Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
1G.S1.02 4.63125475
2G.S1.06 4.725408
3G.S2.06 7.9625409
4G.S2.08 7.285575
5G.S3.03 6.19833677
6G.S3.06 9.58125415
7G.s3h2.03 4.4125419
8G.H2.06 8.151519
9G.H2.07 5.38714719
10G.h2s4.01 6.05643719
11G.S4.03 4.598754157
12G.S4.06 5.0725407
13G.s4h3.04 7.0245108
14G.H3.01 8.518754179
15G.H3.09 7.47071749
16G.H3.17 7.04505
17G.H3.18 5.823754169
18G.S5.03 4.241254158
19G.S5.04 4.62125449
20G.S5.05 4.668336159
21G.S5.06 5.89375408
22G.S5.07 3.51625409
23G.HG.07 8.251254109
24G.hgh4.02 5.81083647
25G.hgh4.05 7.981507
26G.H4.05 4.83754194
27G.H4.10 9.70375446
28G.H4.15 5.767548
29G.h4s6.10 3.64875403
30G.S6.02 8.077567
31G.s6h5.01 5.0125409
32G.s6h5.02 3.3825187
33G.H5.08 6.432578
34G.H5.13 8.38468
35G.H5.23 3.67125404
36G.H5.25 3.9725407
37b.1x11 1.0525408
38b.lh12x2 3.21625408
39b.lhb1x3 2.975682
40b.lhb1x6 4.995483
41b.b1x6 7.7075459
42b.l1x3 7.53714759
43b.b2x1 7.007518
44b.b2x5 5.54607
45b.b3x4 5.7025459
46b.l3x2 4.17167659
47b.b4x4 7.362558
48b.b4x6 8.99571759
49b.l4x2 8.2225404
50b.b5x2 7.20875407
51b.b5x3 6.147559
52b.b5x7 7.23125407
53b.l5x1 4.3175408
54b.l5x5 7.00571719
55b.b6x5 3.96833606
56b.l6x5 6.0965114
57b.b7x1 6.3175114
58b.l7x2 4.592519
59b.b8x4 5.408506
60b.l8x5 4.96125403
61b.b9x2 2.885405
62b.l9x3 5.5619
63b.l9x6 5.52125818
64b.l9x7 3.62625417
65b.b10x3 4.06125408
66b.b10x5 4.499509
67b.l10x4 3.998754213
68b.b11x4 3.835419
69b.b11x6 4.8975419
70b.l11x2 5.8419
71b.b12x6 11.3325418
72b.b13x3 6.92625414
73b.b13x7 7.506537
74b.l13x3 6.4575639
75b.l13x6 5.30875419
76b.b14x1 5.8518
77b.b14x3 5.98625435
78b.b14x5 4.162535
79b.b15x1 6.124539
80b.l15x1 3.778517
81b.l15x2 4.84875439
82b.b16x4 10.415436
83b.b16x5 4.64875415
84b.b16x6 8.19167638
85b.b17x4 4.142515
86b.b17x5 6.7417
87b.b17x7 7.23375418
88b.l17x3 7.88583619
89b.l17x6 7.291519
90b.b18x3 4.63875418
91b.b18x5 5.7675405
92b.l18x1 5.7258126
93b.l18x3 5.87254125
94b.b19x2 6.2775616
95b.b19x4 4.654518
96b.b19x6 6.58419
97b.l19x1 6.1325419
98b.l19x2 5.677519
99b.b20x2 6.0225416
100b.b20x4 13.774518
101b.b20x6 7.792516
102b.l20x2 6.7575409
103b.l20x3 1.795407
104b.b21x1 6.485417
105b.b21x3 7.96375416
106b.b21x7 5.68917605
107b.b22x5 6.931254127
108b.l22x5 5.57789
109b.b23x6 7.385836137
110b.l23x1 9.12416
111b.b24x4 8.664136
112b.b24x6 7.681254138
113b.l24x2 5.18625406
114b.l24x3 6.0125485
115b.l25x3 10.5662499
116b.l25x6 13.0613418
117b.l26x5 4.07625405
118b.l27x1 12.6867619
119b.l27x2 8.035499
120b.b28x3 5.0375457
121b.b28x4 5.366596
122b.b28x6 11.0588499
123g.ctx3 4.2875409
124g.ctx9 3.7525606
125Lig 11.181620
126NT 9.746251223
1271x39 3.674507
1281x50 4.7625409
129I1 3.41405
1302x38 6.53375407
1312x42 6.553508
1322x50 5.8125409
1332x57 4.87625408
1342x60 5.45417626
1352x63 4.93425
1362x64 5.54424
137E1x50 8.052528
1383x28 6.2475426
1393x29 6.642524
1403x30 4.098506
1413x32 5.57527
1423x37 10.11254247
143I2x51 3.64357707
1444x39 6.728754223
1454x50 4.1165239
1464x59 2.585405
147E2 21.88181123
1485x47 3.765408
1495x58 4.625409
150I3 9.81286765
1516x26 5.12875464
1526x37 4.31875408
1536x38 2.1925405
1546x44 5.39125409
1556x48 6.375508
1566x51 7.9575426
1576x54 7.80417625
1586x55 6.88667626
159E3 14.0175622
1607x30 7.917524
1617x31 11.2937424
1627x33 3.224524
1637x34 8.701524
1647x42 5.603507
1658x50 4.86254148
1668x54 6.19756147
167H.HA.14 2.69125400
168H.HA.19 2.54254260
169H.HA.20 2.32875400
170H.HA.26 2.42375400
171H.HB.02 3.463754280
172H.hbhc.13 2.3175400
173H.HC.03 2.588500
174H.HC.11 5.041500
175H.HD.07 2.61625400
176H.hdhe.01 3.08125400
177H.HE.04 6.563754290
178H.HE.05 3.625400
179H.hehf.04 5.19625400
180H.HF.03 4.65375400
181g.h3x13 3.33375480
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1b.b1x4 g.ctx9 19.79046.415NoYes076
2g.ctx14 g.ctx9 24.36675.91NoYes096
3b.b28x7 g.ctx14 24.56153.405NoNo099
4b.b28x7 b.lhb1x11 25.1474.21NoNo094
5b.lhb1x11 b.lhb1x9 25.44633.645NoNo043
6b.lhb1x6 b.lhb1x9 25.84513.07YesNo033
7b.l22x5 b.lhb1x6 26.20658.5YesYes893
8b.l22x5 b.l24x2 34.77037.29YesYes096
9b.h2x5 b.l24x2 35.20448.84NoYes056
10b.h2x1 b.h2x5 36.09195.895NoNo055
11b.b21x5 b.h2x1 37.64654.945NoNo045
12b.b21x5 b.b21x7 38.097313.77NoYes045
13b.b21x7 b.b24x6 39.22485.305YesYes058
14b.b23x6 b.b24x6 40.13958.685YesYes1378
15b.b23x6 b.l23x2 42.53164.6YesNo078
16b.l21x7 b.l23x2 43.2363.89NoNo058
17b.l21x7 b.l23x1 43.47163.89NoYes056
18b.l23x1 b.l25x6 43.936123.225YesYes168
19b.l25x6 b.l27x1 39.523719.99YesYes189
20b.b2x1 b.l27x1 40.41296.75YesYes189
21G.H2.10 b.b2x1 34.76384.03NoYes178
22G.S1.05 G.S1.07 84.22193.46NoNo099
23G.S1.07 G.S4.04 84.00453.045NoNo099
24G.H3.09 G.S4.04 83.786818.22YesNo099
25G.H3.09 G.S5.04 70.27165.48YesYes499
26G.S5.04 G.S5.06 70.20213.46YesYes098
27G.S5.06 G.S6.05 67.91846.7YesNo084
28G.H4.07 G.S6.05 67.88164.855NoNo054
29G.H4.03 G.H4.07 67.76663.335NoNo045
30G.H4.03 G.HG.01 67.42124.78NoNo045
31G.HG.01 G.s6h5.05 66.66434.84NoNo1859
32G.s6h5.01 G.s6h5.05 66.61374.335YesNo099
33G.H2.10 G.h2s4.01 24.97115.59NoYes179
34G.S1.05 G.h2s4.01 79.772212.175NoYes099
35G.S6.04 G.s6h5.01 57.99055.48NoYes099
36G.H3.09 G.H4.15 12.02398.575YesYes498
37G.H5.06 I3 54.47985.765NoYes635
38G.H5.06 G.S6.04 54.598714.705NoNo039
39G.H2.07 G.h2s4.01 47.31243.51YesYes199
40G.h2s4.01 b.l7x2 47.13953.045YesYes199
41b.l5x5 b.l7x2 20.27656.26YesYes199
42G.H2.07 b.l9x6 47.28956.27YesYes198
43b.l7x2 b.l9x6 67.46974.1YesYes198
44b.l13x6 b.l9x6 19.34759.195YesYes198
45b.l13x6 b.l15x1 24.10533.11YesYes197
46b.b14x1 b.l9x6 76.84914.79YesYes188
47b.b14x1 b.l15x1 19.1923.24YesYes187
48b.l15x1 b.l17x6 43.15453.89YesYes179
49G.H2.06 b.b14x1 38.356914.4YesYes198
50G.H2.06 b.l17x6 19.142710.37YesYes199
51b.b14x1 b.b18x1 19.22283.505YesNo189
52G.H2.06 b.l19x1 19.17174.145YesYes199
53b.b18x1 b.l19x1 19.15826.06NoYes199
54G.H5.13 I3 52.534711.67YesYes685
556x26 G.H5.13 52.72856.55YesYes648
565x68 G.H5.16 52.40554.375NoNo066
576x26 G.H5.16 52.52665.01YesNo046
586x30 G.H5.20 51.31282.77NoNo079
595x65 6x30 51.79893.46NoNo087
605x65 5x68 51.92032.825NoNo086
61G.H5.20 G.H5.25 51.19115.535NoYes097
622x36 2x38 47.2723.545NoYes077
632x38 3x49 47.64165.645YesNo078
642x42 3x49 47.88777.625YesNo088
652x42 3x46 48.74764.215YesNo089
663x46 3x50 48.98359.11NoNo099
673x50 G.H5.23 49.36036.265NoYes094
68G.H5.23 G.H5.25 49.72745.555YesYes047
69b.l17x5 b.l17x6 62.11888.095NoYes169
70b.l17x5 b.l19x2 1006.625NoYes169
71b.l17x3 b.l19x2 74.09555.67YesYes199
72b.b19x4 b.l17x3 49.41014.11YesYes189
73b.b19x2 b.b19x4 24.4053.24YesYes168
74b.b17x7 b.b19x2 21.9766.43YesYes186
75b.b17x7 b.b21x1 39.35524.18YesYes187
76b.1x19 b.b21x1 35.91384.17NoYes067
77b.1x15 b.1x19 26.85551.88NoNo076
78b.1x15 g.h1x15 25.73651.625NoNo078
79b.1x11 g.h1x15 24.61760.79YesNo088
80b.1x11 g.h1x11 19.02271.385YesNo089
81b.1x12 g.h1x11 17.90372.82NoNo069
82b.1x12 b.1x8 12.30880.805NoNo065
83b.1x8 g.h1x8 11.18980.85NoNo057
84b.l17x5 b.l19x1 38.17843.68NoYes169
85b.b19x4 b.b20x6 22.26419.08YesYes186
86b.b17x7 b.b20x6 65.877510.715YesYes186
87b.b20x4 b.l17x3 23.787716.93YesYes189
88b.b20x4 b.b20x6 44.52244.81YesYes186
89b.b20x2 b.l19x2 24.69873.615YesYes169
90b.b20x2 b.b20x4 23.787814.875YesYes168
91b.b1x6 b.b28x3 15.29936.92YesYes597
92b.b27x4 b.b28x3 16.42853.42NoYes057
93b.b27x4 b.b27x5 15.96082.785NoNo059
94b.b27x5 b.l25x3 10.309616.74NoYes999
95b.b14x5 b.l10x1 11.80258.305YesNo353
96b.b11x1 b.l10x1 11.99373.99NoNo053
97b.b11x1 b.l10x4 12.08543.3NoYes053
98b.l10x4 b.l12x2 12.22813.94YesNo2136
99b.b9x2 b.l12x2 12.82314.07YesNo056
100b.b9x2 b.l12x1 20.62023.135YesNo056
101b.b8x3 b.l12x1 20.7145.89NoNo066
102b.b7x1 b.b8x3 20.90473.025YesNo046
103b.b10x5 b.b7x1 22.43023.61YesYes094
104b.b10x5 b.b11x2 22.82245.02YesNo097
105b.b10x3 b.b11x2 22.92154.09YesNo087
106b.l11x1 b.l9x6 19.04596.52NoYes198
107b.b11x6 b.l11x1 23.97773.71YesNo199
108b.b11x6 b.l9x3 11.93886.975YesYes199
109b.b11x6 b.l9x7 11.70833.755YesYes197
110b.b11x4 b.l9x3 11.6713.425YesYes199
111b.b11x4 b.l9x7 11.60993.685YesYes197
112b.b10x3 b.b11x4 23.22013.38YesYes089
113b.b17x5 b.b17x7 47.27597.61YesYes178
114b.b16x5 b.b17x5 40.05444.655YesYes157
115b.b16x5 b.l20x1 36.38564.845YesNo056
116b.l18x5 b.l20x1 35.1613.435NoNo026
117b.l18x3 b.l18x5 26.00117.495YesNo052
118b.l18x1 b.l18x3 14.49417.855YesYes1265
1192x36 2x40 47.02542.475NoNo078
1201x57 2x40 46.83912.57NoNo078
1211x53 1x57 45.00673.685NoNo097
1221x53 7x50 43.0762.625NoNo099
1231x50 7x50 42.7025.705YesNo099
1241x50 2x50 42.07874.04YesYes099
1252x50 7x46 35.11045.3YesNo099
1262x54 7x46 34.72635.295NoNo079
1272x54 7x42 34.60064.1NoYes077
1282x60 7x42 33.15827.295YesYes067
1292x60 2x64 10.96446.415YesYes264
1302x64 Lig 10.29064.395YesYes240
1312x60 7x34 15.23114.49YesYes264
1327x34 Lig 10.30046.645YesYes240
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
LigNT11.392YesYes0301
7x27Lig15.42NoYes2010
6x58Lig21.172NoYes4010
E3Lig35.62YesYes2010
7x30Lig13.9252YesYes4010
7x31Lig5.9052YesYes4010
E1Lig6.3452NoYes4010
E2Lig13.882YesYes3010
E2x51Lig3.1252NoYes4010
2x64Lig4.3952YesYes4010
7x34Lig6.6452YesYes4010
3x29Lig5.862YesYes4010
4x65Lig4.9452NoYes6010
6x55Lig7.8952YesYes6010
E2NT19.0752YesYes3311
E1NT25.2852NoYes4311
NTNT4.4052YesYes3311
7x27NT3.812NoYes2311
7x31NT19.3752YesYes4311
1x32NT5.2552NoYes5321
7x32NT14.6352NoYes1321
1x317x323.822NoNo3122
2x602x646.4152YesYes6421
2x603x283.932YesYes6622
2x607x344.492YesYes6421
2x607x387.232YesNo6622
2x643x293.612YesYes4411
2x647x347.742YesYes4411
E1E1x4911.442NoNo4512
3x22E23.9852NoYes3321
3x25E23.5452NoYes9321
3x26E232NoYes7321
3x283x325.1452YesYes6722
3x294x6513.172YesNo4611
3x326x516.1752YesYes7622
4x65E2x529.2252NoNo6512
E2E275.052YesYes3311
E2E2x5115.942YesNo3411
E2x51E2x524.3752NoNo4512
5x35E215.030NoYes4321
5x406x556.890NoYes6621
5x436x556.630NoYes6621
6x516x547.7152YesYes6522
6x516x559.7752YesYes6621
6x546x554.2652YesYes5621
6x547x309.262YesYes5421
6x547x3411.8352YesYes5421
6x587x307.222NoYes4411
6x61E318.220NoYes3221
E3E311.022YesYes2211
7x26E33.422NoYes1221
7x30E34.8252YesYes4211
7x277x3115.542NoYes2411
7x307x314.3552YesYes4411
7x347x3812.7952YesNo4612
1x30NT3.450NoYes2321
1x31NT3.682NoYes3321
E1x50E215.3752YesYes8321
3x283x296.4552YesYes6421
3x293x324.1152YesYes4712
3x326x555.8652YesYes7621
7x28NT2.190NoYes1321
5x34E20.772NoYes1321

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
100.00Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
100.00Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
92.86Consensusneurotensin_onOrthosteric Ligandnts1_on
92.86Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
86.67Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
82.35Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
81.25Single4BUONeurotensin4BUO-NTS1-Neurotensin
81.25Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
80.00Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
80.00Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
80.00Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
80.00Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
78.57Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
76.47Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
75.00Single4XEENeurotensin4XEE-NTS1-Neurotensin
75.00Single4XESNeurotensin4XES-NTS1-Neurotensin
75.00Single6YVRNTS8-136YVR-NTS1-NTS8-13
75.00Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
70.59Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
70.59Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-PubChem 118610427-chim(NtGi1-Go)/β1/γ2
68.75Single4BV0Neurotensin4BV0-NTS1-Neurotensin
68.75Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
66.67Single5T04Neurotensin5T04-NTS1-Neurotensin
64.71Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
64.71Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
64.71Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
64.29Single4BWBNeurotensin4BWB-NTS1-Neurotensin
60.00Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
58.82Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
55.56Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
55.56Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
55.56Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
53.33Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
52.63Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
52.63Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
50.00Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
50.00Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
50.00Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
50.00Single8XQJJN2418XQJ-Apelin-JN241
50.00Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
48.00Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
48.00Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
47.37Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
47.37Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
47.37Single8XQJJN2418XQJ-Apelin-JN241
47.37Single8XWSCXCL58XWS-CXCR2-CXCL5
47.37Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
47.37Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
47.06Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
47.06Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
47.06Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
47.06Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
45.83Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
45.45Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
45.00Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
44.44Single5GLHEndothelin-15GLH-ETB-Endothelin-1
44.44Single6Z4SSR486926Z4S-NTS1-SR48692
44.00Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
44.00Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
44.00Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
43.75Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
43.75Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
43.48Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
43.48Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
43.48Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
43.48Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
43.48Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
42.86Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
42.86Single6KNMJN241-96KNM-Apelin-JN241-9
42.86Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
42.86Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
42.86Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
42.86Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
42.31Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
42.11Single6OS1TRV0266OS1-AT1-TRV026
42.11Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
42.11Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
42.11Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
42.11Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
42.11Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
42.11Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
41.67Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
41.67Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
41.67Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
41.18Single6ZINSR486926ZIN-NTS1-SR48692
41.18Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
41.18Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
40.91Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
40.91Single8XWNCXCL88XWN-CXCR2-CXCL8
40.91Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
40.91Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
40.91Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
40.74Single8IY6Endothelin-18IY6-ETB-Endothelin-1
40.00Single4XNWMRS25004XNW-P2Y1-MRS2500
40.00Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
40.00Single6OS2TRV0266OS2-AT1-TRV026
40.00Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
40.00Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
40.00Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
