Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:C33 4.414229
2R:R:R40 7.7403
3R:R:L48 5.174228
4R:R:P52 3.87754228
5R:R:L55 3.8354226
6R:R:I64 5.73406
7R:R:N67 5.1025409
8R:R:Q71 3.8175404
9R:R:L72 3.84417
10R:R:F82 7.81254355
11R:R:L88 4.8625409
12R:R:N91 8.255419
13R:R:L93 6.9425419
14R:R:L110 4.1525409
15R:R:Q113 7.472519
16R:R:N114 5.3375419
17R:R:N115 5.965419
18R:R:V120 4.90754137
19R:R:S122 4.76754135
20R:R:R126 6.04254134
21R:R:R135 11.3725419
22R:R:D137 7.8419
23R:R:I141 6.085409
24R:R:V144 4.1754139
25R:R:D147 4.814133
26R:R:S148 4.4545138
27R:R:F149 3.8425409
28R:R:H157 5.9225409
29R:R:W159 7.436519
30R:R:D161 6.8325419
31R:R:P172 4.245409
32R:R:L176 3.7454379
33R:R:L179 3.1154379
34R:R:L182 3.4625408
35R:R:T183 6.4275419
36R:R:L184 3.8275409
37R:R:I192 4.1545198
38R:R:F197 3.57609
39R:R:V205 3.9519
40R:R:H207 6.644519
41R:R:L208 3.8375409
42R:R:H209 7.346519
43R:R:N211 5.624199
44R:R:I213 5.4245199
45R:R:L216 3.275196
46R:R:H219 9.234235
47R:R:C220 5.3254195
48R:R:Y234 9.245416
49R:R:F240 6.6256149
50R:R:L250 5.874149
51R:R:E252 5.1475419
52R:R:H256 14.152519
53R:R:I263 4.59754149
54R:R:P264 4.034149
55R:R:F268 4.14754149
56R:R:N271 4.455149
57R:R:R275 4.4975405
58R:R:L279 4.0375408
59R:R:H293 8.54254387
60R:R:H299 8.124287
61R:R:L301 3.315409
62R:R:H320 8.674287
63R:R:I334 4.41407
64R:R:Q342 3.615408
65R:R:S351 7.0375409
66R:R:I355 4.7408
67R:R:L358 3.48254418
68R:R:I370 4.8225407
69R:R:L372 4.2025418
70R:R:Q373 6.87254298
71R:R:I377 4.64254417
72R:R:Y378 10.15501
73R:R:D395 7.13254299
74R:R:I401 4.32254448
75R:R:R407 9.19754254
76R:R:L425 6.0054449
77R:R:L439 4.1525408
78R:R:L441 5.235408
79R:R:L462 3.4575407
80R:R:V464 6.07754307
81R:R:Y466 4.36754306
82R:R:Y468 8.73659
83R:R:T526 3.37754458
84R:R:F529 6.1175438
85R:R:Y534 8.3725454
86R:R:L535 7.775459
87R:R:M540 7.755455
88R:R:R542 5.75333659
89R:R:F555 9.57254465
90R:R:N556 6.67254479
91R:R:F564 5.544498
92R:R:S573 4.0275445
93R:R:K574 7.495447
94R:R:F576 10.4825406
95R:R:F586 5.415406
96R:R:F605 7.995659
97R:R:F608 7.108504
98R:R:W612 6.34659
99R:R:F623 3.7075404
100R:R:F627 3.46405
101R:R:F634 4.4725407
102R:R:E642 9.878508
103R:R:E686 10.2345524
104R:R:Y687 8.39405
105R:R:P691 4.10167659
106R:R:F696 6.284537
107R:R:T698 4.8975434
108R:R:F718 6.2725506
109R:R:Y725 7.1925518
110R:R:Y729 4.054519
111R:R:E735 4.155406
112R:R:Q742 7.74447
113R:R:M745 6.314547
114R:R:H748 9.055649
115R:R:W751 4.642548
116R:R:L752 8.025449
117R:R:F754 4.875408
118R:R:N756 5.71409
119R:R:F760 4.63254538
120R:R:F768 5.875405
121R:R:I781 6.9675438
122R:R:Y801 10.534549
123R:R:N805 7648
124R:R:K807 4.55143746
125R:R:E810 6.285445
126R:R:L815 4.2254487
127E:E:Y74 6.69254159
128E:E:L81 4.53508
129E:E:F85 6.84754548
130E:E:S86 4.7465269
131E:E:E95 12.7875408
132E:E:H102 5.92167689
133E:E:N110 9.075419
134E:E:E113 5.794519
135E:E:D114 8.495419
136E:E:Y118 6.31758119
137E:E:W120 5.69333609
138E:E:K125 8.3525489
139E:E:Q128 9.255409
140E:E:C136 3.8254569
141E:E:R145 5.165419
142E:E:R149 8.8375419
143E:E:F156 4.41509
144E:E:V158 3.32754269
145E:E:R178 6.185409
146E:E:Y182 8.1265269
147E:E:R202 5.836159
148E:E:R204 10.815409
149E:E:P213 5.334539
150E:E:Y216 7.925639
151E:E:F217 5.87439
152E:E:I221 5.635579
153E:E:K241 10.3625449
154L:L:N50 6.18667689
155L:L:Q56 5.52406
156L:L:F60 7.665419
157L:L:F61 5.532587
158L:L:F62 6.35516
159L:L:L63 4.87489
160L:L:R64 7.6875416
161L:L:Y71 9.634516
162L:L:H76 7.52517
163L:L:Y82 8.065418
164L:L:R86 9.71667619
165L:L:P88 4.545405
166L:L:C93 4.9225419
167L:L:R97 5.735415
168L:L:N100 13.4025408
169L:L:F105 7.532519
170L:L:S106 3.9075418
171L:L:D108 4.555418
172L:L:F109 5.65429718
173L:L:Y118 6.5345125
174L:L:H120 9.0154125
175L:L:C128 4.714129
176L:L:P129 2.9154129
177L:L:E140 6.5025408
178L:L:C141 4.40254129
179S:S:C33 4.414249
180S:S:R40 8.64403
181S:S:V41 4.895407
182S:S:P52 3.87754248
183S:S:L55 3.8354246
184S:S:N67 4.05409
185S:S:Q71 4.9404
186S:S:L72 3.844617
187S:S:F82 7.81254605
188S:S:L110 4.4975409
189S:S:Q113 7.94529
190S:S:N114 5.6875429
191S:S:V120 4.90754167
192S:S:S122 4.76754165
193S:S:R126 6.04254164
194S:S:R135 11.8825429
195S:S:D137 8.636529
196S:S:I141 6.4425409
197S:S:V144 4.1754169
198S:S:D147 4.4854163
199S:S:S148 4.4545168
200S:S:F149 3.8425409
201S:S:R156 7.16509
202S:S:H157 8.3675409
203S:S:W159 6.934529
204S:S:D161 8.0225429
205S:S:P172 3.85409
206S:S:L176 4.094629
207S:S:L182 3.8075408
208S:S:L184 3.8275409
209S:S:I192 4.254208
210S:S:F197 5.134509
211S:S:V204 4.205429
212S:S:V205 4.0675429
213S:S:H207 6.914529
214S:S:L208 3.8375409
215S:S:H209 7.094529
216S:S:N210 8.925409
217S:S:N211 5.624209
218S:S:I213 5.4245209
219S:S:L216 3.275206
220S:S:H219 8.9154635
221S:S:C220 5.3254205
222S:S:F221 5.4275409
223S:S:Y234 9.245426
224S:S:F240 6.446676179
225S:S:L250 6.55754179
226S:S:E252 5.4725429
227S:S:H256 14.152529
228S:S:I263 4.59754179
229S:S:P264 4.034179
230S:S:F268 4.14754179
231S:S:N271 4.7245179
232S:S:G288 3.3775409
233S:S:L301 3.66409
234S:S:F312 6.91498
235S:S:H320 8.44647
236S:S:I331 6.78498
237S:S:I334 4.41407
238S:S:S351 7.0375409
239S:S:N353 5.432599
240S:S:I355 4.326598
241S:S:L358 3.4825498
242S:S:I370 5.1775407
243S:S:L372 4.202598
244S:S:Q373 6.87254318
245S:S:I377 4.6425497
246S:S:Y378 11.8401
247S:S:D395 7.79754319
248S:S:I401 4.32254328
249S:S:I404 3.8754327
250S:S:R407 9.19754274
251S:S:L412 3.26408
252S:S:L425 6.34754329
253S:S:Q438 8.47409
254S:S:L439 3.8765188
255S:S:L441 5.58408
256S:S:L459 4.214187
257S:S:L462 3.45754187
258S:S:V464 5.724187
259S:S:Y466 4.66754186
260S:S:Y468 8.73679
261S:S:T526 3.37754658
262S:S:F529 5.34438
263S:S:Y534 8.1154664
264S:S:L535 8.115479
265S:S:M540 4.794575
266S:S:F555 9.69254585
267S:S:F564 5.544698
268S:S:S573 3.6975465
269S:S:F576 9.5525406
270S:S:S581 4.03254677
271S:S:S583 3.8175405
272S:S:Y590 6.2275405
273S:S:F605 7.995679
274S:S:F608 7.108504
275S:S:W612 5.525679
276S:S:F623 3.3825404
277S:S:F634 3.235407
278S:S:L635 5.7954705
279S:S:E642 9.412508
280S:S:E686 10.4165734
281S:S:P691 4.36333679
282S:S:F696 5.278537
283S:S:T698 4.25434
284S:S:Y725 7.4565728
285S:S:E735 3.3975406
286S:S:D736 7.365404
287S:S:Q742 8.3725467
288S:S:M745 6.594567
289S:S:H748 8.12833669
290S:S:W751 4.255668
291S:S:I753 4.146676339
292S:S:F754 4.162508
293S:S:F768 6.845405
294S:S:I777 4.594536
295S:S:E780 5.33438
296S:S:M782 5.145435
297S:S:L792 5.35254749
298S:S:Y801 12.2425469
299S:S:N805 7668
300S:S:K807 5.702566
301S:S:L815 4.2254687
302S:S:R818 7.695403
303T:T:V64 4.16754119
304T:T:Y74 6.12754119
305T:T:T79 3.47409
306T:T:L81 5.61408
307T:T:F85 6.155408
308T:T:S86 4.9775409
309T:T:E95 12.4975408
310T:T:H102 5.921676109
311T:T:L104 3.59254109
312T:T:N110 8.745429
313T:T:E113 6.024529
314T:T:D114 10.1175429
315T:T:Y116 7.99429
316T:T:Y118 7.327159
317T:T:W120 5.832509
318T:T:K125 8.35254109
319T:T:Q128 9.255409
320T:T:C136 3.0275409
321T:T:R145 6.1625429
322T:T:R149 12.3075429
323T:T:F156 4.41509
324T:T:S172 2.8675405
325T:T:R178 6.8925409
326T:T:P179 3.758509
327T:T:Y182 9.20254759
328T:T:R202 7.43754119
329T:T:R204 11.215119
330T:T:P209 2.54254347
331T:T:P213 4.7025439
332T:T:E215 8.06439
333T:T:Y216 10.526539
334T:T:F217 5.314539
335T:T:I221 4.8925409
336M:M:N50 5.968336109
337M:M:Q56 5.8525406
338M:M:F60 7.13429
339M:M:F61 5.5325107
340M:M:F62 6.35526
341M:M:L63 5.20254109
342M:M:R64 7.1725426
343M:M:Y71 11.06426
344M:M:H76 7.286527
345M:M:Y82 7.8075428
346M:M:R86 10.3517629
347M:M:C93 4.9225429
348M:M:R97 6.0475425
349M:M:N100 13.705408
350M:M:F105 7.622529
351M:M:F109 5.42143728
352M:M:Y118 8.7254215
353M:M:H120 7.8025405
354M:M:R121 5.754505
355M:M:C128 5.04754219
356M:M:P129 2.9154219
357M:M:E140 5.01408
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:G90 R:R:N115 1003.39NoYes199
2L:L:H76 R:R:G90 1004.77YesNo179
3L:L:H76 R:R:A89 25.22074.39YesNo079
4R:R:A89 R:R:Q113 25.08956.06NoYes099
5R:R:G90 R:R:N114 41.91735.09NoYes199
6R:R:A138 R:R:N114 41.61513.13NoYes199
7L:L:R86 R:R:A138 41.55072.77YesNo199
8L:L:R86 R:R:D137 13.833510.72YesYes199
9R:R:D137 R:R:W159 25.17683.35YesYes199
10R:R:D137 R:R:Q113 12.05945.22YesYes199
11R:R:Q113 R:R:R135 11.898517.52YesYes199
12R:R:R135 R:R:W159 11.78577YesYes199
13R:R:N115 R:R:N139 1006.81YesNo099
14R:R:I141 R:R:L136 1004.28YesNo099
15R:R:L136 R:R:L160 1002.77NoNo099
16R:R:L160 R:R:L184 1004.15NoYes099
17L:L:F105 L:L:F109 25.08093.22YesYes198
18L:L:F105 R:R:W159 30.959117.04YesYes199
19L:L:F105 R:R:T183 11.17455.19YesYes199
20R:R:D161 R:R:T183 21.821611.56YesYes199
21L:L:R86 R:R:D161 24.22267.15YesYes199
22R:R:L184 R:R:L208 1002.77YesYes099
23L:L:F109 R:R:Q180 16.56547.03YesNo089
24L:L:R121 R:R:Q180 16.063510.51NoNo059
25R:R:H207 R:R:T183 10.52794.11YesYes199
26L:L:F105 L:L:S106 16.05535.28YesYes198
27R:R:L208 R:R:L232 1004.15YesNo099
28R:R:L216 R:R:P241 10.86493.28YesNo069
29R:R:L230 R:R:L232 1004.15NoNo099
30L:L:D108 L:L:S106 19.6812.94YesYes188
31L:L:D108 R:R:E252 14.63.9YesYes189
32R:R:L230 R:R:L253 1004.15NoNo099
33R:R:F240 R:R:P241 10.95047.22YesNo099
34R:R:F255 R:R:L253 1007.31NoNo099
35R:R:K251 R:R:R275 14.02973.71NoYes095
36R:R:F255 R:R:L279 1004.87NoYes098
37R:R:I303 R:R:L279 1002.85NoYes088
38R:R:I303 R:R:L301 1002.85NoYes089
39R:R:H299 R:R:R275 13.02515.64YesYes075
40R:R:L301 R:R:L324 1002.77YesNo099
41L:L:H76 L:L:L59 1009YesNo077
42L:L:C74 L:L:L59 1003.17NoNo097
43L:L:C55 L:L:C74 1007.28NoNo099
44L:L:C55 L:L:F61 1005.59NoYes097
45L:L:F61 L:L:L63 1007.31YesYes879
46L:L:L63 L:L:Q70 1005.32YesNo098
47L:L:Q70 L:L:R65 10010.51NoNo089
48E:E:V99 L:L:R65 1003.92NoNo079
49E:E:V99 E:E:W120 1009.81NoYes079
50E:E:G150 E:E:W120 1002.81NoYes099
51E:E:G150 E:E:Y118 1002.9NoYes1199
52R:R:L324 R:R:L348 1002.77NoNo099
53R:R:L348 R:R:L350 1008.3NoNo099
54R:R:L350 R:R:L372 1004.15NoYes098
55R:R:I370 R:R:L372 1004.28YesYes078
56R:R:I370 R:R:L394 1002.85YesNo077
57R:R:F385 R:R:L394 1007.31NoNo097
58R:R:F385 R:R:F409 1003.22NoNo098
59R:R:F409 R:R:L418 1006.09NoNo089
60R:R:L418 R:R:L439 1002.77NoYes098
61R:R:L439 R:R:L462 1004.15YesYes087
62R:R:L462 R:R:V464 1004.47YesYes077
63R:R:P465 R:R:V464 1003.53NoYes3097
64R:R:P465 R:R:Y466 1002.78NoYes3096
65R:R:Q469 R:R:V464 10012.89NoYes3097
66R:R:Q469 R:R:Y466 1006.76NoYes3096
67R:R:I610 R:R:Y466 1004.84NoYes076
68E:E:Y118 T:T:R202 1004.12YesYes1199
69T:T:E95 T:T:R202 10015.12YesYes089
70E:E:E95 T:T:E95 1003.81YesYes088
71E:E:E95 E:E:R202 10016.28YesYes089
72E:E:R202 T:T:Y118 1003.09YesYes1599
73T:T:G150 T:T:Y118 1002.9NoYes1599
74T:T:G150 T:T:W120 1002.81NoYes099
75T:T:V99 T:T:W120 59.70219.81NoYes079
76M:M:R65 T:T:V99 59.22413.92NoNo097
77M:M:Q70 M:M:R65 59.071510.51NoNo089
78M:M:L63 M:M:Q70 58.5886.65YesNo098
79M:M:L63 T:T:H102 48.4235.14YesYes1099
80M:M:N50 T:T:H102 18.418.93YesYes1099
81M:M:N50 T:T:K125 13.57189.79YesYes1099
82M:M:D49 T:T:K125 10.17886.91NoYes1069
83E:E:Y118 T:T:R204 1003.09YesYes1199
84T:T:E95 T:T:R204 10019.77YesYes089
85E:E:E95 E:E:R204 10019.77YesYes089
86E:E:R204 T:T:Y118 1003.09YesYes099
87R:R:I610 R:R:Y468 1003.63NoYes079
88R:R:F605 R:R:Y468 1009.28YesYes599
89R:R:P779 R:R:S778 25.77723.56NoNo086
90R:R:E780 R:R:S778 25.90567.19NoNo086
91R:R:E780 T:T:F217 71.49294.66NoYes089
92R:R:I541 T:T:F217 1006.28NoYes079
93R:R:I541 T:T:I221 1004.42NoYes079
94R:R:M540 T:T:I221 1005.83YesYes059
95R:R:M540 R:R:W539 10016.29YesNo559
96R:R:R542 R:R:W539 1003YesNo599
97R:R:L536 R:R:R542 1003.64NoYes559
98R:R:L535 R:R:L536 1002.77YesNo595
99R:R:F605 R:R:L535 10015.83YesYes599
100R:R:D598 R:R:R542 1004.76NoYes599
101R:R:D598 R:R:L535 1009.5NoYes599
102R:R:F529 R:R:P779 25.55748.67YesNo088
103R:R:E780 R:R:I781 45.618.2NoYes088
104R:R:I781 R:R:M782 56.35264.37YesNo385
105R:R:F529 R:R:M782 56.153.73YesNo385
106T:T:F217 T:T:Y216 1005.16YesYes399
107R:R:I781 T:T:Y216 54.711610.88YesYes389
108R:R:F529 R:R:F696 80.44324.29YesYes387
109R:R:F696 R:R:L694 79.85648.53YesNo377
110R:R:L694 R:R:P695 79.56166.57NoNo079
111R:R:P695 R:R:V626 79.26513.53NoNo096
112R:R:G677 R:R:V626 73.92243.68NoNo086
113R:R:F623 R:R:G677 73.32913.01YesNo048
114R:R:F623 R:R:T674 72.46315.19YesNo043
115R:R:F627 R:R:T674 72.16643.89YesNo053
116R:R:A673 R:R:F627 56.66952.77NoYes085
117R:R:A673 R:R:F634 56.37242.77NoYes087
118R:R:F634 R:R:M637 94.09557.46YesNo075
119R:R:F718 R:R:M637 93.091311.2YesNo065
120R:R:F718 R:R:L636 83.54964.87YesNo069
121R:R:L636 R:R:N756 83.04745.49NoYes099
122R:R:N756 R:R:P793 10.08664.89YesNo099
123R:R:I777 R:R:I781 43.61894.42NoYes368
124R:R:I777 R:R:P770 43.41595.08NoNo069
125R:R:P697 R:R:P770 43.00967.79NoNo079
126R:R:L771 R:R:P697 42.80814.93NoNo077
127R:R:F768 R:R:L771 42.604210.96YesNo057
128R:R:F768 R:R:L712 41.78977.31YesNo058
129R:R:F760 R:R:L712 41.1763.65YesNo5388
130R:R:F760 R:R:S715 40.36427.93YesNo087
131R:R:N714 R:R:S715 40.16064.47NoNo097
132R:R:N714 R:R:V711 39.75394.43NoNo099
133R:R:E630 R:R:V711 39.55052.85NoNo089
134R:R:E630 R:R:F634 38.73693.5NoYes087
135R:R:F586 R:R:F627 14.32163.22YesYes065
136R:R:F586 R:R:S628 13.13077.93YesNo068
137R:R:M587 R:R:S628 12.83324.6NoNo068
138R:R:A794 R:R:M587 12.53563.22NoNo086
139R:R:A794 R:R:N584 12.23823.13NoNo089
140R:R:N584 R:R:P798 10.15686.52NoNo099
141R:R:K807 R:R:Y801 15.24763.58YesYes469
142R:R:E810 R:R:K807 16.97664.05YesYes456
143R:R:E810 R:R:L814 15.67287.95YesNo054
144R:R:N756 R:R:N797 71.99569.54YesNo099
145R:R:L752 R:R:N797 70.99066.87YesNo099
146R:R:H748 R:R:L752 60.92316.71YesYes499
147R:R:H748 R:R:Y801 10.080818.51YesYes499
148R:R:H748 R:R:N805 41.79575.1YesYes498
149R:R:M745 R:R:N805 30.72877.01YesYes478
150R:R:M745 R:R:S573 13.10433.07YesYes475
151R:R:R643 R:R:S573 11.59556.59NoYes485
152R:R:E642 R:R:R643 22.18218.61YesNo088
153R:R:M745 R:R:Q742 17.13768.16YesYes477
154R:R:Q742 R:R:R643 11.594611.68YesNo478
155R:R:E642 R:R:F576 10.083415.16YesYes086
156R:R:K747 R:R:W751 14.10864.64NoYes478
157T:T:F225 T:T:I221 44.07236.28NoYes099
158T:T:F222 T:T:F225 43.95762.14NoNo099
159S:S:F765 T:T:F222 41.4323.22NoNo089
160S:S:F765 S:S:F766 41.31718.57NoNo089
161S:S:F766 S:S:V785 41.202213.11NoNo097
162S:S:F789 S:S:V785 41.08725.24NoNo077
163S:S:F789 S:S:L792 40.85722.44NoYes079
164S:S:L792 S:S:L796 39.58762.77YesNo7498
165S:S:L796 S:S:N797 39.47654.12NoNo089
166S:S:L752 S:S:N797 39.361419.22NoNo099
167S:S:H748 S:S:L752 31.74889YesNo099
168L:L:C93 L:L:F60 11.42664.19YesYes199
169L:L:F60 L:L:R86 11.753814.97YesYes199
170S:S:G328 S:S:T327 19.87483.64NoNo079
171S:S:G328 S:S:N353 20.26411.7NoYes079
172S:S:I355 S:S:N353 21.63772.83YesYes989
173S:S:I355 S:S:I377 25.51112.94YesYes987
174S:S:I377 S:S:L372 26.65644.28YesYes978
175S:S:I370 S:S:L372 1004.28YesYes078
176S:S:I370 S:S:L394 1002.85YesNo077
177S:S:L394 S:S:L418 1002.77NoNo079
178S:S:L418 S:S:L439 1002.77NoYes098
179S:S:L439 S:S:L462 1004.15YesYes1887
180S:S:L462 S:S:V464 1004.47YesYes1877
181S:S:P465 S:S:V464 1003.53NoYes1897
182S:S:P465 S:S:Y466 1002.78NoYes1896
183S:S:I610 S:S:Y466 1006.04NoYes076
184S:S:I610 S:S:Y468 1003.63NoYes079
185S:S:F605 S:S:Y468 1009.28YesYes799
186S:S:F605 S:S:L535 10015.83YesYes799
187S:S:D598 S:S:L535 10010.86NoYes799
188S:S:D598 S:S:R542 1003.57NoNo099
189S:S:R542 S:S:W546 10011NoNo099
190S:S:L543 S:S:W546 1003.42NoNo059
191S:S:L543 S:S:M540 1002.83NoYes055
192E:E:I221 S:S:M540 1004.37YesYes5795
193E:E:D218 E:E:I221 1002.8NoYes099
194E:E:D218 E:E:T214 1007.23NoNo099
195E:E:Q212 E:E:T214 1007.09NoNo089
196E:E:P213 E:E:Q212 1003.16YesNo098
197E:E:E215 E:E:P213 1004.72NoYes399
198E:E:E215 T:T:Y216 10014.59NoYes399
199S:S:S351 S:S:T327 14.41943.2YesNo099
200S:S:Q469 S:S:V464 10011.46NoYes1897
201S:S:Q469 S:S:Y466 1006.76NoYes1896
202E:E:I221 S:S:I541 1007.36YesNo097
203E:E:F217 S:S:I541 10012.56YesNo097
204E:E:F217 E:E:Y216 1004.13YesYes399
205E:E:Y216 T:T:M219 1009.58YesNo099
206E:E:M219 T:T:M219 1007.22NoNo099
207E:E:M219 T:T:Y216 10014.37NoYes099
208T:T:D114 T:T:Y116 10013.79YesYes299
209T:T:M101 T:T:Y116 1004.79NoYes099
210T:T:M101 T:T:W120 1004.65NoYes099
211T:T:N169 T:T:S86 13.08635.96NoYes099
212T:T:L168 T:T:S86 15.02419.01NoYes099
213T:T:L168 T:T:V139 15.50855.96NoNo099
214T:T:F156 T:T:V139 15.99293.93YesNo099
215T:T:F156 T:T:V124 17.93075.24YesNo099
216T:T:P103 T:T:V124 18.41523.53NoNo099
217T:T:H102 T:T:P103 18.89479.15YesNo1099
218L:L:C141 L:L:H120 13.55864.42YesYes1295
219L:L:H120 L:L:R121 14.557713.54YesNo1255
220S:S:L350 S:S:L372 1004.15NoYes098
221S:S:L348 S:S:L350 1008.3NoNo099
222S:S:L324 S:S:L348 1002.77NoNo099
223S:S:L301 S:S:L324 1004.15YesNo099
224S:S:I303 S:S:L301 1002.85NoYes089
225S:S:I303 S:S:L279 1002.85NoNo088
226S:S:F255 S:S:L279 1004.87NoNo098
227S:S:F255 S:S:L253 1007.31NoNo099
228S:S:L230 S:S:L253 1004.15NoNo099
229S:S:F221 S:S:L230 59.2124.87YesNo099
230S:S:F197 S:S:F221 52.64934.29YesYes099
231S:S:F197 S:S:L206 33.68823.65YesNo099
232S:S:L182 S:S:L206 66.60164.15YesNo089
233S:S:L158 S:S:L182 88.29912.77NoYes098
234S:S:L134 S:S:L158 1004.15NoNo099
235S:S:L110 S:S:L134 1002.77YesNo099
236S:S:L110 S:S:L86 54.22442.77YesNo098
237S:S:L86 S:S:L88 52.67524.15NoNo089
238S:S:I64 S:S:L88 1004.28NoNo069
239S:S:I64 S:S:L62 83.66088.56NoNo065
240S:S:L62 S:S:V41 77.4642.98NoYes057
241S:S:L230 S:S:L232 1004.15NoNo099
242S:S:L208 S:S:L232 1004.15YesNo099
243S:S:L206 S:S:L208 33.69234.15NoYes099
244S:S:L184 S:S:L208 74.74522.77YesYes099
245S:S:L182 S:S:L184 33.31075.54YesYes089
246S:S:L160 S:S:L184 40.6794.15NoYes099
247S:S:L158 S:S:L160 29.44634.15NoNo099
248S:S:L110 S:S:L112 54.22448.3YesNo099
249S:S:L112 S:S:L88 52.67524.15NoNo099
250S:S:C33 S:S:V41 37.18683.42YesYes097
251S:S:C33 S:S:P52 15.49223.77YesYes2498
252S:S:C33 S:S:L55 15.49843.17YesYes2496
253T:T:D114 T:T:E113 1006.5YesYes299
254M:M:R95 T:T:E113 1005.82NoYes279
255M:M:R95 M:M:Y82 10010.29NoYes278
256M:M:C93 M:M:Y82 1004.03YesYes298
257M:M:C93 M:M:F60 1004.19YesYes299
258M:M:F60 M:M:R86 10012.83YesYes299
259M:M:R86 S:S:D137 62.241710.72YesYes299
260S:S:D137 S:S:W159 50.18783.35YesYes299
261S:S:S133 S:S:W159 23.16674.94NoYes099
262M:M:R86 S:S:D161 1009.53YesYes299
263S:S:D161 S:S:W159 50.18093.35YesYes299
264S:S:T59 S:S:V41 30.9896.35NoYes087
265S:S:S56 S:S:T59 27.89021.6NoNo068
266S:S:F58 S:S:S56 24.79135.28NoNo066
267S:S:I64 S:S:N67 15.49535.66NoYes069
268S:S:F197 S:S:L200 17.43316.09YesNo099
269S:S:L179 S:S:L200 16.66114.15NoNo099
