psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D106	12.59	Yes	No	1	0	7
2	L:L:?1	R:R:V107	12.44	Yes	No	0	0	6
3	L:L:?1	R:R:C110	5.89	Yes	No	0	0	6
4	L:L:?1	R:R:I178	5.3	Yes	No	1	0	6
5	L:L:?1	R:R:F288	21.47	Yes	No	1	0	7
6	L:L:?1	R:R:F289	5.65	Yes	Yes	1	0	7
7	L:L:?1	R:R:F312	11.3	Yes	No	1	0	6
8	L:L:?1	R:R:Y316	4.35	Yes	Yes	1	0	7
9	R:R:K25	R:R:L28	4.23	No	No	0	3	4
10	R:R:I37	R:R:L33	4.28	Yes	Yes	0	5	7
11	R:R:A84	R:R:L33	6.3	No	Yes	0	6	7
12	R:R:L33	R:R:W313	11.39	Yes	Yes	0	7	6
13	R:R:C320	R:R:L36	6.35	No	No	0	6	7
14	R:R:I37	R:R:L80	7.14	Yes	Yes	0	5	8
15	R:R:C320	R:R:G40	3.92	No	No	0	6	8
16	R:R:G43	R:R:P323	4.06	No	No	0	9	9
17	R:R:D72	R:R:N44	6.73	Yes	No	0	9	9
18	R:R:N44	R:R:P323	9.77	No	No	0	9	9
19	R:R:F337	R:R:L46	12.18	No	No	0	7	7
20	R:R:A69	R:R:V47	3.39	No	No	0	9	9
21	R:R:P327	R:R:V47	3.53	No	No	0	7	9
22	R:R:I48	R:R:V70	3.07	No	No	0	7	6
23	R:R:V51	R:R:V66	4.81	No	No	0	8	6
24	R:R:F333	R:R:V51	3.93	Yes	No	0	8	8
25	R:R:C53	R:R:H54	7.37	No	No	0	5	6
26	R:R:H54	R:R:L57	3.86	No	Yes	0	6	8
27	R:R:H62	R:R:L57	9	No	Yes	4	8	8
28	R:R:E332	R:R:L57	3.98	No	Yes	0	7	8
29	R:R:F333	R:R:L57	4.87	Yes	Yes	4	8	8
30	R:R:H58	R:R:Y63	14.16	No	No	0	8	5
31	R:R:S59	R:R:T61	3.2	No	No	0	7	8
32	R:R:H62	R:R:S59	13.95	No	No	0	8	7
33	R:R:V60	R:R:Y64	5.05	Yes	Yes	0	7	8
34	R:R:V138	R:R:V60	4.81	Yes	Yes	0	6	7
35	R:R:D123	R:R:T61	10.12	No	No	0	9	8
36	R:R:F333	R:R:H62	9.05	Yes	No	4	8	8
37	R:R:I119	R:R:Y64	6.04	No	Yes	0	7	8
38	R:R:D123	R:R:Y64	6.9	No	Yes	0	9	8
39	R:R:F333	R:R:I65	8.79	Yes	No	0	8	7
40	R:R:L147	R:R:N67	8.24	No	No	0	8	9
41	R:R:N67	R:R:W151	6.78	No	Yes	0	9	9
42	R:R:D72	R:R:L68	5.43	Yes	No	3	9	9
43	R:R:L117	R:R:L68	5.54	No	No	0	8	9
44	R:R:L68	R:R:N322	8.24	No	Yes	3	9	9
45	R:R:D72	R:R:S113	4.42	Yes	No	0	9	9
46	R:R:D72	R:R:S319	11.78	Yes	No	0	9	9
47	R:R:D72	R:R:N322	6.73	Yes	Yes	3	9	9
48	R:R:L75	R:R:V79	4.47	Yes	Yes	1	8	8
49	R:R:C109	R:R:L75	6.35	No	Yes	0	6	8
50	R:R:C110	R:R:L75	3.17	No	Yes	0	6	8
51	R:R:L75	R:R:Y316	7.03	Yes	Yes	1	8	7
52	R:R:S77	R:R:T78	6.4	No	No	0	5	6
53	R:R:T78	R:R:V79	3.17	No	Yes	0	6	8
54	R:R:V79	R:R:W102	6.13	Yes	Yes	0	8	5
55	R:R:V105	R:R:V79	3.21	No	Yes	0	5	8
56	R:R:D106	R:R:V79	7.3	No	Yes	1	7	8
57	R:R:V79	R:R:Y316	3.79	Yes	Yes	1	8	7
58	R:R:L80	R:R:W313	3.42	Yes	Yes	1	8	6
59	R:R:L80	R:R:Y316	11.72	Yes	Yes	1	8	7
60	R:R:F82	R:R:W92	4.01	No	Yes	2	5	8
61	R:R:F82	R:R:F94	4.29	No	Yes	2	5	5
62	R:R:S83	R:R:W102	4.94	No	Yes	0	7	5
63	R:R:S83	R:R:W313	4.94	No	Yes	1	7	6
64	R:R:S83	R:R:Y316	5.09	No	Yes	1	7	7
