psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	A:A:D9	A:A:L5	2.71	No	No	0	4	2
2	A:A:K10	A:A:L5	2.82	No	No	0	3	2
3	A:A:D9	A:A:S6	2.94	No	No	0	4	7
4	A:A:K17	A:A:V13	4.55	No	No	0	4	3
5	A:A:I19	A:A:R15	3.76	No	No	0	9	5
6	A:A:R15	B:B:H91	3.39	No	No	0	5	5
7	A:A:D20	A:A:S16	2.94	No	No	21	6	7
8	A:A:S16	B:B:N88	4.47	No	No	0	7	7
9	A:A:S16	B:B:K89	3.06	No	Yes	21	7	9
10	A:A:M18	A:A:R21	6.2	No	No	0	4	4
11	A:A:I19	B:B:K89	5.82	No	Yes	0	9	9
12	A:A:I19	B:B:A92	3.25	No	No	0	9	6
13	A:A:D20	B:B:K89	13.83	No	Yes	21	6	9
14	A:A:L23	B:B:K78	4.23	No	No	0	6	8
15	A:A:L23	B:B:I80	2.85	No	No	0	6	8
16	A:A:D26	A:A:E25	2.6	No	No	0	5	4
17	A:A:E25	A:A:K29	2.7	No	No	0	4	1
18	A:A:D26	B:B:K78	8.3	No	No	0	5	8
19	A:A:R32	R:R:R226	11.73	No	No	0	4	4
20	A:A:E33	A:A:H195	7.39	No	No	0	6	4
21	A:A:E33	A:A:K197	13.5	No	Yes	0	6	7
22	A:A:L194	A:A:V34	4.47	No	No	13	3	5
23	A:A:F196	A:A:V34	7.87	Yes	No	13	4	5
24	A:A:T219	A:A:V34	4.76	No	No	0	9	5
25	A:A:K197	A:A:K35	8.62	Yes	No	1	7	9
26	A:A:F199	A:A:K35	7.44	Yes	No	1	7	9
27	A:A:K35	A:A:V218	3.04	No	No	0	9	5
28	A:A:F196	A:A:L36	4.87	Yes	Yes	13	4	7
29	A:A:I222	A:A:L36	2.85	No	Yes	0	8	7
30	A:A:L36	A:A:V339	2.98	Yes	No	13	7	6
31	A:A:F215	A:A:L37	7.31	Yes	No	0	7	9
32	A:A:K46	A:A:L38	4.23	No	Yes	22	9	8
33	A:A:L38	A:A:M198	11.31	Yes	No	0	8	6
34	A:A:D200	A:A:L38	5.43	Yes	Yes	22	5	8
35	A:A:I222	A:A:L38	5.71	No	Yes	0	8	8
36	A:A:L39	A:A:R208	3.64	No	No	0	9	9
37	A:A:I221	A:A:L39	2.85	No	No	0	8	9
38	A:A:I253	A:A:L39	7.14	No	No	0	7	9
39	A:A:A41	A:A:S44	3.42	No	No	0	7	9
40	A:A:E43	A:A:R242	8.14	No	Yes	0	9	9
41	A:A:A226	A:A:S44	3.42	No	No	0	7	9
42	A:A:D200	A:A:K46	8.3	Yes	No	22	5	9
43	A:A:I49	A:A:Q52	4.12	No	No	7	9	9
44	A:A:I49	A:A:N331	2.83	No	Yes	7	9	4
45	A:A:K51	A:A:V50	4.55	No	No	0	6	7
46	A:A:N331	A:A:Q52	5.28	Yes	No	7	4	9
47	A:A:F189	A:A:M53	4.98	No	No	0	3	9
48	A:A:M53	A:A:V332	4.56	No	No	0	9	8
49	A:A:F189	A:A:K54	2.48	No	No	0	3	8
50	A:A:G183	A:A:T182	3.64	No	No	0	7	9
51	A:A:F199	A:A:I184	3.77	Yes	Yes	1	7	9
52	A:A:I184	A:A:V201	4.61	Yes	No	1	9	9
53	A:A:F215	A:A:I184	2.51	Yes	Yes	1	7	9
54	A:A:I184	B:B:W99	8.22	Yes	Yes	1	9	9
55	A:A:E186	A:A:F199	4.66	No	Yes	1	5	7
56	A:A:E186	B:B:W99	6.54	No	Yes	1	5	9
57	A:A:F189	A:A:T187	3.89	No	No	0	3	9
58	A:A:H188	A:A:K197	13.1	No	Yes	0	6	7
59	A:A:H195	A:A:T190	5.48	No	No	0	4	9
60	A:A:F191	A:A:K192	11.17	Yes	No	24	3	5
61	A:A:F191	A:A:V332	10.49	Yes	No	0	3	8
62	A:A:F191	A:A:Q333	3.51	Yes	No	0	3	7
63	A:A:F191	A:A:F336	9.65	Yes	Yes	24	3	8
64	A:A:F336	A:A:K192	19.85	Yes	No	24	8	5
65	A:A:F196	A:A:L194	2.44	Yes	No	13	4	3
66	A:A:F196	A:A:V339	5.24	Yes	No	13	4	6
67	A:A:F199	A:A:K197	6.2	Yes	Yes	1	7	7
68	A:A:F199	A:A:F215	4.29	Yes	Yes	1	7	7
69	A:A:F199	B:B:W99	11.02	Yes	Yes	1	7	9
70	A:A:D200	A:A:G202	5.03	Yes	No	0	5	9
71	A:A:V201	A:A:W211	8.58	No	Yes	1	9	9
72	A:A:F215	A:A:V201	2.62	Yes	No	1	7	9
73	A:A:Q204	A:A:S206	2.89	Yes	Yes	1	9	9
74	A:A:Q204	B:B:L117	5.32	Yes	No	0	9	9
75	A:A:Q204	B:B:Y145	3.38	Yes	Yes	1	9	8
76	A:A:S206	A:A:W211	2.47	Yes	Yes	1	9	9
77	A:A:S206	B:B:Y145	5.09	Yes	Yes	1	9	8
78	A:A:S206	B:B:D186	2.94	Yes	Yes	1	9	9
79	A:A:E207	A:A:K209	16.2	Yes	No	0	8	9
80	A:A:E207	A:A:K210	8.1	Yes	Yes	1	8	8
81	A:A:E207	B:B:D186	7.8	Yes	Yes	1	8	9
82	A:A:E207	B:B:C204	3.04	Yes	Yes	1	8	7
83	A:A:R208	A:A:W211	10	No	Yes	0	9	9
84	A:A:I212	A:A:R208	2.51	No	No	0	9	9
85	A:A:K210	B:B:Y145	3.58	Yes	Yes	1	8	8
86	A:A:K210	B:B:M188	11.52	Yes	Yes	1	8	8
87	A:A:K210	B:B:C204	4.85	Yes	Yes	1	8	7
88	A:A:K210	B:B:D228	9.68	Yes	Yes	1	8	9
89	A:A:F215	A:A:W211	4.01	Yes	Yes	1	7	9
90	A:A:F259	A:A:I212	5.02	Yes	No	0	5	9
91	A:A:H213	A:A:W258	9.52	No	Yes	0	8	4
92	A:A:C214	B:B:Y59	2.69	No	Yes	1	8	8
93	A:A:C214	B:B:Q75	7.63	No	No	1	8	9
94	A:A:C214	B:B:W99	2.61	No	Yes	1	8	9
95	A:A:F215	A:A:V218	2.62	Yes	No	0	7	5
96	A:A:F215	B:B:W99	5.01	Yes	Yes	1	7	9
97	A:A:E216	A:A:W258	8.72	No	Yes	0	9	4
98	A:A:E216	B:B:K57	5.4	No	No	0	9	9
99	A:A:F259	A:A:I221	8.79	Yes	No	23	5	8
100	A:A:I221	A:A:T262	4.56	No	No	23	8	4
101	A:A:F267	A:A:I222	2.51	Yes	No	0	9	8
102	A:A:F223	A:A:V225	2.62	Yes	No	0	7	7
103	A:A:F223	A:A:L249	6.09	Yes	No	0	7	5
104	A:A:F223	A:A:F250	17.15	Yes	Yes	5	7	9
105	A:A:F223	A:A:L266	2.44	Yes	Yes	5	7	8
106	A:A:C224	A:A:F267	5.59	No	Yes	0	9	9
107	A:A:A226	A:A:D229	3.09	No	Yes	0	7	9
108	A:A:L227	A:A:L268	9.69	No	Yes	0	8	9
109	A:A:I303	A:A:L227	2.85	No	No	0	6	8
110	A:A:D229	A:A:R242	20.25	Yes	Yes	0	9	9
111	A:A:D229	A:A:M243	5.54	Yes	Yes	0	9	9
112	A:A:F274	A:A:Y230	6.19	No	Yes	0	6	8
113	A:A:K277	A:A:Y230	8.36	No	Yes	0	5	8
114	A:A:P282	A:A:Y230	2.78	No	Yes	0	7	8
115	A:A:D231	A:A:K277	6.91	No	No	0	8	5
116	A:A:L232	A:A:N241	5.49	No	Yes	0	9	6
117	A:A:L232	A:A:R242	10.93	No	Yes	0	9	9
118	A:A:N241	A:A:V233	4.43	Yes	No	0	6	8
119	A:A:M243	A:A:N241	4.21	Yes	Yes	0	9	6
120	A:A:H244	A:A:N241	2.55	No	Yes	0	8	6
121	A:A:F307	A:A:M247	4.98	Yes	No	0	5	9
122	A:A:I253	A:A:L249	4.28	No	No	0	7	5
123	A:A:C254	A:A:F250	4.19	Yes	Yes	5	8	9
124	A:A:F250	A:A:I264	2.51	Yes	No	5	9	7
125	A:A:F250	A:A:L266	3.65	Yes	Yes	5	9	8
126	A:A:F250	A:A:I319	2.51	Yes	No	0	9	4
127	A:A:D251	A:A:L310	16.29	No	No	0	9	4
128	A:A:C254	A:A:N255	3.15	Yes	No	0	8	5
129	A:A:C254	A:A:I264	3.27	Yes	No	5	8	7
130	A:A:C254	A:A:N311	4.72	Yes	Yes	5	8	4
131	A:A:C254	A:A:K317	3.23	Yes	Yes	5	8	3
132	A:A:K312	A:A:N255	12.59	No	No	0	8	5
133	A:A:F259	A:A:N256	6.04	Yes	No	0	5	8
134	A:A:K257	A:A:W258	9.28	No	Yes	0	8	4
135	A:A:W258	B:B:R314	3	Yes	Yes	1	4	8
136	A:A:W258	B:B:W332	4.69	Yes	Yes	1	4	9
137	A:A:F259	A:A:T262	9.08	Yes	No	23	5	4
138	A:A:D261	A:A:T260	10.12	No	No	0	3	9
139	A:A:R313	A:A:T260	7.76	No	No	0	5	9
140	A:A:D261	A:A:T316	7.23	No	No	0	3	3
141	A:A:S263	A:A:Y320	3.82	No	Yes	0	7	5
142	A:A:S263	A:A:V342	4.85	No	No	0	7	8
143	A:A:I264	A:A:K317	5.82	No	Yes	5	7	3
144	A:A:F267	A:A:I265	3.77	Yes	Yes	0	9	6
145	A:A:I265	A:A:Y320	2.42	Yes	Yes	0	6	5
146	A:A:F334	A:A:I265	2.51	No	Yes	0	5	6
147	A:A:L266	A:A:L268	5.54	Yes	Yes	5	8	9
148	A:A:F307	A:A:L266	3.65	Yes	Yes	5	5	8
149	A:A:L266	A:A:T321	4.42	Yes	No	0	8	7
150	A:A:F267	A:A:H322	6.79	Yes	Yes	7	9	5
151	A:A:F267	A:A:T324	2.59	Yes	Yes	7	9	4
152	A:A:F307	A:A:L268	2.44	Yes	Yes	5	5	9
153	A:A:F323	A:A:L268	2.44	No	Yes	0	9	9
154	A:A:N269	A:A:T324	5.85	No	Yes	0	8	4
155	A:A:F323	A:A:K271	8.69	No	No	0	9	9
156	A:A:C325	A:A:K271	6.47	No	No	0	9	9
157	A:A:F274	A:A:Y296	4.13	No	No	0	6	5
158	A:A:E275	A:A:Y296	10.1	No	No	0	9	5
159	A:A:I285	A:A:P282	3.39	No	No	0	4	7
160	A:A:C286	A:A:Y287	4.03	No	No	0	3	6
161	A:A:Y287	A:A:Y290	3.97	No	Yes	0	6	6
162	A:A:G292	A:A:Y290	4.35	No	Yes	0	3	6
163	A:A:Y290	A:A:Y302	6.95	Yes	No	0	6	3
164	A:A:S293	A:A:T295	4.8	No	No	25	7	3
165	A:A:E298	A:A:S293	10.06	No	No	25	4	7
166	A:A:N294	A:A:T295	2.92	No	No	0	3	3
167	A:A:E298	A:A:T295	12.7	No	No	25	4	3
168	A:A:E297	A:A:E298	2.54	No	No	0	4	4
169	A:A:Q306	A:A:Y302	18.04	No	No	0	3	3
170	A:A:F307	A:A:I303	7.54	Yes	No	0	5	6
171	A:A:Q304	A:A:T321	15.59	No	No	0	7	7
172	A:A:F323	A:A:Q304	7.03	No	No	0	9	7
173	A:A:E308	A:A:I319	10.93	No	No	0	8	4
174	A:A:D309	A:A:L310	4.07	No	No	0	3	4
175	A:A:K317	A:A:N311	2.8	Yes	Yes	5	3	4
176	A:A:I319	A:A:N311	4.25	No	Yes	0	4	4
177	A:A:K317	A:A:R313	2.48	Yes	No	0	3	5
178	A:A:D315	A:A:T316	5.78	No	No	0	3	3
179	A:A:K317	A:A:T316	3	Yes	No	0	3	3
180	A:A:E318	A:A:Y320	10.1	No	Yes	0	7	5
181	A:A:E318	A:A:K345	4.05	No	No	0	7	6
182	A:A:D341	A:A:Y320	3.45	Yes	Yes	0	6	5
183	A:A:H322	A:A:T324	5.48	Yes	Yes	7	5	4
184	A:A:H322	A:A:N331	5.1	Yes	Yes	7	5	4
185	A:A:F334	A:A:H322	16.97	No	Yes	0	5	5
186	A:A:D328	A:A:T324	4.34	Yes	Yes	7	8	4
187	A:A:N331	A:A:T324	5.85	Yes	Yes	7	4	4
188	A:A:C325	A:A:D328	10.89	No	Yes	0	9	8
189	A:A:D328	A:A:K330	2.77	Yes	No	0	8	9
190	A:A:D328	A:A:N331	6.73	Yes	Yes	7	8	4
191	A:A:F336	A:A:T340	5.19	Yes	No	0	8	8
192	A:A:D337	R:R:R311	14.29	No	No	0	8	5
193	A:A:I344	A:A:T340	3.04	No	No	0	7	8
194	A:A:D341	A:A:K345	12.44	Yes	No	0	6	6
195	A:A:D341	R:R:H304	6.3	Yes	Yes	4	6	7
196	A:A:D341	R:R:M308	5.54	Yes	No	4	6	7
197	A:A:N346	A:A:V342	2.96	No	No	0	5	8
198	A:A:I343	R:R:L222	2.85	No	No	0	7	7
199	A:A:I343	R:R:K225	2.91	No	No	0	7	4
200	A:A:I344	R:R:P221	3.39	No	No	0	7	8
201	A:A:I344	R:R:H304	2.65	No	Yes	0	7	7
202	A:A:N347	R:R:Y224	11.63	No	Yes	0	4	7
203	A:A:N347	R:R:K225	6.99	No	No	0	4	4
204	A:A:L348	A:A:L353	2.77	Yes	Yes	4	8	8
205	A:A:F354	A:A:L348	7.31	Yes	Yes	4	7	8
206	A:A:L348	R:R:I218	2.85	Yes	Yes	0	8	9
207	A:A:L348	R:R:M337	2.83	Yes	No	4	8	6
208	A:A:L348	R:R:L341	2.77	Yes	Yes	4	8	8
209	A:A:F354	A:A:K349	2.48	Yes	No	0	7	9
210	A:A:D350	R:R:R150	3.57	No	Yes	0	5	5
211	A:A:C351	A:A:L353	3.17	Yes	Yes	4	4	8
212	A:A:C351	R:R:R214	5.57	Yes	Yes	4	4	9
213	A:A:C351	R:R:S217	6.89	Yes	No	0	4	8
214	A:A:L353	R:R:R214	9.72	Yes	Yes	4	8	9
215	A:A:L353	R:R:L341	2.77	Yes	Yes	4	8	8
216	A:A:F354	R:R:M337	3.73	Yes	No	4	7	6
217	A:A:F354	R:R:R340	7.48	Yes	No	0	7	7
218	A:A:F354	R:R:L341	6.09	Yes	Yes	4	7	8
219	B:B:L4	B:B:R8	10.93	No	No	0	4	3
220	B:B:L7	B:B:R8	2.43	No	No	0	8	3
221	B:B:E10	B:B:Q13	5.1	No	Yes	14	8	1
222	B:B:E10	B:B:L14	3.98	No	Yes	14	8	8
223	B:B:L14	B:B:Q13	3.99	Yes	Yes	14	8	1
224	B:B:Q13	B:B:Q17	2.56	Yes	Yes	14	1	4
225	B:B:K15	G:G:L19	4.23	No	No	0	6	9
226	B:B:I18	B:B:Q17	4.12	No	Yes	0	7	4
227	B:B:D20	B:B:R19	5.96	No	No	0	2	4
228	B:B:L30	B:B:T34	2.95	Yes	No	0	5	5
