Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
1G.HN.29 1.45793402
2G.S1.06 4.79423458
3G.s1h1.04 4.57666409
4G.H1.01 4.86254459
5G.S2.06 5.106409
6G.S2.08 3.72504496
7G.S3.03 5.99247698
8G.S3.04 8.1277417
9G.S3.06 7.69804517
10G.s3h2.03 3.95254519
11G.H2.01 4.02595419
12G.H2.06 5.61414519
13G.H2.07 5.66375619
14G.h2s4.01 7.58334519
15G.S4.02 3.92219418
16G.S4.03 3.36985457
17G.S4.07 6.47332408
18G.s4h3.04 4.91666408
19G.H3.01 4.11734509
20G.H3.09 4.485616139
21G.H3.13 9.022875136
22G.H3.17 8.02597615
23G.S5.05 4.07155659
24G.S5.07 3.44789559
25G.HG.03 3.60665406
26G.hgh4.05 11.1388406
27G.hgh4.11 3.36247405
28G.hgh4.20 4.07517403
29G.hgh4.21 5.3045404
30G.H4.03 2.73036404
31G.H4.08 4.45784403
32G.H4.10 7.72803507
33G.H4.15 6.85637408
34G.h4s6.12 3.93333502
35G.h4s6.20 2.93326404
36G.S6.02 8.20342408
37G.S6.05 8.816684145
38G.s6h5.01 5.26191459
39G.s6h5.05 5.18594459
40G.H5.03 5.52065459
41G.H5.05 4.37629495
42G.H5.06 5.88888454
43G.H5.08 4.8138798
44G.H5.17 2.24023505
45G.H5.20 2.53463408
46G.H5.23 5.76465504
47b.1x1 1.1816404
48b.1x11 2.19078408
49b.lh12x2 4.58299408
50b.h2x1 3.97532405
51b.lhb1x3 2.39582502
52b.b1x4 3.135074167
53b.l1x3 9.10739579
54b.l1x6 8.23423519
55b.b2x1 6.63806518
56b.b2x3 3.73895476
57b.b2x5 6.65834677
58b.l3x2 6.54328409
59b.b4x6 9.54656679
60b.b5x2 5.72539407
61b.b5x3 6.09953679
62b.b5x5 5.265444175
63b.b5x7 5.86312407
64b.l5x1 4.578385118
65b.l5x5 8.04195619
66b.b6x1 4.03858419
67b.b6x5 4.26082606
68b.l6x5 5.741424124
69b.b7x1 5.1575124
70b.b7x4 3.458734118
71b.b8x4 5.317745116
72b.l8x3 3.068984183
73b.l8x5 3.766034183
74b.b9x3 4.02646406
75b.b9x4 6.52335409
76b.l9x3 6.86647519
77b.l9x6 5.63254618
78b.b10x5 4.77669509
79b.l10x1 3.57172403
80b.b11x4 4.99042419
81b.l11x2 7.5134419
82b.b12x6 8.50222618
83b.b13x7 7.60368547
84b.l13x3 7.1695649
85b.l13x6 5.12057519
86b.l13x7 4.39986449
87b.b14x3 4.57434445
88b.b15x1 6.37429549
89b.l15x2 6.01851449
90b.b16x4 9.9613446
91b.b16x6 8.39945648
92b.b17x5 7.04162437
93b.b17x7 8.66287438
94b.l17x3 8.50324639
95b.l17x6 7.53833419
96b.b18x3 5.07865438
97b.b18x5 4.77891405
98b.l18x1 6.007757106
99b.l18x2 5.67994107
100b.b19x2 6.65314636
101b.b19x4 5.69268438
102b.l19x2 6.14709539
103b.b20x4 8.0102638
104b.b20x6 7.62356536
105b.b20x7 4.56849409
106b.l20x2 7.1072409
107b.b21x1 8.65268437
108b.b21x2 2.92112406
109b.b21x5 5.40344404
110b.b21x7 5.62696605
111b.l21x2 5.01241404
112b.b22x5 5.820585107
113b.l22x5 6.630415159
114b.b23x6 6.04281717
115b.l23x1 5.50677516
116b.b24x4 6.92526416
117b.b24x6 6.26126418
118b.l25x3 8.1785569
119b.l25x6 11.8122518
120b.l28x1 9.47695719
121b.l28x2 7.87377469
122b.b28x3 3.89176407
123b.b28x4 6.10515566
124b.b28x6 8.87404569
125g.h1x1 0.649188402
126g.l1x4 4.89263408
127g.h2x11 8.119714106
128g.ctx3 6.22248569
129g.ctx6 3.17297406
130g.ctx14 4.65602409
131g.ctx16 4.202896168
1321x31 1.64686401
1331x59 1.75046405
1341x60 2.65831606
1352x40 3.79747409
1362x42 4.72457608
1372x46 4.26158489
1382x50 5.54759589
139E1x50 6.49756428
140E1x52 3.47821706
1413x30 2.54901406
1423x33 4.95711426
1433x37 3.41597427
1443x50 5.31661589
1453x51 6.585034208
1463x55 5.387914207
1474x56 2.10633426
148E2 9.730741623
149E2x52 4.32047425
1505x36 2.45194425
1515x46 3.01375425
1525x58 5.1903689
1536x44 4.95724409
1546x48 5.35934728
1556x51 5.14613527
1566x52 6.2546427
157E3 4.172261123
1587x38 4.36511426
1597x49 4.98285489
1607x53 3.91158689
1618x50 3.60586509
162Lig 8.046372620
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1G.HN.40 b.b5x2 14.52967.41847NoYes077
2G.HN.40 b.b5x3 14.74084.86717NoYes079
3b.b3x6 b.l1x3 25.369811.4953NoYes099
4b.b3x6 b.l3x2 25.43747.886NoYes099
5b.b4x6 b.l1x3 17.47325.15953YesYes799
6b.l1x4 b.l3x2 26.41288.63664NoYes069
7G.HN.51 b.l1x4 1005.54042NoNo046
8G.hns1.01 b.l1x4 76.98433.11883NoNo046
9G.S1.03 G.hns1.01 76.978211.9NoNo094
10G.S1.03 G.S3.06 76.97524.43431NoYes097
11G.HN.51 G.hns1.02 99.91153.71853NoNo044
124x38 G.hns1.02 99.65992.92989NoNo084
134x38 4x41 99.53132.27664NoNo087
144x41 4x45 99.43212.47211NoNo076
152x42 4x45 99.38644.13878YesNo086
162x42 3x49 19.17789.46225YesNo089
173x49 G.H5.23 18.95395.48092NoYes094
183x53 G.H5.23 25.85275.057NoYes084
193x53 G.H5.19 25.68434.26592NoNo088
20G.H5.15 G.H5.19 25.51583.31583NoNo088
21G.H5.15 G.S1.02 25.20052.57789NoNo086
22G.S1.02 G.S3.03 24.86257.42506NoYes068
23G.S1.04 G.S3.03 19.57093.51828NoYes078
24G.S1.04 G.S4.03 19.39873.76972NoYes077
25G.S3.06 G.h2s4.01 52.65843.12039YesYes179
26b.b3x2 b.b4x6 11.59032.97775NoYes759
27b.b26x2 b.b2x3 10.60184.79742NoYes076
28b.b26x1 b.b26x2 10.53523.04344NoNo097
29b.b26x1 b.l28x1 10.59214.31683NoYes099
30G.H3.17 b.l28x1 14.05473.95483YesYes159
31G.S4.03 G.S5.05 17.22783.04517YesYes579
32b.b2x1 b.l28x1 32.9787.18656YesYes189
33b.b2x1 b.b6x1 21.10763.01339YesYes189
34b.b6x1 b.l9x6 21.21075.706YesYes198
35G.S3.06 b.l5x5 24.74416.0741YesYes179
36b.l1x6 b.l28x1 12.248917.9551YesYes199
37b.l1x6 b.l3x1 12.42076.98317YesNo199
38b.l3x1 b.l5x5 24.88477.98386NoYes199
39b.b2x1 b.l3x1 12.48411.7109YesNo189
40G.H2.07 G.h2s4.01 52.74264.11514YesYes199
41G.H2.07 b.l9x6 50.04194.49922YesYes198
42G.H2.06 b.l17x6 30.46087.86622YesYes199
43G.H2.06 b.l9x6 61.05513.19642YesYes198
44G.H2.04 G.H2.07 27.13276.60547NoYes099
45G.H2.04 G.H3.08 26.77148.43125NoNo098
46G.H2.06 b.b18x1 30.35544.65308YesNo099
47b.l25x6 b.l28x1 22.211720.6742YesYes189
48G.H3.08 G.S4.04 26.66995.20044NoNo089
49G.H3.09 G.S4.04 16.5925.58806YesNo099
50G.H3.06 G.H4.15 10.21978.274NoYes068
51G.H3.17 b.l23x1 15.60485.06697YesYes156
52b.l23x1 b.l25x6 13.487413.2976YesYes168
53G.S5.04 G.S5.06 13.12754.16758NoNo098
54G.S5.06 G.S6.05 12.72116.02256NoYes085
552x42 3x46 79.18183.71667YesNo089
56b.l17x6 b.l19x1 31.3135.48411YesNo099
57b.l17x5 b.l19x1 61.38953.90422NoNo069
58b.l17x5 b.l19x2 61.18553.40519NoYes069
59b.l17x3 b.l19x2 41.85054.70433YesYes399
60b.b19x4 b.l17x3 22.72117.78081YesYes389
61b.b19x4 b.b20x6 17.4066.12747YesYes386
62b.b17x7 b.b20x6 43.539511.3728YesYes386
63b.b17x7 b.b21x1 35.58964.68797YesYes387
64b.1x19 b.b21x1 32.30769.28331NoYes067
65b.1x15 b.1x19 26.31073.94936NoNo076
66b.1x12 b.1x15 24.97672.746NoNo067
67b.1x12 g.h1x11 14.9052.66725NoNo069
68b.1x11 g.h1x11 12.22733.43572YesNo089
69b.b18x1 b.l19x1 30.28069.39142NoNo099
70b.b20x4 b.l17x3 18.279616.4926YesYes389
71b.b20x4 b.b20x6 34.7934.6615YesYes386
72b.b20x2 b.l19x2 18.70668.46775NoYes069
73b.b20x2 b.b20x4 18.2754.76483NoYes068
74b.b5x2 b.l4x3 11.91389.64764YesNo076
75b.b4x7 b.l4x3 11.72089.12895NoNo086
76b.b4x7 b.l2x5 11.671914.2458NoNo085
77b.l2x5 b.l4x2 12.666122.3127NoNo054
78b.l4x2 g.ctx16 11.66425.89706NoYes048
79b.l2x3 b.l2x5 23.63293.06822NoNo085
80b.b3x1 b.l2x3 23.37595.66314NoNo058
81b.b3x1 b.b6x5 23.11884.86069NoYes056
82b.b2x4 b.b6x5 13.25562.62811NoYes066
83b.b10x4 b.b2x4 12.993611.1657NoNo066
84b.b2x5 b.l4x1 13.91064.78622YesNo075
85b.l4x1 g.ctx16 13.79644.13781NoYes058
86b.b16x5 b.l14x6 12.48645.58561NoNo053
87b.b16x7 b.l14x6 10.92613.14011NoNo093
88b.l21x7 b.l23x1 27.75983.51814NoYes156
89b.b23x6 b.l21x7 25.89863.0495YesNo175
90b.b23x6 b.b24x6 21.10696.94814YesYes178
91b.b21x7 b.b24x6 20.44338.63572YesYes058
923x36 Lig 37.84753.28183NoYes270
933x36 6x48 38.07624.44933NoYes278
946x44 6x48 43.22478.98431YesYes098
953x43 6x44 39.03613.21772NoYes089
963x43 7x53 39.0764.26369NoYes089
973x46 7x53 73.82563.60389NoYes899
986x51 Lig 37.9966.872YesYes270
996x48 6x51 38.39583.13067YesYes287
1006x48 7x45 39.10257.59581YesNo089
1017x45 7x49 39.30675.11419NoYes099
1027x49 7x53 41.46064.19322YesYes899
1032x63 E1x50 11.36084.06767NoYes258
1042x63 Lig 11.88764.54633NoYes250
1051x39 2x57 10.55273.85503NoNo077
1062x57 7x42 14.77036.899NoNo077
107E2 Lig 12.415816.5025YesYes230
1083x33 Lig 10.93095.55617YesYes260
1093x50 G.H5.23 11.64436.6595YesYes094
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
2x563x324.713530NoNo7721
2x607x382.9222NoYes7611
2x607x423.216332NoNo7712
2x60Lig5.87522NoYes7010
2x63E1x504.067672NoYes5812
2x63Lig4.546332NoYes5010
2x647x353.4382NoNo6512
2x64Lig3.128692NoYes6010
E1x49E26.917782NoYes4321
3x22E26.030332NoYes4321
3x294x657.097442NoNo6612
3x29Lig6.303612NoYes6010
3x32Lig5.411422NoYes7010
3x334x573.723032YesNo6812
3x33Lig5.556172YesYes6010
3x366x484.449332NoYes7812
3x36Lig3.281832NoYes7010
4x615x392.935782NoNo7812
4x61Lig3.903222NoYes7010
4x64E2x523.449562NoYes5521
4x64E26.446472NoYes5321
4x65E2x524.749330NoYes6521
E2E245.93872YesYes3311
E2E2x518.424672YesNo3411
E2Lig16.50252YesYes3010
E2x51Lig6.721562NoYes4010
E2E2x523.5372YesYes3511
E2x52Lig5.5462YesYes5010
5x35E23.254112NoYes4321
5x36E25.660312YesYes5321
6x486x513.130672YesYes8721
6x486x523.134362YesYes8722
6x487x415.160722YesNo8722
6x516x525.230442YesYes7712
6x516x556.712282YesNo7711
6x517x413.785282YesNo7712
6x55Lig8.909832NoYes7010
6x57E34.893610NoYes5321
6x58E34.206472NoYes4311
6x58Lig8.586612NoYes4010
6x61E33.993310NoYes4321
E3E39.848172YesYes3311
E3Lig7.4692YesYes3010
7x347x383.451392NoYes5611
7x34Lig12.21592NoYes5010
7x387x423.642332YesNo6712
3x334x617.124442YesNo6711
6x51Lig6.8722YesYes7010
6x547x346.123640NoNo5521
7x38Lig7.444722YesYes6010
LigNT2.895692YesNo0301
3x333x373.424812YesYes6712
7x27Lig2.962780NoYes0010
7x31Lig8.135560NoYes3010
7x30E32.921110NoYes0321
2x67Lig2.802080NoYes4010
E1E22.344892NoYes0321
5x34E21.867440NoYes2321
7x26E31.489780NoYes0321
1x23E21.068670NoYes0321
5x29E20.8760NoYes0321
1x21E20.6260NoYes0321
7x24Lig0.6174440NoYes0010
1x24Lig0.6053332NoYes0010
2x68Lig0.5906670NoYes0010
7x23E30.5703332NoYes0321
7x25E30.4372220NoYes0321
1x241x250.3396672NoNo0012
5x28E20.2583330NoYes0321
6x64E30.2176670NoYes0321

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
84.62Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
65.52Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
63.33Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
62.96Consensusnmur_onOrthosteric Ligandnmur1_on nmur2_on
60.71Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
60.71Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
60.71Consensusgs_neuromedinOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
60.00Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
59.26Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
59.26Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
57.58Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
57.14Consensusnmur2_onOrthosteric Ligand7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
56.67Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
55.56Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
55.56Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
55.56Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
54.84Single6IGLIRL16206IGL-ETB-IRL1620
54.84Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
54.17Consensuscck_onOrthosteric Ligandccka_on cckb_on
53.85Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2 8I95-C3aB-EP54-Go/&β;1/&γ;2
53.85Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
53.85Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
53.57Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
53.57Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
53.57Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
53.33Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
53.33Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
53.33Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
53.33Consensusgi_neuromedinOrthosteric Ligand7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
53.33Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
53.12Single6IGKEndothelin-36IGK-ETB-Endothelin-3
52.94Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
52.94Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
52.00Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
51.85Single7F8XNN90567F8X-CCKA-NN9056
51.85Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
51.72Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
51.72Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
51.61Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
50.00Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
50.00Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
50.00Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
50.00Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
50.00Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
50.00Consensusalpha1_offOrthosteric Ligandalpha1a_off alpha1b_off
50.00Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
50.00Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
50.00Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
50.00Consensusgs_orexinOrthosteric Ligand7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
50.00Consensusorexin_onOrthosteric Ligandox2_on
48.57Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
48.48Single5GLHEndothelin-15GLH-ETB-Endothelin-1
48.39Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
48.39Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
48.39Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
48.39Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
48.28Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1
48.28Consensusangiotensin_onOrthosteric Ligandat1_on
48.28Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
48.15Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
48.15Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
48.15Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
48.15Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
48.15Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
46.88Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
46.88Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
46.88Consensusendothelin_onOrthosteric Ligandetb_on eta_on
46.67Single6JODAngiotensin II6JOD-AT2-Angiotensin II
46.67Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
46.67Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
46.67Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
46.43Single4XT1Fractalkine4XT1-US28-Fractalkine
46.43Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
46.43Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
46.43Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
46.43Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
46.43Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
46.43Consensusnmur1_onOrthosteric Ligand7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
46.43Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
46.43Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
46.15Single4XEENeurotensin4XEE-NTS1-Neurotensin
46.15Single4XESNeurotensin4XES-NTS1-Neurotensin
46.15Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
46.15Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
46.15Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
46.15Single8J6DEP1418J6D-C3aB-EP141-Go/&β;1/&γ;2
46.15Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
46.15Consensusdp_offOrthosteric Liganddp2_off
45.45Single7VGXNeuropeptide Y7VGX-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
45.45Single8FEGPRD_0025178FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
45.16Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
45.16Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
45.16Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
45.16Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
45.16Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
45.16Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
44.83Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
44.83Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
44.83Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
44.83Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
44.83Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
44.83Consensuscx3cr_onOrthosteric Ligandcx3cr1_on
44.44Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2
44.44Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
44.44Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