65	R:R:F86	R:R:W92	4.01	No	Yes	0	4	8
66	R:R:E87	R:R:K309	8.1	No	No	0	5	5
67	R:R:L89	R:R:Y91	8.21	Yes	No	0	5	4
68	R:R:A93	R:R:Y91	4	No	No	0	3	4
69	R:R:T174	R:R:Y91	3.75	No	No	0	1	4
70	R:R:F94	R:R:W92	9.02	Yes	Yes	2	5	8
71	R:R:C99	R:R:W92	3.92	No	Yes	2	9	8
72	R:R:W102	R:R:W92	11.25	Yes	Yes	0	5	8
73	R:R:C176	R:R:W92	5.22	No	Yes	2	9	8
74	R:R:F94	R:R:F98	3.22	Yes	No	2	5	5
75	R:R:I175	R:R:R96	3.76	Yes	No	0	5	5
76	R:R:C176	R:R:C99	7.28	No	No	2	9	9
77	R:R:D106	R:R:Y316	11.49	No	Yes	1	7	7
78	R:R:S158	R:R:V107	3.23	Yes	No	0	8	6
79	R:R:L108	R:R:W151	4.56	No	Yes	0	6	9
80	R:R:L108	R:R:S158	6.01	No	Yes	0	6	8
81	R:R:C110	R:R:W285	7.84	No	Yes	0	6	8
82	R:R:S192	R:R:T111	6.4	No	No	0	6	7
83	R:R:A112	R:R:W151	7.78	No	Yes	5	8	9
84	R:R:A112	R:R:S154	3.42	No	No	5	8	8
85	R:R:I114	R:R:P196	3.39	No	No	0	8	9
86	R:R:F281	R:R:I114	3.77	Yes	No	1	9	8
87	R:R:I114	R:R:W285	11.74	No	Yes	1	8	8
88	R:R:M115	R:R:V150	7.61	No	No	0	6	6
89	R:R:L153	R:R:M115	5.65	No	No	0	5	6
90	R:R:G116	R:R:I119	3.53	No	No	0	7	7
91	R:R:F281	R:R:L117	3.65	Yes	No	0	9	8
92	R:R:L117	R:R:Y326	7.03	No	Yes	0	8	9
93	R:R:C118	R:R:P196	3.77	No	No	0	6	9
94	R:R:C118	R:R:I199	4.91	No	No	0	6	6
95	R:R:C118	R:R:I200	3.27	No	No	0	6	8
96	R:R:I119	R:R:V150	3.07	No	No	0	7	6
97	R:R:I120	R:R:R124	5.01	No	Yes	3	9	9
98	R:R:I120	R:R:Y326	4.84	No	Yes	3	9	9
99	R:R:I200	R:R:S121	9.29	No	No	0	8	9
100	R:R:M203	R:R:S121	3.07	No	No	0	6	9
101	R:R:S121	R:R:Y204	10.17	No	Yes	0	9	9
102	R:R:D123	R:R:Y134	5.75	No	Yes	0	9	7
103	R:R:R124	R:R:Y204	8.23	Yes	Yes	0	9	9
104	R:R:R124	R:R:Y326	6.17	Yes	Yes	3	9	9
105	R:R:R124	R:R:S329	5.27	Yes	No	0	9	7
106	R:R:I126	R:R:Y125	3.63	No	Yes	0	5	8
107	R:R:S129	R:R:Y125	7.63	No	Yes	0	7	8
108	R:R:M203	R:R:Y125	15.57	No	Yes	0	6	8
109	R:R:R206	R:R:Y125	7.2	No	Yes	0	6	8
110	R:R:I126	R:R:V138	3.07	No	Yes	0	5	6
111	R:R:V128	R:R:V207	4.81	No	No	0	8	9
112	R:R:S129	R:R:Y130	7.63	No	No	0	7	6
113	R:R:R133	R:R:Y130	6.17	No	No	0	5	6
114	R:R:P135	R:R:Y134	5.56	No	Yes	0	6	7
115	R:R:V138	R:R:Y134	6.31	Yes	Yes	0	6	7
116	R:R:R142	R:R:T139	3.88	No	No	0	6	7
117	R:R:M145	R:R:R141	3.72	No	No	0	3	5
118	R:R:S154	R:R:W151	4.94	No	Yes	5	8	9
119	R:R:I159	R:R:S158	7.74	No	Yes	0	4	8
120	R:R:I159	R:R:L162	4.28	No	No	0	4	5
121	R:R:G160	R:R:P161	4.06	No	No	0	7	7
122	R:R:N179	R:R:P161	9.77	No	No	7	5	7
123	R:R:P161	R:R:Y184	16.69	No	Yes	7	7	8
124	R:R:F163	R:R:G164	4.52	No	No	0	4	5
125	R:R:E181	R:R:W165	3.27	No	No	0	6	6
126	R:R:W165	R:R:Y184	5.79	No	Yes	0	6	8
127	R:R:N179	R:R:R166	13.26	No	No	0	5	5