229	B:B:L261	B:B:L30	6.92	No	Yes	0	5	5
230	B:B:L30	B:B:M262	4.24	Yes	No	0	5	4
231	B:B:L30	G:G:A34	6.3	Yes	No	0	5	6
232	B:B:N35	B:B:N36	9.54	No	No	0	1	1
233	B:B:D38	B:B:I37	4.2	No	No	0	1	2
234	B:B:I37	B:B:K301	2.91	No	Yes	0	2	5
235	B:B:I43	B:B:V40	3.07	No	Yes	0	3	3
236	B:B:R283	B:B:V40	7.85	Yes	Yes	18	9	3
237	B:B:D298	B:B:V40	7.3	No	Yes	18	9	3
238	B:B:Q44	B:B:R42	3.5	No	No	0	4	2
239	B:B:I43	B:B:L284	2.85	No	No	0	3	5
240	B:B:L308	B:B:M45	8.48	No	No	0	7	4
241	B:B:M45	G:G:L50	4.24	No	No	0	4	9
242	B:B:K337	B:B:T47	4.5	Yes	No	9	6	3
243	B:B:T47	B:B:W339	8.49	No	Yes	9	3	9
244	B:B:N340	B:B:R48	4.82	No	No	0	9	7
245	B:B:I338	B:B:R49	8.77	No	No	3	5	7
246	B:B:R49	G:G:F61	7.48	No	Yes	3	7	8
247	B:B:R52	B:B:T50	7.76	No	No	0	7	3
248	B:B:K337	B:B:T50	4.5	Yes	No	0	6	3
249	B:B:L51	B:B:W82	22.78	Yes	Yes	0	9	9
250	B:B:L336	B:B:L51	4.15	No	Yes	0	7	9
251	B:B:I338	B:B:L51	4.28	No	Yes	0	5	9
252	B:B:H54	B:B:I58	5.3	Yes	Yes	15	9	9
253	B:B:H54	B:B:S74	6.97	Yes	Yes	15	9	9
254	B:B:D76	B:B:H54	5.04	Yes	Yes	15	9	9
255	B:B:H54	B:B:I80	11.93	Yes	No	0	9	8
256	B:B:H54	B:B:S334	2.79	Yes	No	0	9	4
257	B:B:A56	B:B:S74	3.42	No	Yes	15	7	9
258	B:B:A56	B:B:D76	6.18	No	Yes	15	7	9
259	B:B:K57	B:B:Y59	3.58	No	Yes	1	9	8
260	B:B:K57	B:B:W332	23.21	No	Yes	1	9	9
261	B:B:I58	B:B:S74	6.19	Yes	Yes	15	9	9
262	B:B:G330	B:B:I58	3.53	No	Yes	0	5	9
263	B:B:I58	B:B:L336	2.85	Yes	No	0	9	7
264	B:B:Q75	B:B:Y59	6.76	No	Yes	1	9	8
265	B:B:W332	B:B:Y59	5.79	Yes	Yes	1	9	8
266	B:B:A60	B:B:C103	3.61	No	No	0	7	8
267	B:B:L70	B:B:M61	2.83	Yes	Yes	0	5	6
268	B:B:C317	B:B:M61	8.1	No	Yes	0	7	6
269	B:B:A328	B:B:M61	3.22	No	Yes	0	5	6
270	B:B:L336	B:B:M61	4.24	No	Yes	0	7	6
271	B:B:H62	B:B:Y105	3.27	No	Yes	0	6	6
272	B:B:H62	B:B:R150	13.54	No	Yes	0	6	6
273	B:B:L70	B:B:W63	9.11	Yes	Yes	3	5	7
274	B:B:S84	B:B:W63	4.94	Yes	Yes	3	5	7
275	B:B:G319	B:B:W63	2.81	No	Yes	0	5	7
276	B:B:T321	B:B:W63	12.13	Yes	Yes	3	7	7
277	B:B:A326	B:B:W63	2.59	No	Yes	0	7	7
278	B:B:A328	B:B:W63	5.19	No	Yes	0	5	7
279	B:B:G64	B:B:Y105	4.35	No	Yes	0	5	6
280	B:B:D66	B:B:R68	3.57	No	Yes	0	8	5
281	B:B:D66	B:B:L69	9.5	No	No	0	8	5
282	B:B:S67	B:B:T321	4.8	No	Yes	3	5	7
283	B:B:D322	B:B:S67	4.42	No	No	0	1	5
284	B:B:D323	B:B:S67	10.31	No	No	3	7	5
285	B:B:D83	B:B:R68	5.96	No	Yes	0	8	5
286	B:B:R68	B:B:S84	2.64	Yes	Yes	0	5	5
287	B:B:R68	B:B:Y85	25.72	Yes	No	0	5	4
288	B:B:L69	B:B:Y105	5.86	No	Yes	0	5	6
289	B:B:L70	B:B:W82	3.42	Yes	Yes	0	5	9
290	B:B:L70	B:B:S84	3	Yes	Yes	3	5	5
291	B:B:L79	B:B:V71	2.98	Yes	Yes	0	7	8
292	B:B:I81	B:B:V71	3.07	No	Yes	0	7	8
293	B:B:C103	B:B:V71	3.42	No	Yes	0	8	8
294	B:B:V71	B:B:Y105	3.79	Yes	Yes	0	8	6
295	B:B:S72	B:B:W82	4.94	No	Yes	0	9	9
296	B:B:D76	B:B:S74	5.89	Yes	Yes	15	9	9
297	B:B:Q75	B:B:W99	7.67	No	Yes	1	9	9
298	B:B:D76	B:B:K78	4.15	Yes	No	0	9	8
299	B:B:G77	B:B:L95	3.42	No	Yes	0	8	8
300	B:B:I93	B:B:L79	2.85	Yes	Yes	0	7	7
301	B:B:L79	B:B:L95	5.54	Yes	Yes	0	7	8
302	B:B:C114	B:B:L79	3.17	No	Yes	0	8	7
303	B:B:I80	B:B:W82	12.92	No	Yes	0	8	9
304	B:B:I81	B:B:V90	6.14	No	No	0	7	5
305	B:B:K89	B:B:W82	9.28	Yes	Yes	0	9	9
306	B:B:D83	B:B:T86	4.34	No	No	0	8	6
307	B:B:S84	G:G:F61	5.28	Yes	Yes	3	5	8
308	B:B:Y85	G:G:P60	4.17	No	Yes	3	4	9
309	B:B:Y85	G:G:F61	5.16	No	Yes	3	4	8
310	B:B:N88	B:B:T86	7.31	No	No	0	7	6
311	B:B:H91	B:B:V133	6.92	No	Yes	0	5	4
312	B:B:I93	B:B:P94	3.39	Yes	No	0	7	5
313	B:B:I93	B:B:Y124	4.84	Yes	Yes	10	7	6
314	B:B:I93	B:B:V133	6.14	Yes	Yes	10	7	4
315	B:B:L95	B:B:V100	4.47	Yes	No	0	8	9
316	B:B:L95	B:B:Y124	5.86	Yes	Yes	0	8	6
317	B:B:R96	B:B:V135	2.62	No	No	0	6	4
318	B:B:S97	B:B:W99	3.71	No	Yes	0	8	9
319	B:B:D118	B:B:S97	8.83	No	No	0	9	8
320	B:B:L117	B:B:W99	5.69	No	Yes	0	9	9
321	B:B:L117	B:B:M101	2.83	No	No	0	9	9
322	B:B:C149	B:B:T102	5.07	No	No	0	8	8
323	B:B:A104	B:B:F151	2.77	No	Yes	0	7	9
324	B:B:V112	B:B:Y105	2.52	No	Yes	10	8	6
325	B:B:L126	B:B:Y105	3.52	No	Yes	10	5	6
326	B:B:A106	B:B:F151	4.16	No	Yes	0	6	9
327	B:B:N110	B:B:S108	7.45	No	No	0	4	6
328	B:B:D154	B:B:S108	2.94	No	No	0	6	6
329	B:B:N110	B:B:Y111	4.65	No	Yes	0	4	4
330	B:B:K127	B:B:N110	6.99	No	No	0	4	4
331	B:B:I123	B:B:Y111	3.63	Yes	Yes	11	6	4
332	B:B:N125	B:B:Y111	15.12	No	Yes	11	4	4
333	B:B:S136	B:B:Y111	2.54	No	Yes	11	4	4
334	B:B:D154	B:B:Y111	5.75	No	Yes	0	6	4
335	B:B:V112	B:B:Y124	3.79	No	Yes	10	8	6
336	B:B:L126	B:B:V112	2.98	No	No	10	5	8
337	B:B:A113	B:B:F151	4.16	No	Yes	0	9	9
338	B:B:C114	B:B:Y124	6.72	No	Yes	0	8	6
339	B:B:D118	B:B:I120	8.4	No	No	0	9	6
340	B:B:H142	B:B:N119	2.55	Yes	No	0	9	9
341	B:B:G144	B:B:N119	5.09	No	No	0	8	9
342	B:B:E138	B:B:I120	6.83	No	No	0	6	6
343	B:B:A140	B:B:I120	3.25	No	No	0	5	6
344	B:B:C121	B:B:L139	4.76	No	No	0	8	9
345	B:B:S122	B:B:Y124	3.82	No	Yes	0	8	6
346	B:B:E138	B:B:S122	4.31	No	No	0	6	8
347	B:B:I123	B:B:S136	3.1	Yes	No	11	6	4
348	B:B:F151	B:B:I123	3.77	Yes	Yes	0	9	6
349	B:B:I123	B:B:I171	2.94	Yes	Yes	0	6	6
350	B:B:V133	B:B:Y124	3.79	Yes	Yes	10	4	6
351	B:B:V135	B:B:Y124	5.05	No	Yes	0	4	6
352	B:B:N125	B:B:T128	5.85	No	No	11	4	3
353	B:B:N125	B:B:R134	7.23	No	No	11	4	3
354	B:B:L126	B:B:V133	2.98	No	Yes	10	5	4
355	B:B:R134	B:B:T128	3.88	No	No	11	3	3
356	B:B:R134	B:B:S136	2.64	No	No	11	3	4
357	B:B:I171	B:B:R137	2.51	Yes	No	0	6	5
358	B:B:L139	B:B:W169	12.53	No	Yes	0	9	8
359	B:B:H142	B:B:L146	3.86	Yes	No	1	9	7
360	B:B:H142	B:B:T159	5.48	Yes	Yes	1	9	9
361	B:B:H142	B:B:S161	13.95	Yes	No	1	9	9
362	B:B:D163	B:B:H142	7.56	Yes	Yes	1	9	9
363	B:B:H142	B:B:T165	2.74	Yes	No	1	9	7
364	B:B:A167	B:B:H142	4.39	No	Yes	1	4	9
365	B:B:H142	B:B:Q176	2.47	Yes	Yes	1	9	4
366	B:B:D163	B:B:T143	4.34	Yes	No	0	9	5
367	B:B:S147	B:B:Y145	3.82	No	Yes	0	9	8
368	B:B:G162	B:B:Y145	4.35	No	Yes	1	9	8
369	B:B:D186	B:B:Y145	6.9	Yes	Yes	1	9	8
370	B:B:M188	B:B:Y145	3.59	Yes	Yes	1	8	8
371	B:B:L146	B:B:T159	2.95	No	Yes	1	7	9
372	B:B:C148	B:B:R150	6.96	No	Yes	12	6	6
373	B:B:C148	B:B:L190	3.17	No	Yes	12	6	5
374	B:B:C149	B:B:T159	5.07	No	Yes	0	8	9
375	B:B:L190	B:B:R150	2.43	Yes	Yes	12	5	6
376	B:B:L192	B:B:R150	3.64	No	Yes	12	5	6
377	B:B:L152	B:B:Q156	9.32	No	No	0	3	5
378	B:B:L152	B:B:L192	4.15	No	No	12	3	5
379	B:B:L152	B:B:T196	4.42	No	No	12	3	1
380	B:B:D170	B:B:N155	8.08	No	No	28	9	3
381	B:B:I171	B:B:N155	5.66	Yes	No	0	6	3
382	B:B:E172	B:B:N155	3.94	No	No	28	6	3
383	B:B:L168	B:B:Q156	3.99	Yes	No	0	6	5
384	B:B:I157	B:B:W169	3.52	No	Yes	0	7	8
385	B:B:I157	B:B:I171	2.94	No	Yes	0	7	6
386	B:B:L168	B:B:V158	4.47	Yes	No	0	6	5
387	B:B:F199	B:B:V158	9.18	Yes	No	0	9	5
388	B:B:T159	B:B:W169	9.7	Yes	Yes	1	9	8
389	B:B:S160	B:B:V187	4.85	No	No	0	6	9
390	B:B:L190	B:B:S160	9.01	Yes	No	0	5	6
391	B:B:D163	B:B:S161	5.89	Yes	No	1	9	9
392	B:B:D186	B:B:G162	3.35	Yes	No	1	9	9
393	B:B:D163	B:B:T165	11.56	Yes	No	1	9	7
394	B:B:T164	B:B:T184	7.85	No	No	0	6	3
395	B:B:T165	B:B:T181	4.71	No	No	0	7	2
396	B:B:C166	B:B:F180	4.19	No	Yes	0	8	7
397	B:B:C166	B:B:F199	5.59	No	Yes	0	8	9
398	B:B:C166	B:B:S201	3.44	No	No	0	8	9
399	B:B:A167	B:B:W169	5.19	No	Yes	1	4	8
400	B:B:A167	B:B:Q176	6.06	No	Yes	1	4	4
401	B:B:L168	B:B:T177	4.42	Yes	No	8	6	4
402	B:B:L168	B:B:T178	4.42	Yes	No	8	6	4
403	B:B:F180	B:B:L168	2.44	Yes	Yes	8	7	6
404	B:B:Q176	B:B:W169	14.24	Yes	Yes	1	4	8
405	B:B:D170	B:B:E172	3.9	No	No	28	9	6
406	B:B:D170	B:B:T173	4.34	No	No	0	9	5
407	B:B:Q176	B:B:T179	5.67	Yes	No	0	4	4
408	B:B:T177	B:B:T178	3.14	No	No	8	4	4
409	B:B:F180	B:B:T178	6.49	Yes	No	8	7	4
410	B:B:F180	B:B:W211	15.03	Yes	Yes	8	7	8
411	B:B:F180	B:B:G216	3.01	Yes	No	0	7	4
412	B:B:G182	B:B:K209	3.49	No	Yes	0	6	6
413	B:B:G185	B:B:T184	3.64	No	No	0	5	3
414	B:B:C204	B:B:D186	7.78	Yes	Yes	1	7	9
415	B:B:S201	B:B:V187	3.23	No	No	0	9	9
416	B:B:C204	B:B:M188	3.24	Yes	Yes	1	7	8
417	B:B:M188	B:B:N230	4.21	Yes	No	0	8	9
418	B:B:I232	B:B:S189	6.19	Yes	No	0	8	7
419	B:B:F199	B:B:L190	9.74	Yes	Yes	0	9	5
420	B:B:F234	B:B:S191	9.25	No	No	0	5	8
421	B:B:L192	B:B:T196	2.95	No	No	12	5	1
422	B:B:A193	B:B:F234	2.77	No	No	0	4	5
423	B:B:D195	B:B:P194	3.22	No	No	0	5	4
424	B:B:G238	B:B:P194	4.06	No	No	0	7	4
425	B:B:D195	B:B:R197	4.76	No	No	0	5	5
426	B:B:R197	B:B:R214	4.26	No	No	0	5	9
427	B:B:L198	B:B:L210	6.92	No	No	0	3	5
428	B:B:F199	B:B:W211	9.02	Yes	Yes	0	9	8
429	B:B:F199	B:B:V213	2.62	Yes	No	0	9	4
430	B:B:I232	B:B:V200	4.61	Yes	No	2	8	6
431	B:B:F234	B:B:V200	6.55	No	No	0	5	6
432	B:B:F241	B:B:V200	2.62	Yes	No	2	6	6
433	B:B:S201	B:B:W211	6.18	No	Yes	0	9	8
434	B:B:A203	B:B:D205	3.09	No	No	0	8	9
435	B:B:C204	B:B:D228	6.22	Yes	Yes	1	7	9
436	B:B:D205	B:B:S207	10.31	No	No	0	9	5
437	B:B:K209	B:B:W211	8.12	Yes	Yes	8	6	8
438	B:B:C218	B:B:K209	8.08	No	Yes	8	5	6
439	B:B:K209	B:B:T221	7.51	Yes	No	0	6	7
440	B:B:L210	B:B:Q220	5.32	No	No	0	5	7
441	B:B:L210	B:B:L255	8.3	No	No	0	5	6
442	B:B:C218	B:B:W211	5.22	No	Yes	8	5	8
443	B:B:D212	B:B:E215	6.5	No	Yes	19	9	3
444	B:B:D212	B:B:R219	17.87	No	No	19	9	5
445	B:B:E215	B:B:M217	8.12	Yes	No	19	3	3
446	B:B:E215	B:B:R219	3.49	Yes	No	19	3	5
447	B:B:M217	B:B:R219	6.2	No	No	19	3	5
448	B:B:F222	B:B:Q220	5.86	Yes	No	2	8	7
449	B:B:D258	B:B:Q220	13.05	No	No	2	7	7
450	B:B:T221	G:G:E22	8.47	No	No	0	7	9
451	B:B:F222	B:B:F241	9.65	Yes	Yes	2	8	6
452	B:B:F222	B:B:L255	2.44	Yes	No	2	8	6
453	B:B:D258	B:B:F222	5.97	No	Yes	2	7	8
454	B:B:E226	B:B:G224	4.91	Yes	No	0	3	6
455	B:B:E226	B:B:S245	2.87	Yes	No	2	3	9
456	B:B:D247	B:B:E226	9.09	No	Yes	2	9	3
