaling • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • regulation of tube diameter • multicellular organismal process • system process • regulation of tube size • regulation of system process • positive regulation of vasoconstriction • circulatory system process • regulation of blood circulation • vascular process in circulatory system • regulation of vasoconstriction • positive regulation of multicellular organismal process • regulation of multicellular organismal process • blood vessel diameter maintenance • vasoconstriction • blood circulation • regulation of anatomical structure size • heart process • negative regulation of heart rate • regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback • regulation of heart contraction • negative regulation of biological process • negative regulation of blood pressure • negative regulation of systemic arterial blood pressure • nervous system process involved in regulation of systemic arterial blood pressure • regulation of heart rate • nervous system process • regulation of blood pressure • regulation of systemic arterial blood pressure by baroreceptor feedback • negative regulation of blood circulation • negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure • baroreceptor response to increased systemic arterial blood pressure • negative regulation of heart contraction • regulation of systemic arterial blood pressure • heart contraction • negative regulation of multicellular organismal process • phospholipase C-activating G protein-coupled receptor signaling pathway • phospholipase C-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • G protein-coupled receptor signaling pathway • regulation of systemic arterial blood pressure mediated by a chemical signal • positive regulation of blood pressure • positive regulation of blood circulation • regulation of systemic arterial blood pressure by norepinephrine-epinephrine • positive regulation of blood pressure by epinephrine-norepinephrine • positive regulation of heart rate • positive regulation of heart rate by epinephrine-norepinephrine • positive regulation of heart contraction • reflex • pilomotor reflex • modulation of chemical synaptic transmission • positive regulation of synaptic transmission, GABAergic • synaptic signaling • trans-synaptic signaling • synaptic transmission, GABAergic • positive regulation of synaptic transmission • chemical synaptic transmission • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • regulation of synaptic transmission, GABAergic • smooth muscle contraction • muscle contraction • muscle system process • apoptotic process • cell death • programmed cell death • norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure • regulation of action potential • positive regulation of action potential • action potential • regulation of membrane potential • adenylate cyclase-activating adrenergic receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • negative regulation of cell population proliferation • cell population proliferation • regulation of cell population proliferation • negative regulation of cellular process • muscle hypertrophy • regulation of muscle adaptation • positive regulation of cardiac muscle hypertrophy • striated muscle hypertrophy • regulation of muscle system process • regulation of cardiac muscle hypertrophy • regulation of muscle hypertrophy • muscle adaptation • positive regulation of muscle hypertrophy • cardiac muscle hypertrophy • negative regulation of catabolic process • negative regulation of metabolic process • autophagy • regulation of catabolic process • regulation of autophagy • negative regulation of autophagy • process utilizing autophagic mechanism • regulation of metabolic process • positive regulation of smooth muscle contraction • regulation of muscle contraction • regulation of smooth muscle contraction • positive regulation of muscle contraction • cellular developmental process • cardiac muscle cell development • developmental growth • cell development • organ growth • muscle cell differentiation • cell growth • striated muscle tissue development • muscle structure development • multicellular organism development • striated muscle cell development • muscle cell development • cell differentiation • anatomical structure development • cardiac cell development • muscle tissue development • cardiac muscle tissue growth • system development • developmental process • heart development • heart growth • developmental cell growth • cardiac muscle tissue development • physiological muscle hypertrophy • growth • animal organ development • cardiac muscle cell differentiation • tissue development • cardiocyte differentiation • circulatory system development • cell growth involved in cardiac muscle cell development • physiological cardiac muscle hypertrophy • striated muscle cell differentiation • regulation of the force of heart contraction by chemical signal • regulation of the force of heart contraction • positive regulation of the force of heart contraction by chemical signal • positive regulation of the force of heart contraction by epinephrine-norepinephrine • adult heart development • response to hormone • response to endogenous stimulus • positive regulation of cardiac muscle contraction • cardiac muscle contraction • striated muscle contraction • positive regulation of striated muscle contraction • regulation of cardiac muscle contraction • regulation of striated muscle contraction • host cellular component • host intracellular part • cellular anatomical structure • host cell cytoplasm • host cell part • host intracellular region • other organism part • membrane-bounded organelle • intracellular anatomical structure • nuclear membrane • membrane • nucleus • intracellular membrane-bounded organelle • endomembrane system