128	R:R:P168	R:R:Q167	7.9	No	No	0	4	5
129	R:R:I175	R:R:P170	5.08	Yes	No	6	5	4
130	R:R:P170	R:R:Q177	6.32	No	No	6	4	5
131	R:R:D172	R:R:I175	8.4	No	Yes	0	3	5
132	R:R:E173	R:R:T174	8.47	No	No	0	4	1
133	R:R:I175	R:R:Q177	10.98	Yes	No	6	5	5
134	R:R:E180	R:R:I178	4.1	No	No	0	5	6
135	R:R:F312	R:R:I178	3.77	No	No	1	6	6
136	R:R:N179	R:R:Y184	4.65	No	Yes	7	5	8
137	R:R:E180	R:R:M292	5.41	No	Yes	0	5	7
138	R:R:E181	R:R:P182	4.72	No	No	0	6	4
139	R:R:S296	R:R:V185	6.46	No	No	0	5	6
140	R:R:F193	R:R:Y194	10.32	Yes	No	0	8	6
141	R:R:F193	R:R:L197	8.53	Yes	No	0	8	6
142	R:R:F193	R:R:F281	4.29	Yes	Yes	0	8	9
143	R:R:F193	R:R:L286	3.65	Yes	Yes	0	8	7
144	R:R:F193	R:R:F289	18.22	Yes	Yes	0	8	7
145	R:R:L195	R:R:P196	3.28	No	No	0	5	9
146	R:R:F281	R:R:I200	3.77	Yes	No	0	9	8
147	R:R:M203	R:R:V202	4.56	No	No	0	6	4
148	R:R:V277	R:R:Y204	5.05	No	Yes	0	8	9
149	R:R:V278	R:R:Y204	5.05	No	Yes	0	8	9
150	R:R:K212	R:R:Y208	11.94	No	Yes	8	5	5
151	R:R:E267	R:R:Y208	6.73	No	Yes	8	8	5
152	R:R:A271	R:R:Y208	4	No	Yes	0	7	5
153	R:R:E267	R:R:K212	5.4	No	No	8	8	5
154	R:R:R213	R:R:R266	7.46	No	No	0	5	6
155	R:R:K263	R:R:L262	7.05	No	No	0	5	3
156	R:R:F264	R:R:K268	11.17	No	No	0	4	5
157	R:R:C280	R:R:I321	4.91	No	No	0	7	6
158	R:R:C280	R:R:I325	3.27	No	No	0	7	8
159	R:R:F281	R:R:W285	7.02	Yes	Yes	1	9	8
160	R:R:L286	R:R:V282	4.47	Yes	No	0	7	5
161	R:R:C284	R:R:N318	9.45	No	No	0	8	9
162	R:R:F289	R:R:W285	4.01	Yes	Yes	1	7	8
163	R:R:G315	R:R:W285	8.44	No	Yes	0	7	8
164	R:R:N318	R:R:W285	13.56	No	Yes	0	9	8
165	R:R:L286	R:R:P287	3.28	Yes	No	0	7	9
166	R:R:P287	R:R:V311	3.53	No	No	0	9	5
167	R:R:L314	R:R:P287	3.28	No	No	0	7	9
168	R:R:F288	R:R:F289	7.5	No	Yes	1	7	7
169	R:R:F288	R:R:M292	7.46	No	Yes	0	7	7
170	R:R:V291	R:R:V311	4.81	No	No	0	5	5
171	R:R:M292	R:R:P293	3.35	Yes	No	0	7	6
172	R:R:F297	R:R:F298	9.65	No	Yes	0	5	4
173	R:R:F301	R:R:P303	11.56	No	Yes	0	3	4
174	R:R:S304	R:R:T306	6.4	No	No	0	5	1
175	R:R:K309	R:R:W313	4.64	No	Yes	0	5	6
176	R:R:F312	R:R:Y316	8.25	No	Yes	1	6	7
177	R:R:W313	R:R:Y316	5.79	Yes	Yes	1	6	7
178	R:R:N318	R:R:N322	5.45	No	Yes	0	9	9
179	R:R:N322	R:R:Y326	3.49	Yes	Yes	3	9	9
180	R:R:I325	R:R:Y326	3.63	No	Yes	0	8	9
181	R:R:F333	R:R:P327	4.33	Yes	No	0	8	7
182	R:R:C328	R:R:K334	3.23	No	No	0	5	8
183	R:R:F333	R:R:S330	5.28	Yes	No	0	8	8
184	R:R:M292	R:R:V185	3.04	Yes	No	0	7	6
185	R:R:M115	R:R:T111	3.01	No	No	0	6	7
186	R:R:L155	R:R:S158	3	No	Yes	0	4	8
187	R:R:L274	R:R:V207	2.98	No	No	0	9	9
188	R:R:L274	R:R:V277	2.98	No	No	0	9	8
189	R:R:L80	R:R:T76	2.95	Yes	No	0	8	7
