psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D106	16.61	Yes	No	1	0	7
2	L:L:?1	R:R:V107	9.82	Yes	No	0	0	6
3	L:L:?1	R:R:C110	8.97	Yes	No	1	0	6
4	L:L:?1	R:R:S188	7.07	Yes	No	0	0	7
5	L:L:?1	R:R:W285	5.36	Yes	Yes	1	0	8
6	L:L:?1	R:R:F288	11.47	Yes	No	1	0	7
7	L:L:?1	R:R:F289	10.32	Yes	Yes	1	0	7
8	L:L:?1	R:R:M292	6.66	Yes	No	0	0	7
9	L:L:?1	R:R:F312	12.61	Yes	Yes	1	0	6
10	L:L:?1	R:R:Y316	8.83	Yes	Yes	1	0	7
11	R:R:A84	R:R:L33	4.73	No	No	0	6	7
12	R:R:G34	R:R:I37	7.05	No	No	0	3	5
13	R:R:F39	R:R:G35	4.52	No	No	0	5	5
14	R:R:L317	R:R:L36	5.54	No	No	0	5	7
15	R:R:I37	R:R:L80	12.85	No	No	0	5	8
16	R:R:T76	R:R:V41	7.93	No	No	0	7	6
17	R:R:G43	R:R:L42	5.13	No	No	0	9	4
18	R:R:L42	R:R:L46	5.54	No	No	0	4	7
19	R:R:I48	R:R:N44	7.08	No	No	0	7	9
20	R:R:A69	R:R:N44	4.69	No	No	0	9	9
21	R:R:L73	R:R:N44	9.61	No	No	0	7	9
22	R:R:I45	R:R:L49	7.14	No	No	0	4	4
23	R:R:I48	R:R:V66	4.61	No	No	0	7	6
24	R:R:I48	R:R:V70	4.61	No	No	0	7	6
25	R:R:L57	R:R:V51	13.41	No	No	0	8	8
26	R:R:V51	R:R:V66	11.22	No	No	0	8	6
27	R:R:H54	R:R:H56	4.78	No	No	0	6	6
28	R:R:H54	R:R:L57	9	No	No	0	6	8
29	R:R:H58	R:R:R55	5.64	No	No	0	8	7
30	R:R:H56	R:R:H62	5.97	No	No	0	6	8
31	R:R:H62	R:R:L57	18	No	No	0	8	8
32	R:R:H62	R:R:S59	8.37	No	No	0	8	7
33	R:R:V60	R:R:Y64	6.31	No	Yes	0	7	8
34	R:R:V138	R:R:V60	4.81	No	No	0	6	7
35	R:R:D123	R:R:T61	4.34	No	No	0	9	8
36	R:R:I119	R:R:Y64	12.09	No	Yes	0	7	8
37	R:R:D123	R:R:Y64	6.9	No	Yes	0	9	8
38	R:R:L147	R:R:N67	13.73	No	No	4	8	9
39	R:R:N67	R:R:W151	11.3	No	Yes	4	9	9
40	R:R:D72	R:R:L68	5.43	Yes	No	2	9	9
41	R:R:L117	R:R:L68	5.54	No	No	2	8	9
42	R:R:L68	R:R:N322	5.49	No	Yes	2	9	9
43	R:R:D72	R:R:S113	5.89	Yes	No	0	9	9
44	R:R:D72	R:R:S319	7.36	Yes	No	0	9	9
45	R:R:D72	R:R:N322	8.08	Yes	Yes	2	9	9
46	R:R:L73	R:R:T76	4.42	No	No	0	7	7
47	R:R:L73	R:R:S77	4.5	No	No	0	7	5
48	R:R:C109	R:R:L74	4.76	No	No	0	6	6
49	R:R:C109	R:R:L75	6.35	No	No	0	6	8
50	R:R:L75	R:R:S319	7.51	No	No	0	8	9
51	R:R:L80	R:R:T76	5.9	No	No	0	8	7
52	R:R:T78	R:R:V105	4.76	No	No	0	6	5
53	R:R:V79	R:R:W102	6.13	No	No	0	8	5
54	R:R:D106	R:R:V79	13.15	No	No	0	7	8
55	R:R:L80	R:R:Y316	8.21	No	Yes	0	8	7
56	R:R:F82	R:R:F94	5.36	No	Yes	0	5	5
57	R:R:F82	R:R:W102	5.01	No	No	0	5	5
58	R:R:S83	R:R:W313	6.18	No	Yes	1	7	6
59	R:R:S83	R:R:Y316	7.63	No	Yes	1	7	7
60	R:R:I85	R:R:L89	4.28	No	No	0	5	5
61	R:R:F86	R:R:W92	13.03	No	Yes	0	4	8
62	R:R:E87	R:R:W313	8.72	No	Yes	0	5	6
63	R:R:C99	R:R:W92	19.59	No	Yes	5	9	8
64	R:R:C176	R:R:W92	5.22	No	Yes	5	9	8
65	R:R:F94	R:R:F98	4.29	Yes	No	0	5	5
66	R:R:C176	R:R:C99	7.28	No	No	5	9	9
67	R:R:I101	R:R:N100	4.25	No	No	0	5	6
68	R:R:L162	R:R:N100	6.87	No	No	0	5	6
69	R:R:N100	R:R:R166	4.82	No	Yes	0	6	5
70	R:R:D106	R:R:Y316	10.34	No	Yes	1	7	7
71	R:R:L108	R:R:S158	9.01	No	No	0	6	8
72	R:R:C110	R:R:W285	5.22	No	Yes	1	6	8
73	R:R:S154	R:R:T111	6.4	No	No	0	8	7
74	R:R:S192	R:R:T111	9.59	No	No	0	6	7
75	R:R:A112	R:R:W151	5.19	No	Yes	0	8	9
76	R:R:I114	R:R:W285	15.27	No	Yes	0	8	8
77	R:R:M115	R:R:V150	6.09	No	No	0	6	6
78	R:R:L117	R:R:N322	9.61	No	Yes	2	8	9
79	R:R:L117	R:R:Y326	10.55	No	Yes	2	8	9
80	R:R:C118	R:R:I199	6.55	No	No	0	6	6
81	R:R:I120	R:R:R124	6.26	No	No	2	9	9
82	R:R:I120	R:R:Y326	6.04	No	Yes	2	9	9
83	R:R:M203	R:R:S121	4.6	No	No	0	6	9
84	R:R:S121	R:R:Y204	15.26	No	Yes	0	9	9
85	R:R:D123	R:R:Y134	9.2	No	Yes	0	9	7
86	R:R:R124	R:R:Y204	8.23	No	Yes	0	9	9
87	R:R:R124	R:R:Y326	6.17	No	Yes	2	9	9
88	R:R:S129	R:R:Y125	13.99	No	Yes	0	7	8
89	R:R:M203	R:R:Y125	13.17	No	Yes	0	6	8
90	R:R:R206	R:R:Y125	11.32	No	Yes	0	6	8
91	R:R:I126	R:R:Y130	4.84	No	Yes	0	5	6
92	R:R:I126	R:R:I137	4.42	No	No	0	5	5
93	R:R:I126	R:R:V138	4.61	No	No	0	5	6
94	R:R:G127	R:R:Y134	5.79	No	Yes	0	8	7
95	R:R:S129	R:R:Y130	6.36	No	Yes	0	7	6
96	R:R:V138	R:R:Y134	11.36	No	Yes	0	6	7
97	R:R:L147	R:R:W151	4.56	No	Yes	4	8	9
98	R:R:F187	R:R:I157	7.54	No	No	0	5	6
99	R:R:P161	R:R:R166	4.32	Yes	Yes	3	7	5
100	R:R:N179	R:R:P161	8.15	No	Yes	3	5	7
101	R:R:P161	R:R:Y184	11.13	Yes	No	3	7	8
102	R:R:Q167	R:R:R166	8.18	No	Yes	0	5	5
103	R:R:N179	R:R:R166	13.26	No	Yes	3	5	5
104	R:R:I175	R:R:T174	4.56	No	No	0	5	1
105	R:R:E180	R:R:Q177	5.1	No	No	0	5	5
106	R:R:E180	R:R:I178	5.47	No	No	0	5	6
107	R:R:F312	R:R:I178	5.02	Yes	No	0	6	6
108	R:R:N179	R:R:Y184	17.44	No	No	3	5	8
109	R:R:S188	R:R:Y184	12.72	No	No	0	7	8
110	R:R:M292	R:R:V185	6.09	No	No	0	7	6
111	R:R:S296	R:R:V185	9.7	No	No	0	5	6
112	R:R:G191	R:R:L190	5.13	No	No	0	5	4
113	R:R:F289	R:R:S192	5.28	Yes	No	0	7	6
114	R:R:F193	R:R:Y194	7.22	Yes	No	0	8	6
115	R:R:F193	R:R:L197	12.18	Yes	No	0	8	6