457	B:B:E226	B:B:R251	9.3	Yes	Yes	2	3	8
458	B:B:D228	B:B:S227	5.89	Yes	No	1	9	6
459	B:B:D246	B:B:S227	2.94	No	No	1	9	6
460	B:B:D228	B:B:D246	11.98	Yes	No	1	9	9
461	B:B:I229	B:B:S245	7.74	No	No	0	7	9
462	B:B:D246	B:B:N230	9.42	No	No	0	9	9
463	B:B:A231	B:B:V276	3.39	No	No	0	5	6
464	B:B:F241	B:B:I232	5.02	Yes	Yes	2	6	8
465	B:B:I232	B:B:T243	4.56	Yes	Yes	2	8	8
466	B:B:C233	B:B:V276	3.42	No	No	0	3	6
467	B:B:C233	B:B:F278	4.19	No	Yes	0	3	7
468	B:B:F235	B:B:P236	15.89	Yes	Yes	6	6	7
469	B:B:F235	B:B:N237	2.42	Yes	Yes	6	6	5
470	B:B:F235	B:B:F278	7.5	Yes	Yes	6	6	7
471	B:B:F235	B:B:G282	6.02	Yes	No	6	6	9
472	B:B:F235	G:G:L37	10.96	Yes	No	6	6	7
473	B:B:F235	G:G:Y40	5.16	Yes	Yes	6	6	6
474	B:B:F278	B:B:P236	2.89	Yes	Yes	6	7	7
475	B:B:G282	B:B:P236	4.06	No	Yes	6	9	7
476	B:B:P236	G:G:Y40	5.56	Yes	Yes	6	7	6
477	B:B:N237	B:B:N239	6.81	Yes	No	0	5	2
478	B:B:N237	G:G:L37	2.75	Yes	No	6	5	7
479	B:B:N237	G:G:Y40	10.47	Yes	Yes	6	5	6
480	B:B:N239	B:B:R256	8.44	No	No	0	2	9
481	B:B:A240	B:B:D254	3.09	No	No	0	6	9
482	B:B:F241	B:B:T243	2.59	Yes	Yes	2	6	8
483	B:B:F241	B:B:F253	8.57	Yes	Yes	2	6	6
484	B:B:F241	B:B:L255	2.44	Yes	No	2	6	6
485	B:B:A242	B:B:F278	2.77	No	Yes	6	4	7
486	B:B:A242	B:B:L285	3.15	No	Yes	6	4	6
487	B:B:F253	B:B:T243	5.19	Yes	Yes	2	6	8
488	B:B:G244	B:B:I273	3.53	No	No	0	5	6
489	B:B:D247	B:B:S245	5.89	No	No	2	9	9
490	B:B:D247	B:B:T249	8.67	No	No	0	9	6
491	B:B:R251	B:B:T249	9.06	Yes	No	0	8	6
492	B:B:C250	B:B:Y264	6.72	No	Yes	0	8	5
493	B:B:F253	B:B:R251	3.21	Yes	Yes	2	6	8
494	B:B:E260	B:B:R251	18.61	No	Yes	2	6	8
495	B:B:R251	B:B:T263	3.88	Yes	No	2	8	1
496	B:B:L252	B:B:Y264	3.52	No	Yes	0	7	5
497	B:B:E260	B:B:F253	3.5	No	Yes	2	6	6
498	B:B:A257	B:B:D254	4.63	No	No	0	7	9
499	B:B:D254	G:G:A33	4.63	No	No	0	9	7
500	B:B:R256	G:G:I28	3.76	No	No	0	9	4
501	B:B:R256	G:G:D36	5.96	No	No	0	9	5
502	B:B:A257	G:G:V30	3.39	No	No	0	7	8
503	B:B:D258	G:G:R27	8.34	No	No	0	7	8
504	B:B:E260	B:B:T263	4.23	No	No	2	6	1
505	B:B:M262	B:B:Y264	7.18	No	Yes	0	4	5
506	B:B:S265	B:B:T263	3.2	No	No	0	2	1
507	B:B:L285	B:B:Y264	3.52	Yes	Yes	0	6	5
508	B:B:W297	B:B:Y264	4.82	Yes	Yes	0	8	5
509	B:B:H266	B:B:N268	10.2	No	No	1	4	4
510	B:B:H266	B:B:I269	2.65	No	Yes	1	4	4
511	B:B:I269	B:B:N268	9.91	Yes	No	1	4	4
512	B:B:C271	B:B:I269	3.27	Yes	Yes	1	5	4
513	B:B:I269	B:B:Y289	3.63	Yes	Yes	1	4	7
514	B:B:C271	B:B:Y289	2.69	Yes	Yes	1	5	7
515	B:B:C271	B:B:D290	6.22	Yes	Yes	1	5	6
516	B:B:C271	B:B:D291	7.78	Yes	No	0	5	8
517	B:B:D290	B:B:G272	3.35	Yes	No	0	6	4
518	B:B:I273	B:B:Y289	12.09	No	Yes	0	6	7
519	B:B:D290	B:B:T274	4.34	Yes	No	1	6	8
520	B:B:R314	B:B:T274	2.59	Yes	No	1	8	8
521	B:B:L318	B:B:S277	6.01	No	No	0	6	5
522	B:B:F278	B:B:L285	7.31	Yes	Yes	6	7	6
523	B:B:S279	B:B:V320	3.23	No	No	0	9	7
524	B:B:S279	G:G:L50	4.5	No	No	0	9	9
525	B:B:S281	G:G:C41	3.44	No	No	0	9	7
526	B:B:S281	G:G:H44	2.79	No	No	0	9	6
527	B:B:S281	G:G:D48	4.42	No	No	0	9	9
528	B:B:D298	B:B:R283	15.48	No	Yes	18	9	9
529	B:B:K301	B:B:R283	9.9	Yes	Yes	18	5	9
530	B:B:R283	G:G:C41	4.18	Yes	No	0	9	7
531	B:B:R283	G:G:L51	2.43	Yes	Yes	0	9	6
532	B:B:L284	B:B:V296	5.96	No	Yes	0	5	5
533	B:B:L284	G:G:L51	2.77	No	Yes	0	5	6
534	B:B:L286	B:B:V296	5.96	No	Yes	0	7	5
535	B:B:L286	B:B:L318	2.77	No	No	0	7	6
536	B:B:L286	B:B:V327	4.47	No	No	0	7	6
537	B:B:A287	B:B:Y289	2.67	No	Yes	1	6	7
538	B:B:A287	B:B:W297	2.59	No	Yes	1	6	8
539	B:B:C294	B:B:G288	3.92	No	No	0	5	7
540	B:B:N295	B:B:Y289	5.81	Yes	Yes	1	6	7
541	B:B:W297	B:B:Y289	9.65	Yes	Yes	1	8	7
542	B:B:D290	B:B:R314	13.1	Yes	Yes	1	6	8
543	B:B:D291	B:B:N293	2.69	No	No	0	8	5
544	B:B:F292	B:B:N313	3.62	No	No	0	4	7
545	B:B:N293	B:B:N295	4.09	No	Yes	0	5	6
546	B:B:N293	B:B:V307	2.96	No	No	0	5	3
547	B:B:C294	B:B:V315	5.12	No	No	0	5	7
548	B:B:N295	B:B:W297	6.78	Yes	Yes	1	6	8
549	B:B:N295	B:B:R304	7.23	Yes	No	1	6	5
550	B:B:L308	B:B:V296	2.98	No	Yes	0	7	5
551	B:B:R304	B:B:W297	6	No	Yes	1	5	8
552	B:B:D298	B:B:K301	13.83	No	Yes	18	9	5
553	B:B:K301	B:B:L300	2.82	Yes	Yes	0	5	6
554	B:B:L300	G:G:M38	2.83	Yes	No	0	6	4
555	B:B:L300	G:G:C41	6.35	Yes	No	0	6	7
556	B:B:R304	B:B:V307	6.54	No	No	0	5	3
557	B:B:L308	B:B:W339	5.69	No	Yes	0	7	9
558	B:B:H311	B:B:V315	4.15	Yes	No	9	9	7
559	B:B:H311	B:B:T329	6.85	Yes	No	0	9	8
560	B:B:G330	B:B:H311	3.18	No	Yes	0	5	9
561	B:B:H311	B:B:S331	12.55	Yes	No	9	9	9
562	B:B:D333	B:B:H311	6.3	Yes	Yes	9	9	9
563	B:B:H311	B:B:K337	5.24	Yes	Yes	9	9	6
564	B:B:D312	B:B:D333	2.66	No	Yes	0	5	9
565	B:B:N313	B:B:W332	10.17	No	Yes	0	7	9
566	B:B:D333	B:B:N313	4.04	Yes	No	0	9	7
567	B:B:R314	B:B:W332	19.99	Yes	Yes	1	8	9
568	B:B:S331	B:B:V315	3.23	No	No	9	9	7
569	B:B:S316	B:B:W332	7.41	No	Yes	0	9	9
570	B:B:V320	B:B:V327	3.21	No	No	0	7	6
571	B:B:D323	B:B:T321	5.78	No	Yes	3	7	7
572	B:B:D323	B:B:M325	5.54	No	Yes	3	7	5
573	B:B:M325	G:G:P49	5.03	Yes	No	0	5	7
574	B:B:M325	G:G:P60	3.35	Yes	Yes	3	5	9
575	B:B:M325	G:G:F61	2.49	Yes	Yes	3	5	8
576	B:B:A326	G:G:F61	5.55	No	Yes	0	7	8
577	B:B:V327	G:G:L50	4.47	No	No	0	6	9
578	B:B:T329	B:B:W339	8.49	No	Yes	0	8	9
579	B:B:D333	B:B:S331	5.89	Yes	No	9	9	9
580	B:B:D333	B:B:F335	5.97	Yes	No	0	9	4
581	B:B:K337	B:B:W339	6.96	Yes	Yes	9	6	9
582	B:B:I338	G:G:F61	5.02	No	Yes	3	5	8
583	B:B:N340	G:G:F61	2.42	No	Yes	0	9	8
584	G:G:I9	G:G:R13	2.51	No	No	0	2	6
585	G:G:L15	G:G:Q11	3.99	No	No	0	2	3
586	G:G:R13	G:G:V16	3.92	No	No	0	6	7
587	G:G:K20	G:G:V16	3.04	No	No	0	6	7
588	G:G:E17	G:G:K20	5.4	No	No	0	6	6
589	G:G:E22	G:G:Q18	12.74	No	No	0	9	9
590	G:G:I28	G:G:K32	7.27	No	No	0	4	5
591	G:G:K29	G:G:K32	10.06	No	No	0	4	5
592	G:G:H44	G:G:Y40	3.27	No	Yes	0	6	6
593	G:G:A43	G:G:E42	4.53	No	No	0	4	1
594	G:G:E47	G:G:K46	9.45	No	No	0	3	1
595	G:G:D48	G:G:L51	9.5	No	Yes	0	9	6
596	G:G:P55	G:G:V54	3.53	No	No	0	5	6
597	G:G:F61	G:G:P60	2.89	Yes	Yes	3	8	9
598	R:R:C107	R:R:E106	4.56	No	No	0	2	4
599	R:R:K373	R:R:M109	2.88	No	No	0	3	3
600	R:R:Q116	R:R:V110	7.16	Yes	No	0	4	3
601	R:R:H181	R:R:V110	2.77	No	No	0	3	3
602	R:R:L111	R:R:N112	4.12	Yes	Yes	20	4	6
603	R:R:L111	R:R:Q115	3.99	Yes	No	20	4	2
604	R:R:L111	R:R:Q116	2.66	Yes	Yes	20	4	4
605	R:R:L111	R:R:T377	4.42	Yes	No	0	4	1
606	R:R:N112	R:R:Q115	9.24	Yes	No	20	6	2
607	R:R:N112	R:R:Q116	5.28	Yes	Yes	20	6	4
608	R:R:Q115	R:R:Q116	11.52	No	Yes	20	2	4
609	R:R:I119	R:R:Q116	2.74	No	Yes	0	5	4
610	R:R:F381	R:R:I119	3.77	No	No	0	4	5
611	R:R:I119	R:R:M384	5.83	No	No	0	5	5
612	R:R:S123	R:R:V171	4.85	No	No	0	7	7
613	R:R:I175	R:R:L124	2.85	No	No	0	5	3
614	R:R:F129	R:R:T125	2.59	No	No	0	4	4
615	R:R:L126	R:R:T391	2.95	No	Yes	0	6	7
616	R:R:G127	R:R:T130	3.64	No	Yes	0	6	7
617	R:R:F129	R:R:L132	2.44	No	No	0	4	3
618	R:R:S167	R:R:T130	4.8	No	Yes	0	7	7
619	R:R:T130	R:R:T391	4.71	Yes	Yes	0	7	7
620	R:R:E133	R:R:L132	6.63	No	No	0	8	3
621	R:R:E133	R:R:L136	2.65	No	No	0	8	7
622	R:R:E133	R:R:I395	10.93	No	No	0	8	6
623	R:R:N134	R:R:V137	2.96	Yes	No	0	9	9
624	R:R:A160	R:R:N134	4.69	No	Yes	0	9	9
625	R:R:L164	R:R:N134	8.24	No	Yes	0	7	9
626	R:R:N134	R:R:P394	3.26	Yes	No	0	9	9
627	R:R:A398	R:R:V137	3.39	No	No	0	7	9
628	R:R:L138	R:R:L142	5.54	No	No	0	7	4
629	R:R:I141	R:R:V140	3.07	No	No	29	7	8
630	R:R:L404	R:R:V140	5.96	No	No	29	8	8
631	R:R:F408	R:R:V140	15.73	No	No	0	7	8
632	R:R:I141	R:R:L404	8.56	No	No	29	7	8
633	R:R:L142	R:R:S144	3	No	No	0	4	6
634	R:R:F408	R:R:H143	4.53	No	No	0	7	5
635	R:R:R148	R:R:S144	7.91	No	No	0	8	6
636	R:R:L147	R:R:Y153	7.03	No	No	0	9	9
637	R:R:R150	R:R:Y153	15.43	Yes	No	27	5	9
638	R:R:D403	R:R:R150	3.57	No	Yes	27	6	5
639	R:R:H154	R:R:P151	3.05	No	Yes	0	3	5
640	R:R:F155	R:R:P151	2.89	No	Yes	0	8	5
641	R:R:P151	R:R:V228	3.53	Yes	Yes	0	5	6
642	R:R:D213	R:R:S152	4.42	No	No	0	9	8
643	R:R:D403	R:R:Y153	8.05	No	No	27	6	9
644	R:R:A233	R:R:H154	2.93	No	No	0	7	3
645	R:R:F155	R:R:L209	7.31	No	No	0	8	6
646	R:R:A233	R:R:F155	2.77	No	No	0	7	8
647	R:R:I156	R:R:T210	3.04	No	No	0	8	9
648	R:R:I156	R:R:Y397	4.84	No	Yes	0	8	9
649	R:R:F237	R:R:S158	7.93	No	No	0	8	9
650	R:R:D163	R:R:L159	5.43	Yes	Yes	30	9	9
651	R:R:L159	R:R:S203	3	Yes	No	30	9	9
652	R:R:L159	R:R:S206	6.01	Yes	No	0	9	8
653	R:R:L159	R:R:L207	5.54	Yes	No	0	9	8
654	R:R:A162	R:R:W241	2.59	No	Yes	0	8	9
655	R:R:D163	R:R:S203	7.36	Yes	No	30	9	9
656	R:R:D163	R:R:S390	8.83	Yes	No	0	9	9
657	R:R:D163	R:R:P394	6.44	Yes	No	0	9	9
658	R:R:L165	W:W:?1	8.19	No	Yes	0	6	0
659	R:R:G166	R:R:I169	3.53	No	No	0	8	5
660	R:R:G166	R:R:S199	3.71	No	No	0	8	7
661	R:R:I169	R:R:V196	3.07	No	No	0	5	7
662	R:R:I169	W:W:?1	3.62	No	Yes	0	5	0
663	R:R:F170	R:R:F174	8.57	No	No	0	7	5
664	R:R:F170	R:R:L387	7.31	No	No	0	7	7
665	R:R:K192	R:R:S173	6.12	No	No	0	6	4
666	R:R:D176	R:R:F177	4.78	No	No	0	3	4
667	R:R:D176	R:R:R182	3.57	No	No	0	3	4
668	R:R:F177	R:R:F189	5.36	No	No	31	4	9
669	R:R:F177	R:R:K192	2.48	No	No	31	4	6
670	R:R:D184	R:R:R182	15.48	No	No	0	2	4
671	R:R:S185	R:R:V188	3.23	No	No	0	7	5
672	R:R:N187	R:R:R186	10.85	No	No	0	1	3
673	R:R:F189	R:R:K192	8.69	No	No	31	9	6
674	R:R:F191	W:W:?1	28.84	No	Yes	0	5	0
675	R:R:G194	W:W:?1	2.89	No	Yes	0	6	0
676	R:R:G195	W:W:?1	13.02	No	Yes	0	4	0
677	R:R:F200	R:R:V196	2.62	Yes	No	0	7	7
678	R:R:T197	R:R:Y275	3.75	No	Yes	0	6	7
679	R:R:T197	R:R:W279	7.28	No	No	0	6	6
680	R:R:F200	R:R:S199	2.64	Yes	No	0	7	7
681	R:R:C386	R:R:F200	4.19	No	Yes	0	7	7
682	R:R:T201	R:R:W279	7.28	No	No	0	6	6
