Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
11x39 6.032517
22x42 4.185507
32x46 5.441519
42x50 7.425519
52x53 3.94875417
62x56 5.513517
72x59 4.27125416
82x60 5.598516
92x64 6.70917614
10E1x50 8.60917618
11E1x52 7.34375417
123x28 4.6415
133x29 7.00625415
143x30 4.28375406
153x32 5.91416
163x37 3.54125416
173x41 4.385415
183x50 4.501509
193x51 8.1975408
20I2x50 2.665408
214x61 5.369515
22E2 28.6551213
235x35 8.13875411
245x44 6.04625416
255x461 5.146516
265x58 7.1875128
275x60 3.29625403
285x61 3.2245128
295x70 4.57125403
305x72 4.75125425
31I3 4.712081224
326x23 3.805423
336x30 6.09527
346x48 7.5825418
356x52 6.09375417
366x55 5.163515
37E3 14.2144813
387x30 4.999514
397x31 6.25514
407x38 6.8575615
417x42 4.0675417
427x45 7.235419
437x49 7.474519
448x50 3.73125409
458x54 8.048754177
46G.HN.11 3.037502
47G.H1.04 8.908527
48G.h1ha.04 6.4756197
49H.HA.10 3.2325404
50H.HA.16 3.1055234
51H.hdhe.01 4.92625406
52H.HE.04 8.29625499
53H.HE.05 5.97496
54H.hehf.06 3.80875409
55H.HF.03 5.8599
56H.HF.06 12.315496
57G.hfs2.01 3.224505
58G.S2.01 4.972539
59G.S3.01 3.44254184
60G.S3.03 7.1045187
61G.S3.08 4.712539
62G.s3h2.03 6.105439
63G.H2.04 6.622539
64G.H2.06 6.91286739
65G.H2.07 7.97539
66G.h2s4.01 6.401539
67G.h2s4.02 5.384107
68G.S4.02 5.1325407
69G.S4.03 3.652527
70G.s4h3.01 5.358527
71G.s4h3.04 5.23286728
72G.s4h3.05 6.235629
73G.s4h3.08 6.24158
74G.H3.01 8.2525409
75G.H3.09 6.998509
76G.H3.12 6.38537
77G.H3.15 5.504538
78G.H3.17 5.656505
79G.H3.18 6.32409
80G.S5.03 3.952528
81G.S5.05 4.808529
82G.S5.06 6.325428
83G.S5.07 7.93529
84G.s5hg.01 4.946529
85G.HG.07 7.08571729
86G.HG.08 2.81406
87G.HG.13 4.045426
88G.HG.15 5.4525406
89G.hgh4.02 4.6985138
90G.hgh4.05 6.785406
91G.H4.08 7.735425
92G.H4.10 6.6545137
93G.H4.11 4.6975408
94G.H4.12 4.8775425
95G.H4.14 7.19754135
96G.S6.02 7.44857728
97G.S6.04 7.54375429
98G.S6.05 6.9675625
99G.s6h5.01 8.0675429
100G.s6h5.05 6.99429
101G.H5.03 7.54667628
102G.H5.13 7.27875427
103G.H5.19 3.80375408
104G.H5.20 3.56408
105G.H5.23 9.5225404
106G.H5.26 3.501508
107b.lhb1x6 4.54917673
108b.lhb1x9 3.15125473
109b.lhb1x11 3.45375474
110b.b1x6 7.142559
111b.l1x3 9.462559
112b.b2x1 8.5365108
113b.b2x5 7.056557
114b.b3x2 5.49455
115b.l3x2 4.98459
116b.b4x2 4.6575408
117b.b4x3 4.0885167
118b.b4x4 8.75125458
119b.b4x5 3.59375407
120b.b4x6 9.495659
121b.l4x2 13.4112454
122b.b5x2 7.585407
123b.b5x3 7.557559
124b.b5x5 4.9225405
125b.b5x7 4.866507
126b.l5x1 5.15754168
127b.l5x5 6.10833939
128b.b6x5 4.8475406
129b.b7x1 7.0025214
130b.b7x4 3.484168
131b.l7x2 4.5975439
132b.b8x3 3.91254216
133b.b8x4 4.9625166
134b.b9x4 5.35409
135b.l9x3 7.7125639
136b.l9x6 5.60071738
137b.b10x3 4.2625438
138b.b10x5 4.617147219
139b.l10x1 4.82254223
140b.b11x2 5407
141b.b11x4 5.304539
142b.b11x5 4.42466
143b.l11x2 8.724539
144b.b12x2 4.90625437
145b.b12x3 3.81468
146b.b12x6 10.336538
147b.b13x7 9.006567
148b.l13x3 7.28571769
149b.l13x6 5.315539
150b.l13x7 3.9125469
151b.b14x3 5.54465
152b.b15x1 7.954569
153b.b15x2 7.91446
154b.b15x3 4.6075469
155b.l15x1 4.34437
156b.l15x2 6.366569
157b.b16x4 11.495466
158b.b16x5 5.678545
159b.b16x6 8.00429768
160b.b16x7 10.1575449
161b.b17x4 5.1275445
162b.b17x5 6.8825447
163b.b17x7 8.045448
164b.l17x3 10.31649
165b.l17x6 9.68125439
166b.l17x7 5.165447
167b.b18x3 5.8625448
168b.l18x1 7.200836146
169b.l18x2 7.0854147
170b.b19x2 7.516546
171b.b19x4 5.418548
172b.l19x2 8.202549
173b.b20x2 6.41446
174b.b20x4 10.275648
175b.b20x6 6.505646
176b.b20x7 4.565409
177b.l20x2 8.64125409
178b.b21x1 7.70625447
179b.b21x2 2.75375406
180b.b21x7 5.07571705
181b.l21x5 4.498584
182b.b22x5 4.945147
183b.l22x5 7.85579
184b.b23x1 4.23375475
185b.b23x6 6.66143787
186b.l23x1 9.1375406
187b.b24x3 4.24875475
188b.b24x4 7.334586
189b.b24x6 6.9725488
190b.l24x3 3.945405
191b.b25x3 8.8975485
192b.l25x3 8.316579
193b.l26x1 7.695457
194b.l26x5 8.29667655
195b.b27x1 4.274506
196b.b27x3 5.4175408
197b.l27x1 11.60147109
198b.l27x2 7.955479
199b.b28x3 4.8457
200b.b28x4 7.1325476
201b.b28x6 8.15833679
202g.h1x10 4.5975409
203g.h1x11 1.20125409
204g.h2x11 9.001254146
205g.ctx3 6.567509
206g.ctx6 3.90625476
207g.ctx14 5.96409
208g.ctx16 6.17667658
209Lig 11.79042710
210H.hahb.06 3.986500
211H.hahb.08 4.6425110
212H.HB.02 3.9325110
213H.HB.10 4.53875400
214H.HC.11 3.9375400
215H.hchd.01 3.2425110
216H.HD.07 5.1425400
217H.HE.11 4.195490
218H.hehf.04 4.17375400
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
16x48 Lig 19.64294.03YesYes180
26x44 6x48 21.383213.03NoYes198
35x51 6x44 24.85166.7NoNo069
45x51 5x55 25.11533.75NoNo065
55x55 6x41 25.24713.23NoNo057
65x58 6x41 25.77193.79YesNo087
75x58 5x61 39.62873.63YesYes1288
83x54 5x61 40.96282.94NoYes1288
93x54 G.H5.20 41.22442.85NoYes088
103x50 5x58 13.25758.23YesYes098
11G.H5.17 G.H5.20 44.05462.66NoYes058
126x30 G.H5.17 44.18279.345YesNo075
136x30 G.H5.13 22.35249.53YesYes277
145x72 6x30 22.21454.855YesYes257
155x72 I3 22.18164.93YesYes254
16G.H5.13 I3 22.18075.635YesYes274
17G.S6.05 I3 47.350910.495YesYes254
18G.S5.06 G.S6.05 46.96877.31YesYes285
19G.S5.04 G.S5.06 64.93055.54NoYes088
20G.H3.09 G.S5.04 64.97333.65YesNo098
21G.H3.09 G.S4.04 66.491210.72YesNo099
22G.H3.12 G.S4.04 66.011410.05YesNo379
23G.H2.04 G.H3.12 62.21386.26YesYes397
24G.H2.04 G.H2.07 85.087311YesYes399
25G.H2.02 G.H2.07 86.43816.18NoYes389
26G.H2.02 b.l9x6 43.27695.09NoYes388
27b.l11x1 b.l9x6 56.81998.69NoYes398
28b.b11x6 b.l11x1 1003.71NoNo399
29b.b11x6 b.l9x3 99.596813.95NoYes399
30b.b11x4 b.l9x3 67.30716.85YesYes399
31b.b11x4 b.b8x1 16.07073.38YesNo398
32b.b8x1 b.b9x4 16.02873.17NoYes089
33b.b8x3 b.b9x4 46.80522.85YesYes069
34b.b7x1 b.b8x3 46.64994.84YesYes2146
35b.b7x1 b.l6x5 91.28613.49YesNo044
36b.l6x3 b.l6x5 90.64547.45NoNo064
37b.l6x3 b.l6x4 90.00453.71NoNo065
38b.b6x5 b.l6x4 89.68415.79YesNo065
39b.b6x5 b.l2x3 88.40193.45YesNo068
40b.b3x1 b.l2x3 88.08138.14NoNo058
41b.b3x1 b.b5x4 87.76072.98NoNo055
42b.b5x4 b.b5x5 87.446.23NoYes055
43b.b4x5 b.b5x5 54.40423.975YesYes075
44b.b3x3 b.b4x5 22.0144.61NoYes087
45b.b3x3 b.b6x3 19.75125.12NoNo088
46b.b2x2 b.b6x3 19.10151.81NoNo078
47b.b26x2 b.b2x2 18.77731.81NoNo077
48b.b26x2 b.b2x3 18.45326.48NoNo076
49b.b27x2 b.b2x3 18.12943.22NoNo056
50b.b27x2 b.b2x5 17.80573.89NoYes057
51b.l4x1 g.ctx16 18.44034.62NoYes558
52b.l4x2 g.ctx16 27.48437.22YesYes548
53b.l2x5 b.l4x2 31.01728.81NoYes054
54b.b4x7 b.l2x5 29.067715.48NoNo085
55b.b4x7 b.l4x3 27.118311.56NoNo086
56b.b5x2 b.l4x3 25.168911.7YesNo076
57G.HN.37 b.b5x2 19.32066.65NoYes037
58G.HN.11 G.HN.37 15.42151.49YesNo023
59G.H2.02 b.l13x6 43.19082.945NoYes389
60b.l11x1 b.l13x6 43.20736.71NoYes399
61b.b11x4 b.b12x6 32.0918.49YesYes398
62b.b12x6 b.b9x4 32.042313.67YesYes089
63b.b12x4 b.l9x3 32.2332.93NoYes349
64b.b12x4 b.b12x6 32.08085.19NoYes348
65b.b10x3 b.b11x4 19.13383.38YesYes389
66b.b10x3 b.b11x2 16.26983.27YesYes087
67b.b10x5 b.b11x2 47.98728.79YesYes097
68b.b10x5 b.b7x1 46.87793.09YesYes2194
69b.b11x2 b.b12x6 32.04563.52YesYes078
70b.b4x5 b.b5x7 31.42582.94YesYes077
71b.b5x7 b.b5x8 52.49123.39YesNo075
72b.b4x2 b.b5x8 51.84383.35YesNo085
73G.HN.47 b.b4x2 42.11113.525NoYes068
74G.HN.47 b.b4x4 35.61743.565NoYes068
75b.b4x4 b.b4x6 30.427615.27YesYes589
76b.b3x2 b.b4x6 13.60654.56YesYes559
77b.b3x2 b.l4x1 12.94753YesNo555
78b.b5x5 b.l8x8 32.39465.535YesNo054
79b.b5x7 b.l8x8 31.42467.68YesNo074
80b.b1x6 b.b4x6 15.54615.94YesYes599
81b.b1x6 b.b28x5 13.60554.28YesNo595
82b.b28x5 g.ctx16 12.30636.91NoYes558
83b.b2x5 b.l26x1 10.696410.92YesYes577
84G.s5hg.01 H.hdhe.05 19.57162.77YesNo298
85G.hfs2.02 H.hdhe.05 19.27785.22NoNo298
86G.hfs2.02 H.hdhe.04 19.13378.66NoNo097
87H.HE.01 H.hdhe.04 11.89174.89NoNo097
88G.HG.04 G.s4h3.01 17.70566.92NoYes087
89G.HG.04 G.s4h3.04 17.64044.69NoYes088
90G.HG.07 G.s4h3.04 15.97798.36YesYes298
91b.l7x2 b.l9x6 13.61073.52YesYes398
92G.H2.04 G.H2.08 11.34935.01YesNo098
93G.H3.15 G.H3.17 15.04432.89YesYes085
94G.H3.17 b.l25x6 25.74914.5YesNo058
95b.l25x6 b.l27x1 11.201423.99NoYes089
96b.b2x1 b.l3x1 11.71379.02YesNo089
97b.l23x1 b.l25x6 36.641522.63YesNo068
98b.l21x7 b.l23x1 24.65823.11NoYes056
99b.b23x6 b.l21x7 23.24094.03YesNo875
100b.b23x6 b.l21x9 11.94127.25YesNo076
101b.b19x5 b.l21x9 11.63345.29NoNo056
102b.b19x4 b.b19x5 11.45471.82YesNo085
103b.b22x1 b.l23x1 11.75895.78NoYes086
104b.b22x1 b.b22x2 11.58074.8NoNo088
105b.b22x2 b.b26x3 11.40243NoNo086
106G.S5.06 G.s4h3.01 17.63338.3YesYes287
107G.H2.08 G.H3.17 11.28674.7NoYes085
108G.H2.04 G.H3.15 11.38447.2YesYes398
109b.b2x1 b.l27x1 11.377411.58YesYes1089
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
1x351x396.0450NoYes6722
1x352x643.0250NoYes6421
1x392x605.1751YesYes7621
1x397x383.091YesYes7521
1x397x424.131YesYes7721
2x532x564.761YesYes7711
2x533x3531YesNo7812
2x537x464.51YesNo7812
2x563x3210.681YesYes7611
2x567x424.891YesYes7711
2x56Lig5.5451YesYes7010
2x577x424.160NoYes7721
2x59E1x526.5551YesYes6722
2x593x284.611YesYes6522
2x593x324.31YesYes6621
2x602x634.171YesNo6511
2x602x649.1951YesYes6411
2x607x384.761YesYes6511
2x60Lig4.691YesYes6010
2x63E1x5051NoYes5811
2x63Lig15.2951NoYes5010
2x647x315.6751YesYes4411
2x647x343.181YesNo4412
2x647x354.231YesNo4412
2x64Lig14.951YesYes4010
E1E1x493.571NoNo4412
E1E24.181NoYes4311
E1Lig4.7051NoYes4010
E1x50E1x5215.031YesYes8712
3x25E1x505.221NoYes9821
E1x50E2x5017.631YesNo8911
E1x50Lig5.9651YesYes8010
3x28E1x526.281YesYes5722
3x22E214.311NoYes4321
3x25E23.171NoYes9321
3x25E2x507.281NoNo9921
3x283x293.391YesYes5521
3x283x324.121YesYes5621
3x294x613.1451YesYes5511
3x294x656.2351YesNo5511
3x29Lig15.2551YesYes5010
3x32Lig4.541YesYes6010
3x335x4618.531NoYes4612
3x33Lig5.041NoYes4010
3x363x373.681NoYes7612
3x365x4614.5851NoYes7612
3x36Lig5.511NoYes7010
3x375x4613.7651YesYes6622
4x614x654.311YesNo5511
4x61E2x527.0751YesNo5411
4x615x397.391YesNo5612
4x61Lig4.9251YesYes5010
4x65Lig4.881NoYes5010
E2E274.0351YesYes3311
E2E2x517.891YesNo3112
E2E370.131YesYes3311
E2Lig54.8051YesYes3010
E2x50Lig4.451NoYes9010
E2E2x5213.911YesNo3411
E2x52Lig17.9451NoYes4010
5x35E29.151YesYes1321
5x36E212.521NoYes3321
6x59E25.7251NoYes4321
5x355x364.581YesNo1322
5x395x436.971NoNo6622
5x396x554.91NoYes6521
5x406x555.091NoYes5521
5x406x596.521NoNo5422
5x436x553.181NoYes6521
5x445x478.251YesNo6822
5x446x529.6151YesYes6721
5x476x525.441NoYes8721
6x446x4813.031NoYes9821
6x447x456.041NoYes9922
6x486x524.231YesYes8711
6x487x459.041YesYes8912
6x48Lig4.031YesYes8010
6x517x389.041NoYes5511
6x517x415.471NoNo5812
6x51Lig8.1651NoYes5010
6x52Lig5.091YesYes7010
6x546x586.261NoNo5422
6x547x385.6351NoYes5521
6x556x596.9951YesNo5412
6x55Lig5.651YesYes5010
6x57E35.1751NoYes4321
6x577x303.271NoYes4421
6x587x307.91NoYes4421
6x587x386.931NoYes4521
E3E37.341YesYes3311
E3Lig14.131YesYes3010
7x27E35.890NoYes3321
7x30E33.151YesYes4311
7x307x346.971YesNo4412
7x30Lig3.7051YesYes4010
7x317x357.541YesNo4412
7x31Lig15.5351YesYes4010
7x38Lig11.691YesYes5010
7x42Lig3.091YesYes7010
2x53Lig3.5351YesYes7010
3x21E1x502.810NoYes8821
2x5512x561.690NoYes5721
1x317x311.260NoYes4421
7x287x311.240NoYes3421
5x33E30.560NoYes1321

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
100.00Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
100.00Consensusbombesin_onOrthosteric Ligandbb2_on
100.00Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
80.77Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
73.08Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
67.86Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
58.06Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
54.84Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
53.85Consensusendothelin_offOrthosteric Ligandetb_off
53.85Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
53.57Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
53.33Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
53.33Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
51.72Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
50.00Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
50.00Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
50.00Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
50.00Single8PKMBefiradol8PKM-5-HT1A-Befiradol-t7m-Gi1/β1/γ1
50.00Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
50.00Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
50.00Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
50.00Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
50.00Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
48.28Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
48.15Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
48.15Single5X93K-87945X93-ETB-K-8794
48.15Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
46.88Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
46.88Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
46.88Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
46.88Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
46.67Single6PT2KGCHM076PT2-δ-KGCHM07
46.67Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
46.67Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
46.67Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
46.67Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
46.43Single4UG2CGS216804UG2-A2A-CGS21680
46.43Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
46.43Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
46.43Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
46.43Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
46.15Single6TQ7SB-3348676TQ7-OX1-SB-334867
46.15Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
46.15Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
46.15Single8XVLZibotentan8XVL-ETA-Zibotentan
45.45Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
45.45Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
45.45Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
45.45Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
45.45Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
45.16Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
45.16Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
44.83Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
44.83Single7F8XNN90567F8X-CCKA-NN9056
44.83Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
44.83Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
44.83Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
44.44Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
44.44Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
44.44Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
44.44Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
44.44Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
44.44Consensusorexin_onOrthosteric Ligandox2_on
44.12Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
44.00Single5DHHSB-6121115DHH-NOP-SB-612111
43.75Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
43.75Single8ZRTET-18ZRT-ETB-ET-1
43.75Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
43.75Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
43.33Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
43.33Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
43.33Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
43.33Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
43.33Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
43.33Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
42.86Single6IGKEndothelin-36IGK-ETB-Endothelin-3
42.86Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
42.86Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
42.86Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
42.86Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
42.86Consensuscck_onOrthosteric Ligandccka_on cckb_on
42.86Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
42.86Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
42.86Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
42.86Consensusprostanoid_offOrthosteric Ligandep_off dp_off
42.42Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
42.31Single5WQCEMPA5WQC-OX2-EMPA
42.31Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
42.31Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
