psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D106	12.59	Yes	No	1	0	7
2	L:L:?1	R:R:V107	12.44	Yes	No	0	0	6
3	L:L:?1	R:R:C110	5.89	Yes	No	0	0	6
4	L:L:?1	R:R:I178	5.3	Yes	No	1	0	6
5	L:L:?1	R:R:F288	21.47	Yes	No	1	0	7
6	L:L:?1	R:R:F289	5.65	Yes	Yes	1	0	7
7	L:L:?1	R:R:F312	11.3	Yes	No	1	0	6
8	L:L:?1	R:R:Y316	4.35	Yes	Yes	1	0	7
9	R:R:K25	R:R:L28	4.23	No	No	0	3	4
10	R:R:I37	R:R:L33	4.28	Yes	Yes	0	5	7
11	R:R:A84	R:R:L33	6.3	No	Yes	0	6	7
12	R:R:L33	R:R:W313	11.39	Yes	Yes	0	7	6
13	R:R:C320	R:R:L36	6.35	No	No	0	6	7
14	R:R:I37	R:R:L80	7.14	Yes	Yes	0	5	8
15	R:R:C320	R:R:G40	3.92	No	No	0	6	8
16	R:R:G43	R:R:P323	4.06	No	No	0	9	9
17	R:R:D72	R:R:N44	6.73	Yes	No	0	9	9
18	R:R:N44	R:R:P323	9.77	No	No	0	9	9
19	R:R:F337	R:R:L46	12.18	No	No	0	7	7
20	R:R:A69	R:R:V47	3.39	No	No	0	9	9
21	R:R:P327	R:R:V47	3.53	No	No	0	7	9
22	R:R:I48	R:R:V70	3.07	No	No	0	7	6
23	R:R:V51	R:R:V66	4.81	No	No	0	8	6
24	R:R:F333	R:R:V51	3.93	Yes	No	0	8	8
25	R:R:C53	R:R:H54	7.37	No	No	0	5	6
26	R:R:H54	R:R:L57	3.86	No	Yes	0	6	8
27	R:R:H62	R:R:L57	9	No	Yes	4	8	8
28	R:R:E332	R:R:L57	3.98	No	Yes	0	7	8
29	R:R:F333	R:R:L57	4.87	Yes	Yes	4	8	8
30	R:R:H58	R:R:Y63	14.16	No	No	0	8	5
31	R:R:S59	R:R:T61	3.2	No	No	0	7	8
32	R:R:H62	R:R:S59	13.95	No	No	0	8	7
33	R:R:V60	R:R:Y64	5.05	Yes	Yes	0	7	8
34	R:R:V138	R:R:V60	4.81	Yes	Yes	0	6	7
35	R:R:D123	R:R:T61	10.12	No	No	0	9	8
36	R:R:F333	R:R:H62	9.05	Yes	No	4	8	8
37	R:R:I119	R:R:Y64	6.04	No	Yes	0	7	8
38	R:R:D123	R:R:Y64	6.9	No	Yes	0	9	8
39	R:R:F333	R:R:I65	8.79	Yes	No	0	8	7
40	R:R:L147	R:R:N67	8.24	No	No	0	8	9
41	R:R:N67	R:R:W151	6.78	No	Yes	0	9	9
42	R:R:D72	R:R:L68	5.43	Yes	No	3	9	9
43	R:R:L117	R:R:L68	5.54	No	No	0	8	9
44	R:R:L68	R:R:N322	8.24	No	Yes	3	9	9
45	R:R:D72	R:R:S113	4.42	Yes	No	0	9	9
46	R:R:D72	R:R:S319	11.78	Yes	No	0	9	9
47	R:R:D72	R:R:N322	6.73	Yes	Yes	3	9	9
48	R:R:L75	R:R:V79	4.47	Yes	Yes	1	8	8
49	R:R:C109	R:R:L75	6.35	No	Yes	0	6	8
50	R:R:C110	R:R:L75	3.17	No	Yes	0	6	8
51	R:R:L75	R:R:Y316	7.03	Yes	Yes	1	8	7
52	R:R:S77	R:R:T78	6.4	No	No	0	5	6
53	R:R:T78	R:R:V79	3.17	No	Yes	0	6	8
54	R:R:V79	R:R:W102	6.13	Yes	Yes	0	8	5
55	R:R:V105	R:R:V79	3.21	No	Yes	0	5	8
56	R:R:D106	R:R:V79	7.3	No	Yes	1	7	8
57	R:R:V79	R:R:Y316	3.79	Yes	Yes	1	8	7
58	R:R:L80	R:R:W313	3.42	Yes	Yes	1	8	6
59	R:R:L80	R:R:Y316	11.72	Yes	Yes	1	8	7
60	R:R:F82	R:R:W92	4.01	No	Yes	2	5	8
61	R:R:F82	R:R:F94	4.29	No	Yes	2	5	5
62	R:R:S83	R:R:W102	4.94	No	Yes	0	7	5
63	R:R:S83	R:R:W313	4.94	No	Yes	1	7	6
64	R:R:S83	R:R:Y316	5.09	No	Yes	1	7	7
65	R:R:F86	R:R:W92	4.01	No	Yes	0	4	8
66	R:R:E87	R:R:K309	8.1	No	No	0	5	5
67	R:R:L89	R:R:Y91	8.21	Yes	No	0	5	4
68	R:R:A93	R:R:Y91	4	No	No	0	3	4
69	R:R:T174	R:R:Y91	3.75	No	No	0	1	4
70	R:R:F94	R:R:W92	9.02	Yes	Yes	2	5	8
71	R:R:C99	R:R:W92	3.92	No	Yes	2	9	8
72	R:R:W102	R:R:W92	11.25	Yes	Yes	0	5	8
73	R:R:C176	R:R:W92	5.22	No	Yes	2	9	8
74	R:R:F94	R:R:F98	3.22	Yes	No	2	5	5
75	R:R:I175	R:R:R96	3.76	Yes	No	0	5	5
76	R:R:C176	R:R:C99	7.28	No	No	2	9	9
77	R:R:D106	R:R:Y316	11.49	No	Yes	1	7	7
78	R:R:S158	R:R:V107	3.23	Yes	No	0	8	6
79	R:R:L108	R:R:W151	4.56	No	Yes	0	6	9
80	R:R:L108	R:R:S158	6.01	No	Yes	0	6	8
81	R:R:C110	R:R:W285	7.84	No	Yes	0	6	8
82	R:R:S192	R:R:T111	6.4	No	No	0	6	7
83	R:R:A112	R:R:W151	7.78	No	Yes	5	8	9
84	R:R:A112	R:R:S154	3.42	No	No	5	8	8
85	R:R:I114	R:R:P196	3.39	No	No	0	8	9
86	R:R:F281	R:R:I114	3.77	Yes	No	1	9	8
87	R:R:I114	R:R:W285	11.74	No	Yes	1	8	8
88	R:R:M115	R:R:V150	7.61	No	No	0	6	6
89	R:R:L153	R:R:M115	5.65	No	No	0	5	6
90	R:R:G116	R:R:I119	3.53	No	No	0	7	7
91	R:R:F281	R:R:L117	3.65	Yes	No	0	9	8
92	R:R:L117	R:R:Y326	7.03	No	Yes	0	8	9
93	R:R:C118	R:R:P196	3.77	No	No	0	6	9