190	R:R:I122	R:R:I199	2.94	No	No	0	6	6
191	R:R:A336	R:R:H54	2.93	No	No	0	7	6
192	R:R:G127	R:R:Y134	2.9	No	Yes	0	8	7
193	R:R:E305	R:R:S304	2.87	No	No	0	2	5
194	R:R:I27	R:R:L28	2.85	No	No	0	6	4
195	R:R:I37	R:R:L38	2.85	Yes	No	0	5	4
196	R:R:I45	R:R:L42	2.85	No	No	0	4	4
197	R:R:I45	R:R:L73	2.85	No	No	0	4	7
198	R:R:I48	R:R:L49	2.85	No	No	0	7	4
199	R:R:I157	R:R:L153	2.85	No	No	0	6	5
200	R:R:E214	R:R:V209	2.85	No	No	0	7	4
201	R:R:K25	R:R:L29	2.82	No	No	0	3	5
202	L:L:?1	R:R:S188	2.79	Yes	No	0	0	7
203	R:R:L317	R:R:L36	2.77	No	No	0	5	7
204	R:R:A169	R:R:R166	2.77	No	No	0	3	5
205	R:R:A189	R:R:F289	2.77	No	Yes	0	7	7
206	R:R:L197	R:R:L201	2.77	No	No	0	6	5
207	R:R:L286	R:R:L290	2.77	Yes	No	0	7	6
208	R:R:L73	R:R:N44	2.75	No	No	0	7	9
209	R:R:A270	R:R:Y208	2.67	No	Yes	0	8	5
210	R:R:F337	R:R:V47	2.62	No	No	0	7	9
211	R:R:A71	R:R:W151	2.59	No	Yes	0	8	9
212	R:R:R133	R:R:T136	2.59	No	No	0	5	4
213	R:R:S188	R:R:Y184	2.54	No	Yes	0	7	8
214	R:R:F298	R:R:I294	2.51	Yes	No	0	4	5
215	R:R:F308	R:R:M292	2.49	No	Yes	0	4	7
216	R:R:N100	R:R:R96	2.41	No	No	0	6	5
217	R:R:L144	R:R:Y63	2.34	No	No	0	5	5
218	R:R:L190	R:R:Y194	2.34	No	No	0	4	6
219	R:R:L36	R:R:W313	2.28	No	Yes	0	7	6
220	R:R:Q140	R:R:Y63	2.25	No	No	0	4	5
221	R:R:G34	R:R:G35	2.11	No	No	0	3	5
222	R:R:A169	R:R:P170	1.87	No	No	0	3	4
223	R:R:G30	R:R:V88	1.84	No	No	0	6	5
224	R:R:G143	R:R:V60	1.84	No	Yes	0	7	7
225	R:R:G275	R:R:V278	1.84	No	No	0	6	8
226	R:R:G279	R:R:V278	1.84	No	No	0	5	8
227	R:R:A211	R:R:A270	1.79	No	No	0	8	8
228	R:R:P303	R:R:V291	1.77	Yes	No	0	4	5
229	R:R:P303	R:R:V307	1.77	Yes	No	0	4	5
230	R:R:G34	R:R:I37	1.76	No	Yes	0	3	5
231	R:R:G295	R:R:I294	1.76	No	No	0	4	5
232	R:R:G30	R:R:L33	1.71	No	Yes	0	6	7
233	R:R:A336	R:R:S50	1.71	No	No	0	7	8
234	R:R:G90	R:R:L89	1.71	No	Yes	0	4	5
235	R:R:G191	R:R:L190	1.71	No	No	0	5	4
236	R:R:A26	R:R:V88	1.7	No	No	0	4	5
237	R:R:I37	R:R:P81	1.69	Yes	No	0	5	9
238	R:R:K302	R:R:P303	1.67	No	Yes	0	3	4
239	R:R:A104	R:R:I159	1.62	No	No	0	6	4
240	R:R:S304	R:R:V307	1.62	No	No	0	5	5
241	R:R:C109	R:R:L74	1.59	No	No	0	6	6
242	R:R:I32	R:R:V31	1.54	No	No	0	5	5
243	R:R:I45	R:R:V41	1.54	No	No	0	4	6
244	R:R:I101	R:R:V105	1.54	No	No	0	5	5
245	R:R:I137	R:R:V138	1.54	No	Yes	0	5	6
246	R:R:I276	R:R:V277	1.54	No	No	0	7	8
247	R:R:F39	R:R:G40	1.51	No	No	0	5	8
248	R:R:F94	R:R:G95	1.51	Yes	No	2	5	8
249	R:R:F98	R:R:G95	1.51	No	No	2	5	8
250	R:R:L46	R:R:V340	1.49	No	No	0	7	6
251	R:R:L74	R:R:V70	1.49	No	No	0	6	6
252	R:R:L89	R:R:V88	1.49	Yes	No	0	5	5