270S:S:L176 S:S:L179 15.49776.92YesNo6299
271S:S:F149 S:S:L176 14.72373.65YesYes099
272S:S:F149 S:S:S148 12.01693.96YesYes098
273S:S:S122 S:S:S148 10.09064.89YesYes1658
274S:S:L136 S:S:L160 10.86684.15NoNo099
275S:S:I141 S:S:L136 10.47915.71YesNo099
276S:S:F58 S:S:F82 12.39586.43NoYes065
277S:S:H157 S:S:S133 15.45535.58YesNo099
278S:S:H157 S:S:R156 13.521111.28YesYes099
279S:S:F240 S:S:F255 23.60727.5YesNo099
280S:S:F240 S:S:P241 15.91417.22YesNo099
281S:S:L216 S:S:P241 15.15473.28YesNo069
282S:S:L173 S:S:L182 10.46322.77NoYes098
283M:M:F105 S:S:W159 76.255615.03YesYes299
284M:M:F105 M:M:F109 1004.29YesYes298
285M:M:F109 S:S:Q180 46.33437.03YesNo089
286S:S:D161 S:S:T183 74.79117.23YesNo099
287M:M:F105 S:S:T183 38.11915.19YesNo099
288S:S:C220 S:S:S217 10.84833.44YesNo056
289S:S:D194 S:S:S217 10.07311.78NoNo086
290M:M:R121 S:S:Q180 44.88865.84YesNo059
291M:M:R121 S:S:V204 59.84923.92YesYes059
292M:M:F109 S:S:V204 60.80945.24YesYes289
293S:S:V204 S:S:V205 20.27354.81YesYes299
294S:S:H207 S:S:V205 32.82712.77YesYes299
295S:S:H207 S:S:T183 36.19416.85YesNo099
296S:S:E228 S:S:V204 19.30892.85NoYes099
297S:S:T229 S:S:V205 12.0764.76NoYes299
298S:S:E228 S:S:K251 13.51888.1NoNo099
299S:S:K251 S:S:R275 14.48316.19NoNo095
300S:S:D297 S:S:R275 14.48265.96NoNo055
301S:S:D297 S:S:H320 11.58613.78NoYes057
302S:S:I370 S:S:L367 10.13758.56YesNo077
303S:S:F385 S:S:T384 10.087211.67NoNo098
304S:S:H748 S:S:N805 21.80635.1YesYes698
305S:S:M745 S:S:N805 18.17045.61YesYes678
306S:S:E642 S:S:R643 17.414718.61YesNo088
307S:S:E642 S:S:F576 13.653712.83YesYes086
308S:S:F576 S:S:L579 12.71318.53YesNo067
309S:S:L579 S:S:L635 12.242412.46NoYes7075
310S:S:L635 S:S:S583 11.30223YesYes055
311S:S:S583 S:S:S631 10.36454.89YesNo055
312S:S:F627 S:S:S631 10.12923.96NoNo055
313M:M:C110 M:M:C124 10.13643.64NoNo7699
314M:M:C124 M:M:N100 16.8946.3NoYes098
315M:M:F117 M:M:N100 33.787822.96NoYes058
316M:M:D126 M:M:F117 43.92393.58NoNo035
317M:M:D126 M:M:E127 47.30265.2NoNo034
318M:M:E127 M:M:P129 50.68126.29NoYes049
319M:M:C141 M:M:P129 57.43791.88NoYes2199
320M:M:C141 M:M:H120 81.08872.95NoYes095
321M:M:H120 M:M:R121 94.60089.03YesYes055
322M:M:K114 M:M:N100 10.13659.79NoYes078
323M:M:C128 M:M:C141 20.27227.28YesNo2199
324M:M:C128 M:M:Y118 10.13645.38YesYes2195
325R:R:I141 R:R:N139 1002.83YesNo099
326R:R:F240 R:R:F255 11.41178.57YesNo099
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
S:S:M66 S:S:S65 3.07 0 No No 9 9 1 2
M:M:H76 S:S:M66 10.51 2 Yes No 7 9 0 1
S:S:A89 S:S:Q113 6.06 0 No Yes 9 9 1 1
M:M:H76 S:S:A89 2.93 2 Yes No 7 9 0 1
S:S:G90 S:S:N114 5.09 2 No Yes 9 9 1 1
M:M:H76 S:S:G90 6.35 2 Yes No 7 9 0 1
S:S:Q113 S:S:T111 5.67 2 Yes No 9 9 1 2
S:S:R135 S:S:T111 7.76 2 Yes No 9 9 2 2
S:S:Q113 S:S:R135 19.86 2 Yes Yes 9 9 1 2
S:S:D137 S:S:Q113 5.22 2 Yes Yes 9 9 1 1
M:M:S77 S:S:Q113 2.89 0 No Yes 7 9 0 1
S:S:A138 S:S:N114 3.13 2 No Yes 9 9 1 1
M:M:K58 S:S:N114 5.6 2 No Yes 8 9 0 1
M:M:H76 S:S:N114 8.93 2 Yes Yes 7 9 0 1
S:S:Q132 S:S:R156 9.35 0 No Yes 8 9 2 1
S:S:H157 S:S:S133 5.58 0 Yes No 9 9 1 2
S:S:S133 S:S:W159 4.94 0 No Yes 9 9 2 1
S:S:D137 S:S:R135 11.91 2 Yes Yes 9 9 1 2
S:S:R135 S:S:W159 8 2 Yes Yes 9 9 2 1
S:S:D137 S:S:W159 3.35 2 Yes Yes 9 9 1 1
S:S:D137 S:S:D161 11.98 2 Yes Yes 9 9 1 1
M:M:R86 S:S:D137 10.72 2 Yes Yes 9 9 0 1
M:M:K58 S:S:A138 3.21 2 No No 8 9 0 1
M:M:R86 S:S:A138 2.77 2 Yes No 9 9 0 1
S:S:H157 S:S:R156 11.28 0 Yes Yes 9 9 1 1
S:S:Q180 S:S:R156 10.51 0 No Yes 9 9 1 1
M:M:E140 S:S:R156 3.49 0 Yes Yes 8 9 0 1
M:M:F109 S:S:H157 5.66 2 Yes Yes 8 9 0 1
M:M:T111 S:S:H157 10.95 0 No Yes 8 9 0 1
S:S:D161 S:S:W159 3.35 2 Yes Yes 9 9 1 1
M:M:F105 S:S:W159 15.03 2 Yes Yes 9 9 0 1
S:S:D161 S:S:T183 7.23 2 Yes No 9 9 1 1
M:M:R86 S:S:D161 9.53 2 Yes Yes 9 9 0 1
S:S:D162 S:S:L186 8.14 0 No No 9 9 1 2
M:M:R86 S:S:D162 21.44 2 Yes No 9 9 0 1
M:M:F109 S:S:Q180 7.03 2 Yes No 8 9 0 1
M:M:R121 S:S:Q180 5.84 0 Yes No 5 9 0 1
M:M:F105 S:S:A181 8.32 2 Yes No 9 9 0 1
M:M:F109 S:S:A181 2.77 2 Yes No 8 9 0 1
S:S:H207 S:S:T183 6.85 2 Yes No 9 9 1 1
M:M:F105 S:S:T183 5.19 2 Yes No 9 9 0 1
S:S:A185 S:S:H209 7.32 0 No Yes 9 9 2 1
S:S:L186 S:S:N210 5.49 0 No Yes 9 9 2 1
M:M:R121 S:S:S202 3.95 0 Yes No 5 8 0 1
S:S:V204 S:S:V205 4.81 2 Yes Yes 9 9 1 1
S:S:E228 S:S:V204 2.85 0 No Yes 9 9 1 1
M:M:F109 S:S:V204 5.24 2 Yes Yes 8 9 0 1
M:M:R121 S:S:V204 3.92 0 Yes Yes 5 9 0 1
S:S:H207 S:S:V205 2.77 2 Yes Yes 9 9 1 1
S:S:T229 S:S:V205 4.76 2 No Yes 9 9 1 1
M:M:F109 S:S:V205 3.93 2 Yes Yes 8 9 0 1
S:S:H207 S:S:H209 9.55 2 Yes Yes 9 9 1 1
S:S:D231 S:S:H207 12.61 2 No Yes 9 9 2 1
M:M:S106 S:S:H207 2.79 0 No Yes 8 9 0 1
S:S:H209 S:S:N210 7.65 2 Yes Yes 9 9 1 1
S:S:D231 S:S:H209 3.78 2 No Yes 9 9 2 1
M:M:H85 S:S:H209 7.17 0 No Yes 4 9 0 1
S:S:N210 S:S:Y234 12.79 0 Yes Yes 9 6 1 2
M:M:P88 S:S:N210 9.77 0 No Yes 5 9 0 1
M:M:R121 S:S:N226 6.03 0 Yes No 5 8 0 1
S:S:E228 S:S:K251 8.1 0 No No 9 9 1 2
M:M:R123 S:S:E228 4.65 0 No No 6 9 0 1
S:S:E252 S:S:T229 7.06 2 Yes No 9 9 1 1
M:M:D108 S:S:T229 7.23 2 No No 8 9 0 1
S:S:E252 S:S:K251 5.4 2 Yes No 9 9 1 2
S:S:E252 S:S:T276 4.23 2 Yes No 9 8 1 2
M:M:D108 S:S:E252 5.2 2 No Yes 8 9 0 1
T:T:V99 T:T:W120 9.81 0 No Yes 7 9 1 2
M:M:R65 T:T:V99 3.92 0 No No 9 7 0 1
T:T:Q100 T:T:V123 2.87 0 No No 7 9 1 2
T:T:Q100 T:T:V195 2.87 0 No No 7 9 1 1
M:M:N50 T:T:Q100 3.96 10 Yes No 9 7 0 1
T:T:M101 T:T:Y116 4.79 0 No Yes 9 9 2 1
T:T:M101 T:T:W120 4.65 0 No Yes 9 9 2 2
T:T:H102 T:T:P103 9.15 10 Yes No 9 9 1 1
T:T:H102 T:T:L104 3.86 10 Yes Yes 9 9 1 1
M:M:N50 T:T:H102 8.93 10 Yes Yes 9 9 0 1
M:M:S53 T:T:H102 2.79 0 No Yes 6 9 0 1
M:M:F61 T:T:H102 5.66 10 Yes Yes 7 9 0 1
M:M:L63 T:T:H102 5.14 10 Yes Yes 9 9 0 1
T:T:P103 T:T:V124 3.53 10 No No 9 9 1 2
M:M:N50 T:T:P103 4.89 10 Yes No 9 9 0 1
M:M:F61 T:T:L104 6.09 10 Yes Yes 7 9 0 1
M:M:M90 T:T:L104 2.83 0 No Yes 5 9 0 1
T:T:N108 T:T:N110 4.09 2 No Yes 9 9 2 1
T:T:E113 T:T:N108 5.26 2 Yes No 9 9 1 2
T:T:E112 T:T:N110 15.77 2 No Yes 9 9 1 1
T:T:E113 T:T:N110 7.89 2 Yes Yes 9 9 1 1
M:M:R97 T:T:N110 7.23 2 Yes Yes 5 9 0 1
M:M:R97 T:T:E112 6.98 2 Yes No 5 9 0 1
T:T:D114 T:T:E113 6.5 2 Yes Yes 9 9 2 1
M:M:R95 T:T:E113 5.82 2 No Yes 7 9 0 1
M:M:R97 T:T:E113 4.65 2 Yes Yes 5 9 0 1
T:T:D114 T:T:Y116 13.79 2 Yes Yes 9 9 2 1
T:T:D114 T:T:R149 9.53 2 Yes Yes 9 9 2 2
T:T:R149 T:T:Y116 3.09 2 Yes Yes 9 9 2 1
M:M:R65 T:T:Y116 10.29 0 No Yes 9 9 0 1
T:T:D157 T:T:K125 13.83 0 No Yes 9 9 2 1
T:T:K125 T:T:M192 2.88 10 Yes No 9 9 1 1
M:M:D49 T:T:K125 6.91 10 No Yes 6 9 0 1
M:M:N50 T:T:K125 9.79 10 Yes Yes 9 9 0 1
M:M:S47 T:T:E127 7.19 10 No No 9 9 0 1
M:M:N50 T:T:E127 5.26 10 Yes No 9 9 0 1
M:M:S53 T:T:E127 5.75 0 No No 6 9 0 1
M:M:S45 T:T:L131 9.01 0 No No 5 9 0 1
M:M:D49 T:T:M192 13.86 10 No No 6 9 0 1
M:M:M68 T:T:V195 4.56 0 No No 8 9 0 1
T:T:K197 T:T:N196 8.39 0 No No 9 9 2 1
M:M:D49 T:T:N196 4.04 10 No No 6 9 0 1
M:M:G67 T:T:K199 5.23 0 No No 8 9 0 1
T:T:L131 T:T:Q128 2.66 0 No Yes 9 9 1 2
M:M:K58 S:S:H140 2.62 2 No No 8 8 0 1
M:M:L63 T:T:G105 1.71 10 Yes No 9 9 0 1
T:T:C136 T:T:L104 1.59 0 Yes Yes 9 9 2 1
T:T:K199 T:T:V200 1.52 0 No No 9 9 1 2
M:M:K41 S:S:M66 1.44 0 No No 6 9 0 1
T:T:N193 T:T:N196 1.36 0 No No 9 9 2 1
S:S:Q154 S:S:R156 1.17 0 No Yes 8 9 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
85.00Single9KB9R-spondin-29KB9-LGR4; LGR4-R-spondin-2-ZNRF3; ZNRF3
71.43Single9KB8R-spondin-29KB8-LGR4-R-spondin-2-ZNRF3; ZNRF3
68.18Single8Y69R-spondin-28Y69-LGR4; LGR4-R-spondin-2-ZNRF3
66.67Single8Y69R-spondin-28Y69-LGR4; LGR4-R-spondin-2-ZNRF3
63.64Single8XFPR-spondin-28XFP-LGR4-R-spondin-2-ZNRF3; ZNRF3
59.09Single8XFSR-spondin-28XFS-LGR4-R-spondin-2-ZNRF3; ZNRF3
59.09Single8XFTR-spondin-28XFT-LGR4-R-spondin-2-ZNRF3
57.14Single8XFPR-spondin-28XFP-LGR4-R-spondin-2-ZNRF3; ZNRF3
52.00Single8XFSR-spondin-28XFS-LGR4-R-spondin-2-ZNRF3; ZNRF3
5.56Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
5.56Single6D35Cholesterol6D35-SMO-Cholesterol
5.56Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
5.56Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
5.56Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
5.56Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
5.56Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042
5.56Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042
5.56Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042
5.56Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-BHFF
5.56Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
5.56Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626
5.56Single7DD5Ca7DD5-CaS; CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.56Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS; CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.56Single7DD5Ca7DD5-CaS; CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.56Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS; CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.56Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
5.56Single7DTTCa7DTT-CaS; CaS-Ca-Ca
5.56Single7DTTCa7DTT-CaS; CaS-Ca-Ca
5.56Single7DTUTryptophan7DTU-CaS; CaS-Tryptophan
5.56Single7DTUTryptophan7DTU-CaS; CaS-Tryptophan
5.56Single7DTVCa7DTV-CaS; CaS-Ca-Ca; Tryptophan
5.56Single7DTVCa; Tryptophan7DTV-CaS; CaS-Ca-Ca; Tryptophan
5.56Single7DTVCa7DTV-CaS; CaS-Ca-Ca; Tryptophan
5.56Single7DTVCa; Tryptophan7DTV-CaS; CaS-Ca-Ca; Tryptophan
5.56Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.56Single7E6TCa7E6T-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.56Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.56Single7E6TCa7E6T-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.56Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
5.56Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
5.56Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
5.56Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
5.56Single7EB2Baclofen7EB2-GABAB2; GABAB1-Baclofen-rac-BHFF-Gi1/β1/γ2
5.56Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
5.56Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
5.56Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
5.56Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
5.56Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
5.56Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
5.56Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
5.56Single7FIIhCG7FII-LH-hCG-chim(NtGi1-Gs)/β1/γ2
5.56Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS; CaS-Ca; Ca; Tryptophan; NPS-2143
5.56Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS; CaS-Ca; Ca; Tryptophan; NPS-2143
5.56Single7M3FCa; Ca; Tryptophan; Cinacalcet7M3F-CaS; CaS-Ca; Ca; Tryptophan; Cinacalcet
5.56Single7M3FCa; Ca; Tryptophan; Cinacalcet7M3F-CaS; CaS-Ca; Ca; Tryptophan; Cinacalcet
5.56Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS; CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.56Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS; CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.56Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS; CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.56Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS; CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.56Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
5.56Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
5.56Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
5.56Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
5.56Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
5.56Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
5.56Single7SILCa7SIL-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4
5.56Single7SILCa; Ca; Ca; Cyclomethyltryptophan; R-568; PO47SIL-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4
5.56Single7SILCa7SIL-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4
5.56Single7SILCa; Ca; Ca; Cyclomethyltryptophan; R-568; PO47SIL-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4
5.56Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.56Single7SIMCa7SIM-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.56Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.56Single7SIMCa7SIM-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.56Single7T9NM22 Fab7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
5.56Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
5.56Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
5.56Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
5.56Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
5.56Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
5.56Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
5.56Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
5.56Single7XW7K1-707XW7-TSH-K1-70
5.56Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
5.56Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
5.56Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
5.56Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
5.56Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
5.56Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
5.56Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
5.56Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
5.56Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
5.56Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
5.56Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
5.56Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
5.56Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-NAM563
5.56Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
5.56Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
5.56Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
5.56Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
5.56Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
5.56Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
5.56Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
5.56Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
5.56Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
5.56Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
5.56Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
5.56Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
5.56Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS; CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
5.56Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS; CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
5.56Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS; CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
5.56Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
5.56Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
5.56Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
5.56Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
5.56Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
5.56Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
5.56Single8TQBCa; LY3792688TQB-mGlu3; mGlu3-Ca; LY379268-Ca
5.56Single8TQBCa; LY3792688TQB-mGlu3; mGlu3-Ca; LY379268-Ca
5.56Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
5.56Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
5.56Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
5.56Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
5.56Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
5.56Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
5.56Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
5.56Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
5.56Single8WG9PubChem 1793948WG9-mGlu4; mGlu2-PubChem 179394
5.56Single8WGBGlutamate8WGB-mGlu4; mGlu2-Glutamate-VU0155041-Gi3/β1/γ2
5.56Single8WGBGlutamate8WGB-mGlu4; mGlu2-Glutamate-VU0155041-Gi3/β1/γ2
5.56Single8WGCLY3792688WGC-mGlu2; mGlu4-LY379268
5.56Single8WGDLY341495; CPPG8WGD-mGlu4; mGlu2-LY341495; CPPG
5.56Single8WGDLY341495; CPPG8WGD-mGlu4; mGlu2-LY341495; CPPG
5.56Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS; CaS-Tryptophan; Cinacalcet; PO4; Ca
5.56Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS; CaS-Tryptophan; Cinacalcet; PO4; Ca
5.56Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS; CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.56Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS; CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.56Single8WVXNorrin8WVX-LGR4-Norrin
5.56Single8WVYNorrin8WVY-LGR4-Norrin
5.56Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
5.56Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
5.56Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
5.56Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
5.56Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
5.56Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
5.56Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
5.56Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
5.56Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU29
5.56Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU29
5.56Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
5.56Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
5.56Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
5.56Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
5.56Single8XUMR-spondin-28XUM-LGR4-R-spondin-2
5.56Single9ASBCa9ASB-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56Single9ASBCa; Ca; Cyclomethyltryptophan; R-568; PO49ASB-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56Single9AVGCa9AVG-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs)/β1/γ2
5.56Single9AVGCa; Ca; Cyclomethyltryptophan; R-568; PO49AVG-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs)/β1/γ2
5.56Single9AVLCa9AVL-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-Gi3/β2/γ2
5.56Single9AVLCa; Ca; Cyclomethyltryptophan; R-568; PO49AVL-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-Gi3/β2/γ2
5.56Single9AVLCa9AVL-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-Gi3/β2/γ2
5.56Single9AVLCa; Ca; Cyclomethyltryptophan; R-568; PO49AVL-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-Gi3/β2/γ2
