Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
1G.HN.36 5.473754134
2G.S1.02 6.36875446
3G.H1.01 5.1154189
4G.S3.03 7.036508
5G.S3.06 12.49754167
6G.H2.01 5.525409
7G.H2.06 6.1925639
8G.H2.07 4.67333639
9G.h2s4.01 10.2062409
10G.s4h3.15 4.1875409
11G.H3.09 4.816676209
12G.H3.13 8.6235206
13G.H3.17 12.241565
14G.S5.05 5.66256199
15G.S5.07 5.615409
16G.s5hg.01 3.85409
17G.hgh4.08 7.85875456
18G.hgh4.11 4.073555
19G.hgh4.20 7.96375403
20G.H4.03 3.31125404
21G.H4.07 9.83375455
22G.H4.08 5.925753
23G.H4.10 10.773507
24G.H4.12 5.88917654
25G.H4.15 8.6825408
26G.h4s6.12 6.62875402
27G.h4s6.20 7.6404
28G.S6.02 9.245408
29G.S6.05 8.409555
30G.H5.05 5.805445
31G.H5.08 5.8025648
32G.H5.17 9.725445
33G.H5.19 6.9448
34G.H5.20 4.4975408
35b.1x3 2.272508
36b.lhb1x3 3.472582
37b.lhb1x6 5.04375483
38b.l1x3 10.2475149
39b.l1x6 9.361569
40b.b2x5 6.17667607
41b.l3x1 7.6469
42b.l3x2 7.735409
43b.b4x5 5.718754237
44b.b4x6 10.54086149
45b.b4x7 7.943754138
46b.l4x3 5.40254136
47b.b5x2 9.6354137
48b.b5x3 6.44509
49b.l5x1 5.33408
50b.l5x5 8.935609
51b.b6x1 5.45409
52b.b7x1 5.4504
53b.l7x4 3.83409
54b.b8x3 3.40125406
55b.b8x4 5.901506
56b.l8x3 2.8575403
57b.l9x3 6.46167639
58b.l9x6 5.69062838
59b.b10x5 4.86417609
60b.l10x1 3.86375403
61b.b11x1 4.95875405
62b.b11x4 5.68439
63b.b12x6 8.99833638
64b.b13x3 8.58375434
65b.b13x7 10.1388477
66b.l13x3 9.049579
67b.l13x6 7.535439
68b.b14x3 4.15875475
69b.b15x1 8.86479
70b.b15x2 8.58125426
71b.l15x1 5.36875437
72b.l15x2 6.43625479
73b.b16x4 12.32476
74b.b16x5 5.73375425
75b.b16x6 10.298578
76b.b16x7 8.156254249
77b.b17x5 7.073527
78b.b17x7 9.59428
79b.l17x3 9.45583629
80b.l17x6 8.39375439
81b.l17x7 4.24875427
82b.b18x3 4.855528
83b.l18x1 6.127867116
84b.l18x2 6.023754117
85b.b19x2 9.66875426
86b.b19x4 5.83875428
87b.l19x1 7.35439
88b.l19x2 8.138529
89b.b20x2 6.545426
90b.b20x4 10.1192628
91b.b20x6 7.658526
92b.b21x1 7.1575627
93b.b21x7 6.46167605
94b.b22x5 5.5875117
95b.l22x5 7.157589
96b.b23x1 4.7225405
97b.b23x6 7.776676157
98b.l23x1 6.146566
99b.b24x6 8.3954158
100b.b24x7 6.80125489
101b.l24x2 6.01625486
102b.l25x3 8.4595109
103b.l25x6 14.8662468
104b.l26x1 6.614227
105b.l27x1 11.29669
106b.l27x2 7.748754109
107b.b28x4 7.436254106
108b.b28x6 8.540836109
109g.h1x11 3.47625409
110g.l1x4 3.08417628
111g.l1x6 4.6404
112g.h2x11 8.754116
113g.ctx3 6.3525609
114g.ctx6 4.04917686
115g.ctx14 4.85375409
116g.ctx15 7.691254129
117g.ctx16 5.905717128
118Lig 19.33152410
119NT 180.175615
1201x36 4.4475415
1211x38 2.07125406
1221x39 6.68917618
1231x43 7.356518
1241x50 4.5125419
1251x60 6.44375406
1262x39 6.9754219
1272x40 4.688754219
1282x50 9.138518
1292x51 3.6025406
1302x53 7.992518
1312x60 8.4775417
1322x64 5.05125417
133E1 20.3086714
1343x32 5.97407
1353x37 4.567515
1363x40 8.7175418
1373x41 7.1475415
1383x42 10.9625259
1393x46 9.1525409
1403x49 7.11583608
1413x50 6.56625499
1423x51 5.485408
1433x54 5.43125498
144I2 6.09944946
1454x46 4.727507
1464x50 7.938754258
1474x60 7.936518
148E2 8.50722915
149E2x51 12.161519
150E2x52 5.171515
1515x37 3.79375413
1525x41 8.2575417
1535x43 6.12625417
1545x58 6.225599
1555x68 7.62625449
156I3 6.81833655
1576x44 5.30417699
1586x47 7.47375418
1596x48 9.282518
1606x49 5.69375405
1616x51 6.323506
162E3 6.87833614
1637x33 6.93875418
1647x45 6.186519
1657x54 3.98625409
166b.l11x2 4.56430
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1b.l1x4 b.l3x2 14.861112.89NoYes069
2G.hns1.01 b.l1x4 15.16745.275NoNo046
35x68 G.H5.16 10.639911.525YesNo496
4G.H5.17 G.H5.26 35.24213.645YesNo058
5G.H5.20 G.H5.26 35.45694.15YesNo088
65x65 G.H5.20 49.08263.46NoYes088
75x65 6x33 49.22383.46NoNo088
85x66 6x33 94.0373.46NoNo058
95x66 I3 94.70063.905NoYes555
10G.H4.12 I3 49.43154.26YesYes545
11G.H4.12 G.S6.03 52.28325.04YesNo545
12G.S5.04 G.S6.03 97.80344.105NoNo095
13G.H4.15 G.S5.04 1008.525YesNo089
14G.H3.09 G.H4.15 99.8398.035YesYes098
15G.H3.09 G.S4.04 63.27853.755YesNo099
16G.S1.07 G.S4.04 14.74233.655NoNo089
17G.S1.05 G.S1.07 14.15164.15NoNo1798
18G.S1.05 G.h2s4.01 14.475520.705NoYes099
19G.h2s4.01 b.l5x5 14.524311.025YesYes099
20G.S3.06 b.l5x5 17.378823.55YesYes079
21G.S1.03 G.S3.06 16.55054.275NoYes097
22G.S1.03 G.hns1.01 15.707618.005NoNo094
233x49 G.H5.23 10.5693.97YesNo084
243x50 G.H5.23 20.73829.965YesNo094
253x50 3x54 11.14016.225YesYes998
263x54 G.H5.20 15.75596.225YesYes088
273x50 6x44 10.64563.65YesYes999
285x58 6x44 43.90326.965YesYes999
295x58 5x62 44.39739.42YesNo997
305x62 6x33 44.80463.57NoNo078
31G.H4.16 I3 45.52574.855NoYes545
32G.H4.16 G.S6.03 45.56074.105NoNo545
33G.H3.09 G.H3.13 36.92784.01YesYes2096
34G.H3.13 G.h4s6.13 36.381323.8YesNo067
35G.h4s6.12 G.h4s6.13 36.22874.515YesNo027
36G.h3s5.01 G.h4s6.12 35.94065.33NoYes032
37G.H3.16 G.h3s5.01 35.88923.71NoNo053
38G.H3.16 G.H3.17 35.839220.31NoYes055
39G.H3.17 b.l27x1 31.72118.435YesYes659
40b.b26x1 b.l27x1 37.98493.705NoYes099
41b.b26x1 b.b26x2 37.81263.44NoNo097
42b.b26x2 b.b2x3 37.46854.86NoNo076
43b.b2x3 b.b2x5 37.29674.655NoYes067
44G.S4.05 G.s1h1.05 14.79464.04NoNo079
45G.H1.01 G.s1h1.05 12.82523.06YesNo099
46G.H5.17 G.h4s6.20 13.885516.465YesYes054
47G.S6.02 G.h4s6.20 13.46294.96YesYes084
48G.H5.10 G.S6.02 27.509913.79NoYes078
49G.H5.10 G.S5.03 12.860612.59NoNo079
50G.S5.03 G.S5.05 11.97423.77NoYes099
51G.S4.05 G.S5.05 15.95993.275NoYes079
52G.H5.13 G.H5.17 12.83610.125NoYes485
53G.H5.13 G.S6.02 15.36669.77NoYes088
54G.H5.10 G.S6.04 14.213511.35NoNo079
55G.S5.05 G.S6.04 11.98766.79YesNo099
56b.l1x6 b.l27x1 16.346417.985YesYes699
57b.b2x1 b.l1x6 14.48534.775NoYes689
58b.b2x1 b.b6x1 14.68037.185NoYes089
59b.b6x1 b.l9x6 15.17165.39YesYes098
60G.H2.06 b.l9x6 55.33613.58YesYes398
61G.H2.04 G.H2.07 48.43135NoYes099
62G.H2.04 G.H3.08 48.43559.11NoNo098
63G.H2.06 b.l19x1 54.40575.53YesYes399
64G.H3.17 b.l23x1 13.71786.7YesYes656
652x39 G.H5.23 11.455912.865YesNo094
662x39 2x40 10.93114.22YesYes2199
67b.l17x5 b.l19x1 54.6494.42NoYes069
68b.l17x5 b.l19x2 54.48072.94NoYes069
69b.l17x3 b.l19x2 41.21818.19YesYes299
70b.b19x4 b.l17x3 28.34387.53YesYes289
71b.b19x4 b.b20x6 11.35455.185YesYes286
72b.b17x7 b.b20x6 32.90111.79YesYes286
73b.b17x7 b.b21x1 30.46087.165YesYes287
74b.1x19 b.b21x1 18.03867.145NoYes027
75b.1x15 b.1x19 17.41933.13NoNo042
76b.1x12 b.1x15 16.79964.82NoNo014
77b.1x12 g.h1x11 15.55971.41NoYes019
78b.1x10 g.h1x11 13.69784.845NoYes089
79b.1x10 g.h1x12 13.07672.115NoNo086
80g.h1x12 g.h1x8 12.45545.31NoNo067
81b.1x7 g.h1x8 11.83385.13NoNo057
82b.1x4 b.1x7 11.21192.65NoNo035
83b.b20x4 b.l17x3 11.942919.745YesYes289
84b.b20x4 b.b20x6 22.77175.345YesYes286
85b.b20x2 b.l19x2 12.727212.285YesYes269
86b.b20x2 b.b20x4 11.97155.17YesYes268
87b.l21x7 b.l23x1 18.01154.67NoYes056
88b.b23x6 b.l21x7 16.574.03YesNo075
89b.b23x6 b.b24x6 13.33778.2YesYes1578
90b.b21x7 b.b24x6 12.7729.645YesYes058
91b.l26x5 g.ctx4 23.59223.355NoNo057
92g.ctx3 g.ctx4 23.38684.83YesNo097
93g.ctx3 g.ctx5 16.18544.07YesNo099
94b.lhb1x11 g.ctx5 14.65264.24NoNo049
95b.b28x6 b.lhb1x11 13.76673.49YesNo1094
96b.l25x3 b.l27x2 10.34716.3YesYes1099
97b.b18x3 b.b19x4 16.84346.08YesYes288
98b.b15x2 b.b18x3 16.28086.91YesYes268
99b.b15x2 b.b16x5 15.24534.47YesYes265
100b.b16x5 b.l14x6 15.47375.535YesNo053
101b.b16x7 b.l14x6 15.26754.75YesNo093
102b.b16x7 b.l16x2 14.0253.57YesNo099
103b.l16x1 b.l16x2 13.40053.925NoNo049
104b.l10x1 b.l16x1 13.19182.98YesNo034
105b.b14x5 b.l10x1 10.18855.535NoYes053
106b.b2x5 b.l26x1 23.679911.525YesYes077
107b.l26x3 b.l26x5 22.89777.62NoNo075
108b.l26x1 b.l26x3 23.06935.785YesNo2277
109b.l11x1 b.l9x6 11.33084.345NoYes398
110b.b11x6 b.l11x1 11.15843.71NoNo399
1116x43 6x44 33.90845.48NoYes099
1123x46 6x43 31.95938.615YesNo099
1132x46 3x46 30.67411.93NoYes099
1142x46 2x50 30.45946.09NoYes098
1152x50 3x39 22.099418.73YesNo088
1162x53 3x39 23.88612.05YesNo088
1172x53 Lig 19.3685.36YesYes180
118G.H2.07 b.l9x6 47.5983.86YesYes398
119G.H3.08 G.S4.04 48.47347.31NoNo089
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
3x33Lig9.411NoYes7010
3x36Lig15.721NoYes5010
5x41Lig5.7651YesYes7010
7x34Lig8.9750NoYes6010
7x37Lig7.1851NoYes7010
7x38Lig14.8751NoYes7010
1x43Lig5.751YesYes8010
2x53Lig5.361YesYes8010
E2Lig23.4851YesYes5010
1x32Lig24.341NoYes4010
1x35Lig4.5851NoYes5010
1x36Lig3.671YesYes5010
1x39Lig9.81YesYes8010
2x60Lig12.011YesYes7010
E1Lig43.651YesYes4010
E2x52Lig10.9251YesYes5010
1x28Lig4.331NoYes3010
1x29Lig7.521NoYes2010
LigNT82.5851YesYes0501
1x25Lig14.841NoYes1010
NTNT482.1051YesYes5511
E1NT21.3651YesYes4511
1x281x325.1051NoNo3411
1x361x394.181YesYes5811
1x362x616.221YesNo5712
1x36E13.721YesYes5411
1x391x403.751YesNo8712
1x391x434.9651YesYes8811
1x392x617.4751YesNo8712
1x397x389.9651YesNo8711
1x432x537.7151YesYes8811
1x432x5711.991YesNo8712
1x437x426.361YesNo8912
2x533x368.961YesNo8511
2x533x3912.051YesNo8812
2x533x405.8751YesYes8812
2x573x324.110NoYes7722
2x602x614.841YesNo7712
2x602x644.9351YesYes7712
2x603x3212.1251YesYes7712
2x64E18.9851YesYes7421
E1E131.1751YesYes4411
3x26E29.1651NoYes8521
3x26E2x5116.8251NoYes8922
3x323x364.760YesNo7521
3x334x606.571NoYes7812
3x335x436.1751NoYes7712
3x406x4813.9251YesYes8822
4x60E2x515.6251YesYes8922
4x605x438.811YesYes8722
4x68E24.4251NoYes6521
E2E24.831YesYes5511
E2E2x517.261YesYes5912
E2E2x524.3351YesYes5511
5x37E24.3851YesYes3521
5x41E213.851YesYes7511
5x415x435.8751YesYes7712
5x415x447.541YesNo7712
6x487x378.421YesNo8721
6x517x3310.0250YesYes6821
E3E35.9851YesYes4422
7x33E34.9951YesYes8412
7x337x378.511YesNo8711
7x33Lig4.2251YesYes8010
1x26Lig6.761NoYes2010
3x22NT10.5250NoYes3521
1x221x253.990NoNo2121
1x251x264.5451NoNo1211
2x64E2x524.751YesYes7521
E2x50E2x523.1150NoYes9521
1x291x332.9451NoNo2312
3x29E2x522.730NoYes5521
1x311x352.620NoNo5521
1x357x392.561NoNo5512
1x24NT2.3650NoYes2521
2x62E12.090NoYes2421
1x291x300.761NoNo2212

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
95.45Consensusvpac_onOrthosteric Ligandvpac1_on vpac2_on
80.00Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
76.92Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
76.92Consensusvip-pacap_onOrthosteric Ligandvpac_on pac_on
76.92Consensusvip-pacap_on_gpOrthosteric Ligandvpac_on_gp pac_on_gp
76.00Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
76.00Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
75.00Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ2
73.08Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
73.08Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
72.00Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
72.00Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
72.00Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
71.43Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
70.37Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
69.23Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
69.23Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
68.00Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
68.00Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
67.86Single7RBTTirzepatide7RBT-GIP-Tirzepatide-LSN3556672-chim(NtGi1-Gs)/β1/γ2
66.67Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
66.67Consensusglp_onOrthosteric Ligandglp1_on glp2_on
66.67Consensusglp_on_gpOrthosteric Ligandglp1_on_gp glp2_on_gp
65.38Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
64.00Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
63.33Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
62.96Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
62.96Consensuspac_on_gpOrthosteric Ligandpac1_on_gp
62.07Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
61.54Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
61.54Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
61.54Single9EBOGLP-1 (ACPC18)9EBO-GLP-1-GLP-1 (ACPC18)-Gs/β1/γ2
61.29Consensusglucagon_onOrthosteric Ligandglp_on gluc_on secretin_on gip_on
60.71Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
60.71Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
60.00Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
59.38Consensusglucagon_on_gpOrthosteric Ligandglp_on_gp gluc_on_gp secretin_on_gp gip_on_gp
59.26Consensuspac_onOrthosteric Ligandpac1_on
58.62Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
58.62Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
58.62Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
58.62Single9BYOExendin-39BYO-GLP-1-Exendin-3-Gs/β1/γ2
58.33Consensusclass-b1_on_gpOrthosteric Ligandglucagon_on_gp vip-pacap_on_gp pth_on_gp crf_on_gp calcitonin_on_gp
57.14Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
57.14Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
57.14Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
55.56Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