42.31Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
42.31Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
42.31Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
41.94Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
41.94Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
41.94Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
41.94Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
41.94Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
41.94Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
41.38Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
41.38Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
41.38Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
41.38Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
41.18Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
41.18Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
41.18Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
41.18Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
40.74Single2YDVNECA2YDV-A2A-NECA
40.74Single4DJHJDTic4DJH-κ-JDTic
40.74Single4UHRCGS216804UHR-A2A-CGS21680
40.74Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
40.74Single5G53NECA5G53-A2A-NECA-Gs
40.74Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
40.74Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
40.74Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
40.74Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
40.74Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
40.74Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
40.74Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
40.74Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
40.74Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
40.74Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
40.74Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
40.62Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
40.62Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
40.62Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
40.62Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
40.00Single6IGLIRL16206IGL-ETB-IRL1620
40.00Single6IQLL7458706IQL-D4-L745870
40.00Single6V9SGTPL114036V9S-OX1-GTPL11403
40.00Single6ZG9GSK10347026ZG9-M1-GSK1034702
40.00Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
40.00Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
40.00Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
40.00Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
40.00Single8WDTphotoNECA8WDT-A2A-photoNECA
40.00Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
40.00Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
40.00Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
40.00Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
40.00Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
40.00Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
40.00Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
40.00Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
40.00Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
39.39Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
39.39Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
39.39Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
39.39Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
39.29Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
39.29Single6ZG4HTL00099366ZG4-M1-HTL0009936
39.29Single7DFPSpiperone7DFP-D2-Spiperone
39.29Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
39.29Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
39.29Single7K15MKD0467K15-BLT1-MKD046-Na
39.29Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
39.29Single7YITNalfurafine7YIT-κ-Nalfurafine
39.29Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
39.29Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
39.29Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
39.29Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
39.29Single8JWY2-1188JWY-A2A-2-118
39.29Single8JWZAB9288JWZ-A2A-AB928-Na
39.29Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
39.29Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
39.29Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
39.29Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
39.29Consensusalpha1_offOrthosteric Ligandalpha1a_off
39.29Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
39.29Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
39.29Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
39.29Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
38.89Single5GLHEndothelin-15GLH-ETB-Endothelin-1
38.89Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
38.89Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
38.71Single3QAKUK-4320973QAK-A2A-UK-432097
38.71Single6HLOAprepitant6HLO-NK1-Aprepitant
38.71Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
38.71Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
38.71Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
38.71Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
38.71Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
38.71Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
38.71Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
38.71Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
38.71Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
38.46Single3NY8ICI118-5513NY8-β2-ICI118-551
38.46Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
38.46Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
38.46Single4GBRS-Carazolol4GBR-β2-S-Carazolol
38.46Single4YAYZD-71554YAY-AT1-ZD-7155
38.46Single5DHGC-355DHG-NOP-C-35
38.46Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
38.46Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
38.46Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
38.46Single7UL4Alvimopan7UL4-μ-Alvimopan
38.46Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
38.46Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
38.46Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
38.46Single8JJOAlprenolol8JJO-β2-Alprenolol
38.46Single8K5DGSK2560738K5D-HCA2-GSK256073
38.46Single8PJKST1718PJK-5-HT1A-ST171-t7m-Gi1/β1/γ1
38.46Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
38.46Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
38.46Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
38.46Single9CHXS-Carazolol9CHX-β2-S-Carazolol
38.46Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
38.46Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
38.46Consensusdopamine_offOrthosteric Ligandd2_off d3_off
38.46Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
38.46Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
38.46Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
38.46Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
38.46Consensushca_on_gpOrthosteric Ligandhca2_on_gp
37.93Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
37.93Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
37.93Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
37.93Single7EZCUKA7EZC-A2A-UKA
37.93Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
37.93Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
37.93Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
37.93Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
37.93Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
37.93Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
37.93Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
37.93Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
37.93Consensuschemerin_onOrthosteric Ligandcml1_on
37.93Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
37.93Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
37.93Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
37.93Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
37.93Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
37.84Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
37.84Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
37.50Single5WF5UK-4320975WF5-A2A-UK-432097
37.50Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
37.50Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
37.50Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
37.50Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
37.14Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
37.14Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
37.04Single2RH1S-Carazolol2RH1-β2-S-Carazolol
37.04Single2YCWS-Carazolol2YCW-β1-S-Carazolol
37.04Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
37.04Single5D6LS-Carazolol5D6L-β2-S-Carazolol
37.04Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
37.04Single5X7DS-Carazolol5X7D-β2-S-Carazolol-PubChem 129318963
37.04Single5XPRBosentan5XPR-ETB-Bosentan
37.04Single6D26Fevipiprant6D26-DP2-Fevipiprant
37.04Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
37.04Single6PS6Timolol6PS6-β2-Timolol
37.04Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
37.04Single7W41PD1762527W41-BB2-PD176252
37.04Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
37.04Single8S4DCMF-0198S4D-Apelin-CMF-019
37.04Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
37.04Single9F34FOB02-04A9F34-D3-FOB02-04A-Go1/β1/γ2
37.04Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
37.04Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
37.04Consensusamine_offonOrthosteric Ligandamine_off amine_on
37.04Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
37.04Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
37.04Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
37.04Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
37.04Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
37.04Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
37.04Consensusblt_offOrthosteric Ligandblt1_off
37.04Consensusbombesin_offOrthosteric Ligandbb2_off
37.04Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
37.04Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
37.04Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
37.04Consensusdp_offOrthosteric Liganddp2_off
37.04Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
37.04Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
37.04Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
37.04Consensustrace-amine_onOrthosteric Ligandta1_on
36.84Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
36.67Single3NY9ICI118-5513NY9-β2-ICI118-551
36.67Single5ZTYAM102575ZTY-CB2-AM10257
36.67Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
36.67Single7SK9CCX6627SK9-ACKR3-CCX662
36.67Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
36.67Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
36.67Single8X5YAstemizole8X5Y-H1-Astemizole
36.67Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
36.67Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
36.67Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
36.67Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
36.36Single6JODAngiotensin II6JOD-AT2-Angiotensin II
36.36Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
36.36Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
36.36Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
36.11Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
36.11Single8IY6Endothelin-18IY6-ETB-Endothelin-1
36.11Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
36.00Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
36.00Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
36.00Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
36.00Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
36.00Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
36.00Consensusalpha2_offOrthosteric Ligandalpha2c_off
35.71Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
35.71Single5D5AS-Carazolol5D5A-β2-S-Carazolol
35.71Single5D5BS-Carazolol5D5B-β2-S-Carazolol
35.71Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
35.71Single6H7JIsoprenaline6H7J-β1-Isoprenaline
35.71Single6J20Aprepitant6J20-NK1-Aprepitant
35.71Single6J21Aprepitant6J21-NK1-Aprepitant
35.71Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
35.71Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
35.71Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
35.71Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
35.71Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
35.71Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
35.71Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
35.71Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
35.71Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
35.71Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
35.71Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
35.71Single8E0GBU728E0G-μ-BU72
35.71Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
35.71Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
35.71Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
35.71Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
35.71Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
35.71Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
35.71Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
35.71Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
35.71Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
35.71Consensusa2_onOrthosteric Liganda2b_on
35.71Consensusa2_on_gpOrthosteric Liganda2b_on_gp
35.71Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
35.71Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
35.71Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
35.71Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
35.71Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
35.71Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
35.71Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
35.71Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
35.71Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
35.71Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
35.71Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
35.71Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
35.71Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
35.48Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
35.48Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
35.48Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
35.48Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
35.48Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
35.48Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
35.48Consensuslpl_onOrthosteric Ligands1p_on lpa_on
35.48Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
35.29Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
35.29Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
35.29Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
35.29Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
35.29Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
35.29Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
35.29Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
35.14Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
35.14Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
35.14Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
34.62Single2YDOAdenosine2YDO-A2A-Adenosine
34.62Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
34.62Single4ZJCSB-6740424ZJC-OX1-SB-674042
34.62Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
34.62Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
34.62Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
34.62Single6PS0S-Carazolol6PS0-β2-S-Carazolol
34.62Single6PS4ICI118-5516PS4-β2-ICI118-551
34.62Single6TPGEMPA6TPG-OX2-EMPA
34.62Single6TPKRetosiban6TPK-OT-Retosiban
34.62Single6TPNHTL66416TPN-OX2-HTL6641
34.62Single6VI4JDTic6VI4-κ-JDTic
34.62Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
34.62Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
34.62Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
34.62Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