44.44Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
44.44Consensuscckb_onOrthosteric Ligand7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
44.44Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
44.44Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
44.12Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
44.12Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
44.00Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
44.00Single8JPCNeurotensin 8-138JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
43.75Single4XT3Fractalkine4XT3-US28-Fractalkine
43.75Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
43.75Consensusbb1_onOrthosteric Ligand8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
43.75Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
43.75Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
43.33Single3OE0CVX153OE0-CXCR4-CVX15
43.33Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
43.33Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
43.33Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;2
43.33Consensuscx3cr1_onOrthosteric Ligand7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
43.33Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
43.33Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
42.86Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
42.86Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
42.86Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
42.86Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
42.86Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
42.86Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
42.86Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
42.86Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
42.86Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
42.86Consensusgs_bombesinOrthosteric Ligand8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
42.86Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
42.86Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
42.42Consensusetb_onOrthosteric Ligand8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
42.31Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
42.31Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
42.31Single7XOWGastrin7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
42.31Single7XOXCholecystokinin-87XOX-CCKB-Cholecystokinin-8-Gq/&β;1/&γ;2
42.31Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
42.31Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
42.31Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
42.31Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
42.31Consensusgs_compl-peptideOrthosteric Ligand8I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
41.94Single7C61Ergotamine7C61-5-HT1B-Ergotamine
41.94Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
41.94Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
41.94Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
41.94Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
41.94Consensusgi_somatostatinOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
41.67Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
41.38Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
41.38Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
41.38Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
41.38Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
41.38Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
41.38Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
41.38Consensussst2_onOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
41.38Consensussst_onOrthosteric Ligandsst2_on sst4_on
41.18Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
41.18Single8IY6Endothelin-18IY6-ETB-Endothelin-1
41.18Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
41.18Consensusgs_endothelinOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
40.74Single4GRVNeurotensin 8-134GRV-NTS1-Neurotensin 8-13
40.74Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
40.74Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
40.74Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/&β;1/&γ;2
40.74Single6YVRNTS8-136YVR-NTS1-NTS8-13
40.74Single7Y66BM2137Y66-C5a1-BM213-Gi1/&β;1/&γ;2
40.74Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
40.74Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2
40.74Single8I95EP548I95-C3aB-EP54-Go/&β;1/&γ;2
40.74Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2
40.74Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2
40.74Consensuschemokine_offOrthosteric Ligandcxcr_off
40.74Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
40.74Consensuscxcr_offOrthosteric Ligandcxcr4_off
40.74Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
40.74Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
40.74Consensuspeptide_offOrthosteric Ligandopioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
40.62Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
40.62Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
40.62Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
40.62Consensusbombesin_onOrthosteric Ligandbb2_on bb1_on
40.62Consensusgs_melanocortinOrthosteric Ligand7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2
40.00Single3QAKUK-4320973QAK-A2A-UK-432097
40.00Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
40.00Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
40.00Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
40.00Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
40.00Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
40.00Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
40.00Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
40.00Consensusgi_hcaOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
40.00Consensusgi_hcarOrthosteric Ligandgi_hca
40.00Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
40.00Consensushca2_onOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
39.39Single7SK3CXCL127SK3-ACKR3-CXCL12
39.39Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
39.29Single4BUONeurotensin4BUO-NTS1-Neurotensin
39.29Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
39.29Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
39.29Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
39.29Single7EZCUKA7EZC-A2A-UKA
39.29Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
39.29Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
39.29Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
39.29Consensusc5a1_off_ortoalloOrthosteric Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
39.29Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
38.89Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
38.89Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
38.89Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
38.71Single5WF5UK-4320975WF5-A2A-UK-432097
38.71Single7F4DAlpha-MSH7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
38.71Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
38.71Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
38.71Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
38.71Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
38.46Single5N2SPSB365N2S-A1-PSB36
38.46Single6D26Fevipiprant6D26-DP2-Fevipiprant
38.46Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
38.46Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
38.46Single7CFNINT-7777CFN-GPBA-INT-777-Gs/&β;1/&γ;2
38.46Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
38.24Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
38.24Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
38.24Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
38.10Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
37.93Single4UG2CGS216804UG2-A2A-CGS21680
37.93Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
37.93Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
37.93Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
37.93Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
37.93Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
37.93Single7XN9L-054,5227XN9-SST2-L-054,522
37.93Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
37.93Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
37.93Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
37.93Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
37.93Consensuslpl_offOrthosteric Ligands1p_off lpa_off
37.93Consensuslpl_onOrthosteric Ligands1p_on lpa_on
37.93Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
37.50Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
37.50Single8GNGIstradefylline8GNG-A2A-Istradefylline
37.50Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
37.50Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
37.50Consensusm2_on_alloOther Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
37.04Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
37.04Single4BV0Neurotensin4BV0-NTS1-Neurotensin
37.04Single4RWADIPP-NH24RWA-δ-DIPP-NH2
37.04Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
37.04Single6OS1TRV0266OS1-AT1-TRV026
37.04Single7JVPSKF839597JVP-D1-SKF83959-Gs/&β;1/&γ;2
37.04Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1
37.04Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/&β;1/&γ;1
37.04Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2
37.04Single8E0GBU728E0G-μ-BU72
37.04Single8FMZNeurotensin/neuromedin N8FMZ-NTS1-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
37.04Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
37.04Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2
37.04Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/&β;1/&γ;2
36.67Single4IARErgotamine4IAR-5-HT1B-Ergotamine
36.67Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
36.67Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
36.67Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
36.67Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
36.67Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
36.67Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
36.67Single8GHVPubChem 1459649038GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
36.67Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
36.67Consensusfpr-alx_onOrthosteric Ligandfpr1-alx_on fpr2-alx_on
36.67Consensusmop_offOrthosteric Ligand7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
36.36Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
36.36Single7KH0Acyclovir triphosphate7KH0-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
36.36Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
36.36Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
36.36Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
36.36Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
36.36Consensusbk1_onOrthosteric Ligand7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
36.36Consensusgs_bradykininOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
36.00Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
36.00Single7XJJGalanin7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
36.00Single7XOVSR1461317XOV-CCKA-SR146131-Gs/&β;1/&γ;2
36.00Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
36.00Single8JIMMMF8JIM-HCA2-MMF-Gi1/&β;1/&γ;2
36.00Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
36.00Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
36.00Consensusgo_galaninOrthosteric Ligand7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
36.00Consensush3_on_alloOrthosteric Ligand7F61-H3-PF-03654746-Cholesterol
36.00Consensusox2_offOrthosteric Ligand6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant
35.71Single6MXTSalmeterol6MXT-β2-Salmeterol
35.71Single6OS2TRV0266OS2-AT1-TRV026
35.71Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
35.71Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
35.71Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
35.71Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
35.71Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
35.71Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.71Single7Y24Octreotide7Y24-SST2-Octreotide-Go/&β;1/&γ;2
35.71Single8JJLOlodaterol8JJL-β2-Olodaterol
35.71Single8JPBNeurotensin 8-138JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
35.71Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.48Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
35.48Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
35.48Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
35.48Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
35.48Single7SK5CXCL127SK5-ACKR3-CXCL12
35.48Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
35.48Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
35.48Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
35.48Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
35.29Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
35.29Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
34.62Single6D27CAY104716D27-DP2-CAY10471
34.62Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
34.62Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/&β;1/&γ;2
34.62Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
34.62Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/&β;1/&γ;2
34.62Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
34.62Single8K5DGSK2560738K5D-HCA2-GSK256073
34.62Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
34.62Consensuscck_offOrthosteric Ligandccka_off
34.62Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
34.62Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
34.62Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
34.48Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
34.48Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
34.48Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
34.48Single6DDFDamgo6DDF-μ-Damgo-Gi1/&β;1/&γ;2
34.48Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
34.48Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
34.48Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
34.48Consensusgi_neurotensinOrthosteric Ligand7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
34.48Consensusgs_galaninOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
34.48Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
34.38Single6PT2KGCHM076PT2-δ-KGCHM07
34.38Single6W25SHU91196W25-MC4-SHU9119-Ca
34.38Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
34.38Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
34.38Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
34.38Consensusgi_formylpeptideOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
34.29Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Single3OE9IT1t3OE9-CXCR4-IT1t
33.33Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
33.33Single5C1MBU725C1M-μ-BU72
33.33Single5N2RPubChem 92460631; psb365N2R-A2A-PubChem 92460631; psb36-Na
33.33Single5WF6UK-4320975WF6-A2A-UK-432097
33.33Single5ZTYAM102575ZTY-CB2-AM10257
33.33Single6DDEDamgo6DDE-μ-Damgo-Gi1/&β;1/&γ;2
33.33Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
33.33Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
33.33Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
33.33Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
33.33Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
33.33Single7CKXA776367CKX-D1-A77636-Gs/&β;1/&γ;2
33.33Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
33.33Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
33.33Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
33.33Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
33.33Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
33.33Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
33.33Single7XY6PubChem 117178317XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Single8DZQmomSalB8DZQ-κ-momSalB-Go/&β;1/&γ;2
33.33Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
33.33Single8GNEKW-63568GNE-A2A-KW-6356-Na
33.33Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
