Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
1G.HN.29 2.58076402
2G.S1.02 5.43326436
3G.s1h1.04 4.33094139
4G.H1.01 4.31296639
5G.H1.11 2.43993409
6G.S2.08 4.98667436
7G.S3.01 3.86736435
8G.S3.03 5.64569638
9G.S3.04 9.40854417
10G.S3.06 9.88354417
11G.H2.01 5.82688409
12G.H2.06 5.21369719
13G.H2.07 5.84931619
14G.H2.10 4.99625418
15G.h2s4.01 9.49861409
16G.S4.04 4.39625409
17G.S4.05 3.96178537
18G.S4.07 5.959174138
19G.H3.01 3.046166139
20G.H3.09 5.11256199
21G.H3.13 8.533476196
22G.H3.17 8.58662615
23G.S5.04 4.79722409
24G.S5.05 4.33556739
25G.S5.07 3.8925639
26G.HG.01 6.28354476
27G.HG.03 4.05778406
28G.hgh4.04 3.142014216
29G.hgh4.05 12.1383406
30G.hgh4.11 3.75117505
31G.hgh4.20 6.83361573
32G.H4.03 3.44132404
33G.H4.08 7.69743473
34G.H4.10 10.03885217
35G.H4.12 6.81239574
36G.H4.15 7.28153408
37G.h4s6.20 5.792785114
38G.S6.01 3.60042405
39G.S6.02 7.462335118
40G.S6.05 8.34672575
41G.s6h5.01 5.99722439
42G.H5.03 4.88694439
43G.H5.05 4.86228535
44G.H5.06 8.15394534
45G.H5.08 5.10405738
46G.H5.12 3.99049437
47G.H5.17 7.735615115
48G.H5.23 5.78285404
49G.H5.24 3.61333406
50b.1x1 2.61208404
51b.1x11 2.92722408
52b.1x15 3.23292407
53b.lhb1x3 3.79594502
54b.lhb1x6 4.064785143
55b.b1x4 3.341184127
56b.l1x3 9.54078559
57b.l1x6 10.0947519
58b.b2x1 6.39533518
59b.b2x3 4.13806556
60b.b2x5 6.23954657
61b.l3x1 8.43118419
62b.l3x2 6.339615179
63b.b4x6 8.93623759
64b.b5x2 7.26375407
65b.b5x3 6.0838659
66b.b5x5 5.18139405
67b.b5x7 5.54958407
68b.l5x1 4.788785238
69b.l5x5 7.97477619
70b.b6x1 5.77208419
71b.b6x5 4.548476226
72b.l6x5 6.954794154
73b.b7x1 6.855494154
74b.b7x2 3.53664228
75b.l7x4 4.88243409
76b.b8x4 5.55989506
77b.l8x3 3.177924253
78b.l8x5 4.669864253
79b.l9x3 9.1375419
80b.l9x6 5.79623718
81b.b10x5 4.94578509
82b.l10x1 4.10375403
83b.b11x2 5.10854407
84b.b11x4 5.68792419
85b.l11x2 8.39007419
86b.b12x3 3.85493468
87b.b12x6 8.02385718
88b.b13x7 8.26411567
89b.l13x3 8.88472569
90b.l13x6 6.37257419
91b.l13x7 4.28628569
92b.b14x3 4.05125465
93b.b15x1 6.75037669
94b.b15x3 4.97469
95b.l15x1 6.18521417
96b.l15x2 6.53965469
97b.b16x4 9.054566
98b.b16x5 4.60313405
99b.b16x6 9.753568
100b.b16x7 7.22847409
101b.b17x5 6.79479447
102b.b17x7 8.46215448
103b.l17x3 9.00806649
104b.l17x6 7.84422519
105b.b18x3 5.17014448
106b.b18x5 5.30931405
107b.l18x1 5.885286166
108b.l18x2 6.207994167
109b.b19x2 7.37911546
110b.b19x4 5.40368448
111b.l19x1 5.84854419
112b.l19x2 7.76661549
113b.b20x2 6.92549446
114b.b20x4 9.2012648
115b.b20x6 7.36578546
116b.b20x7 4.88389409
117b.l20x2 8.09708409
118b.b21x1 8.48378547
119b.b21x5 5.46611404
120b.b21x7 6.93661505
121b.b22x5 5.342926167
122b.l22x5 7.138675149
123b.b23x1 3.86993405
124b.b23x6 6.48321717
125b.l23x1 6.02322516
126b.b24x4 8.3516416
127b.b24x6 6.93035418
128b.l24x3 6.1041405
129b.l25x3 8.85295599
130b.l25x6 12.2933518
131b.l27x1 10.0357719
132b.l27x2 7.71979499
133b.b28x3 5.14111557
134b.b28x4 7.97299496
135b.b28x6 9.739599
136g.h1x11 3.78347409
137g.l1x2 4.2375442
138g.l1x4 6.13222448
139g.ctx3 6.70104409
140g.ctx6 3.087226146
141g.ctx14 5.344034129
142g.ctx16 4.742467128
143Lig 7.571572920
1441x39 5.96828527
1451x46 3.94368408
1461x50 5.09372509
1471x53 3.158894109
1482x40 4.381676109
1492x42 4.62508
1502x46 3.95417489
1512x50 6.63528589
1522x51 2.48083407
1532x56 5.01597427
1542x60 4.81993427
155E1x50 5.4125428
1563x25 5.39174429
1573x28 2.47521406
1583x29 6.59326426
1593x30 3.124225266
1603x42 3.8734488
1613x50 5.97972489
1623x51 6.89799438
163I2x51 4.55067537
164I2x56 3.70757405
1654x61 4.90594527
166E2 11.14251123
1675x40 5.23722426
1685x47 6.25632428
1695x58 4.90433509
1705x62 1.864506
1715x64 3.5275436
1726x44 5.21417409
1736x48 6.30597628
1746x51 6.27667427
1756x52 7.08514427
1766x55 6.63854427
177E3 9.067471023
1787x34 5.67756525
1797x38 4.02597426
1807x42 4.56261527
1817x49 6.21222489
1827x53 5.27856589
1838x48 3.06389406
1848x50 4.006674109
185E1 0.728194400
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1b.b3x6 b.l1x3 10014.0636NoYes099
2b.b3x6 b.l3x2 99.89168.99695NoYes099
3b.b4x6 b.l1x3 51.89233.46472YesYes599
4b.l1x4 b.l3x2 98.744210.2558NoYes1769
5G.HN.51 b.l1x4 98.69386.04NoNo046
6G.HN.51 G.hns1.02 98.4755.50139NoNo044
7G.hns1.02 I2x54 98.255810.2639NoNo046
8b.b3x2 b.b4x6 27.11663.98889NoYes559
9b.b2x3 b.b3x2 23.36224.71222YesNo565
10b.b26x2 b.b2x3 95.15515.44528NoYes076
11b.b26x1 b.b26x2 94.96323.29667NoNo097
12b.b26x1 b.l27x1 94.86754.63333NoYes099
13b.b28x3 b.b4x6 23.3664.65111YesYes579
14b.b28x3 b.b2x3 68.60063.53333YesYes576
15b.b2x1 b.l27x1 72.6594.33917YesYes189
16I2x53 I2x54 98.14613.07083NoNo086
173x53 I2x53 91.92343.23833NoNo088
183x53 G.H5.19 30.29255.15806NoNo088
19G.H5.15 G.H5.19 29.98674.12417NoNo088
20G.H5.15 G.S1.02 18.06454.08778NoYes386
21G.S1.02 G.S3.03 17.76695.56222YesYes368
22G.H5.15 I2x51 11.76923.63611NoYes387
23G.S1.04 G.S3.03 17.02443.38389NoYes078
24G.S1.04 G.S4.03 16.86583.565NoNo077
25G.S4.03 G.S5.05 16.54423.105NoYes379
26b.b2x1 b.b6x1 69.41356.81639YesYes189
27b.b6x1 b.l9x6 69.23237.01417YesYes198
28G.H2.07 b.l9x6 29.56553.42917YesYes198
29G.H2.04 G.H2.07 29.13977.88861NoYes099
30G.H2.04 G.H3.08 28.99777.69778NoNo098
31G.H3.17 b.l27x1 11.37156.74222YesYes159
32b.l25x6 b.l27x1 15.943820.1567YesYes189
33G.H3.08 G.S4.04 28.73754.20111NoYes089
34G.S4.04 G.S5.04 19.70693.34861YesYes099
35G.S5.07 G.s5hg.01 11.49415.01611YesNo099
36G.S5.06 G.S6.05 13.64584.02306NoYes085
37G.S5.04 G.S5.06 13.79355.49917YesNo098
38G.H4.10 G.hgh4.08 13.153311.9211YesNo076
39G.H4.13 G.hgh4.08 10.309410.9478NoNo036
40G.H4.12 G.H4.13 12.33086.51806YesNo043
41G.H3.17 b.l23x1 10.51687.35361YesYes156
42b.l23x1 b.l25x6 10.497113.4653YesYes168
433x53 G.H5.23 68.98575.20222NoYes084
443x50 G.H5.23 67.593910.5175YesYes094
453x50 7x53 45.20924.02778YesYes899
463x43 7x53 44.80314.01194NoYes889
472x46 3x43 13.0733.05389YesNo898
482x46 2x50 13.01355.50139YesYes899
491x50 2x50 20.11938.67694YesYes099
501x50 2x47 15.8492.87306YesNo099
511x53 2x47 15.53653.35333YesNo099
521x53 8x50 13.36433.15667YesYes1099
538x47 8x50 11.48784.69806NoYes1099
543x43 7x49 31.59355.33778NoYes889
552x50 7x49 12.89686.82139YesYes899
56b.l11x1 b.l9x6 42.02997.32111NoYes198
57b.b11x6 b.l11x1 42.00363.40167NoNo199
58b.b11x6 b.l9x3 41.288315.8853NoYes199
59b.b12x6 b.l9x3 40.76415.05389YesYes189
60b.b11x2 b.b12x6 39.8683.55278YesYes078
61b.b10x3 b.b11x2 36.47084.18278NoYes087
62b.b10x3 b.b6x2 36.33393.89639NoNo088
63b.b10x2 b.b6x2 36.19693.23917NoNo068
64b.b10x2 b.b14x3 34.90134.31722NoYes065
65b.b14x3 b.b15x1 31.81793.82417YesYes659
66b.b15x1 b.b16x6 29.832213.6414YesYes698
67b.b16x4 b.b16x6 14.91097.70111YesYes668
68b.b16x4 b.b17x6 14.666612.0106YesNo067
69b.b17x6 g.h1x14 14.52178.0775NoNo079
70b.1x15 g.h1x14 28.69772.73583YesNo079
71b.1x15 g.h1x11 10.34371.03167YesYes079
72b.b16x6 b.b17x3 14.75865.69528YesNo685
73b.b17x3 g.h1x10 14.61465.8075NoNo059
74g.h1x10 g.h1x14 14.46967.50222NoNo099
75b.1x15 b.1x19 17.64216.36611YesNo076
76b.1x19 b.b21x1 16.45512.5383NoYes067
77b.l21x7 b.l23x1 20.53633.24028NoYes156
78b.b23x6 b.l21x7 19.9353.69444YesNo175
79b.b23x6 b.b24x6 15.41525.28028YesYes178
80b.b21x7 b.b24x6 13.920811.175YesYes058
81b.l1x3 b.l1x7 22.62299.72389YesNo099
82b.b28x3 b.l1x7 22.62834.24056YesNo079
833x50 5x58 22.28356.11056YesYes099
843x47 5x58 20.05394.58278NoYes099
853x47 5x54 19.89944.10528NoNo098
865x54 6x44 19.75934.83083NoYes089
876x44 6x48 18.3578.59389YesYes098
883x36 6x48 30.90184.25333NoYes278
893x36 Lig 30.60734.81028NoYes270
907x45 7x49 18.84168.4725NoYes099
916x48 7x45 18.54711.1386YesNo089
92b.b3x4 b.l1x3 22.62087.70889NoYes599
93b.b28x3 b.b3x4 22.62716.09278YesNo579
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
E2Lig7.376942YesYes3010
2x64Lig4.594442NoYes6010
2x67Lig3.060282NoYes4010
E2x51Lig15.822NoYes4010
E3Lig12.04532YesYes3010
6x58Lig6.326942NoYes4010
6x55Lig11.00972YesYes7010
7x34Lig11.60922YesYes5010
2x60Lig8.432YesYes7010
3x29Lig8.235282YesYes6010
3x32Lig6.300832NoYes7010
4x61Lig8.72752YesYes7010
E2x52Lig3.156672NoYes5010
5x40Lig8.093332YesYes6010
3x33Lig3.259172NoYes6010
3x36Lig4.810282NoYes7010
5x43Lig3.330832NoYes7010
1x352x644.450NoNo4621
1x357x355.435560NoNo4521
1x392x573.880832YesNo7712
1x392x6111.27722YesNo7612
1x397x397.981112YesNo7712
1x397x423.57752YesYes7712
2x532x563.483610NoYes8721
2x563x324.966942YesNo7711
2x567x427.336672YesYes7712
2x577x425.282222NoYes7722
2x603x325.226942YesNo7711
2x607x423.12YesYes7712
E1x49E28.863330NoYes4321
3x25E1x506.516672YesYes9812
E1x50E2x505.122YesNo8922
3x25E2x504.853332YesNo9912
3x26E23.250NoYes5321
3x294x613.7352YesYes6711
3x294x6510.40672YesNo6612
3x334x575.283062NoNo6812
3x366x484.253332NoYes7812
4x61E2x524.126672YesNo7511
4x615x394.132YesNo7812
4x634x643.626670NoNo5521
4x64E28.450282NoYes5311
E2E235.79442YesYes3311
E2E2x5113.38332YesNo3411
5x36E24.528332NoYes5311
5x365x403.322NoYes5611
5x395x436.839720NoNo8721
5x406x554.024722YesYes6711
5x406x595.510832YesNo6612
6x486x524.822YesYes8722
6x487x415.578332YesNo8722
6x516x526.999722YesYes7712
6x516x557.443062YesYes7711
6x517x416.343062YesNo7712
6x54E33.612782NoYes5321
6x576x616.085832NoNo5422
6x57E316.03332NoYes5321
6x58E35.812222NoYes4311
6x61E312.52612NoYes4321
E3E315.48922YesYes3311
7x37E34.103332NoYes6321
7x347x384.223612YesYes5611
7x387x423.516672YesYes6712
3x25Lig6.200832YesYes9010
1x39Lig3.124722YesYes7010
7x35Lig4.078062NoYes5010
7x38Lig4.286942YesYes6010
6x51Lig4.320832YesYes7010
3x253x293.996112YesYes9611
3x334x613.810562NoYes6711
6x547x346.991672NoYes5521
6x547x373.708332NoNo5622
4x64Lig3.391112NoYes5010
2x56Lig4.276672YesYes7010
5x36Lig5.452NoYes5010
1x31Lig3.643332NoYes1010
2x67NT3.972NoNo4312
6x557x384.076672YesYes7611
7x34E34.473332YesYes5311
2x603x282.522782YesYes7612
1x317x322.466672NoNo1312
3x22E22.366672NoYes4321
5x425x431.973330NoNo5721
1x281x311.810NoNo0121
5x35E21.446672NoYes4321
5x34E21.313332NoYes2321
7x317x341.092NoYes3521
7x31E31.092NoYes3321
2x642x680.3894442NoNo6012
3x18Lig0.3080560NoYes0010

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
64.29Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
61.29Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
60.61Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
60.61Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
59.38Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
56.25Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
55.17Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
54.05Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
54.05Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
53.33Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
51.85Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
51.72Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
51.72Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
51.72Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
51.72Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
51.61Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
51.61Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
51.61Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
51.61Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
51.61Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
51.61Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
51.61Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
51.61Consensusvasop-oxy_onOrthosteric Ligandv2_on
51.61Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
51.52Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
51.52Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
51.52Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
51.52Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
50.00Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
50.00Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
50.00Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
50.00Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
50.00Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
50.00Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
48.57Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
48.57Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
48.57Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
48.48Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
48.48Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
48.48Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
48.39Single6W25SHU91196W25-MC4-SHU9119-Ca
48.39Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
48.39Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
48.39Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
48.39Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
48.28Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
47.06Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
47.06Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
47.06Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
46.88Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
46.88Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
46.88Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
46.67Single8WKYPG-9348WKY-MC4-PG-934
46.67Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
46.67Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
46.51Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
46.43Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
45.45Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
45.45Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
45.45Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
45.45Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
45.45Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
45.16Single3QAKUK-4320973QAK-A2A-UK-432097
45.16Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
45.16Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
45.16Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
44.83Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
44.83Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
44.83Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
44.83Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
44.12Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
44.12Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
44.12Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
43.75Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
43.75Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
43.75Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
43.75Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
43.75Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
43.33Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
43.33Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
43.33Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
43.33Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
43.33Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
43.33Single8QJ2pN1628QJ2-MC4-pN162-Gs
43.33Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
43.33Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
42.86Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
42.86Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
42.86Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
42.86Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
42.86Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
42.42Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
42.42Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
42.42Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
42.42Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
42.42Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
42.42Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
42.42Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
42.42Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
41.94Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
41.94Single7F8XNN90567F8X-CCKA-NN9056
41.94Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
41.94Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