54.84Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
54.17Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
53.57Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
53.57Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
53.33Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
53.33Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
53.12Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
53.12Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
53.12Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
51.85Single9B5YLong-Acting PTH9B5Y-PTH1-Long-Acting PTH-chim(NtGi1-Gq)/β1/γ2
51.72Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
51.72Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
51.52Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
51.52Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
51.52Consensusclass-a_class-b1_cons_on_gpOrthosteric Ligandclass-a_on_gp class-b1_on_gp
51.43Consensusclass-b1_onOrthosteric Ligandglucagon_on vip-pacap_on pth_on crf_on calcitonin_on
50.00Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
50.00Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
50.00Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
50.00Single8YWFRetatrutide8YWF-GLP-1-Retatrutide-chim(NtGi1-Gs)/β1/γ2
48.48Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
48.48Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
48.39Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
47.22Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
47.06Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
47.06Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
46.88Consensusclass-a_class-b1_cons_onOrthosteric Ligandclass-a_on class-b1_on
46.67Single6FJ3PTH6FJ3-PTH1-PTH
46.67Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
46.67Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
45.71Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
45.71Consensuspth_onOrthosteric Ligandpth1_on pth2_on
45.45Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
45.16Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
45.16Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
45.16Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
44.74Consensuspth_on_gpOrthosteric Ligandpth1_on_gp pth2_on_gp
44.44Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
43.75Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
43.75Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
43.75Consensusvpac2_on_gpOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
43.33Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
42.86Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
42.86Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
42.86Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
42.31Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
41.94Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
41.94Single9BUBCagrilintide9BUB-CT-Cagrilintide-Gs/β1/γ2
41.94Consensuscalcitonin_on_gpOrthosteric Ligandctlike_on_gp
41.38Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
41.38Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
41.38Consensusclass-b1_class-b2_cons_onOrthosteric Ligandclass-b1_on class-b2_on
41.38Consensusclass-b1_class-b2_cons_on_gpOrthosteric Ligandclass-b1_on_gp class-b2_on_gp
41.18Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
40.62Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
40.62Single9BUCCagrilintide9BUC-CT-Cagrilintide-Gs/β1/γ2
40.00Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
40.00Single9BUDCagrilintide9BUD-CT-Cagrilintide-Gs/β1/γ2
39.39Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
39.39Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
39.39Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
39.39Single9BQ3Cagrilintide9BQ3-CT (AMY2)-Cagrilintide-Gs/β1/γ2; RAMP2
39.29Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
38.71Consensuscalcitonin_onOrthosteric Ligandctlike_on
38.71Consensusvpac1_onOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
37.93Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
37.50Single9BLWCagrilintide backbone (non-acylated)9BLW-CT (AMY1)-Cagrilintide backbone (non-acylated)-Gs/β1/γ2; RAMP1
37.50Single9BP3Cagrilintide9BP3-CT (AMY1)-Cagrilintide-Gs/β1/γ2; RAMP1
37.50Consensuspac1_onOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
37.50Consensuspac1_on_gpOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
37.50Consensusvpac1_on_gpOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
37.14Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
36.36Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
36.36Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
36.36Consensussecretin_on_gpOrthosteric Ligand7D3S-Secretin-Secretin-Gs/β1/γ2
36.11Consensuscrf_on_gpOrthosteric Ligandcrf2_on_gp crf1_on_gp
35.48Single9BLCCagrilintide backbone (non-acylated)9BLC-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
35.29Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
35.29Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
35.14Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
34.48Single4XT1Fractalkine4XT1-US28-Fractalkine
34.38Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
34.29Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
34.29Consensusgip_onOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
34.29Consensusgip_on_gpOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
33.33Single4XT3Fractalkine4XT3-US28-Fractalkine
33.33Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
33.33Single9BLBCagrilintide backbone (non-acylated)9BLB-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
33.33Consensussecretin_onOrthosteric Ligand7D3S-Secretin-Secretin-Gs/β1/γ2
32.50Consensuspth2_on_gpOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
32.43Consensusglp1_on_gpOrthosteric Ligand7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
32.43Consensuspth1_on_gpOrthosteric Ligand6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
32.35Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
32.35Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
32.35Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
32.35Consensusglp2_on_gpOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
32.14Single9C0KExendin-49C0K-GLP-1-Exendin-4-Gs/β1/γ2
31.58Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
31.43Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
31.43Single9BTWCagrilintide9BTW-CT (AMY3)-Cagrilintide-Gs/β1/γ2; RAMP3
31.43Consensuspth1_onOrthosteric Ligand6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
31.25Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
31.25Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
31.25Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
31.25Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
31.25Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
31.25Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
31.25Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
31.03Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
30.30Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
30.30Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
30.30Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
30.00Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
30.00Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
30.00Single9BUECagrilintide9BUE-CT-Cagrilintide-Gs/β1/γ2
29.73Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
29.73Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
29.73Consensusglp1_onOrthosteric Ligand7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
29.41Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
29.41Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
29.41Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
29.03Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
29.03Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
29.03Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
29.03Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
29.03Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
28.57Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
28.57Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
28.57Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
28.57Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
28.57Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
28.57Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
28.12Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
28.12Consensusangiotensin_onOrthosteric Ligandat1_on
28.12Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
28.12Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
27.91Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
27.78Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
27.59Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
27.27Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
27.27Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
27.03Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
27.03Consensuscrf1_onOrthosteric Ligand6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF1-Corticoliberin-Gs/β1/γ2
26.92Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
26.92Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
26.92Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
26.83Consensusgluc_on_gpOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
26.67Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
26.67Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
26.47Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
25.93Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
25.93Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
25.93Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
25.81Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
25.81Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
25.81Consensuslpl_onOrthosteric Ligands1p_on lpa_on
25.81Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
25.71Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
25.71Single9KFKRelaxin-39KFK-RXFP4-Relaxin-3-Gi2/β1/γ2
25.71Consensuscrf2_on_gpOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
25.64Consensuscrf1_on_gpOrthosteric Ligand6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF1-Corticoliberin-Gs/β1/γ2
25.00Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
25.00Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single7TUYGSK682753A7TUY-GPR183-GSK682753A
25.00Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
25.00Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
25.00Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
25.00Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
24.39Consensusgluc_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
24.32Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
24.24Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
24.24Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
24.24Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
24.24Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
24.14Single6OS2TRV0266OS2-AT1-TRV026
24.14Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
24.14Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
24.14Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
24.14Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
24.14Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
24.14Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
24.14Consensuslpa_offOrthosteric Ligandlpa1_off
24.14Consensuslpl_offOrthosteric Ligands1p_off lpa_off
24.00Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
24.00Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
23.68Single5GLHEndothelin-15GLH-ETB-Endothelin-1
23.68Single6IGKEndothelin-36IGK-ETB-Endothelin-3
23.68Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
23.53Single6JODAngiotensin II6JOD-AT2-Angiotensin II
23.53Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
23.53Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
23.53Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
23.53Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
23.53Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
23.53Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
23.53Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
23.53Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
23.53Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
23.53Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
23.53Consensusvasop-oxy_onOrthosteric Ligandv2_on
23.53Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
23.33Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