34.62Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
34.62Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
34.62Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
34.62Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
34.62Single8K5CAcipimox8K5C-HCA2-Acipimox
34.62Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
34.62Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
34.62Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
34.62Consensusalpha1_onOrthosteric Ligandalpha1a_on
34.62Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
34.62Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
34.62Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
34.62Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
34.62Consensushca_onOrthosteric Ligandhca2_on
34.62Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
34.62Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
34.62Consensusvasop-oxy_offOrthosteric Ligandot_off
34.48Single3D4STimolol3D4S-β2-Timolol
34.48Single4AMIBucindolol4AMI-β1-Bucindolol
34.48Single4LDEBI1671074LDE-β2-BI167107
34.48Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
34.48Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
34.48Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
34.48Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
34.48Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
34.48Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
34.48Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
34.48Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
34.48Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
34.48Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
34.48Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
34.48Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
34.48Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
34.48Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
34.48Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
34.48Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
34.48Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
34.48Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
34.48Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
34.48Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
34.48Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
34.48Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
34.48Consensuslpl_offOrthosteric Ligands1p_off lpa_off
34.48Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
34.48Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
34.38Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
34.38Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
34.38Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
34.38Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
34.38Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
34.38Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
34.38Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
34.38Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
34.38Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
34.38Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
34.29Single4XT3Fractalkine4XT3-US28-Fractalkine
34.29Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
34.29Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
34.29Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
34.29Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
34.29Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
34.21Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
34.15Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
34.15Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
33.33Single2Y04Salbutamol2Y04-β1-Salbutamol
33.33Single3EMLZM-2413853EML-A2A-ZM-241385
33.33Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
33.33Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
33.33Single4BUONeurotensin4BUO-NTS1-Neurotensin
33.33Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
33.33Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
33.33Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
33.33Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
33.33Single6H7LDobutamine6H7L-β1-Dobutamine
33.33Single6IBLArformoterol6IBL-β1-Arformoterol
33.33Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
33.33Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
33.33Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
33.33Single6PS1Timolol6PS1-β2-Timolol
33.33Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
33.33Single6S0LZM-2413856S0L-A2A-ZM-241385
33.33Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
33.33Single6TOTLemborexant6TOT-OX1-Lemborexant
33.33Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
33.33Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
33.33Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
33.33Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
33.33Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
33.33Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
33.33Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
33.33Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
33.33Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
33.33Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
33.33Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
33.33Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
33.33Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
33.33Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
33.33Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
33.33Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
33.33Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
33.33Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
33.33Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
33.33Single8CU6LJ-45178CU6-A2A-LJ-4517
33.33Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
33.33Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
33.33Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
33.33Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
33.33Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
33.33Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
33.33Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
33.33Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
33.33Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
33.33Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
33.33Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
33.33Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
33.33Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
33.33Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
33.33Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
33.33Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
33.33Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
33.33Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
33.33Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
33.33Single8T1WCVN4248T1W-GPR6-CVN424
33.33Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/β1/γ2
33.33Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
33.33Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
33.33Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
33.33Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
33.33Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
33.33Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
33.33Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
33.33Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
33.33Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
33.33Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
33.33Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
33.33Consensusalpha2_onOrthosteric Ligandalpha2b_on
33.33Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
33.33Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
33.33Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
33.33Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
33.33Consensusangiotensin_onOrthosteric Ligandat1_on
33.33Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
33.33Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
33.33Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
33.33Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
33.33Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
33.33Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
33.33Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
33.33Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
33.33Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
32.50Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
32.43Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
32.43Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
32.43Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
32.43Consensusbradykinin_onOrthosteric Ligandbk2_on
32.43Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
32.43Consensusendothelin_onOrthosteric Ligandetb_on eta_on
32.43Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
32.35Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
32.35Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
32.35Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
32.35Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
32.35Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
32.35Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
32.35Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
32.35Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
32.35Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
32.35Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
32.35Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
32.35Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
32.35Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
32.35Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
32.35Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
32.35Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
32.26Single5WF6UK-4320975WF6-A2A-UK-432097
32.26Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
32.26Single6PT3DPI-2876PT3-δ-DPI-287
32.26Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
32.26Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
32.26Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
32.26Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
32.26Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
32.26Single8QJ2pN1628QJ2-MC4-pN162-Gs
32.26Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
32.26Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
32.26Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
32.14Single2Y03Isoprenaline2Y03-β1-Isoprenaline
32.14Single5C1MBU725C1M-μ-BU72
32.14Single5IUAQ274563485IUA-A2A-Q27456348-Na
32.14Single5JQHS-Carazolol5JQH-β2-S-Carazolol
32.14Single5N2SPSB365N2S-A1-PSB36
32.14Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
32.14Single5WIUNemonapride5WIU-D4-Nemonapride
32.14Single5WIVNemonapride5WIV-D4-Nemonapride-Na
32.14Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
32.14Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
32.14Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
32.14Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
32.14Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
32.14Single6S0QZM-2413856S0Q-A2A-ZM-241385
32.14Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
32.14Single6TP6Filorexant6TP6-OX1-Filorexant
32.14Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
32.14Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
32.14Single7C4SS1P7C4S-S1P3-S1P
32.14Single7C61Ergotamine7C61-5-HT1B-Ergotamine
32.14Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
32.14Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
32.14Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/β1/γ2
32.14Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
32.14Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
32.14Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
32.14Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
32.14Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
32.14Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
32.14Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
32.14Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
32.14Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
32.14Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
32.14Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
32.14Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
32.14Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
32.14Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
32.14Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
32.14Single8GNEKW-63568GNE-A2A-KW-6356-Na
32.14Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
32.14Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
32.14Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
32.14Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
32.14Single8ZMFA1L108ZMF-5-HT2C-A1L10
32.14Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
32.14Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
32.14Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
32.14Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
32.14Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
32.14Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
32.14Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
32.14Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
32.14Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
32.14Consensusadenosine_offOrthosteric Liganda1_off a2_off
32.14Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
32.14Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
32.14Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
32.14Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
32.00Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
32.00Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
32.00Single8K5BNiacin8K5B-HCA2-Niacin
32.00Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
32.00Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
31.58Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
31.58Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
31.43Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
31.43Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
31.43Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
31.43Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
31.43Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
31.43Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
31.43Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
31.43Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
31.25Single4IARErgotamine4IAR-5-HT1B-Ergotamine
31.25Single4XT1Fractalkine4XT1-US28-Fractalkine
31.25Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
31.25Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
31.25Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
31.25Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
31.25Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
31.25Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
31.25Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
31.25Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
31.25Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
31.25Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
31.25Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
31.25Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
31.25Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
31.25Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
31.25Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
31.25Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
31.25Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
31.25Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
31.25Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
31.25Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