683	R:R:A202	R:R:W241	7.78	No	Yes	0	7	9
684	R:R:T283	R:R:V204	4.76	No	No	16	8	7
685	R:R:L286	R:R:V204	2.98	Yes	No	0	8	7
686	R:R:V204	R:R:W356	3.68	No	Yes	16	7	8
687	R:R:G205	R:R:M240	3.49	No	No	0	5	6
688	R:R:L207	R:R:Y397	4.69	No	Yes	0	8	9
689	R:R:F208	R:R:I212	7.54	No	No	0	7	7
690	R:R:F208	R:R:L286	12.18	No	Yes	0	7	8
691	R:R:F208	R:R:F289	5.36	No	No	0	7	6
692	R:R:R214	R:R:T210	2.59	Yes	No	0	9	9
693	R:R:A211	R:R:I290	4.87	No	No	0	8	8
694	R:R:I212	R:R:I216	2.94	No	No	0	7	5
695	R:R:D213	R:R:Y224	8.05	No	Yes	26	9	7
696	R:R:D213	R:R:V228	4.38	No	Yes	26	9	6
697	R:R:R214	R:R:Y294	7.2	Yes	Yes	0	9	9
698	R:R:R214	R:R:Y397	6.17	Yes	Yes	0	9	9
699	R:R:H219	R:R:Y215	19.6	No	Yes	17	6	8
700	R:R:A293	R:R:Y215	4	No	Yes	0	7	8
701	R:R:Y215	R:R:Y296	13.9	Yes	Yes	17	8	4
702	R:R:I216	R:R:I227	4.42	No	No	0	5	4
703	R:R:I216	R:R:V228	3.07	No	Yes	0	5	6
704	R:R:I218	R:R:S217	4.64	Yes	No	0	9	8
705	R:R:S217	R:R:Y224	5.09	No	Yes	0	8	7
706	R:R:I218	R:R:I297	4.42	Yes	No	0	9	9
707	R:R:I218	R:R:K300	2.91	Yes	Yes	0	9	5
708	R:R:H219	R:R:R220	7.9	No	No	0	6	5
709	R:R:H219	R:R:Y296	13.07	No	Yes	17	6	4
710	R:R:A223	R:R:R226	5.53	No	No	0	5	4
711	R:R:V228	R:R:Y224	2.52	Yes	Yes	26	6	7
712	R:R:P231	R:R:T229	6.99	No	No	0	4	8
713	R:R:K232	R:R:T229	3	No	No	0	5	8
714	R:R:F237	R:R:W241	6.01	No	Yes	0	8	9
715	R:R:L239	R:R:T242	2.95	No	No	0	3	4
716	R:R:I243	R:R:L239	2.85	No	No	0	5	3
717	R:R:W241	W:W:?1	2.89	Yes	Yes	0	9	0
718	R:R:I245	W:W:?1	9.66	No	Yes	0	4	0
719	R:R:F278	R:R:I247	2.51	No	No	0	6	5
720	R:R:A248	W:W:?1	4	No	Yes	0	7	0
721	R:R:L250	R:R:P251	3.28	No	No	0	5	6
722	R:R:P251	R:R:Y275	19.47	No	Yes	0	6	7
723	R:R:L252	R:R:L253	5.54	No	No	0	5	5
724	R:R:I271	R:R:Y275	9.67	No	Yes	0	3	7
725	R:R:I271	R:R:L276	2.85	No	No	0	3	5
726	R:R:D272	R:R:T274	7.23	No	No	0	5	5
727	R:R:D272	R:R:Y275	3.45	No	Yes	0	5	7
728	R:R:E273	R:R:T274	8.47	No	No	0	3	5
729	R:R:I280	R:R:M277	5.83	Yes	No	0	5	4
730	R:R:F278	R:R:V282	3.93	No	No	0	6	6
731	R:R:G281	R:R:I280	3.53	No	Yes	0	3	5
732	R:R:I280	R:R:L360	5.71	Yes	No	0	5	7
733	R:R:I280	R:R:V364	3.07	Yes	No	0	5	6
734	R:R:T283	R:R:W356	3.64	No	Yes	16	8	8
735	R:R:L287	R:R:L352	5.54	No	No	0	6	9
736	R:R:L287	R:R:W356	4.56	No	Yes	0	6	8
737	R:R:I290	R:R:Y294	2.42	No	Yes	0	8	9
738	R:R:I297	R:R:Y294	2.42	No	Yes	0	9	9
739	R:R:L345	R:R:Y294	5.86	No	Yes	0	8	9
740	R:R:L349	R:R:Y294	10.55	No	Yes	0	8	9
741	R:R:W299	R:R:Y296	2.89	No	Yes	17	3	4
742	R:R:K300	R:R:Y296	5.97	Yes	Yes	17	5	4
743	R:R:K300	R:R:W299	5.8	Yes	No	17	5	3
744	R:R:A301	R:R:D338	3.09	No	Yes	0	8	7
745	R:R:D338	R:R:H302	8.82	Yes	No	0	7	5
746	R:R:H304	R:R:M308	2.63	Yes	No	4	7	7
747	R:R:H304	R:R:M337	3.94	Yes	No	4	7	6
748	R:R:K402	R:R:R340	2.48	No	No	0	5	7
749	R:R:R400	R:R:T344	15.52	No	No	0	7	8
750	R:R:I348	R:R:I396	2.94	No	No	0	8	9
751	R:R:I348	R:R:Y397	4.84	No	Yes	0	8	9
752	R:R:C355	R:R:W356	3.92	No	Yes	16	8	8
753	R:R:C355	R:R:N389	9.45	No	No	16	8	9
754	R:R:L360	R:R:W356	4.56	No	Yes	0	7	8
755	R:R:N389	R:R:W356	9.04	No	Yes	16	9	8
756	R:R:G357	R:R:P358	4.06	No	No	0	5	9
757	R:R:L359	R:R:L360	4.15	Yes	No	0	7	7
758	R:R:L359	R:R:M363	4.24	Yes	No	0	7	6
759	R:R:F379	R:R:L359	2.44	No	Yes	0	4	7
760	R:R:C386	R:R:L359	3.17	No	Yes	0	7	7
761	R:R:D366	R:R:I362	2.8	No	No	0	4	4
762	R:R:D366	R:R:I375	4.2	No	No	0	4	3
763	R:R:F368	R:R:V367	2.62	No	No	0	5	4
764	R:R:L374	R:R:T377	4.42	No	No	0	4	1
765	R:R:L374	R:R:V378	2.98	No	No	0	4	4
766	R:R:F379	R:R:S383	3.96	No	No	0	4	6
767	R:R:L388	R:R:T391	7.37	No	Yes	0	5	7
768	R:R:N389	R:R:N393	4.09	No	No	0	9	9
769	R:R:T391	R:R:V392	3.17	Yes	No	0	7	6
770	R:R:N393	R:R:Y397	3.49	No	Yes	0	9	9
771	R:R:K402	R:R:R405	8.66	No	No	0	5	8
772	R:R:H406	R:R:K402	5.24	No	No	0	4	5
773	A:A:M243	A:A:Y230	2.39	Yes	Yes	0	9	8
774	A:A:D337	A:A:F336	2.39	No	Yes	0	8	8
775	A:A:L283	A:A:Y290	2.34	No	Yes	0	5	6
776	A:A:E245	A:A:R242	2.33	No	Yes	0	4	9
777	R:R:H154	R:R:R230	2.26	No	No	0	3	1
778	B:B:R22	G:G:R27	2.13	No	No	0	6	8
779	A:A:G202	A:A:G203	2.11	No	No	0	9	9
780	B:B:G115	B:B:G116	2.11	No	No	0	9	9
781	R:R:F200	R:R:W279	2	Yes	No	0	7	6
782	A:A:C224	A:A:G40	1.96	No	No	0	9	9
783	A:A:C351	A:A:G352	1.96	Yes	No	0	4	4
784	B:B:C204	B:B:G185	1.96	Yes	No	0	7	5
785	B:B:A140	B:B:G141	1.95	No	No	0	5	5
786	B:B:A208	B:B:G202	1.95	No	No	0	6	6
787	B:B:A305	B:B:G306	1.95	No	No	0	4	4
788	B:B:A309	B:B:G310	1.95	No	No	0	3	5
789	R:R:A160	R:R:G157	1.95	No	No	0	9	6
790	R:R:A198	R:R:G195	1.95	No	No	0	5	4
791	R:R:C382	R:R:P358	1.88	No	No	0	5	9
792	B:B:A106	B:B:P107	1.87	No	No	0	6	6
793	B:B:A193	B:B:P194	1.87	No	No	0	4	4
794	A:A:G352	R:R:S401	1.86	No	No	0	4	8
795	B:B:G162	B:B:S161	1.86	No	No	1	9	9
796	R:R:G281	R:R:S284	1.86	No	No	0	3	5
797	B:B:G41	B:B:V40	1.84	No	Yes	0	1	3
798	B:B:G306	B:B:V296	1.84	No	Yes	0	4	5
799	A:A:G45	A:A:T48	1.82	No	No	0	9	9
800	B:B:G115	B:B:T102	1.82	No	No	0	9	8
801	B:B:G244	B:B:T243	1.82	No	Yes	0	5	8
802	B:B:G324	B:B:T321	1.82	No	Yes	0	9	7
803	B:B:A73	B:B:C103	1.81	No	No	0	9	8
804	R:R:A202	R:R:A244	1.79	No	No	0	7	8
805	R:R:A305	R:R:A335	1.79	No	No	0	5	4
806	A:A:P282	A:A:S281	1.78	No	No	0	7	1
807	G:G:P53	G:G:T52	1.75	No	No	0	8	4
808	A:A:G42	A:A:K46	1.74	No	No	0	8	9
809	B:B:G324	B:B:K280	1.74	No	No	0	9	1
810	A:A:C286	A:A:V233	1.71	No	No	0	3	8
811	B:B:A302	B:B:S31	1.71	No	No	0	2	1
812	B:B:G174	B:B:L139	1.71	No	No	0	4	9
813	R:R:G205	R:R:L286	1.71	No	Yes	0	5	8
814	B:B:A203	B:B:V187	1.7	No	No	0	8	9
815	B:B:A309	B:B:V307	1.7	No	No	0	3	3
816	R:R:G254	R:R:N256	1.7	No	No	0	5	6
817	A:A:A326	A:A:T327	1.68	No	No	0	7	9
818	A:A:G183	A:A:Q204	1.64	No	Yes	0	7	9
819	A:A:E216	A:A:G217	1.64	No	No	0	9	7
820	B:B:E215	B:B:G216	1.64	Yes	No	0	3	4
821	R:R:N112	R:R:P113	1.63	Yes	No	0	6	2
822	R:R:N256	R:R:P251	1.63	No	No	0	6	6
823	A:A:A338	A:A:I265	1.62	No	Yes	0	4	6
824	B:B:I18	G:G:A23	1.62	No	No	0	7	8
825	B:B:A208	B:B:I232	1.62	No	Yes	0	6	8
826	R:R:C107	R:R:M109	1.62	No	No	0	2	3
827	R:R:A120	R:R:I175	1.62	No	No	0	5	5
828	R:R:A223	R:R:I227	1.62	No	No	0	5	4
829	B:B:D38	B:B:P39	1.61	No	No	0	1	1
830	A:A:S47	A:A:T48	1.6	No	No	0	9	9
831	A:A:V335	A:A:V339	1.6	No	No	0	3	6
832	B:B:S31	B:B:T29	1.6	No	No	0	1	3
833	B:B:S207	B:B:T223	1.6	No	No	0	5	2
834	R:R:S390	R:R:T130	1.6	No	Yes	0	9	7
835	R:R:V351	R:R:V392	1.6	No	No	0	6	6
836	R:R:T125	R:R:V121	1.59	No	No	0	4	4
837	A:A:A220	A:A:L36	1.58	No	Yes	0	7	7
838	A:A:A299	A:A:L283	1.58	No	No	0	4	5
839	B:B:L7	G:G:A12	1.58	No	No	0	8	5
840	B:B:A240	B:B:L252	1.58	No	No	0	6	7
841	B:B:A240	G:G:L37	1.58	No	No	0	6	7
842	B:B:A299	B:B:L285	1.58	No	Yes	0	5	6
843	B:B:A299	B:B:L300	1.58	No	Yes	0	5	6
844	R:R:A236	R:R:L209	1.58	No	No	0	5	6
845	R:R:A342	R:R:L298	1.58	No	No	0	7	6
846	R:R:A301	R:R:L341	1.58	No	Yes	0	8	8
847	R:R:A398	R:R:L404	1.58	No	No	0	7	8
848	R:R:T125	R:R:T128	1.57	No	No	0	4	5
849	A:A:I49	A:A:V50	1.54	No	No	0	9	7
850	A:A:A326	A:A:D272	1.54	No	No	0	7	5
851	B:B:A302	B:B:D303	1.54	No	No	0	2	2
852	G:G:A45	G:G:D48	1.54	No	No	0	4	9
853	R:R:A305	R:R:D338	1.54	No	Yes	0	5	7
854	R:R:I354	R:R:V350	1.54	No	No	0	5	6
855	A:A:K270	A:A:S228	1.53	No	No	0	9	7
856	B:B:M262	B:B:S31	1.53	No	No	0	4	1
857	R:R:K300	R:R:S303	1.53	Yes	No	0	5	5
858	R:R:M384	R:R:S383	1.53	No	No	0	5	6
859	A:A:I285	A:A:T284	1.52	No	No	0	4	7
860	B:B:A21	B:B:Q17	1.52	No	Yes	0	4	4
861	B:B:I33	B:B:T34	1.52	No	No	0	3	5
862	B:B:A257	B:B:Q259	1.52	No	No	0	7	6
863	R:R:I247	R:R:T201	1.52	No	No	0	5	6
864	R:R:M277	R:R:V367	1.52	No	No	0	4	4
865	R:R:M295	R:R:V291	1.52	No	No	0	3	5
866	A:A:A301	A:A:E297	1.51	No	No	0	5	4
867	B:B:A206	B:B:E226	1.51	No	Yes	0	4	3
868	G:G:A39	G:G:E42	1.51	No	No	0	3	1
869	B:B:G306	B:B:R42	1.5	No	No	0	4	2
870	B:B:G53	B:B:R52	1.5	No	No	0	9	7
871	B:B:L318	B:B:S275	1.5	No	No	0	6	8
872	R:R:L147	R:R:S146	1.5	No	No	0	9	5
873	R:R:L387	R:R:S390	1.5	No	No	0	7	9
874	A:A:L5	A:A:V13	1.49	No	No	0	2	3
875	R:R:L164	R:R:V168	1.49	No	No	0	7	4
876	R:R:N187	R:R:S185	1.49	No	No	0	1	7
877	R:R:L253	R:R:V249	1.49	No	No	0	5	5
878	R:R:L286	R:R:V285	1.49	Yes	No	0	8	6
879	R:R:L349	R:R:V291	1.49	No	No	0	8	5
880	R:R:L352	R:R:V291	1.49	No	No	0	9	5
881	R:R:L347	R:R:V350	1.49	No	No	0	7	6
882	R:R:L347	R:R:V351	1.49	No	No	0	7	6
883	A:A:V13	B:B:N88	1.48	No	No	0	3	7
884	A:A:D229	A:A:S246	1.47	Yes	No	0	9	9
885	B:B:L51	B:B:T87	1.47	Yes	No	0	9	5
886	G:G:L51	G:G:T52	1.47	Yes	No	0	6	4
887	R:R:L193	R:R:T197	1.47	No	No	0	4	6
888	R:R:I353	R:R:I354	1.47	No	No	0	6	5
889	A:A:N269	A:A:T48	1.46	No	No	0	8	9
890	A:A:D200	A:A:V185	1.46	Yes	No	0	5	9
891	A:A:I303	A:A:M243	1.46	No	Yes	0	6	9
892	G:G:A43	G:G:H44	1.46	No	No	0	4	6
893	B:B:G109	B:B:Y105	1.45	No	Yes	0	5	6
894	A:A:K277	A:A:K280	1.44	No	No	0	5	2
895	G:G:P60	G:G:R62	1.44	Yes	No	0	9	7
896	R:R:P151	R:R:R150	1.44	Yes	Yes	0	5	5
897	R:R:P231	R:R:R230	1.44	No	No	0	4	1
898	R:R:K376	R:R:M371	1.44	No	No	0	2	1
899	B:B:Q32	B:B:T29	1.42	No	No	0	1	3
900	R:R:I375	R:R:N372	1.42	No	No	0	3	1
901	A:A:L310	A:A:M247	1.41	No	No	0	4	9
902	B:B:L14	G:G:K20	1.41	Yes	No	0	8	6
903	R:R:L239	R:R:M240	1.41	No	No	0	3	6
904	A:A:K270	A:A:N269	1.4	No	No	0	9	8
905	A:A:K314	A:A:N311	1.4	No	Yes	0	4	4
906	G:G:M21	G:G:N24	1.4	No	No	0	1	1
907	G:G:D26	G:G:I25	1.4	No	No	0	1	2
908	A:A:P288	A:A:Y287	1.39	No	No	0	7	6
909	B:B:L14	G:G:L19	1.38	Yes	No	0	8	9
910	G:G:L15	G:G:L19	1.38	No	No	0	2	9
911	R:R:L138	R:R:N134	1.37	No	Yes	0	7	9
912	A:A:D272	A:A:L273	1.36	No	No	0	5	9