23.33Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
23.33Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
23.33Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
23.33Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
23.08Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
23.08Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
23.08Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
22.86Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
22.86Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
22.86Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
22.86Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
22.86Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
22.86Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
22.86Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
22.86Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
22.86Single8ZRTET-18ZRT-ETB-ET-1
22.86Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
22.86Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
22.86Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
22.86Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
22.86Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
22.86Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
22.86Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
22.86Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
22.86Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
22.73Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
22.73Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
22.58Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
22.58Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
22.58Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
22.58Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
22.58Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
22.58Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
22.58Single9M0RNeuropeptide VF9M0R-NPFF1-Neuropeptide VF-Gi1/β1/γ2
22.58Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
22.58Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
22.50Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
22.22Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
22.22Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
22.22Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
22.22Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
22.22Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
22.22Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
22.22Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
22.22Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
22.22Consensusa3_onOrthosteric Liganda3a_on
22.22Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
22.22Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
22.22Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
22.22Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
22.22Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
22.22Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
22.22Consensushca_on_gpOrthosteric Ligandhca2_on_gp
22.22Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
22.22Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
21.88Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
21.88Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
21.88Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
21.88Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
21.88Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
21.88Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
21.88Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
21.88Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
21.88Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
21.62Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
21.62Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
21.62Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
21.62Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
21.62Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
21.62Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
21.62Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
21.62Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
21.43Single5C1MBU725C1M-μ-BU72
21.43Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
21.43Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
21.43Single7LD3Adenosine7LD3-A1-Adenosine-MIPS521-Gi2/β1/γ2
21.43Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
21.43Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.43Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
21.43Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
21.43Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
21.43Single8S4DCMF-0198S4D-Apelin-CMF-019
21.43Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
21.43Single8XYKVUF106618XYK-CXCR3-VUF10661-Go/β1/γ2
21.43Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
21.43Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Single9B9ZA1AKO9B9Z-CB1-A1AKO
21.43Single9CIBFCH-22964139CIB-HCA2-FCH-2296413
21.43Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
21.43Single9EHSLUF76029EHS-A3A-LUF7602
21.43Consensusa3_on_gpOrthosteric Liganda3a_on_gp
21.43Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
21.43Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
21.43Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
21.43Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
21.43Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
21.43Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
21.43Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
21.21Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
21.21Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
21.21Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
21.21Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
21.21Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
21.21Single9E82SDF-1-beta9E82-ACKR3-SDF-1-β-Arrestin2
21.21Single9IQSMuscarinic toxin 39IQS-M4-Muscarinic toxin 3
21.21Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
21.21Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
21.21Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
21.21Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
21.21Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
21.21Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
21.05Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
21.05Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
21.05Consensusbradykinin_onOrthosteric Ligandbk2_on
21.05Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
21.05Consensusctlike_on_gpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
21.05Consensusendothelin_onOrthosteric Ligandetb_on eta_on
21.05Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
20.83Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.83Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
20.83Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
20.69Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
20.69Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
20.69Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
20.69Single6OS1TRV0266OS1-AT1-TRV026
20.69Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
20.69Single7F1TMIP-1a7F1T-CCR5-MIP-1a
20.69Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
20.69Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
20.69Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
20.69Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
20.69Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
20.69Single8E0GBU728E0G-μ-BU72
20.69Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
20.69Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
20.69Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
20.69Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
20.69Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
20.69Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
20.69Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
20.69Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
20.69Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
20.69Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
20.69Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
20.69Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
20.69Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
20.69Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
20.69Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
20.69Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
20.69Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
20.69Consensuslpa_onOrthosteric Ligandlpa1_on
20.69Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
20.69Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
20.69Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
20.69Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
20.59Single3OE0CVX153OE0-CXCR4-CVX15
20.59Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
20.59Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
20.59Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
20.59Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
20.59Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
20.59Single9U4WGonadoliberin-19U4W-GnRH1-Gonadoliberin-1-chim(NtGi1L-Gs-CtGq)/β1/γ2
20.59Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
20.59Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
20.59Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
20.59Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
20.59Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
20.51Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
20.51Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
20.51Consensusbombesin_onOrthosteric Ligandbb2_on
20.51Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
20.51Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
20.00Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
20.00Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
20.00Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
20.00Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
20.00Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
20.00Single6LI0C176LI0-GPR52-C17
20.00Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
20.00Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
20.00Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
20.00Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
20.00Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
20.00Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
20.00Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
20.00Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
20.00Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
20.00Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
20.00Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
20.00Single8JWY2-1188JWY-A2A-2-118
20.00Single8JWZAB9288JWZ-A2A-AB928-Na
20.00Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
20.00Single8K5BNiacin8K5B-HCA2-Niacin
20.00Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab
20.00Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
20.00Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
20.00Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
20.00Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
20.00Single8XYIVUF106618XYI-CXCR3-VUF10661
20.00Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
20.00Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
20.00Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
20.00Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
20.00Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
20.00Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
20.00Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
20.00Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
20.00Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
20.00Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
20.00Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
20.00Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
20.00Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
20.00Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
20.00Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
20.00Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
20.00Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
19.51Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
19.44Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
19.44Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
19.44Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