31.25Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
31.03Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
31.03Single6E59L-7607356E59-NK1-L-760735
31.03Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
31.03Single7B6WCyclazosin7B6W-α1b-Cyclazosin
31.03Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
31.03Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
31.03Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
31.03Single7TUYGSK682753A7TUY-GPR183-GSK682753A
31.03Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
31.03Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
31.03Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
31.03Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
31.03Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
31.03Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
31.03Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
31.03Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
31.03Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
31.03Single9F33FOB02-04A9F33-D3-FOB02-04A-Go1/β1/γ2
31.03Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
31.03Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
31.03Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
31.03Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
31.03Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
31.03Consensusneurotensin_onOrthosteric Ligandnts1_on
31.03Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
31.03Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
31.03Consensusrelaxin_onOrthosteric Ligandrxfp4_on
31.03Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
31.03Consensustachykinin_offOrthosteric Ligandnk1_off
30.77Single4S0VSuvorexant4S0V-OX2-Suvorexant
30.77Single5WS3EMPA5WS3-OX2-EMPA
30.77Single6B73MP11046B73-κ-MP1104
30.77Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
30.77Single6TODEMPA6TOD-OX1-EMPA-Na
30.77Single6TPJSuvorexant6TPJ-OX2-Suvorexant
30.77Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
30.77Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
30.77Single7XRRLemborexant7XRR-OX2-Lemborexant
30.77Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
30.77Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
30.77Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
30.77Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
30.77Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.77Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
30.77Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
30.77Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
30.77Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
30.77Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
30.77Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
30.77Single8IWESpermidine8IWE-TA9-Spermidine
30.77Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
30.77Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.77Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
30.77Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
30.77Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
30.77Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
30.77Single8Y0HVUF114188Y0H-CXCR3-VUF11418
30.77Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
30.77Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
30.77Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
30.77Consensusangiotensin_offOrthosteric Ligandat1_off
30.77Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
30.77Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
30.77Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
30.77Consensusorexin_offOrthosteric Ligandox2_off ox1_off
30.77Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
30.77Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
30.77Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
30.77Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
30.56Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
30.56Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
30.56Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
30.56Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
30.56Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
30.56Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
30.56Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
30.30Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
30.30Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
30.30Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
30.30Single7XNACYN1548067XNA-SST2-CYN154806
30.30Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
30.30Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
30.30Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
30.30Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
30.30Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
30.30Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
30.00Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
30.00Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
30.00Single4RWADIPP-NH24RWA-δ-DIPP-NH2
30.00Single4XEENeurotensin4XEE-NTS1-Neurotensin
30.00Single4XESNeurotensin4XES-NTS1-Neurotensin
30.00Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
30.00Single6A93Risperidone6A93-5-HT2A-Risperidone
30.00Single6CM4Risperidone6CM4-D2-Risperidone
30.00Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
30.00Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
30.00Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
30.00Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
30.00Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
30.00Single6YVRNTS8-136YVR-NTS1-NTS8-13
30.00Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
30.00Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
30.00Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
30.00Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
30.00Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
30.00Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
30.00Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
30.00Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
30.00Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
30.00Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
30.00Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
30.00Single8JJ8Formoterol8JJ8-β2-Formoterol
30.00Single8JJLOlodaterol8JJL-β2-Olodaterol
30.00Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
30.00Single8XYIVUF106618XYI-CXCR3-VUF10661
30.00Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
30.00Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
30.00Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
30.00Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
30.00Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
30.00Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
30.00Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
30.00Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
30.00Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
30.00Consensuslpa_offOrthosteric Ligandlpa1_off
30.00Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
30.00Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
30.00Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
30.00Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
29.79Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
29.73Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
29.63Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
29.63Single5IU7Q274563465IU7-A2A-Q27456346-Na
29.63Single5JTBZM-2413855JTB-A2A-ZM-241385
29.63Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
29.63Single5UVIZM-2413855UVI-A2A-ZM-241385
29.63Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
29.63Single6PS5S-Propranolol6PS5-β2-S-Propranolol
29.63Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
29.63Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
29.63Single6TP3Nemorexant6TP3-OX1-Nemorexant
29.63Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
29.63Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
29.63Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
29.63Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
29.63Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
29.63Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
29.63Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
29.63Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
29.63Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
29.63Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
29.63Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
29.63Single7T32ZM-2413857T32-A2A-ZM-241385
29.63Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
29.63Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
29.63Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
29.63Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
29.63Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
29.63Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
29.63Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
29.63Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
29.63Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
29.63Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.63Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.63Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
29.63Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
29.63Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
29.63Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
29.63Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
29.63Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
29.63Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
29.63Single8IHKAcifran8IHK-HCA3-Acifran
29.63Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
29.63Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
29.63Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
29.63Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
29.63Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
29.63Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
29.63Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
29.63Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
29.63Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.63Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.63Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.63Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.63Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.63Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
29.63Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
29.63Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
29.63Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
29.63Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
29.63Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
29.63Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
29.63Consensusa2_offOrthosteric Liganda2a_off
29.63Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
29.63Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
29.63Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
29.63Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
29.63Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
29.63Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
29.41Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
29.41Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
29.41Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
29.41Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
29.41Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
29.41Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
29.41Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
29.41Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
29.41Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
29.41Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
29.03Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
29.03Single6K1QIRL25006K1Q-ETB-IRL2500
29.03Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
29.03Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
29.03Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
29.03Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
29.03Single7UM4AS26747237UM4-5-HT5A-AS2674723
29.03Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
29.03Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
29.03Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
29.03Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
29.03Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
29.03Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
29.03Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
29.03Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
29.03Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
28.95Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
28.95Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
28.95Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
28.57Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
28.57Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
28.57Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
28.57Single4EJ4Naltrindole4EJ4-δ-Naltrindole
28.57Single4QKX35V4QKX-β2-35V
28.57Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
28.57Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
28.57Single5IU8Q274563475IU8-A2A-Q27456347-Na
28.57Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
28.57Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
28.57Single5UIGCmpd-15UIG-A2A-Cmpd-1
28.57Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
28.57Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
28.57Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
28.57Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
28.57Single6H7MSalbutamol6H7M-β1-Salbutamol
28.57Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
28.57Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
28.57Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
28.57Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
28.57Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
28.57Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
28.57Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
28.57Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
28.57Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
28.57Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
28.57Single7PYRPSB-21157PYR-A2A-PSB-2115
28.57Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
28.57Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
28.57Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
28.57Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
28.57Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
28.57Single7WC7Lisuride7WC7-5-HT2A-Lisuride
28.57Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
28.57Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
28.57Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
28.57Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
28.57Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
28.57Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
28.57Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
28.57Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
28.57Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
28.57Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
28.57Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
28.57Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
28.57Single8JXRLSD8JXR-D1-LSD
28.57Single8RLNLUF58348RLN-A2A-LUF5834
28.57Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
28.57Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
28.57Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
28.57Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
28.57Single8X63Mepyramine8X63-H1-Mepyramine
28.57Single8X64Desloratadine8X64-H1-Desloratadine
28.57Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