913	R:R:D338	R:R:L298	1.36	Yes	No	0	7	6
914	B:B:E12	B:B:K15	1.35	No	No	0	4	6
915	B:B:D20	B:B:N16	1.35	No	No	0	2	1
916	B:B:K280	G:G:E47	1.35	No	No	0	1	3
917	B:B:E3	B:B:L4	1.33	No	No	0	5	4
918	B:B:E3	B:B:L7	1.33	No	No	0	5	8
919	R:R:A361	R:R:Y365	1.33	No	No	0	5	4
920	B:B:N16	B:B:Q13	1.32	No	Yes	14	1	1
921	B:B:N16	B:B:Q17	1.32	No	Yes	14	1	4
922	R:R:R145	R:R:S146	1.32	No	No	0	6	5
923	R:R:R307	R:R:S303	1.32	No	No	0	4	5
924	A:A:E25	A:A:N22	1.31	No	No	0	4	4
925	A:A:D272	A:A:E276	1.3	No	No	0	5	5
926	B:B:R46	B:B:T47	1.29	No	No	0	5	3
927	B:B:E10	B:B:Q6	1.27	No	No	0	8	1
928	R:R:V364	R:R:Y365	1.26	No	No	0	6	4
929	R:R:I339	R:R:R336	1.25	No	No	0	5	4
930	R:R:I396	R:R:R400	1.25	No	No	0	9	7
931	B:B:K23	B:B:R19	1.24	No	No	0	2	4
932	B:B:K23	B:B:R22	1.24	No	No	0	2	6
933	R:R:F189	R:R:K183	1.24	No	No	0	9	6
934	R:R:K343	R:R:R400	1.24	No	No	0	7	7
935	A:A:I278	A:A:Y296	1.21	No	No	0	9	5
936	R:R:L190	R:R:R186	1.21	No	No	0	5	3
937	B:B:R49	G:G:E63	1.16	No	No	0	7	6
938	R:R:F108	R:R:H181	1.13	No	No	0	5	3
939	A:A:R21	A:A:R24	1.07	No	No	0	4	3
940	R:R:Y215	R:R:Y292	0.99	Yes	No	0	8	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	A:A:L36	3.07	4	13	7
2	A:A:L38	6.67	4	22	8
3	A:A:I184	4.7775	4	1	9
4	A:A:F191	8.705	4	24	3
5	A:A:F196	5.105	4	13	4
6	A:A:K197	10.355	4	1	7
7	A:A:F199	6.23	6	1	7
8	A:A:D200	5.055	4	22	5
9	A:A:Q204	3.3075	4	1	9
10	A:A:S206	3.3475	4	1	9
11	A:A:E207	8.785	4	1	8
12	A:A:K210	7.546	5	1	8
13	A:A:W211	6.265	4	1	9
14	A:A:F215	4.05286	7	1	7
15	A:A:F223	7.075	4	5	7
16	A:A:D229	7.5875	4	0	9
17	A:A:Y230	4.93	4	0	8
18	A:A:N241	4.17	4	0	6
19	A:A:R242	10.4125	4	0	9
20	A:A:M243	3.4	4	0	9
21	A:A:F250	6.002	5	5	9
22	A:A:C254	3.712	5	5	8
23	A:A:W258	7.042	5	1	4
24	A:A:F259	7.2325	4	23	5
25	A:A:I265	2.58	4	0	6
26	A:A:L266	3.94	5	5	8
27	A:A:F267	4.25	5	7	9
28	A:A:L268	5.0275	4	5	9
29	A:A:Y290	4.4025	4	0	6
30	A:A:F307	4.6525	4	5	5
31	A:A:N311	3.2925	4	5	4
32	A:A:K317	3.466	5	5	3
33	A:A:Y320	4.9475	4	0	5
34	A:A:H322	8.585	4	7	5
35	A:A:T324	4.822	5	7	4
36	A:A:D328	6.1825	4	7	8
37	A:A:N331	5.158	5	7	4
38	A:A:F336	9.27	4	24	8
39	A:A:D341	6.9325	4	4	6
40	A:A:L348	3.706	5	4	8
41	A:A:C351	4.3975	4	4	4
42	A:A:L353	4.6075	4	4	8
43	A:A:F354	5.418	5	4	7
44	B:B:Q13	3.2425	4	14	1
45	B:B:L14	2.69	4	14	8
46	B:B:Q17	2.38	4	14	4
47	B:B:L30	5.1025	4	0	5
48	B:B:V40	5.015	4	18	3
49	B:B:L51	8.17	4	0	9
50	B:B:H54	6.406	5	15	9
51	B:B:I58	4.4675	4	15	9
52	B:B:Y59	4.705	4	1	8
53	B:B:M61	4.5975	4	0	6
54	B:B:W63	6.12833	6	3	7
55	B:B:R68	9.4725	4	0	5
56	B:B:L70	4.59	4	3	5
57	B:B:V71	3.315	4	0	8
58	B:B:S74	5.6175	4	15	9
59	B:B:D76	5.315	4	15	9
60	B:B:L79	3.635	4	0	7
61	B:B:W82	10.668	5	0	9
62	B:B:S84	3.965	4	3	5
63	B:B:K89	7.9975	4	21	9
64	B:B:I93	4.305	4	10	7
65	B:B:L95	4.8225	4	0	8
66	B:B:W99	6.30875	8	1	9
67	B:B:Y105	3.53714	7	10	6
68	B:B:Y111	6.338	5	11	4
69	B:B:I123	3.36	4	11	6
70	B:B:Y124	4.83857	7	10	6
71	B:B:V133	4.9575	4	10	4
72	B:B:H142	5.375	8	1	9
73	B:B:Y145	4.38714	7	1	8
74	B:B:R150	6.6425	4	12	6
75	B:B:F151	3.715	4	0	9
76	B:B:T159	5.8	4	1	9
77	B:B:D163	7.3375	4	1	9
78	B:B:L168	3.948	5	8	6
79	B:B:W169	9.036	5	1	8
80	B:B:I171	3.5125	4	0	6
81	B:B:Q176	7.11	4	1	4
82	B:B:F180	6.232	5	8	7
83	B:B:D186	5.754	5	1	9
84	B:B:M188	5.64	4	1	8
85	B:B:L190	6.0875	4	12	5
86	B:B:F199	7.23	5	0	9
87	B:B:C204	4.515	6	1	7
88	B:B:K209	6.8	4	8	6
89	B:B:W211	8.714	5	8	8
90	B:B:E215	4.9375	4	19	3
91	B:B:F222	5.98	4	2	8
92	B:B:E226	5.536	5	2	3
93	B:B:D228	8.4425	4	1	9
94	B:B:I232	4.4	5	2	8
95	B:B:F235	7.99167	6	6	6
96	B:B:P236	7.1	4	6	7
97	B:B:N237	5.6125	4	6	5
98	B:B:F241	5.14833	6	2	6
99	B:B:T243	3.54	4	2	8
100	B:B:R251	8.812	5	2	8
101	B:B:F253	5.1175	4	2	6
102	B:B:Y264	5.152	5	0	5
103	B:B:I269	4.865	4	1	4
104	B:B:C271	4.99	4	1	5
105	B:B:F278	4.932	5	6	7
106	B:B:R283	7.968	5	18	9
107	B:B:L285	3.89	4	6	6
108	B:B:Y289	6.09	6	1	7
109	B:B:D290	6.7525	4	1	6
110	B:B:N295	5.9775	4	1	6
111	B:B:V296	4.185	4	0	5
112	B:B:W297	5.968	5	1	8
113	B:B:L300	3.395	4	0	6
114	B:B:K301	7.365	4	18	5
115	B:B:H311	6.37833	6	9	9
116	B:B:R314	9.67	4	1	8
117	B:B:T321	6.1325	4	3	7
118	B:B:M325	4.1025	4	3	5
119	B:B:W332	11.8767	6	1	9
120	B:B:D333	4.972	5	9	9
121	B:B:K337	5.3	4	9	6
122	B:B:W339	7.4075	4	9	9
123	G:G:Y40	6.115	4	6	6
124	G:G:L51	4.0425	4	0	6
125	G:G:P60	2.9625	4	3	9
126	G:G:F61	4.53625	8	3	8
127	R:R:L111	3.7975	4	20	4
128	R:R:N112	5.0675	4	20	6
129	R:R:Q116	5.872	5	20	4
130	R:R:T130	3.6875	4	0	7
131	R:R:N134	4.104	5	0	9
132	R:R:R150	6.0025	4	27	5
133	R:R:P151	2.7275	4	0	5
134	R:R:L159	4.995	4	30	9
135	R:R:D163	7.015	4	30	9
136	R:R:F200	2.8625	4	0	7
137	R:R:R214	6.25	5	4	9
138	R:R:Y215	9.6225	4	17	8
139	R:R:I218	3.705	4	0	9
140	R:R:Y224	6.8225	4	26	7
141	R:R:V228	3.375	4	26	6
142	R:R:W241	4.8175	4	0	9
143	R:R:Y275	9.085	4	0	7
144	R:R:I280	4.535	4	0	5
145	R:R:L286	4.59	4	0	8
146	R:R:Y294	5.69	5	0	9
147	R:R:Y296	8.9575	4	17	4
148	R:R:K300	4.0525	4	17	5
149	R:R:H304	3.88	4	4	7
150	R:R:D338	3.7025	4	0	7
151	R:R:L341	3.3025	4	4	8
152	R:R:W356	4.9	6	16	8
153	R:R:L359	3.5	4	0	7
154	R:R:T391	4.55	4	0	7
155	R:R:Y397	4.806	5	0	9
156	W:W:?1	9.13875	8	0	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	B:B:S122	B:B:Y124	24.1662	3.82	No	Yes	0	8	6
2	B:B:E138	B:B:S122	24.3971	4.31	No	No	0	6	8
3	B:B:E138	B:B:I120	24.6285	6.83	No	No	0	6	6
4	B:B:D118	B:B:I120	25.326	8.4	No	No	0	9	6
5	B:B:D118	B:B:S97	25.5683	8.83	No	No	0	9	8
6	B:B:S97	B:B:W99	25.8195	3.71	No	Yes	0	8	9
7	A:A:F215	B:B:W99	77.811	5.01	Yes	Yes	1	7	9
8	A:A:F215	A:A:W211	79.0358	4.01	Yes	Yes	1	7	9
9	A:A:R208	A:A:W211	100	10	No	Yes	0	9	9
10	A:A:L39	A:A:R208	98.8578	3.64	No	No	0	9	9
11	A:A:I253	A:A:L39	98.5419	7.14	No	No	0	7	9
12	A:A:I253	A:A:L249	98.3699	4.28	No	No	0	7	5
13	A:A:F223	A:A:L249	98.1973	6.09	Yes	No	0	7	5
14	A:A:F223	A:A:L266	91.6334	2.44	Yes	Yes	5	7	8
15	A:A:L266	A:A:L268	81.9024	5.54	Yes	Yes	5	8	9
16	A:A:F323	A:A:L268	87.3979	2.44	No	Yes	0	9	9
17	A:A:F323	A:A:K271	87.3142	8.69	No	No	0	9	9
18	A:A:C325	A:A:K271	87.094	6.47	No	No	0	9	9
19	A:A:C325	A:A:D328	86.8732	10.89	No	Yes	0	9	8
20	A:A:D328	A:A:T324	84.3365	4.34	Yes	Yes	7	8	4
21	A:A:F267	A:A:T324	82.5173	2.59	Yes	Yes	7	9	4
22	A:A:F267	A:A:I265	78.2291	3.77	Yes	Yes	0	9	6
23	A:A:I265	A:A:Y320	78.207	2.42	Yes	Yes	0	6	5
24	A:A:D341	A:A:Y320	76.6634	3.45	Yes	Yes	0	6	5
25	A:A:D341	R:R:H304	75.9183	6.3	Yes	Yes	4	6	7
26	R:R:H304	R:R:M337	72.1797	3.94	Yes	No	4	7	6
27	A:A:L348	R:R:M337	67.4664	2.83	Yes	No	4	8	6
28	A:A:L348	R:R:I218	20.6185	2.85	Yes	Yes	0	8	9
29	R:R:I218	R:R:S217	14.0861	4.64	Yes	No	0	9	8
30	R:R:S217	R:R:Y224	14.1114	5.09	No	Yes	0	8	7
31	R:R:V228	R:R:Y224	11.7294	2.52	Yes	Yes	26	6	7
32	A:A:I303	A:A:M243	14.8496	1.46	No	Yes	0	6	9
33	A:A:F307	A:A:I303	12.51	7.54	Yes	No	0	5	6
34	A:A:F307	A:A:L266	11.0892	3.65	Yes	Yes	5	5	8
35	B:B:L117	B:B:W99	29.1327	5.69	No	Yes	0	9	9
36	A:A:Q204	B:B:L117	28.7998	5.32	Yes	No	0	9	9
37	A:A:S206	A:A:W211	25.7289	2.47	Yes	Yes	1	9	9
38	A:A:Q204	B:B:Y145	26.4834	3.38	Yes	Yes	1	9	8
39	A:A:S206	B:B:D186	14.6589	2.94	Yes	Yes	1	9	9
40	B:B:I58	B:B:L336	19.7179	2.85	Yes	No	0	9	7
41	B:B:G330	B:B:I58	28.5351	3.53	No	Yes	0	5	9
42	B:B:G330	B:B:H311	28.8483	3.18	No	Yes	0	5	9
43	B:B:D333	B:B:H311	45.6492	6.3	Yes	Yes	9	9	9
44	B:B:D333	B:B:N313	47.7486	4.04	Yes	No	0	9	7
45	B:B:N313	B:B:W332	48.3728	10.17	No	Yes	0	7	9
46	A:A:C214	B:B:Y59	49.4959	2.69	No	Yes	1	8	8
47	B:B:W332	B:B:Y59	97.7121	5.79	Yes	Yes	1	9	8
48	B:B:Q75	B:B:Y59	49.4956	6.76	No	Yes	1	9	8
49	B:B:R314	B:B:W332	56.3527	19.99	Yes	Yes	1	8	9
50	A:A:L348	A:A:L353	45.1655	2.77	Yes	Yes	4	8	8
51	A:A:L353	R:R:R214	44.4254	9.72	Yes	Yes	4	8	9
52	B:B:D290	B:B:R314	55.8246	13.1	Yes	Yes	1	6	8
53	B:B:C271	B:B:D290	55.1841	6.22	Yes	Yes	1	5	6
54	B:B:C271	B:B:Y289	51.8126	2.69	Yes	Yes	1	5	7
55	B:B:I273	B:B:Y289	29.4211	12.09	No	Yes	0	6	7
56	B:B:G244	B:B:I273	29.0254	3.53	No	No	0	5	6
57	B:B:G244	B:B:T243	28.6291	1.82	No	Yes	0	5	8
58	B:B:F241	B:B:T243	16.6073	2.59	Yes	Yes	2	6	8
59	B:B:F222	B:B:F241	11.4184	9.65	Yes	Yes	2	8	6
60	B:B:D258	B:B:F222	10.5858	5.97	No	Yes	2	7	8
61	B:B:D258	G:G:R27	10.188	8.34	No	No	0	7	8
62	B:B:W297	B:B:Y289	25.53	9.65	Yes	Yes	1	8	7
63	B:B:W297	B:B:Y264	24.9526	4.82	Yes	Yes	0	8	5
64	B:B:H311	B:B:T329	12.885	6.85	Yes	No	0	9	8
65	B:B:T329	B:B:W339	12.5334	8.49	No	Yes	0	8	9
66	B:B:L308	B:B:W339	24.4897	5.69	No	Yes	0	7	9
67	B:B:L308	B:B:V296	19.541	2.98	No	Yes	0	7	5
68	B:B:L284	B:B:V296	12.6887	5.96	No	Yes	0	5	5
69	B:B:H311	B:B:K337	14.766	5.24	Yes	Yes	9	9	6
70	B:B:K337	B:B:W339	12.6072	6.96	Yes	Yes	9	6	9
71	B:B:H62	B:B:Y105	13.8685	3.27	No	Yes	0	6	6
72	B:B:H62	B:B:R150	13.5918	13.54	No	Yes	0	6	6
73	B:B:G162	B:B:Y145	32.2667	4.35	No	Yes	1	9	8
74	B:B:G162	B:B:S161	42.9562	1.86	No	No	1	9	9
75	B:B:H142	B:B:S161	40.897	13.95	Yes	No	1	9	9
76	B:B:H142	B:B:T159	13.8368	5.48	Yes	Yes	1	9	9
77	B:B:T159	B:B:W169	11.7856	9.7	Yes	Yes	1	9	8
78	B:B:I157	B:B:W169	30.264	3.52	No	Yes	0	7	8
79	B:B:I157	B:B:I171	29.0091	2.94	No	Yes	0	7	6
80	B:B:I123	B:B:I171	21.4686	2.94	Yes	Yes	0	6	6
81	B:B:A167	B:B:H142	12.1576	4.39	No	Yes	1	4	9
82	B:B:A167	B:B:W169	11.7457	5.19	No	Yes	1	4	8
83	B:B:H142	B:B:Q176	12.5784	2.47	Yes	Yes	1	9	4
84	B:B:Q176	B:B:W169	11.7544	14.24	Yes	Yes	1	4	8
85	B:B:V112	B:B:Y105	14.5636	2.52	No	Yes	10	8	6