19.44Single9JFYhNPSF9JFY-NPFF2-hNPSF-Gi1/β1/γ2
19.44Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
19.44Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
19.44Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
19.35Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
19.35Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
19.35Single7EZCUKA7EZC-A2A-UKA
19.35Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
19.35Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
19.35Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
19.35Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
19.35Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
19.35Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
19.35Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
19.35Single8ZWGJR14a8ZWG-C3aB-JR14a-Gi1/β1/γ2
19.35Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
19.35Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
19.35Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
19.35Single9M54Neuropeptide VF9M54-NPFF2-Neuropeptide VF-Gi1/β1/γ2
19.35Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
19.35Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
19.35Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
19.35Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
19.35Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
19.23Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
19.23Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
19.23Single5U09Taranabant5U09-CB1-Taranabant
19.23Single6AKXA4R6AKX-CCR5-A4R
19.23Single6AKYMaraviroc6AKY-CCR5-Maraviroc
19.23Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
19.23Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
19.23Single7VVOPTH7VVO-PTH1-PTH-Gs/β1/γ2
19.23Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
19.23Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
19.23Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.23Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
19.23Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
19.23Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
19.23Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
19.23Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
19.23Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
19.23Single9EBHAdenosine9EBH-A3A-Adenosine-Gi1/β1/γ2
19.23Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
19.23Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
19.23Consensusangiotensin_offOrthosteric Ligandat1_off
19.23Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
19.23Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
19.23Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
19.23Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
18.92Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
18.92Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
18.92Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
18.92Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
18.92Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
18.92Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
18.92Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
18.92Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
18.75Single3NY9ICI118-5513NY9-β2-ICI118-551
18.75Single4UG2CGS216804UG2-A2A-CGS21680
18.75Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
18.75Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
18.75Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
18.75Single7SK9CCX6627SK9-ACKR3-CCX662
18.75Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
18.75Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
18.75Single8QJ2pN1628QJ2-MC4-pN162-Gs
18.75Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
18.75Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
18.75Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
18.75Single8Y72Peptide8Y72-μ-Peptide-BMS-986122-Gi1/β1/γ2
18.75Single9IPVJR14a9IPV-C3aB-JR14a-Gi1/β1/γ2
18.75Single9IPYJR14a9IPY-C3aB-JR14a
18.75Single9IZASCH9002719IZA-HCA2-SCH900271-Gi1/β1/γ2
18.75Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
18.75Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
18.75Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
18.52Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
18.52Single4MBSMaraviroc4MBS-CCR5-Maraviroc
18.52Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
18.52Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
18.52Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
18.52Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
18.52Single7F61PF-036547467F61-H3-PF-03654746
18.52Single7T32ZM-2413857T32-A2A-ZM-241385
18.52Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
18.52Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
18.52Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
18.52Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
18.52Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
18.52Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
18.52Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
18.52Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
18.52Single8K2WAMG4878K2W-CXCR3-AMG487
18.52Single8K5CAcipimox8K5C-HCA2-Acipimox
18.52Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
18.52Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
18.52Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
18.52Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
18.52Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
18.52Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
18.52Single9JFUNE52-QQ579JFU-GPR4-NE52-QQ57
18.52Single9JH3CMF-0199JH3-Apelin-CMF-019-Gi1/β1/γ2
18.52Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
18.52Single9K0KUTP9K0K-P2Y4-UTP-chim(NtGi1-Gs-CtGq)/β1/γ2
18.52Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
18.52Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
18.52Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
18.52Consensushca_onOrthosteric Ligandhca2_on
18.52Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
18.42Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
18.42Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
18.42Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
18.18Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
18.18Single7QA8Peptide7QA8-STE2-Peptide
18.18Single7QA8Peptide7QA8-STE2-Peptide
18.18Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
18.18Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
18.18Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
18.18Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
18.18Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
18.18Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
18.18Single8U4OCXCL128U4O-CXCR4-CXCL12-Gi1/β1/γ2
18.18Single8WDTphotoNECA8WDT-A2A-photoNECA
18.18Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
18.18Single9BUYLM1899BUY-β2-LM189-Gi1/β1/γ2
18.18Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
18.18Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
18.18Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
18.18Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
18.18Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
18.18Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
17.95Single6IGLIRL16206IGL-ETB-IRL1620
17.95Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
17.95Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
17.95Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
17.95Single8IY6Endothelin-18IY6-ETB-Endothelin-1
17.86Single4YAYZD-71554YAY-AT1-ZD-7155
17.86Single5UENDU1725UEN-A1-DU172
17.86Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
17.86Single6PS1Timolol6PS1-β2-Timolol
17.86Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
17.86Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
17.86Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
17.86Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
17.86Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
17.86Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
17.86Single7V3ZCP559407V3Z-CB1-CP55940
17.86Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
17.86Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
17.86Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
17.86Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
17.86Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
17.86Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
17.86Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
17.86Single8K5DGSK2560738K5D-HCA2-GSK256073
17.86Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
17.86Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
17.86Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
17.86Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
17.86Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
17.86Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
17.86Single9CHXS-Carazolol9CHX-β2-S-Carazolol
17.86Single9H37A1IR09H37-A2A-A1IR0-Na
17.86Single9IZCMK19039IZC-HCA2-MK1903-Gi1/β1/γ2
17.86Single9KFJPubChem 1383196749KFJ-RXFP3-PubChem 138319674-Gi2/β1/γ2
17.86Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
17.86Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
17.65Single3QAKUK-4320973QAK-A2A-UK-432097
17.65Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
17.65Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
17.65Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
17.65Single7XNACYN1548067XNA-SST2-CYN154806
17.65Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
17.65Single9IQVMuscarinic toxin 39IQV-Alpha1A-Muscarinic toxin 3
17.65Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
17.65Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
17.65Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
17.65Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
17.65Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
17.50Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
17.50Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
17.50Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
17.50Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
17.24Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
17.24Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
17.24Single6D26Fevipiprant6D26-DP2-Fevipiprant
17.24Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
17.24Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
17.24Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
17.24Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
17.24Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
17.24Single7C4SS1P7C4S-S1P3-S1P
17.24Single7C61Ergotamine7C61-5-HT1B-Ergotamine
17.24Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
17.24Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
17.24Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
17.24Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
17.24Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
17.24Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
17.24Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
17.24Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
17.24Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
17.24Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
17.24Single8JXSPF-61428JXS-D1-PF-6142
17.24Single8TF5Oleic acid8TF5-GPR6-Oleic acid
17.24Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
17.24Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
17.24Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
17.24Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
17.24Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
17.24Single8ZYTNeurotensin peptide 8-138ZYT-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
17.24Single9EE8Adenosine9EE8-A2A-Adenosine-Gs/β1/γ2
17.24Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
17.24Single9I52A1IZU9I52-D1-A1IZU-Gs/β1/γ2
17.24Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
17.24Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
17.24Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
17.24Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
17.24Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
17.24Consensusdp_offOrthosteric Liganddp2_off
17.24Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
17.24Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
17.24Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
17.24Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
17.24Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
17.24Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