5.56Single9AXFCa9AXF-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; R-568; PO49AXF-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56Single9AXFCa9AXF-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; R-568; PO49AXF-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56Single9AYFCa9AYF-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4-Gi1/β1/γ2
5.56Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; R-568; PO49AYF-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4-Gi1/β1/γ2
5.56Single9C1PCa9C1P-CaS; CaS-Ca-Ca; Tryptophan; '6218; PO4
5.56Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS; CaS-Ca-Ca; Tryptophan; '6218; PO4
5.56Single9C1PCa9C1P-CaS; CaS-Ca-Ca; Tryptophan; '6218; PO4
5.56Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS; CaS-Ca-Ca; Tryptophan; '6218; PO4
5.56Single9C2FCa9C2F-CaS; CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
5.56Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS; CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
5.56Single9C2FCa9C2F-CaS; CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
5.56Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS; CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
5.56Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2; Arrestin2
5.56Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2; Arrestin2
5.56Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
5.56Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
5.56Single9KB7R-spondin-29KB7-LGR4-R-spondin-2
5.56Single9KGKNB189KGK-LGR4-NB18
5.56Single9KHHNorrin9KHH-LGR4-Norrin
5.56Single9MBAGlutamate9MBA-mGlu8; mGlu8-Glutamate-Arrestin2 ; Arrestin2
5.56Single9MBAGlutamate9MBA-mGlu8; mGlu8-Glutamate-Arrestin2 ; Arrestin2
5.56Single9MBBLY3414959MBB-mGlu8; mGlu8-LY341495
5.56Single9MBBLY3414959MBB-mGlu8; mGlu8-LY341495
5.56Single9MBCDCPG9MBC-mGlu8; mGlu8-DCPG-AZ12216052
5.56Single9MBCDCPG9MBC-mGlu8; mGlu8-DCPG-AZ12216052
5.56Single9S37NB219S37-LGR4-NB21
5.56Single9S38NB219S38-LGR4-NB21
5.56Single9UTBSucralose9UTB-TAS1R2; TAS1R3-Sucralose
5.26Single7DD6Ca7DD6-CaS; CaS-Ca-Ca; Ca; Tryptophan
5.26Single7DD6Ca; Ca; Tryptophan7DD6-CaS; CaS-Ca-Ca; Ca; Tryptophan
5.26Single7DD6Ca7DD6-CaS; CaS-Ca-Ca; Ca; Tryptophan
5.26Single7DD6Ca; Ca; Tryptophan7DD6-CaS; CaS-Ca-Ca; Ca; Tryptophan
5.26Single7DD7Ca7DD7-CaS; CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.26Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS; CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.26Single7DD7Ca7DD7-CaS; CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.26Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS; CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.26Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS; CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
5.26Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS; CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
5.26Single9ASBCa9ASB-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26Single9ASBCa; Ca; Cyclomethyltryptophan; R-568; PO49ASB-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26Single9AVGCa9AVG-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs)/β1/γ2
5.26Single9AVGCa; Ca; Cyclomethyltryptophan; R-568; PO49AVG-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs)/β1/γ2
5.26Single9AYFCa9AYF-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4-Gi1/β1/γ2
5.26Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; R-568; PO49AYF-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4-Gi1/β1/γ2
5.00Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
5.00Single7T9MCS-17 Antibody7T9M-TSH-CS-17 Antibody
4.76Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
4.76Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/β1/γ2
4.76Single7UTZTSH7UTZ-TSH-TSH-DPPC-Gs/β1/γ2
4.76Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/β1/γ2
4.76Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
4.55Single5L7DCholesterol5L7D-SMO-Cholesterol
4.55Single7T9ITSH7T9I-TSH-TSH-Gs/β1/γ2
4.55Single8I2GFSH8I2G-FSH-FSH-PubChem 67530240-Gs/β1/γ2
4.55Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
4.55Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
4.35Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
4.35Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Gi1/β1/γ2
4.35Consensusp2y_offOrthosteric Ligandp2y1_off
4.17Single4XNWMRS25004XNW-P2Y1-MRS2500
4.17Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
4.17Single8JEFPubChem 113671668JEF-HCA3-PubChem 11367166-Gi1/β1/γ2
4.17Single8JPSCCL78JPS-ACKR1-CCL7
4.17Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
4.17Single9IJRC179IJR-GPR52-C17-Arrestin2
4.17Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
4.00Single4O9RCyclopamine4O9R-SMO-Cyclopamine
4.00Single6LI0C176LI0-GPR52-C17
4.00Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
4.00Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab
4.00Single9B9YTaranabant9B9Y-CB1-Taranabant
4.00Single9E7RGB889E7R-PAR2-GB88-chim(NtGi1L-Gs-CtGq)/β1/γ2
4.00Single9MNIdC2_059MNI-CTLike-dC2_05-RAMP1
3.85Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
3.85Single4BWBNeurotensin-(8-12)4BWB-NTS1-Neurotensin-(8-12)
3.85Single4QINSAG1.54QIN-SMO-SAG1.5
3.85Single5U09Taranabant5U09-CB1-Taranabant
3.85Single6LFOCXCL86LFO-CXCR2-CXCL8-Gi1/β1/γ2
3.85Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
3.85Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
3.85Single7BR3Elagolix7BR3-GnRH1-Elagolix
3.85Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
3.85Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
3.85Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
3.85Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
3.85Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
3.85Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
3.85Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
3.85Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
3.85Single8YNFCXCL88YNF-ACKR1-CXCL8
3.85Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
3.85Single9KO2CCL199KO2-CCR7-CCL19-Gi1/β1
3.85Single9KO6CCL199KO6-CCR7-CCL19
3.85Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
3.85Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
3.85Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-CXCL8-Gi1/β1/γ2
3.85Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
3.85Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
3.85Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
3.70Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
3.70Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
3.70Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
3.70Single7UTZDPPC7UTZ-TSH-TSH-DPPC-Gs/β1/γ2
3.70Single7VV6C48/807VV6-MRGPRX2-C48/80
3.70Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
3.70Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
3.70Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
3.70Single9BA0MRI-18919BA0-CB1-MRI-1891
3.70Single9K0KUTP9K0K-P2Y4-UTP-chim(NtGi1-Gs-CtGq)/β1/γ2
3.70Single9K0XATP9K0X-P2Y2-ATP-chim(NtGi1-Gs-CtGq)/β1/γ2
3.70Single9K20ATP9K20-P2Y2-ATP-chim(NtGi1-Go)/β1/γ2
3.70Single9M2FNeuropeptide-FF9M2F-NPFF1-Neuropeptide-FF-Gi1/β1/γ2
3.70Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
3.70Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-CXCL8-Gi1/β1/γ2
3.70Consensusgrh_offOrthosteric Ligandgnrh1_off
3.70Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
3.70Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
3.57Single4QIMANTA XV4QIM-SMO-ANTA XV
3.57Single5T04Neurotensin-(8-13)5T04-NTS1-Neurotensin-(8-13)
3.57Single5TGZAM65385TGZ-CB1-AM6538
3.57Single6D27CAY104716D27-DP2-CAY10471
3.57Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
3.57Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
3.57Single6Z4VNeurotensin-(9-13)6Z4V-NTS1-Neurotensin-(9-13)
3.57Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
3.57Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
3.57Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
3.57Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
3.57Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
3.57Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
3.57Single7VIFFTY720-P7VIF-S1P1-FTY720-P-Gi1/β1/γ2
3.57Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
3.57Single7YXAONO-54306087YXA-S1P5-ONO-5430608
3.57Single8IC0CXCL88IC0-CXCR1-CXCL8-Gi1/β1/γ2
3.57Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
3.57Single9METGp120; CD49MET-CXCR4-Gp120; CD4
3.57Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-CXCL8-Gi1/β1/γ2
3.57Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
3.57Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
3.57Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
3.45Single4JKVTaladegib4JKV-SMO-Taladegib
3.45Single5C1MBU725C1M-μ-BU72
3.45Single6LFMCXCL86LFM-CXCR2-CXCL8-Gi1/β1/γ2
3.45Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
3.45Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
3.45Single7C4SS1P7C4S-S1P3-S1P
3.45Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
3.45Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
3.45Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
3.45Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
3.45Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
3.45Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
3.45Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
3.45Single8ZYTNeurotensin-(8-13)8ZYT-NTS1-Neurotensin-(8-13)-SBI-553-Arrestin2
3.45Single9B9ZMRI-18679B9Z-CB1-MRI-1867
3.45Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
3.45Single9KO4CCL219KO4-CCR7-CCL21-Gi1/β1/γ2
3.45Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-CXCL8-Gi1/β1/γ2
3.45Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
3.45Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
3.45Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
3.45Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
3.33Single3ZEVNeurotensin-(7-13)3ZEV-NTS1-Neurotensin-(7-13)
3.33Single4BV0Neurotensin-(7-13)4BV0-NTS1-Neurotensin-(7-13)
3.33Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
3.33Single5V56TC1145V56-SMO-TC114
3.33Single5V57TC1145V57-SMO-TC114
3.33Single6OS1TRV0266OS1-AT1-TRV026
3.33Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
3.33Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
3.33Single7F1TCCL37F1T-CCR5-CCL3
3.33Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
3.33Single7L0PNeurotensin-(8-13)7L0P-NTS1-Neurotensin-(8-13)-Gi1/β1/γ1
3.33Single7L0QNeurotensin-(8-13)7L0Q-NTS1-Neurotensin-(8-13)-Gi1/β1/γ1
3.33Single7R0CAVP7R0C-V2-AVP-Arrestin2
3.33Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
3.33Single7T9NDPPC7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
3.33Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
3.33Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
3.33Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
3.33Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
3.33Single8FMZNeurotensin-(8-13)8FMZ-NTS1-Neurotensin-(8-13)-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.33Single8FN1Neurotensin-(8-13)8FN1-NTS1-Neurotensin-(8-13)-chim(NtGi1-Go)/β1/γ2
3.33Single8HQCC5a8HQC-C5a1-C5a-Go/β1/γ2
3.33Single8I2GPubChem 675302408I2G-FSH-FSH-PubChem 67530240-Gs/β1/γ2
3.33Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
3.33Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
3.33Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
3.33Single8JZPC5a8JZP-C5a1-C5a-Go/β1/γ2
3.33Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
3.33Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
3.33Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
3.33Single9IZGLPA9IZG-LPA1-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
3.33Single9JCLADP9JCL-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
3.33Single9L16CCL219L16-CCR7-CCL21
3.33Single9MENGp120 (V3 loop)9MEN-CXCR4-Gp120 (V3 loop)
3.33Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
3.33Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
3.33Consensuslpa_onOrthosteric Ligandlpa1_on
3.33Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
3.33Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
3.33Consensusneurotensin_onOrthosteric Ligandnts1_on
3.33Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-(8-13)-Gi1/β1/γ1
3.33Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
3.33Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
3.33Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
3.23Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
3.23Single4XEENeurotensin-(8-13)4XEE-NTS1-Neurotensin-(8-13)
3.23Single4XESNeurotensin-(8-13)4XES-NTS1-Neurotensin-(8-13)
3.23Single6OS0Angiotensin II6OS0-AT1-Angiotensin II
3.23Single6OS2TRV0266OS2-AT1-TRV026
3.23Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
3.23Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
3.23Single6YVRNeurotensin-(6-13)6YVR-NTS1-Neurotensin-(6-13)
3.23Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
3.23Single7EW2FTY720-P7EW2-S1P3-FTY720-P-Gi1/β1/γ2
3.23Single7L0SNeurotensin-(8-13)7L0S-NTS1-Neurotensin-(8-13)-Gi1/β1/γ1
3.23Single7W0NElabela7W0N-Apelin; Apelin-Elabela-Gi1/β1/γ2
3.23Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
3.23Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
3.23Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
3.23Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
3.23Single8T3QDoconexent8T3Q-FFA4-Doconexent-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.23Single8U26Substance-P8U26-NK1-Substance-P-Gs/β1/γ2
3.23Single8XQJJN2418XQJ-Apelin; Apelin-JN241
3.23Single8XWACXCL18XWA-CXCR2-CXCL1
3.23Single8XWMCXCL68XWM-CXCR2-CXCL6
3.23Single8XWSCXCL58XWS-CXCR2-CXCL5
3.23Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
3.23Single9ECJS-geranylgeranyl-L-glutathione9ECJ-P2Y8-S-geranylgeranyl-L-glutathione-G13/β1/γ2
3.23Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
3.23Single9VIFNeuropeptide-VF9VIF-NPFF1-Neuropeptide-VF-Gi1/β1/γ2
3.23Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
3.23Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
3.23Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
3.23Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
3.23Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-(8-13)-Gi1/β1/γ1
3.23Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
3.23Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
3.23Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
3.23Consensuslpa_offOrthosteric Ligandlpa1_off
3.23Consensuslpl_offOrthosteric Ligands1p_off lpa_off
3.23Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-C5-guano-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-DAMGO-Gi1/β1/γ2
3.23Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-C5-guano-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-DAMGO-Gi1/β1/γ2
3.23Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
3.23Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
3.23Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-(8-13)-Gi1/β1/γ1
3.23Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
3.23Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
3.23Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM-5541-Gi1/β1/γ2 7EW2-S1P3-FTY720-P-Gi1/β1/γ2
3.12Single4BUONeurotensin-(8-13)4BUO-NTS1-Neurotensin-(8-13)
3.12Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
3.12Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
3.12Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
3.12Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
3.12Single6UP7Neurotensin-(8-13)6UP7-NTS1-Neurotensin-(8-13)-Arrestin2
3.12Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
3.12Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
3.12Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
3.12Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
3.12Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
3.12Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
3.12Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
3.12Single8E0GBU728E0G-μ-BU72
3.12Single8FN0Neurotensin-(8-13)8FN0-NTS1-Neurotensin-(8-13)-SBI-553-chim(NtGi1-Go)/β1/γ2
3.12Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
3.12Single8JPFNeurotensin-(8-13)8JPF-NTS1-Neurotensin-(8-13)-SBI-553
3.12Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
3.12Single8XVUCXCL28XVU-CXCR2-CXCL2
3.12Single8XWFCXCL38XWF-CXCR2-CXCL3
3.12Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
3.12Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
3.12Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
3.12Single9C0KExendin-49C0K-GLP-1-Exendin-4-Gs/β1/γ2
3.12Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
3.12Single9IZFLPA9IZF-LPA1-LPA-Gi1/β1/γ2
3.12Single9KWXC5a-des-Arg9KWX-C5a1-C5a-des-Arg-Go/β1/γ2
3.12Single9UYMChemerin-99UYM-CML2-Chemerin-9-chim(Arrestin3-CtArrestin2)
3.12Single9WP9S1P9WP9-S1P3-S1P-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.12Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
3.12Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM-5541-Gi1/β1/γ2 7EW2-S1P3-FTY720-P-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
3.12Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
3.12Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
3.03Single5VBLAMG3054 5VBL-Apelin-AMG3054
3.03Single6KNMJN241-96KNM-Apelin-JN241-9
3.03Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
3.03Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
3.03Single7RKFCX3CL17RKF-US28-CX3CL1-GDP-chim(NtGi1-G11)/β1/γ2
3.03Single7RKNCX3CL17RKN-US28-CX3CL1-Gi1/β1/γ2
3.03Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
3.03Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
3.03Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
3.03Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
3.03Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
3.03Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
3.03Single8QJ2pN1628QJ2-MC4-pN162-Gs/β1/γ2
3.03Single8XQJJN2418XQJ-Apelin; Apelin-JN241
3.03Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
3.03Single9KX6C5a-des-Arg9KX6-C5a1-C5a-des-Arg-Go/β1/γ2
3.03Single9UMJEP549UMJ-C3aB-EP54-Go/β1/γ2