28.57Consensus5ht5_onOrthosteric Ligand5ht5a_on
28.57Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
28.57Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
28.57Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
28.57Consensusa3_onOrthosteric Liganda3a_on
28.57Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
28.57Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
28.57Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
28.57Consensusblt_onOrthosteric Ligandblt1_on
28.57Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
28.57Consensuscck_offOrthosteric Ligandccka_off
28.57Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
28.57Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
28.57Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
28.57Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
28.57Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
28.57Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
28.57Consensushistamine_offOrthosteric Ligandh1_off
28.57Consensusleukotriene_onOrthosteric Ligandblt_on
28.57Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
28.57Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
28.57Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
28.57Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
28.57Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
28.57Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
28.57Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
28.57Consensusvasop-oxy_onOrthosteric Ligandv2_on
28.57Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
28.12Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
28.12Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
28.12Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
28.12Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
28.12Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
28.12Single7XN9L-054,5227XN9-SST2-L-054,522
28.12Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
28.12Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
28.12Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
28.12Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
28.12Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
28.12Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
28.12Consensuskisspeptin_onOrthosteric Ligandkiss1_on
28.12Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
28.00Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
28.00Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
28.00Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
27.78Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
27.78Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
27.78Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
27.78Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
27.78Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
27.78Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
27.78Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
27.78Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
27.78Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
27.78Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
27.78Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
27.59Single2Y00Dobutamine2Y00-β1-Dobutamine
27.59Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
27.59Single5N2RPSB-365N2R-A2A-PSB-36-Na
27.59Single5TVNLSD5TVN-5-HT2B-LSD
27.59Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
27.59Single6E67BI1671076E67-β2-BI167107-Gs (fused)
27.59Single6HLPNetupitant6HLP-NK1-Netupitant
27.59Single6LUQHaloperidol6LUQ-D2-Haloperidol
27.59Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
27.59Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
27.59Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
27.59Single7SINNPS-21437SIN-CaS-NPS-2143
27.59Single7SINNPS-21437SIN-CaS-NPS-2143
27.59Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
27.59Single7WC6LSD7WC6-5-HT2A-LSD
27.59Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
27.59Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
27.59Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
27.59Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
27.59Single8JXSPF-61428JXS-D1-PF-6142
27.59Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
27.59Single8QOTNanobody-E8QOT-μ-Nanobody-E
27.59Single8WGBW9R8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
27.59Single8XYKVUF106618XYK-CXCR3-VUF10661-Go1/β1/γ2
27.59Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
27.59Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
27.59Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
27.59Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
27.59Consensusa3_on_gpOrthosteric Liganda3a_on_gp
27.59Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
27.59Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
27.59Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
27.59Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
27.59Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
27.59Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
27.59Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
27.59Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
27.59Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
27.59Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
27.59Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
27.59Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
27.50Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
27.27Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
27.27Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
27.27Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
27.27Single7QA8Peptide7QA8-STE2-Peptide
27.27Single7QA8Peptide7QA8-STE2-Peptide
27.27Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
27.27Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
27.27Single8WKYPG-9348WKY-MC4-PG-934
27.27Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
27.27Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
27.27Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
27.27Consensussomatostatin_offOrthosteric Ligandsst2_off
27.03Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
27.03Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
27.03Single7SK3CXCL127SK3-ACKR3-CXCL12
27.03Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
27.03Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
27.03Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
26.92Single3OE9IT1t3OE9-CXCR4-IT1t
26.92Single3PBLEticlopride3PBL-D3-Eticlopride
26.92Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
26.92Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
26.92Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
26.92Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
26.92Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
26.92Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
26.92Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
26.92Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
26.92Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go1/β1/γ2
26.92Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
26.92Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
26.92Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
26.92Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
26.92Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
26.92Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
26.67Single3P0GBI1671073P0G-β2-BI167107
26.67Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
26.67Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
26.67Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
26.67Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
26.67Single4U15Tiotropium4U15-M3-Tiotropium
26.67Single5V54Methiothepin5V54-5-HT1B-Methiothepin
26.67Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
26.67Single6OL9Tiotropium6OL9-M5-Tiotropium
26.67Single6WGTLSD6WGT-5-HT2A-LSD
26.67Single7FEECP559407FEE-CB1-CP55940-ZCZ011
26.67Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
26.67Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
26.67Single7PX4PSB-21137PX4-A2A-PSB-2113
26.67Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
26.67Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
26.67Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
26.67Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
26.67Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
26.67Single8EA0Iperoxo8EA0-M3-Iperoxo
26.67Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
26.67Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
26.67Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
26.67Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
26.67Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
26.67Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
26.67Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
26.67Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
26.67Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
26.67Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
26.67Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
26.67Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
26.67Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
26.67Consensus5ht1_offOrthosteric Ligand5ht1b_off
26.67Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
26.67Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
26.67Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
26.67Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
26.67Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
26.67Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
26.47Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
26.32Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
26.32Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
26.32Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
26.32Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
26.32Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
26.19Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
26.19Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
26.19Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
25.93Single3ODUIT1t3ODU-CXCR4-IT1t
25.93Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
25.93Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
25.93Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
25.93Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
25.93Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
25.93Single6AKXA4R6AKX-CCR5-A4R
25.93Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
25.93Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
25.93Single6ME2Ramelteon6ME2-MT1-Ramelteon
25.93Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
25.93Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
25.93Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
25.93Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
25.93Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
25.93Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
25.93Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
25.93Single7F8ULintitript7F8U-CCKA-Lintitript
25.93Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
25.93Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
25.93Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
25.93Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
25.93Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
25.93Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
25.93Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
25.93Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
25.93Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
25.93Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
25.93Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
25.93Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
25.93Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
25.93Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
25.93Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.93Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
25.93Single8GNGIstradefylline8GNG-A2A-Istradefylline
25.93Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
25.93Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
25.93Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
25.93Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
25.93Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
25.93Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
25.93Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
25.93Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.93Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.93Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
25.93Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ
25.93Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
25.93Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
25.93Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
25.93Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
25.93Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
25.93Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
25.93Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
25.93Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
25.93Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
25.93Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
25.81Single5CXVTiotropium5CXV-M1-Tiotropium
25.81Single5X33BIIL2605X33-BLT1-BIIL260
25.81Single6KQICP559406KQI-CB1-CP55940-Org27569
25.81Single6MXTSalmeterol6MXT-β2-Salmeterol
25.81Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
25.81Single6OS2TRV0266OS2-AT1-TRV026
25.81Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
25.81Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
25.81Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
25.81Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
25.81Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
25.81Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
25.81Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
25.81Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.81Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
25.81Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
25.81Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
25.81Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
25.81Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
25.81Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
25.81Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
25.81Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
25.81Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
25.81Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
25.81Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
25.71Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
25.71Single6W25SHU91196W25-MC4-SHU9119-Ca
25.71Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
25.71Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
25.71Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
25.71Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
25.71Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
25.71Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
25.64Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
25.64Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
25.64Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
25.64Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
25.64Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
25.64Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
25.00Single3REYXAC3REY-A2A-XAC
25.00Single3RZECidoxepin3RZE-H1-Cidoxepin
25.00Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
25.00Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
25.00Single4MBSMaraviroc4MBS-CCR5-Maraviroc
25.00Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
25.00Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