41.94Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
41.94Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
41.67Single6IGLIRL16206IGL-ETB-IRL1620
41.67Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
41.67Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
41.67Consensusbradykinin_onOrthosteric Ligandbk2_on
41.67Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
41.67Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
41.38Single4RWADIPP-NH24RWA-δ-DIPP-NH2
41.38Single6MXTSalmeterol6MXT-β2-Salmeterol
41.38Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
41.38Single8XYIVUF106618XYI-CXCR3-VUF10661
41.18Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
41.18Single8ZRTET-18ZRT-ETB-ET-1
41.18Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
41.18Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
41.18Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
41.03Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
40.62Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
40.62Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
40.62Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
40.62Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
40.62Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
40.62Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
40.62Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
40.62Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
40.62Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
40.62Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
40.54Single5GLHEndothelin-15GLH-ETB-Endothelin-1
40.54Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
40.00Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
40.00Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
40.00Single7EZCUKA7EZC-A2A-UKA
40.00Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
40.00Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
40.00Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
40.00Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
40.00Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
40.00Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
40.00Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
40.00Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
40.00Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
40.00Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
40.00Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
40.00Consensuscck_onOrthosteric Ligandccka_on cckb_on
40.00Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
40.00Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
40.00Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
40.00Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
40.00Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
40.00Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
39.39Single3OE0CVX153OE0-CXCR4-CVX15
39.39Single5WF5UK-4320975WF5-A2A-UK-432097
39.39Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
39.39Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
39.39Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
39.39Consensusangiotensin_onOrthosteric Ligandat1_on
39.39Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
39.39Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
39.39Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
39.29Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
39.29Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
39.29Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
39.29Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
39.29Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
38.89Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
38.71Single4UG2CGS216804UG2-A2A-CGS21680
38.71Single5WF6UK-4320975WF6-A2A-UK-432097
38.71Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
38.71Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
38.71Single7XN9L-054,5227XN9-SST2-L-054,522
38.71Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
38.71Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
38.71Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
38.71Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
38.71Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
38.71Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
38.71Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
38.71Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
38.46Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
38.24Single6JODAngiotensin II6JOD-AT2-Angiotensin II
38.24Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
38.24Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
38.24Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
38.24Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
38.24Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
38.24Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
37.93Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
37.93Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
37.93Single7TUYGSK682753A7TUY-GPR183-GSK682753A
37.93Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
37.93Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
37.93Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
37.93Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
37.93Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
37.84Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
37.84Consensusendothelin_onOrthosteric Ligandetb_on eta_on
37.50Single4IARErgotamine4IAR-5-HT1B-Ergotamine
37.50Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
37.50Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
37.50Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
37.50Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
37.50Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
37.50Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
37.50Single8KIGSHU91198KIG-MC3-SHU9119-Ca
37.50Single8WDTphotoNECA8WDT-A2A-photoNECA
37.50Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
37.50Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
37.50Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
37.50Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
37.50Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
37.50Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
37.50Consensuslpl_onOrthosteric Ligands1p_on lpa_on
37.50Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
37.50Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
37.50Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
37.50Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
37.50Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
37.50Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
37.14Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
37.14Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
37.14Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
37.14Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
37.14Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
37.04Single4MBSMaraviroc4MBS-CCR5-Maraviroc
37.04Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
36.84Single6IGKEndothelin-36IGK-ETB-Endothelin-3
36.84Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
36.84Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
36.84Consensusbombesin_onOrthosteric Ligandbb2_on
36.84Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
36.84Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
36.67Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
36.67Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
36.67Single7YITNalfurafine7YIT-κ-Nalfurafine
36.67Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
36.67Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
36.67Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
36.67Single8JJLOlodaterol8JJL-β2-Olodaterol
36.67Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
36.67Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
36.67Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
36.67Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
36.67Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
36.67Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
36.67Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
36.67Consensusorexin_onOrthosteric Ligandox2_on
36.67Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
36.67Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
36.36Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
36.36Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
36.36Single7XNACYN1548067XNA-SST2-CYN154806
36.36Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
36.36Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
36.36Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
36.36Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
36.36Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
36.36Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
36.36Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
36.36Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
36.36Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
36.36Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
36.11Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
36.11Single7SK3CXCL127SK3-ACKR3-CXCL12
36.11Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
36.11Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
35.90Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
35.90Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
35.71Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
35.71Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
35.71Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
35.71Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
35.71Consensusa3_onOrthosteric Liganda3a_on
35.71Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
35.71Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
35.71Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
35.48Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
35.48Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
35.48Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
35.48Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
35.48Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
35.48Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
35.48Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
35.48Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
35.48Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
35.48Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
35.48Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
35.48Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/β1/γ2
35.48Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
35.48Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
35.48Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
35.48Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
35.48Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
35.29Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
35.29Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
35.29Single6PT2KGCHM076PT2-δ-KGCHM07
35.29Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
35.29Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
35.29Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
35.29Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
35.29Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
35.29Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
35.29Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
35.29Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
35.29Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
35.29Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
35.29Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
35.29Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
35.29Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
35.14Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
34.48Single5N2RPSB-365N2R-A2A-PSB-36-Na
34.48Single5N2SPSB365N2S-A1-PSB36
34.48Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
34.48Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
34.48Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
34.48Single7C61Ergotamine7C61-5-HT1B-Ergotamine
34.48Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
34.48Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/β1/γ2
34.48Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
34.48Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
34.48Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
34.48Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
34.48Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
34.48Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
34.48Single8QOTNanobody-E8QOT-μ-Nanobody-E
34.48Single8TF5Oleic acid8TF5-GPR6-Oleic acid
34.48Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
34.48Single8XYKVUF106618XYK-CXCR3-VUF10661-Go1/β1/γ2
34.48Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
34.48Consensusa3_on_gpOrthosteric Liganda3a_on_gp
34.48Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
34.48Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
34.48Consensusadenosine_offOrthosteric Liganda1_off a2_off
34.48Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
34.48Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
34.48Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
34.38Single3NY9ICI118-5513NY9-β2-ICI118-551
34.38Single5ZTYAM102575ZTY-CB2-AM10257
34.38Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
34.38Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
34.38Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
34.38Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
34.38Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
34.38Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
34.38Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
34.38Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
34.38Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
34.38Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
34.29Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
34.29Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
34.29Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
34.29Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
34.29Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
34.29Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
34.29Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
34.29Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
34.29Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
34.29Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
34.21Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
34.21Single8IY6Endothelin-18IY6-ETB-Endothelin-1
34.21Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
34.21Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single3P0GBI1671073P0G-β2-BI167107
33.33Single3PWHZM-2413853PWH-A2A-ZM-241385
33.33Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
33.33Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
33.33Single4XT1Fractalkine4XT1-US28-Fractalkine
33.33Single5XR8AM8415XR8-CB1-AM841
33.33Single5XRAAM115425XRA-CB1-AM11542
33.33Single6AKXA4R6AKX-CCR5-A4R
33.33Single6AKYMaraviroc6AKY-CCR5-Maraviroc
33.33Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
33.33Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
33.33Single6J20Aprepitant6J20-NK1-Aprepitant
33.33Single6J21Aprepitant6J21-NK1-Aprepitant
33.33Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
33.33Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
33.33Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
33.33Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
33.33Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single7FEECP559407FEE-CB1-CP55940-ZCZ011
33.33Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
33.33Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