116	R:R:F193	R:R:F281	4.29	Yes	No	1	8	9
117	R:R:F193	R:R:W285	5.01	Yes	Yes	1	8	8
118	R:R:F193	R:R:L286	7.31	Yes	Yes	0	8	7
119	R:R:F193	R:R:F289	18.22	Yes	Yes	1	8	7
120	R:R:L195	R:R:P196	6.57	No	No	0	5	9
121	R:R:L197	R:R:L201	5.54	No	No	0	6	5
122	R:R:F281	R:R:I200	5.02	No	No	0	9	8
123	R:R:L274	R:R:Y204	12.89	No	Yes	0	9	9
124	R:R:V278	R:R:Y204	5.05	No	Yes	0	8	9
125	R:R:A271	R:R:Y208	5.34	No	No	0	7	5
126	R:R:E214	R:R:R213	11.63	No	No	0	7	5
127	R:R:K269	R:R:K272	5.75	No	No	0	8	7
128	R:R:K269	R:R:T273	4.5	No	No	0	8	9
129	R:R:C280	R:R:I321	4.91	No	No	0	7	6
130	R:R:F281	R:R:W285	5.01	No	Yes	1	9	8
131	R:R:F289	R:R:W285	5.01	Yes	Yes	1	7	8
132	R:R:G315	R:R:W285	8.44	No	Yes	0	7	8
133	R:R:N318	R:R:W285	11.3	Yes	Yes	0	9	8
134	R:R:L286	R:R:L290	8.3	Yes	No	0	7	6
135	R:R:F288	R:R:V311	10.49	No	No	0	7	5
136	R:R:F288	R:R:F312	16.08	No	Yes	1	7	6
137	R:R:V291	R:R:V311	8.02	No	No	0	5	5
138	R:R:M292	R:R:P293	11.74	No	No	0	7	6
139	R:R:F298	R:R:I294	7.54	No	Yes	0	4	5
140	R:R:F297	R:R:F298	4.29	No	No	0	5	4
141	R:R:I310	R:R:K309	5.82	No	No	0	5	5
142	R:R:K309	R:R:W313	5.8	No	Yes	0	5	6
143	R:R:F312	R:R:Y316	5.16	Yes	Yes	1	6	7
144	R:R:W313	R:R:Y316	8.68	Yes	Yes	1	6	7
145	R:R:N318	R:R:S319	4.47	Yes	No	0	9	9
146	R:R:N318	R:R:N322	12.26	Yes	Yes	0	9	9
147	R:R:I321	R:R:I325	5.89	No	No	0	6	8
148	R:R:I325	R:R:Y326	4.84	No	Yes	0	8	9
149	R:R:G95	R:R:W92	4.22	No	Yes	0	8	8
150	R:R:P135	R:R:Y134	4.17	No	Yes	0	6	7
151	R:R:G160	R:R:P161	4.06	No	Yes	0	7	7
152	R:R:F94	R:R:W92	4.01	Yes	Yes	0	5	8
153	R:R:C320	R:R:G40	3.92	No	No	0	6	8
154	R:R:R96	R:R:V97	3.92	No	No	0	5	3
155	R:R:R206	R:R:V202	3.92	No	No	0	6	4
156	R:R:R213	R:R:V210	3.92	No	No	0	5	6
157	R:R:V277	R:R:Y204	3.79	No	Yes	0	8	9
158	R:R:V277	R:R:Y326	3.79	No	Yes	0	8	9
159	R:R:L132	R:R:R133	3.64	No	No	0	7	5
160	R:R:I175	R:R:Y91	3.63	No	No	0	5	4
161	R:R:P323	R:R:V47	3.53	No	No	0	9	9
162	R:R:P303	R:R:V291	3.53	Yes	No	0	4	5
163	R:R:P303	R:R:V307	3.53	Yes	No	0	4	5
164	R:R:L274	R:R:Y208	3.52	No	No	0	9	5
165	R:R:E173	R:R:R96	3.49	No	No	0	4	5
166	R:R:G34	R:R:L33	3.42	No	No	0	3	7
167	R:R:A112	R:R:S154	3.42	No	No	0	8	8
168	R:R:G183	R:R:L186	3.42	No	No	0	5	6
169	R:R:I37	R:R:P81	3.39	No	No	0	5	9
170	R:R:A69	R:R:V47	3.39	No	No	0	9	9
171	R:R:I114	R:R:P196	3.39	No	No	0	8	9
172	R:R:I294	R:R:P303	3.39	Yes	Yes	0	5	4
173	R:R:Q140	R:R:Y63	3.38	Yes	No	0	4	5
174	R:R:M115	R:R:P196	3.35	No	No	0	6	9
175	R:R:K302	R:R:P303	3.35	No	Yes	0	3	4
176	R:R:L286	R:R:P287	3.28	Yes	No	0	7	9
177	R:R:L314	R:R:P287	3.28	No	No	0	7	9
178	R:R:C118	R:R:I122	3.27	No	No	0	6	6
179	R:R:C118	R:R:I200	3.27	No	No	0	6	8
180	R:R:A146	R:R:I119	3.25	No	No	0	6	7
181	R:R:S158	R:R:V107	3.23	No	No	0	8	6
182	R:R:F308	R:R:F312	3.22	No	Yes	0	4	6
183	R:R:V128	R:R:V210	3.21	No	No	0	8	6
184	R:R:T78	R:R:V79	3.17	No	No	0	6	8
185	R:R:C149	R:R:L153	3.17	No	No	0	2	5
186	R:R:P168	R:R:Q167	3.16	No	No	0	4	5
187	R:R:A104	R:R:L162	3.15	No	No	0	6	5
188	R:R:C284	R:R:N318	3.15	No	Yes	0	8	9
189	R:R:E181	R:R:P182	3.14	No	No	0	6	4
190	R:R:I157	R:R:T111	3.04	No	No	0	6	7
191	R:R:L286	R:R:V282	2.98	Yes	No	0	7	5
192	R:R:G143	R:R:Y64	2.9	No	Yes	0	7	8
193	R:R:F297	R:R:P182	2.89	No	No	0	5	4
194	R:R:I45	R:R:L46	2.85	No	No	0	4	7
195	R:R:G160	R:R:W165	2.81	No	No	0	7	6
196	R:R:A169	R:R:R96	2.77	No	No	0	3	5
197	R:R:A189	R:R:F289	2.77	No	Yes	0	7	7
198	R:R:L314	R:R:L317	2.77	No	No	0	7	5
199	R:R:L144	R:R:Q140	2.66	No	Yes	0	5	4
200	R:R:A71	R:R:W151	2.59	No	Yes	0	8	9
201	R:R:R133	R:R:T136	2.59	No	No	0	5	4
202	R:R:V207	R:R:Y125	2.52	No	Yes	0	9	8
203	R:R:F163	R:R:I159	2.51	No	No	0	4	4
204	R:R:F301	R:R:I294	2.51	No	Yes	0	3	5
205	R:R:H58	R:R:Q140	2.47	No	Yes	0	8	4
206	R:R:I65	R:R:Y326	2.42	No	Yes	0	7	9
207	R:R:G34	R:R:G35	2.11	No	No	0	3	5
208	R:R:R133	R:R:Y130	2.06	No	Yes	0	5	6
209	R:R:G183	R:R:P182	2.03	No	No	0	5	4
210	R:R:A169	R:R:P170	1.87	No	No	0	3	4
211	R:R:G279	R:R:V278	1.84	No	No	0	5	8
212	R:R:A211	R:R:A270	1.79	No	No	0	8	8
213	R:R:G116	R:R:I119	1.76	No	No	0	7	7
214	R:R:G191	R:R:I157	1.76	No	No	0	5	6
215	R:R:G295	R:R:I294	1.76	No	Yes	0	4	5
216	R:R:G35	R:R:L38	1.71	No	No	0	5	4
217	R:R:G275	R:R:L274	1.71	No	No	0	6	9
218	R:R:S304	R:R:V307	1.62	No	No	0	5	5
219	R:R:S304	R:R:T306	1.6	No	No	0	5	1
220	R:R:C284	R:R:L283	1.59	No	No	0	8	5
221	R:R:I276	R:R:V277	1.54	No	No	0	7	8
222	R:R:F39	R:R:G40	1.51	No	No	0	5	8
223	R:R:F163	R:R:G160	1.51	No	No	0	4	7
224	R:R:L33	R:R:V88	1.49	No	No	0	7	5
225	R:R:L155	R:R:V156	1.49	No	No	0	4	4
226	R:R:D172	R:R:T174	1.45	No	No	0	3	1
227	R:R:F298	R:R:P299	1.44	No	No	0	4	2