86	B:B:I123	B:B:Y111	10.1155	3.63	Yes	Yes	11	6	4
87	B:B:L190	B:B:R150	11.0128	2.43	Yes	Yes	12	5	6
88	B:B:L285	B:B:Y264	14.3745	3.52	Yes	Yes	0	6	5
89	R:R:R214	R:R:Y397	42.1072	6.17	Yes	Yes	0	9	9
90	R:R:N393	R:R:Y397	27.5793	3.49	No	Yes	0	9	9
91	R:R:N389	R:R:N393	27.2459	4.09	No	No	0	9	9
92	R:R:N389	R:R:W356	26.5678	9.04	No	Yes	16	9	8
93	R:R:L360	R:R:W356	23.8873	4.56	No	Yes	0	7	8
94	R:R:L359	R:R:L360	20.3586	4.15	Yes	No	0	7	7
95	R:R:L207	R:R:Y397	14.045	4.69	No	Yes	0	8	9
96	R:R:L159	R:R:L207	13.6866	5.54	Yes	No	0	9	8
97	R:R:D163	R:R:L159	12.5949	5.43	Yes	Yes	30	9	9
98	R:R:C386	R:R:L359	13.8727	3.17	No	Yes	0	7	7
99	R:R:C386	R:R:F200	13.5073	4.19	No	Yes	0	7	7
100	A:A:C214	B:B:W99	49.5779	2.61	No	Yes	1	8	9
101	B:B:Q75	B:B:W99	49.5776	7.67	No	Yes	1	9	9
102	B:B:V112	B:B:Y124	14.9681	3.79	No	Yes	10	8	6
103	B:B:L336	B:B:M61	12.1558	4.24	No	Yes	0	7	6
104	A:A:S206	B:B:Y145	11.7363	5.09	Yes	Yes	1	9	8
105	B:B:D186	B:B:G162	11.0785	3.35	Yes	No	1	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:A162	R:R:W241	2.59	No	Yes	8	9	2	1
R:R:L165	W:W:?1	8.19	No	Yes	6	0	1	0
R:R:G166	R:R:I169	3.53	No	No	8	5	2	1
R:R:I169	R:R:V196	3.07	No	No	5	7	1	2
R:R:I169	W:W:?1	3.62	No	Yes	5	0	1	0
R:R:F191	W:W:?1	28.84	No	Yes	5	0	1	0
R:R:G194	W:W:?1	2.89	No	Yes	6	0	1	0
R:R:G195	W:W:?1	13.02	No	Yes	4	0	1	0
R:R:A202	R:R:W241	7.78	No	Yes	7	9	2	1
R:R:F237	R:R:W241	6.01	No	Yes	8	9	2	1
R:R:W241	W:W:?1	2.89	Yes	Yes	9	0	1	0
R:R:I245	W:W:?1	9.66	No	Yes	4	0	1	0
R:R:A248	W:W:?1	4	No	Yes	7	0	1	0
R:R:A198	R:R:G195	1.95	No	No	5	4	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
58.33	Single	8Y73	MPAM-15	8Y73-μ-Peptide-MPAM-15-Gi1/β1/γ2
55.56	Single	8IKG	Q2B	8IKG-CB₁-Q2B-Gi1/β1/γ1
54.55	Single	7WV9	ZCZ011	7WV9-CB₁-CP55940-ZCZ011-Gi2/β1/γ2
45.45	Single	7FEE	ZCZ011	7FEE-CB₁-CP55940-ZCZ011
33.33	Single	5NDZ	AZ3451; Na	5NDZ-PAR2-AZ3451; Na
21.43	Single	8T3V	Docosa-4,7,10,13,16,19-Hexaenoic acid	8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67	Single	6KQI	Org27569	6KQI-CB₁-CP55940-Org27569
11.76	Single	8EJK	TAK-875	8EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
11.11	Single	4PHU	Fasiglifam	4PHU-FFA1-Fasiglifam
11.11	Single	8EJC	TAK-875	8EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.53	Single	5TZR	MK8666	5TZR-FFA1-MK8666
10.00	Single	5TZY	MK8666; AP8	5TZY-FFA1-MK8666; AP8
9.52	Single	9JH5	C16:0 Ceramide	9JH5-CysLT₂-C16:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09	Single	9CM7	TUG-1375	9CM7-FFA2-TUG-1375-AZ-1729-Gi1/β1/γ2
9.09	Single	9NS9	TUG-1375	9NS9-FFA2-TUG-1375-Compound 187-Gi1/β1/γ2
8.00	Single	9M1O	Morphine-Modulating Neuropeptide B	9M1O-NPFF2-Morphine-Modulating Neuropeptide B-Gi1/β1/γ2
7.69	Single	7Y14	Beta-Alanine	7Y14-MRGPRD-β-Alanine
7.14	Single	7Y12	Beta-Alanine	7Y12-MRGPRD-β-Alanine-Gi1/β1/γ2
6.67	Single	8YN2	Histamine	8YN2-H₁-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
6.25	Single	4XNV	BPTU	4XNV-P2Y₁-BPTU
6.25	Single	6ME2	Ramelteon	6ME2-MT₁-Ramelteon
6.25	Single	7T8X	Acetylcholine	7T8X-M₂-Acetylcholine-chim(NtGi1-Go)/β1/γ2
6.25	Single	7T90	Acetylcholine	7T90-M₂-Acetylcholine-chim(NtGi1-Go)/β1/γ2
6.25	Single	7T96	Acetylcholine	7T96-M₂-Acetylcholine-LY2119620-Go/β1/γ2
6.25	Single	8G94	CD69	8G94-S1P₁-CD69-Gi1/β1/γ2
6.25	Single	8J20	Valeric acid	8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
6.25	Single	8T3S	Butyric acid	8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.25	Single	8YUV	Immepip	8YUV-H₃-Immepip-Gi1/β1/γ2
6.25	Single	9LRB	Histamine	9LRB-H₁-Histamine-Gs/β1/γ2
6.25	Consensus	m2_on	Orthosteric Ligand	7T8X-M₂-Acetylcholine-chim(NtGi1-Go)/β1/γ2
6.25	Consensus	m2_on_gp	Orthosteric Ligand	7T8X-M₂-Acetylcholine-chim(NtGi1-Go)/β1/γ2
5.88	Single	3RZE	Cidoxepin	3RZE-H₁-Cidoxepin
5.88	Single	4MQT	Iperoxo	4MQT-M₂-Iperoxo-LY2119620
5.88	Single	6ME4	2-Iodomelatonin	6ME4-MT₁-2-Iodomelatonin
5.88	Single	6PS8	2-Phenylmelatonin	6PS8-MT₁-2-Phenylmelatonin
5.88	Single	6TPK	Retosiban	6TPK-OT-Retosiban
5.88	Single	6VI4	JDTic	6VI4-κ-JDTic
5.88	Single	7T94	Acetylcholine	7T94-M₂-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
5.88	Single	7TRS	Acetylcholine	7TRS-M₄-Acetylcholine-Gi1/β1/γ2
5.88	Single	8HQN	9-S-HODE	8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
5.88	Single	8IYX	YL-365	8IYX-GPR34-YL-365
5.88	Single	8K4N	VF0	8K4N-GPR34-VF0-Gi1/β1/γ2
5.88	Single	8Y53	MK5046	8Y53-BB₃-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88	Single	9K1D	Butanoic acid	9K1D-FFA2-Butanoic acid-Gi1/β1/γ2
5.88	Single	9LRD	Histamine	9LRD-H₁-Histamine-Gi1/β1/γ2
5.88	Consensus	ot_off	Orthosteric Ligand	6TPK-OT-Retosiban
5.88	Consensus	vasop-oxy_off	Orthosteric Ligand	ot_off
5.56	Single	4DAJ	Tiotropium	4DAJ-M₃-Tiotropium
5.56	Single	4MQS	Iperoxo	4MQS-M₂-Iperoxo
5.56	Single	4U14	Tiotropium	4U14-M₃-Tiotropium
5.56	Single	5DSG	Tiotropium	5DSG-M₄-Tiotropium
5.56	Single	5YC8	N-Methyl-Scopolamine	5YC8-M₂-N-Methyl-Scopolamine
5.56	Single	5ZK8	N-Methyl-Scopolamine	5ZK8-M₂-N-Methyl-Scopolamine
5.56	Single	5ZKC	N-Methyl-Scopolamine	5ZKC-M₂-N-Methyl-Scopolamine
5.56	Single	7PP1	Selatogrel	7PP1-P2Y₁₂-Selatogrel
5.56	Single	7TRP	Iperoxo	7TRP-M₄-Iperoxo-LY2033298-Gi1/β1/γ2
5.56	Single	7VH0	Ramelteon	7VH0-MT₂-Ramelteon-Gi1/β1/γ1
5.56	Single	8DZS	GR89,696	8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
5.56	Single	8X63	Mepyramine	8X63-H₁-Mepyramine
5.56	Single	8YN8	Proxyfan	8YN8-H₃-Proxyfan-Go/β1/γ2
5.56	Consensus	gi_histamine	Orthosteric Ligand	8JXX-H₄-Clobenpropit-Gi1/β1/γ2 8JXV-H₄-Clozapine-Gi1/β1/γ2 8YUU-H₃-Histamine-Gi1/β1/γ1 8HN8-H₄-Histamine-Gi1/β1/γ2 8HOC-H₄-Imetit-Gi1/β1/γ2 8JXW-H₄-VUF6884-Gi1/β1/γ2
5.56	Consensus	gq_amine	Orthosteric Ligand	gq_muscarinic gq_histamine
5.56	Consensus	histamine_off	Orthosteric Ligand	h1_off
5.56	Consensus	m4_off	Orthosteric Ligand	5DSG-M₄-Tiotropium
5.56	Consensus	muscarinic_on	Orthosteric Ligand	m2_on m3_on m4_on m1_on
5.56	Consensus	muscarinic_on_gp	Orthosteric Ligand	m2_on_gp m3_on_gp m4_on_gp m1_on_gp
5.26	Single	4NTJ	AZD1283	4NTJ-P2Y₁₂-AZD1283
5.26	Single	5XPR	Bosentan	5XPR-ET_B-Bosentan
5.26	Single	5ZK3	3-quinuclidinyl-benzilate	5ZK3-M₂-3-quinuclidinyl-benzilate
5.26	Single	6ME7	2-Phenylmelatonin	6ME7-MT₂-2-Phenylmelatonin
5.26	Single	6OIK	Iperoxo	6OIK-M₂-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
5.26	Single	7TRK	Iperoxo	7TRK-M₄-Iperoxo-Gi1/β1/γ2
5.26	Single	8IZ4	Lysophosphatidylserine	8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
5.26	Single	8J18	(3R)-3-Hydroxydodecanoic acid	8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
5.26	Single	9DQH	EP-2825	9DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26	Single	9HAP	Tolvaptan	9HAP-V₂-Tolvaptan
5.26	Single	9K07	DSO-5a	9K07-BB₃-DSO-5a-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.26	Consensus	cyslt_off	Orthosteric Ligand	cyslt2_off cyslt1_off
5.26	Consensus	gq_muscarinic	Orthosteric Ligand	6OIJ-M₁-Iperoxo-chim(NtGi1L-G11)/β1/γ2
5.26	Consensus	h1_off	Orthosteric Ligand	8X63-H₁-Mepyramine 3RZE-H₁-Cidoxepin 8X5Y-H₁-Astemizole
5.26	Consensus	m1_on	Orthosteric Ligand	6OIJ-M₁-Iperoxo-chim(NtGi1L-G11)/β1/γ2
5.26	Consensus	m2_off	Orthosteric Ligand	5ZKC-M₂-N-Methyl-Scopolamine 5ZK3-M₂-3-quinuclidinyl-benzilate 5ZKB-M₂-AF-DX 384
5.26	Consensus	m3_on	Orthosteric Ligand	8E9Z-M₃-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M₃-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M₃-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.26	Consensus	m3_on_gp	Orthosteric Ligand	8E9Z-M₃-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M₃-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M₃-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.00	Single	3UON	3-quinuclidinyl-benzilate	3UON-M₂-3-quinuclidinyl-benzilate
5.00	Single	4DJH	JDTic	4DJH-κ-JDTic
5.00	Single	4U15	Tiotropium	4U15-M₃-Tiotropium
5.00	Single	5ZHP	PubChem 134828589	5ZHP-M₃-PubChem 134828589
5.00	Single	6OIJ	Iperoxo	6OIJ-M₁-Iperoxo-chim(NtGi1L-G11)/β1/γ2
5.00	Single	6OL9	Tiotropium	6OL9-M₅-Tiotropium
5.00	Single	6RZ5	Zafirlukast	6RZ5-CysLT₁-Zafirlukast-Na
5.00	Single	7R0C	AVP	7R0C-V₂-AVP-Arrestin2
5.00	Single	7TRQ	Iperoxo	7TRQ-M₄-Iperoxo-VU0467154-Gi1/β1/γ2
5.00	Single	8EA0	Iperoxo	8EA0-M₃-Iperoxo
5.00	Single	8IYH	MK6892	8IYH-HCA₂-MK6892-Go/β1/γ2
5.00	Single	8JGF	BAM8-22	8JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00	Single	8JXV	Clozapine	8JXV-H₄-Clozapine-Gi1/β1/γ2
5.00	Single	8JXW	VUF6884	8JXW-H₄-VUF6884-Gi1/β1/γ2
5.00	Single	8XBI	S3E-LysoPS	8XBI-GPR34-S3E-LysoPS
5.00	Single	9ITE	LPA	9ITE-LPA₆-LPA-chim(NtGi2-G13)/β1/γ2
5.00	Consensus	ffa2_on	Orthosteric Ligand	8J22-FFA2-TUG-1375-Gi1/β1/γ2
5.00	Consensus	h4_on_gp	Orthosteric Ligand	8HN8-H₄-Histamine-Gi1/β1/γ2 8HOC-H₄-Imetit-Gi1/β1/γ2 8JXV-H₄-Clozapine-Gi1/β1/γ2 8JXW-H₄-VUF6884-Gi1/β1/γ2 8JXX-H₄-Clobenpropit-Gi1/β1/γ2
5.00	Consensus	kop_off	Orthosteric Ligand	4DJH-κ-JDTic
5.00	Consensus	m1_on_gp	Orthosteric Ligand	6OIJ-M₁-Iperoxo-chim(NtGi1L-G11)/β1/γ2
5.00	Consensus	m3_off	Orthosteric Ligand	4U15-M₃-Tiotropium 4U16-M₃-N-Methyl-Scopolamine 5ZHP-M₃-PubChem 134828589
5.00	Consensus	m5_off	Orthosteric Ligand	6OL9-M₅-Tiotropium
5.00	Consensus	muscarinic_off	Orthosteric Ligand	m2_off m3_off m4_off m5_off m1_off