40.00Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
40.00Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
40.00Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/β1/γ2
40.00Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
40.00Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
40.00Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
40.00Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
40.00Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
40.00Single8XWACXCL18XWA-CXCR2-CXCL1
40.00Single8XWMCXCL68XWM-CXCR2-CXCL6
40.00Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
40.00Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
40.00Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
40.00Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
39.29Single6IGKEndothelin-36IGK-ETB-Endothelin-3
39.29Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
39.29Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
39.29Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
39.13Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
39.13Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
39.13Single7XNACYN1548067XNA-SST2-CYN154806
39.13Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
39.13Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
39.13Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
39.13Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
39.13Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
39.13Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
38.89Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
38.89Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
38.89Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
38.89Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
38.89Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
38.46Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
38.46Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
38.46Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
38.46Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
38.10Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
38.10Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
38.10Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
38.10Single8XVUCXCL28XVU-CXCR2-CXCL2
38.10Single8XWFCXCL38XWF-CXCR2-CXCL3
38.10Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
38.10Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
38.10Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
38.10Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
37.50Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
37.50Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
37.50Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
37.50Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
37.04Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
37.04Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
37.04Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
37.04Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
37.04Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
37.04Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
36.84Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
36.84Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
36.84Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
36.67Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
36.36Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
36.36Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
36.36Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
36.36Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
36.36Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
36.36Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
36.00Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
36.00Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
36.00Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
36.00Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
36.00Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
36.00Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
36.00Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
36.00Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
36.00Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
35.71Single6IGLIRL16206IGL-ETB-IRL1620
35.71Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
35.71Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
35.71Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
35.71Consensusbradykinin_onOrthosteric Ligandbk2_on
35.71Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
35.71Consensusendothelin_onOrthosteric Ligandetb_on eta_on
35.71Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
35.29Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
35.29Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
35.29Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
35.29Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
35.29Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
35.29Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
35.00Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
35.00Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
35.00Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
34.78Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
34.78Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
34.78Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
34.78Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
34.78Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
34.78Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
34.78Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
34.78Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
34.78Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
34.78Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
34.78Consensussomatostatin_offOrthosteric Ligandsst2_off
34.78Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
34.62Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
34.62Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
34.62Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
34.62Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
34.62Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
34.62Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
34.62Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
34.48Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
33.33Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
33.33Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
33.33Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
33.33Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
33.33Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
33.33Single7SK3CXCL127SK3-ACKR3-CXCL12
33.33Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
33.33Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
33.33Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
33.33Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
33.33Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
33.33Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
33.33Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
33.33Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
33.33Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
33.33Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
33.33Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
33.33Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
33.33Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
33.33Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
33.33Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
33.33Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
33.33Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
33.33Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
33.33Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
33.33Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
33.33Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
33.33Consensusp2y_offOrthosteric Ligandp2y1_off
33.33Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
33.33Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
33.33Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
32.14Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
32.14Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
32.00Single3OE0CVX153OE0-CXCR4-CVX15
32.00Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
32.00Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
32.00Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
32.00Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
32.00Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
32.00Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
31.82Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
31.82Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
31.82Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
31.82Consensuscck_onOrthosteric Ligandccka_on cckb_on
31.82Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
31.82Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
31.82Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
31.82Consensuschemerin_onOrthosteric Ligandcml1_on
31.82Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
31.58Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
31.58Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
31.58Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
31.58Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
31.58Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
31.58Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
31.58Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
31.58Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
31.58Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
31.58Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
31.25Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
31.25Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
31.03Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
31.03Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
30.77Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
30.77Single6JODAngiotensin II6JOD-AT2-Angiotensin II
30.77Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
30.77Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
30.77Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
30.77Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
30.43Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
30.43Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
30.43Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
30.43Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
30.43Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
30.43Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
30.43Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
30.43Single8QJ2pN1628QJ2-MC4-pN162-Gs
30.43Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
30.43Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
30.00Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
30.00Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
30.00Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
30.00Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
30.00Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
30.00Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
30.00Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
30.00Consensusbombesin_onOrthosteric Ligandbb2_on
30.00Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
30.00Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
30.00Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
29.63Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
29.63Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
29.63Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
29.63Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
29.63Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
29.63Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
29.63Single8ZRTET-18ZRT-ETB-ET-1
29.63Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
29.63Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
29.63Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
29.63Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
29.41Single4O9RCyclopamine4O9R-SMO-Cyclopamine
29.41Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
29.41Single7UL2SR486927UL2-NTS1-SR48692-Na
29.41Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
29.41Consensusgq_nucleotideOrthosteric Ligandgq_p2y
29.41Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
29.41Consensusneurotensin_offOrthosteric Ligandnts1_off
29.41Consensusnts1_offOrthosteric Ligand7UL2-NTS1-SR48692-Na
29.17Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
29.17Single7F8XNN90567F8X-CCKA-NN9056
29.17Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
29.17Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
29.17Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
29.17Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
29.17Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
29.17Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
29.17Consensuslpl_onOrthosteric Ligands1p_on lpa_on
29.17Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
29.17Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
29.17Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
29.03Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
28.57Single4XT3Fractalkine4XT3-US28-Fractalkine
28.57Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
28.57Single7F1TMIP-1a7F1T-CCR5-MIP-1a
28.57Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
28.57Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
28.57Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
28.57Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
28.57Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
28.57Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
28.57Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
28.57Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
28.57Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
28.57Consensuslpa_onOrthosteric Ligandlpa1_on
28.57Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
28.00Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
28.00Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
28.00Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
28.00Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
28.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
28.00Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
28.00Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
28.00Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
28.00Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
27.78Single4QINSAG1.54QIN-SMO-SAG1.5
27.78Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
27.78Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
27.78Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
27.78Single7F8YDevazepide7F8Y-CCKA-Devazepide
27.78Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
27.78Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
27.78Single8GNGIstradefylline8GNG-A2A-Istradefylline
27.78Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
27.78Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
27.78Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
27.78Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
27.78Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
27.78Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
27.59Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
27.59Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
27.27Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
27.27Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