228	R:R:E305	R:R:S304	1.44	No	No	0	2	5
229	R:R:Q140	R:R:V60	1.43	Yes	No	0	4	7
230	R:R:I159	R:R:L155	1.43	No	No	0	4	4
231	R:R:L153	R:R:M115	1.41	No	No	0	5	6
232	R:R:A93	R:R:F94	1.39	No	Yes	0	3	5
233	R:R:P131	R:R:Y130	1.39	No	Yes	0	8	6
234	R:R:P327	R:R:Y326	1.39	No	Yes	0	7	9
235	R:R:A169	R:R:R166	1.38	No	Yes	0	3	5
236	R:R:D172	R:R:E171	1.3	No	No	0	3	3
237	R:R:R142	R:R:T139	1.29	No	No	0	6	7
238	R:R:K212	R:R:Y208	1.19	No	No	0	5	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	9.772	10	1	0
2	R:R:Y64	7.05	4	0	8
3	R:R:D72	6.69	4	2	9
4	R:R:W92	9.214	5	5	8
5	R:R:F94	3.7625	4	0	5
6	R:R:Y125	10.25	4	0	8
7	R:R:Y130	3.6625	4	0	6
8	R:R:Y134	7.63	4	0	7
9	R:R:Q140	2.485	4	0	4
10	R:R:W151	5.91	4	4	9
11	R:R:P161	6.915	4	3	7
12	R:R:R166	6.392	5	3	5
13	R:R:F193	9.03833	6	1	8
14	R:R:Y204	9.044	5	0	9
15	R:R:W285	7.5775	8	1	8
16	R:R:L286	5.4675	4	0	7
17	R:R:F289	8.32	5	1	7
18	R:R:I294	3.8	4	0	5
19	R:R:P303	3.45	4	0	4
20	R:R:F312	8.418	5	1	6
21	R:R:W313	7.345	4	1	6
22	R:R:Y316	8.14167	6	1	7
23	R:R:N318	7.795	4	0	9
24	R:R:N322	8.86	4	2	9
25	R:R:Y326	5.02857	7	2	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y316	48.7328	8.83	Yes	Yes	1	0	7
2	R:R:L80	R:R:Y316	49.4257	8.21	No	Yes	0	8	7
3	R:R:I37	R:R:L80	19.3134	12.85	No	No	0	5	8
4	R:R:G34	R:R:I37	15.8742	7.05	No	No	0	3	5
5	L:L:?1	R:R:W285	92.2618	5.36	Yes	Yes	1	0	8
6	R:R:F193	R:R:W285	16.086	5.01	Yes	Yes	1	8	8
7	R:R:F193	R:R:L286	16.4774	7.31	Yes	Yes	0	8	7
8	L:L:?1	R:R:F289	18.691	10.32	Yes	Yes	1	0	7
9	R:R:L80	R:R:T76	31.1774	5.9	No	No	0	8	7
10	R:R:L73	R:R:T76	27.9179	4.42	No	No	0	7	7
11	R:R:L73	R:R:N44	24.607	9.61	No	No	0	7	9
12	R:R:I48	R:R:N44	17.8312	7.08	No	No	0	7	9
13	R:R:I48	R:R:V66	14.3664	4.61	No	No	0	7	6
14	R:R:V51	R:R:V66	12.6147	11.22	No	No	0	8	6
15	R:R:L57	R:R:V51	10.8502	13.41	No	No	0	8	8
16	R:R:N318	R:R:W285	100	11.3	Yes	Yes	0	9	8
17	R:R:N318	R:R:N322	95.0914	12.26	Yes	Yes	0	9	9
18	R:R:L117	R:R:N322	94.9824	9.61	No	Yes	2	8	9
19	R:R:L117	R:R:Y326	98.2676	10.55	No	Yes	2	8	9
20	R:R:R124	R:R:Y326	46.0956	6.17	No	Yes	2	9	9
21	R:R:R124	R:R:Y204	45.4989	8.23	No	Yes	0	9	9
22	R:R:S121	R:R:Y204	73.6927	15.26	No	Yes	0	9	9
23	R:R:M203	R:R:S121	71.5945	4.6	No	No	0	6	9
24	R:R:M203	R:R:Y125	69.2782	13.17	No	Yes	0	6	8
25	R:R:S129	R:R:Y125	60.1797	13.99	No	Yes	0	7	8
26	R:R:S129	R:R:Y130	57.8569	6.36	No	Yes	0	7	6
27	R:R:I126	R:R:Y130	46.0507	4.84	No	Yes	0	5	6
28	R:R:I126	R:R:V138	41.1999	4.61	No	No	0	5	6
29	R:R:V138	R:R:V60	26.7372	4.81	No	No	0	6	7
30	R:R:Q140	R:R:V60	12.358	1.43	Yes	No	0	4	7
31	R:R:V277	R:R:Y326	47.1864	3.79	No	Yes	0	8	9
32	R:R:V277	R:R:Y204	45.3705	3.79	No	Yes	0	8	9
33	R:R:V60	R:R:Y64	12.5377	6.31	No	Yes	0	7	8
34	R:R:V138	R:R:Y134	12.4607	11.36	No	Yes	0	6	7
35	R:R:F289	R:R:S192	19.3969	5.28	Yes	No	0	7	6
36	R:R:S192	R:R:T111	17.8505	9.59	No	No	0	6	7
37	L:L:?1	R:R:D106	19.4546	16.61	Yes	No	1	0	7
38	R:R:D106	R:R:V79	21.495	13.15	No	No	0	7	8
39	R:R:V79	R:R:W102	16.657	6.13	No	No	0	8	5
40	R:R:F82	R:R:W102	15.2839	5.01	No	No	0	5	5
41	R:R:F82	R:R:F94	13.6413	5.36	No	Yes	0	5	5
42	L:L:?1	R:R:S188	50.3112	7.07	Yes	No	0	0	7
43	R:R:S188	R:R:Y184	49.0151	12.72	No	No	0	7	8
44	R:R:P161	R:R:Y184	28.5082	11.13	Yes	No	3	7	8
45	R:R:P161	R:R:R166	18.4023	4.32	Yes	Yes	3	7	5
46	R:R:N100	R:R:R166	12.1527	4.82	No	Yes	0	6	5
47	R:R:N179	R:R:Y184	19.1915	17.44	No	No	3	5	8
48	R:R:N179	R:R:R166	17.9467	13.26	No	Yes	3	5	5
49	R:R:I114	R:R:W285	11.2672	15.27	No	Yes	0	8	8
50	R:R:L274	R:R:Y204	12.8008	12.89	No	Yes	0	9	9
51	L:L:?1	R:R:F288	29.862	11.47	Yes	No	1	0	7
52	R:R:F288	R:R:V311	33.1408	10.49	No	No	0	7	5
53	R:R:V291	R:R:V311	31.4084	8.02	No	No	0	5	5
54	R:R:P303	R:R:V291	29.6631	3.53	Yes	No	0	4	5
55	R:R:I294	R:R:P303	18.922	3.39	Yes	Yes	0	5	4
56	R:R:F298	R:R:I294	13.3782	7.54	No	Yes	0	4	5
57	R:R:A169	R:R:R166	15.3288	1.38	No	Yes	0	3	5
58	R:R:F289	R:R:W285	10.5037	5.01	Yes	Yes	1	7	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:D106	16.61	1	Yes	No	0	7	0	1
L:L:?1	R:R:V107	9.82	1	Yes	No	0	6	0	1
L:L:?1	R:R:C110	8.97	1	Yes	No	0	6	0	1
L:L:?1	R:R:S188	7.07	1	Yes	No	0	7	0	1
L:L:?1	R:R:W285	5.36	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:F288	11.47	1	Yes	No	0	7	0	1
L:L:?1	R:R:F289	10.32	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:M292	6.66	1	Yes	No	0	7	0	1
L:L:?1	R:R:F312	12.61	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:Y316	8.83	1	Yes	Yes	0	7	0	1
R:R:D106	R:R:V79	13.15	1	No	No	7	8	1	2
R:R:L80	R:R:Y316	8.21	0	No	Yes	8	7	2	1
R:R:S83	R:R:W313	6.18	1	No	Yes	7	6	2	2
