Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 4LDO | A | Amine | Adrenergic | Beta2 | Homo sapiens | L-Epinephrine | - | - | 3.2 | 2013-09-25 | 10.1038/nature12572 |
![](/psngpcr/ligands/ALE/ALE_4LDO_L_L_402.png)
A 2D representation of the interactions of ALE in 4LDO colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:M82 | R:R:V86 | 4.56 | 1 | Yes | No | 7 | 7 | 2 | 2 | R:R:M82 | R:R:Y316 | 7.18 | 1 | Yes | Yes | 7 | 6 | 2 | 1 | R:R:D113 | R:R:V86 | 7.3 | 1 | No | No | 7 | 7 | 1 | 2 | R:R:V86 | R:R:Y316 | 5.05 | 1 | No | Yes | 7 | 6 | 2 | 1 | R:R:D113 | R:R:Y316 | 10.34 | 1 | No | Yes | 7 | 6 | 1 | 1 | L:L:?402 | R:R:D113 | 22.15 | 1 | Yes | No | 0 | 7 | 0 | 1 | R:R:V114 | R:R:Y199 | 3.79 | 0 | No | Yes | 5 | 6 | 1 | 2 | L:L:?402 | R:R:V114 | 11.44 | 1 | Yes | No | 0 | 5 | 0 | 1 | R:R:V117 | R:R:W286 | 9.81 | 0 | No | Yes | 6 | 8 | 1 | 2 | L:L:?402 | R:R:V117 | 10.01 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:F193 | R:R:T195 | 6.49 | 0 | No | No | 4 | 3 | 1 | 2 | R:R:F193 | R:R:Y308 | 4.13 | 0 | No | Yes | 4 | 5 | 1 | 2 | L:L:?402 | R:R:F193 | 15.2 | 1 | Yes | No | 0 | 4 | 0 | 1 | R:R:T195 | R:R:Y199 | 3.75 | 2 | No | Yes | 3 | 6 | 2 | 2 | R:R:S203 | R:R:Y199 | 5.09 | 0 | No | Yes | 5 | 6 | 1 | 2 | L:L:?402 | R:R:S203 | 7.21 | 1 | Yes | No | 0 | 5 | 0 | 1 | R:R:F290 | R:R:S204 | 5.28 | 1 | Yes | No | 7 | 5 | 1 | 2 | R:R:N293 | R:R:S204 | 4.47 | 1 | Yes | No | 5 | 5 | 1 | 2 | R:R:F208 | R:R:F290 | 20.36 | 1 | Yes | Yes | 8 | 7 | 2 | 1 | R:R:F289 | R:R:W286 | 7.02 | 1 | Yes | Yes | 6 | 8 | 1 | 2 | R:R:F290 | R:R:W286 | 5.01 | 1 | Yes | Yes | 7 | 8 | 1 | 2 | R:R:F289 | R:R:F290 | 13.93 | 1 | Yes | Yes | 6 | 7 | 1 | 1 | R:R:F289 | R:R:N293 | 8.46 | 1 | Yes | Yes | 6 | 5 | 1 | 1 | R:R:F289 | R:R:Y308 | 8.25 | 1 | Yes | Yes | 6 | 5 | 1 | 2 | R:R:F289 | R:R:N312 | 14.5 | 1 | Yes | No | 6 | 5 | 1 | 1 | L:L:?402 | R:R:F289 | 10.52 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | L:L:?402 | R:R:F290 | 9.35 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:N293 | R:R:Y308 | 9.3 | 1 | Yes | Yes | 5 | 5 | 1 | 2 | L:L:?402 | R:R:N293 | 5.27 | 1 | Yes | Yes | 0 | 5 | 0 | 1 | R:R:N312 | R:R:Y316 | 10.47 | 1 | No | Yes | 5 | 6 | 1 | 1 | L:L:?402 | R:R:N312 | 18.45 | 1 | Yes | No | 0 | 5 | 0 | 1 | R:R:W313 | R:R:Y316 | 14.47 | 1 | Yes | Yes | 5 | 6 | 2 | 1 | L:L:?402 | R:R:Y316 | 7.88 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 10.00 | Average Number Of Links With An Hub | 4.00 | Average Interaction Strength | 11.75 | Average Nodes In Shell | 20.00 | Average Hubs In Shell | 11.00 | Average Links In Shell | 33.00 | Average Links Mediated by Hubs In Shell | 31.00 |
| ![](/psngpcr/ligands/ALE/ALE_4LDO_L_L_402_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/ALE/ALE_4LDO_L_L_402_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7BTS | A | Amine | Adrenergic | Beta1 | Homo sapiens | L-Epinephrine | - | - | 3.13 | 2020-12-02 | 10.1038/s41422-020-00424-2 |
![](/psngpcr/ligands/ALE/ALE_7BTS_L_L_401.png)