33.33Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
33.33Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
33.33Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Consensusa1_on_alloOrthosteric Ligand7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
33.33Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
33.33Consensuscb2_onOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
33.33Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRR-D1-Rotigotine-Gs/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
33.33Consensusfpr2-alx_onOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
33.33Consensusgo_opioidOrthosteric Ligand8DZQ-κ-momSalB-Go/&β;1/&γ;2
33.33Consensusgs_sstOrthosteric Ligand7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
32.43Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
32.43Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
32.35Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
32.35Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
32.35Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
32.26Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
32.26Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
32.26Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
32.26Single8G59TUG-8918G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
32.14Single3SN6BI1671073SN6-β2-BI167107-Gs/&β;1/&γ;2
32.14Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
32.14Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
32.14Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
32.14Single6NI3BI1671076NI3-β2-BI167107-Gs/&β;1/&γ;2
32.14Single6TQ7SB-3348676TQ7-OX1-SB-334867
32.14Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
32.14Single7B6WCyclazosin7B6W-α1b-Cyclazosin
32.14Single7CKYPW04647CKY-D1-PW0464-Gs/&β;1/&γ;2
32.14Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
32.14Single7EW7PubChem 40774607EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
32.14Single7F1TMIP-1a7F1T-CCR5-MIP-1a
32.14Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
32.14Single7JV5SKF812977JV5-D1-SKF81297-Gs/&β;1/&γ;2
32.14Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
32.14Single7TUYGSK682753A7TUY-GPR183-GSK682753A
32.14Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
32.14Single7WV9PubMed 1048957WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
32.14Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
32.14Single8DZPmomSalB8DZP-κ-momSalB-Gi1/&β;1/&γ;2
32.14Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
32.14Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
32.14Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
32.14Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2
32.14Consensus5ht1b_onOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
32.14Consensusalpha1b_offOrthosteric Ligand7B6W-α1b-Cyclazosin
32.14Consensusffa4_onOrthosteric Ligand8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
32.14Consensusgi_dopamineOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
32.14Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2
32.14Consensusnts1_on_alloOrthosteric Ligand8JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
32.14Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
32.14Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
32.00Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
32.00Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
32.00Single7F8ULintitript7F8U-CCKA-Lintitript
32.00Single7F8YDevazepide7F8Y-CCKA-Devazepide
32.00Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
32.00Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
32.00Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
32.00Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
32.00Single7XRRLemborexant7XRR-OX2-Lemborexant
32.00Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
32.00Consensusgi_nucleotideOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
32.00Consensusorexin_offOrthosteric Ligandox2_off ox1_off
31.43Single6FJ3PTH6FJ3-PTH1-PTH
31.43Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
31.25Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
31.25Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/&β;1/&γ;2
31.25Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
31.03Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
31.03Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
31.03Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/&β;1/&γ;2
31.03Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
31.03Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
31.03Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
31.03Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
31.03Single7WCNAR2314537WCN-GPR119-AR231453-Gs/&β;1/&γ;2
31.03Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.03Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
31.03Single7YITNalfurafine7YIT-κ-Nalfurafine
31.03Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
31.03Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
31.03Single8JWYPubChem 1684517108JWY-A2A-PubChem 168451710
31.03Single8JWZAB9288JWZ-A2A-AB928-Na
31.03Single8WU1KCA8WU1-CB1-KCA-Arrestin1
31.03Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
31.03Consensuscannabinoid_onOrthosteric Ligandcb1_on cb2_on
31.03Consensuscb1_onOrthosteric Ligand8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
31.03Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
31.03Consensusgi_cannabinoidOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
31.03Consensusgo_5htOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
31.03Consensusgpr119_onOrthosteric Ligand7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
31.03Consensusgs_bileacidOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
31.03Consensusgs_steroidOrthosteric Ligandgs_bileacid
31.03Consensusgs_trhOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
31.03Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
31.03Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
31.03Consensusopioid_offOrthosteric Ligandkop_off mop_off nop_off dop_off
31.03Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
31.03Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
30.77Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
30.77Single4ZJCSB-6740424ZJC-OX1-SB-674042
30.77Single5K2BZM2413855K2B-A2A-ZM241385-Na
30.77Single5NLXZM2413855NLX-A2A-ZM241385-Na
30.77Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
30.77Single6MH8ZM2413856MH8-A2A-ZM241385
30.77Single6V9SGTPL114036V9S-OX1-GTPL11403
30.77Single7AROLUF58337ARO-A2A-LUF5833-Na
30.77Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
30.77Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
30.77Single8GURPubChem 1048958GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2
30.77Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
30.77Single8JERAcipimox8JER-HCA2-Acipimox-Go/&β;1/&γ;2
30.77Single8K5CAcipimox8K5C-HCA2-Acipimox
30.77Single8UO2Epinephrine8UO2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
30.77Consensuscxcr_onOrthosteric Ligandcxcr1_on cxcr2_on
30.77Consensusgnrh_offOrthosteric Ligandgnrh1_off
30.77Consensushca_onOrthosteric Ligandhca2_on hca3_on
30.77Consensushcar_onOrthosteric Ligandhca_on
30.77Consensusox1_offOrthosteric Ligand6TOT-OX1-Lemborexant 6TP4-OX1-ACT-462206 6TP6-OX1-Filorexant 6V9S-OX1-GTPL11403 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ7-OX1-SB-334867 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant
30.77Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
30.77Consensuss1p_offOrthosteric Ligands1p1_off
30.56Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
30.56Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
30.30Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
30.30Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
30.30Single7XNACYN1548067XNA-SST2-CYN154806
30.30Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
30.30Consensusgi_chemerinOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
30.30Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
30.00Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
30.00Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
30.00Single6IBLArformoterol6IBL-β1-Arformoterol
30.00Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
30.00Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
30.00Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
30.00Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
30.00Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/&β;1/&γ;2
30.00Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
30.00Single7XJISolabegron7XJI-β3-Solabegron-Gs/&β;1/&γ;2
30.00Single7XZ6APD6687XZ6-GPR119-APD668-Gs/&β;1/&γ;2
30.00Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
30.00Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
30.00Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/&β;1/&γ;2
30.00Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
30.00Single8WRZ8D08WRZ-CB1-8D0-Arrestin1
30.00Consensusbileacid_onOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
30.00Consensusendothelin_offOrthosteric Ligandetb_off
30.00Consensusetb_offOrthosteric Ligand5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500 5X93-ETB-K-8794
30.00Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
30.00Consensussteroid_onOrthosteric Ligandbileacid_on
29.73Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
29.73Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
29.63Single3EMLZM2413853EML-A2A-ZM241385
29.63Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
29.63Single4YAYZD-71554YAY-AT1-ZD-7155
29.63Single5K2AZM2413855K2A-A2A-ZM241385-Na
29.63Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
29.63Single5UIGJ3.651.884G5UIG-A2A-J3.651.884G
29.63Single5VRAZM2413855VRA-A2A-ZM241385-Na
29.63Single6LPJZM2413856LPJ-A2A-ZM241385-Na
29.63Single6LPKZM2413856LPK-A2A-ZM241385-Na
29.63Single6PS1Timolol6PS1-β2-Timolol
29.63Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
29.63Single6S0LZM2413856S0L-A2A-ZM241385
29.63Single6TOTLemborexant6TOT-OX1-Lemborexant
29.63Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
29.63Single7CRHSKF839597CRH-D1-SKF83959-Gs/&β;1/&γ;2
29.63Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
29.63Single7UL4Alvimopan7UL4-μ-Alvimopan
29.63Single7V3ZPubMed 1048957V3Z-CB1-PubMed 104895
29.63Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/&β;1/&γ;2
29.63Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
29.63Single8CU6LJ-45178CU6-A2A-LJ-4517
29.63Single8EFQDamgo8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
29.63Single8GEHEpinephrine8GEH-β2-Epinephrine-Gs/&β;1/&γ;2
29.63Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/&β;1/&γ;2
29.63Consensusadenosine_onOrthosteric Liganda1_on a2_on
29.63Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
29.63Consensuscb1_on_alloOrthosteric Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
29.63Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
29.63Consensushca3_onOrthosteric Ligand8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
29.63Consensusnucleotide_onOrthosteric Ligandadenosine_on
29.41Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
29.41Single8J6IMK68928J6I-HCA2-MK6892-Gi1/&β;1/&γ;2
29.27Consensuspth_onOrthosteric Ligandpth1_on pth2_on
29.17Single3OE6IT1t3OE6-CXCR4-IT1t
29.17Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
29.17Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
29.03Single3NY9PubChem 9131033NY9-β2-PubChem 913103
29.03Single6KNMJN241-96KNM-Apelin-JN241-9
29.03Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
29.03Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
28.57Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
28.57Single5IUAQ274563485IUA-A2A-Q27456348-Na
28.57Single5NM2ZM2413855NM2-A2A-ZM241385-Na
28.57Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
28.57Single5WQCEMPA5WQC-OX2-EMPA
28.57Single6LPLZM2413856LPL-A2A-ZM241385-Na
28.57Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
28.57Single6S0QZM2413856S0Q-A2A-ZM241385
28.57Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
28.57Single6TP6Filorexant6TP6-OX1-Filorexant
28.57Single6WQAZM2413856WQA-A2A-ZM241385-Na
28.57Single7C4SS1P7C4S-S1P3-S1P
28.57Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
28.57Single7RM5ZM2413857RM5-A2A-ZM241385-Na
28.57Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
28.57Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
28.57Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
28.57Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
28.57Single7XKAEpinephrine7XKA-β2-Epinephrine
28.57Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
28.57Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
28.57Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
28.57Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
28.57Single8FYNZM2413858FYN-A2A-ZM241385-Na
28.57Single8ID9Eicosapentaenoic acid8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
28.57Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
28.57Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
28.57Single8QOTNanobody E8QOT-μ-Nanobody E
28.57Single8UNYEpinephrine8UNY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
28.57Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
28.57Consensusadrenergic_offOrthosteric Ligandbeta_off alpha_off
28.57Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
28.21Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
28.21Consensusglp_onOrthosteric Ligandglp1_on glp2_on
28.12Single4AMJ(S)-Carvedilol4AMJ-β1-(S)-Carvedilol
28.12Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
28.12Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
28.12Single8J6RMK68928J6R-HCA2-MK6892-Gi1/&β;1/&γ;2
28.12Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
28.00Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/&β;1/&γ;2
28.00Single8GH1Epinephrine8GH1-β2-Epinephrine
28.00Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2
28.00Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
28.00Single8K5BNiacin8K5B-HCA2-Niacin
28.00Consensusm4_on_alloOther Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
27.91Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
27.91Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
27.78Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
27.78Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
27.78Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
27.78Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
27.78Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
27.59Single2YDVNECA2YDV-A2A-NECA
27.59Single3P0GBI1671073P0G-β2-BI167107
27.59Single4UHRCGS216804UHR-A2A-CGS21680
27.59Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
27.59Single5G53NECA5G53-A2A-NECA-Gs
27.59Single5XR8AM8415XR8-CB1-AM841
27.59Single5XRAAM115425XRA-CB1-AM11542
27.59Single6H7JIsoprenaline6H7J-β1-Isoprenaline
27.59Single6J20Aprepitant6J20-NK1-Aprepitant
27.59Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
27.59Single6WGTLSD6WGT-5-HT2A-LSD
27.59Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2
27.59Single7FEEPubMed 1048957FEE-CB1-PubMed 104895-ZCZ011
27.59Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2
27.59Single7PX4PSB-21137PX4-A2A-PSB-2113
27.59Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
27.59Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
27.59Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
27.59Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
27.59Single7W41PD1762527W41-BB2-PD176252
27.59Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
27.59Single7XTQR3997XTQ-GPBA-R399-Gs/&β;1/&γ;2
27.59Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
27.59Single8EFLSR170188EFL-μ-SR17018-Gi1/&β;1/&γ;2
27.59Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2
27.59Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
27.59Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