253	R:R:L341	R:R:V340	1.49	No	No	0	7	6
254	R:R:F298	R:R:P299	1.44	Yes	No	0	4	2
255	R:R:Q140	R:R:V60	1.43	No	Yes	0	4	7
256	R:R:I85	R:R:L89	1.43	No	Yes	0	5	5
257	R:R:E214	R:R:V210	1.43	No	No	0	7	6
258	R:R:I310	R:R:L314	1.43	No	No	0	5	7
259	R:R:G164	R:R:W165	1.41	No	No	0	5	6
260	R:R:P131	R:R:Y130	1.39	No	No	0	8	6
261	R:R:K334	R:R:Q338	1.36	No	No	0	8	5
262	R:R:A146	R:R:Y64	1.33	No	Yes	0	6	8
263	R:R:A103	R:R:W102	1.3	No	Yes	0	6	5
264	R:R:R141	R:R:T139	1.29	No	No	0	5	7
265	R:R:E181	R:R:Q167	1.27	No	No	0	6	5
266	R:R:E332	R:R:Q331	1.27	No	No	0	7	5
267	R:R:F187	R:R:I157	1.26	No	No	0	5	6
268	R:R:F301	R:R:I294	1.26	No	No	0	3	5
269	R:R:D300	R:R:F298	1.19	No	Yes	0	1	4
270	R:R:D300	R:R:F301	1.19	No	No	0	1	3
271	R:R:L274	R:R:Y208	1.17	No	Yes	0	9	5
272	R:R:H56	R:R:R55	1.13	No	No	0	6	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	9.08667	9	1	0
2	R:R:L33	5.92	4	0	7
3	R:R:I37	3.544	5	0	5
4	R:R:L57	5.4275	4	4	8
5	R:R:V60	3.2825	4	0	7
6	R:R:Y64	4.83	4	0	8
7	R:R:D72	7.018	5	3	9
8	R:R:L75	5.255	4	1	8
9	R:R:V79	4.67833	6	1	8
10	R:R:L80	6.3075	4	1	8
11	R:R:L89	3.21	4	0	5
12	R:R:W92	6.23833	6	2	8
13	R:R:F94	4.51	4	2	5
14	R:R:W102	5.905	4	0	5
15	R:R:R124	6.17	4	3	9
16	R:R:Y125	8.5075	4	0	8
17	R:R:Y134	5.13	4	0	7
18	R:R:V138	3.9325	4	0	6
19	R:R:W151	5.33	5	5	9
20	R:R:S158	4.995	4	0	8
21	R:R:I175	7.055	4	6	5
22	R:R:Y184	7.4175	4	7	8
23	R:R:F193	9.002	5	0	8
24	R:R:Y204	7.125	4	0	9
25	R:R:Y208	5.302	5	8	5
26	R:R:F281	4.5	5	1	9
27	R:R:W285	8.76833	6	1	8
28	R:R:L286	3.5425	4	0	7
29	R:R:F289	7.63	5	1	7
30	R:R:M292	4.35	5	0	7
31	R:R:F298	3.6975	4	0	4
32	R:R:P303	4.1925	4	0	4
33	R:R:W313	5.41	6	1	6
34	R:R:Y316	7.18875	8	1	7
35	R:R:N322	5.9775	4	3	9
36	R:R:Y326	5.032	5	3	9
37	R:R:F333	6.04167	6	4	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y316	57.2532	4.35	Yes	Yes	1	0	7
2	R:R:L80	R:R:Y316	16.4871	11.72	Yes	Yes	1	8	7
3	R:R:I37	R:R:L80	12.338	7.14	Yes	Yes	0	5	8
4	R:R:W313	R:R:Y316	43.4056	5.79	Yes	Yes	1	6	7
5	R:R:L33	R:R:W313	27.8696	11.39	Yes	Yes	0	7	6
6	R:R:L36	R:R:W313	11.736	2.28	No	Yes	0	7	6
7	L:L:?1	R:R:C110	34.6669	5.89	Yes	No	0	0	6
8	R:R:C110	R:R:W285	58.7453	7.84	No	Yes	0	6	8
9	R:R:N318	R:R:W285	19.2138	13.56	No	Yes	0	9	8
10	R:R:N318	R:R:N322	16.7008	5.45	No	Yes	0	9	9
11	R:R:D72	R:R:N322	12.2115	6.73	Yes	Yes	3	9	9
12	R:R:D72	R:R:N44	11.5702	6.73	Yes	No	0	9	9
13	L:L:?1	R:R:F289	73.0117	5.65	Yes	Yes	1	0	7
14	R:R:F289	R:R:W285	38.2924	4.01	Yes	Yes	1	7	8
15	R:R:F281	R:R:W285	72.2918	7.02	Yes	Yes	1	9	8