27.27Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
27.27Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
27.27Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
27.27Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
27.27Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
27.27Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
27.27Single8ZPLHF511168ZPL-CXCR4-HF51116-Cholesterol
27.27Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
27.27Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
27.27Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
27.27Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
27.27Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
27.27Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
27.27Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
27.27Consensuslpa_offOrthosteric Ligandlpa1_off
27.27Consensuslpl_offOrthosteric Ligands1p_off lpa_off
26.92Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
26.92Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
26.92Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
26.92Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
26.92Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
26.92Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
26.92Consensusangiotensin_onOrthosteric Ligandat1_on
26.92Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
26.92Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
26.92Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
26.92Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
26.92Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
26.92Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
26.92Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
26.67Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
26.67Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
26.67Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
26.67Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
26.32Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
26.32Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
26.32Single5UVIZM-2413855UVI-A2A-ZM-241385
26.32Single6MH8ZM-2413856MH8-A2A-ZM-241385
26.32Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
26.32Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
26.32Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
26.32Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
26.32Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
26.32Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
26.32Consensusgrh_offOrthosteric Ligandgnrh1_off
26.09Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
26.09Single7EZCUKA7EZC-A2A-UKA
26.09Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
26.09Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
26.09Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
26.09Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
26.09Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(CtGi1-G13)/β1/γ2
26.09Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
26.09Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
25.93Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
25.93Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
25.93Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
25.93Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
25.93Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
25.93Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
25.93Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
25.81Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
25.71Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
25.71Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
25.00Single3EMLZM-2413853EML-A2A-ZM-241385
25.00Single4QIMANTA XV4QIM-SMO-ANTA XV
25.00Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
25.00Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
25.00Single5WF6UK-4320975WF6-A2A-UK-432097
25.00Single6D27CAY104716D27-DP2-CAY10471
25.00Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
25.00Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
25.00Single6S0LZM-2413856S0L-A2A-ZM-241385
25.00Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
25.00Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
25.00Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
25.00Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
25.00Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
25.00Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
25.00Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
25.00Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
25.00Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
25.00Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
25.00Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
25.00Consensuscck_offOrthosteric Ligandccka_off
25.00Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
25.00Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
25.00Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
25.00Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
25.00Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
25.00Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
25.00Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
25.00Consensushca_on_gpOrthosteric Ligandhca2_on_gp
25.00Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
25.00Consensuskisspeptin_onOrthosteric Ligandkiss1_on
25.00Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
25.00Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
25.00Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
25.00Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
25.00Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
24.24Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
24.14Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
24.14Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
24.14Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
24.14Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
24.00Single4XT1Fractalkine4XT1-US28-Fractalkine
24.00Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
24.00Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
24.00Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
24.00Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
24.00Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
24.00Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
24.00Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/β1/γ2
24.00Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
24.00Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
24.00Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
24.00Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
24.00Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
24.00Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
24.00Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
24.00Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
24.00Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
23.81Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
23.81Single5IUAQ274563485IUA-A2A-Q27456348-Na
23.81Single5N2RPSB-365N2R-A2A-PSB-36-Na
23.81Single5N2SPSB365N2S-A1-PSB36
23.81Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
23.81Single6S0QZM-2413856S0Q-A2A-ZM-241385
23.81Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
23.81Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
23.81Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
23.81Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
23.81Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
23.81Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
23.81Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
23.81Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
23.81Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
23.81Single8GNEKW-63568GNE-A2A-KW-6356-Na
23.81Single8QOTNanobody-E8QOT-μ-Nanobody-E
23.81Single8S4DCMF-0198S4D-Apelin-CMF-019
23.81Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
23.81Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
23.81Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
23.81Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
23.81Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
23.81Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
23.81Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
23.53Single8JPSCCL78JPS-ACKR1-CCL7
23.53Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
23.33Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
23.33Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
23.33Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
23.08Single3QAKUK-4320973QAK-A2A-UK-432097
23.08Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
23.08Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
23.08Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
23.08Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
23.08Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
23.08Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
23.08Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
22.73Single5V56TC1145V56-SMO-TC114
22.73Single5XRAAM115425XRA-CB1-AM11542
22.73Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
22.73Single7FEECP559407FEE-CB1-CP55940-ZCZ011
22.73Single7PX4PSB-21137PX4-A2A-PSB-2113
22.73Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
22.73Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
22.73Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
22.73Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
22.73Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
22.73Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
22.73Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
22.73Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
22.73Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
22.73Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
22.73Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
22.73Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
22.73Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
22.73Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
22.73Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
22.73Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
22.73Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
22.73Consensusrelaxin_onOrthosteric Ligandrxfp4_on
22.73Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
22.58Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
22.58Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
22.58Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
22.22Single5WF5UK-4320975WF5-A2A-UK-432097
22.22Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
22.22Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
22.22Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
22.22Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
22.22Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
22.22Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
22.22Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
22.22Single8HSCFab0468HSC-GPR20-Fab046-Gi1/β1/γ2
22.22Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
22.22Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
22.22Single8YRGFospropofol8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
22.22Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
22.22Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
22.22Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
21.95Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
21.88Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
21.88Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
21.74Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
21.74Single4RWADIPP-NH24RWA-δ-DIPP-NH2
21.74Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
21.74Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
21.74Single6KQICP559406KQI-CB1-CP55940-Org27569
21.74Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
21.74Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
21.74Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.74Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
21.74Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
21.74Consensusorexin_onOrthosteric Ligandox2_on
21.74Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
21.74Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
21.43Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
21.43Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
21.43Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
21.43Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
21.43Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
21.43Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
21.43Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
21.43Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
21.43Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
21.21Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
21.05Single3PWHZM-2413853PWH-A2A-ZM-241385
21.05Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
21.05Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
21.05Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
21.05Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
21.05Single7BR3Elagolix7BR3-GnRH1-Elagolix
21.05Single7F8ULintitript7F8U-CCKA-Lintitript
21.05Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
21.05Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
21.05Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
21.05Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
21.05Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/β1/γ2
21.05Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
21.05Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
20.83Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
20.83Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
20.83Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
20.83Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
20.83Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
20.83Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
20.83Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
20.83Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
20.83Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
20.83Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
20.83Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
20.83Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
20.83Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
20.83Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
20.83Consensusprostanoid_offOrthosteric Ligandep_off dp_off
20.69Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
20.69Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
20.69Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
20.69Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
20.69Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
20.69Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
20.69Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
20.00Single3REYXAC3REY-A2A-XAC
20.00Single4UG2CGS216804UG2-A2A-CGS21680
20.00Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
20.00Single5IU7Q274563465IU7-A2A-Q27456346-Na
20.00Single5IUBQ274563445IUB-A2A-Q27456344-Na
20.00Single5JTBZM-2413855JTB-A2A-ZM-241385
20.00Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
20.00Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
20.00Single6FJ3PTH6FJ3-PTH1-PTH
20.00Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
20.00Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
20.00Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
20.00Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
20.00Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