A 2D representation of the interactions of ALE in 7BTS colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:M107 | R:R:V111 | 4.56 | 0 | Yes | Yes | 7 | 7 | 2 | 2 | R:R:M107 | R:R:V142 | 4.56 | 0 | Yes | Yes | 7 | 6 | 2 | 1 | R:R:D138 | R:R:V111 | 8.76 | 1 | Yes | Yes | 7 | 7 | 1 | 2 | R:R:V111 | R:R:Y367 | 3.79 | 1 | Yes | Yes | 7 | 8 | 2 | 1 | R:R:V112 | R:R:Y367 | 5.05 | 0 | No | Yes | 7 | 8 | 2 | 1 | R:R:D138 | R:R:V142 | 4.38 | 1 | Yes | Yes | 7 | 6 | 1 | 1 | R:R:D138 | R:R:Y367 | 10.34 | 1 | Yes | Yes | 7 | 8 | 1 | 1 | L:L:?401 | R:R:D138 | 19.54 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:S190 | R:R:V139 | 3.23 | 4 | No | No | 7 | 7 | 2 | 1 | R:R:V139 | R:R:Y224 | 3.79 | 0 | No | Yes | 7 | 7 | 1 | 2 | L:L:?401 | R:R:V139 | 18.59 | 1 | Yes | No | 0 | 7 | 0 | 1 | R:R:V142 | R:R:W337 | 9.81 | 1 | Yes | Yes | 6 | 8 | 1 | 2 | L:L:?401 | R:R:V142 | 8.58 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:S232 | R:R:T143 | 9.59 | 0 | No | Yes | 7 | 7 | 1 | 2 | R:R:F218 | R:R:W199 | 7.02 | 1 | Yes | Yes | 6 | 6 | 1 | 2 | R:R:W199 | R:R:Y224 | 4.82 | 1 | Yes | Yes | 6 | 7 | 2 | 2 | R:R:F218 | R:R:N344 | 3.62 | 1 | Yes | Yes | 6 | 6 | 1 | 1 | R:R:F218 | R:R:F359 | 3.22 | 1 | Yes | Yes | 6 | 5 | 1 | 2 | L:L:?401 | R:R:F218 | 16.37 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:S228 | R:R:Y224 | 11.45 | 0 | No | Yes | 6 | 7 | 1 | 2 | L:L:?401 | R:R:S228 | 10.09 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:S229 | R:R:Y234 | 3.82 | 1 | Yes | Yes | 7 | 5 | 2 | 2 | R:R:F341 | R:R:S229 | 5.28 | 1 | Yes | Yes | 7 | 7 | 1 | 2 | R:R:N344 | R:R:S229 | 4.47 | 1 | Yes | Yes | 6 | 7 | 1 | 2 | L:L:?401 | R:R:S232 | 8.65 | 1 | Yes | No | 0 | 7 | 0 | 1 | R:R:F233 | R:R:Y234 | 9.28 | 1 | Yes | Yes | 8 | 5 | 2 | 2 | R:R:F233 | R:R:F341 | 21.43 | 1 | Yes | Yes | 8 | 7 | 2 | 1 | R:R:F341 | R:R:Y234 | 3.09 | 1 | Yes | Yes | 7 | 5 | 1 | 2 | R:R:F340 | R:R:W337 | 5.01 | 1 | Yes | Yes | 7 | 8 | 1 | 2 | R:R:F341 | R:R:W337 | 10.02 | 1 | Yes | Yes | 7 | 8 | 1 | 2 | R:R:F340 | R:R:F341 | 11.79 | 1 | Yes | Yes | 7 | 7 | 1 | 1 | R:R:F340 | R:R:N344 | 8.46 | 1 | Yes | Yes | 7 | 6 | 1 | 1 | R:R:F340 | R:R:F359 | 7.5 | 1 | Yes | Yes | 7 | 5 | 1 | 2 | R:R:F340 | R:R:N363 | 15.71 | 1 | Yes | No | 7 | 6 | 1 | 1 | L:L:?401 | R:R:F340 | 8.18 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | L:L:?401 | R:R:F341 | 8.18 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:F359 | R:R:N344 | 3.62 | 1 | Yes | Yes | 5 | 6 | 2 | 1 | L:L:?401 | R:R:N344 | 6.59 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:N363 | R:R:Y367 | 11.63 | 1 | No | Yes | 6 | 8 | 1 | 1 | L:L:?401 | R:R:N363 | 14.5 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:W364 | R:R:Y367 | 15.43 | 1 | Yes | Yes | 7 | 8 | 2 | 1 | L:L:?401 | R:R:Y367 | 4.5 | 1 | Yes | Yes | 0 | 8 | 0 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 11.00 | Average Number Of Links With An Hub | 7.00 | Average Interaction Strength | 11.25 | Average Nodes In Shell | 25.00 | Average Hubs In Shell | 19.00 | Average Links In Shell | 42.00 | Average Links Mediated by Hubs In Shell | 41.00 |
| ![](/psngpcr/ligands/ALE/ALE_7BTS_L_L_401_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/ALE/ALE_7BTS_L_L_401_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8THL | A | Amine | Adrenergic | Alpha1A | Homo Sapiens | Epinephrine | - | chim(NtGi2L-Gs-CtGq)/Beta1/Gamma2 | 3.1 | 2023-08-16 | 10.1038/s41467-023-40524-2 |