94	R:R:C118	R:R:I199	4.91	No	No	0	6	6
95	R:R:C118	R:R:I200	3.27	No	No	0	6	8
96	R:R:I119	R:R:V150	3.07	No	No	0	7	6
97	R:R:I120	R:R:R124	5.01	No	Yes	3	9	9
98	R:R:I120	R:R:Y326	4.84	No	Yes	3	9	9
99	R:R:I200	R:R:S121	9.29	No	No	0	8	9
100	R:R:M203	R:R:S121	3.07	No	No	0	6	9
101	R:R:S121	R:R:Y204	10.17	No	Yes	0	9	9
102	R:R:D123	R:R:Y134	5.75	No	Yes	0	9	7
103	R:R:R124	R:R:Y204	8.23	Yes	Yes	0	9	9
104	R:R:R124	R:R:Y326	6.17	Yes	Yes	3	9	9
105	R:R:R124	R:R:S329	5.27	Yes	No	0	9	7
106	R:R:I126	R:R:Y125	3.63	No	Yes	0	5	8
107	R:R:S129	R:R:Y125	7.63	No	Yes	0	7	8
108	R:R:M203	R:R:Y125	15.57	No	Yes	0	6	8
109	R:R:R206	R:R:Y125	7.2	No	Yes	0	6	8
110	R:R:I126	R:R:V138	3.07	No	Yes	0	5	6
111	R:R:V128	R:R:V207	4.81	No	No	0	8	9
112	R:R:S129	R:R:Y130	7.63	No	No	0	7	6
113	R:R:R133	R:R:Y130	6.17	No	No	0	5	6
114	R:R:P135	R:R:Y134	5.56	No	Yes	0	6	7
115	R:R:V138	R:R:Y134	6.31	Yes	Yes	0	6	7
116	R:R:R142	R:R:T139	3.88	No	No	0	6	7
117	R:R:M145	R:R:R141	3.72	No	No	0	3	5
118	R:R:S154	R:R:W151	4.94	No	Yes	5	8	9
119	R:R:I159	R:R:S158	7.74	No	Yes	0	4	8
120	R:R:I159	R:R:L162	4.28	No	No	0	4	5
121	R:R:G160	R:R:P161	4.06	No	No	0	7	7
122	R:R:N179	R:R:P161	9.77	No	No	7	5	7
123	R:R:P161	R:R:Y184	16.69	No	Yes	7	7	8
124	R:R:F163	R:R:G164	4.52	No	No	0	4	5
125	R:R:E181	R:R:W165	3.27	No	No	0	6	6
126	R:R:W165	R:R:Y184	5.79	No	Yes	0	6	8
127	R:R:N179	R:R:R166	13.26	No	No	0	5	5
128	R:R:P168	R:R:Q167	7.9	No	No	0	4	5
129	R:R:I175	R:R:P170	5.08	Yes	No	6	5	4
130	R:R:P170	R:R:Q177	6.32	No	No	6	4	5
131	R:R:D172	R:R:I175	8.4	No	Yes	0	3	5
132	R:R:E173	R:R:T174	8.47	No	No	0	4	1
133	R:R:I175	R:R:Q177	10.98	Yes	No	6	5	5
134	R:R:E180	R:R:I178	4.1	No	No	0	5	6
135	R:R:F312	R:R:I178	3.77	No	No	1	6	6
136	R:R:N179	R:R:Y184	4.65	No	Yes	7	5	8
137	R:R:E180	R:R:M292	5.41	No	Yes	0	5	7
138	R:R:E181	R:R:P182	4.72	No	No	0	6	4
139	R:R:S296	R:R:V185	6.46	No	No	0	5	6
140	R:R:F193	R:R:Y194	10.32	Yes	No	0	8	6
141	R:R:F193	R:R:L197	8.53	Yes	No	0	8	6
142	R:R:F193	R:R:F281	4.29	Yes	Yes	0	8	9
143	R:R:F193	R:R:L286	3.65	Yes	Yes	0	8	7
144	R:R:F193	R:R:F289	18.22	Yes	Yes	0	8	7
145	R:R:L195	R:R:P196	3.28	No	No	0	5	9
146	R:R:F281	R:R:I200	3.77	Yes	No	0	9	8
147	R:R:M203	R:R:V202	4.56	No	No	0	6	4
148	R:R:V277	R:R:Y204	5.05	No	Yes	0	8	9
149	R:R:V278	R:R:Y204	5.05	No	Yes	0	8	9
150	R:R:K212	R:R:Y208	11.94	No	Yes	8	5	5
151	R:R:E267	R:R:Y208	6.73	No	Yes	8	8	5
152	R:R:A271	R:R:Y208	4	No	Yes	0	7	5
153	R:R:E267	R:R:K212	5.4	No	No	8	8	5
154	R:R:R213	R:R:R266	7.46	No	No	0	5	6
155	R:R:K263	R:R:L262	7.05	No	No	0	5	3
156	R:R:F264	R:R:K268	11.17	No	No	0	4	5
157	R:R:C280	R:R:I321	4.91	No	No	0	7	6
158	R:R:C280	R:R:I325	3.27	No	No	0	7	8
159	R:R:F281	R:R:W285	7.02	Yes	Yes	1	9	8
160	R:R:L286	R:R:V282	4.47	Yes	No	0	7	5
161	R:R:C284	R:R:N318	9.45	No	No	0	8	9
162	R:R:F289	R:R:W285	4.01	Yes	Yes	1	7	8
163	R:R:G315	R:R:W285	8.44	No	Yes	0	7	8
164	R:R:N318	R:R:W285	13.56	No	Yes	0	9	8
165	R:R:L286	R:R:P287	3.28	Yes	No	0	7	9
166	R:R:P287	R:R:V311	3.53	No	No	0	9	5
167	R:R:L314	R:R:P287	3.28	No	No	0	7	9
168	R:R:F288	R:R:F289	7.5	No	Yes	1	7	7
169	R:R:F288	R:R:M292	7.46	No	Yes	0	7	7
170	R:R:V291	R:R:V311	4.81	No	No	0	5	5
171	R:R:M292	R:R:P293	3.35	Yes	No	0	7	6
172	R:R:F297	R:R:F298	9.65	No	Yes	0	5	4
173	R:R:F301	R:R:P303	11.56	No	Yes	0	3	4
174	R:R:S304	R:R:T306	6.4	No	No	0	5	1
175	R:R:K309	R:R:W313	4.64	No	Yes	0	5	6
176	R:R:F312	R:R:Y316	8.25	No	Yes	1	6	7
177	R:R:W313	R:R:Y316	5.79	Yes	Yes	1	6	7
178	R:R:N318	R:R:N322	5.45	No	Yes	0	9	9
179	R:R:N322	R:R:Y326	3.49	Yes	Yes	3	9	9
180	R:R:I325	R:R:Y326	3.63	No	Yes	0	8	9
181	R:R:F333	R:R:P327	4.33	Yes	No	0	8	7
182	R:R:C328	R:R:K334	3.23	No	No	0	5	8
183	R:R:F333	R:R:S330	5.28	Yes	No	0	8	8