3.03Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
3.03Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
3.03Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
3.03Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
3.03Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
2.94Single4XT1CX3CL14XT1-US28-CX3CL1
2.94Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
2.94Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
2.94Single7L0RNeurotensin-(8-13)7L0R-NTS1-Neurotensin-(8-13)-Gi1/β1/γ1
2.94Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
2.94Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
2.94Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
2.94Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
2.94Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
2.94Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
2.94Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
2.94Single8U4OCXCL128U4O-CXCR4-CXCL12-Gi1/β1/γ2
2.94Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
2.94Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
2.94Single8XWNCXCL88XWN-CXCR2-CXCL8
2.94Single8YWFRetatrutide8YWF-GLP-1-Retatrutide-chim(NtGi1-Gs)/β1/γ2
2.94Single9BUECagrilintide9BUE-CT-Cagrilintide-Gs/β1/γ2
2.94Single9KWGC5a9KWG-C5a1-C5a-Go/β1/γ2
2.94Single9L3YChemerin9L3Y-CML2-Chemerin-Gi1/β1/γ2
2.94Single9MEJGp1209MEJ-CXCR4-Gp120
2.94Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
2.94Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
2.94Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
2.94Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
2.94Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
2.94Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-C5-guano-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-DAMGO-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
2.94Consensuslpl_onOrthosteric Ligands1p_on lpa_on
2.94Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
2.94Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
2.94Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
2.94Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
2.94Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
2.86Single6DO1(Sar1,Ile8)-Angiotensin II6DO1-AT1-(Sar1,Ile8)-Angiotensin II
2.86Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
2.86Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
2.86Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
2.86Single7F1QCCL37F1Q-CCR5-CCL3-Gi1/β1/γ2
2.86Single7PIVAfamelanotide7PIV-MC4-Afamelanotide-Gs/β1/γ2
2.86Single7RKMCX3CL17RKM-US28-CX3CL1-Gi1/β1/γ2
2.86Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
2.86Single7SK5CXCL127SK5-ACKR3-CXCL12
2.86Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
2.86Single7VBITirzepatide (non-acylated)7VBI-GLP-1-Tirzepatide (non-acylated)-Gs/β1/γ2
2.86Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
2.86Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
2.86Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
2.86Single8JZZC5a-des-Arg8JZZ-C5a1-C5a-des-Arg-Go/β1/γ2
2.86Single8Z7JJN241-98Z7J-Apelin-JN241-9-Gi1/β1/γ2
2.86Single9ME1CXCL129ME1-CXCR4-CXCL12
2.86Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
2.86Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
2.86Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
2.86Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM-5541-Gi1/β1/γ2 7EW2-S1P3-FTY720-P-Gi1/β1/γ2
2.86Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
2.78Single3OE0CVX153OE0-CXCR4-CVX15
2.78Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
2.78Single6MEOGp160; CD46MEO-CCR5-Gp160; CD4
2.78Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
2.78Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
2.78Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
2.78Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
2.78Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
2.78Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
2.78Single8K6NNeuropeptide-Y8K6N-Y2-Neuropeptide-Y-Gi2/β1/γ1
2.78Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
2.78Single8WVUR-spondin-18WVU-LGR4-R-spondin-1-RNF43
2.78Single8XZHMM078XZH-Apelin; Apelin-MM07-Gi1/β1/γ2
2.78Single8YFOAc-LA-PTH Analog8YFO-PTH1-Ac-LA-PTH Analog-chim(NtGi1-Gs)/β1/γ2
2.78Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
2.78Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
2.78Single9LXRLA-PTH Analog9LXR-PTH1-LA-PTH Analog-Arrestin2
2.78Single9M1ONeuropeptide-FF9M1O-NPFF2-Neuropeptide-FF-Gi1/β1/γ2
2.78Single9MEUCXCL129MEU-CXCR4-CXCL12
2.78Single9U4WGonadoliberin-19U4W-GnRH1-Gonadoliberin-1-chim(NtGi1L-Gs-CtGq)/β1/γ2
2.78Consensusangiotensin_onOrthosteric Ligandat1_on
2.78Consensusat1_onOrthosteric Ligand7F6G-AT1-(Sar1)-Angiotensin II-Gq/β1/γ2
2.78Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-C5a-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a-Gi1/β1/γ2
2.78Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
2.78Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
2.78Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
2.78Consensusclass-b1_class-b2_cons_onOrthosteric Ligandclass-b1_on class-b2_on
2.78Consensusclass-b1_class-b2_cons_on_gpOrthosteric Ligandclass-b1_on_gp class-b2_on_gp
2.78Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
2.78Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
2.78Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
2.78Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
2.70Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
2.70Single6M1IPACAP276M1I-PAC1-PACAP27-Gs/β1/γ2
2.70Single6METGp160; CD46MET-CCR5-Gp160; CD4
2.70Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
2.70Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
2.70Single7F6G(Sar1)-Angiotensin II7F6G-AT1-(Sar1)-Angiotensin II-Gq/β1/γ2
2.70Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
2.70Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
2.70Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
2.70Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
2.70Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
2.70Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
2.70Single8XZJWN3538XZJ-Apelin; Apelin-WN353-Gi1/β1/γ2
2.70Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
2.70Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ2
2.70Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
2.70Single9BLCCagrilintide (non-acylated)9BLC-CT-Cagrilintide (non-acylated)-Gs/β1/γ2
2.70Single9BUDCagrilintide9BUD-CT-Cagrilintide-Gs/β1/γ2
2.70Single9EBOGLP-1 (ACPC18)9EBO-GLP-1-GLP-1 (ACPC18)-Gs/β1/γ2
2.70Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
2.70Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-(Sar1)-Angiotensin II-Gq/β1/γ2
2.70Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-C5a-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a-Gi1/β1/γ2
2.70Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
2.70Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
2.70Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
2.70Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-(Sar1)-Angiotensin II-Gq/β1/γ2
2.70Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
2.70Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
2.70Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
2.70Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
2.70Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
2.70Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
2.70Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
2.70Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
2.70Consensusvasop-oxy_onOrthosteric Ligandv2_on
2.70Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
2.63Single5YQZNNC17025YQZ-Glucagon-NNC1702
2.63Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
2.63Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
2.63Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
2.63Single7F9YGhrelin7F9Y-Ghrelin-Ghrelin-chim(NtGi1-Gs-CtGq)/β1/γ2
2.63Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
2.63Single7P02Substance-P7P02-NK1-Substance-P-chim(NtGi1-Gs)/β1/γ2
2.63Single7TYHCalcitonin7TYH-CT (AMY2)-Calcitonin-Gs/β1/γ2; RAMP2
2.63Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
2.63Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
2.63Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
2.63Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
2.63Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
2.63Single7Y64C5a7Y64-C5a1-C5a-Gi1/β1/γ2
2.63Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
2.63Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
2.63Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
2.63Single8HK5C5a8HK5-C5a1-C5a-Gi1/β1/γ2
2.63Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
2.63Single8IA2C5a8IA2-C5a1-C5a-Go/β1/γ2
2.63Single8XQEApelin-138XQE-Apelin; Apelin-Apelin-13-Gi1/β1/γ2
2.63Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
2.63Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
2.63Single8YG4LA-PTH Analog8YG4-PTH1-LA-PTH Analog-chim(NtGi1-Gs)/β1/γ2
2.63Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGi1)/β1/γ2
2.63Single9E2AGLP-19E2A-GLP-1-GLP-1-Gs/β1/γ2
2.63Single9JFYNeuropeptide-SF9JFY-NPFF2-Neuropeptide-SF-Gi1/β1/γ2
2.63Consensuscalcitonin_onOrthosteric Ligandctlike_on
2.63Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
2.63Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
2.63Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
2.63Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
2.63Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
2.63Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
2.63Consensusgi_apelinOrthosteric Ligand8XZH-Apelin; Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin; Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin; Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin; Apelin-Apelin-13-Gi1/β1/γ2
2.63Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-CXCL8-Gi1/β1/γ2 6LFM-CXCR2-CXCL8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-CCL3-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
2.63Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
2.63Consensuspac_onOrthosteric Ligandpac1_on
2.63Consensusvpac1_onOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
2.63Consensusvpac_onOrthosteric Ligandvpac1_on vpac2_on
2.56Single4XT3CX3CL14XT3-US28-CX3CL1
2.56Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
2.56Single6FJ3PTH6FJ3-PTH1-PTH
2.56Single6NBFLA-PTH Analog6NBF-PTH1-LA-PTH Analog-Gs/β1/γ2
2.56Single6NBILA-PTH Analog6NBI-PTH1-LA-PTH Analog-Gs/β1/γ2
2.56Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
2.56Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
2.56Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
2.56Single7SK3CXCL127SK3-ACKR3-CXCL12
2.56Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
2.56Single7VABTirzepatide (non-acylated)7VAB-GIP-Tirzepatide (non-acylated)-chim(NtGi1-Gs)/β1/γ2
2.56Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
2.56Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
2.56Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
2.56Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
2.56Single9BLBCagrilintide (non-acylated)9BLB-CT-Cagrilintide (non-acylated)-Gs/β1/γ2
2.56Single9BLWCagrilintide (non-acylated)9BLW-CT (AMY1)-Cagrilintide (non-acylated)-Gs/β1/γ2; RAMP1
2.56Single9BP3Cagrilintide9BP3-CT (AMY1)-Cagrilintide-Gs/β1/γ2; RAMP1
2.56Single9BUBCagrilintide9BUB-CT-Cagrilintide-Gs/β1/γ2
2.56Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
2.56Single9P92VIP9P92-PAC1-VIP-Gs/β1/γ2
2.56Consensuscalcitonin_on_gpOrthosteric Ligandctlike_on_gp
2.56Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
2.56Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-CCL3-Gi1/β1/γ2
2.56Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
2.56Consensuscrf2_on_gpOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
2.56Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
2.56Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-C5a-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a-Gi1/β1/γ2 7Y64-C5a1-C5a-Gi1/β1/γ2
2.56Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
2.56Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
2.56Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
2.56Consensuspac1_onOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
2.56Consensuspac1_on_gpOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
2.56Consensuspac_on_gpOrthosteric Ligandpac1_on_gp
2.56Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
2.56Consensusvpac1_on_gpOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
2.56Consensusvpac_on_gpOrthosteric Ligandvpac1_on_gp vpac2_on_gp
2.50Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
2.50Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
2.50Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
2.50Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
2.50Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
2.50Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
2.50Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
2.50Single7S1MExendin-4-D-Ala7S1M-GLP-1-Exendin-4-D-Ala-Gs/β1/γ2
2.50Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
2.50Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
2.50Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
2.50Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
2.50Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
2.50Single8FU6ZP37808FU6-Glucagon-ZP3780-Gs/β1/γ2
2.50Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
2.50Single8ZH8QRFP268ZH8-QRFP-QRFP26-Gq/β1/γ1
2.50Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
2.50Single9BUCCagrilintide9BUC-CT-Cagrilintide-Gs/β1/γ2
2.50Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
2.50Single9P94PACAP279P94-PAC1-PACAP27-Gs/β1/γ2
2.50Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
2.50Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
2.50Consensusglp2_on_gpOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
2.50Consensusglp_onOrthosteric Ligandglp1_on glp2_on
2.50Consensusglp_on_gpOrthosteric Ligandglp1_on_gp glp2_on_gp
2.50Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
2.50Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
2.50Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
2.50Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
2.50Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
2.44Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
2.44Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
2.44Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
2.44Single6NBHLA-PTH Analog6NBH-PTH1-LA-PTH Analog-Gs/β1/γ2
2.44Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
2.44Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
2.44Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
2.44Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
2.44Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
2.44Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
2.44Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
2.44Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
2.44Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
2.44Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
2.44Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
2.44Single8IY6Endothelin-18IY6-ETB-Endothelin-1
2.44Single9BQ3Cagrilintide9BQ3-CT (AMY2)-Cagrilintide-Gs/β1/γ2; RAMP2
2.44Single9BTWCagrilintide9BTW-CT (AMY3)-Cagrilintide-Gs/β1/γ2; RAMP3
2.44Single9BYOExendin-39BYO-GLP-1-Exendin-3-Gs/β1/γ2
2.44Single9P93VIP9P93-PAC1-VIP-Gs/β1/γ2
2.44Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
2.44Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
2.44Consensusbradykinin_onOrthosteric Ligandbk2_on
2.44Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
2.44Consensusctlike_on_gpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
2.44Consensusendothelin_onOrthosteric Ligandetb_on eta_on
2.44Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
2.44Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
2.44Consensuspth1_onOrthosteric Ligand6NBF-PTH1-LA-PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-PTH-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
2.44Consensusvip-pacap_onOrthosteric Ligandvpac_on pac_on
2.44Consensusvip-pacap_on_gpOrthosteric Ligandvpac_on_gp pac_on_gp
2.44Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
2.44Consensusvpac2_on_gpOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
2.38Single5GLHEndothelin-15GLH-ETB-Endothelin-1
2.38Single6IGKEndothelin-36IGK-ETB-Endothelin-3
2.38Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
2.38Single7RBTTirzepatide7RBT-GIP-Tirzepatide-LSN3556672-chim(NtGi1-Gs)/β1/γ2
2.38Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
2.38Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
2.38Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-CCL3-Gi1/β1/γ2
2.38Consensusclass-a_class-b1_cons_onOrthosteric Ligandclass-a_on class-b1_on
2.38Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
2.38Consensusgip_onOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
2.38Consensusgip_on_gpOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
2.38Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
2.38Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
2.33Single6LPBPACAP276LPB-PAC1-PACAP27-Gs/β1/γ1
2.33Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
2.33Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
2.33Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
2.33Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
2.33Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
2.33Single8FLULA-PTH Analog8FLU-PTH1-LA-PTH Analog-Gs/β1/γ2
2.33Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
2.33Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
2.33Consensusglp1_onOrthosteric Ligand7S1M-GLP-1-Exendin-4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Tirzepatide (non-acylated)-Gs/β1/γ2
2.33Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