17.24Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.24Consensustrace-amine_onOrthosteric Ligandta1_on
17.14Single5WF5UK-4320975WF5-A2A-UK-432097
17.14Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
17.14Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
17.14Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
17.14Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
17.14Single9M1OMorphine-Modulating Neuropeptide B9M1O-NPFF2-Morphine-Modulating Neuropeptide B-Gi1/β1/γ2
17.14Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
17.14Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
17.14Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
17.14Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
17.14Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
17.14Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
17.07Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
17.07Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
17.07Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
16.67Single2YDVNECA2YDV-A2A-NECA
16.67Single3P0GBI1671073P0G-β2-BI167107
16.67Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
16.67Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
16.67Single4UHRCGS216804UHR-A2A-CGS21680
16.67Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
16.67Single5G53NECA5G53-A2A-NECA-Gs
16.67Single5XR8AM8415XR8-CB1-AM841
16.67Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
16.67Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
16.67Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
16.67Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
16.67Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
16.67Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
16.67Single7FEECP559407FEE-CB1-CP55940-ZCZ011
16.67Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
16.67Single7PX4PSB-21137PX4-A2A-PSB-2113
16.67Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
16.67Single7T9NDPPC7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
16.67Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
16.67Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
16.67Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
16.67Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
16.67Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
16.67Single8A2OTheophylline8A2O-A2A-Theophylline-Na
16.67Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
16.67Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
16.67Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
16.67Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
16.67Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
16.67Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
16.67Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
16.67Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
16.67Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
16.67Single8Y73Peptide8Y73-μ-Peptide-MPAM-15-Gi1/β1/γ2
16.67Single8ZBISomatostatin-148ZBI-SST3-Somatostatin-14-Gi1/β1/γ2
16.67Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
16.67Single8ZWFJR14a8ZWF-C3aB-JR14a
16.67Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
16.67Single9EE9Adenosine9EE9-A2A-Adenosine-Gs/β1/γ2
16.67Single9I54A1IZV9I54-D1-A1IZV-Gs/β1/γ2
16.67Single9JMCDS-3801b9JMC-Motilin-DS-3801b-chim(Gs-CtGq)/β1/γ2
16.67Consensusa2_onOrthosteric Liganda2b_on
16.67Consensusa2_on_gpOrthosteric Liganda2b_on_gp
16.67Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
16.67Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
16.67Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
16.67Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
16.67Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
16.67Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
16.67Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
16.67Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
16.67Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
16.67Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
16.67Consensusrelaxin_onOrthosteric Ligandrxfp4_on
16.67Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
16.67Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
16.67Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
16.28Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
16.22Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
16.22Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
16.22Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
16.22Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
16.22Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
16.22Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
16.13Single4XEENeurotensin4XEE-NTS1-Neurotensin
16.13Single4XESNeurotensin4XES-NTS1-Neurotensin
16.13Single6A93Risperidone6A93-5-HT2A-Risperidone
16.13Single6KQICP559406KQI-CB1-CP55940-Org27569
16.13Single6MXTSalmeterol6MXT-β2-Salmeterol
16.13Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
16.13Single6YVRNTS8-136YVR-NTS1-NTS8-13
16.13Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
16.13Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
16.13Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
16.13Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
16.13Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
16.13Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
16.13Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
16.13Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
16.13Single7YITNalfurafine7YIT-κ-Nalfurafine
16.13Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
16.13Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
16.13Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
16.13Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
16.13Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
16.13Single8JJ8Formoterol8JJ8-β2-Formoterol
16.13Single8JJLOlodaterol8JJL-β2-Olodaterol
16.13Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
16.13Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
16.13Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
16.13Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
16.13Single8XJNCloprosetnol8XJN-TXA2-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
16.13Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
16.13Single9DGIZ85267113509DGI-CB1-Z8526711350
16.13Single9EBIPiclidenoson9EBI-A3A-Piclidenoson-chim(NtGi1L-Gs-CtGi1)/β1/γ2
16.13Single9GL2Befiradol9GL2-5-HT1A-Befiradol-Gs/β1/γ2
16.13Single9M4QDoxazosin9M4Q-Alpha1A-Doxazosin
16.13Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
16.13Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
16.13Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
16.13Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
16.13Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
16.13Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
16.13Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
16.13Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
16.13Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
16.13Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
16.13Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
16.13Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
16.13Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
16.00Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.00Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
16.00Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
16.00Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
16.00Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
15.79Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
15.79Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
15.62Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
15.62Single4BUONeurotensin4BUO-NTS1-Neurotensin
15.62Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
15.62Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
15.62Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
15.62Single5X93K-87945X93-ETB-K-8794
15.62Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
15.62Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
15.62Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
15.62Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
15.62Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
15.62Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
15.62Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.62Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
15.62Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
15.62Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
15.62Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.62Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
15.62Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
15.62Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-SBI-553-chim(NtGi1-Go)/β1/γ2
15.62Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
15.62Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
15.62Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
15.62Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
15.62Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
15.62Single8XJOU466198XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
15.62Single8XVUCXCL28XVU-CXCR2-CXCL2
15.62Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
15.62Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
15.62Single9DYEBuspirone9DYE-5-HT1A-Buspirone-Go/β1/γ2
15.62Single9M1HProstaglandin E29M1H-EP1-Prostaglandin E2-chim(NtGi1-Gs-CtGq)/β1/γ2
15.62Consensuscck_onOrthosteric Ligandccka_on cckb_on
15.62Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
15.62Consensuschemerin_onOrthosteric Ligandcml1_on
15.62Consensusendothelin_offOrthosteric Ligandetb_off
15.62Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
15.62Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.62Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.62Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
15.62Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
15.62Consensusprostanoid_offOrthosteric Ligandep_off dp_off
15.62Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
15.62Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
15.62Consensustp_onOrthosteric Ligand8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
15.62Consensustp_on_gpOrthosteric Ligand8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Single3OE9IT1t3OE9-CXCR4-IT1t
15.38Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
15.38Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
15.38Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
15.38Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
15.38Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
15.38Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
15.38Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
15.38Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
15.38Single8YKDDehydroepiandrosterone8YKD-ADGRG2-Dehydroepiandrosterone-chim(NtGi1-Gs)/β1/γ2
15.38Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
15.38Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
15.38Single9B9Y7DY9B9Y-CB1-7DY
15.38Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
15.38Single9LMPNE52-QQ579LMP-GPR4-NE52-QQ57
15.38Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
15.15Single5WF6UK-4320975WF6-A2A-UK-432097
15.15Single5ZTYAM102575ZTY-CB2-AM10257
15.15Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
15.15Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
15.15Single6PT3DPI-2876PT3-δ-DPI-287
15.15Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
15.15Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
15.15Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
15.15Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
15.15Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
15.15Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
15.15Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
15.15Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
15.15Single9CGKC5-Quino9CGK-δ-C5-Quino-Gi1/β1/γ2
15.15Single9MD1Buspirone9MD1-5-HT1A-Buspirone-Gz/β1/γ2
15.15Single9V2NMacimorelin9V2N-Ghrelin-Macimorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
15.15Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
15.15Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
15.15Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
15.15Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
15.15Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
15.15Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
15.15Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