184	R:R:M292	R:R:V185	3.04	Yes	No	0	7	6
185	R:R:M115	R:R:T111	3.01	No	No	0	6	7
186	R:R:L155	R:R:S158	3	No	Yes	0	4	8
187	R:R:L274	R:R:V207	2.98	No	No	0	9	9
188	R:R:L274	R:R:V277	2.98	No	No	0	9	8
189	R:R:L80	R:R:T76	2.95	Yes	No	0	8	7
190	R:R:I122	R:R:I199	2.94	No	No	0	6	6
191	R:R:A336	R:R:H54	2.93	No	No	0	7	6
192	R:R:G127	R:R:Y134	2.9	No	Yes	0	8	7
193	R:R:E305	R:R:S304	2.87	No	No	0	2	5
194	R:R:I27	R:R:L28	2.85	No	No	0	6	4
195	R:R:I37	R:R:L38	2.85	Yes	No	0	5	4
196	R:R:I45	R:R:L42	2.85	No	No	0	4	4
197	R:R:I45	R:R:L73	2.85	No	No	0	4	7
198	R:R:I48	R:R:L49	2.85	No	No	0	7	4
199	R:R:I157	R:R:L153	2.85	No	No	0	6	5
200	R:R:E214	R:R:V209	2.85	No	No	0	7	4
201	R:R:K25	R:R:L29	2.82	No	No	0	3	5
202	L:L:?1	R:R:S188	2.79	Yes	No	0	0	7
203	R:R:L317	R:R:L36	2.77	No	No	0	5	7
204	R:R:A169	R:R:R166	2.77	No	No	0	3	5
205	R:R:A189	R:R:F289	2.77	No	Yes	0	7	7
206	R:R:L197	R:R:L201	2.77	No	No	0	6	5
207	R:R:L286	R:R:L290	2.77	Yes	No	0	7	6
208	R:R:L73	R:R:N44	2.75	No	No	0	7	9
209	R:R:A270	R:R:Y208	2.67	No	Yes	0	8	5
210	R:R:F337	R:R:V47	2.62	No	No	0	7	9
211	R:R:A71	R:R:W151	2.59	No	Yes	0	8	9
212	R:R:R133	R:R:T136	2.59	No	No	0	5	4
213	R:R:S188	R:R:Y184	2.54	No	Yes	0	7	8
214	R:R:F298	R:R:I294	2.51	Yes	No	0	4	5
215	R:R:F308	R:R:M292	2.49	No	Yes	0	4	7
216	R:R:N100	R:R:R96	2.41	No	No	0	6	5
217	R:R:L144	R:R:Y63	2.34	No	No	0	5	5
218	R:R:L190	R:R:Y194	2.34	No	No	0	4	6
219	R:R:L36	R:R:W313	2.28	No	Yes	0	7	6
220	R:R:Q140	R:R:Y63	2.25	No	No	0	4	5
221	R:R:G34	R:R:G35	2.11	No	No	0	3	5
222	R:R:A169	R:R:P170	1.87	No	No	0	3	4
223	R:R:G30	R:R:V88	1.84	No	No	0	6	5
224	R:R:G143	R:R:V60	1.84	No	Yes	0	7	7
225	R:R:G275	R:R:V278	1.84	No	No	0	6	8
226	R:R:G279	R:R:V278	1.84	No	No	0	5	8
227	R:R:A211	R:R:A270	1.79	No	No	0	8	8
228	R:R:P303	R:R:V291	1.77	Yes	No	0	4	5
229	R:R:P303	R:R:V307	1.77	Yes	No	0	4	5
230	R:R:G34	R:R:I37	1.76	No	Yes	0	3	5
231	R:R:G295	R:R:I294	1.76	No	No	0	4	5
232	R:R:G30	R:R:L33	1.71	No	Yes	0	6	7
233	R:R:A336	R:R:S50	1.71	No	No	0	7	8
234	R:R:G90	R:R:L89	1.71	No	Yes	0	4	5
235	R:R:G191	R:R:L190	1.71	No	No	0	5	4
236	R:R:A26	R:R:V88	1.7	No	No	0	4	5
237	R:R:I37	R:R:P81	1.69	Yes	No	0	5	9
238	R:R:K302	R:R:P303	1.67	No	Yes	0	3	4
239	R:R:A104	R:R:I159	1.62	No	No	0	6	4
240	R:R:S304	R:R:V307	1.62	No	No	0	5	5
241	R:R:C109	R:R:L74	1.59	No	No	0	6	6
242	R:R:I32	R:R:V31	1.54	No	No	0	5	5
243	R:R:I45	R:R:V41	1.54	No	No	0	4	6
244	R:R:I101	R:R:V105	1.54	No	No	0	5	5
245	R:R:I137	R:R:V138	1.54	No	Yes	0	5	6
246	R:R:I276	R:R:V277	1.54	No	No	0	7	8
247	R:R:F39	R:R:G40	1.51	No	No	0	5	8
248	R:R:F94	R:R:G95	1.51	Yes	No	2	5	8
249	R:R:F98	R:R:G95	1.51	No	No	2	5	8
250	R:R:L46	R:R:V340	1.49	No	No	0	7	6
251	R:R:L74	R:R:V70	1.49	No	No	0	6	6
252	R:R:L89	R:R:V88	1.49	Yes	No	0	5	5
253	R:R:L341	R:R:V340	1.49	No	No	0	7	6
254	R:R:F298	R:R:P299	1.44	Yes	No	0	4	2
255	R:R:Q140	R:R:V60	1.43	No	Yes	0	4	7
256	R:R:I85	R:R:L89	1.43	No	Yes	0	5	5
257	R:R:E214	R:R:V210	1.43	No	No	0	7	6
258	R:R:I310	R:R:L314	1.43	No	No	0	5	7
259	R:R:G164	R:R:W165	1.41	No	No	0	5	6
260	R:R:P131	R:R:Y130	1.39	No	No	0	8	6
261	R:R:K334	R:R:Q338	1.36	No	No	0	8	5
262	R:R:A146	R:R:Y64	1.33	No	Yes	0	6	8
263	R:R:A103	R:R:W102	1.3	No	Yes	0	6	5
264	R:R:R141	R:R:T139	1.29	No	No	0	5	7
265	R:R:E181	R:R:Q167	1.27	No	No	0	6	5
266	R:R:E332	R:R:Q331	1.27	No	No	0	7	5
267	R:R:F187	R:R:I157	1.26	No	No	0	5	6
268	R:R:F301	R:R:I294	1.26	No	No	0	3	5
269	R:R:D300	R:R:F298	1.19	No	Yes	0	1	4
270	R:R:D300	R:R:F301	1.19	No	No	0	1	3
271	R:R:L274	R:R:Y208	1.17	No	Yes	0	9	5
272	R:R:H56	R:R:R55	1.13	No	No	0	6	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	9.08667	9	1	0
2	R:R:L33	5.92	4	0	7
3	R:R:I37	3.544	5	0	5