2.33Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
2.27Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
2.27Single6WPWZP37806WPW-Glucagon-ZP3780-Gs/β1/γ2
2.27Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
2.27Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
2.27Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
2.27Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
2.27Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
2.27Consensuscrf_on_gpOrthosteric Ligandcrf2_on_gp crf1_on_gp
2.27Consensusglp1_on_gpOrthosteric Ligand7S1M-GLP-1-Exendin-4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Tirzepatide (non-acylated)-Gs/β1/γ2
2.27Consensuspth1_on_gpOrthosteric Ligand6NBF-PTH1-LA-PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-PTH-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
2.22Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
2.22Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
2.22Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
2.22Single7Y36PTH7Y36-PTH1-PTH-Gs/β1/γ2
2.22Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
2.22Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
2.22Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
2.22Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
2.22Consensusclass-a_class-b1_cons_on_gpOrthosteric Ligandclass-a_on_gp class-b1_on_gp
2.22Consensusglucagon_onOrthosteric Ligandglp_on gluc_on secretin_on gip_on
2.22Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
2.17Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
2.17Consensusgluc_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
2.17Consensusglucagon_on_gpOrthosteric Ligandglp_on_gp gluc_on_gp secretin_on_gp gip_on_gp
2.17Consensuspth_onOrthosteric Ligandpth1_on pth2_on
2.13Consensusgluc_on_gpOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
2.13Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
2.13Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
2.08Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
2.08Consensusclass-b1_onOrthosteric Ligandglucagon_on vip-pacap_on pth_on crf_on calcitonin_on
2.08Consensuspth2_on_gpOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
2.04Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
2.00Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
2.00Consensuspth_on_gpOrthosteric Ligandpth1_on_gp pth2_on_gp
1.92Consensusclass-b1_on_gpOrthosteric Ligandglucagon_on_gp vip-pacap_on_gp pth_on_gp crf_on_gp calcitonin_on_gp
1.89Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1

2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:M66 R:R:S65 3.07 0 No No 9 9 1 2
L:L:H76 R:R:M66 10.51 1 Yes No 7 9 0 1
R:R:A89 R:R:Q113 6.06 0 No Yes 9 9 1 1
L:L:H76 R:R:A89 4.39 1 Yes No 7 9 0 1
R:R:G90 R:R:N114 5.09 1 No Yes 9 9 1 1
R:R:G90 R:R:N115 3.39 1 No Yes 9 9 1 2
L:L:H76 R:R:G90 4.77 1 Yes No 7 9 0 1
R:R:Q113 R:R:T111 5.67 1 Yes No 9 9 1 2
R:R:R135 R:R:T111 9.06 1 Yes No 9 9 2 2
R:R:Q113 R:R:R135 17.52 1 Yes Yes 9 9 1 2
R:R:D137 R:R:Q113 5.22 1 Yes Yes 9 9 1 1
L:L:S77 R:R:Q113 2.89 0 No Yes 7 9 0 1
R:R:A138 R:R:N114 3.13 1 No Yes 9 9 1 1
L:L:K58 R:R:N114 4.2 1 No Yes 8 9 0 1
L:L:H76 R:R:N114 8.93 1 Yes Yes 7 9 0 1
R:R:Q132 R:R:R156 10.51 0 No No 8 9 2 1
R:R:H157 R:R:S133 4.18 0 Yes No 9 9 1 2
R:R:S133 R:R:W159 4.94 0 No Yes 9 9 2 1
R:R:D137 R:R:R135 11.91 1 Yes Yes 9 9 1 2
R:R:R135 R:R:W159 7 1 Yes Yes 9 9 2 1
R:R:D137 R:R:W159 3.35 1 Yes Yes 9 9 1 1
L:L:R86 R:R:D137 10.72 1 Yes Yes 9 9 0 1
L:L:K58 R:R:A138 3.21 1 No No 8 9 0 1
L:L:R86 R:R:A138 2.77 1 Yes No 9 9 0 1
R:R:H157 R:R:R156 5.64 0 Yes No 9 9 1 1
L:L:E140 R:R:R156 8.14 0 Yes No 8 9 0 1
L:L:F109 R:R:H157 5.66 1 Yes Yes 8 9 0 1
L:L:T111 R:R:H157 8.21 0 No Yes 8 9 0 1
R:R:T183 R:R:W159 4.85 1 Yes Yes 9 9 1 1
L:L:F105 R:R:W159 17.04 1 Yes Yes 9 9 0 1
R:R:D161 R:R:D162 3.99 1 Yes No 9 9 1 1
R:R:D161 R:R:T183 11.56 1 Yes Yes 9 9 1 1
R:R:A185 R:R:D161 4.63 0 No Yes 9 9 2 1
L:L:R86 R:R:D161 7.15 1 Yes Yes 9 9 0 1
R:R:D162 R:R:L186 6.79 1 No No 9 9 1 1
L:L:R86 R:R:D162 17.87 1 Yes No 9 9 0 1
L:L:F109 R:R:Q180 7.03 1 Yes No 8 9 0 1
L:L:R121 R:R:Q180 10.51 12 No No 5 9 0 1
L:L:F105 R:R:A181 6.93 1 Yes No 9 9 0 1
L:L:F109 R:R:A181 4.16 1 Yes No 8 9 0 1
R:R:H207 R:R:T183 4.11 1 Yes Yes 9 9 1 1
L:L:F105 R:R:T183 5.19 1 Yes Yes 9 9 0 1
R:R:A185 R:R:H209 7.32 0 No Yes 9 9 2 1
L:L:P88 R:R:L186 4.93 0 Yes No 5 9 0 1
R:R:V204 R:R:V205 4.81 1 No Yes 9 9 1 1
R:R:E228 R:R:V204 2.85 0 No No 9 9 1 1
L:L:F109 R:R:V204 6.55 1 Yes No 8 9 0 1
R:R:H207 R:R:V205 2.77 1 Yes Yes 9 9 1 1
R:R:T229 R:R:V205 4.76 1 No Yes 9 9 1 1
L:L:S106 R:R:V205 3.23 1 Yes Yes 8 9 0 1
L:L:F109 R:R:V205 3.93 1 Yes Yes 8 9 0 1
R:R:H207 R:R:H209 9.55 1 Yes Yes 9 9 1 1
R:R:D231 R:R:H207 12.61 1 No Yes 9 9 2 1
L:L:S106 R:R:H207 4.18 1 Yes Yes 8 9 0 1
R:R:H209 R:R:N210 7.65 1 Yes No 9 9 1 1
R:R:D231 R:R:H209 5.04 1 No Yes 9 9 2 1
L:L:H85 R:R:H209 7.17 0 No Yes 4 9 0 1
R:R:N210 R:R:Y234 12.79 0 No Yes 9 6 1 2
L:L:P88 R:R:N210 9.77 0 Yes No 5 9 0 1
R:R:E228 R:R:K251 8.1 0 No No 9 9 1 2
L:L:R123 R:R:E228 4.65 0 No No 6 9 0 1
R:R:E252 R:R:T229 7.06 1 Yes No 9 9 1 1
L:L:D108 R:R:T229 7.23 1 Yes No 8 9 0 1
R:R:E252 R:R:K251 5.4 1 Yes No 9 9 1 2
R:R:E252 R:R:T276 4.23 1 Yes No 9 8 1 2
L:L:D108 R:R:E252 3.9 1 Yes Yes 8 9 0 1
E:E:I98 E:E:V123 3.07 0 No No 8 9 1 2
E:E:A203 E:E:I98 3.25 0 No No 9 8 2 1
E:E:I98 L:L:M68 2.92 0 No No 8 8 1 0
E:E:V99 E:E:W120 9.81 0 No Yes 7 9 1 2
E:E:V99 L:L:R65 3.92 0 No No 7 9 1 0
E:E:Q100 E:E:V195 2.87 0 No No 7 9 1 2
E:E:Q100 L:L:N50 3.96 0 No Yes 7 9 1 0
E:E:M101 E:E:Y116 3.59 0 No No 9 9 2 1
E:E:M101 E:E:W120 4.65 0 No Yes 9 9 2 2
E:E:H102 E:E:P103 9.15 8 Yes No 9 9 1 1
E:E:H102 E:E:L104 3.86 8 Yes No 9 9 1 1
E:E:H102 L:L:N50 8.93 8 Yes Yes 9 9 1 0
E:E:H102 L:L:S53 2.79 8 Yes No 9 6 1 0
E:E:H102 L:L:F61 5.66 8 Yes Yes 9 7 1 0
E:E:H102 L:L:L63 5.14 8 Yes Yes 9 9 1 0
E:E:P103 E:E:V124 3.53 8 No No 9 9 1 2
E:E:P103 L:L:N50 4.89 8 No Yes 9 9 1 0
E:E:L104 L:L:F61 6.09 8 No Yes 9 7 1 0
E:E:L104 L:L:M90 2.83 8 No No 9 5 1 0
E:E:N108 E:E:N110 4.09 1 No Yes 9 9 2 1
E:E:E113 E:E:N108 6.57 1 Yes No 9 9 1 2
E:E:E112 E:E:N110 17.09 1 No Yes 9 9 1 1
E:E:E113 E:E:N110 7.89 1 Yes Yes 9 9 1 1
E:E:N110 L:L:R97 7.23 1 Yes Yes 9 5 1 0
E:E:E112 L:L:R97 5.82 1 No Yes 9 5 1 0
E:E:D114 E:E:E113 5.2 1 Yes Yes 9 9 2 1
E:E:E113 L:L:R95 5.82 1 Yes No 9 7 1 0
E:E:E113 L:L:R97 3.49 1 Yes Yes 9 5 1 0
E:E:D114 E:E:Y116 13.79 1 Yes No 9 9 2 1
E:E:Y116 L:L:R65 10.29 0 No No 9 9 1 0
E:E:D157 E:E:K125 13.83 0 No Yes 9 9 2 1
E:E:K125 E:E:M192 2.88 8 Yes No 9 9 1 1
E:E:K125 L:L:D49 6.91 8 Yes No 9 6 1 0
E:E:K125 L:L:N50 9.79 8 Yes Yes 9 9 1 0
E:E:E127 L:L:S47 7.19 8 No No 9 9 1 0
E:E:E127 L:L:N50 6.57 8 No Yes 9 9 1 0
E:E:E127 L:L:S53 5.75 8 No No 9 6 1 0
E:E:L131 L:L:S45 9.01 0 No No 9 5 1 0
E:E:M192 L:L:D49 15.25 8 No No 9 6 1 0
E:E:K197 E:E:N196 4.2 0 No No 9 9 2 1
E:E:N196 L:L:R69 4.82 0 No No 9 8 1 0
E:E:K199 L:L:G67 3.49 0 No No 9 8 1 0
E:E:A201 L:L:M68 3.22 0 No No 9 8 1 0
E:E:L131 E:E:Q128 2.66 0 No Yes 9 9 1 2
L:L:K58 R:R:H140 2.62 1 No No 8 8 0 1
E:E:G105 L:L:L63 1.71 0 No Yes 9 9 1 0
L:L:K41 R:R:M66 1.44 0 No No 6 9 0 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
85.00Single9KB9R-spondin-29KB9-LGR4; LGR4-R-spondin-2-ZNRF3; ZNRF3
76.19Single8XFPR-spondin-28XFP-LGR4-R-spondin-2-ZNRF3; ZNRF3
76.19Single9KB8R-spondin-29KB8-LGR4-R-spondin-2-ZNRF3; ZNRF3
72.73Single8Y69R-spondin-28Y69-LGR4; LGR4-R-spondin-2-ZNRF3
71.43Single8XFSR-spondin-28XFS-LGR4-R-spondin-2-ZNRF3; ZNRF3
71.43Single8Y69R-spondin-28Y69-LGR4; LGR4-R-spondin-2-ZNRF3
62.50Single8XFSR-spondin-28XFS-LGR4-R-spondin-2-ZNRF3; ZNRF3
61.90Single8XFPR-spondin-28XFP-LGR4-R-spondin-2-ZNRF3; ZNRF3
56.52Single8XFTR-spondin-28XFT-LGR4-R-spondin-2-ZNRF3
5.26Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
5.26Single6D35Cholesterol6D35-SMO-Cholesterol
5.26Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
5.26Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
5.26Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
5.26Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
5.26Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042
5.26Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042
5.26Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042
5.26Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-BHFF
5.26Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
5.26Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626
5.26Single7DD5Ca7DD5-CaS; CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.26Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS; CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.26Single7DD5Ca7DD5-CaS; CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.26Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS; CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.26Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
5.26Single7DTTCa7DTT-CaS; CaS-Ca-Ca
5.26Single7DTTCa7DTT-CaS; CaS-Ca-Ca
5.26Single7DTUTryptophan7DTU-CaS; CaS-Tryptophan
5.26Single7DTUTryptophan7DTU-CaS; CaS-Tryptophan
5.26Single7DTVCa7DTV-CaS; CaS-Ca-Ca; Tryptophan
5.26Single7DTVCa; Tryptophan7DTV-CaS; CaS-Ca-Ca; Tryptophan
5.26Single7DTVCa7DTV-CaS; CaS-Ca-Ca; Tryptophan
5.26Single7DTVCa; Tryptophan7DTV-CaS; CaS-Ca-Ca; Tryptophan
5.26Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.26Single7E6TCa7E6T-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.26Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.26Single7E6TCa7E6T-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.26Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
5.26Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
5.26Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
5.26Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
5.26Single7EB2Baclofen7EB2-GABAB2; GABAB1-Baclofen-rac-BHFF-Gi1/β1/γ2
5.26Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
5.26Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
5.26Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
5.26Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
5.26Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
5.26Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
5.26Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
5.26Single7FIIhCG7FII-LH-hCG-chim(NtGi1-Gs)/β1/γ2
5.26Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS; CaS-Ca; Ca; Tryptophan; NPS-2143
5.26Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS; CaS-Ca; Ca; Tryptophan; NPS-2143
5.26Single7M3FCa; Ca; Tryptophan; Cinacalcet7M3F-CaS; CaS-Ca; Ca; Tryptophan; Cinacalcet
5.26Single7M3FCa; Ca; Tryptophan; Cinacalcet7M3F-CaS; CaS-Ca; Ca; Tryptophan; Cinacalcet
5.26Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS; CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.26Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS; CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.26Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS; CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.26Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS; CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.26Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
5.26Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
5.26Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
5.26Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
5.26Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
5.26Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
5.26Single7SILCa7SIL-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4
5.26Single7SILCa; Ca; Ca; Cyclomethyltryptophan; R-568; PO47SIL-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4
5.26Single7SILCa7SIL-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4
5.26Single7SILCa; Ca; Ca; Cyclomethyltryptophan; R-568; PO47SIL-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4
5.26Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.26Single7SIMCa7SIM-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.26Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.26Single7SIMCa7SIM-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.26Single7T9NM22 Fab7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
5.26Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
5.26Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
5.26Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
5.26Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
5.26Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
5.26Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
5.26Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
5.26Single7XW7K1-707XW7-TSH-K1-70
5.26Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
5.26Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
5.26Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
5.26Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
5.26Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
5.26Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
5.26Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
5.26Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
5.26Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
5.26Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
5.26Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
5.26Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
5.26Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-NAM563
5.26Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
5.26Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
5.26Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
5.26Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
5.26Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
5.26Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
5.26Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
5.26Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
5.26Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
5.26Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
5.26Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
5.26Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
5.26Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS; CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
5.26Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS; CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
5.26Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS; CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
5.26Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
5.26Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
5.26Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
5.26Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
5.26Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
5.26Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
5.26Single8TQBCa; LY3792688TQB-mGlu3; mGlu3-Ca; LY379268-Ca
5.26Single8TQBCa; LY3792688TQB-mGlu3; mGlu3-Ca; LY379268-Ca
5.26Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
5.26Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
5.26Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
5.26Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
5.26Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
5.26Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
5.26Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
5.26Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
5.26Single8WG9PubChem 1793948WG9-mGlu4; mGlu2-PubChem 179394
5.26Single8WGBGlutamate8WGB-mGlu4; mGlu2-Glutamate-VU0155041-Gi3/β1/γ2
5.26Single8WGBGlutamate8WGB-mGlu4; mGlu2-Glutamate-VU0155041-Gi3/β1/γ2
5.26Single8WGCLY3792688WGC-mGlu2; mGlu4-LY379268
5.26Single8WGDLY341495; CPPG8WGD-mGlu4; mGlu2-LY341495; CPPG
5.26Single8WGDLY341495; CPPG8WGD-mGlu4; mGlu2-LY341495; CPPG
5.26Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS; CaS-Tryptophan; Cinacalcet; PO4; Ca
5.26Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS; CaS-Tryptophan; Cinacalcet; PO4; Ca
5.26Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS; CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.26Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS; CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.26Single8WVXNorrin8WVX-LGR4-Norrin
5.26Single8WVYNorrin8WVY-LGR4-Norrin
5.26Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
5.26Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
5.26Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
5.26Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
5.26Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
5.26Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
5.26Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
5.26Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
5.26Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU29
5.26Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU29
5.26Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
5.26Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
5.26Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
5.26Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
5.26Single8XUMR-spondin-28XUM-LGR4-R-spondin-2
5.26Single9ASBCa9ASB-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26Single9ASBCa; Ca; Cyclomethyltryptophan; R-568; PO49ASB-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26Single9AVGCa9AVG-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs)/β1/γ2
5.26Single9AVGCa; Ca; Cyclomethyltryptophan; R-568; PO49AVG-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs)/β1/γ2
5.26Single9AVLCa9AVL-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-Gi3/β2/γ2
5.26Single9AVLCa; Ca; Cyclomethyltryptophan; R-568; PO49AVL-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-Gi3/β2/γ2
5.26Single9AVLCa9AVL-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-Gi3/β2/γ2
5.26Single9AVLCa; Ca; Cyclomethyltryptophan; R-568; PO49AVL-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-Gi3/β2/γ2