Gene Ontology	Cellular Component	• host cellular component • host intracellular part • cellular anatomical structure • host cell cytoplasm • host cell part • host intracellular region • other organism part • membrane-bounded organelle • intracellular anatomical structure • nuclear membrane • membrane • nucleus • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • organelle envelope • organelle • nuclear envelope • organelle membrane • cytoplasm • cytosol • membrane microdomain • cell periphery • membrane raft • plasma membrane raft • plasma membrane • plasma membrane region • caveola • membrane-enclosed lumen • intracellular organelle lumen • nucleoplasm • organelle lumen • nuclear lumen • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • synapse • cell junction • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • G-protein beta/gamma-subunit complex binding • signaling receptor binding • G protein-coupled receptor binding • cation binding • metal ion binding • GTPase regulator activity • enzyme regulator activity • enzyme activator activity • GTPase activator activity • molecular function activator activity • nucleoside-triphosphatase regulator activity • molecular function regulator activity • G protein activity • D1 dopamine receptor binding • dopamine receptor binding • cyclase regulator activity • cyclase activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • positive regulation of cell population proliferation • positive regulation of biological process • positive regulation of neural precursor cell proliferation • regulation of cell population proliferation • neural precursor cell proliferation • positive regulation of cellular process • regulation of neural precursor cell proliferation • reactive oxygen species metabolic process • regulation of superoxide metabolic process • positive regulation of reactive oxygen species metabolic process • superoxide metabolic process • positive regulation of metabolic process • superoxide anion generation • metabolic process • positive regulation of superoxide anion generation • regulation of superoxide anion generation • regulation of metabolic process • regulation of reactive oxygen species metabolic process • regulation of calcium ion transport • regulation of localization • transport • regulation of transport • regulation of monoatomic ion transport • establishment of localization • metal ion transport • calcium ion transport • localization • monoatomic ion transport • regulation of metal ion transport • monoatomic cation transport • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • regulation of signaling • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • negative regulation of signaling • negative regulation of biological process • negative regulation of G protein-coupled receptor signaling pathway • negative regulation of cell communication • negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • negative regulation of cellular process • regulation of G protein-coupled receptor signaling pathway • adenylate cyclase-activating adrenergic receptor signaling pathway • negative regulation of response to stimulus • negative regulation of signal transduction • negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway • regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell division • regulation of body fluid levels • renal system process • positive regulation of urine volume • regulation of urine volume • regulation of biological quality • regulation of vascular associated smooth muscle cell proliferation • positive regulation of vascular associated smooth muscle cell proliferation • regulation of smooth muscle cell proliferation • smooth muscle cell proliferation • positive regulation of smooth muscle cell proliferation • muscle cell proliferation • vascular associated smooth muscle cell proliferation • gamma-aminobutyric acid signaling pathway • purinergic nucleotide receptor signaling pathway • cell surface receptor signaling pathway • G protein-coupled purinergic receptor signaling pathway • G protein-coupled adenosine receptor signaling pathway • regulation of molecular function • regulation of adenylate cyclase activity • regulation of catalytic activity • negative regulation of molecular function • negative regulation of catalytic activity • negative regulation of adenylate cyclase activity • regulated exocytosis • regulation