4	R:R:L57	5.4275	4	4	8
5	R:R:V60	3.2825	4	0	7
6	R:R:Y64	4.83	4	0	8
7	R:R:D72	7.018	5	3	9
8	R:R:L75	5.255	4	1	8
9	R:R:V79	4.67833	6	1	8
10	R:R:L80	6.3075	4	1	8
11	R:R:L89	3.21	4	0	5
12	R:R:W92	6.23833	6	2	8
13	R:R:F94	4.51	4	2	5
14	R:R:W102	5.905	4	0	5
15	R:R:R124	6.17	4	3	9
16	R:R:Y125	8.5075	4	0	8
17	R:R:Y134	5.13	4	0	7
18	R:R:V138	3.9325	4	0	6
19	R:R:W151	5.33	5	5	9
20	R:R:S158	4.995	4	0	8
21	R:R:I175	7.055	4	6	5
22	R:R:Y184	7.4175	4	7	8
23	R:R:F193	9.002	5	0	8
24	R:R:Y204	7.125	4	0	9
25	R:R:Y208	5.302	5	8	5
26	R:R:F281	4.5	5	1	9
27	R:R:W285	8.76833	6	1	8
28	R:R:L286	3.5425	4	0	7
29	R:R:F289	7.63	5	1	7
30	R:R:M292	4.35	5	0	7
31	R:R:F298	3.6975	4	0	4
32	R:R:P303	4.1925	4	0	4
33	R:R:W313	5.41	6	1	6
34	R:R:Y316	7.18875	8	1	7
35	R:R:N322	5.9775	4	3	9
36	R:R:Y326	5.032	5	3	9
37	R:R:F333	6.04167	6	4	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y316	57.2532	4.35	Yes	Yes	1	0	7
2	R:R:L80	R:R:Y316	16.4871	11.72	Yes	Yes	1	8	7
3	R:R:I37	R:R:L80	12.338	7.14	Yes	Yes	0	5	8
4	R:R:W313	R:R:Y316	43.4056	5.79	Yes	Yes	1	6	7
5	R:R:L33	R:R:W313	27.8696	11.39	Yes	Yes	0	7	6
6	R:R:L36	R:R:W313	11.736	2.28	No	Yes	0	7	6
7	L:L:?1	R:R:C110	34.6669	5.89	Yes	No	0	0	6
8	R:R:C110	R:R:W285	58.7453	7.84	No	Yes	0	6	8
9	R:R:N318	R:R:W285	19.2138	13.56	No	Yes	0	9	8
10	R:R:N318	R:R:N322	16.7008	5.45	No	Yes	0	9	9
11	R:R:D72	R:R:N322	12.2115	6.73	Yes	Yes	3	9	9
12	R:R:D72	R:R:N44	11.5702	6.73	Yes	No	0	9	9
13	L:L:?1	R:R:F289	73.0117	5.65	Yes	Yes	1	0	7
14	R:R:F289	R:R:W285	38.2924	4.01	Yes	Yes	1	7	8
15	R:R:F281	R:R:W285	72.2918	7.02	Yes	Yes	1	9	8
16	R:R:F281	R:R:I200	100	3.77	Yes	No	0	9	8
17	R:R:I200	R:R:S121	96.6843	9.29	No	No	0	8	9
18	R:R:M203	R:R:S121	83.6307	3.07	No	No	0	6	9
19	R:R:M203	R:R:Y125	80.9694	15.57	No	Yes	0	6	8
20	R:R:I126	R:R:Y125	71.38	3.63	No	Yes	0	5	8
21	R:R:I126	R:R:V138	69.9577	3.07	No	Yes	0	5	6
22	R:R:V138	R:R:Y134	40.7487	6.31	Yes	Yes	0	6	7
23	R:R:D123	R:R:Y134	36.255	5.75	No	Yes	0	9	7
24	R:R:D123	R:R:T61	36.1503	10.12	No	No	0	9	8
25	R:R:S59	R:R:T61	34.8021	3.2	No	No	0	7	8
26	R:R:H62	R:R:S59	33.1792	13.95	No	No	0	8	7
27	R:R:F333	R:R:H62	19.7766	9.05	Yes	No	4	8	8
28	R:R:F333	R:R:P327	12.1068	4.33	Yes	No	0	8	7
29	R:R:P327	R:R:V47	10.3573	3.53	No	No	0	7	9
30	R:R:F193	R:R:F289	45.5259	18.22	Yes	Yes	0	8	7
31	R:R:F193	R:R:F281	41.7259	4.29	Yes	Yes	0	8	9
32	R:R:C110	R:R:L75	27.8566	3.17	No	Yes	0	6	8
33	R:R:L75	R:R:Y316	16.823	7.03	Yes	Yes	1	8	7
34	R:R:H62	R:R:L57	11.7491	9	No	Yes	4	8	8
35	R:R:V138	R:R:V60	26.7222	4.81	Yes	Yes	0	6	7
36	R:R:V60	R:R:Y64	18.3282	5.05	Yes	Yes	0	7	8
37	R:R:I119	R:R:Y64	15.8588	6.04	No	Yes	0	7	8
38	L:L:?1	R:R:V107	25.9718	12.44	Yes	No	0	0	6
39	R:R:S158	R:R:V107	24.026	3.23	Yes	No	0	8	6
40	R:R:L108	R:R:S158	14.166	6.01	No	Yes	0	6	8
41	R:R:L108	R:R:W151	12.1679	4.56	No	Yes	0	6	9
42	R:R:F281	R:R:L117	16.6049	3.65	Yes	No	0	9	8
43	R:R:V79	R:R:W102	12.1417	6.13	Yes	Yes	0	8	5
44	R:R:W102	R:R:W92	13.9043	11.25	Yes	Yes	0	5	8
45	R:R:G30	R:R:L33	23.5461	1.71	No	Yes	0	6	7
46	R:R:G30	R:R:V88	21.1858	1.84	No	No	0	6	5
47	R:R:L89	R:R:V88	16.8535	1.49	Yes	No	0	5	5
48	L:L:?1	R:R:S188	38.5149	2.79	Yes	No	0	0	7
49	R:R:S188	R:R:Y184	36.796	2.54	No	Yes	0	7	8
50	R:R:N179	R:R:Y184	17.3902	4.65	No	Yes	7	5	8
51	R:R:N179	R:R:R166	15.8239	13.26	No	No	0	5	5
52	R:R:A169	R:R:R166	13.8345	2.77	No	No	0	3	5
53	R:R:A169	R:R:P170	12.1679	1.87	No	No	0	3	4
54	R:R:I119	R:R:V150	12.3947	3.07	No	No	0	7	6
55	R:R:M115	R:R:V150	10.6496	7.61	No	No	0	6	6
56	R:R:S121	R:R:Y204	27.2458	10.17	No	Yes	0	9	9
57	R:R:V277	R:R:Y204	17.7305	5.05	No	Yes	0	8	9
58	R:R:L274	R:R:V277	14.454	2.98	No	No	0	9	8
59	R:R:W165	R:R:Y184	14.166	5.79	No	Yes	0	6	8