15.00Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
15.00Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
15.00Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
14.81Single3ODUIT1t3ODU-CXCR4-IT1t
14.81Single3PWHZM-2413853PWH-A2A-ZM-241385
14.81Single4BWBNeurotensin4BWB-NTS1-Neurotensin
14.81Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
14.81Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
14.81Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
14.81Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
14.81Single5ZKQABT-4915ZKQ-PAF-ABT-491
14.81Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
14.81Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
14.81Single6ME2Ramelteon6ME2-MT1-Ramelteon
14.81Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
14.81Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
14.81Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
14.81Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
14.81Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
14.81Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
14.81Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
14.81Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
14.81Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
14.81Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.81Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
14.81Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.81Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
14.81Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
14.81Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
14.81Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
14.81Single8GNGIstradefylline8GNG-A2A-Istradefylline
14.81Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
14.81Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
14.81Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
14.81Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
14.81Single8IWESpermidine8IWE-TA9-Spermidine
14.81Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
14.81Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
14.81Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
14.81Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
14.81Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
14.81Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
14.81Single8U4PAMD31008U4P-CXCR4-AMD3100-Gi1/β1/γ2
14.81Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
14.81Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
14.81Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
14.81Single9EEAAdenosine9EEA-A2A-Adenosine-Gs/β1/γ2
14.81Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
14.81Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
14.81Consensusalpha2_offOrthosteric Ligandalpha2c_off
14.81Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
14.81Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
14.71Single4IARErgotamine4IAR-5-HT1B-Ergotamine
14.71Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
14.71Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
14.71Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
14.71Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
14.71Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
14.71Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
14.71Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
14.71Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
14.71Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
14.71Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
14.71Single8PKMBefiradol8PKM-5-HT1A-Befiradol-Gi1/β1/γ1
14.71Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
14.71Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
14.71Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
14.71Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
14.71Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
14.71Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
14.71Consensussomatostatin_offOrthosteric Ligandsst2_off
14.63Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
14.29Single2YDOAdenosine2YDO-A2A-Adenosine
14.29Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
14.29Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
14.29Single5IU7Q274563465IU7-A2A-Q27456346-Na
14.29Single5IUBQ274563445IUB-A2A-Q27456344-Na
14.29Single5JTBZM-2413855JTB-A2A-ZM-241385
14.29Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
14.29Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
14.29Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
14.29Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
14.29Single6AQFZM-2413856AQF-A2A-ZM-241385
14.29Single6HLOAprepitant6HLO-NK1-Aprepitant
14.29Single6MH8ZM-2413856MH8-A2A-ZM-241385
14.29Single6PS0S-Carazolol6PS0-β2-S-Carazolol
14.29Single6PS4ICI118-5516PS4-β2-ICI118-551
14.29Single6PS5S-Propranolol6PS5-β2-S-Propranolol
14.29Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
14.29Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
14.29Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
14.29Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
14.29Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
14.29Single7AROLUF58337ARO-A2A-LUF5833-Na
14.29Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
14.29Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
14.29Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
14.29Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
14.29Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
14.29Single7SK5CXCL127SK5-ACKR3-CXCL12
14.29Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
14.29Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
14.29Single7T94LY21196207T94-M2-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
14.29Single7UL3Famotidine7UL3-H2-Famotidine
14.29Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
14.29Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
14.29Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
14.29Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
14.29Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
14.29Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
14.29Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
14.29Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
14.29Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
14.29Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
14.29Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.29Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.29Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.29Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
14.29Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
14.29Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
14.29Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
14.29Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
14.29Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
14.29Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
14.29Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
14.29Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single8IHKAcifran8IHK-HCA3-Acifran
14.29Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
14.29Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
14.29Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
14.29Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
14.29Single8K9LDamgo8K9L-μ-Damgo-BMS-986122-Gi3/β1/γ1
14.29Single8RLNLUF58348RLN-A2A-LUF5834
14.29Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
14.29Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
14.29Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
14.29Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
14.29Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
14.29Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.29Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.29Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
14.29Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
14.29Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
14.29Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
14.29Single8Y6YGLPG09748Y6Y-FFA2-GLPG0974
14.29Single8ZPMAMD0708ZPM-CXCR4-AMD070
14.29Single9AS5Mescaline9AS5-5-HT2A-Mescaline
14.29Single9AS6Mescaline9AS6-5-HT2A-Mescaline-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single9BA0A1AKN9BA0-CB1-A1AKN
14.29Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
14.29Single9JMDAzithromycin9JMD-Motilin-Azithromycin-chim(Gs-CtGq)/β1/γ2
14.29Single9K0XATP9K0X-P2Y2-ATP-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single9K20ATP9K20-P2Y2-ATP-chim(NtGi1-Go)/β1/γ2
14.29Single9KFIRelaxin-39KFI-RXFP3-Relaxin-3-Gi2/β1/γ2
14.29Single9M2FNeuropeptide FF9M2F-NPFF1-Neuropeptide FF-Gi1/β1/γ2
14.29Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
14.29Consensusa2_offOrthosteric Liganda2a_off
14.29Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
14.29Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
14.29Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
14.29Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
14.29Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
14.29Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
14.29Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
14.29Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
13.89Single6PT2KGCHM076PT2-δ-KGCHM07
13.89Single6W25SHU91196W25-MC4-SHU9119-Ca
13.89Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
13.89Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.89Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
13.89Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
13.89Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
13.89Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
13.89Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
13.89Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
13.89Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
13.89Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
13.79Single2Y04Salbutamol2Y04-β1-Salbutamol
13.79Single3EMLZM-2413853EML-A2A-ZM-241385
13.79Single3NY8ICI118-5513NY8-β2-ICI118-551
13.79Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
13.79Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
13.79Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
13.79Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
13.79Single4GBRS-Carazolol4GBR-β2-S-Carazolol
13.79Single4QKX35V4QKX-β2-35V
13.79Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
13.79Single5DHHSB-6121115DHH-NOP-SB-612111
13.79Single5IU8Q274563475IU8-A2A-Q27456347-Na
13.79Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
13.79Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
13.79Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
13.79Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
13.79Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
13.79Single5UIGCmpd-15UIG-A2A-Cmpd-1
13.79Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
13.79Single6D27CAY104716D27-DP2-CAY10471
13.79Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
13.79Single6GPSMK08126GPS-CCR2-MK0812
13.79Single6H7MSalbutamol6H7M-β1-Salbutamol
13.79Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
13.79Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
13.79Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
13.79Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/β1/γ2
13.79Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
13.79Single6S0LZM-2413856S0L-A2A-ZM-241385
13.79Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
13.79Single6XBM5LWE6XBM-SMO-5LWE-Gi1/β1/γ2
13.79Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
13.79Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
13.79Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
13.79Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
13.79Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
13.79Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
13.79Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
13.79Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
13.79Single7PYRPSB-21157PYR-A2A-PSB-2115
13.79Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
13.79Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
13.79Single7UL4Alvimopan7UL4-μ-Alvimopan
13.79Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
13.79Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
13.79Single7WC7Lisuride7WC7-5-HT2A-Lisuride
13.79Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
13.79Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
13.79Single8CU6LJ-45178CU6-A2A-LJ-4517