25.00Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
25.00Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
25.00Single5IUBQ274563445IUB-A2A-Q27456344-Na
25.00Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
25.00Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
25.00Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
25.00Single6A94Zotepine6A94-5-HT2A-Zotepine
25.00Single6AQFZM-2413856AQF-A2A-ZM-241385
25.00Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
25.00Single6KUXRS-799486KUX-α2a-RS-79948
25.00Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
25.00Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
25.00Single6MH8ZM-2413856MH8-A2A-ZM-241385
25.00Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
25.00Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
25.00Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
25.00Single7AROLUF58337ARO-A2A-LUF5833-Na
25.00Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
25.00Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
25.00Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
25.00Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
25.00Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
25.00Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
25.00Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
25.00Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
25.00Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
25.00Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
25.00Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
25.00Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
25.00Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-PubChem 118610427-chim(NtGi1-Go)/β1/γ2
25.00Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
25.00Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
25.00Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
25.00Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
25.00Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
25.00Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
25.00Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
25.00Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
25.00Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
25.00Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
25.00Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
25.00Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
25.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
25.00Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
25.00Single8XVJMacitentan8XVJ-ETA-Macitentan
25.00Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
25.00Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single8YN8Proxyfan8YN8-H3-Proxyfan-Go1/β1/γ2
25.00Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
25.00Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
25.00Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single9BJKNaloxone9BJK-μ-Naloxone-NAM
25.00Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
25.00Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
25.00Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
25.00Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
25.00Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Consensusopsins_offOrthosteric Ligandrhodopsin_off
25.00Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
25.00Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
25.00Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
25.00Consensussensory_offOrthosteric Ligandopsins_off
24.39Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
24.39Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
24.39Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
24.32Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
24.32Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
24.32Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
24.32Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
24.24Single5EE7MK08935EE7-Glucagon-MK0893
24.24Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
24.24Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
24.24Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
24.24Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
24.14Single2Y01Dobutamine2Y01-β1-Dobutamine
24.14Single2Y02Carmoterol2Y02-β1-Carmoterol
24.14Single4DAJTiotropium4DAJ-M3-Tiotropium
24.14Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
24.14Single4MQSIperoxo4MQS-M2-Iperoxo
24.14Single4U14Tiotropium4U14-M3-Tiotropium
24.14Single5DSGTiotropium5DSG-M4-Tiotropium
24.14Single5T04Neurotensin5T04-NTS1-Neurotensin
24.14Single5TGZAM65385TGZ-CB1-AM6538
24.14Single6D27CAY104716D27-DP2-CAY10471
24.14Single6DRXLisuride6DRX-5-HT2B-Lisuride
24.14Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
24.14Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
24.14Single7BU7BI1671077BU7-β1-BI167107
24.14Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
24.14Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
24.14Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
24.14Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
24.14Single7V3ZCP559407V3Z-CB1-CP55940
24.14Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
24.14Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
24.14Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
24.14Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
24.14Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
24.14Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
24.14Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
24.14Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
24.14Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
24.14Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
24.14Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
24.14Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
24.14Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
24.14Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
24.14Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
24.14Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
24.14Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
24.14Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
24.14Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
24.14Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
24.00Single3OE8IT1t3OE8-CXCR4-IT1t
24.00Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
24.00Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
24.00Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
24.00Single9CHUNoradrenaline9CHU-β2-Noradrenaline
23.81Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
23.81Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
23.68Single6FJ3PTH6FJ3-PTH1-PTH
23.68Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
23.68Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
23.68Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
23.68Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
23.68Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
23.53Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
23.53Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/β1/γ2
23.53Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
23.33Single5CGCHTL142425CGC-mGlu5-HTL14242
23.33Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
23.33Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
23.33Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
23.33Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
23.33Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
23.33Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
23.33Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
23.33Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
23.33Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
23.33Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
23.33Single8TF5Oleic acid8TF5-GPR6-Oleic acid
23.33Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
23.33Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
23.33Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
23.33Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
23.33Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
23.33Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
23.33Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
23.33Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
23.08Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
23.08Single3OE6IT1t3OE6-CXCR4-IT1t
23.08Single3UZAGTPL92363UZA-A2A-GTPL9236
23.08Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
23.08Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
23.08Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
23.08Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
23.08Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
23.08Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
23.08Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
23.08Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
23.08Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
23.08Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
23.08Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
23.08Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
23.08Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
23.08Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
23.08Consensus5ht2_onOrthosteric Ligand5ht2b_on
23.08Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.08Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
23.08Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
23.08Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
22.86Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
22.86Single7SK5CXCL127SK5-ACKR3-CXCL12
22.86Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
22.86Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
22.86Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
22.58Single4BV0Neurotensin4BV0-NTS1-Neurotensin
22.58Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
22.58Single5XR8AM8415XR8-CB1-AM841
22.58Single5XRAAM115425XRA-CB1-AM11542
22.58Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
22.58Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
22.58Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
22.58Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
22.58Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
22.58Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
22.58Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
22.58Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
22.58Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
22.58Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
22.58Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
22.58Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.58Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
22.58Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
22.58Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
22.58Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
22.58Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
22.58Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
22.58Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
22.58Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
22.58Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
22.58Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
22.58Consensuslpa_onOrthosteric Ligandlpa1_on
22.58Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
22.58Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
22.58Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
22.58Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
22.58Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
22.58Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
22.50Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
22.50Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
22.50Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
22.22Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
22.22Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
22.22Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
22.22Single3OE0CVX153OE0-CXCR4-CVX15
22.22Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
22.22Single6HLLCP999946HLL-NK1-CP99994
22.22Single6TP4ACT-4622066TP4-OX1-ACT-462206
22.22Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
22.22Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
22.22Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
22.22Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
22.22Single7SRQLSD7SRQ-5-HT2B-LSD
22.22Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
22.22Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
22.22Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.22Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
22.22Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
22.22Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
22.22Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
22.22Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
22.22Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
22.22Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
22.22Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
22.22Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
22.22Single8YN7Immethridine8YN7-H3-Immethridine-Go1/β1/γ2
22.22Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
22.22Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
22.22Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
22.22Consensusgq_nucleotideOrthosteric Ligandgq_p2y
22.22Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
22.22Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
22.22Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
22.22Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
22.22Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
21.95Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
21.95Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
21.88Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
21.88Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
21.88Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
21.88Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
21.88Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
21.88Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
21.88Single8ZPLHF511168ZPL-CXCR4-HF51116-Cholesterol
21.62Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
21.62Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
21.62Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
21.62Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
21.62Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
21.62Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
21.43Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
21.43Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
21.43Single3PWHZM-2413853PWH-A2A-ZM-241385
21.43Single4BWBNeurotensin4BWB-NTS1-Neurotensin
21.43Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
21.43Single6AKYMaraviroc6AKY-CCR5-Maraviroc
21.43Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
21.43Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
21.43Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
21.43Single7F8YDevazepide7F8Y-CCKA-Devazepide
21.43Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
21.43Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.43Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
21.43Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
21.43Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
21.43Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
21.43Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
21.43Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
21.43Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
21.43Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
21.43Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
21.43Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