R:R:S83	R:R:Y316	7.63	1	No	Yes	7	7	2	1
R:R:D106	R:R:Y316	10.34	1	No	Yes	7	7	1	1
R:R:C110	R:R:W285	5.22	1	No	Yes	6	8	1	1
R:R:I114	R:R:W285	15.27	0	No	Yes	8	8	2	1
R:R:F312	R:R:I178	5.02	1	Yes	No	6	6	1	2
R:R:S188	R:R:Y184	12.72	0	No	No	7	8	1	2
R:R:M292	R:R:V185	6.09	0	No	No	7	6	1	2
R:R:F289	R:R:S192	5.28	1	Yes	No	7	6	1	2
R:R:F193	R:R:F281	4.29	1	Yes	No	8	9	2	2
R:R:F193	R:R:W285	5.01	1	Yes	Yes	8	8	2	1
R:R:F193	R:R:F289	18.22	1	Yes	Yes	8	7	2	1
R:R:F281	R:R:W285	5.01	1	No	Yes	9	8	2	1
R:R:F289	R:R:W285	5.01	1	Yes	Yes	7	8	1	1
R:R:G315	R:R:W285	8.44	0	No	Yes	7	8	2	1
R:R:N318	R:R:W285	11.3	0	Yes	Yes	9	8	2	1
R:R:F288	R:R:V311	10.49	1	No	No	7	5	1	2
R:R:F288	R:R:F312	16.08	1	No	Yes	7	6	1	1
R:R:M292	R:R:P293	11.74	0	No	No	7	6	1	2
R:R:F312	R:R:Y316	5.16	1	Yes	Yes	6	7	1	1
R:R:W313	R:R:Y316	8.68	1	Yes	Yes	6	7	2	1
R:R:S158	R:R:V107	3.23	0	No	No	8	6	2	1
R:R:F308	R:R:F312	3.22	0	No	Yes	4	6	2	1
R:R:A189	R:R:F289	2.77	0	No	Yes	7	7	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8THL_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	4.24
Number of Linked Nodes	227
Number of Links	238
Number of Hubs	25
Number of Links mediated by Hubs	106
Number of Communities	5
Number of Nodes involved in Communities	29
Number of Links involved in Communities	39

Path Summary
Number Of Nodes in MetaPath	59
Number Of Links MetaPath	58
Number of Shortest Paths	32414
Length Of Smallest Path	3
Average Path Length	13.414
Length of Longest Path	30
Minimum Path Strength	1.375
Average Path Strength	7.87049
Maximum Path Strength	16.31
Minimum Path Correlation	0.7
Average Path Correlation	0.908448
Maximum Path Correlation	0.98
Minimum % Of Corr. Nodes	3.57143
Average % Of Corr. Nodes	43.3825
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	40.0592
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• hydrolase activity, acting on glycosyl bonds • peptidoglycan muralytic activity • hydrolase activity, hydrolyzing O-glycosyl compounds • lysozyme activity • hydrolase activity • catalytic activity • protein heterodimerization activity • protein binding • binding • protein dimerization activity • alpha1-adrenergic receptor activity • alpha-adrenergic receptor activity • G protein-coupled amine receptor activity • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • adrenergic receptor activity • defense response to bacterium • biological process involved in interspecies interaction between organisms • response to stimulus • response to other organism • defense response • response to bacterium • response to stress • response to external stimulus • response to external biotic stimulus • response to biotic stimulus • carbohydrate derivative catabolic process • catabolic process • peptidoglycan catabolic process • glycosaminoglycan metabolic process
Gene Ontology	Biological Process	• defense response to bacterium • biological process involved in interspecies interaction between organisms • response to stimulus • response to other organism • defense response • response to bacterium • response to stress • response to external stimulus • response to external biotic stimulus • response to biotic stimulus • carbohydrate derivative catabolic process • catabolic process • peptidoglycan catabolic process • glycosaminoglycan metabolic process • carbohydrate derivative metabolic process • aminoglycan catabolic process • macromolecule catabolic process • glycosaminoglycan catabolic process • aminoglycan metabolic process • peptidoglycan metabolic process • metabolic process • cellular process • macromolecule metabolic process • symbiont-mediated cytolysis of host cell • viral life cycle • disruption of cell in another organism • cytolysis • biological process involved in interaction with host • biological process involved in symbiotic interaction • viral release from host cell by cytolysis • exit from host cell • viral process • cytolysis in another organism • viral release from host cell • disruption of anatomical structure in another organism • symbiont-mediated killing of host cell • killing of cells of another organism • cell killing • cell wall organization or biogenesis • cell wall macromolecule catabolic process • cell wall macromolecule metabolic process • response to chemical • response to xenobiotic stimulus • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • regulation of biological process • signaling • cell-cell signaling • neuron-glial cell