of calcium ion-dependent exocytosis • negative regulation of transport • negative regulation of regulated secretory pathway • vesicle-mediated transport • regulation of regulated secretory pathway • secretion by cell • regulation of secretion by cell • negative regulation of secretion • negative regulation of exocytosis • negative regulation of secretion by cell • calcium-ion regulated exocytosis • secretion • negative regulation of calcium ion-dependent exocytosis • export from cell • regulation of vesicle-mediated transport • regulation of secretion • exocytosis • regulation of exocytosis • regulation of programmed cell death • negative regulation of apoptotic signaling pathway • negative regulation of programmed cell death • regulation of apoptotic process • cell death • apoptotic signaling pathway • negative regulation of apoptotic process • apoptotic process • programmed cell death • regulation of apoptotic signaling pathway • positive regulation of locomotion • regulation of cell motility • positive regulation of cell migration • regulation of locomotion • positive regulation of cell motility • regulation of cell migration • cell migration • cell motility • locomotion • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • trans-synaptic signaling • modulation of chemical synaptic transmission • negative regulation of synaptic transmission • chemical synaptic transmission • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • response to nutrient levels • response to nutrient • regulation of Wnt signaling pathway • regulation of canonical Wnt signaling pathway • canonical Wnt signaling pathway • Wnt signaling pathway • neuropeptide signaling pathway • wound healing • hemostasis • blood coagulation • response to stress • coagulation • response to wounding • regulation of protein stability • protein stabilization • phospholipase C-activating serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • rhythmic process • entrainment of circadian clock • circadian rhythm • response to external stimulus • regulation of circadian rhythm • hormone-mediated signaling pathway • response to pH • cellular response to pH • response to abiotic stimulus • cellular response to acidic pH • response to acidic pH • cellular response to abiotic stimulus • cellular response to environmental stimulus • glutamate receptor signaling pathway • sensory perception of itch • establishment of organelle localization • cellular localization • cell activation involved in immune response • leukocyte degranulation • myeloid leukocyte activation • myeloid leukocyte mediated immunity • leukocyte activation • organelle localization • leukocyte activation involved in immune response • establishment of localization in cell • mast cell activation • leukocyte mediated immunity • mast cell mediated immunity • immune response • cell activation • vacuolar localization • mast cell degranulation • myeloid cell activation involved in immune response • immune effector process • mast cell activation involved in immune response • immune system process • lysosome localization • detection of light stimulus • response to light stimulus • phototransduction • detection of external stimulus • detection of visible light • detection of abiotic stimulus • detection of stimulus • response to radiation • phototransduction, visible light • regulation of cell activation • regulation of platelet activation • regulation of multicellular organismal process • platelet activation • phospholipase C-activating G protein-coupled glutamate receptor signaling pathway • G protein-coupled glutamate receptor signaling pathway • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • cellular homeostasis • chemical homeostasis • homeostatic process • glucose homeostasis • carbohydrate homeostasis • intracellular chemical homeostasis • intracellular glucose homeostasis • neuromuscular process • regulation of system process • skeletal muscle contraction • muscle contraction • muscle system process • regulation of muscle system process • striated muscle contraction • multicellular organismal movement • musculoskeletal movement • regulation of striated muscle contraction • regulation of muscle contraction • regulation of skeletal muscle contraction • sensory perception of smell • response to peptide hormone • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • skeletal system development • bone development • homotypic cell-cell adhesion • platelet aggregation • cell adhesion • cell-cell adhesion • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • adaptive thermogenesis • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • establishment of protein localization • nitrogen compound transport • positive regulation of establishment of protein localization • positive regulation of insulin secretion involved in cellular response to glucose stimulus • positive regulation of insulin secretion • intracellular protein localization • regulation of peptide hormone secretion • regulation of hormone levels • positive regulation of peptide hormone secretion • establishment of protein