33.33Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
33.33Single7PX4PSB-21137PX4-A2A-PSB-2113
33.33Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
33.33Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
33.33Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
33.33Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
33.33Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
33.33Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
33.33Single8E0GBU728E0G-μ-BU72
33.33Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
33.33Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
33.33Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
33.33Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
33.33Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
33.33Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
33.33Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
33.33Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
33.33Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
33.33Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
33.33Single8XWNCXCL88XWN-CXCR2-CXCL8
33.33Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
33.33Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
33.33Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
33.33Consensusa2_onOrthosteric Liganda2b_on
33.33Consensusa2_on_gpOrthosteric Liganda2b_on_gp
33.33Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
33.33Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
33.33Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
33.33Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
33.33Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
33.33Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
33.33Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
33.33Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
33.33Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
33.33Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
33.33Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
33.33Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
33.33Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
33.33Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
33.33Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
33.33Consensusorexin_offOrthosteric Ligandox2_off ox1_off
33.33Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
33.33Consensussomatostatin_offOrthosteric Ligandsst2_off
33.33Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
32.50Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
32.50Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
32.43Single4XT3Fractalkine4XT3-US28-Fractalkine
32.43Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
32.43Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
32.43Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
32.43Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
32.35Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
32.35Single6HLOAprepitant6HLO-NK1-Aprepitant
32.35Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
32.35Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
32.35Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
32.35Single7SK5CXCL127SK5-ACKR3-CXCL12
32.35Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
32.35Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
32.35Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
32.35Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
32.35Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
32.35Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
32.35Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
32.26Single4LDEBI1671074LDE-β2-BI167107
32.26Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
32.26Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
32.26Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
32.26Single6KQICP559406KQI-CB1-CP55940-Org27569
32.26Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
32.26Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
32.26Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
32.26Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
32.26Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
32.26Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
32.26Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
32.26Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
32.26Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
32.26Single8JJ8Formoterol8JJ8-β2-Formoterol
32.26Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
32.26Single8JWY2-1188JWY-A2A-2-118
32.26Single8JWZAB9288JWZ-A2A-AB928-Na
32.26Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
32.26Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
32.26Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
32.26Single8ZPLHF511168ZPL-CXCR4-HF51116-Cholesterol
32.26Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
32.26Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
32.26Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
32.26Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
32.26Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
32.26Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
32.26Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
32.26Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
32.26Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
32.26Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
32.26Consensuslpa_offOrthosteric Ligandlpa1_off
32.26Consensuslpl_offOrthosteric Ligands1p_off lpa_off
32.26Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
32.26Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
32.26Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
32.14Single4ZJCSB-6740424ZJC-OX1-SB-674042
32.14Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
32.14Single5IUBQ274563445IUB-A2A-Q27456344-Na
32.14Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
32.14Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
32.14Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
32.14Single7AROLUF58337ARO-A2A-LUF5833-Na
32.14Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
32.14Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
32.14Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
32.14Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
32.14Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
32.14Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
32.14Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
32.14Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
32.14Single8K5CAcipimox8K5C-HCA2-Acipimox
32.14Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
32.14Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
32.14Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
32.14Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
32.14Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
32.14Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
32.14Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
32.14Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
32.14Consensushca_onOrthosteric Ligandhca2_on
31.58Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
31.58Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
31.58Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
31.43Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
31.43Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
31.43Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
31.43Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
31.43Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
31.43Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
31.43Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
31.43Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
31.43Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
31.43Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
31.25Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
31.25Single6IBLArformoterol6IBL-β1-Arformoterol
31.25Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
31.25Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
31.25Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
31.25Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
31.25Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
31.25Single7UM4AS26747237UM4-5-HT5A-AS2674723
31.25Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
31.25Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
31.25Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
31.25Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
31.25Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
31.25Consensuschemerin_onOrthosteric Ligandcml1_on
31.25Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
31.25Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
31.25Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
31.25Consensusprostanoid_offOrthosteric Ligandep_off dp_off
31.03Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
31.03Single4EJ4Naltrindole4EJ4-δ-Naltrindole
31.03Single4YAYZD-71554YAY-AT1-ZD-7155
31.03Single5IU8Q274563475IU8-A2A-Q27456347-Na
31.03Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
31.03Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
31.03Single5UENDU1725UEN-A1-DU172
31.03Single5UIGCmpd-15UIG-A2A-Cmpd-1
31.03Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
31.03Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
31.03Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
31.03Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
31.03Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
31.03Single7PYRPSB-21157PYR-A2A-PSB-2115
31.03Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
31.03Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
31.03Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
31.03Single7UL4Alvimopan7UL4-μ-Alvimopan
31.03Single7V3ZCP559407V3Z-CB1-CP55940
31.03Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
31.03Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
31.03Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
31.03Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
31.03Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
31.03Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
31.03Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
31.03Single8RLNLUF58348RLN-A2A-LUF5834
31.03Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
31.03Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.03Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.03Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.03Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
31.03Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
31.03Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
31.03Single9CHXS-Carazolol9CHX-β2-S-Carazolol
31.03Consensuscck_offOrthosteric Ligandccka_off
31.03Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
31.03Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
31.03Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
31.03Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
31.03Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
31.03Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
31.03Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
31.03Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
31.03Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
31.03Consensushca_on_gpOrthosteric Ligandhca2_on_gp
31.03Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
30.77Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
30.56Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
30.56Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
30.56Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
30.56Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
30.56Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
30.56Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
30.30Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
30.30Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
30.30Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
30.30Single6PT3DPI-2876PT3-δ-DPI-287
30.30Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
30.30Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
30.30Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
30.30Single7SK9CCX6627SK9-ACKR3-CCX662
30.30Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
30.30Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
30.30Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
30.30Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
30.30Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
30.30Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
30.30Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
30.00Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
30.00Single5C1MBU725C1M-μ-BU72
30.00Single5IUAQ274563485IUA-A2A-Q27456348-Na
30.00Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
30.00Single5WQCEMPA5WQC-OX2-EMPA
30.00Single5X7DS-Carazolol5X7D-β2-S-Carazolol-PubChem 129318963
30.00Single6D26Fevipiprant6D26-DP2-Fevipiprant
30.00Single6E67BI1671076E67-β2-BI167107-Gs (fused)
30.00Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
30.00Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
30.00Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
30.00Single6S0QZM-2413856S0Q-A2A-ZM-241385
30.00Single6TP6Filorexant6TP6-OX1-Filorexant
30.00Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
30.00Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
30.00Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
30.00Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
30.00Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
30.00Single7W41PD1762527W41-BB2-PD176252
30.00Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
30.00Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
30.00Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
30.00Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
30.00Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
30.00Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
30.00Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
30.00Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
30.00Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
30.00Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
30.00Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.00Single8GNEKW-63568GNE-A2A-KW-6356-Na
30.00Single8JXSPF-61428JXS-D1-PF-6142
30.00Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
30.00Single8S4DCMF-0198S4D-Apelin-CMF-019
30.00Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.00Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.00Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
30.00Single8WGBW9R8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
30.00Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
30.00Consensusbombesin_offOrthosteric Ligandbb2_off
30.00Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
30.00Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
30.00Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
30.00Consensusdp_offOrthosteric Liganddp2_off
30.00Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
30.00Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
30.00Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
30.00Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
29.73Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
29.73Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
29.73Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
29.73Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
29.73Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
29.73Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
29.73Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
29.73Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
29.63Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
29.63Single6HLLCP999946HLL-NK1-CP99994