27.59Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
27.59Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
27.59Consensus5ht5_offOrthosteric Ligand5ht5a_off
27.59Consensusa2_onOrthosteric Liganda2a_on a2b_on
27.59Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
27.59Consensusadenosine_offOrthosteric Liganda1_off a2_off
27.59Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
27.59Consensusbombesin_offOrthosteric Ligandbb2_off
27.59Consensuschemerin_onOrthosteric Ligandcml1_on
27.59Consensuscml1_onOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
27.59Consensuscyslt1_off_ortoalloOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
27.59Consensusdopamine_offOrthosteric Ligandd3_off d2_off d4_off
27.59Consensusgi_ffaOrthosteric Ligand8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
27.59Consensusgi_muscarinicOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
27.59Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A-NECA-Gs/&β;1/&γ;1 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
27.59Consensusgs_ffaOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2 8GDB-EP4-PGE2-Gs/&β;1/&γ;2
27.59Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
27.59Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
27.59Consensuslpa_offOrthosteric Ligandlpa1_off
27.59Consensuslpa_onOrthosteric Ligandlpa1_on
27.59Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
27.59Consensusnpy_offOrthosteric Ligandnpy2_off npy1_off
27.59Consensusrelaxin_onOrthosteric Ligandrxfp4_on
27.59Consensussst4_onOrthosteric Ligand7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
27.27Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
27.27Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
27.27Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
27.27Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
27.27Consensussst_offOrthosteric Ligandsst2_off
27.27Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
27.03Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
27.03Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
26.92Single2X72All-trans-retinal2X72-Rhodopsin-All-trans-retinal-Gt(CT)
26.92Single3ODUIT1t3ODU-CXCR4-IT1t
26.92Single3PWHZM2413853PWH-A2A-ZM241385
26.92Single3VGAZM2413853VGA-A2A-ZM241385-Antibody
26.92Single4BWBNeurotensin4BWB-NTS1-Neurotensin
26.92Single4S0VSuvorexant4S0V-OX2-Suvorexant
26.92Single5K2DZM2413855K2D-A2A-ZM241385
26.92Single5WS3EMPA5WS3-OX2-EMPA
26.92Single6AKXA4R6AKX-CCR5-A4R
26.92Single6JZHZM2413856JZH-A2A-ZM241385-Na
26.92Single6PS7ZM2413856PS7-A2A-ZM241385-Na
26.92Single6TODEMPA6TOD-OX1-EMPA-Na
26.92Single6TPJSuvorexant6TPJ-OX2-Suvorexant
26.92Single7BR3Elagolix7BR3-GnRH1-Elagolix
26.92Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
26.92Single7W0OElabela7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
26.92Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
26.92Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
26.92Single8EFOPZM218EFO-μ-PZM21-Gi1/&β;1/&γ;2
26.92Single8FN0Neurotensin/neuromedin N8FN0-NTS1-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
26.92Single8GGFEpinephrine8GGF-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
26.92Single8IHKAcifran8IHK-HCA3-Acifran
26.92Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2
26.92Single8IW4Spermidine8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
26.92Single8IWESpermidine8IWE-TAAR9-Spermidine
26.92Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/&β;1/&γ;2
26.92Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
26.92Single8UO0Epinephrine8UO0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
26.92Single8UO3Epinephrine8UO3-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
26.92Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
26.92Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
26.92Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
26.83Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
26.83Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
26.67Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
26.67Single4AMIBucindolol4AMI-β1-Bucindolol
26.67Single4LDEBI1671074LDE-β2-BI167107
26.67Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
26.67Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
26.67Single6A93Risperidone6A93-5-HT2A-Risperidone
26.67Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
26.67Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
26.67Single6KQIPubMed 1048956KQI-CB1-PubMed 104895-ORG27569
26.67Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
26.67Single6ZG4HTL00099366ZG4-M1-HTL0009936
26.67Single7DFPSpiperone7DFP-D2-Spiperone
26.67Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
26.67Single7K15MKD0467K15-BLT1-MKD046-Na
26.67Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
26.67Single7XMTJ-21567XMT-SST4-J-2156-Gi1/&β;1/&γ;2
26.67Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
26.67Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
26.67Single8JJ8Formoterol8JJ8-β2-Formoterol
26.67Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/&β;1/&γ;2
26.67Consensusat2_offOrthosteric Ligand7JNI-AT2-Olodanrigan
26.67Consensusblt1_offOrthosteric Ligand7K15-BLT1-MKD046-Na
26.67Consensusblt_offOrthosteric Ligandblt1_off
26.67Consensuscb1_off_alloOrthosteric Ligand6KQI-CB1-PubMed 104895-ORG27569
26.67Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
26.67Consensusleuko_offOrthosteric Ligandblt_off cyslt_off
26.67Consensusnts1_onOrthosteric Ligand6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
26.67Consensusnts_onOrthosteric Ligandnts1_on
26.67Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
26.47Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
26.47Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
26.47Consensusmc5_onOrthosteric Ligand8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
26.32Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
26.32Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
26.19Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
25.93Single2YDOAdenosine2YDO-A2A-Adenosine
25.93Single3REYPubChem 56973REY-A2A-PubChem 5697
25.93Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
25.93Single4MBSMaraviroc4MBS-CCR5-Maraviroc
25.93Single5IU4ZM2413855IU4-A2A-ZM241385-Na
25.93Single5IU7Q274563465IU7-A2A-Q27456346-Na
25.93Single5IUBQ274563445IUB-A2A-Q27456344-Na
25.93Single5JTBZM2413855JTB-A2A-ZM241385
25.93Single5K2CZM2413855K2C-A2A-ZM241385-Na
25.93Single5NM4ZM2413855NM4-A2A-ZM241385-Na
25.93Single5UVIZM2413855UVI-A2A-ZM241385
25.93Single6IQLL7458706IQL-D4-L745870
25.93Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
25.93Single6PS4ICI 118-5516PS4-β2-ICI 118-551
25.93Single6PS5(S)-Propranolol6PS5-β2-(S)-Propranolol
25.93Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
25.93Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
25.93Single6TP3Nemorexant6TP3-OX1-Nemorexant
25.93Single6TPGEMPA6TPG-OX2-EMPA
25.93Single6TPNHTL66416TPN-OX2-HTL6641
25.93Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
25.93Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
25.93Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
25.93Single6ZDVPubChem 9840736ZDV-A2A-PubChem 984073-Na
25.93Single7BB6Acyclovir triphosphate7BB6-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
25.93Single7JOZVFP7JOZ-D1-VFP-Gs/&β;1/&γ;2
25.93Single7T32ZM2413857T32-A2A-ZM241385
25.93Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
25.93Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
25.93Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
25.93Single8GDZEpinephrine8GDZ-β2-Epinephrine-Gs/&β;1/&γ;2
25.93Single8GEGEpinephrine8GEG-β2-Epinephrine-Gs/&β;1/&γ;2
25.93Single8GGKEpinephrine8GGK-β2-Epinephrine
25.93Single8GGMEpinephrine8GGM-β2-Epinephrine
25.93Single8GGPEpinephrine8GGP-β2-Epinephrine
25.93Single8GGQEpinephrine8GGQ-β2-Epinephrine
25.93Single8GGTEpinephrine8GGT-β2-Epinephrine
25.93Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2
25.93Single8JHNMMF8JHN-HCA2-MMF-Go/&β;1/&γ;2
25.93Single8UNZEpinephrine8UNZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.93Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/&β;1/&γ;2
25.93Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
25.93Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
25.93Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
25.93Consensusm1_off_alloOther Ligand6WJC-M1-Atropine-Muscarinic toxin 7
25.93Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
25.81Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
25.81Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
25.81Single6H7LDobutamine6H7L-β1-Dobutamine
25.81Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
25.81Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
25.81Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
25.81Single7UM4AS26747237UM4-5-HT5A-AS2674723
25.81Single7XK2MK68927XK2-HCA2-MK6892-Gi1/&β;1/&γ;2
25.81Single8GAGYVF8GAG-CB1-YVF-Gi1/&β;1/&γ;2
25.81Single8ID8TUG-8918ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
25.81Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.81Consensus5ht5a_offOrthosteric Ligand7UM4-5-HT5A-AS2674723
25.81Consensusbeta1_off_alloOrthosteric Ligand4BVN-β1-Cyanopindolol-Na
25.81Consensusffa4_on_alloOrthosteric Ligand8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.81Consensusot_onOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
25.71Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
25.71Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
25.71Single8IHFMK68928IHF-HCA2-MK6892-Gi1/&β;1/&γ;2
25.71Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
25.00Single2Y02Carmoterol2Y02-β1-Carmoterol
25.00Single2Y04Salbutamol2Y04-β1-Salbutamol
25.00Single3NY8ICI 118-5513NY8-β2-ICI 118-551
25.00Single3NYA(S)-Alprenolol3NYA-β2-(S)-Alprenolol
25.00Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
25.00Single4EIYZM2413854EIY-A2A-ZM241385-Na
25.00Single4EJ4Naltrindole4EJ4-δ-Naltrindole
25.00Single4GBR(S)-Carazolol4GBR-β2-(S)-Carazolol
25.00Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
25.00Single4QKXPubChem 762106284QKX-β2-PubChem 76210628
25.00Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
25.00Single5DHGPubChem 250014125DHG-NOP-PubChem 25001412
25.00Single5IU8Q274563475IU8-A2A-Q27456347-Na
25.00Single5JQH(S)-Carazolol5JQH-β2-(S)-Carazolol
25.00Single5OLGZM2413855OLG-A2A-ZM241385-Na
25.00Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
25.00Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
25.00Single5T04Neurotensin5T04-NTS1-Neurotensin
25.00Single5UENDU1725UEN-A1-DU172
25.00Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
25.00Single6DRXLisuride6DRX-5-HT2B-Lisuride
25.00Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
25.00Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
25.00Single6PS0(S)-Carazolol6PS0-β2-(S)-Carazolol
25.00Single6PS2(S)-Alprenolol6PS2-β2-(S)-Alprenolol
25.00Single6PT3DPI-2876PT3-δ-DPI-287
25.00Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
25.00Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
25.00Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
25.00Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
25.00Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
25.00Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
25.00Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
25.00Single7LJCPubChem 867641037LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
25.00Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
25.00Single7PYRPSB-21157PYR-A2A-PSB-2115
25.00Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
25.00Single7SCGFH2107SCG-μ-FH210-Gi1/&β;1/&γ;2
25.00Single7T2GMitragynine pseudoindoxyl7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
25.00Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
25.00Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
25.00Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
25.00Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
25.00Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
25.00Single8A2OTheophylline8A2O-A2A-Theophylline-Na
25.00Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
25.00Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
25.00Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
25.00Single8GE3Epinephrine8GE3-β2-Epinephrine-Gs/&β;1/&γ;2
25.00Single8GEBEpinephrine8GEB-β2-Epinephrine-Gs/&β;1/&γ;2
25.00Single8GEEEpinephrine8GEE-β2-Epinephrine-Gs/&β;1/&γ;2
25.00Single8GFWEpinephrine8GFW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.00Single8GFXEpinephrine8GFX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.00Single8GFYEpinephrine8GFY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.00Single8GFZEpinephrine8GFZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.00Single8GG0Epinephrine8GG0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.00Single8GG1Epinephrine8GG1-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.00Single8GG2Epinephrine8GG2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.00Single8GG6Epinephrine8GG6-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.00Single8GGBEpinephrine8GGB-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.00Single8GGJEpinephrine8GGJ-β2-Epinephrine
25.00Single8GGNEpinephrine8GGN-β2-Epinephrine
25.00Single8GGOEpinephrine8GGO-β2-Epinephrine
25.00Single8GGUEpinephrine8GGU-β2-Epinephrine
25.00Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
25.00Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
25.00Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2
25.00Single8IYHMK68928IYH-HCA2-MK6892-Go/&β;1/&γ;2
25.00Single8JJOAlprenolol8JJO-β2-Alprenolol
25.00Single8UNMEpinephrine8UNM-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.00Single8UNNEpinephrine8UNN-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.00Single8UNPEpinephrine8UNP-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.00Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
25.00Single8X5YAstemizole8X5Y-H1-Astemizole
25.00Single8XZFWN5618XZF-Apelin-WN561-Gi1/&β;1/&γ;2
25.00Consensus5ht1a_onOrthosteric Ligand8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
25.00Consensusa2_offOrthosteric Liganda2a_off
25.00Consensusa2a_offOrthosteric Ligand8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 5UIG-A2A-J3.651.884G 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-PubChem 168451710 5K2D-A2A-ZM241385
25.00Consensusadrenergic_onOrthosteric Ligandbeta_on alpha_on
25.00Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
25.00Consensusdopamine_onOrthosteric Ligandd3_on d2_on d5_on d1_on
25.00Consensusffa_onOrthosteric Ligandffa4_on ffa1_on ffa2_on ffa3_on
25.00Consensusgo_vasopressinOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
25.00Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
24.39Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
24.39Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
24.32Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
24.24Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
24.24Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
24.24Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
24.14Single2RH1(S)-Carazolol2RH1-β2-(S)-Carazolol
24.14Single2Y03Isoprenaline2Y03-β1-Isoprenaline
24.14Single2YCW(S)-Carazolol2YCW-β1-(S)-Carazolol
24.14Single5D6L(S)-Carazolol5D6L-β2-(S)-Carazolol
24.14Single5TVNLSD5TVN-5-HT2B-LSD
24.14Single5WIUNemonapride5WIU-D4-Nemonapride
24.14Single5WIVNemonapride5WIV-D4-Nemonapride-Na
24.14Single5X7D(S)-Carazolol5X7D-β2-(S)-Carazolol-PubChem 129318963
24.14Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
24.14Single6E67BI1671076E67-β2-BI167107-Gs (fused)
24.14Single6GDGNECA6GDG-A2A-NECA-Gs/&β;1/&γ;1
24.14Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
24.14Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
24.14Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
24.14Single6PS3(S)-Carvedilol6PS3-β2-(S)-Carvedilol