5.26Single9AXFCa9AXF-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; R-568; PO49AXF-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26Single9AXFCa9AXF-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; R-568; PO49AXF-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26Single9AYFCa9AYF-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4-Gi1/β1/γ2
5.26Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; R-568; PO49AYF-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4-Gi1/β1/γ2
5.26Single9C1PCa9C1P-CaS; CaS-Ca-Ca; Tryptophan; '6218; PO4
5.26Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS; CaS-Ca-Ca; Tryptophan; '6218; PO4
5.26Single9C1PCa9C1P-CaS; CaS-Ca-Ca; Tryptophan; '6218; PO4
5.26Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS; CaS-Ca-Ca; Tryptophan; '6218; PO4
5.26Single9C2FCa9C2F-CaS; CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
5.26Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS; CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
5.26Single9C2FCa9C2F-CaS; CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
5.26Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS; CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
5.26Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2; Arrestin2
5.26Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2; Arrestin2
5.26Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
5.26Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
5.26Single9KB7R-spondin-29KB7-LGR4-R-spondin-2
5.26Single9KGKNB189KGK-LGR4-NB18
5.26Single9KHHNorrin9KHH-LGR4-Norrin
5.26Single9MBAGlutamate9MBA-mGlu8; mGlu8-Glutamate-Arrestin2 ; Arrestin2
5.26Single9MBAGlutamate9MBA-mGlu8; mGlu8-Glutamate-Arrestin2 ; Arrestin2
5.26Single9MBBLY3414959MBB-mGlu8; mGlu8-LY341495
5.26Single9MBBLY3414959MBB-mGlu8; mGlu8-LY341495
5.26Single9MBCDCPG9MBC-mGlu8; mGlu8-DCPG-AZ12216052
5.26Single9MBCDCPG9MBC-mGlu8; mGlu8-DCPG-AZ12216052
5.26Single9S37NB219S37-LGR4-NB21
5.26Single9S38NB219S38-LGR4-NB21
5.26Single9UTBSucralose9UTB-TAS1R2; TAS1R3-Sucralose
5.00Single7DD6Ca7DD6-CaS; CaS-Ca-Ca; Ca; Tryptophan
5.00Single7DD6Ca; Ca; Tryptophan7DD6-CaS; CaS-Ca-Ca; Ca; Tryptophan
5.00Single7DD6Ca7DD6-CaS; CaS-Ca-Ca; Ca; Tryptophan
5.00Single7DD6Ca; Ca; Tryptophan7DD6-CaS; CaS-Ca-Ca; Ca; Tryptophan
5.00Single7DD7Ca7DD7-CaS; CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS; CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.00Single7DD7Ca7DD7-CaS; CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS; CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS; CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
5.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS; CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
5.00Single9ASBCa9ASB-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single9ASBCa; Ca; Cyclomethyltryptophan; R-568; PO49ASB-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single9AVGCa9AVG-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs)/β1/γ2
5.00Single9AVGCa; Ca; Cyclomethyltryptophan; R-568; PO49AVG-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs)/β1/γ2
5.00Single9AYFCa9AYF-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4-Gi1/β1/γ2
5.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; R-568; PO49AYF-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4-Gi1/β1/γ2
4.76Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
4.76Single7T9MCS-17 Antibody7T9M-TSH-CS-17 Antibody
4.55Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
4.55Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/β1/γ2
4.55Single7UTZTSH7UTZ-TSH-TSH-DPPC-Gs/β1/γ2
4.55Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/β1/γ2
4.55Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
4.35Single5L7DCholesterol5L7D-SMO-Cholesterol
4.35Single7T9ITSH7T9I-TSH-TSH-Gs/β1/γ2
4.35Single8I2GFSH8I2G-FSH-FSH-PubChem 67530240-Gs/β1/γ2
4.35Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
4.35Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
4.17Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
4.17Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Gi1/β1/γ2
4.17Consensusp2y_offOrthosteric Ligandp2y1_off
4.00Single4XNWMRS25004XNW-P2Y1-MRS2500
4.00Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
4.00Single8JEFPubChem 113671668JEF-HCA3-PubChem 11367166-Gi1/β1/γ2
4.00Single8JPSCCL78JPS-ACKR1-CCL7
4.00Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
4.00Single9IJRC179IJR-GPR52-C17-Arrestin2
4.00Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
3.85Single4O9RCyclopamine4O9R-SMO-Cyclopamine
3.85Single6LI0C176LI0-GPR52-C17
3.85Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
3.85Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab
3.85Single9B9YTaranabant9B9Y-CB1-Taranabant
3.85Single9E7RGB889E7R-PAR2-GB88-chim(NtGi1L-Gs-CtGq)/β1/γ2
3.85Single9MNIdC2_059MNI-CTLike-dC2_05-RAMP1
3.70Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
3.70Single4BWBNeurotensin-(8-12)4BWB-NTS1-Neurotensin-(8-12)
3.70Single4QINSAG1.54QIN-SMO-SAG1.5
3.70Single5U09Taranabant5U09-CB1-Taranabant
3.70Single6LFOCXCL86LFO-CXCR2-CXCL8-Gi1/β1/γ2
3.70Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
3.70Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
3.70Single7BR3Elagolix7BR3-GnRH1-Elagolix
3.70Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
3.70Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
3.70Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
3.70Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
3.70Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
3.70Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
3.70Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
3.70Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
3.70Single8YNFCXCL88YNF-ACKR1-CXCL8
3.70Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
3.70Single9KO2CCL199KO2-CCR7-CCL19-Gi1/β1
3.70Single9KO6CCL199KO6-CCR7-CCL19
3.70Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
3.70Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
3.70Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-CXCL8-Gi1/β1/γ2
3.70Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
3.70Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
3.70Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
3.57Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
3.57Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
3.57Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
3.57Single7UTZDPPC7UTZ-TSH-TSH-DPPC-Gs/β1/γ2
3.57Single7VV6C48/807VV6-MRGPRX2-C48/80
3.57Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
3.57Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
3.57Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
3.57Single9BA0MRI-18919BA0-CB1-MRI-1891
3.57Single9K0KUTP9K0K-P2Y4-UTP-chim(NtGi1-Gs-CtGq)/β1/γ2
3.57Single9K0XATP9K0X-P2Y2-ATP-chim(NtGi1-Gs-CtGq)/β1/γ2
3.57Single9K20ATP9K20-P2Y2-ATP-chim(NtGi1-Go)/β1/γ2
3.57Single9M2FNeuropeptide-FF9M2F-NPFF1-Neuropeptide-FF-Gi1/β1/γ2
3.57Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
3.57Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-CXCL8-Gi1/β1/γ2
3.57Consensusgrh_offOrthosteric Ligandgnrh1_off
3.57Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
3.57Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
3.45Single4QIMANTA XV4QIM-SMO-ANTA XV
3.45Single5T04Neurotensin-(8-13)5T04-NTS1-Neurotensin-(8-13)
3.45Single5TGZAM65385TGZ-CB1-AM6538
3.45Single6D27CAY104716D27-DP2-CAY10471
3.45Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
3.45Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
3.45Single6Z4VNeurotensin-(9-13)6Z4V-NTS1-Neurotensin-(9-13)
3.45Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
3.45Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
3.45Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
3.45Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
3.45Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
3.45Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
3.45Single7VIFFTY720-P7VIF-S1P1-FTY720-P-Gi1/β1/γ2
3.45Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
3.45Single7YXAONO-54306087YXA-S1P5-ONO-5430608
3.45Single8IC0CXCL88IC0-CXCR1-CXCL8-Gi1/β1/γ2
3.45Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
3.45Single9METGp120; CD49MET-CXCR4-Gp120; CD4
3.45Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-CXCL8-Gi1/β1/γ2
3.45Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
3.45Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
3.45Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
3.33Single4JKVTaladegib4JKV-SMO-Taladegib
3.33Single5C1MBU725C1M-μ-BU72
3.33Single6LFMCXCL86LFM-CXCR2-CXCL8-Gi1/β1/γ2
3.33Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
3.33Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
3.33Single7C4SS1P7C4S-S1P3-S1P
3.33Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
3.33Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
3.33Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
3.33Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
3.33Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
3.33Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
3.33Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
3.33Single8ZYTNeurotensin-(8-13)8ZYT-NTS1-Neurotensin-(8-13)-SBI-553-Arrestin2
3.33Single9B9ZMRI-18679B9Z-CB1-MRI-1867
3.33Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
3.33Single9KO4CCL219KO4-CCR7-CCL21-Gi1/β1/γ2
3.33Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-CXCL8-Gi1/β1/γ2
3.33Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
3.33Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
3.33Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
3.33Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
3.23Single3ZEVNeurotensin-(7-13)3ZEV-NTS1-Neurotensin-(7-13)
3.23Single4BV0Neurotensin-(7-13)4BV0-NTS1-Neurotensin-(7-13)
3.23Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
3.23Single5V56TC1145V56-SMO-TC114
3.23Single5V57TC1145V57-SMO-TC114
3.23Single6OS1TRV0266OS1-AT1-TRV026
3.23Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
3.23Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
3.23Single7F1TCCL37F1T-CCR5-CCL3
3.23Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
3.23Single7L0PNeurotensin-(8-13)7L0P-NTS1-Neurotensin-(8-13)-Gi1/β1/γ1
3.23Single7L0QNeurotensin-(8-13)7L0Q-NTS1-Neurotensin-(8-13)-Gi1/β1/γ1
3.23Single7R0CAVP7R0C-V2-AVP-Arrestin2
3.23Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
3.23Single7T9NDPPC7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
3.23Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
3.23Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
3.23Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
3.23Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
3.23Single8FMZNeurotensin-(8-13)8FMZ-NTS1-Neurotensin-(8-13)-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.23Single8FN1Neurotensin-(8-13)8FN1-NTS1-Neurotensin-(8-13)-chim(NtGi1-Go)/β1/γ2
3.23Single8HQCC5a8HQC-C5a1-C5a-Go/β1/γ2
3.23Single8I2GPubChem 675302408I2G-FSH-FSH-PubChem 67530240-Gs/β1/γ2
3.23Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
3.23Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
3.23Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
3.23Single8JZPC5a8JZP-C5a1-C5a-Go/β1/γ2
3.23Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
3.23Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
3.23Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
3.23Single9IZGLPA9IZG-LPA1-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
3.23Single9JCLADP9JCL-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
3.23Single9L16CCL219L16-CCR7-CCL21
3.23Single9MENGp120 (V3 loop)9MEN-CXCR4-Gp120 (V3 loop)
3.23Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
3.23Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
3.23Consensuslpa_onOrthosteric Ligandlpa1_on
3.23Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
3.23Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
3.23Consensusneurotensin_onOrthosteric Ligandnts1_on
3.23Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-(8-13)-Gi1/β1/γ1
3.23Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
3.23Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
3.23Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
3.12Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
3.12Single4XEENeurotensin-(8-13)4XEE-NTS1-Neurotensin-(8-13)
3.12Single4XESNeurotensin-(8-13)4XES-NTS1-Neurotensin-(8-13)
3.12Single6OS0Angiotensin II6OS0-AT1-Angiotensin II
3.12Single6OS2TRV0266OS2-AT1-TRV026
3.12Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
3.12Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
3.12Single6YVRNeurotensin-(6-13)6YVR-NTS1-Neurotensin-(6-13)
3.12Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
3.12Single7EW2FTY720-P7EW2-S1P3-FTY720-P-Gi1/β1/γ2
3.12Single7L0SNeurotensin-(8-13)7L0S-NTS1-Neurotensin-(8-13)-Gi1/β1/γ1
3.12Single7W0NElabela7W0N-Apelin; Apelin-Elabela-Gi1/β1/γ2
3.12Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
3.12Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
3.12Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
3.12Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
3.12Single8T3QDoconexent8T3Q-FFA4-Doconexent-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.12Single8U26Substance-P8U26-NK1-Substance-P-Gs/β1/γ2
3.12Single8XQJJN2418XQJ-Apelin; Apelin-JN241
3.12Single8XWACXCL18XWA-CXCR2-CXCL1
3.12Single8XWMCXCL68XWM-CXCR2-CXCL6
3.12Single8XWSCXCL58XWS-CXCR2-CXCL5
3.12Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
3.12Single9ECJS-geranylgeranyl-L-glutathione9ECJ-P2Y8-S-geranylgeranyl-L-glutathione-G13/β1/γ2
3.12Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
3.12Single9VIFNeuropeptide-VF9VIF-NPFF1-Neuropeptide-VF-Gi1/β1/γ2
3.12Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
3.12Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
3.12Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
3.12Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
3.12Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-(8-13)-Gi1/β1/γ1
3.12Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
3.12Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
3.12Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
3.12Consensuslpa_offOrthosteric Ligandlpa1_off
3.12Consensuslpl_offOrthosteric Ligands1p_off lpa_off
3.12Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-C5-guano-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-DAMGO-Gi1/β1/γ2
3.12Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-C5-guano-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-DAMGO-Gi1/β1/γ2
3.12Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
3.12Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
3.12Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-(8-13)-Gi1/β1/γ1
3.12Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
3.12Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
3.12Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM-5541-Gi1/β1/γ2 7EW2-S1P3-FTY720-P-Gi1/β1/γ2
3.03Single4BUONeurotensin-(8-13)4BUO-NTS1-Neurotensin-(8-13)
3.03Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
3.03Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
3.03Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
3.03Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
3.03Single6UP7Neurotensin-(8-13)6UP7-NTS1-Neurotensin-(8-13)-Arrestin2
3.03Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
3.03Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
3.03Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
3.03Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
3.03Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
3.03Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
3.03Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
3.03Single8E0GBU728E0G-μ-BU72
3.03Single8FN0Neurotensin-(8-13)8FN0-NTS1-Neurotensin-(8-13)-SBI-553-chim(NtGi1-Go)/β1/γ2
3.03Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
3.03Single8JPFNeurotensin-(8-13)8JPF-NTS1-Neurotensin-(8-13)-SBI-553
3.03Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
3.03Single8XVUCXCL28XVU-CXCR2-CXCL2
3.03Single8XWFCXCL38XWF-CXCR2-CXCL3
3.03Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
3.03Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
3.03Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
3.03Single9C0KExendin-49C0K-GLP-1-Exendin-4-Gs/β1/γ2
3.03Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
3.03Single9IZFLPA9IZF-LPA1-LPA-Gi1/β1/γ2
3.03Single9KWXC5a-des-Arg9KWX-C5a1-C5a-des-Arg-Go/β1/γ2
3.03Single9UYMChemerin-99UYM-CML2-Chemerin-9-chim(Arrestin3-CtArrestin2)
3.03Single9WP9S1P9WP9-S1P3-S1P-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.03Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
3.03Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM-5541-Gi1/β1/γ2 7EW2-S1P3-FTY720-P-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
3.03Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
3.03Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
2.94Single5VBLAMG3054 5VBL-Apelin-AMG3054
2.94Single6KNMJN241-96KNM-Apelin-JN241-9
2.94Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
2.94Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
2.94Single7RKFCX3CL17RKF-US28-CX3CL1-GDP-chim(NtGi1-G11)/β1/γ2
2.94Single7RKNCX3CL17RKN-US28-CX3CL1-Gi1/β1/γ2
2.94Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
2.94Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
2.94Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
2.94Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
2.94Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
2.94Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
2.94Single8QJ2pN1628QJ2-MC4-pN162-Gs/β1/γ2
2.94Single8XQJJN2418XQJ-Apelin; Apelin-JN241
2.94Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
2.94Single9KX6C5a-des-Arg9KX6-C5a1-C5a-des-Arg-Go/β1/γ2
2.94Single9UMJEP549UMJ-C3aB-EP54-Go/β1/γ2
2.94Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
2.94Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
2.94Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
2.94Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