13.79Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
13.79Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
13.79Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
13.79Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
13.79Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
13.79Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.79Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.79Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.79Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.79Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.79Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.79Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.79Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.79Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.79Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.79Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
13.79Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
13.79Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
13.79Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
13.79Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
13.79Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
13.79Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
13.79Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
13.79Single8JJOAlprenolol8JJO-β2-Alprenolol
13.79Single8JXRLSD8JXR-D1-LSD
13.79Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
13.79Single8PJKST1718PJK-5-HT1A-ST171-Gi1/β1/γ1
13.79Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
13.79Single8T1WCVN4248T1W-GPR6-CVN424
13.79Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
13.79Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.79Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.79Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.79Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.79Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
13.79Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
13.79Single9AS1DMT9AS1-5-HT2A-DMT
13.79Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
13.79Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
13.79Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
13.79Consensus5ht5_onOrthosteric Ligand5ht5a_on
13.79Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
13.79Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
13.79Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
13.79Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
13.79Consensusblt_onOrthosteric Ligandblt1_on
13.79Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
13.79Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
13.79Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
13.79Consensusdopamine_offOrthosteric Ligandd2_off d3_off
13.79Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
13.79Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
13.79Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
13.79Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
13.79Consensusleukotriene_onOrthosteric Ligandblt_on
13.79Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
13.51Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
13.51Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
13.51Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
13.33Single2RH1S-Carazolol2RH1-β2-S-Carazolol
13.33Single2Y03Isoprenaline2Y03-β1-Isoprenaline
13.33Single2YCWS-Carazolol2YCW-β1-S-Carazolol
13.33Single4JKVTaladegib4JKV-SMO-Taladegib
13.33Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
13.33Single5D6LS-Carazolol5D6L-β2-S-Carazolol
13.33Single5IUAQ274563485IUA-A2A-Q27456348-Na
13.33Single5JQHS-Carazolol5JQH-β2-S-Carazolol
13.33Single5N2RPSB-365N2R-A2A-PSB-36-Na
13.33Single5N2SPSB365N2S-A1-PSB36
13.33Single5T1ABMS-6815T1A-CCR2-BMS-681-PubChem 12093170
13.33Single5TVNLSD5TVN-5-HT2B-LSD
13.33Single5WIUNemonapride5WIU-D4-Nemonapride
13.33Single5WIVNemonapride5WIV-D4-Nemonapride-Na
13.33Single5X7DS-Carazolol5X7D-β2-S-Carazolol-Cmpd-15
13.33Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
13.33Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
13.33Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
13.33Single6E67BI1671076E67-β2-BI167107-Gs(CT)
13.33Single6GPXMK08126GPX-CCR2-MK0812
13.33Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
13.33Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
13.33Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
13.33Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
13.33Single6PS6Timolol6PS6-β2-Timolol
13.33Single6S0QZM-2413856S0Q-A2A-ZM-241385
13.33Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
13.33Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
13.33Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
13.33Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
13.33Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
13.33Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
13.33Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
13.33Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
13.33Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.33Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
13.33Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
13.33Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
13.33Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.33Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.33Single8GNEKW-63568GNE-A2A-KW-6356-Na
13.33Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
13.33Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
13.33Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
13.33Single8QOTNanobody-E8QOT-μ-Nanobody-E
13.33Single8WGBVU01550418WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
13.33Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
13.33Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
13.33Single9F33FOB02-04A9F33-D3-FOB02-04A-Go/β1/γ2
13.33Single9F34FOB02-04A9F34-D3-FOB02-04A-Go/β1/γ2
13.33Single9K07DSO-5a9K07-BB3-DSO-5a-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.33Single9KPFSA09KPF-TAS2R16-SA0-Gi1/β1/γ2
13.33Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
13.33Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
13.33Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
13.33Consensusadenosine_offOrthosteric Liganda1_off a2_off
13.33Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
13.33Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
13.33Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
13.33Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
13.33Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
13.33Consensusamine_offonOrthosteric Ligandamine_off amine_on
13.33Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
13.33Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
13.33Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
13.33Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
13.33Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
13.33Consensusblt_offOrthosteric Ligandblt1_off
13.33Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
13.33Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
13.33Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
13.33Consensusep_offOrthosteric Ligandep4_off
13.33Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
13.33Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
13.33Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
13.33Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
13.16Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
13.16Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
13.16Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
13.04Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
12.90Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
12.90Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
12.90Single4BV0Neurotensin4BV0-NTS1-Neurotensin
12.90Single4DJHJDTic4DJH-κ-JDTic
12.90Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
12.90Single5D5AS-Carazolol5D5A-β2-S-Carazolol
12.90Single5D5BS-Carazolol5D5B-β2-S-Carazolol
12.90Single5V56TC1145V56-SMO-TC114
12.90Single5V57TC1145V57-SMO-TC114
12.90Single5XRAAM115425XRA-CB1-AM11542
12.90Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
12.90Single6H7JIsoprenaline6H7J-β1-Isoprenaline
12.90Single6J21Aprepitant6J21-NK1-Aprepitant
12.90Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
12.90Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
12.90Single6TQ7SB-3348676TQ7-OX1-SB-334867
12.90Single6WGTLSD6WGT-5-HT2A-LSD
12.90Single7B6WCyclazosin7B6W-α1b-Cyclazosin
12.90Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
12.90Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
12.90Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
12.90Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
12.90Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
12.90Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
12.90Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
12.90Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
12.90Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.90Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.90Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
12.90Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
12.90Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
12.90Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
12.90Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
12.90Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
12.90Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
12.90Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
12.90Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
12.90Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
12.90Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
12.90Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
12.90Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
12.90Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
12.90Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
12.90Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
12.90Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
12.90Single9BJKNaloxone9BJK-μ-Naloxone-NAM
12.90Single9EGOYVF9EGO-CB1-YVF-Gi1/β1/γ2
12.90Single9IK9SST analogue9IK9-SST1-SST analogue-Gi1/β1/γ2
12.90Single9UY3Anamorelin9UY3-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
12.90Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
12.90Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
12.90Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
12.90Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
12.90Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
12.90Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
12.90Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
12.90Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
12.90Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
12.90Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
12.90Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
12.90Consensusneurotensin_onOrthosteric Ligandnts1_on
12.90Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
12.90Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
12.82Single7SK3CXCL127SK3-ACKR3-CXCL12
12.82Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
12.82Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
12.82Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
12.50Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
12.50Single3D4STimolol3D4S-β2-Timolol
12.50Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
12.50Single4AMIBucindolol4AMI-β1-Bucindolol
12.50Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
12.50Single4LDEBI1671074LDE-β2-BI167107
12.50Single4N4WSANT-14N4W-SMO-SANT-1
12.50Single4RWADIPP-NH24RWA-δ-DIPP-NH2
12.50Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
12.50Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
12.50Single6CM4Risperidone6CM4-D2-Risperidone
12.50Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
12.50Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
12.50Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
12.50Single6IIURamatroban6IIU-TXA2-Ramatroban
12.50Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
12.50Single6ZG4HTL00099366ZG4-M1-HTL0009936
12.50Single7DFPSpiperone7DFP-D2-Spiperone
12.50Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
12.50Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
12.50Single7K15MKD0467K15-BLT1-MKD046-Na
12.50Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
12.50Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