5.00	Consensus	p2y12_on	Orthosteric Ligand	7XXI-P2Y₁₂-2MeSADP-Gi2/β1/γ2
4.76	Single	4PXZ	2MeSADP	4PXZ-P2Y₁₂-2MeSADP
4.76	Single	4PY0	2MeSATP	4PY0-P2Y₁₂-2MeSATP
4.76	Single	5CXV	Tiotropium	5CXV-M₁-Tiotropium
4.76	Single	6ZG4	HTL0009936	6ZG4-M₁-HTL0009936
4.76	Single	7L1V	PubChem 155491009	7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76	Single	7XW9	TRH	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
4.76	Single	7XXI	2MeSADP	7XXI-P2Y₁₂-2MeSADP-Gi2/β1/γ2
4.76	Single	8DWC	Proenkephalin-A	8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.76	Single	8E9W	2-Deoxycytidine	8E9W-M₃-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.76	Single	8G05	6-OAU	8G05-GPR84-6-OAU-Gi1/β1/γ2
4.76	Single	8H0Q	Gastrin Releasing Peptide	8H0Q-BB₂-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76	Single	8JZ7	MK6892	8JZ7-HCA₂-MK6892-Gi1/β1/γ2
4.76	Single	8WRB	Lysophosphatidylserine	8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
4.76	Single	8Y6W	TUG-1375	8Y6W-FFA2-TUG-1375-4-CMTB-Gi1/β1/γ2
4.76	Single	9CM3	TUG-1375	9CM3-FFA2-TUG-1375-Compound 187-chim(NtGi1L-Gs-CtGq)/β1/γ2
4.76	Consensus	ffa2_on_gp	Orthosteric Ligand	8J22-FFA2-TUG-1375-Gi1/β1/γ2
4.76	Consensus	gi_amine	Orthosteric Ligand	gi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
4.76	Consensus	gi_muscarinic	Orthosteric Ligand	8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M₂-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M₄-Acetylcholine-Gi1/β1/γ2 7TRK-M₄-Iperoxo-Gi1/β1/γ2 7V6A-M₄-PubChem 9864275-Gi1/β1/γ2
4.76	Consensus	gi_p2y	Orthosteric Ligand	7XXI-P2Y₁₂-2MeSADP-Gi2/β1/γ2
4.76	Consensus	m1_off	Orthosteric Ligand	5CXV-M₁-Tiotropium
4.76	Consensus	m4_on	Orthosteric Ligand	7TRS-M₄-Acetylcholine-Gi1/β1/γ2 7V6A-M₄-PubChem 9864275-Gi1/β1/γ2 8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M₄-Iperoxo-Gi1/β1/γ2
4.76	Consensus	m4_on_gp	Orthosteric Ligand	7TRS-M₄-Acetylcholine-Gi1/β1/γ2 7V6A-M₄-PubChem 9864275-Gi1/β1/γ2 8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M₄-Iperoxo-Gi1/β1/γ2
4.76	Consensus	p2y12_on_gp	Orthosteric Ligand	7XXI-P2Y₁₂-2MeSADP-Gi2/β1/γ2
4.76	Consensus	trh_on	Orthosteric Ligand	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
4.76	Consensus	trh_on_gp	Orthosteric Ligand	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
4.55	Single	6RZ9	ONO-2770372	6RZ9-CysLT₂-ONO-2770372
4.55	Single	7D7M	Dinoprostone	7D7M-EP₄-Dinoprostone-Gs/β1/γ1
4.55	Single	7QVM	Oxytocin	7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
4.55	Single	7VGY	2-Iodomelatonin	7VGY-MT₁-2-Iodomelatonin-Gi1/β1/γ2
4.55	Single	7X1U	TRH	7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.55	Single	8E9X	2-Deoxycytidine	8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
4.55	Single	8E9Y	Clozapine-N-oxide	8E9Y-M₃-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.55	Single	8FX5	Xanomeline	8FX5-M₄-Xanomeline-Xanomeline-Gi1/β1/γ2
4.55	Single	8IJD	MK6892	8IJD-HCA₂-MK6892-Gi1/β1/γ2
4.55	Single	8J19	LY237	8J19-GPR84-LY237-Gi1/β1/γ2
4.55	Single	8XIO	L797591	8XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
4.55	Single	9M54	Neuropeptide VF	9M54-NPFF2-Neuropeptide VF-Gi1/β1/γ2
4.55	Consensus	cyslt2_off	Orthosteric Ligand	6RZ7-CysLT₂-ONO-2570366 6RZ8-CysLT₂-ONO-2080365 6RZ9-CysLT₂-ONO-2770372
4.35	Single	6RZ6	ONO-2570366	6RZ6-CysLT₂-ONO-2570366
4.35	Single	8J22	TUG-1375	8J22-FFA2-TUG-1375-Gi1/β1/γ2
4.35	Single	8SAI	1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine	8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
4.35	Single	9ITB	LPA	9ITB-LPA₆-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35	Single	9JH6	C20:0 Ceramide	9JH6-CysLT₂-C20:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35	Single	9MD1	Buspirone	9MD1-5-HT_1A-Buspirone-Gz/β1/γ2
4.17	Single	6RZ8	ONO-2080365	6RZ8-CysLT₂-ONO-2080365
4.17	Single	7WKD	TRH	7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17	Single	8DWG	Proenkephalin-A	8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.17	Single	8XBH	S3E-LysoPS	8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
4.17	Single	9J0I	UDP-Glucuronic acid	9J0I-P2Y₁₄-UDP-Glucuronic acid-Gi1/β1/γ2
4.17	Consensus	gi_nucleotide	Orthosteric Ligand	gi_adenosine gi_p2y
4.00	Single	8F7W	Dynorphin	8F7W-κ-Dynorphin-Gi1/β1/γ2
4.00	Single	9J0F	NADH	9J0F-P2Y₁₄-NADH-Gi1/β1/γ2
3.85	Single	7RYC	Oxytocin	7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.85	Single	7XOU	Cholecystokinin-8	7XOU-CCK_A-Cholecystokinin-8-Gs/β1/γ2
3.85	Single	8XGU	TAK448	8XGU-Kiss1-TAK448-Gi1/β1/γ2
3.85	Single	9K27	PrRP31	9K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
3.70	Single	7AD3	Alpha-factor mating pheromone	7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
3.70	Single	7DW9	AVP	7DW9-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
3.70	Single	7KH0	AVP	7KH0-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
3.70	Single	7W40	Bombesin	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/β1/γ2
3.70	Single	7YON	Peptide-YY(3-36)	7YON-Y₂-Peptide-YY(3-36)-Gi1/β1/γ2
3.70	Single	8IHF	MK6892	8IHF-HCA₂-MK6892-Gi1/β1/γ2
3.70	Single	8J6I	MK6892	8J6I-HCA₂-MK6892-Gi1/β1/γ2
3.70	Consensus	gs_vasop-oxy	Orthosteric Ligand	7DW9-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
3.70	Consensus	p2y_on_gp	Orthosteric Ligand	p2y1_on_gp p2y10_on_gp p2y12_on_gp
3.70	Consensus	v2_on	Orthosteric Ligand	7DW9-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
3.70	Consensus	v2_on_gp	Orthosteric Ligand	7DW9-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
3.70	Consensus	vasop-oxy_on	Orthosteric Ligand	v2_on
3.70	Consensus	vasop-oxy_on_gp	Orthosteric Ligand	v2_on_gp
3.57	Single	8XGO	TAK448	8XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
3.57	Single	8ZPS	PrRP20	8ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
3.45	Single	7W3Z	Gastrin Releasing Peptide	7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
3.45	Single	8H0P	NMB30	8H0P-BB₁-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
3.33	Single	7AD3	Alpha-factor mating pheromone	7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
3.33	Single	7QBC	Alpha-factor mating pheromone	7QBC-STE2-α-factor mating pheromone
3.33	Single	7YOO	Neuropeptide-Y	7YOO-Y₂-Neuropeptide-Y-Gi1/β1/γ2
3.33	Single	9K26	PrRP31	9K26-PrRP-PrRP31-Gi1/β1/γ2
3.33	Consensus	npy2_on	Orthosteric Ligand	7YOO-Y₂-Neuropeptide-Y-Gi1/β1/γ2
3.33	Consensus	npy2_on_gp	Orthosteric Ligand	7YOO-Y₂-Neuropeptide-Y-Gi1/β1/γ2
3.23	Single	7QBC	Alpha-factor mating pheromone	7QBC-STE2-α-factor mating pheromone
3.23	Single	7VGX	Neuropeptide-Y	7VGX-Y₁-Neuropeptide-Y-Gi1/β1/γ2
3.12	Single	8ZJE	TAK-448	8ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
3.12	Consensus	bb2_on	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
3.12	Consensus	bb2_on_gp	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
3.12	Consensus	bombesin_on	Orthosteric Ligand	bb2_on
3.12	Consensus	bombesin_on_gp	Orthosteric Ligand	bb2_on_gp
3.12	Consensus	gq_bombesin	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
2.94	Consensus	gs_peptide	Orthosteric Ligand	gs_cck gs_melanocortin gs_vasop-oxy
2.70	Consensus	mc2_on	Orthosteric Ligand	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
2.70	Consensus	mc2_on_gp	Orthosteric Ligand	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
2.33	Single	8GY7	Corticotropin	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1

PDB Summary
PDB	8IKH
Class	A
SubFamily	Lipid
Type	Cannabinoid
SubType	CB1
Species	Homo Sapiens
Ligand	-
Other Ligand(s)	Q2L
Protein Partners	Gi1/Beta1/Gamma1
PDB Resolution	3.3
Date	2024-06-05
D.O.I.	doi.org/10.1073/pnas.2321532121

Net Summary
I_min	2.42
Number of Linked Nodes	798
Number of Links	940
Number of Hubs	156
Number of Links mediated by Hubs	548
Number of Communities	31
Number of Nodes involved in Communities	212
Number of Links involved in Communities	291

Path Summary
Number Of Nodes in MetaPath	106
Number Of Links MetaPath	105
Number of Shortest Paths	700544
Length Of Smallest Path	3
Average Path Length	27.9792
Length of Longest Path	64
Minimum Path Strength	1.24
Average Path Strength	5.42351
Maximum Path Strength	21.6
Minimum Path Correlation	0.7
Average Path Correlation	0.978341
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	2.22222
Average % Of Corr. Nodes	46.7894
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	56.3547
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development