2.94Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
2.86Single4XT1CX3CL14XT1-US28-CX3CL1
2.86Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
2.86Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
2.86Single7L0RNeurotensin-(8-13)7L0R-NTS1-Neurotensin-(8-13)-Gi1/β1/γ1
2.86Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
2.86Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
2.86Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
2.86Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
2.86Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
2.86Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
2.86Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
2.86Single8U4OCXCL128U4O-CXCR4-CXCL12-Gi1/β1/γ2
2.86Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
2.86Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
2.86Single8XWNCXCL88XWN-CXCR2-CXCL8
2.86Single8YWFRetatrutide8YWF-GLP-1-Retatrutide-chim(NtGi1-Gs)/β1/γ2
2.86Single9BUECagrilintide9BUE-CT-Cagrilintide-Gs/β1/γ2
2.86Single9KWGC5a9KWG-C5a1-C5a-Go/β1/γ2
2.86Single9L3YChemerin9L3Y-CML2-Chemerin-Gi1/β1/γ2
2.86Single9MEJGp1209MEJ-CXCR4-Gp120
2.86Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
2.86Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
2.86Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
2.86Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
2.86Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
2.86Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-C5-guano-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-DAMGO-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
2.86Consensuslpl_onOrthosteric Ligands1p_on lpa_on
2.86Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
2.86Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
2.86Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
2.86Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
2.86Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
2.78Single6DO1(Sar1,Ile8)-Angiotensin II6DO1-AT1-(Sar1,Ile8)-Angiotensin II
2.78Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
2.78Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
2.78Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
2.78Single7F1QCCL37F1Q-CCR5-CCL3-Gi1/β1/γ2
2.78Single7PIVAfamelanotide7PIV-MC4-Afamelanotide-Gs/β1/γ2
2.78Single7RKMCX3CL17RKM-US28-CX3CL1-Gi1/β1/γ2
2.78Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
2.78Single7SK5CXCL127SK5-ACKR3-CXCL12
2.78Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
2.78Single7VBITirzepatide (non-acylated)7VBI-GLP-1-Tirzepatide (non-acylated)-Gs/β1/γ2
2.78Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
2.78Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
2.78Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
2.78Single8JZZC5a-des-Arg8JZZ-C5a1-C5a-des-Arg-Go/β1/γ2
2.78Single8Z7JJN241-98Z7J-Apelin-JN241-9-Gi1/β1/γ2
2.78Single9ME1CXCL129ME1-CXCR4-CXCL12
2.78Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
2.78Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
2.78Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
2.78Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM-5541-Gi1/β1/γ2 7EW2-S1P3-FTY720-P-Gi1/β1/γ2
2.78Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
2.70Single3OE0CVX153OE0-CXCR4-CVX15
2.70Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
2.70Single6MEOGp160; CD46MEO-CCR5-Gp160; CD4
2.70Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
2.70Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
2.70Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
2.70Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
2.70Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
2.70Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
2.70Single8K6NNeuropeptide-Y8K6N-Y2-Neuropeptide-Y-Gi2/β1/γ1
2.70Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
2.70Single8WVUR-spondin-18WVU-LGR4-R-spondin-1-RNF43
2.70Single8XZHMM078XZH-Apelin; Apelin-MM07-Gi1/β1/γ2
2.70Single8YFOAc-LA-PTH Analog8YFO-PTH1-Ac-LA-PTH Analog-chim(NtGi1-Gs)/β1/γ2
2.70Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
2.70Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
2.70Single9LXRLA-PTH Analog9LXR-PTH1-LA-PTH Analog-Arrestin2
2.70Single9M1ONeuropeptide-FF9M1O-NPFF2-Neuropeptide-FF-Gi1/β1/γ2
2.70Single9MEUCXCL129MEU-CXCR4-CXCL12
2.70Single9U4WGonadoliberin-19U4W-GnRH1-Gonadoliberin-1-chim(NtGi1L-Gs-CtGq)/β1/γ2
2.70Consensusangiotensin_onOrthosteric Ligandat1_on
2.70Consensusat1_onOrthosteric Ligand7F6G-AT1-(Sar1)-Angiotensin II-Gq/β1/γ2
2.70Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-C5a-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a-Gi1/β1/γ2
2.70Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
2.70Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
2.70Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
2.70Consensusclass-b1_class-b2_cons_onOrthosteric Ligandclass-b1_on class-b2_on
2.70Consensusclass-b1_class-b2_cons_on_gpOrthosteric Ligandclass-b1_on_gp class-b2_on_gp
2.70Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
2.70Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
2.70Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
2.70Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
2.63Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
2.63Single6M1IPACAP276M1I-PAC1-PACAP27-Gs/β1/γ2
2.63Single6METGp160; CD46MET-CCR5-Gp160; CD4
2.63Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
2.63Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
2.63Single7F6G(Sar1)-Angiotensin II7F6G-AT1-(Sar1)-Angiotensin II-Gq/β1/γ2
2.63Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
2.63Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
2.63Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
2.63Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
2.63Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
2.63Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
2.63Single8XZJWN3538XZJ-Apelin; Apelin-WN353-Gi1/β1/γ2
2.63Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
2.63Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ2
2.63Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
2.63Single9BLCCagrilintide (non-acylated)9BLC-CT-Cagrilintide (non-acylated)-Gs/β1/γ2
2.63Single9BUDCagrilintide9BUD-CT-Cagrilintide-Gs/β1/γ2
2.63Single9EBOGLP-1 (ACPC18)9EBO-GLP-1-GLP-1 (ACPC18)-Gs/β1/γ2
2.63Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
2.63Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-(Sar1)-Angiotensin II-Gq/β1/γ2
2.63Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-C5a-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a-Gi1/β1/γ2
2.63Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
2.63Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
2.63Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
2.63Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-(Sar1)-Angiotensin II-Gq/β1/γ2
2.63Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
2.63Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
2.63Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
2.63Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
2.63Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
2.63Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
2.63Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
2.63Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
2.63Consensusvasop-oxy_onOrthosteric Ligandv2_on
2.63Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
2.56Single5YQZNNC17025YQZ-Glucagon-NNC1702
2.56Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
2.56Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
2.56Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
2.56Single7F9YGhrelin7F9Y-Ghrelin-Ghrelin-chim(NtGi1-Gs-CtGq)/β1/γ2
2.56Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
2.56Single7P02Substance-P7P02-NK1-Substance-P-chim(NtGi1-Gs)/β1/γ2
2.56Single7TYHCalcitonin7TYH-CT (AMY2)-Calcitonin-Gs/β1/γ2; RAMP2
2.56Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
2.56Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
2.56Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
2.56Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
2.56Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
2.56Single7Y64C5a7Y64-C5a1-C5a-Gi1/β1/γ2
2.56Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
2.56Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
2.56Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
2.56Single8HK5C5a8HK5-C5a1-C5a-Gi1/β1/γ2
2.56Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
2.56Single8IA2C5a8IA2-C5a1-C5a-Go/β1/γ2
2.56Single8XQEApelin-138XQE-Apelin; Apelin-Apelin-13-Gi1/β1/γ2
2.56Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
2.56Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
2.56Single8YG4LA-PTH Analog8YG4-PTH1-LA-PTH Analog-chim(NtGi1-Gs)/β1/γ2
2.56Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGi1)/β1/γ2
2.56Single9E2AGLP-19E2A-GLP-1-GLP-1-Gs/β1/γ2
2.56Single9JFYNeuropeptide-SF9JFY-NPFF2-Neuropeptide-SF-Gi1/β1/γ2
2.56Consensuscalcitonin_onOrthosteric Ligandctlike_on
2.56Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
2.56Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
2.56Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
2.56Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
2.56Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
2.56Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
2.56Consensusgi_apelinOrthosteric Ligand8XZH-Apelin; Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin; Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin; Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin; Apelin-Apelin-13-Gi1/β1/γ2
2.56Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-CXCL8-Gi1/β1/γ2 6LFM-CXCR2-CXCL8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-CCL3-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
2.56Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
2.56Consensuspac_onOrthosteric Ligandpac1_on
2.56Consensusvpac1_onOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
2.56Consensusvpac_onOrthosteric Ligandvpac1_on vpac2_on
2.50Single4XT3CX3CL14XT3-US28-CX3CL1
2.50Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
2.50Single6FJ3PTH6FJ3-PTH1-PTH
2.50Single6NBFLA-PTH Analog6NBF-PTH1-LA-PTH Analog-Gs/β1/γ2
2.50Single6NBILA-PTH Analog6NBI-PTH1-LA-PTH Analog-Gs/β1/γ2
2.50Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
2.50Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
2.50Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
2.50Single7SK3CXCL127SK3-ACKR3-CXCL12
2.50Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
2.50Single7VABTirzepatide (non-acylated)7VAB-GIP-Tirzepatide (non-acylated)-chim(NtGi1-Gs)/β1/γ2
2.50Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
2.50Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
2.50Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
2.50Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
2.50Single9BLBCagrilintide (non-acylated)9BLB-CT-Cagrilintide (non-acylated)-Gs/β1/γ2
2.50Single9BLWCagrilintide (non-acylated)9BLW-CT (AMY1)-Cagrilintide (non-acylated)-Gs/β1/γ2; RAMP1
2.50Single9BP3Cagrilintide9BP3-CT (AMY1)-Cagrilintide-Gs/β1/γ2; RAMP1
2.50Single9BUBCagrilintide9BUB-CT-Cagrilintide-Gs/β1/γ2
2.50Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
2.50Single9P92VIP9P92-PAC1-VIP-Gs/β1/γ2
2.50Consensuscalcitonin_on_gpOrthosteric Ligandctlike_on_gp
2.50Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
2.50Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-CCL3-Gi1/β1/γ2
2.50Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
2.50Consensuscrf2_on_gpOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
2.50Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
2.50Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-C5a-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a-Gi1/β1/γ2 7Y64-C5a1-C5a-Gi1/β1/γ2
2.50Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
2.50Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
2.50Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
2.50Consensuspac1_onOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
2.50Consensuspac1_on_gpOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
2.50Consensuspac_on_gpOrthosteric Ligandpac1_on_gp
2.50Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
2.50Consensusvpac1_on_gpOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
2.50Consensusvpac_on_gpOrthosteric Ligandvpac1_on_gp vpac2_on_gp
2.44Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
2.44Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
2.44Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
2.44Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
2.44Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
2.44Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
2.44Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
2.44Single7S1MExendin-4-D-Ala7S1M-GLP-1-Exendin-4-D-Ala-Gs/β1/γ2
2.44Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
2.44Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
2.44Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
2.44Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
2.44Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
2.44Single8FU6ZP37808FU6-Glucagon-ZP3780-Gs/β1/γ2
2.44Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
2.44Single8ZH8QRFP268ZH8-QRFP-QRFP26-Gq/β1/γ1
2.44Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
2.44Single9BUCCagrilintide9BUC-CT-Cagrilintide-Gs/β1/γ2
2.44Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
2.44Single9P94PACAP279P94-PAC1-PACAP27-Gs/β1/γ2
2.44Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
2.44Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
2.44Consensusglp2_on_gpOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
2.44Consensusglp_onOrthosteric Ligandglp1_on glp2_on
2.44Consensusglp_on_gpOrthosteric Ligandglp1_on_gp glp2_on_gp
2.44Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
2.44Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
2.44Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
2.44Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
2.44Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
2.38Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
2.38Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
2.38Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
2.38Single6NBHLA-PTH Analog6NBH-PTH1-LA-PTH Analog-Gs/β1/γ2
2.38Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
2.38Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
2.38Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
2.38Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
2.38Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
2.38Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
2.38Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
2.38Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
2.38Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
2.38Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
2.38Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
2.38Single8IY6Endothelin-18IY6-ETB-Endothelin-1
2.38Single9BQ3Cagrilintide9BQ3-CT (AMY2)-Cagrilintide-Gs/β1/γ2; RAMP2
2.38Single9BTWCagrilintide9BTW-CT (AMY3)-Cagrilintide-Gs/β1/γ2; RAMP3
2.38Single9BYOExendin-39BYO-GLP-1-Exendin-3-Gs/β1/γ2
2.38Single9P93VIP9P93-PAC1-VIP-Gs/β1/γ2
2.38Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
2.38Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
2.38Consensusbradykinin_onOrthosteric Ligandbk2_on
2.38Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
2.38Consensusctlike_on_gpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
2.38Consensusendothelin_onOrthosteric Ligandetb_on eta_on
2.38Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
2.38Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
2.38Consensuspth1_onOrthosteric Ligand6NBF-PTH1-LA-PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-PTH-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
2.38Consensusvip-pacap_onOrthosteric Ligandvpac_on pac_on
2.38Consensusvip-pacap_on_gpOrthosteric Ligandvpac_on_gp pac_on_gp
2.38Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
2.38Consensusvpac2_on_gpOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
2.33Single5GLHEndothelin-15GLH-ETB-Endothelin-1
2.33Single6IGKEndothelin-36IGK-ETB-Endothelin-3
2.33Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
2.33Single7RBTTirzepatide7RBT-GIP-Tirzepatide-LSN3556672-chim(NtGi1-Gs)/β1/γ2
2.33Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
2.33Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
2.33Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-CCL3-Gi1/β1/γ2
2.33Consensusclass-a_class-b1_cons_onOrthosteric Ligandclass-a_on class-b1_on
2.33Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
2.33Consensusgip_onOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
2.33Consensusgip_on_gpOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
2.33Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
2.33Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
2.27Single6LPBPACAP276LPB-PAC1-PACAP27-Gs/β1/γ1
2.27Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
2.27Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
2.27Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
2.27Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
2.27Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
2.27Single8FLULA-PTH Analog8FLU-PTH1-LA-PTH Analog-Gs/β1/γ2
2.27Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
2.27Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
2.27Consensusglp1_onOrthosteric Ligand7S1M-GLP-1-Exendin-4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Tirzepatide (non-acylated)-Gs/β1/γ2
2.27Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
2.27Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
2.22Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
2.22Single6WPWZP37806WPW-Glucagon-ZP3780-Gs/β1/γ2
2.22Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