29.63Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
29.63Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
29.63Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
29.63Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
29.41Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
29.41Single7QA8Peptide7QA8-STE2-Peptide
29.41Single7QA8Peptide7QA8-STE2-Peptide
29.41Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
29.41Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
29.41Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
29.41Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
29.41Single8IEBA1LYA8IEB-GPR156-A1LYA
29.41Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/β1/γ2
29.41Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
29.41Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
29.41Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
29.41Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
29.03Single2YDVNECA2YDV-A2A-NECA
29.03Single4DJHJDTic4DJH-κ-JDTic
29.03Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
29.03Single4UHRCGS216804UHR-A2A-CGS21680
29.03Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
29.03Single5G53NECA5G53-A2A-NECA-Gs
29.03Single6E59L-7607356E59-NK1-L-760735
29.03Single6H7JIsoprenaline6H7J-β1-Isoprenaline
29.03Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
29.03Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
29.03Single6TQ7SB-3348676TQ7-OX1-SB-334867
29.03Single6WGTLSD6WGT-5-HT2A-LSD
29.03Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
29.03Single7B6WCyclazosin7B6W-α1b-Cyclazosin
29.03Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
29.03Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
29.03Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
29.03Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
29.03Single7R0CAVP7R0C-V2-AVP-Arrestin2
29.03Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
29.03Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
29.03Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
29.03Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
29.03Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
29.03Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
29.03Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
29.03Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
29.03Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
29.03Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
29.03Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
29.03Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
29.03Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
29.03Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
29.03Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
29.03Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
29.03Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
29.03Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
29.03Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
29.03Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
29.03Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
29.03Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
29.03Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
29.03Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
29.03Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
29.03Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
29.03Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
29.03Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
29.03Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
29.03Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
29.03Consensuslpa_onOrthosteric Ligandlpa1_on
29.03Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
29.03Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
29.03Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
29.03Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
29.03Consensusrelaxin_onOrthosteric Ligandrxfp4_on
29.03Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
29.03Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
29.03Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
29.03Consensustachykinin_offOrthosteric Ligandnk1_off
28.57Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
28.57Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
28.57Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
28.57Single5WS3EMPA5WS3-OX2-EMPA
28.57Single5ZKQABT-4915ZKQ-PAF-ABT-491
28.57Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
28.57Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
28.57Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
28.57Single6TODEMPA6TOD-OX1-EMPA-Na
28.57Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
28.57Single7F8ULintitript7F8U-CCKA-Lintitript
28.57Single7F8YDevazepide7F8Y-CCKA-Devazepide
28.57Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
28.57Single7XRRLemborexant7XRR-OX2-Lemborexant
28.57Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
28.57Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
28.57Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
28.57Single8GNGIstradefylline8GNG-A2A-Istradefylline
28.57Single8IEBA1LYA8IEB-GPR156-A1LYA
28.57Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
28.57Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
28.57Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
28.57Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
28.57Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
28.57Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
28.57Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
28.57Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
28.57Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
28.57Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
28.57Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
28.57Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
28.57Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
28.57Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
28.57Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
28.57Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
28.57Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
28.57Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
28.57Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
28.57Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
28.57Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
28.21Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
28.12Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
28.12Single4AMIBucindolol4AMI-β1-Bucindolol
28.12Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
28.12Single5TZYMK8666; PubChem 1270535975TZY-FFA1-MK8666; PubChem 127053597
28.12Single6A93Risperidone6A93-5-HT2A-Risperidone
28.12Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
28.12Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
28.12Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
28.12Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
28.12Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
28.12Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
28.12Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
28.12Single7K15MKD0467K15-BLT1-MKD046-Na
28.12Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
28.12Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
28.12Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
28.12Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
28.12Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
28.12Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
28.12Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
28.12Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
28.12Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
28.12Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
28.12Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
28.12Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
28.12Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
28.12Consensusalpha1_offOrthosteric Ligandalpha1a_off
28.12Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
28.12Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
28.12Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
28.12Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
28.12Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
28.12Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
28.12Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
28.12Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
28.12Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
28.12Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
28.12Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
28.12Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
28.12Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
28.12Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
27.78Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
27.78Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
27.59Single3REYXAC3REY-A2A-XAC
27.59Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
27.59Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
27.59Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
27.59Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
27.59Single5IU7Q274563465IU7-A2A-Q27456346-Na
27.59Single5JTBZM-2413855JTB-A2A-ZM-241385
27.59Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
27.59Single6AQFZM-2413856AQF-A2A-ZM-241385
27.59Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
27.59Single6MH8ZM-2413856MH8-A2A-ZM-241385
27.59Single6PS0S-Carazolol6PS0-β2-S-Carazolol
27.59Single6PS4ICI118-5516PS4-β2-ICI118-551
27.59Single6PS5S-Propranolol6PS5-β2-S-Propranolol
27.59Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
27.59Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
27.59Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
27.59Single6TPGEMPA6TPG-OX2-EMPA
27.59Single6TPKRetosiban6TPK-OT-Retosiban
27.59Single6TPNHTL66416TPN-OX2-HTL6641
27.59Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
27.59Single6V9SGTPL114036V9S-OX1-GTPL11403
27.59Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
27.59Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
27.59Single7T32ZM-2413857T32-A2A-ZM-241385
27.59Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
27.59Single7UL3Famotidine7UL3-H2-Famotidine
27.59Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.59Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
27.59Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
27.59Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
27.59Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
27.59Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
27.59Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
27.59Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
27.59Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
27.59Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
27.59Single8K9LDamgo8K9L-μ-Damgo-VV9-Gi3/β1/γ1
27.59Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
27.59Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.59Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.59Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
27.59Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
27.59Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
27.59Consensusa2_offOrthosteric Liganda2a_off
27.59Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
27.59Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
27.59Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
27.59Consensusvasop-oxy_offOrthosteric Ligandot_off
27.50Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
27.27Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
27.27Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
27.27Single5X93K-87945X93-ETB-K-8794
27.27Single6H7LDobutamine6H7L-β1-Dobutamine
27.27Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
27.27Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
27.27Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
27.27Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
27.27Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
27.27Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
27.27Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
27.27Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(CtGi1-G13)/β1/γ2
27.27Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
27.27Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
27.27Consensusendothelin_offOrthosteric Ligandetb_off
27.27Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
27.27Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
27.27Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
27.27Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
27.03Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
27.03Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
27.03Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
27.03Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
26.83Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
26.83Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
26.67Single2Y02Carmoterol2Y02-β1-Carmoterol
26.67Single2Y04Salbutamol2Y04-β1-Salbutamol
26.67Single3EMLZM-2413853EML-A2A-ZM-241385
26.67Single3NY8ICI118-5513NY8-β2-ICI118-551
26.67Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
26.67Single4GBRS-Carazolol4GBR-β2-S-Carazolol
26.67Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
26.67Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
26.67Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
26.67Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
26.67Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
26.67Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
26.67Single6PS1Timolol6PS1-β2-Timolol
26.67Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
26.67Single6S0LZM-2413856S0L-A2A-ZM-241385
26.67Single6TOTLemborexant6TOT-OX1-Lemborexant
26.67Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
26.67Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
26.67Single7BU7BI1671077BU7-β1-BI167107
26.67Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
26.67Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
26.67Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
26.67Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
26.67Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
26.67Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
26.67Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
26.67Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
26.67Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
26.67Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
26.67Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
26.67Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
26.67Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
26.67Single8CU6LJ-45178CU6-A2A-LJ-4517
26.67Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
26.67Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
26.67Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
26.67Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
26.67Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
26.67Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
26.67Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
26.67Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.67Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.67Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.67Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.67Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.67Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.67Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.67Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.67Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.67Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.67Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