21.43Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
21.43Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
21.43Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
21.43Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.43Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
21.43Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
21.43Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
21.43Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
21.28Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
21.21Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
21.21Single5CGDHTL142425CGD-mGlu5-HTL14242
21.21Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
21.21Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
21.21Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
21.21Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
21.21Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
21.21Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(CtGi1-G13)/β1/γ2
21.05Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
21.05Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
21.05Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
20.93Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
20.93Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
20.83Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
20.69Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
20.69Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
20.69Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
20.69Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
20.69Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
20.69Single7UL3Famotidine7UL3-H2-Famotidine
20.69Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
20.69Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
20.69Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
20.69Single8K9LDamgo8K9L-μ-Damgo-VV9-Gi3/β1/γ1
20.69Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
20.69Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.69Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
20.69Single8ZPMAMD0708ZPM-CXCR4-AMD070-Cholesterol
20.69Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
20.69Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
20.69Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
20.69Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
20.59Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
20.59Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
20.59Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.59Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
20.59Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
20.59Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
20.59Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
20.51Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
20.45Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
20.00Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
20.00Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
20.00Single5UENDU1725UEN-A1-DU172
20.00Single6GPSMK08126GPS-CCR2-MK0812
20.00Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
20.00Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
20.00Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
20.00Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
20.00Single7F83PF-051904577F83-Ghrelin-PF-05190457
20.00Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
20.00Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
20.00Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
20.00Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
20.00Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
20.00Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
20.00Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
20.00Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
20.00Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
20.00Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
20.00Single8IEBA1LYA8IEB-GPR156-A1LYA
20.00Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
20.00Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
20.00Single8KIGSHU91198KIG-MC3-SHU9119-Ca
20.00Single8PWNTheophylline8PWN-A2A-Theophylline
20.00Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
20.00Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
20.00Single9IYAONO-97105319IYA-GPR55-ONO-9710531
20.00Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
20.00Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
19.51Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
19.51Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
19.51Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
19.51Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
19.51Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
19.44Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
19.44Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
19.44Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
19.44Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
19.35Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
19.35Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
19.35Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
19.35Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
19.35Single6GPXMK08126GPX-CCR2-MK0812
19.35Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
19.35Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
19.35Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
19.35Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
19.35Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
19.35Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
19.35Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
19.35Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
19.35Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
19.35Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
19.35Consensusep_offOrthosteric Ligandep4_off
19.35Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
19.35Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
19.35Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
19.35Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
19.35Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
19.23Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
19.23Single6TQ9SB-4081246TQ9-OX1-SB-408124
19.23Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
19.23Single8A2OTheophylline8A2O-A2A-Theophylline-Na
19.23Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
19.23Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
19.23Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
19.23Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
19.23Consensussensory_onOrthosteric Ligandopsins_on
19.05Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/β1/γ2
18.92Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
18.92Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
18.75Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
18.75Single6OS1TRV0266OS1-AT1-TRV026
18.75Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
18.75Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
18.75Single7R0CAVP7R0C-V2-AVP-Arrestin2
18.75Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
18.75Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
18.75Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
18.75Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
18.75Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
18.75Single9BJKNAM9BJK-μ-Naloxone-NAM
18.75Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
18.75Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
18.60Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
18.52Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
18.52Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
18.52Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
18.52Single6ME5Agomelatine6ME5-MT1-Agomelatine
18.52Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
18.52Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
18.52Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
18.52Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
18.52Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
18.52Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.52Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
18.52Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
18.52Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
18.52Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
18.52Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
18.52Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
18.52Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
18.52Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
18.52Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
18.52Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
18.52Consensusgi_sensoryOrthosteric Ligandgi_opsins
18.52Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
18.52Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
18.52Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
18.52Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
18.52Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
18.42Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
18.42Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
18.42Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
18.42Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ22
18.42Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
18.18Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
18.18Single4N4WSANT-14N4W-SMO-SANT-1
18.18Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
18.18Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
18.18Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
18.18Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
18.18Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
18.18Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
18.18Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
18.18Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
18.18Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
18.18Single8XJNCloprosetnol8XJN-TP-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
17.95Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
17.95Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
17.86Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
17.86Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
17.86Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
17.86Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
17.86Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
17.86Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
17.86Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
17.86Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
17.86Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
17.86Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
17.86Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.86Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.86Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
17.86Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
17.65Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
17.65Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
17.65Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
17.65Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
17.65Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
17.65Consensusfp-alpha_onOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
17.65Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
17.65Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
17.65Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
17.65Consensustp_onOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
17.65Consensustp_on_gpOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
17.50Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
17.50Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
17.39Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
17.24Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
17.24Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
17.24Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
17.24Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
17.24Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
17.24Single5ZKQABT-4915ZKQ-PAF-ABT-491
17.24Single6DS0Ly2660976DS0-5-HT2B-Ly266097
17.24Single6ME9Ramelteon6ME9-MT2-Ramelteon
17.24Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.24Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
17.24Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
17.24Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
17.24Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
17.24Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
17.24Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
17.24Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
17.24Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.24Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
17.24Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
17.14Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
17.14Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
17.14Single8XQJJN2418XQJ-Apelin-JN241
17.14Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
17.07Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
16.67Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
16.67Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
16.67Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
16.67Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
16.67Single7VODCariprazine7VOD-5-HT2A-Cariprazine
16.67Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
16.67Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
16.67Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
16.67Single8IEIA1LYA8IEI-GPR156-A1LYA
16.67Single8IEPA1LYA8IEP-GPR156-A1LYA
16.67Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
16.67Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
16.67Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
16.67Single8ZPNAMD31008ZPN-CXCR4-AMD3100-Cholesterol
16.67Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
16.67Consensusgrh_offOrthosteric Ligandgnrh1_off
16.22Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
16.22Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
16.22Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
16.13Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
16.13Single6IIVDaltroban6IIV-TP-Daltroban
16.13Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/β1/γ2
16.13Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
16.13Single7YXAONO-54306087YXA-S1P5-ONO-5430608
16.13Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
16.13Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
16.00Single5MZPCaffeine5MZP-A2A-Caffeine-Na
16.00Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
16.00Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
16.00Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
15.91Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
15.79Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.79Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
15.79Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
15.62Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
15.62Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
15.62Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
15.62Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
15.62Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
15.62Single6Z4SSR486926Z4S-NTS1-SR48692
15.62Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
15.62Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
15.62Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.62Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
15.62Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
15.62Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