60	R:R:F193	R:R:L286	26.8226	3.65	Yes	Yes	0	8	7
61	R:R:L286	R:R:P287	23.7075	3.28	Yes	No	0	7	9
62	R:R:P287	R:R:V311	20.6579	3.53	No	No	0	9	5
63	R:R:V291	R:R:V311	19.5759	4.81	No	No	0	5	5
64	R:R:P303	R:R:V291	18.4852	1.77	Yes	No	0	4	5
65	R:R:F301	R:R:P303	11.9061	11.56	No	Yes	0	3	4

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:D106	12.59	1	Yes	No	0	7	0	1
L:L:?1	R:R:V107	12.44	1	Yes	No	0	6	0	1
L:L:?1	R:R:C110	5.89	1	Yes	No	0	6	0	1
L:L:?1	R:R:I178	5.3	1	Yes	No	0	6	0	1
L:L:?1	R:R:F288	21.47	1	Yes	No	0	7	0	1
L:L:?1	R:R:F289	5.65	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:F312	11.3	1	Yes	No	0	6	0	1
L:L:?1	R:R:Y316	4.35	1	Yes	Yes	0	7	0	1
R:R:L75	R:R:V79	4.47	1	Yes	Yes	8	8	2	2
R:R:C110	R:R:L75	3.17	0	No	Yes	6	8	1	2
R:R:L75	R:R:Y316	7.03	1	Yes	Yes	8	7	2	1
R:R:D106	R:R:V79	7.3	1	No	Yes	7	8	1	2
R:R:V79	R:R:Y316	3.79	1	Yes	Yes	8	7	2	1
R:R:L80	R:R:W313	3.42	1	Yes	Yes	8	6	2	2
R:R:L80	R:R:Y316	11.72	1	Yes	Yes	8	7	2	1
R:R:S83	R:R:W313	4.94	1	No	Yes	7	6	2	2
R:R:S83	R:R:Y316	5.09	1	No	Yes	7	7	2	1
R:R:D106	R:R:Y316	11.49	1	No	Yes	7	7	1	1
R:R:S158	R:R:V107	3.23	0	Yes	No	8	6	2	1
R:R:C110	R:R:W285	7.84	0	No	Yes	6	8	1	2
R:R:E180	R:R:I178	4.1	0	No	No	5	6	2	1
R:R:F312	R:R:I178	3.77	1	No	No	6	6	1	1
R:R:E180	R:R:M292	5.41	0	No	Yes	5	7	2	2
R:R:F193	R:R:F289	18.22	0	Yes	Yes	8	7	2	1
R:R:F289	R:R:W285	4.01	1	Yes	Yes	7	8	1	2
R:R:F288	R:R:F289	7.5	1	No	Yes	7	7	1	1
R:R:F288	R:R:M292	7.46	1	No	Yes	7	7	1	2
R:R:F312	R:R:Y316	8.25	1	No	Yes	6	7	1	1
R:R:W313	R:R:Y316	5.79	1	Yes	Yes	6	7	2	1
L:L:?1	R:R:S188	2.79	1	Yes	No	0	7	0	1
R:R:A189	R:R:F289	2.77	0	No	Yes	7	7	2	1
R:R:S188	R:R:Y184	2.54	0	No	Yes	7	8	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7YMH_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.07
Number of Linked Nodes	251
Number of Links	272
Number of Hubs	37
Number of Links mediated by Hubs	149
Number of Communities	8
Number of Nodes involved in Communities	43
Number of Links involved in Communities	54

Path Summary
Number Of Nodes in MetaPath	66
Number Of Links MetaPath	65
Number of Shortest Paths	47405
Length Of Smallest Path	3
Average Path Length	13.3773
Length of Longest Path	31
Minimum Path Strength	1.19
Average Path Strength	6.01804
Maximum Path Strength	17.03
Minimum Path Correlation	0.7
Average Path Correlation	0.912674
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.16667
Average % Of Corr. Nodes	43.1131
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	47.5883
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• hydrolase activity, acting on glycosyl bonds • peptidoglycan muralytic activity • hydrolase activity, hydrolyzing O-glycosyl compounds • lysozyme activity • hydrolase activity • catalytic activity • protein heterodimerization activity • protein binding • binding • protein dimerization activity • alpha1-adrenergic receptor activity • alpha-adrenergic receptor activity • G protein-coupled amine receptor activity • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • adrenergic receptor activity • biological process involved in interspecies interaction between organisms • response to stimulus • response to other organism • defense response • response to external stimulus • response to biotic stimulus • defense response to bacterium • defense response to other organism • response to stress • response to bacterium • response to external biotic stimulus • carbohydrate derivative catabolic process • catabolic process • peptidoglycan catabolic process