signaling • cell communication • cellular response to stimulus • positive regulation of cell communication • regulation of cellular process • positive regulation of signal transduction • positive regulation of biological process • regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • intracellular signaling cassette • signal transduction • positive regulation of cellular process • regulation of signaling • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • regulation of tube diameter • multicellular organismal process • system process • regulation of tube size • regulation of system process • positive regulation of vasoconstriction • circulatory system process • regulation of blood circulation • vascular process in circulatory system • regulation of vasoconstriction • positive regulation of multicellular organismal process • regulation of multicellular organismal process • blood vessel diameter maintenance • vasoconstriction • blood circulation • regulation of anatomical structure size • heart process • negative regulation of heart rate • regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback • regulation of heart contraction • negative regulation of biological process • negative regulation of blood pressure • negative regulation of systemic arterial blood pressure • nervous system process involved in regulation of systemic arterial blood pressure • regulation of heart rate • nervous system process • regulation of blood pressure • regulation of systemic arterial blood pressure by baroreceptor feedback • negative regulation of blood circulation • negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure • baroreceptor response to increased systemic arterial blood pressure • negative regulation of heart contraction • regulation of systemic arterial blood pressure • heart contraction • negative regulation of multicellular organismal process • phospholipase C-activating G protein-coupled receptor signaling pathway • phospholipase C-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • G protein-coupled receptor signaling pathway • regulation of systemic arterial blood pressure mediated by a chemical signal • positive regulation of blood pressure • positive regulation of blood circulation • regulation of systemic arterial blood pressure by norepinephrine-epinephrine • positive regulation of blood pressure by epinephrine-norepinephrine • positive regulation of heart rate • positive regulation of heart rate by epinephrine-norepinephrine • positive regulation of heart contraction • reflex • pilomotor reflex • modulation of chemical synaptic transmission • positive regulation of synaptic transmission, GABAergic • synaptic signaling • trans-synaptic signaling • synaptic transmission, GABAergic • positive regulation of synaptic transmission • chemical synaptic transmission • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • regulation of synaptic transmission, GABAergic • smooth muscle contraction • muscle contraction • muscle system process • apoptotic process • cell death • programmed cell death • norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure • regulation of action potential • positive regulation of action potential • action potential • regulation of membrane potential • adenylate cyclase-activating adrenergic receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • negative regulation of cell population proliferation • cell population proliferation • regulation of cell population proliferation • negative regulation of cellular process • muscle hypertrophy • regulation of muscle adaptation • positive regulation of cardiac muscle hypertrophy • striated muscle hypertrophy • regulation of muscle system process • regulation of cardiac muscle hypertrophy • regulation of muscle hypertrophy • muscle adaptation • positive regulation of muscle hypertrophy • cardiac muscle hypertrophy • negative regulation of catabolic process • negative regulation of metabolic process • autophagy • regulation of catabolic process • regulation of autophagy • negative regulation of autophagy • process utilizing autophagic mechanism • regulation of metabolic process • positive regulation of smooth muscle contraction • regulation of muscle contraction • regulation of smooth muscle contraction • positive regulation of muscle contraction • cellular developmental process • cardiac muscle cell development • developmental