15.62Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
15.62Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
15.62Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
15.38Single3PXOAll-trans-Retinal3PXO-Rhodopsin-All-trans-Retinal
15.38Single5DYSAll-trans-Retinal5DYS-Rhodopsin-All-trans-Retinal
15.38Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
15.38Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
15.38Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
15.22Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
15.22Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
15.15Single5TZRMK86665TZR-FFA1-MK8666
15.15Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
15.15Single7P2L4YI7P2L-mGlu5-4YI
15.15Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
15.15Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
15.15Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
15.15Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
15.15Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
15.15Single9GE2ML1849GE2-GPR55-ML184-Cholesterol-chim(CtGi1-G13)/β1/γ2
15.15Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
15.00Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
15.00Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
14.81Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
14.81Single3RFMCaffeine3RFM-A2A-Caffeine
14.81Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
14.81Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
14.81Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
14.71Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
14.71Single5TZYMK8666; PubChem 1270535975TZY-FFA1-MK8666; PubChem 127053597
14.71Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
14.71Single6IIURamatroban6IIU-TP-Ramatroban
14.71Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
14.71Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.71Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
14.71Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
14.71Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
14.71Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
14.29Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
14.29Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
14.29Single7V6A-7V6A-M4-PubChem 9864275-Gi1/β1/γ2
14.29Single7WC5Psilocin7WC5-5-HT2A-Psilocin
14.29Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
14.29Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
14.29Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
14.29Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
14.29Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
14.29Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
13.95Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
13.89Single6KNMJN241-96KNM-Apelin-JN241-9
13.89Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
13.89Single8IEIA1LYA8IEI-GPR156-A1LYA
13.89Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
13.89Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
13.89Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
13.89Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
13.79Single5L7IVismodegib5L7I-SMO-Vismodegib
13.79Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
13.79Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
13.79Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
13.79Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
13.79Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
13.79Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
13.79Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
13.79Single8YRGFospropofol8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
13.79Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
13.79Single9B9Y7DY9B9Y-CB1-7DY
13.79Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
13.51Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
13.51Single8IEPA1LYA8IEP-GPR156-A1LYA
13.51Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
13.51Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
13.51Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
13.51Single8XWNCXCL88XWN-CXCR2-CXCL8
13.33Single5U09Taranabant5U09-CB1-Taranabant
13.33Single7BR3Elagolix7BR3-GnRH1-Elagolix
13.33Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
13.33Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
13.33Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
13.33Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/β1/γ2
13.33Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
13.16Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
13.16Single8IEBA1LYA8IEB-GPR156-A1LYA
13.16Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
12.90Single6FFIMMPEP6FFI-mGlu5-MMPEP
12.90Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
12.90Single6ZINSR486926ZIN-NTS1-SR48692
12.90Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
12.90Single8K2WAMG4878K2W-CXCR3-AMG487
12.90Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
12.90Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
12.90Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
12.77Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
12.50Single6FFHFenobam6FFH-mGlu5-Fenobam
12.50Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
12.50Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
12.50Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
12.50Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
12.50Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
12.50Single9B9ZA1AKO9B9Z-CB1-A1AKO
12.20Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
12.12Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
12.12Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
12.12Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
12.12Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
12.12Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
12.12Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
12.12Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
11.76Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
11.76Single5V56TC1145V56-SMO-TC114
11.76Single7F1TMIP-1a7F1T-CCR5-MIP-1a
11.76Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
11.76Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
11.76Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
11.76Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
11.76Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
11.76Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
11.76Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
11.54Single4A4MAll-trans-Retinal4A4M-Rhodopsin-All-trans-Retinal-Gt(CT)
11.54Single5EN0All-trans-Retinal5EN0-Rhodopsin-All-trans-Retinal-Gt(CT)
11.43Single4PY02MeSATP4PY0-P2Y12-2MeSATP
11.43Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
11.43Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
11.43Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
11.43Single8XQJJN2418XQJ-Apelin-JN241
11.43Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
11.43Single8XWSCXCL58XWS-CXCR2-CXCL5
11.43Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
11.43Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
11.11Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
11.11Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
11.11Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
11.11Single7WC4Serotonin7WC4-5-HT2A-Serotonin
11.11Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
11.11Single8XVUCXCL28XVU-CXCR2-CXCL2
11.11Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
11.11Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
10.81Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
10.81Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
10.81Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
10.53Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
10.53Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
10.53Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
10.34Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
10.34Single4XNWMRS25004XNW-P2Y1-MRS2500
10.34Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
10.34Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.34Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
10.34Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
10.34Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
10.34Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
10.34Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
10.34Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
10.00Single4O9RCyclopamine4O9R-SMO-Cyclopamine
10.00Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
10.00Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
10.00Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
10.00Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
9.68Single4QINSAG1.54QIN-SMO-SAG1.5
9.68Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
9.68Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
9.68Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
9.68Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
9.68Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
9.68Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.68Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
9.68Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
9.68Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.68Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.68Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
9.68Single9BA0A1AKN9BA0-CB1-A1AKN
9.68Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
9.68Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
9.38Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
9.38Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
9.38Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
9.38Single7VV6C48/807VV6-MRGPRX2-C48/80
9.38Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
9.38Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
9.38Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
9.38Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
9.38Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Cholesterol-Gi1/β1/γ2
9.09Single4QIMANTA XV4QIM-SMO-ANTA XV
9.09Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
9.09Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
9.09Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
9.09Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
9.09Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
9.09Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
9.09Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
8.82Single4JKVTaladegib4JKV-SMO-Taladegib
8.82Single4NTJAZD12834NTJ-P2Y12-AZD1283
8.82Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
8.82Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
8.82Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
8.57Single5V57TC1145V57-SMO-TC114
8.57Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
8.57Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
8.57Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
8.57Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
8.33Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
8.33Single8XWACXCL18XWA-CXCR2-CXCL1
8.33Single8XWMCXCL68XWM-CXCR2-CXCL6
8.11Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
8.11Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
8.11Single8XWFCXCL38XWF-CXCR2-CXCL3
8.11Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
7.89Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
7.89Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
7.41Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
7.14Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
6.90Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
6.90Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
6.90Consensusp2y_offOrthosteric Ligandp2y1_off
6.67Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
6.67Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
6.45Single6LI0C176LI0-GPR52-C17
6.45Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.45Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
6.45Single7UL2SR486927UL2-NTS1-SR48692-Na
6.45Single8HSCFab0468HSC-GPR20-Fab046-Gi1/β1/γ2
6.45Consensusneurotensin_offOrthosteric Ligandnts1_off
6.45Consensusnts1_offOrthosteric Ligand7UL2-NTS1-SR48692-Na
6.25Single7VVOPTH7VVO-PTH1-PTH-Gs/β1/γ2
6.25Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
6.25Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
5.88Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
5.88Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
5.88Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
5.71Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
5.71Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
5.71Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
5.56Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Cholesterol-Gi1/β1/γ1
5.41Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
4.88Single7SHEPI; PE7SHE-GPR158-PI; PE
3.70Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
3.70Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
3.57Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/β1/γ2
3.45Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
3.45Single8HS2Fab0468HS2-GPR20-Fab046
3.45Single9GE2Cholesterol9GE2-GPR55-ML184-Cholesterol-chim(CtGi1-G13)/β1/γ2
3.33Single7Y14Beta-Alanine7Y14-MRGPRD-β-Alanine
3.33Single8IKGQ2B8IKG-CB1-Q2B-Gi1/β1/γ1
3.33Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/β1/γ2
3.23Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
3.23Single7Y12Beta-Alanine7Y12-MRGPRD-β-Alanine-Gi1/β1/γ2
3.23Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
3.23Single8JPSCCL78JPS-ACKR1-CCL7
3.12Single7FEEZCZ0117FEE-CB1-CP55940-ZCZ011
3.12Single8IKHQ2L8IKH-CB1-Q2L-Gi1/β1/γ1
3.12Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
3.12Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
3.12Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
3.03Single4K5YCP-3763954K5Y-CRF1-CP-376395
3.03Single4XNVBPTU4XNV-P2Y1-BPTU
3.03Single7WV9ZCZ0117WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
3.03Single8G94CD698G94-S1P1-CD69-Gi1/β1/γ2
3.03Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
3.03Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
2.94Single8IYXYL-3658IYX-GPR34-YL-365
2.94Single8JD6N-(3-chlorophenyl)pyridine-2-carboxamide8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
2.86Single4Z9GCP-3763954Z9G-CRF1-CP-376395
2.86Single8GTIBMK-C2058GTI-CRF1-BMK-C205
2.78Single8GTGBMK-I1528GTG-CRF1-BMK-I152
2.70Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
2.63Single7SHEPI; PE7SHE-GPR158-PI; PE
2.63Single8GTMBMK-C2038GTM-CRF1-BMK-C203
2.56Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
2.38Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7

Consensus Members
Id Members
7W40 7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
7W3Z 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
Net Summary
Imin 2.845
Number of Linked Nodes 985
Number of Links 1252
Number of Hubs 218
Number of Links mediated by Hubs 794
Number of Communities 24
Number of Nodes involved in Communities 300
Number of Links involved in Communities 477
Path Summary
Number Of Nodes in MetaPath 110
Number Of Links MetaPath 109
Number of Shortest Paths 8150138
Length Of Smallest Path 3
Average Path Length 41.2917
Length of Longest Path 71
Minimum Path Strength 1.0175
Average Path Strength 6.40043
Maximum Path Strength 42.02
Minimum Path Correlation 0.7
Average Path Correlation 0.994273
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.66667
Average % Of Corr. Nodes 37.012
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 54.6705
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following consensuses:
IdComponents
gq_peptidegq_cck
gq_kisspeptin
gq_bradykinin
gq_bombesin
gq_angiotensin



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Download gq_bombesin.zip



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