16	R:R:F281	R:R:I200	100	3.77	Yes	No	0	9	8
17	R:R:I200	R:R:S121	96.6843	9.29	No	No	0	8	9
18	R:R:M203	R:R:S121	83.6307	3.07	No	No	0	6	9
19	R:R:M203	R:R:Y125	80.9694	15.57	No	Yes	0	6	8
20	R:R:I126	R:R:Y125	71.38	3.63	No	Yes	0	5	8
21	R:R:I126	R:R:V138	69.9577	3.07	No	Yes	0	5	6
22	R:R:V138	R:R:Y134	40.7487	6.31	Yes	Yes	0	6	7
23	R:R:D123	R:R:Y134	36.255	5.75	No	Yes	0	9	7
24	R:R:D123	R:R:T61	36.1503	10.12	No	No	0	9	8
25	R:R:S59	R:R:T61	34.8021	3.2	No	No	0	7	8
26	R:R:H62	R:R:S59	33.1792	13.95	No	No	0	8	7
27	R:R:F333	R:R:H62	19.7766	9.05	Yes	No	4	8	8
28	R:R:F333	R:R:P327	12.1068	4.33	Yes	No	0	8	7
29	R:R:P327	R:R:V47	10.3573	3.53	No	No	0	7	9
30	R:R:F193	R:R:F289	45.5259	18.22	Yes	Yes	0	8	7
31	R:R:F193	R:R:F281	41.7259	4.29	Yes	Yes	0	8	9
32	R:R:C110	R:R:L75	27.8566	3.17	No	Yes	0	6	8
33	R:R:L75	R:R:Y316	16.823	7.03	Yes	Yes	1	8	7
34	R:R:H62	R:R:L57	11.7491	9	No	Yes	4	8	8
35	R:R:V138	R:R:V60	26.7222	4.81	Yes	Yes	0	6	7
36	R:R:V60	R:R:Y64	18.3282	5.05	Yes	Yes	0	7	8
37	R:R:I119	R:R:Y64	15.8588	6.04	No	Yes	0	7	8
38	L:L:?1	R:R:V107	25.9718	12.44	Yes	No	0	0	6
39	R:R:S158	R:R:V107	24.026	3.23	Yes	No	0	8	6
40	R:R:L108	R:R:S158	14.166	6.01	No	Yes	0	6	8
41	R:R:L108	R:R:W151	12.1679	4.56	No	Yes	0	6	9
42	R:R:F281	R:R:L117	16.6049	3.65	Yes	No	0	9	8
43	R:R:V79	R:R:W102	12.1417	6.13	Yes	Yes	0	8	5
44	R:R:W102	R:R:W92	13.9043	11.25	Yes	Yes	0	5	8
45	R:R:G30	R:R:L33	23.5461	1.71	No	Yes	0	6	7
46	R:R:G30	R:R:V88	21.1858	1.84	No	No	0	6	5
47	R:R:L89	R:R:V88	16.8535	1.49	Yes	No	0	5	5
48	L:L:?1	R:R:S188	38.5149	2.79	Yes	No	0	0	7
49	R:R:S188	R:R:Y184	36.796	2.54	No	Yes	0	7	8
50	R:R:N179	R:R:Y184	17.3902	4.65	No	Yes	7	5	8
51	R:R:N179	R:R:R166	15.8239	13.26	No	No	0	5	5
52	R:R:A169	R:R:R166	13.8345	2.77	No	No	0	3	5
53	R:R:A169	R:R:P170	12.1679	1.87	No	No	0	3	4
54	R:R:I119	R:R:V150	12.3947	3.07	No	No	0	7	6
55	R:R:M115	R:R:V150	10.6496	7.61	No	No	0	6	6
56	R:R:S121	R:R:Y204	27.2458	10.17	No	Yes	0	9	9
57	R:R:V277	R:R:Y204	17.7305	5.05	No	Yes	0	8	9
58	R:R:L274	R:R:V277	14.454	2.98	No	No	0	9	8
59	R:R:W165	R:R:Y184	14.166	5.79	No	Yes	0	6	8
60	R:R:F193	R:R:L286	26.8226	3.65	Yes	Yes	0	8	7
61	R:R:L286	R:R:P287	23.7075	3.28	Yes	No	0	7	9
62	R:R:P287	R:R:V311	20.6579	3.53	No	No	0	9	5
63	R:R:V291	R:R:V311	19.5759	4.81	No	No	0	5	5
64	R:R:P303	R:R:V291	18.4852	1.77	Yes	No	0	4	5
65	R:R:F301	R:R:P303	11.9061	11.56	No	Yes	0	3	4

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:D106	12.59	1	Yes	No	0	7	0	1
L:L:?1	R:R:V107	12.44	1	Yes	No	0	6	0	1
L:L:?1	R:R:C110	5.89	1	Yes	No	0	6	0	1