26.67Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
26.67Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
26.67Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
26.67Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
26.67Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
26.67Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
26.67Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
26.67Single8K5DGSK2560738K5D-HCA2-GSK256073
26.67Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
26.67Single8PJKST1718PJK-5-HT1A-ST171-t7m-Gi1/β1/γ1
26.67Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
26.67Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
26.67Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.67Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.67Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.67Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.67Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
26.67Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
26.67Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
26.67Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
26.67Consensus5ht5_onOrthosteric Ligand5ht5a_on
26.67Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
26.67Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
26.67Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
26.67Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
26.67Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
26.67Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
26.67Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
26.67Consensusblt_onOrthosteric Ligandblt1_on
26.67Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
26.67Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
26.67Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
26.67Consensusdopamine_offOrthosteric Ligandd2_off d3_off
26.67Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
26.67Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
26.67Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
26.67Consensusleukotriene_onOrthosteric Ligandblt_on
26.67Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
26.67Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
26.67Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
26.67Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
26.47Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
26.47Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
26.47Single8X5YAstemizole8X5Y-H1-Astemizole
26.47Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
26.47Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
26.47Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
26.47Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
26.32Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
26.32Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
26.32Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
26.32Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
25.93Single6ME5Agomelatine6ME5-MT1-Agomelatine
25.93Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.93Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
25.93Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
25.81Single2RH1S-Carazolol2RH1-β2-S-Carazolol
25.81Single2Y03Isoprenaline2Y03-β1-Isoprenaline
25.81Single2YCWS-Carazolol2YCW-β1-S-Carazolol
25.81Single5D6LS-Carazolol5D6L-β2-S-Carazolol
25.81Single5JQHS-Carazolol5JQH-β2-S-Carazolol
25.81Single5TVNLSD5TVN-5-HT2B-LSD
25.81Single5XPRBosentan5XPR-ETB-Bosentan
25.81Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
25.81Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
25.81Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
25.81Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
25.81Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
25.81Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
25.81Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
25.81Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
25.81Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
25.81Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
25.81Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
25.81Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
25.81Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
25.81Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
25.81Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
25.81Single7WC6LSD7WC6-5-HT2A-LSD
25.81Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
25.81Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.81Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.81Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
25.81Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
25.81Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
25.81Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
25.81Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
25.81Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
25.81Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
25.81Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
25.81Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
25.81Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
25.81Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
25.81Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
25.81Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
25.81Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
25.81Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
25.81Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
25.81Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
25.81Consensusamine_offonOrthosteric Ligandamine_off amine_on
25.81Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
25.81Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
25.81Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
25.81Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
25.81Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
25.81Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
25.81Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
25.81Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
25.81Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
25.81Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
25.81Consensustrace-amine_onOrthosteric Ligandta1_on
25.71Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
25.71Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
25.71Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
25.71Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
25.71Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
25.71Single8IEPA1LYA8IEP-GPR156-A1LYA
25.71Single8IEPA1LYA8IEP-GPR156-A1LYA
25.71Single8PKMBefiradol8PKM-5-HT1A-Befiradol-t7m-Gi1/β1/γ1
25.71Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
25.71Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
25.64Single6FJ3PTH6FJ3-PTH1-PTH
25.64Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
25.64Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
25.64Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
25.00Single3OE9IT1t3OE9-CXCR4-IT1t
25.00Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
25.00Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
25.00Single5D5AS-Carazolol5D5A-β2-S-Carazolol
25.00Single5D5BS-Carazolol5D5B-β2-S-Carazolol
25.00Single5TZRMK86665TZR-FFA1-MK8666
25.00Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
25.00Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
25.00Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
25.00Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
25.00Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
25.00Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
25.00Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
25.00Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
25.00Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
25.00Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
25.00Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
25.00Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
25.00Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
25.00Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
25.00Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
25.00Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
25.00Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
25.00Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
25.00Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
25.00Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
25.00Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
25.00Single8K5BNiacin8K5B-HCA2-Niacin
25.00Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
25.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
25.00Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
25.00Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
25.00Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
25.00Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
25.00Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
25.00Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
25.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
25.00Single9GE2ML1849GE2-GPR55-ML184-Cholesterol-chim(CtGi1-G13)/β1/γ2
25.00Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
25.00Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
25.00Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
25.00Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
25.00Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
25.00Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
25.00Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
25.00Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
25.00Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
25.00Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
25.00Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
25.00Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
24.39Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
24.39Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
24.39Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
24.32Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
24.24Single3D4STimolol3D4S-β2-Timolol
24.24Single4PY02MeSATP4PY0-P2Y12-2MeSATP
24.24Single4XEENeurotensin4XEE-NTS1-Neurotensin
24.24Single4XESNeurotensin4XES-NTS1-Neurotensin
24.24Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
24.24Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
24.24Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
24.24Single6OS2TRV0266OS2-AT1-TRV026
24.24Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
24.24Single7DFPSpiperone7DFP-D2-Spiperone
24.24Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
24.24Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
24.24Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
24.24Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
24.24Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
24.24Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
24.24Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
24.24Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
24.24Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
24.24Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
24.24Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
24.24Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
24.24Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
24.24Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
24.24Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
24.24Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
24.24Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
24.14Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
24.14Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
24.14Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
24.14Single4S0VSuvorexant4S0V-OX2-Suvorexant
24.14Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
24.14Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
24.14Single6B73MP11046B73-κ-MP1104
24.14Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
24.14Single6DS0Ly2660976DS0-5-HT2B-Ly266097
24.14Single6ME2Ramelteon6ME2-MT1-Ramelteon
24.14Single6ME9Ramelteon6ME9-MT2-Ramelteon
24.14Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
24.14Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
24.14Single6TPJSuvorexant6TPJ-OX2-Suvorexant
24.14Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
24.14Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
24.14Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
24.14Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
24.14Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
24.14Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
24.14Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
24.14Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
24.14Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
24.14Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
24.14Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
24.14Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
24.14Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
24.14Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
24.14Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
24.14Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
24.14Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
24.14Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
24.14Single8IWESpermidine8IWE-TA9-Spermidine
24.14Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
24.14Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
24.14Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
24.14Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
24.14Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
24.14Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
24.14Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
24.14Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
24.14Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
24.14Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
24.14Consensusalpha2_offOrthosteric Ligandalpha2c_off
24.14Consensusangiotensin_offOrthosteric Ligandat1_off
24.14Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
24.14Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
23.68Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
23.68Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
23.68Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
23.53Single4BUONeurotensin4BUO-NTS1-Neurotensin
23.53Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
23.53Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
23.53Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
23.53Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
23.53Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
23.53Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
23.53Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
23.53Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.53Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-PubChem 118610427-chim(NtGi1-Go)/β1/γ2
23.53Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
23.53Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
23.53Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
23.53Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
23.53Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
23.53Single8XVUCXCL28XVU-CXCR2-CXCL2
23.53Single8XWFCXCL38XWF-CXCR2-CXCL3
23.53Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
23.53Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
23.53Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
23.53Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
23.40Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
23.33Single2YDOAdenosine2YDO-A2A-Adenosine
23.33Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