Gene Ontology	Biological Process	• biological process involved in interspecies interaction between organisms • response to stimulus • response to other organism • defense response • response to external stimulus • response to biotic stimulus • defense response to bacterium • defense response to other organism • response to stress • response to bacterium • response to external biotic stimulus • carbohydrate derivative catabolic process • catabolic process • peptidoglycan catabolic process • glycosaminoglycan metabolic process • carbohydrate derivative metabolic process • aminoglycan catabolic process • macromolecule catabolic process • glycosaminoglycan catabolic process • aminoglycan metabolic process • peptidoglycan metabolic process • metabolic process • cellular process • macromolecule metabolic process • symbiont-mediated cytolysis of host cell • viral life cycle • disruption of cell in another organism • cytolysis • biological process involved in interaction with host • biological process involved in symbiotic interaction • viral release from host cell by cytolysis • exit from host cell • viral process • cytolysis in another organism • viral release from host cell • disruption of anatomical structure in another organism • symbiont-mediated killing of host cell • killing of cells of another organism • cell killing • cell wall organization or biogenesis • cell wall macromolecule catabolic process • cell wall macromolecule metabolic process • response to chemical • response to xenobiotic stimulus • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • regulation of biological process • signaling • cell-cell signaling • neuron-glial cell signaling • cell communication • cellular response to stimulus • positive regulation of cell communication • regulation of cellular process • positive regulation of signal transduction • positive regulation of biological process • regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • intracellular signaling cassette • signal transduction • positive regulation of cellular process • regulation of signaling • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • regulation of tube diameter • multicellular organismal process • system process • regulation of tube size • regulation of system process • positive regulation of vasoconstriction • circulatory system process • regulation of blood circulation • vascular process in circulatory system • regulation of vasoconstriction • positive regulation of multicellular organismal process • regulation of multicellular organismal process • blood vessel diameter maintenance • vasoconstriction • blood circulation • regulation of anatomical structure size • heart process • negative regulation of heart rate • regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback • regulation of heart contraction • negative regulation of biological process • negative regulation of blood pressure • negative regulation of systemic arterial blood pressure • nervous system process involved in regulation of systemic arterial blood pressure • regulation of heart rate • nervous system process • regulation of blood pressure • regulation of systemic arterial blood pressure by baroreceptor feedback • negative regulation of blood circulation • negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure • baroreceptor response to increased systemic arterial blood pressure • negative regulation of heart contraction • regulation of systemic arterial blood pressure • heart contraction • negative regulation of multicellular organismal process • phospholipase C-activating G protein-coupled receptor signaling pathway • phospholipase