24.14Single6PS6Timolol6PS6-β2-Timolol
24.14Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
24.14Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
24.14Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
24.14Single7BVQ(S)-Carazolol7BVQ-β1-(S)-Carazolol
24.14Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
24.14Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2
24.14Single7SBFPZM217SBF-μ-PZM21-Gi1/&β;1/&γ;2
24.14Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
24.14Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
24.14Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
24.14Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
24.14Single8J19PubChem 1270454228J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
24.14Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
24.14Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
24.14Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
24.14Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide 6DRX-5-HT2B-Lisuride
24.14Consensusa2a_onOrthosteric Ligand6GDG-A2A-NECA-Gs/&β;1/&γ;1
24.14Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
24.14Consensusamine_offOrthosteric Ligandadrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
24.14Consensusbeta2_offOrthosteric Ligand6PS2-β2-(S)-Alprenolol 6PS3-β2-(S)-Carvedilol 6PS5-β2-(S)-Propranolol 6PS6-β2-Timolol 2RH1-β2-(S)-Carazolol 6PS4-β2-ICI 118-551 3NY9-β2-PubChem 913103
24.14Consensusbeta2_onOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
24.14Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
24.14Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
24.14Consensusd4_offOrthosteric Ligand5WIU-D4-Nemonapride
24.14Consensusd4_off_alloOrthosteric Ligand5WIV-D4-Nemonapride-Na
24.14Consensusgi_adrenergicOrthosteric Ligand7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
24.14Consensusgs_adrenergicOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJI-β3-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
24.14Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
24.14Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
24.00Single3OE8IT1t3OE8-CXCR4-IT1t
24.00Single4XNWMRS25004XNW-P2Y1-MRS2500
24.00Single6ME5Agomelatine6ME5-MT1-Agomelatine
24.00Single8GGREpinephrine8GGR-β2-Epinephrine
24.00Single8J6QBeta-hydroxybutyrate8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
24.00Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
23.68Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
23.68Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
23.53Single6HLOAprepitant6HLO-NK1-Aprepitant
23.53Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
23.53Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
23.40Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
23.33Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
23.33Single4DJHJDTic4DJH-κ-JDTic
23.33Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
23.33Single5D5A(S)-Carazolol5D5A-β2-(S)-Carazolol
23.33Single5D5B(S)-Carazolol5D5B-β2-(S)-Carazolol
23.33Single5TZR-5TZR-FFA1 (GPR40)-MK8666
23.33Single5X93K-87945X93-ETB-K-8794
23.33Single6E59L-7607356E59-NK1-L-760735
23.33Single6J21Aprepitant6J21-NK1-Aprepitant
23.33Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
23.33Single7W6PW967W6P-α2a-W96-Go/&β;1/&γ;2
23.33Single7W7EW587W7E-α2a-W58-Go/&β;1/&γ;2
23.33Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
23.33Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/&β;1/&γ;2
23.33Single8G056-OAU8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
23.33Single8GUSHU-3088GUS-CB2-HU-308-Gi1/&β;1/&γ;2
23.33Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/&β;1/&γ;2
23.33Single8JXVClozapine8JXV-H4-Clozapine-Gi1/&β;1/&γ;2
23.33Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
23.33Consensus5ht_offOrthosteric Ligand5ht2_off 5ht5_off 5ht1_off
23.33Consensusangiotensin_offOrthosteric Ligandat1_off at2_off
23.33Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCZ-β1-Iodocyanopindolol
23.33Consensusgi_amineOrthosteric Ligandgi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
23.33Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
23.33Consensusnk1_offOrthosteric Ligand6J20-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
23.08Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
23.08Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
23.08Single6HLLCP999946HLL-NK1-CP99994
23.08Single6LMLGlucagon6LML-Glucagon-Glucagon
23.08Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
23.08Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
23.08Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
23.08Single7SRQLSD7SRQ-5-HT2B-LSD
23.08Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
23.08Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
23.08Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2
23.08Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
23.08Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
23.08Single8EF6Morphine8EF6-μ-Morphine-Gi1/&β;1/&γ;2
23.08Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
23.08Single8GEIEpinephrine8GEI-β2-Epinephrine-Gs/&β;1/&γ;2
23.08Single8GGCEpinephrine8GGC-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
23.08Single8GGEEpinephrine8GGE-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
23.08Single8GGSEpinephrine8GGS-β2-Epinephrine
23.08Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2
23.08Single8IJANiacin8IJA-HCA2-Niacin-Gi1/&β;1/&γ;2
23.08Single8IY9Niacin8IY9-HCA2-Niacin-Go/&β;1/&γ;2
23.08Single8JILNiacin8JIL-HCA2-Niacin-Gi1/&β;1/&γ;2
23.08Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
23.08Single8UNVEpinephrine8UNV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
23.08Consensus5ht4_onOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
23.08Consensusox1_off_alloOrthosteric Ligand6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na 6TO7-OX1-Suvorexant-Na
23.08Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
22.58Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
22.58Single3D4STimolol Maleate3D4S-β2-Timolol Maleate
22.58Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
22.58Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
22.58Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
22.58Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
22.58Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
22.58Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
22.58Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
22.58Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
22.58Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
22.58Single8IJDMK68928IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
22.58Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
22.58Consensusbeta1_onOrthosteric Ligand7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
22.58Consensusnts1_offOrthosteric Ligand6Z4Q-NTS1-SR142948A 6Z4S-NTS1-SR48692
22.58Consensusnts_offOrthosteric Ligandnts1_off
22.50Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
22.22Single3VG9ZM2413853VG9-A2A-ZM241385-Antibody
22.22Single5DHHSB-6121115DHH-NOP-SB-612111
22.22Single5ZKQABT-4915ZKQ-PAF-ABT-491
22.22Single6AKYMaraviroc6AKY-CCR5-Maraviroc
22.22Single6B73PubChem 1319551386B73-κ-PubChem 131955138
22.22Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/&β;1/&γ;2
22.22Single6ME2Ramelteon6ME2-MT1-Ramelteon
22.22Single6NWEOctyl Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
22.22Single6OBA(S)-Alprenolol6OBA-β2-(S)-Alprenolol-GTPL11074
22.22Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
22.22Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
22.22Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
22.22Single6WWZCCL206WWZ-CCR6-CCL20-Go/&β;1/&γ;2
22.22Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
22.22Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2
22.22Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
22.22Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
22.22Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.22Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
22.22Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2
22.22Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
22.22Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
22.22Single8GECEpinephrine8GEC-β2-Epinephrine-Gs/&β;1/&γ;2
22.22Single8GEDEpinephrine8GED-β2-Epinephrine-Gs/&β;1/&γ;2
22.22Single8GEFEpinephrine8GEF-β2-Epinephrine-Gs/&β;1/&γ;2
22.22Single8GG7Epinephrine8GG7-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.22Single8GG9Epinephrine8GG9-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.22Single8GGAEpinephrine8GGA-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.22Single8GGVEpinephrine8GGV-β2-Epinephrine
22.22Single8GGWEpinephrine8GGW-β2-Epinephrine
22.22Single8GGXEpinephrine8GGX-β2-Epinephrine
22.22Single8GH0Epinephrine8GH0-β2-Epinephrine
22.22Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
22.22Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/&β;1/&γ;2
22.22Single8UNLEpinephrine8UNL-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.22Single8UNOEpinephrine8UNO-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.22Single8UNTEpinephrine8UNT-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.22Single8UNUEpinephrine8UNU-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.22Single8UNWEpinephrine8UNW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.22Single8UO1Epinephrine8UO1-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
22.22Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
22.22Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
22.22Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
22.22Consensusa2a_off_alloOrthosteric Ligand6ZDR-A2A-HMS1413f12-Na 6GT3-A2A-Imaradenant-Na 8CU7-A2A-LJ-4517-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PubChem 92460631; psb36-Na 5MZJ-A2A-Theophylline-Na 5OLO-A2A-Tozadenant-Na 5OLH-A2A-Vipadenant-Na 5NM4-A2A-ZM241385-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5MZP-A2A-Caffeine-Na 8CIC-A2A-Etrumadenant-Na
22.22Consensusalpha2_offOrthosteric Ligandalpha2a_off alpha2c_off
22.22Consensusbeta2_off_alloOrthosteric Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
22.22Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
22.22Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
22.22Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
21.95Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
21.88Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
21.88Single6K1QIRL25006K1Q-ETB-IRL2500
21.88Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
21.88Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
21.88Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
21.88Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
21.88Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
21.62Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
21.62Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
21.62Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
21.43Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
21.43Single4DKLBeta-funaltrexamine4DKL-μ-Beta-funaltrexamine
21.43Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
21.43Single5TE3Octyl Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
21.43Single6AQFZM2413856AQF-A2A-ZM241385
21.43Single6DS0Ly2660976DS0-5-HT2B-Ly266097
21.43Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
21.43Single6TPKRetosiban6TPK-OT-Retosiban
21.43Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
21.43Single6ZG9GSK10347026ZG9-M1-GSK1034702
21.43Single6ZINSR486926ZIN-NTS1-SR48692
21.43Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
21.43Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/&β;1/&γ;2
21.43Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
21.43Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
21.43Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
21.43Single7F0TDopamine7F0T-D1-Dopamine-Gs/&β;1/&γ;2
21.43Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/&β;1/&γ;2
21.43Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.43Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
21.43Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
21.43Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
21.43Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.43Single8GE1Epinephrine8GE1-β2-Epinephrine-Gs/&β;1/&γ;2
21.43Single8GE4Epinephrine8GE4-β2-Epinephrine-Gs/&β;1/&γ;2
21.43Single8GE6Epinephrine8GE6-β2-Epinephrine-Gs/&β;1/&γ;2
21.43Single8GE7Epinephrine8GE7-β2-Epinephrine-Gs/&β;1/&γ;2
21.43Single8GE8Epinephrine8GE8-β2-Epinephrine-Gs/&β;1/&γ;2
21.43Single8GE9Epinephrine8GE9-β2-Epinephrine-Gs/&β;1/&γ;2
21.43Single8GFVEpinephrine8GFV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.43Single8GG3Epinephrine8GG3-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.43Single8GG4Epinephrine8GG4-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.43Single8GG5Epinephrine8GG5-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.43Single8GG8Epinephrine8GG8-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.43Single8GGIEpinephrine8GGI-β2-Epinephrine
21.43Single8GGLEpinephrine8GGL-β2-Epinephrine
21.43Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
21.43Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
21.43Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
21.43Single8JLNT1AM8JLN-TA1-T1AM-Gs/&β;1/&γ;2
21.43Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.43Single8UHBRO52563908UHB-TA1-RO5256390-Gs/&β;1/&γ;2
21.43Single8UNQEpinephrine8UNQ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.43Single8UNREpinephrine8UNR-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.43Single8UNSEpinephrine8UNS-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.43Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6WH4-5-HT2A-Methiothepin 7VOE-5-HT2A-Aripiprazole 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 6A93-5-HT2A-Risperidone
21.43Consensus5ht5_onOrthosteric Ligand5ht5a_on
21.43Consensus5ht5a_onOrthosteric Ligand7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
21.43Consensusalpha2b_onOrthosteric Ligand6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
21.43Consensusd1_on_alloOrthosteric Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
21.43Consensusd3_onOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
21.43Consensusdop_off_alloOrthosteric Ligand4N6H-δ-Naltrindole-Na
21.43Consensusffa2_onOrthosteric Ligand8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
21.43Consensusgs_tarOrthosteric Ligand8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
21.43Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
21.43Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
21.43Consensusvasopressin-ot_offOrthosteric Ligandot_off
21.21Single5EE7MK08935EE7-Glucagon-MK0893
21.21Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.21Single7SK9CCX6627SK9-ACKR3-CCX662
21.21Single8INRAlpha-MSH8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
21.21Consensusclass-d_offOrthosteric Ligandste2_off
21.05Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
21.05Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/&β;1/&γ;2
21.05Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
21.05Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
21.05Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
21.05Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
20.93Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
20.83Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
20.83Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
20.83Single8GEJEpinephrine8GEJ-β2-Epinephrine-Gs/&β;1/&γ;2
20.83Single8PWNTheophylline8PWN-A2A-Theophylline
20.69Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
20.69Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
20.69Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
20.69Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