23.33Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
23.33Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
23.33Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
23.33Single5UVIZM-2413855UVI-A2A-ZM-241385
23.33Single6KUXRS-799486KUX-α2a-RS-79948
23.33Single6TP3Nemorexant6TP3-OX1-Nemorexant
23.33Single6VI4JDTic6VI4-κ-JDTic
23.33Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
23.33Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
23.33Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
23.33Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
23.33Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
23.33Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
23.33Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
23.33Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
23.33Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
23.33Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.33Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
23.33Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
23.33Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
23.33Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
23.33Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
23.33Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
23.33Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
23.33Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
23.33Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
23.33Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
23.33Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
23.33Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.33Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.33Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
23.33Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
23.33Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
23.33Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
23.33Single8IHKAcifran8IHK-HCA3-Acifran
23.33Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
23.33Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
23.33Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.33Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.33Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.33Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
23.33Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
23.33Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
23.33Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
23.33Single8ZPMAMD0708ZPM-CXCR4-AMD070-Cholesterol
23.33Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
23.33Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
23.33Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Cholesterol-Gi1/β1/γ2
23.33Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
23.33Consensusalpha1_onOrthosteric Ligandalpha1a_on
23.33Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
23.33Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
23.33Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
23.33Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
23.33Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
23.33Consensusgrh_offOrthosteric Ligandgnrh1_off
23.33Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
23.26Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
23.26Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
23.08Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
23.08Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
22.86Single5EE7MK08935EE7-Glucagon-MK0893
22.86Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
22.86Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
22.86Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
22.86Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
22.86Single8IEIA1LYA8IEI-GPR156-A1LYA
22.86Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
22.86Single8XQJJN2418XQJ-Apelin-JN241
22.86Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
22.86Consensuskisspeptin_onOrthosteric Ligandkiss1_on
22.58Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
22.58Single2Y01Dobutamine2Y01-β1-Dobutamine
22.58Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
22.58Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
22.58Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
22.58Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
22.58Single4QIMANTA XV4QIM-SMO-ANTA XV
22.58Single4QKX35V4QKX-β2-35V
22.58Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
22.58Single6D27CAY104716D27-DP2-CAY10471
22.58Single6DRXLisuride6DRX-5-HT2B-Lisuride
22.58Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
22.58Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
22.58Single6GPSMK08126GPS-CCR2-MK0812
22.58Single6H7MSalbutamol6H7M-β1-Salbutamol
22.58Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
22.58Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
22.58Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
22.58Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
22.58Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
22.58Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
22.58Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
22.58Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
22.58Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
22.58Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
22.58Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
22.58Single7WC7Lisuride7WC7-5-HT2A-Lisuride
22.58Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
22.58Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
22.58Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
22.58Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
22.58Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
22.58Single8JJOAlprenolol8JJO-β2-Alprenolol
22.58Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
22.58Single8JXRLSD8JXR-D1-LSD
22.58Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
22.58Single8T1WCVN4248T1W-GPR6-CVN424
22.58Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
22.58Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
22.58Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
22.58Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
22.58Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
22.58Single9IYAONO-97105319IYA-GPR55-ONO-9710531
22.58Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
22.58Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
22.58Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
22.58Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
22.58Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
22.58Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
22.58Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
22.58Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
22.50Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
22.50Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
22.50Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
22.50Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
22.50Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
22.22Single3RFMCaffeine3RFM-A2A-Caffeine
22.22Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
22.22Single8A2OTheophylline8A2O-A2A-Theophylline-Na
22.22Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.22Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
22.22Single8IEIA1LYA8IEI-GPR156-A1LYA
22.22Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
22.22Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
22.22Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
22.22Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
22.22Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
22.22Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
21.95Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
21.95Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
21.95Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
21.88Single2Y00Dobutamine2Y00-β1-Dobutamine
21.88Single4NTJAZD12834NTJ-P2Y12-AZD1283
21.88Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
21.88Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
21.88Single5WIUNemonapride5WIU-D4-Nemonapride
21.88Single5WIVNemonapride5WIV-D4-Nemonapride-Na
21.88Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
21.88Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
21.88Single6GPXMK08126GPX-CCR2-MK0812
21.88Single6HLPNetupitant6HLP-NK1-Netupitant
21.88Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
21.88Single6PS6Timolol6PS6-β2-Timolol
21.88Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
21.88Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
21.88Single7C4SS1P7C4S-S1P3-S1P
21.88Single7SINNPS-21437SIN-CaS-NPS-2143
21.88Single7SINNPS-21437SIN-CaS-NPS-2143
21.88Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
21.88Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
21.88Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
21.88Single8ZMFA1L108ZMF-5-HT2C-A1L10
21.88Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
21.88Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
21.88Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
21.88Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
21.88Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
21.88Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
21.88Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
21.88Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
21.88Consensusblt_offOrthosteric Ligandblt1_off
21.88Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
21.88Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
21.88Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
21.88Consensusep_offOrthosteric Ligandep4_off
21.88Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
21.88Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
21.62Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
21.43Single3OE6IT1t3OE6-CXCR4-IT1t
21.43Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
21.43Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
21.43Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
21.43Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
21.43Single7V6A-7V6A-M4-PubChem 9864275-Gi1/β1/γ2
21.43Single7WC5Psilocin7WC5-5-HT2A-Psilocin
21.43Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
21.43Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.43Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
21.43Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
21.43Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
21.43Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
21.43Consensus5ht2_onOrthosteric Ligand5ht2b_on
21.43Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.43Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
21.43Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
21.21Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
21.21Single4BV0Neurotensin4BV0-NTS1-Neurotensin
21.21Single5V54Methiothepin5V54-5-HT1B-Methiothepin
21.21Single5V56TC1145V56-SMO-TC114
21.21Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
21.21Single6OS1TRV0266OS1-AT1-TRV026
21.21Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
21.21Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
21.21Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
21.21Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
21.21Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
21.21Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.21Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
21.21Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
21.21Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
21.21Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
21.21Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
21.21Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
21.21Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
21.21Single8XVLZibotentan8XVL-ETA-Zibotentan
21.21Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
21.21Single9F33FOB02-04A9F33-D3-FOB02-04A-Go1/β1/γ2
21.21Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
21.21Consensus5ht1_offOrthosteric Ligand5ht1b_off
21.21Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
21.21Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
21.21Consensusneurotensin_onOrthosteric Ligandnts1_on
21.21Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
21.21Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
21.21Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
20.69Single3PBLEticlopride3PBL-D3-Eticlopride
20.69Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
20.69Single6TP4ACT-4622066TP4-OX1-ACT-462206
20.69Single7SRQLSD7SRQ-5-HT2B-LSD
20.69Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
20.69Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
20.69Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
20.69Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
20.69Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
20.69Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
20.69Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
20.69Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
20.69Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
20.69Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
20.69Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
20.69Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
20.69Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
20.69Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
20.59Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
20.59Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
20.59Single4N4WSANT-14N4W-SMO-SANT-1
20.59Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
20.59Single6CM4Risperidone6CM4-D2-Risperidone
20.59Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
20.59Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
20.59Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
20.59Single6YVRNTS8-136YVR-NTS1-NTS8-13
20.59Single6ZG4HTL00099366ZG4-M1-HTL0009936
20.59Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
20.59Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
20.59Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.59Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
20.59Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
20.59Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
20.59Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
20.59Single8XWACXCL18XWA-CXCR2-CXCL1
20.59Single8XWMCXCL68XWM-CXCR2-CXCL6
20.59Single8XWSCXCL58XWS-CXCR2-CXCL5
20.59Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
20.59Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
20.59Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
20.59Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
20.59Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
20.51Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
20.51Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
20.51Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ22
20.45Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
20.45Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
20.00Single3ODUIT1t3ODU-CXCR4-IT1t
20.00Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
20.00Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
20.00Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
20.00Single6K1QIRL25006K1Q-ETB-IRL2500
20.00Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
20.00Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
20.00Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
20.00Single7BR3Elagolix7BR3-GnRH1-Elagolix
20.00Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
20.00Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
20.00Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
20.00Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
20.00Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