20.00Single7AROLUF58337ARO-A2A-LUF5833-Na
20.00Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
20.00Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
20.00Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
20.00Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
20.00Single7VV6C48/807VV6-MRGPRX2-C48/80
20.00Single7XN9L-054,5227XN9-SST2-L-054,522
20.00Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
20.00Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
20.00Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
20.00Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
20.00Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
20.00Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
20.00Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
20.00Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
20.00Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
20.00Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
20.00Single8K9LDamgo8K9L-μ-Damgo-VV9-Gi3/β1/γ1
20.00Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
20.00Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
20.00Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
20.00Single8ZPNAMD31008ZPN-CXCR4-AMD3100-Cholesterol
20.00Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
20.00Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
20.00Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
20.00Consensusa2_offOrthosteric Liganda2a_off
20.00Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
20.00Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
20.00Consensushca_onOrthosteric Ligandhca2_on
20.00Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
20.00Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
19.35Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
19.35Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
19.35Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
19.35Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
19.35Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
19.35Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
19.35Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
19.23Single4IARErgotamine4IAR-5-HT1B-Ergotamine
19.23Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
19.23Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
19.23Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
19.23Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
19.23Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
19.23Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
19.23Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
19.23Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
19.23Single8WDTphotoNECA8WDT-A2A-photoNECA
19.23Single8WKYPG-9348WKY-MC4-PG-934
19.23Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
19.23Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
19.05Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
19.05Single5IU8Q274563475IU8-A2A-Q27456347-Na
19.05Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
19.05Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
19.05Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/β1/γ2
19.05Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
19.05Single7PYRPSB-21157PYR-A2A-PSB-2115
19.05Single7V3ZCP559407V3Z-CB1-CP55940
19.05Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
19.05Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
19.05Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
19.05Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
19.05Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
19.05Single8K5DGSK2560738K5D-HCA2-GSK256073
19.05Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
19.05Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
19.05Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
19.05Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
19.05Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
19.05Consensusa3_onOrthosteric Liganda3a_on
18.75Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
18.75Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
18.75Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
18.52Single7SK5CXCL127SK5-ACKR3-CXCL12
18.52Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
18.52Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
18.52Single8IEBA1LYA8IEB-GPR156-A1LYA
18.52Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
18.52Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
18.52Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
18.52Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
18.52Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
18.42Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
18.18Single4JKVTaladegib4JKV-SMO-Taladegib
18.18Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
18.18Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
18.18Single6D26Fevipiprant6D26-DP2-Fevipiprant
18.18Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
18.18Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
18.18Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
18.18Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
18.18Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
18.18Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
18.18Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
18.18Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
18.18Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
18.18Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
18.18Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
18.18Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
18.18Consensusa3_on_gpOrthosteric Liganda3a_on_gp
18.18Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
18.18Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
18.18Consensusadenosine_offOrthosteric Liganda1_off a2_off
18.18Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
18.18Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
18.18Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
18.18Consensusdp_offOrthosteric Liganddp2_off
18.18Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
18.18Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
18.18Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
18.18Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
17.86Single6W25SHU91196W25-MC4-SHU9119-Ca
17.86Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
17.86Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
17.86Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
17.86Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
17.65Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
17.65Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
17.65Single8A2OTheophylline8A2O-A2A-Theophylline-Na
17.65Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
17.65Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/β1/γ2
17.39Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
17.39Single5TZRMK86665TZR-FFA1-MK8666
17.39Single5V57TC1145V57-SMO-TC114
17.39Single5XR8AM8415XR8-CB1-AM841
17.39Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
17.39Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
17.39Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
17.39Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
17.39Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
17.39Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
17.39Single7R0CAVP7R0C-V2-AVP-Arrestin2
17.39Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
17.39Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
17.39Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
17.39Single8E0GBU728E0G-μ-BU72
17.39Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
17.39Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
17.39Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
17.39Single9GE2ML1849GE2-GPR55-ML184-Cholesterol-chim(CtGi1-G13)/β1/γ2
17.39Consensusa2_onOrthosteric Liganda2b_on
17.39Consensusa2_on_gpOrthosteric Liganda2b_on_gp
17.39Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
17.39Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
17.39Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
17.39Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
17.39Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
17.39Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
17.39Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
17.39Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
17.39Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
17.39Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
17.39Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
17.24Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
17.24Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
17.24Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
17.24Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
17.24Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
17.14Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
17.14Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
17.14Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
17.14Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
16.67Single3OE6IT1t3OE6-CXCR4-IT1t
16.67Single4PY02MeSATP4PY0-P2Y12-2MeSATP
16.67Single5TZYMK8666; PubChem 1270535975TZY-FFA1-MK8666; PubChem 127053597
16.67Single6MXTSalmeterol6MXT-β2-Salmeterol
16.67Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
16.67Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
16.67Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
16.67Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
16.67Single7K15MKD0467K15-BLT1-MKD046-Na
16.67Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
16.67Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
16.67Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
16.67Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
16.67Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
16.67Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
16.67Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
16.67Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
16.67Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
16.67Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
16.67Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
16.67Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
16.67Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
16.67Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
16.67Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
16.67Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
16.67Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
16.67Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
16.67Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
16.67Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
16.67Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
16.67Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
16.67Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
16.67Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
16.67Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
16.13Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
16.13Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
16.00Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
16.00Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
16.00Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
16.00Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
16.00Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
16.00Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
16.00Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
16.00Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
16.00Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.00Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
16.00Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
15.79Single3OE9IT1t3OE9-CXCR4-IT1t
15.79Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
15.79Single5L7IVismodegib5L7I-SMO-Vismodegib
15.79Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
15.79Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
15.79Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
15.79Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
15.79Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
15.79Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
15.62Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
15.62Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
15.62Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
15.62Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
15.62Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
15.38Single5ZTYAM102575ZTY-CB2-AM10257
15.38Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
15.38Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
15.38Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
15.38Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
15.38Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
15.38Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
15.15Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
15.15Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
15.15Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
15.15Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
15.15Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
15.15Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
15.15Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
15.15Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
15.00Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
15.00Single3ODUIT1t3ODU-CXCR4-IT1t
15.00Single5ZKQABT-4915ZKQ-PAF-ABT-491
15.00Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
15.00Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.00Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
15.00Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
15.00Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
15.00Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
15.00Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
15.00Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
15.00Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
15.00Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
15.00Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
15.00Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
15.00Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
14.81Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
14.81Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
14.81Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
14.81Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
14.81Single8IEBA1LYA8IEB-GPR156-A1LYA
14.81Single8IEIA1LYA8IEI-GPR156-A1LYA
14.81Single8IEPA1LYA8IEP-GPR156-A1LYA
14.81Single8IEPA1LYA8IEP-GPR156-A1LYA
14.81Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
14.81Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
14.81Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
14.81Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
14.71Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/β1/γ2
14.29Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
14.29Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
14.29Single6AQFZM-2413856AQF-A2A-ZM-241385
14.29Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
14.29Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
14.29Single6TPKRetosiban6TPK-OT-Retosiban
14.29Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
14.29Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
14.29Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
14.29Single7T32ZM-2413857T32-A2A-ZM-241385
14.29Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
14.29Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