20.69Single4X1HNonyl Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
20.69Single5TGZAM65385TGZ-CB1-AM6538
20.69Single6H7MSalbutamol6H7M-β1-Salbutamol
20.69Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
20.69Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2
20.69Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/&β;1/&γ;2
20.69Single6PRZ(S)-Alprenolol6PRZ-β2-(S)-Alprenolol
20.69Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
20.69Single7BU7BI1671077BU7-β1-BI167107
20.69Single7CFMP3957CFM-GPBA-P395-Gs/&β;1/&γ;2
20.69Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
20.69Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
20.69Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
20.69Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
20.69Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
20.69Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
20.69Single7VKTLTB47VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
20.69Single7WC7Lisuride7WC7-5-HT2A-Lisuride
20.69Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
20.69Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
20.69Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
20.69Single8EJCTAK-8758EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
20.69Single8J18(3R)-3-hydroxydodecanoic acid8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
20.69Single8JLZST19368JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
20.69Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
20.69Single8UO4Epinephrine8UO4-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
20.69Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
20.69Single8X63Mepyramine8X63-H1-Mepyramine
20.69Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
20.69Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
20.69Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
20.69Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
20.69Consensusalpha2_onOrthosteric Ligandalpha2a_on alpha2b_on
20.69Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
20.69Consensusamine_onOrthosteric Ligandadrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
20.69Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
20.69Consensusblt_onOrthosteric Ligandblt1_on
20.69Consensusgi_5htOrthosteric Ligand7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
20.69Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
20.69Consensushcar_offOrthosteric Ligandsuccinate_off
20.69Consensusleuko_onOrthosteric Ligandblt_on
20.69Consensusprostanoid_offOrthosteric Ligandep_off tp_off dp_off
20.69Consensussmo_offOrthosteric Ligand5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
20.69Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
20.69Consensustachykinin_offOrthosteric Ligandnk1_off
20.69Consensustar_onOrthosteric Ligandta1_on
20.59Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
20.59Single7QA8Peptide7QA8-STE2-Peptide
20.59Single7QA8Peptide7QA8-STE2-Peptide
20.59Consensusclass-d_offOrthosteric Ligandste2_off
20.51Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
20.51Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
20.51Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
20.51Consensusgo_class-b1Orthosteric Ligandgo_crf
20.51Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
20.51Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
20.45Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
20.00Single2Y00Dobutamine2Y00-β1-Dobutamine
20.00Single3RFMCaffeine3RFM-A2A-Caffeine
20.00Single4PHUFasiglifam4PHU-FFA1 (GPR40)-Fasiglifam
20.00Single5XPRBosentan5XPR-ETB-Bosentan
20.00Single5ZK3Quinuclidinyl benzilate hydrobromide5ZK3-M2-Quinuclidinyl benzilate hydrobromide
20.00Single6LUQHaloperidol6LUQ-D2-Haloperidol
20.00Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
20.00Single6TQ9SB-4081246TQ9-OX1-SB-408124
20.00Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
20.00Single6Z4SSR486926Z4S-NTS1-SR48692
20.00Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
20.00Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
20.00Single7SINNPS-21437SIN-CaS-NPS-2143
20.00Single7SINNPS-21437SIN-CaS-NPS-2143
20.00Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
20.00Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
20.00Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
20.00Single7WC6LSD7WC6-5-HT2A-LSD
20.00Single7YXAONO-54306087YXA-S1P5-ONO-5430608
20.00Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
20.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
20.00Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
20.00Consensusalpha2a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
20.00Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
20.00Consensuscrf1_onOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
20.00Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
20.00Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
20.00Consensusgo_amineOrthosteric Ligandgo_adrenergic go_muscarinic go_5ht
20.00Consensushca2_on_alloOrthosteric Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
20.00Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
19.51Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
19.51Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
19.51Consensusgs_crfOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
19.35Single3UONQuinuclidinyl benzilate hydrobromide3UON-M2-Quinuclidinyl benzilate hydrobromide
19.35Single5V56TC1145V56-SMO-TC114
19.35Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
19.35Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
19.35Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
19.35Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
19.35Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
19.35Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2
19.35Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
19.35Single8JD0J9R8JD0-mGlu2; mGlu3-Glutamate-J9R
19.35Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
19.35Single8JXWVUF68848JXW-H4-VUF6884-Gi1/&β;1/&γ;2
19.35Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
19.35Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
19.35Consensusgo_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
19.35Consensush1_offOrthosteric Ligand3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole 8X63-H1-Mepyramine 8X64-H1-Desloratadine
19.35Consensushistamine_offOrthosteric Ligandh1_off
19.23Single5WKTOctyl Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
19.23Single6ME9Ramelteon6ME9-MT2-Ramelteon
19.23Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/&β;1/&γ;2
19.23Single7WC5Psilocin7WC5-5-HT2A-Psilocin
19.23Single8GGZEpinephrine8GGZ-β2-Epinephrine
19.23Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
19.23Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
19.23Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.75Single4N4WSANT-14N4W-SMO-SANT-1
18.75Single6CM4Risperidone6CM4-D2-Risperidone
18.75Single6H7N(S)-Xamoterol6H7N-β1-(S)-Xamoterol
18.75Single6HLPNetupitant6HLP-NK1-Netupitant
18.75Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
18.75Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.75Single8GCPPGE28GCP-EP4-PGE2-Gi1/&β;1/&γ;2
18.75Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
18.75Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg3_on
18.75Consensusclass-b2_onOrthosteric Ligandadgrg_on
18.75Consensusgi_class-fOther Ligandgi_frizzled
18.75Consensusgi_frizzledOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
18.75Consensusgi_prostanoidOrthosteric Ligand8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GDC-EP3-PGE2-Gi1/&β;1/&γ;2 8GCM-EP4-L902688-Gi1/&β;1/&γ;2
18.60Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
18.52Single3PBLEticlopride3PBL-D3-Eticlopride
18.52Single6TP4ACT-4622066TP4-OX1-ACT-462206
18.52Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2
18.52Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
18.52Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2
18.52Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.52Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.52Single8GGYEpinephrine8GGY-β2-Epinephrine
18.52Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
18.52Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
18.52Single8UNXEpinephrine8UNX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
18.52Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
18.52Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
18.52Consensusclass-t_onOrthosteric Ligandtaste2_on
18.52Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
18.52Consensusgo_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
18.52Consensusgo_proteinOrthosteric Ligandgo_chemokine
18.52Consensusgs_class-tOrthosteric Ligandgs_taste
18.52Consensusgs_tasteOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
18.52Consensusmt2_onOrthosteric Ligand7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
18.52Consensustaste2_onOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
18.42Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
18.42Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
18.42Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
18.42Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
18.18Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
18.18Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
18.18Single8E9YPubChem 4466038E9Y-M3-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.18Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.18Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.18Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
18.18Consensusep4_onOrthosteric Ligand7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2
18.18Consensusgs_lipidOrthosteric Ligandgs_ffa gs_prostanoid
17.95Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
17.95Single7D3SSecretin7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
17.95Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
17.95Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
17.95Consensusclass-d_onOrthosteric Ligandste2_on
17.95Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
17.86Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
17.86Single6KUXRS-799486KUX-α2a-RS-79948
17.86Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
17.86Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
17.86Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2
17.86Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/&β;1/&γ;2
17.86Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
17.86Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
17.86Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
17.86Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
17.86Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
17.86Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
17.86Single7TUZ7alpha,25-dihydroxycholesterol7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
17.86Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
17.86Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
17.86Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
17.86Single8GEAEpinephrine8GEA-β2-Epinephrine-Gs/&β;1/&γ;2
17.86Single8HOCImetit8HOC-H4-Imetit-Gi1/&β;1/&γ;2
17.86Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
17.86Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.86Consensus5ht2_onOrthosteric Ligand5ht2a_on 5ht2c_on
17.86Consensusalpha1_onOrthosteric Ligandalpha1a_on
17.86Consensusalpha1a_onOrthosteric Ligand7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.86Consensusalpha2a_offOrthosteric Ligand6KUX-α2a-RS-79948
17.86Consensusgi_histamineOrthosteric Ligand8HN8-H4-Histamine-Gi1/&β;1/&γ;2 8HOC-H4-Imetit-Gi1/&β;1/&γ;2
17.86Consensusgs_5htOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.86Consensusgs_histamineOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.86Consensush4_onOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.86Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
17.86Consensusmelatonin_onOrthosteric Ligandmt1_on mt2_on
17.86Consensusmglu_onOther Ligandmglu2_on mglu4_on
17.78Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
17.65Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
17.65Single8SAI1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
17.50Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
17.50Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
17.50Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
17.50Consensusgi_class-dOrthosteric Ligandgi_ste
17.50Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
17.50Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
17.24Single3RZECidoxepin3RZE-H1-Cidoxepin
17.24Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
17.24Single6A94Zotepine6A94-5-HT2A-Zotepine
17.24Single6VI4JDTic6VI4-κ-JDTic
17.24Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
17.24Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
17.24Single7CMVPD1289077CMV-D3-PD128907-Gi1/&β;1/&γ;2
17.24Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
17.24Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.24Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
17.24Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2
17.24Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
17.24Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.24Single8HQN9(S)-HODE8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
17.24Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2
17.24Single8K4NVF08K4N-GPR34-VF0-Gi1/&β;1/&γ;2
17.24Single8T3VDHA8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.24Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.24Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
17.24Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.24Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
17.24Consensus5ht2a_onOrthosteric Ligand7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.24Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
17.24Consensusgi_melatoninOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
17.24Consensusm1_off_alloOrthosteric Ligand6WJC-M1-Atropine-Muscarinic toxin 7
17.14Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
17.14Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
17.14Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
17.07Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
17.07Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
17.07Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
16.67Single2Y01Dobutamine2Y01-β1-Dobutamine
16.67Single4DAJTiotropium4DAJ-M3-Tiotropium
16.67Single4MQSIperoxo4MQS-M2-Iperoxo
16.67Single4U14Tiotropium4U14-M3-Tiotropium
16.67Single4U16N-Methyl Scopolamine4U16-M3-N-Methyl Scopolamine
16.67Single5MZPCaffeine5MZP-A2A-Caffeine-Na
16.67Single5YC8N-Methyl Scopolamine5YC8-M2-N-Methyl Scopolamine
16.67Single5ZK8N-Methyl Scopolamine5ZK8-M2-N-Methyl Scopolamine
16.67Single5ZKCN-Methyl Scopolamine5ZKC-M2-N-Methyl Scopolamine
16.67Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
16.67Single6GPSMK08126GPS-CCR2-MK0812
16.67Single6IIVDaltroban6IIV-TP-Daltroban
16.67Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
16.67Single7F83PF-051904577F83-Ghrelin-PF-05190457
16.67Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
16.67Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
16.67Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
16.67Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
16.67Single8EJKTAK-8758EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
16.67Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
16.67Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single8WCCCyclohexylammonium ion8WCC-TA1-Cyclohexylammonium ion
16.67Single8X64Desloratadine8X64-H1-Desloratadine
16.67Consensusffa1_onOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67Consensusgo_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