20.00Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
20.00Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
20.00Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
20.00Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
20.00Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
20.00Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
20.00Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
20.00Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
20.00Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
20.00Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/β1/γ2
20.00Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
20.00Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
20.00Single8Y0HVUF114188Y0H-CXCR3-VUF11418
20.00Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
20.00Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
20.00Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
20.00Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
20.00Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
20.00Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
20.00Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
20.00Consensusfp-alpha_onOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
19.51Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
19.51Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
19.51Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
19.51Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
19.44Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
19.44Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
19.35Single6A94Zotepine6A94-5-HT2A-Zotepine
19.35Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
19.35Single6IQLL7458706IQL-D4-L745870
19.35Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
19.35Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
19.35Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
19.35Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
19.35Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
19.35Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
19.35Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
19.35Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
19.35Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
19.35Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
19.35Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
19.35Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
19.35Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
19.35Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
19.35Single8K2WAMG4878K2W-CXCR3-AMG487
19.35Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
19.35Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
19.35Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
19.35Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
19.35Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
19.35Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
19.35Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
19.35Single8ZPNAMD31008ZPN-CXCR4-AMD3100-Cholesterol
19.35Single9BJKNaloxone9BJK-μ-Naloxone-NAM
19.35Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
19.35Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
19.35Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
19.35Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
19.35Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
19.35Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
19.35Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
19.35Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
19.05Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
19.05Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
19.05Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
19.05Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
18.92Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
18.92Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
18.92Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
18.92Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
18.75Single5DHGC-355DHG-NOP-C-35
18.75Single5DHHSB-6121115DHH-NOP-SB-612111
18.75Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
18.75Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
18.75Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/β1/γ2
18.75Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
18.75Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
18.75Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
18.75Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
18.75Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
18.75Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
18.75Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
18.75Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
18.75Single8X63Mepyramine8X63-H1-Mepyramine
18.75Single8X64Desloratadine8X64-H1-Desloratadine
18.75Consensusalpha2_onOrthosteric Ligandalpha2b_on
18.75Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
18.75Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
18.75Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
18.75Consensushistamine_offOrthosteric Ligandh1_off
18.60Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
18.60Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
18.60Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
18.60Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
18.60Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
18.60Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
18.52Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
18.52Single8PWNTheophylline8PWN-A2A-Theophylline
18.42Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
18.42Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
18.18Single4JKVTaladegib4JKV-SMO-Taladegib
18.18Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
18.18Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
18.18Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
18.18Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
18.18Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
18.18Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
18.18Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
18.18Single9F34FOB02-04A9F34-D3-FOB02-04A-Go1/β1/γ2
18.18Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
17.95Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
17.86Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
17.86Single6TQ9SB-4081246TQ9-OX1-SB-408124
17.86Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.86Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
17.86Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
17.86Single9CHUNoradrenaline9CHU-β2-Noradrenaline
17.86Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
17.86Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
17.65Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
17.65Single4U15Tiotropium4U15-M3-Tiotropium
17.65Single5V57TC1145V57-SMO-TC114
17.65Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
17.65Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
17.65Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
17.65Single6OL9Tiotropium6OL9-M5-Tiotropium
17.65Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
17.65Single7F1TMIP-1a7F1T-CCR5-MIP-1a
17.65Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
17.65Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
17.65Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
17.65Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
17.65Single9BJKNAM9BJK-μ-Naloxone-NAM
17.65Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
17.65Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
17.65Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
17.65Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
17.50Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
17.50Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
17.50Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
17.39Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
17.39Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
17.24Single3UZAGTPL92363UZA-A2A-GTPL9236
17.24Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
17.24Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
17.24Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
17.24Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
17.24Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
17.24Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
17.24Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
17.24Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
17.24Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
17.24Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
17.24Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
17.24Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
17.24Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
17.24Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
17.24Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
17.24Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
17.14Single5CXVTiotropium5CXV-M1-Tiotropium
17.14Single5X33BIIL2605X33-BLT1-BIIL260
17.14Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
17.14Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
17.14Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.14Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
17.14Single8XQJJN2418XQJ-Apelin-JN241
17.14Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
17.14Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
16.67Single5L7IVismodegib5L7I-SMO-Vismodegib
16.67Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
16.67Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
16.67Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
16.67Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
16.67Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
16.67Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
16.67Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
16.67Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
16.67Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single8XVJMacitentan8XVJ-ETA-Macitentan
16.67Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go1/β1/γ2
16.67Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
16.67Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
16.67Single8YN7Immethridine8YN7-H3-Immethridine-Go1/β1/γ2
16.67Single8YRGFospropofol8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
16.67Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
16.67Consensusgq_nucleotideOrthosteric Ligandgq_p2y
16.67Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
16.28Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
16.28Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
16.28Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
16.28Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
16.22Single6KNMJN241-96KNM-Apelin-JN241-9
16.22Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
16.22Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
16.22Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
16.13Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
16.13Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
16.13Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
16.13Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
16.13Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
16.13Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
16.13Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
16.13Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
16.13Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
16.13Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
16.13Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
16.13Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
16.13Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
16.13Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
16.13Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
16.13Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
16.13Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
16.13Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
16.13Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
16.13Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
16.13Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.13Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
16.13Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
16.13Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
16.13Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ
16.13Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
16.13Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
16.13Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
16.13Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
16.13Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
16.13Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
16.13Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
16.13Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
16.13Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
16.13Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
16.13Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
15.91Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
15.91Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
15.79Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
15.62Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
15.62Single3RZECidoxepin3RZE-H1-Cidoxepin
15.62Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
15.62Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
15.62Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
15.62Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
15.62Single6ZG9GSK10347026ZG9-M1-GSK1034702
15.62Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
15.62Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
15.62Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
15.62Single7VV6C48/807VV6-MRGPRX2-C48/80
15.62Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.62Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
15.62Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
15.62Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
15.62Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.62Single8YN8Proxyfan8YN8-H3-Proxyfan-Go1/β1/γ2
15.62Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
15.62Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
15.62Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
15.62Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
15.56Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/β1/γ2
15.56Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
15.38Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
15.22Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
15.15Single4DAJTiotropium4DAJ-M3-Tiotropium
15.15Single4MQSIperoxo4MQS-M2-Iperoxo
15.15Single4U14Tiotropium4U14-M3-Tiotropium
15.15Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
15.15Single5T04Neurotensin5T04-NTS1-Neurotensin
15.15Single5TGZAM65385TGZ-CB1-AM6538
15.15Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
15.15Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
15.15Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
15.15Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
15.15Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.15Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
15.15Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
15.15Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
15.15Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
15.15Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
15.15Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
15.15Single7YXAONO-54306087YXA-S1P5-ONO-5430608
15.15Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
15.15Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