14.29Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
14.29Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
14.29Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
14.29Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
14.29Single8IHKAcifran8IHK-HCA3-Acifran
14.29Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
14.29Single8K5CAcipimox8K5C-HCA2-Acipimox
14.29Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
14.29Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
14.29Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
14.29Single8ZPMAMD0708ZPM-CXCR4-AMD070-Cholesterol
14.29Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Cholesterol-Gi1/β1/γ2
14.29Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
14.29Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
14.29Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
14.29Consensusvasop-oxy_offOrthosteric Ligandot_off
13.89Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
13.89Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
13.79Single6PT2KGCHM076PT2-δ-KGCHM07
13.79Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
13.79Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.79Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
13.79Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
13.64Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
13.64Single4YAYZD-71554YAY-AT1-ZD-7155
13.64Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
13.64Single5TGZAM65385TGZ-CB1-AM6538
13.64Single5UENDU1725UEN-A1-DU172
13.64Single5UIGCmpd-15UIG-A2A-Cmpd-1
13.64Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
13.64Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
13.64Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
13.64Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
13.64Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
13.64Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
13.64Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
13.64Single8CU6LJ-45178CU6-A2A-LJ-4517
13.64Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
13.64Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
13.64Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.64Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
13.64Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
13.64Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
13.64Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
13.64Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
13.64Single9IYAONO-97105319IYA-GPR55-ONO-9710531
13.64Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
13.64Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
13.64Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
13.51Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
13.51Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
13.51Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
13.33Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
13.33Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
13.33Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
13.33Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
13.33Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
13.33Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
13.33Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
13.33Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ22
13.33Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
13.33Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
13.33Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
13.33Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
13.33Consensusvasop-oxy_onOrthosteric Ligandv2_on
13.33Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
13.16Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
13.04Single4NTJAZD12834NTJ-P2Y12-AZD1283
13.04Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
13.04Single5C1MBU725C1M-μ-BU72
13.04Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
13.04Single5WQCEMPA5WQC-OX2-EMPA
13.04Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
13.04Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
13.04Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
13.04Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
13.04Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
13.04Single7C4SS1P7C4S-S1P3-S1P
13.04Single7C61Ergotamine7C61-5-HT1B-Ergotamine
13.04Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
13.04Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/β1/γ2
13.04Single7W41PD1762527W41-BB2-PD176252
13.04Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.04Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
13.04Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.04Single8JXSPF-61428JXS-D1-PF-6142
13.04Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
13.04Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
13.04Single8TF5Oleic acid8TF5-GPR6-Oleic acid
13.04Single8WGBW9R8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
13.04Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
13.04Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
13.04Consensusblt_offOrthosteric Ligandblt1_off
13.04Consensusbombesin_offOrthosteric Ligandbb2_off
13.04Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
13.04Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
13.04Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
13.04Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
13.04Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
12.90Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
12.90Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
12.90Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
12.50Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
12.50Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
12.50Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
12.50Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
12.50Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
12.50Single7B6WCyclazosin7B6W-α1b-Cyclazosin
12.50Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
12.50Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
12.50Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
12.50Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
12.50Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
12.50Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
12.50Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
12.50Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
12.50Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
12.50Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
12.50Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
12.50Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
12.50Single8XVLZibotentan8XVL-ETA-Zibotentan
12.50Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
12.50Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
12.50Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
12.50Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
12.50Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
12.50Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
12.50Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
12.50Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
12.50Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
12.50Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
12.50Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
12.12Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
12.12Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
12.12Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
12.00Single4N4WSANT-14N4W-SMO-SANT-1
12.00Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
12.00Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
12.00Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
12.00Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
12.00Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
12.00Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
12.00Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
12.00Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
12.00Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
12.00Single7YITNalfurafine7YIT-κ-Nalfurafine
12.00Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
12.00Single8JJLOlodaterol8JJL-β2-Olodaterol
12.00Single8JWY2-1188JWY-A2A-2-118
12.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
12.00Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.00Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
12.00Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
12.00Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
12.00Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
12.00Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
12.00Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
12.00Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
12.00Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
11.76Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
11.76Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
11.76Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
11.76Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
11.76Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
11.76Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
11.76Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
11.76Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
11.76Single8HS2Fab0468HS2-GPR20-Fab046
11.76Single8PWNTheophylline8PWN-A2A-Theophylline
11.76Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
11.76Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
11.54Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
11.54Single5X93K-87945X93-ETB-K-8794
11.54Single6IBLArformoterol6IBL-β1-Arformoterol
11.54Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
11.54Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
11.54Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
11.54Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
11.54Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
11.54Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
11.54Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
11.54Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
11.54Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
11.54Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.54Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
11.54Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
11.54Consensusendothelin_offOrthosteric Ligandetb_off
11.54Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
11.43Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
11.43Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
11.11Single3NY9ICI118-5513NY9-β2-ICI118-551
11.11Single3RFMCaffeine3RFM-A2A-Caffeine
11.11Single6PT3DPI-2876PT3-δ-DPI-287
11.11Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
11.11Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
11.11Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
11.11Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
11.11Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
11.11Single8IEIA1LYA8IEI-GPR156-A1LYA
11.11Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
11.11Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
11.11Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
11.11Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
11.11Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
10.71Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
10.71Single7QA8Peptide7QA8-STE2-Peptide
10.71Single7QA8Peptide7QA8-STE2-Peptide
10.71Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
10.71Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
10.71Single8KIGSHU91198KIG-MC3-SHU9119-Ca
10.53Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
10.53Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
10.53Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
10.53Single6ME5Agomelatine6ME5-MT1-Agomelatine
10.53Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
10.53Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
10.53Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
10.53Single7WC5Psilocin7WC5-5-HT2A-Psilocin
10.53Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
10.53Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
10.53Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
10.53Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
10.53Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
10.53Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
10.53Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
10.53Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
10.34Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
10.34Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
10.34Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
10.34Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
10.00Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
10.00Single6LI0C176LI0-GPR52-C17
10.00Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
10.00Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
10.00Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
10.00Single6TP4ACT-4622066TP4-OX1-ACT-462206
10.00Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
10.00Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
10.00Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
10.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
10.00Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.00Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
10.00Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
10.00Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
10.00Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
10.00Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
10.00Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
10.00Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
10.00Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
10.00Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
10.00Single8K5BNiacin8K5B-HCA2-Niacin
10.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
10.00Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
10.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.00Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
10.00Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
10.00Single9B9Y7DY9B9Y-CB1-7DY
10.00Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
10.00Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
10.00Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
9.68Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
9.68Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
9.68Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
9.68Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
9.52Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
9.52Single4S0VSuvorexant4S0V-OX2-Suvorexant
9.52Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
9.52Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
9.52Single5U09Taranabant5U09-CB1-Taranabant
9.52Single5WS3EMPA5WS3-OX2-EMPA
9.52Single6B73MP11046B73-κ-MP1104
9.52Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
9.52Single6DS0Ly2660976DS0-5-HT2B-Ly266097
9.52Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
9.52Single6ME9Ramelteon6ME9-MT2-Ramelteon
9.52Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
9.52Single6TODEMPA6TOD-OX1-EMPA-Na
9.52Single6TPJSuvorexant6TPJ-OX2-Suvorexant
9.52Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
9.52Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
9.52Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
9.52Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
9.52Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