C-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • G protein-coupled receptor signaling pathway • regulation of systemic arterial blood pressure mediated by a chemical signal • positive regulation of blood pressure • positive regulation of blood circulation • regulation of systemic arterial blood pressure by norepinephrine-epinephrine • positive regulation of blood pressure by epinephrine-norepinephrine • positive regulation of heart rate • positive regulation of heart rate by epinephrine-norepinephrine • positive regulation of heart contraction • reflex • pilomotor reflex • modulation of chemical synaptic transmission • positive regulation of synaptic transmission, GABAergic • synaptic signaling • trans-synaptic signaling • synaptic transmission, GABAergic • positive regulation of synaptic transmission • chemical synaptic transmission • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • regulation of synaptic transmission, GABAergic • smooth muscle contraction • muscle contraction • muscle system process • apoptotic process • cell death • programmed cell death • norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure • regulation of action potential • positive regulation of action potential • action potential • regulation of membrane potential • adenylate cyclase-activating adrenergic receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • negative regulation of cell population proliferation • cell population proliferation • regulation of cell population proliferation • negative regulation of cellular process • muscle hypertrophy • regulation of muscle adaptation • positive regulation of cardiac muscle hypertrophy • striated muscle hypertrophy • regulation of muscle system process • regulation of cardiac muscle hypertrophy • regulation of muscle hypertrophy • muscle adaptation • positive regulation of muscle hypertrophy • cardiac muscle hypertrophy • negative regulation of catabolic process • negative regulation of metabolic process • autophagy • regulation of catabolic process • regulation of autophagy • negative regulation of autophagy • process utilizing autophagic mechanism • regulation of metabolic process • positive regulation of smooth muscle contraction • regulation of muscle contraction • regulation of smooth muscle contraction • positive regulation of muscle contraction • cellular developmental process • cardiac muscle cell development • developmental growth • cell development • organ growth • muscle cell differentiation • cell growth • striated muscle tissue development • muscle structure development • multicellular organism development • striated muscle cell development • muscle cell development • cell differentiation • anatomical structure development • cardiac cell development • muscle tissue development • cardiac muscle tissue growth • system development • developmental process • heart development • heart growth • developmental cell growth • cardiac muscle tissue development • physiological muscle hypertrophy • growth • animal organ development • cardiac muscle cell differentiation • tissue development • cardiocyte differentiation • circulatory system development • cell growth involved in cardiac muscle cell development • physiological cardiac muscle hypertrophy • striated muscle cell differentiation • regulation of the force of heart contraction by chemical signal • regulation of the force of heart contraction • positive regulation of the force of heart contraction by chemical signal • positive regulation of the force of heart contraction by epinephrine-norepinephrine • adult heart development • response to hormone • response to endogenous stimulus • positive regulation of cardiac muscle contraction • cardiac muscle contraction • striated muscle contraction • positive regulation of striated muscle contraction • regulation of cardiac muscle contraction • regulation of striated muscle contraction • host cellular component • host intracellular part • cellular anatomical structure • host cell cytoplasm • host cell part • host intracellular region • membrane-bounded organelle • intracellular anatomical structure • nuclear membrane • membrane • nucleus • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle
Gene Ontology	Cellular Component	• host cellular component • host intracellular part • cellular anatomical structure • host cell cytoplasm • host cell part • host intracellular region • membrane-bounded organelle • intracellular anatomical structure • nuclear membrane • membrane • nucleus • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • organelle envelope • organelle • nuclear envelope • organelle membrane • cytoplasm • cytosol • membrane microdomain • cell periphery • membrane raft • plasma membrane raft • plasma membrane • plasma membrane region • caveola • membrane-enclosed lumen • intracellular organelle lumen • nucleoplasm • organelle lumen • nuclear lumen
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	E5E
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	E5E
Name	Noradrenaline
Synonyms
Identifier
Formula	C8 H12 N O3
Molecular Weight	170.186
SMILES
PubChem	6921840
Formal Charge	1
Total Atoms	24
Total Chiral Atoms	1
Total Bonds	24
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P35348
Sequence	>7YMH_nogp_Chain_R K A I L L G V I L G G L I L F G V L G N I L V I L S V A C H R H L H S V T H Y Y I V N L A V A D L L L T S T V L P F S A I F E V L G Y W A F G R V F C N I W A A V D V L C C T A S I M G L C I I S I D R Y I G V S Y P L R Y P T I V T Q R R G L M A L L C V W A L S L V I S I G P L F G W R Q P A P E D E T I C Q I N E E P G Y V L F S A L G S F Y L P L A I I L V M Y C R V Y V V A K R E L K F S R E K K A A K T L G I V V G C F V L C W L P F F L V M P I G S F F P D F K P S E T V F K I V F W L G Y L N S C I N P I I Y P C S S Q E F K K A F Q N V L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8HN1	A	Amine	Adrenergic	Alpha1A	Homo sapiens	Toxin AdTx1	-	-	2.9	2023-12-20	To be published
	8THL	A	Amine	Adrenergic	Alpha1A	Homo sapiens	Epinephrine	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.1	2023-08-16	10.1038/s41467-023-40524-2
	8THL (No Gprot)	A	Amine	Adrenergic	Alpha1A	Homo sapiens	Epinephrine	-		3.1	2023-08-16	10.1038/s41467-023-40524-2
	8THK	A	Amine	Adrenergic	Alpha1A	Homo sapiens	A61603	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	2.6	2023-08-16	10.1038/s41467-023-40524-2
	8THK (No Gprot)	A	Amine	Adrenergic	Alpha1A	Homo sapiens	A61603	-		2.6	2023-08-16	10.1038/s41467-023-40524-2
	7YMJ	A	Amine	Adrenergic	Alpha1A	Homo sapiens	Tamsulosin	-	-	3.35	2023-07-05	10.1038/s41467-023-39310-x
	7YMH	A	Amine	Adrenergic	Alpha1A	Homo sapiens	Norepinephrine	-	chim(Gs-CtGq)	3.52	2023-07-05	10.1038/s41467-023-39310-x
	7YMH (No Gprot)	A	Amine	Adrenergic	Alpha1A	Homo sapiens	Norepinephrine	-		3.52	2023-07-05	10.1038/s41467-023-39310-x
	7YM8	A	Amine	Adrenergic	Alpha1A	Homo sapiens	Oxymetazoline	-	chim(Gs-CtGq)	2.92	2023-07-05	10.1038/s41467-023-39310-x
	7YM8 (No Gprot)	A	Amine	Adrenergic	Alpha1A	Homo sapiens	Oxymetazoline	-		2.92	2023-07-05	10.1038/s41467-023-39310-x

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