16.67Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
16.67Consensushistamine_onOrthosteric Ligandh1_on h4_on
16.67Consensusm2_on_alloOrthosteric Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
16.67Consensusm4_on_alloOrthosteric Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
16.67Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
16.67Consensusp2y12_offOrthosteric Ligand4NTJ-P2Y12-AZD1283 7PP1-P2Y12-Selatogrel
16.67Consensustp_offOrthosteric Ligand6IIV-TP-Daltroban 6IIU-TP-Ramatroban
16.22Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
16.13Single4JKVTaladegib (LY2940680)4JKV-SMO-Taladegib (LY2940680)
16.13Single4NTJAZD12834NTJ-P2Y12-AZD1283
16.13Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
16.13Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
16.13Single6GPXMK08126GPX-CCR2-MK0812
16.13Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
16.13Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
16.13Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2
16.13Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
16.13Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.13Single8EA0Iperoxo8EA0-M3-Iperoxo
16.13Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2
16.13Single8GDAL9026888GDA-EP4-L902688-Gs/&β;1/&γ;2
16.13Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
16.13Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
16.13Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
16.13Consensusep_offOrthosteric Ligandep4_off
16.13Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
16.13Consensusgs_muscarinicOrthosteric Ligand8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.13Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
16.13Consensusm2_offOrthosteric Ligand5ZKB-M2-AF-DX 384 5ZKC-M2-N-Methyl Scopolamine 5ZK3-M2-Quinuclidinyl benzilate hydrobromide
16.13Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.00Single7WC4Serotonin7WC4-5-HT2A-Serotonin
16.00Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/&β;1/&γ;2
15.79Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
15.79Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
15.79Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
15.62Single4U15Tiotropium4U15-M3-Tiotropium
15.62Single5V54Methiothepin5V54-5-HT1B-Methiothepin
15.62Single5V57TC1145V57-SMO-TC114
15.62Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
15.62Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
15.62Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
15.62Single6OL9Tiotropium6OL9-M5-Tiotropium
15.62Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
15.62Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
15.62Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
15.62Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/&β;1/&γ;2
15.62Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.62Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
15.62Consensus5ht1_offOrthosteric Ligand5ht1b_off
15.62Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
15.62Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl Scopolamine 5ZHP-M3-PubChem 134828589
15.62Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
15.62Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
15.62Consensuss1p2_onOrthosteric Ligand7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
15.56Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
15.38Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
15.38Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
15.38Single8IWM2-Phenylethylamine8IWM-TAAR9-2-Phenylethylamine
15.38Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/&β;1/&γ;2
15.38Single8WC5Tetramethylammonium ion8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2
15.15Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
15.15Single4PY02MeSATP4PY0-P2Y12-2MeSATP
15.15Single5CXVTiotropium5CXV-M1-Tiotropium
15.15Single5X33BIIL2605X33-BLT1-BIIL260
15.15Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
15.15Single6IIURamatroban6IIU-TP-Ramatroban
15.15Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
15.15Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/&β;1/&γ;2
15.15Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.15Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.15Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
15.15Consensusep_onOrthosteric Ligandep4_on ep2_on ep3_on
15.15Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
15.00Consensusghrh_onOrthosteric Ligand7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
14.81Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
14.81Single3UZAGTPL92363UZA-A2A-GTPL9236
14.81Single6FUFAll-trans-retinal6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2
14.81Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.81Single8EITDoconexent8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
14.81Single8IW72-Phenylethylamine8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
14.81Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
14.81Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
14.81Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/&β;1/&γ;2
14.81Single8POKHistamine8POK-H2-Histamine-Gs/&β;1/&γ;2
14.81Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
14.81Consensussmo_off_alloOrthosteric Ligand6D32-SMO-Cyclopamine-Cyclopamine
14.71Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
14.71Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
14.71Consensusfpa_onOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.71Consensusgs_prostanoidOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.63Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
14.63Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
14.29Single4O9RCyclopamine4O9R-SMO-Cyclopamine
14.29Single5L7IVismodegib5L7I-SMO-Vismodegib
14.29Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
14.29Single6QNOAll-trans-retinal6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
14.29Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
14.29Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
14.29Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
14.29Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
14.29Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
14.29Single7UL2SR486927UL2-NTS1-SR48692-Na
14.29Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
14.29Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
14.29Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Single8HN8Histamine8HN8-H4-Histamine-Gi1/&β;1/&γ;2
14.29Single8ITFDMCHA8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
14.29Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
14.29Consensusgo_adhesionOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
14.29Consensusgo_class-b2Orthosteric Ligandgo_adhesion
14.29Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
14.29Consensusgs_adgrOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Consensusgs_class-b2Orthosteric Ligandgs_adgr
14.29Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
14.29Consensusmt1_onOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
14.29Consensusnts1_off_alloOrthosteric Ligand7UL2-NTS1-SR48692-Na
14.00Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
13.89Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
13.79Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
13.79Single4QINSAG1.54QIN-SMO-SAG1.5
13.79Single5U09Taranabant5U09-CB1-Taranabant
13.79Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
13.79Single6OYAAll-trans-retinal6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
13.79Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;1
13.79Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
13.79Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
13.79Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
13.79Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
13.79Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
13.79Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
13.79Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
13.79Consensus5ht2c_onOrthosteric Ligand8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.79Consensusclass-f_offOrthosteric Ligandsmo_off
13.79Consensusffa3_on_alloOrthosteric Ligand8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
13.79Consensusgt_class-aOrthosteric Ligandgt_opsin
13.79Consensusgt_opsinOrthosteric Ligandgt_sensory
13.79Consensusgt_sensoryOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
13.33Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
13.33Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
13.33Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2
13.33Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
13.33Single7VODCariprazine7VOD-5-HT2A-Cariprazine
13.33Single7VV6C48/807VV6-MRGPRX2-C48/80
13.33Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
13.33Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.33Single8GCML9026888GCM-EP4-L902688-Gi1/&β;1/&γ;2
13.33Single8K2WAMG4878K2W-CXCR3-AMG487
13.33Consensusgi_class-fOrthosteric Ligandgi_frizzled
13.33Consensusgi_frizzledOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
13.33Consensussensory_offOrthosteric Ligandopsin_off
12.90Single5DSGTiotropium5DSG-M4-Tiotropium
12.90Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
12.90Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
12.90Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.90Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
12.90Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
12.90Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/&β;1/&γ;2
12.90Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
12.90Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
12.82Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
12.82Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
12.82Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
12.82Consensusclass-d_onOrthosteric Ligandste2_on
12.82Consensusgi_class-dOrthosteric Ligandgi_ste
12.82Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
12.50Single4WW3All-trans-retinal4WW3-Rhodopsin-All-trans-retinal
12.50Single5CGCHTL142425CGC-mGlu5-HTL14242
12.50Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
12.50Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
12.50Single8GDCPGE28GDC-EP3-PGE2-Gi1/&β;1/&γ;2
12.50Consensusccr2_off_alloOther Ligand5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
12.50Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
12.50Consensusep3_onOrthosteric Ligand8GDC-EP3-PGE2-Gi1/&β;1/&γ;2
12.12Single7EPENAM5637EPE-mGlu-NAM563
12.12Single8GDBPGE28GDB-EP4-PGE2-Gs/&β;1/&γ;2
12.12Single8X79MRE-2698X79-I2-MRE-269-Gs/&β;1/&γ;2
12.00Single8WCBCyclohexylammonium ion8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.00Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
11.76Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
11.76Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1
11.76Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
11.76Consensusprostanoid_onOrthosteric Ligandep_on fpa_on
11.63Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
11.54Consensusgabab_offOther Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
11.43Single5CGDHTL142425CGD-mGlu5-HTL14242
11.43Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
11.43Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
11.43Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2
11.43Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.43Consensusadgrg2_onOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
11.43Consensuscyslt2_offOrthosteric Ligand6RZ6-CysLT2-ONO-2570366 6RZ9-CysLT2-ONO-2770372 6RZ8-CysLT2-ONO-2080365
11.43Consensuscyslt_offOrthosteric Ligandcyslt2_off
11.43Consensusep2_onOrthosteric Ligand7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
11.11Single7MTBAll-trans-retinal7MTB-Rhodopsin-All-trans-retinal-GRK1
11.11Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/&β;1/&γ;2
11.11Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.11Consensussensory_onOrthosteric Ligandopsin_on
10.81Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
10.71Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
10.71Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
10.71Single6LI0GTPL98046LI0-GPR52-GTPL9804
10.71Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
10.71Single7MT8All-trans-retinal7MT8-Rhodopsin-All-trans-retinal-GRK1
10.71Single7MT9All-trans-retinal7MT9-Rhodopsin-All-trans-retinal-GRK1
10.71Single7MTAAll-trans-retinal7MTA-Rhodopsin-All-trans-retinal-GRK1
10.71Single8F76-8F76-OR51E2-Gs/&β;1/&γ;2
10.71Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
10.71Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/&β;1/&γ;2
10.71Consensusadgrg3_onOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
10.71Consensusopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
10.34Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
10.34Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
10.34Single2G87All-trans-retinal2G87-Rhodopsin-All-trans-retinal
10.34Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
10.34Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
10.34Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
10.34Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
10.34Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
10.34Consensussmo_on_alloOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
10.00Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
10.00Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
10.00Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
10.00Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
10.00Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
10.00Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
10.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
10.00Single8A6CAll-trans-retinal8A6C-Rhodopsin-All-trans-retinal
10.00Single8A6DAll-trans-retinal8A6D-Rhodopsin-All-trans-retinal
10.00Single8A6EAll-trans-retinal8A6E-Rhodopsin-All-trans-retinal
10.00Single8DWHCompound-168DWH-MRGPRX1-Compound-16-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.00Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
10.00Consensusopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
10.00Consensussmo_on_alloOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
9.68Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
9.68Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
9.68Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
9.68Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
9.68Single7VVOPTH7VVO-PTH1-PTH-Gs/&β;1/&γ;2
9.68Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
9.68Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
9.68Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.68Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
9.38Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
9.38Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
9.09Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
9.09Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
8.82Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
8.82Single7P2L4YI7P2L-mGlu5-4YI
8.82Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.82Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
8.33Single7CX2PGE27CX2-EP2-PGE2-Gs/&β;1/&γ;2
7.69Single6W25Ca6W25-MC4-SHU9119-Ca
7.55Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
7.41Single3PXOAll-trans-retinal3PXO-Rhodopsin-All-trans-retinal
7.41Single5DYSAll-trans-retinal5DYS-Rhodopsin-All-trans-retinal
7.41Single7XKEBetahydroxyandrosterone7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
7.41Single8HSCFab0468HSC-GPR20-Fab046-Gi1/&β;1/&γ;2
7.41Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
7.41Consensusclass-c_onOther Ligandgabab_on mglu_on
7.14Single2HPYAll-trans-retinal2HPY-Rhodopsin-All-trans-retinal