9.52Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
9.52Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
9.52Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
9.52Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
9.52Single7XRRLemborexant7XRR-OX2-Lemborexant
9.52Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
9.52Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.52Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.52Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
9.52Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
9.52Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
9.52Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
9.52Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
9.52Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
9.52Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
9.52Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.52Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.52Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
9.52Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
9.52Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
9.52Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
9.52Single9BA0A1AKN9BA0-CB1-A1AKN
9.52Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
9.52Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
9.52Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
9.52Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
9.52Consensusorexin_offOrthosteric Ligandox2_off ox1_off
9.52Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
9.52Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
9.52Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
9.52Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
9.52Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
9.38Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
9.38Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
9.30Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
9.09Single2YDOAdenosine2YDO-A2A-Adenosine
9.09Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
9.09Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
9.09Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
9.09Single4ZJCSB-6740424ZJC-OX1-SB-674042
9.09Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
9.09Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
9.09Single6IQLL7458706IQL-D4-L745870
9.09Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
9.09Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
9.09Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
9.09Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
9.09Single6TP3Nemorexant6TP3-OX1-Nemorexant
9.09Single6TPGEMPA6TPG-OX2-EMPA
9.09Single6TPNHTL66416TPN-OX2-HTL6641
9.09Single6V9SGTPL114036V9S-OX1-GTPL11403
9.09Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
9.09Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
9.09Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
9.09Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
9.09Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
9.09Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
9.09Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
9.09Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
9.09Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
9.09Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
9.09Single8K2WAMG4878K2W-CXCR3-AMG487
9.09Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.09Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
9.09Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
9.09Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.09Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
9.09Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
9.09Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
9.09Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single9BJKNaloxone9BJK-μ-Naloxone-NAM
9.09Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
9.09Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
9.09Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
9.09Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
9.09Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
9.09Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
8.82Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
8.82Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
8.82Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
8.70Single2Y02Carmoterol2Y02-β1-Carmoterol
8.70Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
8.70Single4EJ4Naltrindole4EJ4-δ-Naltrindole
8.70Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
8.70Single5DHGC-355DHG-NOP-C-35
8.70Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
8.70Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
8.70Single6DRXLisuride6DRX-5-HT2B-Lisuride
8.70Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
8.70Single6PS1Timolol6PS1-β2-Timolol
8.70Single6TOTLemborexant6TOT-OX1-Lemborexant
8.70Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
8.70Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
8.70Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
8.70Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
8.70Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
8.70Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
8.70Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
8.70Single7UL4Alvimopan7UL4-μ-Alvimopan
8.70Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
8.70Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
8.70Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
8.70Single7YXAONO-54306087YXA-S1P5-ONO-5430608
8.70Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
8.70Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
8.70Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
8.70Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
8.70Single8RLNLUF58348RLN-A2A-LUF5834
8.70Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
8.70Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
8.70Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
8.70Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
8.70Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
8.70Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
8.70Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
8.70Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
8.70Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
8.70Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
8.70Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
8.70Single9B9ZA1AKO9B9Z-CB1-A1AKO
8.70Single9CHXS-Carazolol9CHX-β2-S-Carazolol
8.70Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
8.70Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
8.70Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
8.70Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
8.70Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
8.70Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
8.70Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
8.57Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
8.33Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
8.33Single5XPRBosentan5XPR-ETB-Bosentan
8.33Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
8.33Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
8.33Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
8.33Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
8.33Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
8.33Single6TP6Filorexant6TP6-OX1-Filorexant
8.33Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
8.33Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
8.33Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
8.33Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
8.33Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
8.33Single7SINNPS-21437SIN-CaS-NPS-2143
8.33Single7SINNPS-21437SIN-CaS-NPS-2143
8.33Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
8.33Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
8.33Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
8.33Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
8.33Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
8.33Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
8.33Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
8.33Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
8.33Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
8.33Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
8.33Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
8.33Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
8.33Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
8.33Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
8.33Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
8.33Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
8.33Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
8.33Single9F34FOB02-04A9F34-D3-FOB02-04A-Go1/β1/γ2
8.33Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
8.33Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
8.33Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
8.33Consensusep_offOrthosteric Ligandep4_off
8.33Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
8.00Single2YDVNECA2YDV-A2A-NECA
8.00Single3P0GBI1671073P0G-β2-BI167107
8.00Single4DJHJDTic4DJH-κ-JDTic
8.00Single4UHRCGS216804UHR-A2A-CGS21680
8.00Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
8.00Single5G53NECA5G53-A2A-NECA-Gs
8.00Single6E59L-7607356E59-NK1-L-760735
8.00Single6H7JIsoprenaline6H7J-β1-Isoprenaline
8.00Single6J20Aprepitant6J20-NK1-Aprepitant
8.00Single6J21Aprepitant6J21-NK1-Aprepitant
8.00Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
8.00Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
8.00Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
8.00Single6TQ7SB-3348676TQ7-OX1-SB-334867
8.00Single6WGTLSD6WGT-5-HT2A-LSD
8.00Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
8.00Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
8.00Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
8.00Single7TUYGSK682753A7TUY-GPR183-GSK682753A
8.00Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
8.00Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
8.00Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
8.00Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
8.00Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
8.00Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
8.00Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
8.00Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
8.00Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
8.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
8.00Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
8.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
8.00Single9F33FOB02-04A9F33-D3-FOB02-04A-Go1/β1/γ2
8.00Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
8.00Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
8.00Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
8.00Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
8.00Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
7.69Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
7.69Single4AMIBucindolol4AMI-β1-Bucindolol
7.69Single4LDEBI1671074LDE-β2-BI167107
7.69Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
7.69Single5X33BIIL2605X33-BLT1-BIIL260
7.69Single6A93Risperidone6A93-5-HT2A-Risperidone
7.69Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
7.69Single7DFPSpiperone7DFP-D2-Spiperone
7.69Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
7.69Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
7.69Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
7.69Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
7.69Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
7.69Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
7.69Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
7.69Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
7.69Single8JJ8Formoterol8JJ8-β2-Formoterol
7.69Single8JWZAB9288JWZ-A2A-AB928-Na
7.69Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
7.69Single8XYIVUF106618XYI-CXCR3-VUF10661
7.69Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
7.69Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
7.69Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
7.69Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
7.69Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
7.69Consensusalpha1_offOrthosteric Ligandalpha1a_off
7.69Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
7.69Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
7.69Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
7.69Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
7.69Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
7.69Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
7.41Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
7.41Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
7.41Single6K1QIRL25006K1Q-ETB-IRL2500
7.41Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
7.41Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
7.41Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
7.41Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
7.41Single7UM4AS26747237UM4-5-HT5A-AS2674723
7.41Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
7.41Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
7.41Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
7.41Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
7.41Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
7.41Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
7.41Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
7.14Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
7.14Single6D35Cholesterol6D35-SMO-Cholesterol
7.14Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
7.14Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
7.14Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
7.14Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
7.14Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
7.14Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
7.14Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
7.14Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-PubChem 7023848
7.14Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
7.14Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626-Phospholipid
7.14Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
7.14Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
7.14Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
7.14Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
7.14Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
7.14Single7DTTCa7DTT-CaS-Ca-Ca
7.14Single7DTTCa7DTT-CaS-Ca-Ca
7.14Single7DTUTryptophan7DTU-CaS-Tryptophan
7.14Single7DTUTryptophan7DTU-CaS-Tryptophan
7.14Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
7.14Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
7.14Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
7.14Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
7.14Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
7.14Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
7.14Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
7.14Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
7.14Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
7.14Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
7.14Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
7.14Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
7.14Single7EB2Baclofen7EB2-GABAB2; GABAB1-Baclofen-rac-BHFF-Gi1/β1/γ2
7.14Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
7.14Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
7.14Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