growth • cell development • organ growth • muscle cell differentiation • cell growth • striated muscle tissue development • muscle structure development • multicellular organism development • striated muscle cell development • muscle cell development • cell differentiation • anatomical structure development • cardiac cell development • muscle tissue development • cardiac muscle tissue growth • system development • developmental process • heart development • heart growth • developmental cell growth • cardiac muscle tissue development • physiological muscle hypertrophy • growth • animal organ development • cardiac muscle cell differentiation • tissue development • cardiocyte differentiation • circulatory system development • cell growth involved in cardiac muscle cell development • physiological cardiac muscle hypertrophy • striated muscle cell differentiation • regulation of the force of heart contraction by chemical signal • regulation of the force of heart contraction • positive regulation of the force of heart contraction by chemical signal • positive regulation of the force of heart contraction by epinephrine-norepinephrine • adult heart development • response to hormone • response to endogenous stimulus • positive regulation of cardiac muscle contraction • cardiac muscle contraction • striated muscle contraction • positive regulation of striated muscle contraction • regulation of cardiac muscle contraction • regulation of striated muscle contraction • host cellular component • host intracellular part • cellular anatomical structure • host cell cytoplasm • host cell part • host intracellular region • other organism part • membrane-bounded organelle • intracellular anatomical structure • nuclear membrane • membrane • nucleus • intracellular membrane-bounded organelle • endomembrane system
Gene Ontology	Cellular Component	• host cellular component • host intracellular part • cellular anatomical structure • host cell cytoplasm • host cell part • host intracellular region • other organism part • membrane-bounded organelle • intracellular anatomical structure • nuclear membrane • membrane • nucleus • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • organelle envelope • organelle • nuclear envelope • organelle membrane • cytoplasm • cytosol • membrane microdomain • cell periphery • membrane raft • plasma membrane raft • plasma membrane • plasma membrane region • caveola • membrane-enclosed lumen • intracellular organelle lumen • nucleoplasm • organelle lumen • nuclear lumen • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • synapse • cell junction • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • G-protein beta/gamma-subunit complex binding • signaling receptor binding • G protein-coupled receptor binding • cation binding • metal ion binding • GTPase regulator activity • enzyme regulator activity • enzyme activator activity • GTPase activator activity • molecular function activator activity • nucleoside-triphosphatase regulator activity • molecular function regulator activity • G protein activity • D1 dopamine receptor binding • dopamine receptor binding • cyclase regulator activity • cyclase activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • positive regulation of cell population proliferation • positive regulation of biological process • positive regulation of neural precursor cell proliferation • regulation of cell population proliferation • neural precursor cell proliferation • positive regulation of cellular process • regulation of neural precursor cell proliferation • reactive oxygen species metabolic process • regulation of superoxide metabolic process • positive regulation of reactive oxygen species metabolic process • superoxide metabolic process • positive regulation of metabolic process • superoxide anion generation • metabolic process • positive regulation of superoxide anion generation • regulation of superoxide anion generation • regulation of metabolic process • regulation of reactive oxygen species metabolic process • regulation of calcium ion transport • regulation of localization • transport • regulation of transport • regulation of monoatomic ion transport • establishment of localization • metal ion transport • calcium ion transport • localization • monoatomic ion transport • regulation of metal ion transport • monoatomic cation transport • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • regulation of signaling • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • negative regulation of signaling • negative regulation of biological process • negative regulation of G protein-coupled receptor signaling pathway • negative regulation of cell communication • negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • negative regulation of cellular process • regulation of G protein-coupled receptor signaling pathway • adenylate cyclase-activating adrenergic receptor signaling pathway • negative regulation of response to stimulus • negative regulation of signal transduction • negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway • regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell division • regulation of body fluid levels • renal system process • positive regulation of urine volume • regulation of urine volume • regulation of biological quality • regulation of vascular associated smooth muscle cell proliferation • positive regulation of vascular associated smooth muscle cell proliferation • regulation of smooth muscle cell proliferation • smooth muscle cell proliferation • positive regulation of smooth muscle cell proliferation • muscle cell proliferation • vascular associated smooth muscle cell proliferation • gamma-aminobutyric acid signaling pathway • purinergic nucleotide receptor signaling pathway • cell surface receptor signaling pathway • G protein-coupled purinergic receptor signaling pathway • G protein-coupled adenosine receptor signaling pathway • regulation of molecular function • regulation of adenylate cyclase activity • regulation of catalytic activity • negative regulation of molecular function • negative regulation of catalytic activity • negative regulation of adenylate cyclase activity • regulated exocytosis • regulation of calcium ion-dependent exocytosis • negative regulation of transport • negative regulation of regulated secretory pathway • vesicle-mediated transport • regulation of regulated secretory pathway • secretion by cell • regulation of secretion by cell • negative regulation of secretion • negative regulation of exocytosis • negative regulation of secretion by cell • calcium-ion regulated exocytosis • secretion • negative regulation of calcium ion-dependent exocytosis • export from cell • regulation of vesicle-mediated transport • regulation of secretion • exocytosis • regulation of exocytosis • regulation of programmed cell death • negative regulation of apoptotic signaling pathway • negative regulation of programmed cell death • regulation of apoptotic process • cell death • apoptotic signaling pathway • negative regulation of apoptotic process • apoptotic process • programmed cell death • regulation of apoptotic signaling pathway • positive regulation of locomotion • regulation of cell motility • positive regulation of cell migration • regulation of locomotion • positive regulation of cell motility • regulation of cell migration • cell migration • cell motility • locomotion • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • trans-synaptic signaling • modulation of chemical synaptic transmission • negative regulation of synaptic transmission • chemical synaptic transmission • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • response to nutrient levels • response to nutrient • regulation of Wnt signaling pathway • regulation of canonical Wnt signaling pathway • canonical Wnt signaling pathway • Wnt signaling pathway • neuropeptide signaling pathway • wound healing • hemostasis • blood coagulation • response to stress • coagulation • response to wounding • regulation of protein stability • protein stabilization • phospholipase C-activating serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • rhythmic process • entrainment of circadian clock • circadian rhythm • response to external stimulus • regulation of circadian rhythm • glutamate receptor signaling pathway • detection of light stimulus • response to light stimulus • phototransduction • detection of external stimulus • detection of visible light • detection of abiotic stimulus • detection of stimulus • response to abiotic stimulus • response to radiation • phototransduction, visible light • cell activation • regulation of cell activation • regulation of platelet activation • regulation of multicellular organismal process • platelet activation • phospholipase C-activating G protein-coupled glutamate receptor signaling pathway • G protein-coupled glutamate receptor signaling pathway • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • sensory perception of smell • response to peptide hormone • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • skeletal system development • bone development • homotypic cell-cell adhesion • platelet aggregation • cell adhesion • cell-cell adhesion • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • homeostatic process • adaptive thermogenesis • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • hormone secretion • protein localization to extracellular region • peptide secretion • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • regulation of protein transport • protein secretion • regulation of protein secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • insulin secretion • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • regulation of inflammatory response • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • positive regulation of catalytic activity • positive regulation of lyase activity • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • midbody • dense core granule • intracellular vesicle • cytoplasmic vesicle • secretory granule • secretory vesicle • neuronal dense core vesicle • centrosome • microtubule organizing center • cytoskeleton • membraneless organelle • intracellular membraneless organelle • microtubule cytoskeleton • somatodendritic compartment • dendrite • dendritic tree • neuron to neuron synapse • hippocampal mossy fiber to CA3 synapse • cell body • ciliary basal body • Golgi apparatus • cytosolic region • postsynapse • postsynaptic cytosol • Golgi apparatus subcompartment • organelle subcompartment • trans-Golgi network membrane • trans-Golgi network
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	ALE
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	ALE
Name	Epinephrine
Synonyms	Adrenaline
Identifier
Formula	C9 H13 N O3
Molecular Weight	183.204
SMILES
PubChem	139148732
Formal Charge	0
Total Atoms	26
Total Chiral Atoms	1
Total Bonds	26
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P35348
Sequence	>8THL_nogp_Chain_R L G G L I L F G V L G N I L V I L S V A C H R H L H S V T H Y Y I V N L A V A D L L L T S T V L P F S A I F E V L G Y W A F G R V F C N I W A A V D V L C C T A S I M G L C I I S I D R Y I G V S Y P L R Y P T I V T Q R R G L M A L L C V W A L S L V I S I G P L F G W R Q P A P E D E T I C Q I N E E P G Y V L F S A L G S F Y L P L A I I L V M Y C R V Y V V A K R E S K K A A K T L G I V V G C F V L C W L P F F L V M P I G S F F P D F K P S E T V F K I V F W L G Y L N S C I N P I I Y P C Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9M4Q	A	Amine	Adrenegic	Alpha1A	Homo sapiens	Doxazosin	-	-	2.99	2025-07-02	doi.org/10.1016/j.jbc.2025.110348
	9M4T	A	Amine	Adrenegic	Alpha1A	Homo sapiens	Silodosin	-	-	3.19	2025-07-02	doi.org/10.1016/j.jbc.2025.110348
	7YM8	A	Amine	Adrenergic	Alpha1A	Homo sapiens	Oxymetazoline	-	chim(Gs-CtGq)	2.92	2023-07-05	doi.org/10.1038/s41467-023-39310-x
	7YM8 (No Gprot)	A	Amine	Adrenergic	Alpha1A	Homo sapiens	Oxymetazoline	-		2.92	2023-07-05	doi.org/10.1038/s41467-023-39310-x
	7YMH	A	Amine	Adrenergic	Alpha1A	Homo sapiens	Norepinephrine	-	chim(Gs-CtGq)	3.52	2023-07-05	doi.org/10.1038/s41467-023-39310-x
	7YMH (No Gprot)	A	Amine	Adrenergic	Alpha1A	Homo sapiens	Norepinephrine	-		3.52	2023-07-05	doi.org/10.1038/s41467-023-39310-x
	7YMJ	A	Amine	Adrenergic	Alpha1A	Homo sapiens	Tamsulosin	-	-	3.35	2023-07-05	doi.org/10.1038/s41467-023-39310-x
	8THK	A	Amine	Adrenergic	Alpha1A	Homo sapiens	A61603	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	2.6	2023-08-16	doi.org/10.1038/s41467-023-40524-2
	8THK (No Gprot)	A	Amine	Adrenergic	Alpha1A	Homo sapiens	A61603	-		2.6	2023-08-16	doi.org/10.1038/s41467-023-40524-2
	8THL	A	Amine	Adrenergic	Alpha1A	Homo sapiens	Epinephrine	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.1	2023-08-16	doi.org/10.1038/s41467-023-40524-2
	8THL (No Gprot)	A	Amine	Adrenergic	Alpha1A	Homo sapiens	Epinephrine	-		3.1	2023-08-16	doi.org/10.1038/s41467-023-40524-2
	8HN1	A	Amine	Adrenergic	Alpha1A	Homo sapiens	Toxin AdTx1	-	-	2.9	2023-12-20	To be published
	9IQV	A	Amine	Adrenegic	Alpha1A	Homo sapiens	-	Muscarinic toxin 3	-	3.3	2025-07-23	To be published

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