15.15Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
15.15Single9B9ZA1AKO9B9Z-CB1-A1AKO
15.15Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
15.15Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
15.15Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
15.15Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
14.81Single5MZPCaffeine5MZP-A2A-Caffeine-Na
14.81Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
14.81Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
14.71Single6LUQHaloperidol6LUQ-D2-Haloperidol
14.71Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
14.71Single6Z4SSR486926Z4S-NTS1-SR48692
14.71Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
14.71Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
14.71Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
14.71Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.71Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
14.71Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
14.71Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
14.71Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
14.71Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
14.71Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
14.71Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
14.71Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
14.71Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.71Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.63Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
14.58Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
14.29Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
14.29Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
14.29Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
14.29Single7WC4Serotonin7WC4-5-HT2A-Serotonin
14.29Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
14.29Single8EA0Iperoxo8EA0-M3-Iperoxo
14.29Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
14.29Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
14.29Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
13.95Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
13.89Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
13.89Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
13.89Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
13.89Single8XJNCloprosetnol8XJN-TP-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
13.89Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
13.79Single3OE8IT1t3OE8-CXCR4-IT1t
13.79Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
13.79Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
13.79Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
13.79Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
13.79Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
13.79Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
13.79Consensussensory_onOrthosteric Ligandopsins_on
13.64Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
13.51Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
13.51Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
13.51Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
13.51Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
13.51Consensustp_onOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
13.51Consensustp_on_gpOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
13.46Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
13.33Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
13.33Single4XNWMRS25004XNW-P2Y1-MRS2500
13.33Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
13.33Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
13.33Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
13.33Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
13.33Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
13.33Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
13.33Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.33Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
13.33Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
13.33Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
13.33Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
13.33Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
13.33Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
13.33Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
13.33Consensusgi_sensoryOrthosteric Ligandgi_opsins
13.33Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
13.33Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
13.33Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
13.33Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
13.33Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
13.33Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
13.21Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
13.16Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
12.90Single4O9RCyclopamine4O9R-SMO-Cyclopamine
12.90Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
12.90Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
12.90Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
12.90Single6LI0C176LI0-GPR52-C17
12.90Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
12.90Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
12.90Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
12.90Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
12.90Single7UL2SR486927UL2-NTS1-SR48692-Na
12.90Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
12.90Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
12.90Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
12.90Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
12.90Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
12.90Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
12.90Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.90Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
12.90Single9B9Y7DY9B9Y-CB1-7DY
12.90Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
12.90Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
12.90Consensusneurotensin_offOrthosteric Ligandnts1_off
12.90Consensusnts1_offOrthosteric Ligand7UL2-NTS1-SR48692-Na
12.82Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
12.77Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
12.77Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
12.50Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
12.50Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
12.50Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
12.50Single4BWBNeurotensin4BWB-NTS1-Neurotensin
12.50Single4QINSAG1.54QIN-SMO-SAG1.5
12.50Single5U09Taranabant5U09-CB1-Taranabant
12.50Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
12.50Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
12.50Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
12.50Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
12.50Single9BA0A1AKN9BA0-CB1-A1AKN
12.24Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
12.24Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
12.24Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
12.12Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
12.12Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
12.12Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
12.12Single6ZINSR486926ZIN-NTS1-SR48692
12.12Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
12.12Single7VODCariprazine7VOD-5-HT2A-Cariprazine
12.12Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
12.12Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
12.12Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
12.12Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
12.12Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
12.12Consensusopsins_offOrthosteric Ligandrhodopsin_off
12.12Consensussensory_offOrthosteric Ligandopsins_off
11.90Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
11.76Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
11.76Single5DSGTiotropium5DSG-M4-Tiotropium
11.76Single7F83PF-051904577F83-Ghrelin-PF-05190457
11.76Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
11.76Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
11.76Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
11.43Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
11.43Single5CGCHTL142425CGC-mGlu5-HTL14242
11.43Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
11.43Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
11.43Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
11.43Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
11.43Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
11.43Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
11.11Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
11.11Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
11.11Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
11.11Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
10.87Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
10.81Single6IIURamatroban6IIU-TP-Ramatroban
10.81Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
10.71Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
10.71Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
10.53Single5CGDHTL142425CGD-mGlu5-HTL14242
10.53Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
10.34Single3PXOAll-trans-Retinal3PXO-Rhodopsin-All-trans-Retinal
10.34Single5DYSAll-trans-Retinal5DYS-Rhodopsin-All-trans-Retinal
10.34Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
10.34Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
10.26Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
10.00Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
10.00Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
10.00Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
10.00Consensusp2y_offOrthosteric Ligandp2y1_off
9.76Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
9.68Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
9.68Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
9.68Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
9.68Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
9.68Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
9.38Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
9.38Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
9.38Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
9.38Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
9.38Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
9.38Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
9.30Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
9.09Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
9.09Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
9.09Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
9.09Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
9.09Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
9.09Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
9.09Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
9.09Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
9.09Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
9.09Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
9.09Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
9.09Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
9.09Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
9.09Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
8.82Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
8.70Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
8.57Single6IIVDaltroban6IIV-TP-Daltroban
8.57Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
8.33Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
8.33Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
8.33Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
8.33Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
8.11Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
8.11Single7P2L4YI7P2L-mGlu5-4YI
8.11Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
8.11Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Cholesterol-Gi1/β1/γ1
7.69Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
6.90Single4A4MAll-trans-Retinal4A4M-Rhodopsin-All-trans-Retinal-Gt(CT)
6.90Single5EN0All-trans-Retinal5EN0-Rhodopsin-All-trans-Retinal-Gt(CT)
6.67Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
6.67Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
6.67Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
6.67Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
6.45Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
6.45Single7Y14Beta-Alanine7Y14-MRGPRD-β-Alanine
6.45Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/β1/γ2
6.25Single7Y12Beta-Alanine7Y12-MRGPRD-β-Alanine-Gi1/β1/γ2
6.25Single8JPSCCL78JPS-ACKR1-CCL7
6.25Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
6.06Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
6.06Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
5.88Single7VVOPTH7VVO-PTH1-PTH-Gs/β1/γ2
5.71Single6FFIMMPEP6FFI-mGlu5-MMPEP
5.56Single6FFHFenobam6FFH-mGlu5-Fenobam
5.41Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
5.26Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
4.65Single7SHEPI; PE7SHE-GPR158-PI; PE
3.45Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
3.33Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/β1/γ2
3.23Single9GE2Cholesterol9GE2-GPR55-ML184-Cholesterol-chim(CtGi1-G13)/β1/γ2
3.12Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
3.12Single8IKGQ2B8IKG-CB1-Q2B-Gi1/β1/γ1
3.03Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
3.03Single7F61Cholesterol7F61-H3-PF-03654746-Cholesterol
3.03Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
2.94Single7FEEZCZ0117FEE-CB1-CP55940-ZCZ011
2.94Single8HSCFab0468HSC-GPR20-Fab046-Gi1/β1/γ2
2.94Single8IKHQ2L8IKH-CB1-Q2L-Gi1/β1/γ1
2.94Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
2.94Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
2.94Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
2.86Single4XNVBPTU4XNV-P2Y1-BPTU
2.86Single7WV9ZCZ0117WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
2.86Single8G94CD698G94-S1P1-CD69-Gi1/β1/γ2
2.78Single8IYXYL-3658IYX-GPR34-YL-365
2.63Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
2.63Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
2.56Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
2.50Single7SHEPI; PE7SHE-GPR158-PI; PE
2.44Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
2.27Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7

Consensus Members
Id Members
gs_cck 7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
gs_melanocortin 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
7F54-MC4-Afamelanotide-Gs/β1/γ2
7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
7F53-MC4-α-MSH-Gs/β1/γ2
7F55-MC4-Bremelanotide-Gs/β1/γ2
8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
7F58-MC4-THIQ-Gs/β1/γ2
gs_vasop-oxy 7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
Net Summary
Imin 3.04
Number of Linked Nodes 936
Number of Links 1138
Number of Hubs 185
Number of Links mediated by Hubs 702
Number of Communities 26
Number of Nodes involved in Communities 256
Number of Links involved in Communities 379
Path Summary
Number Of Nodes in MetaPath 94
Number Of Links MetaPath 93
Number of Shortest Paths 3018338
Length Of Smallest Path 3
Average Path Length 34.9758
Length of Longest Path 67
Minimum Path Strength 0.0940278
Average Path Strength 6.12406
Maximum Path Strength 20.4247
Minimum Path Correlation 0.701667
Average Path Correlation 0.978175
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.69492
Average % Of Corr. Nodes 34.0912
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 48.4181
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following consensuses:
IdComponents
gs_class-ags_peptide
gs_nucleotide
gs_amine



You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download gs_peptide.zip



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