L:L:?1	R:R:I178	5.3	1	Yes	No	0	6	0	1
L:L:?1	R:R:F288	21.47	1	Yes	No	0	7	0	1
L:L:?1	R:R:F289	5.65	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:F312	11.3	1	Yes	No	0	6	0	1
L:L:?1	R:R:Y316	4.35	1	Yes	Yes	0	7	0	1
R:R:L75	R:R:V79	4.47	1	Yes	Yes	8	8	2	2
R:R:C110	R:R:L75	3.17	0	No	Yes	6	8	1	2
R:R:L75	R:R:Y316	7.03	1	Yes	Yes	8	7	2	1
R:R:D106	R:R:V79	7.3	1	No	Yes	7	8	1	2
R:R:V79	R:R:Y316	3.79	1	Yes	Yes	8	7	2	1
R:R:L80	R:R:W313	3.42	1	Yes	Yes	8	6	2	2
R:R:L80	R:R:Y316	11.72	1	Yes	Yes	8	7	2	1
R:R:S83	R:R:W313	4.94	1	No	Yes	7	6	2	2
R:R:S83	R:R:Y316	5.09	1	No	Yes	7	7	2	1
R:R:D106	R:R:Y316	11.49	1	No	Yes	7	7	1	1
R:R:S158	R:R:V107	3.23	0	Yes	No	8	6	2	1
R:R:C110	R:R:W285	7.84	0	No	Yes	6	8	1	2
R:R:E180	R:R:I178	4.1	0	No	No	5	6	2	1
R:R:F312	R:R:I178	3.77	1	No	No	6	6	1	1
R:R:E180	R:R:M292	5.41	0	No	Yes	5	7	2	2
R:R:F193	R:R:F289	18.22	0	Yes	Yes	8	7	2	1
R:R:F289	R:R:W285	4.01	1	Yes	Yes	7	8	1	2
R:R:F288	R:R:F289	7.5	1	No	Yes	7	7	1	1
R:R:F288	R:R:M292	7.46	1	No	Yes	7	7	1	2
R:R:F312	R:R:Y316	8.25	1	No	Yes	6	7	1	1
R:R:W313	R:R:Y316	5.79	1	Yes	Yes	6	7	2	1
L:L:?1	R:R:S188	2.79	1	Yes	No	0	7	0	1
R:R:A189	R:R:F289	2.77	0	No	Yes	7	7	2	1
R:R:S188	R:R:Y184	2.54	0	No	Yes	7	8	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7YMH_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.07
Number of Linked Nodes	251
Number of Links	272
Number of Hubs	37
Number of Links mediated by Hubs	149
Number of Communities	8
Number of Nodes involved in Communities	43
Number of Links involved in Communities	54

Path Summary
Number Of Nodes in MetaPath	66
Number Of Links MetaPath	65
Number of Shortest Paths	47405
Length Of Smallest Path	3
Average Path Length	13.3773
Length of Longest Path	31
Minimum Path Strength	1.19
Average Path Strength	6.01804
Maximum Path Strength	17.03
Minimum Path Correlation	0.7
Average Path Correlation	0.912674
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.16667
Average % Of Corr. Nodes	43.1131
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	47.5883
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	E5E
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	E5E
Name	Noradrenaline
Synonyms
Identifier
Formula	C8 H12 N O3
Molecular Weight	170.186
SMILES
PubChem	6921840
Formal Charge	1
Total Atoms	24
Total Chiral Atoms	1
Total Bonds	24
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P35348