![](/psngpcr/ligands/ALE/ALE_8THL_L_L_1.png)
A 2D representation of the interactions of ALE in 8THL colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:C110 | R:R:L75 | 3.17 | 1 | No | No | 6 | 8 | 1 | 2 | R:R:D106 | R:R:V79 | 13.15 | 1 | No | Yes | 7 | 8 | 1 | 2 | R:R:V79 | R:R:Y316 | 3.79 | 1 | Yes | Yes | 8 | 7 | 2 | 1 | R:R:L80 | R:R:Y316 | 4.69 | 0 | No | Yes | 8 | 7 | 2 | 1 | R:R:S83 | R:R:W313 | 6.18 | 1 | No | Yes | 7 | 6 | 2 | 2 | R:R:S83 | R:R:Y316 | 7.63 | 1 | No | Yes | 7 | 7 | 2 | 1 | R:R:D106 | R:R:Y316 | 10.34 | 1 | No | Yes | 7 | 7 | 1 | 1 | L:L:?1 | R:R:D106 | 16.94 | 1 | Yes | No | 0 | 7 | 0 | 1 | R:R:S158 | R:R:V107 | 3.23 | 0 | No | No | 8 | 6 | 2 | 1 | R:R:V107 | R:R:Y184 | 3.79 | 0 | No | Yes | 6 | 8 | 1 | 2 | L:L:?1 | R:R:V107 | 10.01 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:C110 | R:R:W285 | 5.22 | 1 | No | Yes | 6 | 8 | 1 | 1 | L:L:?1 | R:R:C110 | 9.14 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:F281 | R:R:I114 | 3.77 | 1 | Yes | No | 9 | 8 | 2 | 2 | R:R:I114 | R:R:W285 | 15.27 | 1 | No | Yes | 8 | 8 | 2 | 1 | R:R:F312 | R:R:I178 | 5.02 | 1 | Yes | No | 6 | 6 | 1 | 2 | R:R:S188 | R:R:Y184 | 12.72 | 0 | No | Yes | 7 | 8 | 1 | 2 | R:R:M292 | R:R:V185 | 6.09 | 0 | No | No | 7 | 6 | 1 | 2 | L:L:?1 | R:R:S188 | 7.21 | 1 | Yes | No | 0 | 7 | 0 | 1 | R:R:F289 | R:R:S192 | 5.28 | 1 | Yes | No | 7 | 6 | 1 | 2 | R:R:F193 | R:R:F281 | 4.29 | 1 | Yes | Yes | 8 | 9 | 2 | 2 | R:R:F193 | R:R:W285 | 5.01 | 1 | Yes | Yes | 8 | 8 | 2 | 1 | R:R:F193 | R:R:F289 | 18.22 | 1 | Yes | Yes | 8 | 7 | 2 | 1 | R:R:F281 | R:R:W285 | 5.01 | 1 | Yes | Yes | 9 | 8 | 2 | 1 | R:R:F289 | R:R:W285 | 5.01 | 1 | Yes | Yes | 7 | 8 | 1 | 1 | R:R:G315 | R:R:W285 | 8.44 | 0 | No | Yes | 7 | 8 | 2 | 1 | R:R:N318 | R:R:W285 | 7.91 | 0 | No | Yes | 9 | 8 | 2 | 1 | L:L:?1 | R:R:W285 | 5.47 | 1 | Yes | Yes | 0 | 8 | 0 | 1 | R:R:F288 | R:R:V311 | 9.18 | 1 | No | No | 7 | 5 | 1 | 2 | R:R:F288 | R:R:F312 | 16.08 | 1 | No | Yes | 7 | 6 | 1 | 1 | L:L:?1 | R:R:F288 | 11.69 | 1 | Yes | No | 0 | 7 | 0 | 1 | L:L:?1 | R:R:F289 | 10.52 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:M292 | R:R:P293 | 11.74 | 0 | No | No | 7 | 6 | 1 | 2 | L:L:?1 | R:R:M292 | 6.79 | 1 | Yes | No | 0 | 7 | 0 | 1 | R:R:F308 | R:R:F312 | 3.22 | 0 | No | Yes | 4 | 6 | 2 | 1 | R:R:F312 | R:R:Y316 | 5.16 | 1 | Yes | Yes | 6 | 7 | 1 | 1 | L:L:?1 | R:R:F312 | 12.86 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:W313 | R:R:Y316 | 8.68 | 1 | Yes | Yes | 6 | 7 | 2 | 1 | L:L:?1 | R:R:Y316 | 9 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:A189 | R:R:F289 | 2.77 | 0 | No | Yes | 7 | 7 | 2 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 10.00 | Average Number Of Links With An Hub | 4.00 | Average Interaction Strength | 9.96 | Average Nodes In Shell | 30.00 | Average Hubs In Shell | 10.00 | Average Links In Shell | 40.00 | Average Links Mediated by Hubs In Shell | 35.00 |
| ![](/psngpcr/ligands/ALE/ALE_8THL_L_L_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/ALE/ALE_8THL_L_L_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|