localization to extracellular region • protein secretion • regulation of protein secretion • cellular response to carbohydrate stimulus • response to glucose • positive regulation of protein localization • insulin secretion involved in cellular response to glucose stimulus • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • positive regulation of secretion by cell • hormone secretion • protein localization to extracellular region • positive regulation of protein transport • peptide secretion • positive regulation of hormone secretion • response to monosaccharide • response to carbohydrate • positive regulation of secretion • signal release • cellular response to hexose stimulus • cellular response to monosaccharide stimulus • positive regulation of peptide secretion • regulation of peptide transport • regulation of establishment of protein localization • cellular response to glucose stimulus • regulation of protein transport • positive regulation of protein secretion • peptide transport • response to hexose • positive regulation of transport • regulation of cellular localization • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • regulation of insulin secretion involved in cellular response to glucose stimulus • hormone transport • insulin secretion • serotonin receptor signaling pathway • adenylate cyclase-activating serotonin receptor signaling pathway • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • regulation of inflammatory response • negative regulation of immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • positive regulation of catalytic activity • positive regulation of lyase activity • bile acid signaling pathway • adenylate cyclase-activating G protein-coupled bile acid receptor signaling pathway • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • midbody • dense core granule • intracellular vesicle • cytoplasmic vesicle • secretory granule • secretory vesicle • neuronal dense core vesicle • centrosome • microtubule organizing center • cytoskeleton • membraneless organelle • intracellular membraneless organelle • microtubule cytoskeleton • somatodendritic compartment • dendrite • dendritic tree • neuron to neuron synapse • hippocampal mossy fiber to CA3 synapse • cell body • ciliary basal body • Golgi apparatus • postsynapse • postsynaptic cytosol • Golgi apparatus subcompartment • organelle subcompartment • trans-Golgi network membrane • trans-Golgi network
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	CGZ
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	CGZ
Name	N-[(5S)-5-(4,5-dihydro-1H-imidazol-2-yl)-2-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl]methanesulfonamide
Synonyms
Identifier
Formula	C14 H19 N3 O3 S
Molecular Weight	309.384
SMILES
PubChem	10804826
Formal Charge	0
Total Atoms	40
Total Chiral Atoms	1
Total Bonds	42
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P35348
Sequence	>8THK_nogp_Chain_R L G G L I L F G V L G N I L V I L S V A C H R H L H S V T H Y Y I V N L A V A D L L L T S T V L P F S A I F E V L G Y W A F G R V F C N I W A A V D V L C C T A S I M G L C I I S I D R Y I G V S Y P L R Y P T I V T Q R R G L M A L L C V W A L S L V I S I G P L F G W R Q P A P E D E T I C Q I N E E P G Y V L F S A L G S F Y L P L A I I L V M Y C R V Y V V A K R E S K K A A K T L G I V V G C F V L C W L P F F L V M P I G S F F P D F K P S E T V F K I V F W L G Y L N S C I N P I I Y P C Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7YM8	A	Amine	Adrenergic	Alpha1A	Homo sapiens	Oxymetazoline	-	chim(Gs-CtGq)	2.92	2023-07-05	doi.org/10.1038/s41467-023-39310-x
	7YM8 (No Gprot)	A	Amine	Adrenergic	Alpha1A	Homo sapiens	Oxymetazoline	-		2.92	2023-07-05	doi.org/10.1038/s41467-023-39310-x
	7YMH	A	Amine	Adrenergic	Alpha1A	Homo sapiens	Norepinephrine	-	chim(Gs-CtGq)	3.52	2023-07-05	doi.org/10.1038/s41467-023-39310-x
	7YMH (No Gprot)	A	Amine	Adrenergic	Alpha1A	Homo sapiens	Norepinephrine	-		3.52	2023-07-05	doi.org/10.1038/s41467-023-39310-x
	7YMJ	A	Amine	Adrenergic	Alpha1A	Homo sapiens	Tamsulosin	-	-	3.35	2023-07-05	doi.org/10.1038/s41467-023-39310-x
	8THK	A	Amine	Adrenergic	Alpha1A	Homo sapiens	A-61603	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	2.6	2023-08-16	doi.org/10.1038/s41467-023-40524-2
	8THK (No Gprot)	A	Amine	Adrenergic	Alpha1A	Homo sapiens	A-61603	-		2.6	2023-08-16	doi.org/10.1038/s41467-023-40524-2
	8THL	A	Amine	Adrenergic	Alpha1A	Homo sapiens	Epinephrine	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.1	2023-08-16	doi.org/10.1038/s41467-023-40524-2
	8THL (No Gprot)	A	Amine	Adrenergic	Alpha1A	Homo sapiens	Epinephrine	-		3.1	2023-08-16	doi.org/10.1038/s41467-023-40524-2
	8HN1	A	Amine	Adrenergic	Alpha1A	Homo sapiens	Toxin AdTx1	-	-	2.9	2023-12-20	To be published
	9M4Q	A	Amine	Adrenergic	Alpha1A	Homo sapiens	Doxazosin	-	-	2.99	2025-07-02	doi.org/10.1016/j.jbc.2025.110348
	9M4T	A	Amine	Adrenergic	Alpha1A	Homo sapiens	Silodosin	-	-	3.19	2025-07-02	doi.org/10.1016/j.jbc.2025.110348
	9IQV	A	Amine	Adrenergic	Alpha1A	Homo sapiens	-	Muscarinic toxin 3	-	3.3	2025-07-23	To be published

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