Sequence	>7YMH_nogp_Chain_R K A I L L G V I L G G L I L F G V L G N I L V I L S V A C H R H L H S V T H Y Y I V N L A V A D L L L T S T V L P F S A I F E V L G Y W A F G R V F C N I W A A V D V L C C T A S I M G L C I I S I D R Y I G V S Y P L R Y P T I V T Q R R G L M A L L C V W A L S L V I S I G P L F G W R Q P A P E D E T I C Q I N E E P G Y V L F S A L G S F Y L P L A I I L V M Y C R V Y V V A K R E L K F S R E K K A A K T L G I V V G C F V L C W L P F F L V M P I G S F F P D F K P S E T V F K I V F W L G Y L N S C I N P I I Y P C S S Q E F K K A F Q N V L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7YM8	A	Amine	Adrenergic	Alpha1A	Homo sapiens	Oxymetazoline	-	chim(Gs-CtGq)	2.92	2023-07-05	doi.org/10.1038/s41467-023-39310-x
	7YM8 (No Gprot)	A	Amine	Adrenergic	Alpha1A	Homo sapiens	Oxymetazoline	-		2.92	2023-07-05	doi.org/10.1038/s41467-023-39310-x
	7YMH	A	Amine	Adrenergic	Alpha1A	Homo sapiens	Norepinephrine	-	chim(Gs-CtGq)	3.52	2023-07-05	doi.org/10.1038/s41467-023-39310-x
	7YMH (No Gprot)	A	Amine	Adrenergic	Alpha1A	Homo sapiens	Norepinephrine	-		3.52	2023-07-05	doi.org/10.1038/s41467-023-39310-x
	7YMJ	A	Amine	Adrenergic	Alpha1A	Homo sapiens	Tamsulosin	-	-	3.35	2023-07-05	doi.org/10.1038/s41467-023-39310-x
	8THK	A	Amine	Adrenergic	Alpha1A	Homo sapiens	A-61603	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	2.6	2023-08-16	doi.org/10.1038/s41467-023-40524-2
	8THK (No Gprot)	A	Amine	Adrenergic	Alpha1A	Homo sapiens	A-61603	-		2.6	2023-08-16	doi.org/10.1038/s41467-023-40524-2
	8THL	A	Amine	Adrenergic	Alpha1A	Homo sapiens	Epinephrine	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.1	2023-08-16	doi.org/10.1038/s41467-023-40524-2
	8THL (No Gprot)	A	Amine	Adrenergic	Alpha1A	Homo sapiens	Epinephrine	-		3.1	2023-08-16	doi.org/10.1038/s41467-023-40524-2
	8HN1	A	Amine	Adrenergic	Alpha1A	Homo sapiens	Toxin AdTx1	-	-	2.9	2023-12-20	To be published
	9M4Q	A	Amine	Adrenergic	Alpha1A	Homo sapiens	Doxazosin	-	-	2.99	2025-07-02	doi.org/10.1016/j.jbc.2025.110348
	9M4T	A	Amine	Adrenergic	Alpha1A	Homo sapiens	Silodosin	-	-	3.19	2025-07-02	doi.org/10.1016/j.jbc.2025.110348
	9IQV	A	Amine	Adrenergic	Alpha1A	Homo sapiens	-	Muscarinic toxin 3	-	3.3	2025-07-23	To be published

2D representation of the interactions of this orthosteric/allosteric ligand.

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Data downloads are temporarily suspended for technical reasons. We apologize for the inconvenience.

Data downloads are temporarily suspended for technical reasons.
We apologize for the inconvenience.