7.14Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
7.14Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
7.14Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
7.14Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
7.14Single7FIIhCG7FII-LH-hCG-chim(NtGi1-Gs)/β1/γ2
7.14Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
7.14Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
7.14Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
7.14Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
7.14Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
7.14Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
7.14Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
7.14Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
7.14Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
7.14Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
7.14Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
7.14Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
7.14Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
7.14Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
7.14Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
7.14Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
7.14Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
7.14Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
7.14Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
7.14Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
7.14Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
7.14Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
7.14Single7SK9CCX6627SK9-ACKR3-CCX662
7.14Single7T9NM22 Fab7T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
7.14Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
7.14Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
7.14Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
7.14Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
7.14Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
7.14Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
7.14Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
7.14Single7XW7K1-707XW7-TSH-K1-70
7.14Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
7.14Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
7.14Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
7.14Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
7.14Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
7.14Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
7.14Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
7.14Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
7.14Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
7.14Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
7.14Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
7.14Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
7.14Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
7.14Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-NAM563
7.14Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
7.14Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
7.14Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
7.14Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
7.14Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
7.14Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
7.14Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
7.14Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
7.14Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
7.14Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
7.14Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
7.14Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
7.14Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
7.14Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
7.14Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
7.14Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
7.14Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
7.14Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
7.14Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
7.14Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
7.14Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
7.14Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
7.14Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
7.14Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
7.14Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
7.14Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
7.14Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
7.14Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
7.14Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
7.14Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
7.14Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
7.14Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
7.14Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
7.14Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
7.14Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
7.14Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
7.14Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
7.14Single8WG9(2S)-2-amino-4-phosphonobutanoic acid8WG9-mGlu4; mGlu2-(2S)-2-amino-4-phosphonobutanoic acid
7.14Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
7.14Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
7.14Single8WGCLY3792688WGC-mGlu4; mGlu2-LY379268
7.14Single8WGDWAG/WA68WGD-mGlu4; mGlu2-WAG/WA6
7.14Single8WGDWAG/WA68WGD-mGlu4; mGlu2-WAG/WA6
7.14Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
7.14Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
7.14Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.14Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.14Single8WVXNorrin8WVX-LGR4-Norrin
7.14Single8WVYNorrin8WVY-LGR4-Norrin
7.14Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
7.14Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
7.14Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
7.14Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
7.14Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
7.14Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
7.14Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
7.14Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
7.14Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
7.14Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
7.14Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
7.14Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
7.14Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
7.14Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
7.14Single8XUMR-spondin-28XUM-LGR4-R-spondin-2
7.14Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
7.14Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
7.14Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
7.14Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
7.14Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
7.14Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
7.14Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
7.14Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
7.14Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
7.14Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
7.14Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
7.14Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
7.14Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
7.14Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
7.14Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
7.14Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
7.14Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
7.14Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
7.14Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
7.14Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
6.90Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
6.90Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
6.90Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
6.67Single6HLOAprepitant6HLO-NK1-Aprepitant
6.67Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
6.67Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
6.67Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
6.67Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
6.67Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
6.67Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
6.67Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
6.67Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
6.67Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
6.67Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
6.67Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
6.67Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
6.25Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
6.25Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
6.25Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
6.25Single7T9MCS-17 Antibody7T9M-TSH-CS-17 Antibody
6.25Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
5.88Single5MZPCaffeine5MZP-A2A-Caffeine-Na
5.88Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
5.88Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/β1/γ2
5.88Single7UTZTR14027UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
5.88Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/β1/γ2
5.88Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
5.88Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/β1/γ2
5.88Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
5.88Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56Single5L7DCholesterol5L7D-SMO-Cholesterol
5.56Single7T9ITSH7T9I-TSH-TSH-Gs/β1/γ2
5.56Single7WC4Serotonin7WC4-5-HT2A-Serotonin
5.56Single8I2GGlycoprotein hormones alpha chain8I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
5.56Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
5.26Single3OE8IT1t3OE8-CXCR4-IT1t
5.26Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
5.26Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.26Single7Y14Beta-Alanine7Y14-MRGPRD-β-Alanine
5.26Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
5.00Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
5.00Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
5.00Single3UZAGTPL92363UZA-A2A-GTPL9236
5.00Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
5.00Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
5.00Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
5.00Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
5.00Single7Y12Beta-Alanine7Y12-MRGPRD-β-Alanine-Gi1/β1/γ2
5.00Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.00Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
5.00Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.00Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.00Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
5.00Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
5.00Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
5.00Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
5.00Consensus5ht2_onOrthosteric Ligand5ht2b_on
5.00Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.76Single3PBLEticlopride3PBL-D3-Eticlopride
4.76Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
4.76Single6HLLCP999946HLL-NK1-CP99994
4.76Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
4.76Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
4.76Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
4.76Single7SRQLSD7SRQ-5-HT2B-LSD
4.76Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
4.76Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
4.76Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
4.76Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
4.76Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
4.76Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
4.76Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
4.76Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
4.76Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
4.76Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
4.76Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go1/β1/γ2
4.76Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
4.76Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
4.76Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
4.55Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
4.55Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
4.55Single6AKXA4R6AKX-CCR5-A4R
4.55Single6ME2Ramelteon6ME2-MT1-Ramelteon
4.55Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
4.55Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
4.55Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
4.55Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
4.55Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
4.55Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.55Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
4.55Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
4.55Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
4.55Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
4.55Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.55Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
4.55Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
4.55Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
4.55Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
4.55Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.55Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.55Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.55Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
4.55Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
4.55Single8Y0HVUF114188Y0H-CXCR3-VUF11418
4.55Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
4.55Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
4.55Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
4.55Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
4.55Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
4.55Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.55Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
4.55Consensusalpha2_offOrthosteric Ligandalpha2c_off
4.55Consensusangiotensin_offOrthosteric Ligandat1_off
4.55Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
4.55Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
4.35Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
4.35Single3RZECidoxepin3RZE-H1-Cidoxepin
4.35Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
4.35Single4MBSMaraviroc4MBS-CCR5-Maraviroc
4.35Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
4.35Single6KUXRS-799486KUX-α2a-RS-79948
4.35Single6PS0S-Carazolol6PS0-β2-S-Carazolol
4.35Single6PS4ICI118-5516PS4-β2-ICI118-551
4.35Single6PS5S-Propranolol6PS5-β2-S-Propranolol
4.35Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
4.35Single6VI4JDTic6VI4-κ-JDTic
4.35Single6ZG9GSK10347026ZG9-M1-GSK1034702
4.35Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
4.35Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
4.35Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
4.35Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
4.35Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
4.35Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
4.35Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.35Single7UL3Famotidine7UL3-H2-Famotidine
4.35Single7VODCariprazine7VOD-5-HT2A-Cariprazine
4.35Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
4.35Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
4.35Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.35Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.35Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.35Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
4.35Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
4.35Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