Gene Ontology	Biological Process	• multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • cannabinoid receptor activity • identical protein binding • cannabinoid signaling pathway • metabolic process • regulation of metabolic process • trans-synaptic signaling • trans-synaptic signaling by endocannabinoid • retrograde trans-synaptic signaling • cell-cell signaling • retrograde trans-synaptic signaling by endocannabinoid • synaptic signaling • trans-synaptic signaling by lipid • retrograde trans-synaptic signaling by lipid • multicellular organismal process • neuron recognition • cellular developmental process • cell projection organization • cell development • neuron projection development • neuron projection fasciculation • cellular component organization • neurogenesis • multicellular organism development • neuron differentiation • axonal fasciculation • cell differentiation • anatomical structure development • cell recognition • cellular component organization or biogenesis • system development • developmental process • plasma membrane bounded cell projection organization • nervous system development • axon development • generation of neurons • neuron development • inorganic ion homeostasis • intracellular calcium ion homeostasis • homeostatic process • calcium ion homeostasis • regulation of cytosolic calcium ion concentration • regulation of presynaptic cytosolic calcium ion concentration • cellular homeostasis • neuron cellular homeostasis • chemical homeostasis • intracellular monoatomic cation homeostasis • monoatomic ion homeostasis • intracellular chemical homeostasis • monoatomic cation homeostasis • intracellular monoatomic ion homeostasis • glucose homeostasis • carbohydrate homeostasis • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • cytoskeleton • membraneless organelle • intracellular membraneless organelle • actin cytoskeleton • presynapse • presynaptic membrane • plasma membrane region • synaptic membrane • membrane microdomain • membrane raft • growth cone • axon • distal axon • site of polarized growth • GABA-ergic synapse • glutamatergic synapse • mitochondrial membrane • mitochondrion • organelle outer membrane • organelle envelope • mitochondrial envelope • mitochondrial outer membrane • outer membrane • D2 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • response to peptide hormone • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cell cycle • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • midbody • nucleus • membrane-enclosed lumen • nucleolus • intracellular organelle lumen • organelle lumen • nuclear lumen • cell cortex • centrosome • microtubule organizing center • microtubule cytoskeleton • centriolar satellite • nucleoplasm • Golgi apparatus • endomembrane system • ciliary basal body
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	Q2L
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	Q2L
Name	3-[(1R)-1-(2-methoxyphenyl)-2-nitro-ethyl]-2-phenyl-1H-indole
Synonyms
Identifier
Formula	C23 H20 N2 O3
Molecular Weight	372.417
SMILES
PubChem	171393541
Formal Charge	0
Total Atoms	48
Total Chiral Atoms	1
Total Bonds	51
Total Aromatic Bonds	22


PDBsum	Open PDBsum Page
Chain	A
Protein	G Protein α Sub unit
UniProt	P63096
Sequence	>8IKH_Chain_A T L S A E D K A A V E R S K M I D R N L R E D G E K A A R E V K L L L L G A G E S G K S T I V K Q M K T G I V E T H F T F K D L H F K M F D V G G Q R S E R K K W I H C F E G V T A I I F C V A L S D Y D L V N R M H E S M K L F D S I C N N K W F T D T S I I L F L N K K D L F E E K I K K S P L T I C Y P E Y A G S N T Y E E A A A Y I Q C Q F E D L N K R K D T K E I Y T H F T C A T D T K N V Q F V F D A V T D V I I K N N L K D C G L F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	B
Protein	G Protein β Sub unit
UniProt	P62873
Sequence	>8IKH_Chain_B E L D Q L R Q E A E Q L K N Q I R D A R K D A T L S Q I T N N I D P V G R I Q M R T R R T L R G H L A K I Y A M H W G T D S R L L V S A S Q D G K L I I W D S Y T T N K V H A I P L R S S W V M T C A Y A P S G N Y V A C G G L D N I C S I Y N L K T R E G N V R V S R E L A G H T G Y L S C C R F L D D N Q I V T S S G D T T C A L W D I E T G Q Q T T T F T G T G D V M S L S L A P D T R L F V S G A C D A S A K L W D V R E G M C R Q T F T G E S D I N A I C F F P N G N A F A T G S D D A T C R L F D L R A D Q E L M T Y S H D N I I C G I T S V S F S K S G R L L L A G Y D D F N C N V W D A L K A D R A G V L A G H D N R V S C L G V T D D G M A V A T G S W D S F L K I W N Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	G
Protein	G Protein γ Sub unit
UniProt	P59768
Sequence	>8IKH_Chain_G A S I A Q A R K L V E Q L K M E A N I D R I K V S K A A A D L M A Y C E A H A K E D P L L T P V P P F R E Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	R
Protein	Receptor
UniProt	P21554
Sequence	>8IKH_Chain_R E C F M V L N P S Q Q L A I A V L S L T L G T F T V L E N L L V L C V I L H S R S L R C R P S Y H F I G S L A V A D L L G S V I F V Y S F I D F H R K D S R N V F L F K L G G V T A S F T A S V G S L F L T A I D R Y I S I H R P L A Y K R I V T R P K A V V A F C L M W T I A I V I A V L P L L G W N C I D E T Y L M F W I G V T S V L L L F I V Y A Y M Y I L W K A H S H A V R M I Q R G A R M D I R L A K T L V L I L V V L I I C W G P L L A I M V Y D V F G K M N K L I K T V F A F C S M L C L L N S T V N P I I Y A L R S K D L R H A F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7FEE	A	Lipid	Cannabinoid	CB₁	Homo sapiens	CP55940	ZCZ011	-	2.7	2022-06-15	doi.org/10.1038/s41589-022-01038-y
	7WV9	A	Lipid	Cannabinoid	CB₁	Homo sapiens	CP55940	ZCZ011	Gi2/β1/γ2	3.36	2022-06-15	doi.org/10.1038/s41589-022-01038-y
	7WV9 (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	CP55940	ZCZ011		3.36	2022-06-15	doi.org/10.1038/s41589-022-01038-y
	8IKH (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	-	Q2L		3.3	2024-06-05	doi.org/10.1073/pnas.2321532121
	8IKG	A	Lipid	Cannabinoid	CB₁	Homo sapiens	-	Q2B	Gi1/β1/γ1	3.4	2024-06-05	doi.org/10.1073/pnas.2321532121
	8IKG (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	-	Q2B		3.4	2024-06-05	doi.org/10.1073/pnas.2321532121
	6KQI	A	Lipid	Cannabinoid	CB₁	Homo sapiens	CP55940	Org27569	-	3.25	2019-10-23	doi.org/10.1038/s41589-019-0387-2
	8K8J	A	Lipid	Cannabinoid	CB₁	Homo sapiens	Fenofibrate	-	chim(Gs-CtGq)/β1/γ2	2.88	2024-02-14	doi.org/10.1002/advs.202306311
	8K8J (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	Fenofibrate	-		2.88	2024-02-14	doi.org/10.1002/advs.202306311
	5TGZ	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AM6538	-	-	2.8	2016-11-02	doi.org/10.1016/j.cell.2016.10.004
	6N4B	A	Lipid	Cannabinoid	CB₁	Homo sapiens	MDMB-Fubinaca	-	Gi1/β1/γ2	3	2019-01-30	doi.org/10.1016/j.cell.2018.11.040
	6N4B (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	MDMB-Fubinaca	-		3	2019-01-30	doi.org/10.1016/j.cell.2018.11.040
	6KPG	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AM841	-	Gi1/β1/γ2	3	2020-02-12	doi.org/10.1016/j.cell.2020.01.008
	6KPG (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AM841	-		3	2020-02-12	doi.org/10.1016/j.cell.2020.01.008
	7V3Z	A	Lipid	Cannabinoid	CB₁	Homo sapiens	CP55940	-	-	3.29	2021-11-24	doi.org/10.1021/jacs.1c06847
	5U09	A	Lipid	Cannabinoid	CB₁	Homo sapiens	Taranabant	-	-	2.6	2016-12-07	doi.org/10.1038/nature20613
	5XR8	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AM841	-	-	2.95	2017-07-12	doi.org/10.1038/nature23272
	5XRA	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AM11542	-	-	2.8	2017-07-12	doi.org/10.1038/nature23272
	8GHV	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AMG315	-	Gi1/β1/γ2	2.8	2023-05-24	doi.org/10.1038/s41467-023-37864-4
	8GHV (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AMG315	-		2.8	2023-05-24	doi.org/10.1038/s41467-023-37864-4
	9B9Z	A	Lipid	Cannabinoid	CB₁	Homo sapiens	A1AKO	-	-	3.3	2024-11-20	doi.org/10.1038/s41467-024-54206-0
	9BA0	A	Lipid	Cannabinoid	CB₁	Homo sapiens	A1AKN	-	-	3.13	2024-11-20	doi.org/10.1038/s41467-024-54206-0
	9B9Y	A	Lipid	Cannabinoid	CB₁	Homo sapiens	7DY	-	-	3.5	2024-11-20	doi.org/10.1038/s41467-024-54206-0
	9B54	A	Lipid	Cannabinoid	CB₁	Homo sapiens	A1AIW	-	Gi1/β1/γ2	2.86	2025-03-05	doi.org/10.1038/s41586-025-08618-7
	9B54 (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	A1AIW	-		2.86	2025-03-05	doi.org/10.1038/s41586-025-08618-7
	9B65	A	Lipid	Cannabinoid	CB₁	Homo sapiens	KCA	-	Gi1/β1/γ2	3.03	2025-03-05	doi.org/10.1038/s41586-025-08618-7
	9B65 (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	KCA	-		3.03	2025-03-05	doi.org/10.1038/s41586-025-08618-7
	8WRZ	A	Lipid	Cannabinoid	CB₁	Homo sapiens	PubChem 102336704	-	Arrestin2	3.6	2024-02-28	doi.org/10.1093/procel/pwad055
	9ERX	A	Lipid	Cannabinoid	CB₁	Homo sapiens	D9-THC analog	-	Gi1/β1/γ2	2.9	2024-06-26	doi.org/10.21203/rs.3.rs-4277209/v1
	9ERX (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	D9-THC analog	-		2.9	2024-06-26	doi.org/10.21203/rs.3.rs-4277209/v1
	8WU1	A	Lipid	Cannabinoid	CB₁	Homo sapiens	PubChem 119025665	-	Arrestin2	3.2	2024-03-20	doi.org/10.1016/j.cell.2023.11.017
	9DGI	A	Lipid	Cannabinoid	CB₁	Homo sapiens	Z8526711350	-	-	3.35	2025-04-30	doi.org/10.1038/s41467-025-57136-7
	9EGO	A	Lipid	Cannabinoid	CB₁	Homo sapiens	YVF	-	Gi1/β1/γ2	3.2	2025-04-30	doi.org/10.1038/s41467-025-57136-7
	9EGO (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	YVF	-		3.2	2025-04-30	doi.org/10.1038/s41467-025-57136-7
	8GAG	A	Lipid	Cannabinoid	CB₁	Homo sapiens	PubChem 170838490	-	Gi1/β1/γ2	3.3	2024-02-28	To be published
	8GAG (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	PubChem 170838490	-		3.3	2024-02-28	To be published

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