7.14Single6OY9All-trans-retinal6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
7.14Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
7.14Single7VDMSubstance P7VDM-MRGPRX2-Substance P-Gi1/&β;1/&γ;2
7.14Single7XKDBetahydroxyandrosterone7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
6.90Single3PQRAll-trans-retinal3PQR-Rhodopsin-All-trans-retinal-Gt(CT)
6.90Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
6.90Single7S8O(R)-Zinc-35737S8O-MRGPRX2-(R)-Zinc-3573-Gi1/&β;1/&γ;2
6.67Single3AYMAll-trans-retinal3AYM-Rhodopsin-All-trans-retinal
6.67Single7S8N(R)-Zinc-35737S8N-MRGPRX2-(R)-Zinc-3573-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.67Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
6.67Single7XKFBetahydroxyandrosterone7XKF-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
6.67Single8X2K5YM8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
6.52Single7TYLAmylin7TYL-CT-Amylin-Gs/&β;1/&γ;2
6.52Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
6.45Single8U8FPML8U8F-GPR3-PML-Gs/&β;1/&γ;2
6.38Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
6.25Single6FFIMMPEP6FFI-mGlu5-MMPEP
6.25Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
6.25Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
6.12Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
6.12Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
6.06Single6FFHFenobam6FFH-mGlu5-Fenobam
5.88Single8F2APramlintide analogue san3858F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
5.71Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
5.71Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
5.71Consensusmglu2_onOther Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
5.66Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
5.56Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
5.36Single8F0JPramlintide analogue san458F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2
5.00Single7SHEPI; PE7SHE-GPR158-PI; PE
4.26Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
4.26Single7TYIAmylin7TYI-CT-Amylin-Gs/&β;1/&γ;2
4.26Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/&β;1/&γ;2; RAMP2
4.17Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
4.17Single6D35Cholesterol6D35-SMO-Cholesterol
4.17Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
4.17Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
4.17Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
4.17Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
4.17Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
4.17Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
4.17Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
4.17Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-PubChem 7023848
4.17Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
4.17Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626-Phospholipid
4.17Single7DD5Ca37DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
4.17Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
4.17Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
4.17Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
4.17Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
4.17Single7DTTCa7DTT-CaS-Ca-Ca
4.17Single7DTTCa7DTT-CaS-Ca-Ca
4.17Single7DTUTryptophan7DTU-CaS-Tryptophan
4.17Single7DTUTryptophan7DTU-CaS-Tryptophan
4.17Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
4.17Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
4.17Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
4.17Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
4.17Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.17Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.17Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.17Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.17Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
4.17Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
4.17Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
4.17Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
4.17Single7EB2Baclofen7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
4.17Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
4.17Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
4.17Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
4.17Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
4.17Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
4.17Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
4.17Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
4.17Single7FIIhCG7FII-LH-hCG-6fuf
4.17Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
4.17Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
4.17Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
4.17Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
4.17Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.17Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.17Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.17Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.17Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
4.17Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
4.17Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
4.17Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
4.17Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
4.17Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
4.17Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
4.17Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
4.17Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
4.17Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
4.17Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.17Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.17Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.17Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.17Single7T9NM22 Fab7T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
4.17Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
4.17Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
4.17Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
4.17Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
4.17Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
4.17Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
4.17Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
4.17Single7XW7K1-707XW7-TSH-K1-70
4.17Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
4.17Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
4.17Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
4.17Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
4.17Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
4.17Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
4.17Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
4.17Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
4.17Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
4.17Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
4.17Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
4.17Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
4.17Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-J9R
4.17Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
4.17Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
4.17Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
4.17Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
4.17Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
4.17Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
4.17Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
4.17Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
4.17Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
4.17Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
4.17Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
4.17Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
4.17Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
4.17Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
4.17Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
4.17Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
4.17Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
4.17Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
4.17Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
4.17Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
4.17Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
4.17Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
4.17Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
4.17Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
4.17Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
4.17Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
4.17Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
4.17Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
4.17Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
4.17Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.17Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.17Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.17Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.17Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.17Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.17Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
4.17Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
4.17Consensusclass-c_offOrthosteric Ligandgabab_off mglu_off
4.17Consensusclass-c_offOrthosteric Ligandgabab_off mglu_off
4.17Consensusclass-c_offOther Ligandgabab_off mglu_off
4.17Consensusclass-c_onOrthosteric Ligandgabab_on mglu_on
4.17Consensusclass-c_onOrthosteric Ligandgabab_on mglu_on
4.17Consensusfsh_on_alloOrthosteric Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
4.17Consensusgabab_offOrthosteric Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
4.17Consensusgabab_onOrthosteric Ligand7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
4.17Consensusgi_class-cOrthosteric Ligandgi_mglu gi_gaba
4.17Consensusgi_class-cOrthosteric Ligandgi_mglu gi_gaba
4.17Consensusgi_gabaOrthosteric Ligand7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
4.17Consensusgi_mgluOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
4.17Consensusgi_mgluOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
4.17Consensusgphr_onOrthosteric Ligandlh_on tsh_on
4.17Consensusgs_gphrOrthosteric Ligand7T9I-TSH-TSH-Gs/&β;1/&γ;2 7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
4.17Consensusgs_proteinOrthosteric Ligandgs_gphr
4.17Consensuslh_onOrthosteric Ligand7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
4.17Consensuslh_on_alloOrthosteric Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
4.17Consensusmglu2_offOrthosteric Ligand7MTQ-mGlu2; mGlu2-LY341495
4.17Consensusmglu2_offOrthosteric Ligand7MTQ-mGlu2; mGlu2-LY341495
4.17Consensusmglu2_onOrthosteric Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
4.17Consensusmglu2_onOrthosteric Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
4.17Consensusmglu3_offOrthosteric Ligand7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
4.17Consensusmglu3_offOrthosteric Ligand7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
4.17Consensusmglu4_onOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
4.17Consensusmglu4_onOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
4.17Consensusmglu5_offOrthosteric Ligand7FD9-mGlu5; mGlu5-LY341495
4.17Consensusmglu5_offOrthosteric Ligand7FD9-mGlu5; mGlu5-LY341495
4.17Consensusmglu_offOrthosteric Ligandmglu2_off mglu3_off mglu5_off
4.17Consensusmglu_offOrthosteric Ligandmglu2_off mglu3_off mglu5_off
4.17Consensusmglu_onOrthosteric Ligandmglu2_on mglu4_on
4.17Consensusmglu_onOrthosteric Ligandmglu2_on mglu4_on
4.17Consensussmo_off_alloOther Ligand6D32-SMO-Cyclopamine-Cyclopamine
4.17Consensustsh_onOrthosteric Ligand7T9I-TSH-TSH-Gs/&β;1/&γ;2
4.17Consensustsh_on_alloOrthosteric Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
4.08Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
4.00Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.00Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.00Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.00Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.00Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.00Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
4.00Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
3.85Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
3.85Single7T9MCS-17 Antibody7T9M-TSH-CS-17 Antibody
3.85Single8HS2Fab0468HS2-GPR20-Fab046
3.70Single4A4MAll-trans-retinal4A4M-Rhodopsin-All-trans-retinal-Gt(CT)
3.70Single5EN0All-trans-retinal5EN0-Rhodopsin-All-trans-retinal-Gt(CT)
3.70Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
3.70Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
3.70Single7UTZTR14027UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
3.70Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
3.70Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
3.70Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
3.70Consensusccr8_offOrthosteric Ligand8TLM-CCR8-Anti-murine CCR8 antibody
3.64Single8F2BPramlintide analogue san458F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
3.57Single5L7DCholesterol5L7D-SMO-Cholesterol
3.57Single7T9ITSH7T9I-TSH-TSH-Gs/&β;1/&γ;2
3.57Single8I2GGlycoprotein hormones alpha chain8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
3.45Single7Y14Beta-alanine7Y14-MRGPRD-Beta-alanine
3.33Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
3.33Single7Y12Beta-alanine7Y12-MRGPRD-Beta-alanine-Gi1/&β;1/&γ;2
3.33Consensusgip_on_alloOther Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
3.12Single8G94CD698G94-S1P1-CD69-Gi1/&β;1/&γ;2
3.03Single8IYXYL-3658IYX-GPR34-YL-365
2.70Single7SHEPI; PE7SHE-GPR158-PI; PE
2.63Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
2.44Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
2.00Single8F0KPramlintide analogue san3858F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3

Consensus Members
Id Members
gs_cck 7MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1
7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
gs_motilin 8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
gs_neuromedin 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
gs_orexin 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
gs_sst 7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
gs_tachykinin 8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
gs_trh 7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
gs_vasopressin-ot 7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
gs_bombesin 8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
gs_bradykinin 7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
gs_compl-peptide 8I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
gs_endothelin 8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
gs_galanin 7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
gs_ghrelin 7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
gs_melanocortin 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
7F58-MC4-THIQ-Gs/&β;1/&γ;2
Net Summary
Imin 2.84497
Number of Linked Nodes 968
Number of Links 1127
Number of Hubs 162
Number of Links mediated by Hubs 655
Number of Communities 20
Number of Nodes involved in Communities 206
Number of Links involved in Communities 289
Path Summary
Number Of Nodes in MetaPath 110
Number Of Links MetaPath 109
Number of Shortest Paths 2601692
Length Of Smallest Path 3
Average Path Length 29.1683
Length of Longest Path 52
Minimum Path Strength 0.455937
Average Path Strength 5.44461
Maximum Path Strength 19.3147
Minimum Path Correlation 0.700111
Average Path Correlation 0.967598
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.08333
Average % Of Corr. Nodes 34.5387
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 44.9562
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following consensuses:
IdComponents
gs_class-ags_amine
gs_nucleotide
gs_lipid
gs_peptide
gs_protein
gs_steroid



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