2.22Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
2.22Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
2.22Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
2.22Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
2.22Consensuscrf_on_gpOrthosteric Ligandcrf2_on_gp crf1_on_gp
2.22Consensusglp1_on_gpOrthosteric Ligand7S1M-GLP-1-Exendin-4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Tirzepatide (non-acylated)-Gs/β1/γ2
2.22Consensuspth1_on_gpOrthosteric Ligand6NBF-PTH1-LA-PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-PTH-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
2.17Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
2.17Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
2.17Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
2.17Single7Y36PTH7Y36-PTH1-PTH-Gs/β1/γ2
2.17Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
2.17Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
2.17Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
2.17Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
2.17Consensusclass-a_class-b1_cons_on_gpOrthosteric Ligandclass-a_on_gp class-b1_on_gp
2.17Consensusglucagon_onOrthosteric Ligandglp_on gluc_on secretin_on gip_on
2.17Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
2.13Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
2.13Consensusgluc_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
2.13Consensusglucagon_on_gpOrthosteric Ligandglp_on_gp gluc_on_gp secretin_on_gp gip_on_gp
2.13Consensuspth_onOrthosteric Ligandpth1_on pth2_on
2.08Consensusgluc_on_gpOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
2.08Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
2.08Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
2.04Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
2.04Consensusclass-b1_onOrthosteric Ligandglucagon_on vip-pacap_on pth_on crf_on calcitonin_on
2.04Consensuspth2_on_gpOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
2.00Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
1.96Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
1.96Consensuspth_on_gpOrthosteric Ligandpth1_on_gp pth2_on_gp
1.89Consensusclass-b1_on_gpOrthosteric Ligandglucagon_on_gp vip-pacap_on_gp pth_on_gp crf_on_gp calcitonin_on_gp
1.85Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1

PDB Summary
PDB 9KB9
Class A
SubFamily Orphan
Type Orphan
SubType LGR4; LGR4
Species Homo sapiens
Ligand R-spondin-2
Other Ligand(s) -
Protein Partners ZNRF3; ZNRF3
PDB Resolution 3.59
Date 2025-10-15
D.O.I. doi.org/10.1038/s41467-025-64129-z
Net Summary
Imin 2.77
Number of Linked Nodes 2020
Number of Links 2390
Number of Hubs 357
Number of Links mediated by Hubs 1280
Number of Communities 77
Number of Nodes involved in Communities 523
Number of Links involved in Communities 690
Path Summary
Number Of Nodes in MetaPath 327
Number Of Links MetaPath 326
Number of Shortest Paths 79948511
Length Of Smallest Path 3
Average Path Length 156.073
Length of Longest Path 137
Minimum Path Strength 1.39
Average Path Strength 8.04
Maximum Path Strength 26.085
Minimum Path Correlation 0.82
Average Path Correlation 1
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 3.07692
Average % Of Corr. Nodes 66.2186
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 68.0581
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process• multicellular organismal process   • tissue remodeling   • bone remodeling   • developmental process   • epithelium development   • cell population proliferation   • tube development   • morphogenesis of an epithelium   • tissue development   • renal system development   • epithelial cell proliferation involved in renal tubule morphogenesis   • tissue morphogenesis   • anatomical structure morphogenesis   • multicellular organism development   • tube morphogenesis   • anatomical structure development   • renal tubule development   • cellular process   • epithelial tube morphogenesis   • epithelial cell proliferation   • renal tubule morphogenesis   • system development   • cellular developmental process   • ossification   • cell differentiation   • osteoblast differentiation   • cellular response to stimulus   • positive regulation of response to biotic stimulus   • regulation of cellular process   • pattern recognition receptor signaling pathway   • response to stimulus   • toll-like receptor signaling pathway   • negative regulation of biological process   • regulation of signal transduction   • response to biotic stimulus   • cell communication   • immune response-activating signaling pathway   • positive regulation of immune response   • regulation of immune system process   • signal transduction   • positive regulation of immune system process   • innate immune response-activating signaling pathway   • regulation of biological process   • immune response   • response to other organism   • regulation of innate immune response   • response to external stimulus   • regulation of response to stimulus   • defense response to other organism   • regulation of pattern recognition receptor signaling pathway   • positive regulation of defense response   • activation of innate immune response   • regulation of immune response   • regulation of toll-like receptor signaling pathway   • activation of immune response   • regulation of defense response   • regulation of response to biotic stimulus   • biological process involved in interspecies interaction between organisms   • regulation of response to external stimulus   • signaling   • negative regulation of signaling   • positive regulation of biological process   • negative regulation of cell communication   • positive regulation of response to stimulus   • positive regulation of response to external stimulus   • immune response-regulating signaling pathway   • regulation of response to stress   • response to stress   • innate immune response   • negative regulation of cellular process   • response to external biotic stimulus   • regulation of signaling   • positive regulation of innate immune response   • defense response   • negative regulation of response to stimulus   • biological regulation   • defense response to symbiont   • negative regulation of signal transduction   • negative regulation of toll-like receptor signaling pathway   • negative regulation of immune system process   • immune system process   • regulation of cell communication   • spermatogenesis   • sexual reproduction   • reproductive process   • multicellular organismal reproductive process   • developmental process involved in reproduction   • male gamete generation   • gamete generation   • bone mineralization   • animal organ development   • biomineral tissue development   • mesonephric epithelium development   • kidney epithelium development   • branching morphogenesis of an epithelial tube   • nephron tubule morphogenesis   • regulation of kidney development   • regulation of branching involved in ureteric bud morphogenesis   • positive regulation of developmental process   • animal organ morphogenesis   • nephron development   • regulation of morphogenesis of a branching structure   • regulation of animal organ morphogenesis   • positive regulation of multicellular organismal process   • mesonephric tubule development   • regulation of developmental process   • nephron morphogenesis   • nephron epithelium morphogenesis   • nephron tubule development   • ureteric bud morphogenesis   • positive regulation of morphogenesis of an epithelium   • branching involved in ureteric bud morphogenesis   • regulation of morphogenesis of an epithelium   • regulation of multicellular organismal process   • regulation of anatomical structure morphogenesis   • nephron epithelium development   • ureteric bud development   • mesonephros development   • kidney morphogenesis   • morphogenesis of a branching structure   • positive regulation of branching involved in ureteric bud morphogenesis   • mesonephric tubule morphogenesis   • kidney development   • morphogenesis of a branching epithelium   • digestive system development   • digestive tract development   • epidermis development   • molting cycle process   • hair cycle   • skin development   • skin epidermis development   • hair follicle development   • molting cycle   • hair cycle process   • genitalia development   • reproductive system development   • sex differentiation   • male sex differentiation   • male genitalia development   • reproductive structure development   • multicellular organismal-level homeostasis   • homeostatic process   • homeostasis of number of cells   • intestinal stem cell homeostasis   • regulation of biosynthetic process   • rhythmic process   • circadian regulation of gene expression   • circadian rhythm   • regulation of macromolecule metabolic process   • gene expression   • macromolecule biosynthetic process   • regulation of gene expression   • biosynthetic process   • regulation of macromolecule biosynthetic process   • metabolic process   • macromolecule metabolic process   • regulation of metabolic process   • cytokine production   • regulation of cytokine production   • negative regulation of macromolecule metabolic process   • negative regulation of metabolic process   • negative regulation of cytokine production   • negative regulation of gene expression   • negative regulation of biosynthetic process   • negative regulation of macromolecule biosynthetic process   • negative regulation of multicellular organismal process   • metanephric tubule morphogenesis   • metanephric epithelium development   • metanephros development   • metanephros morphogenesis   • metanephric nephron tubule morphogenesis   • metanephric nephron development   • metanephric nephron epithelium development   • metanephric nephron tubule development   • metanephric nephron morphogenesis   • metanephric tubule development   • cell surface receptor signaling pathway   • Wnt signaling pathway   • positive regulation of cell communication   • positive regulation of signal transduction   • regulation of canonical Wnt signaling pathway   • canonical Wnt signaling pathway   • positive regulation of Wnt signaling pathway   • positive regulation of cellular process   • positive regulation of canonical Wnt signaling pathway   • regulation of Wnt signaling pathway   • positive regulation of signaling   • negative regulation of cold-induced thermogenesis   • adaptive thermogenesis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • metanephric glomerulus development   • glomerulus development   • cell periphery   • cellular anatomical structure   • plasma membrane   • membrane   • protein binding   • binding   • signaling receptor binding   • BMP receptor binding   • receptor serine/threonine kinase binding   • transmembrane receptor protein serine/threonine kinase binding   • heparin binding   • glycosaminoglycan binding   • carbohydrate derivative binding   • sulfur compound binding   • regulation of odontogenesis of dentin-containing tooth   • negative regulation of developmental process   • regulation of odontogenesis   • odontogenesis of dentin-containing tooth   • odontogenesis   • negative regulation of odontogenesis   • negative regulation of odontogenesis of dentin-containing tooth   • negative regulation of animal organ morphogenesis   • lung growth   • developmental growth   • growth   • respiratory tube development   • organ growth   • lung development   • respiratory system development   • trachea cartilage morphogenesis   • connective tissue development   • trachea cartilage development   • trachea morphogenesis   • skeletal system development   • trachea development   • cartilage morphogenesis   • cartilage development   • limb development   • appendage development   • embryonic forelimb morphogenesis   • embryonic limb morphogenesis   • embryonic morphogenesis   • embryonic appendage morphogenesis   • embryo development   • forelimb morphogenesis   • appendage morphogenesis   • limb morphogenesis   • lung morphogenesis   • epithelial tube branching involved in lung morphogenesis   • embryonic hindlimb morphogenesis   • hindlimb morphogenesis   • dopaminergic neuron differentiation   • nervous system development   • generation of neurons   • neurogenesis   • neuron differentiation   • cell surface   • extracellular region   • extracellular space   • aminoacyltransferase activity   • ubiquitin-like protein transferase activity   • catalytic activity, acting on a protein   • acyltransferase activity   • transferase activity   • catalytic activity   • ubiquitin-protein transferase activity   • cation binding   • transition metal ion binding   • zinc ion binding   • ion binding   • metal ion binding   • small molecule binding   • ubiquitin-like protein ligase activity   • ubiquitin protein ligase activity   • G protein-coupled receptor binding   • frizzled binding   • catabolic process   • primary metabolic process   • protein catabolic process   • macromolecule catabolic process   • modification-dependent macromolecule catabolic process   • modification-dependent protein catabolic process   • ubiquitin-dependent protein catabolic process   • protein metabolic process   • stem cell proliferation   • regulation of Wnt signaling pathway, planar cell polarity pathway   • Wnt signaling pathway, planar cell polarity pathway   • regulation of non-canonical Wnt signaling pathway   • non-canonical Wnt signaling pathway   • receptor catabolic process   • negative regulation of Wnt signaling pathway   • receptor metabolic process   • Wnt receptor catabolic process   • negative regulation of canonical Wnt signaling pathway   • protein ubiquitination   • macromolecule modification   • post-translational protein modification   • protein modification process   • protein modification by small protein conjugation   • protein modification by small protein conjugation or removal   • negative regulation of non-canonical Wnt signaling pathway
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeNAG
PDB ResiduesH:H:?1 H:H:?2 H:H:?3 H:H:?4
Environment DetailsOpen EMBL-EBI Page
CodeNAG
NameN-Acetylglucosamine
SynonymsN-Acetylchitosamine
Identifier
FormulaC8 H15 N O6
Molecular Weight221.208
SMILES
PubChem24139
Formal Charge0
Total Atoms30
Total Chiral Atoms5
Total Bonds30
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ9BXB1
Sequence
>9KB9_Chain_R
CAAPCSCDG DRRVDCSGK GLTAVPEGL SAFTQALDI SMNNITQLP 
EDAFKNFPF LEELQLAGN DLSFIHPKA LSGLKELKV LTLQNNQLK 
TVPSEAIRG LSALQSLRL DANHITSVP EDSFEGLVQ LRHLWLDDN 
SLTEVPVHP LSNLPTLQA LTLALNKIS SIPDFAFTN LSSLVVLHL 
HNNKIRSLS QHCFDGLDN LETLDLNYN NLGEFPQAI KALPSLKEL 
GFHSNSISV IPDGAFDGN PLLRTIHLY DNPLSFVGN SAFHNLSDL 
HSLVIRGAS MVQQFPNLT GTVHLESLT LTGTKISSI PNNLCQEQK 
MLRTLDLSY NNIRDLPSF NGCHALEEI SLQRNQIYQ IKEGTFQGL 
ISLRILDLS RNLIHEIHS RAFATLGPI TNLDVSFNE LTSFPTEGL 
NGLNQLKLV GNFKLKEAL AAKDFVNLR SLSVPYAYQ CCAFIHCTP 
STGAFKPCE YLLGSWMIR LTVWFIFLV ALFFNLLVI LTTFASCTS 
LPSSKLFIG LISVSNLFM GIYTGILTF LDAVSWGRF AEFGIWWET 
GSGCKVAGF LAVFSSESA IFLLMLATV ERSLSAKDI MKNGKSNHL 
KQFRVAALL AFLGATVAG CFPLFHRGE YSASPLCLP FPTGETPSL 
GFTVTLVLL NSLAFLLMA VIYTKLYCN LEKEDLSEN SQSSMIKHV 
AWLIFTNCI FFCPVAFFS FAPLITAIS ISPEIMKSV TLIFFPLPA 
CLNPVLYVF FNPKFKEDW KLLKRRVTK K


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainS
ProteinReceptor
UniProtQ9BXB1
Sequence
>9KB9_Chain_S
CAAPCSCDG DRRVDCSGK GLTAVPEGL SAFTQALDI SMNNITQLP 
EDAFKNFPF LEELQLAGN DLSFIHPKA LSGLKELKV LTLQNNQLK 
TVPSEAIRG LSALQSLRL DANHITSVP EDSFEGLVQ LRHLWLDDN 
SLTEVPVHP LSNLPTLQA LTLALNKIS SIPDFAFTN LSSLVVLHL 
HNNKIRSLS QHCFDGLDN LETLDLNYN NLGEFPQAI KALPSLKEL 
GFHSNSISV IPDGAFDGN PLLRTIHLY DNPLSFVGN SAFHNLSDL 
HSLVIRGAS MVQQFPNLT GTVHLESLT LTGTKISSI PNNLCQEQK 
MLRTLDLSY NNIRDLPSF NGCHALEEI SLQRNQIYQ IKEGTFQGL 
ISLRILDLS RNLIHEIHS RAFATLGPI TNLDVSFNE LTSFPTEGL 
NGLNQLKLV GNFKLKEAL AAKDFVNLR SLSVPYAYQ CCAFIHCTP 
STGAFKPCE YLLGSWMIR LTVWFIFLV ALFFNLLVI LTTFASCTS 
LPSSKLFIG LISVSNLFM GIYTGILTF LDAVSWGRF AEFGIWWET 
GSGCKVAGF LAVFSSESA IFLLMLATV ERSLSAKDI MKNGKSNHL 
KQFRVAALL AFLGATVAG CFPLFHRGE YSASPLCLP FPTGETPSL 
GFTVTLVLL NSLAFLLMA VIYTKLYCN LEKEDLSEN SQSSMIKHV 
AWLIFTNCI FFCPVAFFS FAPLITAIS ISPEIMKSV TLIFFPLPA 
CLNPVLYVF FNPKFKEDW KLLKRRVTK K


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9KB6AOrphanOrphanLGR4Homo sapiens---3.532025-10-15doi.org/10.1038/s41467-025-64129-z
9KB7AOrphanOrphanLGR4Homo sapiensR-spondin-2--3.972025-10-15doi.org/10.1038/s41467-025-64129-z
9KB8AOrphanOrphanLGR4Homo sapiensR-spondin-2-ZNRF3; ZNRF33.252025-10-15doi.org/10.1038/s41467-025-64129-z
9KB9AOrphanOrphanLGR4; LGR4Homo sapiensR-spondin-2-ZNRF3; ZNRF33.592025-10-15doi.org/10.1038/s41467-025-64129-z
8WVUAOrphanOrphanLGR4Homo sapiensR-spondin-1-RNF433.612024-10-30To be published
8WVVAOrphanOrphanLGR4Homo sapiens---3.352024-10-30To be published
8WVWAOrphanOrphanLGR4Homo sapiens---3.532024-10-30To be published
8WVXAOrphanOrphanLGR4Homo sapiensNorrin--3.322024-10-30To be published
8WVYAOrphanOrphanLGR4Homo sapiensNorrin--3.292024-10-30To be published
8XFPAOrphanOrphanLGR4Homo sapiensR-spondin-2-ZNRF3; ZNRF33.212024-12-04doi.org/10.1038/s41467-024-55431-3
8XFSAOrphanOrphanLGR4Homo sapiensR-spondin-2-ZNRF3; ZNRF33.22024-12-04doi.org/10.1038/s41467-024-55431-3
8XFTAOrphanOrphanLGR4Homo sapiensR-spondin-2-ZNRF33.242024-12-04doi.org/10.1038/s41467-024-55431-3
8Y69AOrphanOrphanLGR4; LGR4Homo sapiensR-spondin-2-ZNRF33.382024-12-04doi.org/10.1038/s41467-024-55431-3
8XT9AOrphanOrphanLGR4Homo sapiens---3.12025-01-15doi.org/10.1016/j.molcel.2025.01.024
8XUMAOrphanOrphanLGR4Homo sapiensR-spondin-2--2.92025-01-15doi.org/10.1016/j.molcel.2025.01.024
9KGKAOrphanOrphanLGR4Homo sapiensNB18--2.632025-07-16To be published
9KHHAOrphanOrphanLGR4Homo sapiensNorrin--3.652025-07-16To be published
9S37AOrphanOrphanLGR4Homo sapiensNB21--3.942025-07-30To be published
9S38AOrphanOrphanLGR4Homo sapiensNB21--3.942025-09-03To be published




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9KB9.zip



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