4.35Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
4.35Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
4.35Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
4.35Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
4.35Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
4.35Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
4.35Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.35Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
4.35Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
4.35Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.35Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.35Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.35Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.35Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
4.35Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
4.35Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
4.35Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
4.35Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
4.35Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
4.35Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
4.35Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
4.35Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
4.35Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
4.35Consensusalpha1_onOrthosteric Ligandalpha1a_on
4.35Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
4.35Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
4.35Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
4.35Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
4.35Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
4.35Consensusopsins_offOrthosteric Ligandrhodopsin_off
4.35Consensussensory_offOrthosteric Ligandopsins_off
4.17Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
4.17Single2Y04Salbutamol2Y04-β1-Salbutamol
4.17Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
4.17Single3NY8ICI118-5513NY8-β2-ICI118-551
4.17Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
4.17Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
4.17Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
4.17Single4GBRS-Carazolol4GBR-β2-S-Carazolol
4.17Single5DHHSB-6121115DHH-NOP-SB-612111
4.17Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
4.17Single6GPSMK08126GPS-CCR2-MK0812
4.17Single6IIVDaltroban6IIV-TP-Daltroban
4.17Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
4.17Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
4.17Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
4.17Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
4.17Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
4.17Single7BU7BI1671077BU7-β1-BI167107
4.17Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
4.17Single7F83PF-051904577F83-Ghrelin-PF-05190457
4.17Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
4.17Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
4.17Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
4.17Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
4.17Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
4.17Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
4.17Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
4.17Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
4.17Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
4.17Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
4.17Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
4.17Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
4.17Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
4.17Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
4.17Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
4.17Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.17Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.17Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.17Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.17Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.17Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.17Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.17Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.17Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.17Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.17Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
4.17Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
4.17Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
4.17Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
4.17Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
4.17Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
4.17Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
4.17Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
4.17Single8JJOAlprenolol8JJO-β2-Alprenolol
4.17Single8JXRLSD8JXR-D1-LSD
4.17Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
4.17Single8PJKST1718PJK-5-HT1A-ST171-t7m-Gi1/β1/γ1
4.17Single8T1WCVN4248T1W-GPR6-CVN424
4.17Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.17Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.17Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
4.17Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
4.17Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
4.17Single8X63Mepyramine8X63-H1-Mepyramine
4.17Single8X64Desloratadine8X64-H1-Desloratadine
4.17Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
4.17Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
4.17Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
4.17Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
4.17Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
4.17Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
4.17Consensus5ht5_onOrthosteric Ligand5ht5a_on
4.17Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
4.17Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
4.17Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
4.17Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
4.17Consensusalpha2_onOrthosteric Ligandalpha2b_on
4.17Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
4.17Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
4.17Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
4.17Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
4.17Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
4.17Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
4.17Consensusblt_onOrthosteric Ligandblt1_on
4.17Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
4.17Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
4.17Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
4.17Consensusdopamine_offOrthosteric Ligandd2_off d3_off
4.17Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
4.17Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
4.17Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
4.17Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
4.17Consensushistamine_offOrthosteric Ligandh1_off
4.17Consensusleukotriene_onOrthosteric Ligandblt_on
4.17Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
4.00Single2RH1S-Carazolol2RH1-β2-S-Carazolol
4.00Single2Y03Isoprenaline2Y03-β1-Isoprenaline
4.00Single2YCWS-Carazolol2YCW-β1-S-Carazolol
4.00Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
4.00Single5D6LS-Carazolol5D6L-β2-S-Carazolol
4.00Single5JQHS-Carazolol5JQH-β2-S-Carazolol
4.00Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
4.00Single5TVNLSD5TVN-5-HT2B-LSD
4.00Single5X7DS-Carazolol5X7D-β2-S-Carazolol-PubChem 129318963
4.00Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
4.00Single6E67BI1671076E67-β2-BI167107-Gs (fused)
4.00Single6GPXMK08126GPX-CCR2-MK0812
4.00Single6HLPNetupitant6HLP-NK1-Netupitant
4.00Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
4.00Single6LUQHaloperidol6LUQ-D2-Haloperidol
4.00Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
4.00Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
4.00Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
4.00Single6PS6Timolol6PS6-β2-Timolol
4.00Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
4.00Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
4.00Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
4.00Single7WC6LSD7WC6-5-HT2A-LSD
4.00Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
4.00Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
4.00Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
4.00Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.00Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.00Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
4.00Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
4.00Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
4.00Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
4.00Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
4.00Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
4.00Single8XYKVUF106618XYK-CXCR3-VUF10661-Go1/β1/γ2
4.00Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
4.00Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
4.00Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
4.00Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
4.00Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
4.00Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
4.00Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
4.00Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
4.00Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
4.00Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
4.00Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
4.00Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
4.00Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
4.00Consensusamine_offonOrthosteric Ligandamine_off amine_on
4.00Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
4.00Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
4.00Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
4.00Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
4.00Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
4.00Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
4.00Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
4.00Consensustrace-amine_onOrthosteric Ligandta1_on
3.85Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
3.85Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
3.85Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
3.85Single5D5AS-Carazolol5D5A-β2-S-Carazolol
3.85Single5D5BS-Carazolol5D5B-β2-S-Carazolol
3.85Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
3.85Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
3.85Single7P2L4YI7P2L-mGlu5-4YI
3.85Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
3.85Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
3.85Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
3.85Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
3.85Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
3.85Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
3.85Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
3.85Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
3.85Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
3.85Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
3.85Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
3.85Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Cholesterol-Gi1/β1/γ1
3.85Single9BJKNAM9BJK-μ-Naloxone-NAM
3.85Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
3.85Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
3.85Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
3.85Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
3.85Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
3.85Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
3.85Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
3.85Consensustachykinin_offOrthosteric Ligandnk1_off
3.85Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
3.70Single3D4STimolol3D4S-β2-Timolol
3.70Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
3.70Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
3.70Single6CM4Risperidone6CM4-D2-Risperidone
3.70Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
3.70Single6IIURamatroban6IIU-TP-Ramatroban
3.70Single6ZG4HTL00099366ZG4-M1-HTL0009936
3.70Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
3.70Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.70Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
3.70Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
3.70Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
3.70Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
3.70Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
3.70Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
3.70Single8XJNCloprosetnol8XJN-TP-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
3.70Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
3.70Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
3.57Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
3.57Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
3.57Single6H7LDobutamine6H7L-β1-Dobutamine
3.57Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
3.57Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
3.57Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
3.57Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
3.57Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.57Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
3.57Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
3.57Single8XVJMacitentan8XVJ-ETA-Macitentan
3.57Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
3.57Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
3.57Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
3.57Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
3.57Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
3.57Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
3.57Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
3.57Consensustp_onOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
3.57Consensustp_on_gpOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
3.45Single5EE7MK08935EE7-Glucagon-MK0893
3.45Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
3.45Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
3.45Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
3.45Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
3.45Single8X5YAstemizole8X5Y-H1-Astemizole
3.33Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
3.33Single8PKMBefiradol8PKM-5-HT1A-Befiradol-t7m-Gi1/β1/γ1
3.33Single8XFTR-spondin-28XFT-LGR4-R-spondin-2-ZNRF3
3.33Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-Cholesterol-ZNRF3
3.12Single8WVUR-spondin-18WVU-LGR4-R-spondin-1-RNF43
3.12Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-Cholesterol-ZNRF3
3.03Single8XFPR-spondin-28XFP-LGR4-R-spondin-2-ZNRF3
2.78Single8XFSR-spondin-28XFS-LGR4-R-spondin-2-ZNRF3

Consensus Members
Id Members
6OSA 6OSA-NTS1-JMV449-Gi1/β1/γ2
7L0S 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
Net Summary
Imin 2.99
Number of Linked Nodes 1001
Number of Links 1177
Number of Hubs 181
Number of Links mediated by Hubs 692
Number of Communities 29
Number of Nodes involved in Communities 219
Number of Links involved in Communities 319
Path Summary
Number Of Nodes in MetaPath 133
Number Of Links MetaPath 132
Number of Shortest Paths 5625556
Length Of Smallest Path 3
Average Path Length 43.7092
Length of Longest Path 85
Minimum Path Strength 0.63
Average Path Strength 6.02454
Maximum Path Strength 28.385
Minimum Path Correlation 0.7
Average Path Correlation 0.987041
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.31579
Average % Of Corr. Nodes 29.7969
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 53.2755
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following consensuses:
IdComponents
neurotensin_on_gpnts1_on_gp



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