12.50Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
12.50Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
12.50Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
12.50Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
12.50Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
12.50Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
12.50Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
12.50Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
12.50Single8HS2Fab0468HS2-GPR20-Fab046
12.50Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
12.50Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
12.50Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
12.50Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
12.50Single8PWNTheophylline8PWN-A2A-Theophylline
12.50Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
12.50Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
12.50Single8XQJJN2418XQJ-Apelin-JN241
12.50Single8XWMCXCL68XWM-CXCR2-CXCL6
12.50Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
12.50Single9GGGI-BOP9GGG-TXA2-I-BOP-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
12.50Single9KDFRES-701-39KDF-ETB-RES-701-3
12.50Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
12.50Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
12.50Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
12.50Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
12.50Consensusalpha1_offOrthosteric Ligandalpha1a_off
12.50Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
12.50Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
12.50Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
12.50Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
12.50Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
12.50Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
12.50Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
12.50Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
12.50Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
12.50Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
12.50Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
12.50Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
12.50Consensusorexin_onOrthosteric Ligandox2_on
12.50Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
12.50Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
12.20Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
12.12Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
12.12Single6H7LDobutamine6H7L-β1-Dobutamine
12.12Single6IBLArformoterol6IBL-β1-Arformoterol
12.12Single6K1QIRL25006K1Q-ETB-IRL2500
12.12Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
12.12Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
12.12Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
12.12Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
12.12Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
12.12Single7UM4AS26747237UM4-5-HT5A-AS2674723
12.12Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
12.12Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
12.12Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
12.12Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
12.12Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
12.12Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
12.12Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
12.12Single8JPFNeurotensin8JPF-NTS1-Neurotensin-SBI-553
12.12Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
12.12Single8S2TIsoprenaline8S2T-β1-Isoprenaline-chim(NtGi1-Gs)/β1/γ2
12.12Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
12.12Single8XVJMacitentan8XVJ-ETA-Macitentan
12.12Single8XWFCXCL38XWF-CXCR2-CXCL3
12.12Single8ZPLHF511168ZPL-CXCR4-HF51116
12.12Single9AS02-bromo-LSD9AS0-5-HT2A-2-bromo-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
12.12Single9CGJC6-Quino9CGJ-δ-C6-Quino-Gi1/β1/γ2
12.12Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
12.12Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
12.12Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
12.12Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
12.12Consensusfp-alpha_onOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
12.12Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
12.12Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
12.12Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
12.12Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
12.12Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
12.00Single3RFMCaffeine3RFM-A2A-Caffeine
12.00Single6XBM5LWE6XBM-SMO-5LWE-Gi1/β1/γ2
12.00Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.00Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
12.00Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Gi1/β1/γ2
12.00Single9CHUNoradrenaline9CHU-β2-Noradrenaline
12.00Consensusp2y_offOrthosteric Ligandp2y1_off
11.90Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
11.76Single6KNMJN241-96KNM-Apelin-JN241-9
11.76Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
11.76Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
11.76Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
11.76Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
11.76Single7XN9L-054,5227XN9-SST2-L-054,522
11.76Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
11.76Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
11.76Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
11.76Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
11.76Single8X5YAstemizole8X5Y-H1-Astemizole
11.76Single8XQJJN2418XQJ-Apelin-JN241
11.76Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
11.76Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
11.76Single9JH6C20:0 Ceramide9JH6-CysLT2-C20:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
11.76Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
11.76Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
11.54Single3OE6IT1t3OE6-CXCR4-IT1t
11.54Single4XNWMRS25004XNW-P2Y1-MRS2500
11.54Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
11.54Single6ME5Agomelatine6ME5-MT1-Agomelatine
11.54Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
11.54Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
11.54Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
11.54Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
11.54Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
11.54Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
11.54Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
11.54Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
11.54Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
11.54Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
11.54Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
11.54Single9JHJC18:0 Ceramide9JHJ-FPR2-ALX-C18:0 Ceramide-Gi1/β1/γ2
11.54Single9LRCHistamine9LRC-H4-Histamine
11.54Single9LREHistamine9LRE-H4-Histamine-Gi1/β1/γ2
11.54Consensus5ht2_onOrthosteric Ligand5ht2b_on
11.54Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.54Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
11.54Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
11.54Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
11.43Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
11.43Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
11.43Single7F8XNN90567F8X-CCKA-NN9056
11.43Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
11.43Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
11.43Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
11.43Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
11.43Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
11.43Single8KIGSHU91198KIG-MC3-SHU9119-Ca
11.43Single8WKYPG-9348WKY-MC4-PG-934
11.43Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
11.43Single8XWNCXCL88XWN-CXCR2-CXCL8
11.43Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
11.43Single9HB3Mambaquaretin-19HB3-V2-Mambaquaretin-1
11.43Single9J0IUDP-Glucuronic acid9J0I-P2Y14-UDP-Glucuronic acid-Gi1/β1/γ2
11.43Single9M4TSilodosin9M4T-Alpha1A-Silodosin
11.43Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
11.43Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
11.43Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
11.43Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
11.11Single4O9RCyclopamine4O9R-SMO-Cyclopamine
11.11Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
11.11Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
11.11Single7SRQLSD7SRQ-5-HT2B-LSD
11.11Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
11.11Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
11.11Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
11.11Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.11Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
11.11Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
11.11Single8HSCFab0468HSC-GPR20-Fab046-Gi1/β1/γ2
11.11Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
11.11Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
11.11Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
11.11Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
11.11Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
11.11Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
11.11Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
11.11Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
11.11Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
11.11Single8YN7Immethridine8YN7-H3-Immethridine-Go/β1/γ2
11.11Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
11.11Single9AS2DMT9AS2-5-HT2A-DMT-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
11.11Single9IQRMuscarinic toxin 39IQR-α2a-Muscarinic toxin 3
11.11Single9J0FNADH9J0F-P2Y14-NADH-Gi1/β1/γ2
11.11Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
11.11Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
11.11Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
11.11Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg4_on
11.11Consensusadgrg_on_gpOrthosteric Ligandadgrg2_on_gp adgrg4_on_gp
11.11Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
11.11Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
10.81Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
10.81Single8W8YGamma-MSH8W8Y-MC3-γ-MSH-Ca-Gs/β1/γ2
10.81Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
10.81Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
10.71Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
10.71Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
10.71Single4QINSAG1.54QIN-SMO-SAG1.5
10.71Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
10.71Single6B73MP11046B73-κ-MP1104
10.71Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
10.71Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
10.71Single6ME9Ramelteon6ME9-MT2-Ramelteon
10.71Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
10.71Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
10.71Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
10.71Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
10.71Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
10.71Single7BR3Elagolix7BR3-GnRH1-Elagolix
10.71Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
10.71Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
10.71Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
10.71Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.71Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
10.71Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
10.71Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
10.71Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
10.71Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
10.71Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
10.71Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
10.71Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
10.71Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
10.71Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
10.71Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
10.71Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.71Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.71Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.71Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
10.71Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
10.71Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
10.71Single8Y0HVUF114188Y0H-CXCR3-VUF11418
10.71Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go/β1/γ2
10.71Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ2
10.71Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
10.71Single9H2XA1IR19H2X-A2A-A1IR1-Na
10.71Single9K6LSA09K6L-TAS2R16-SA0-Gi2/β1/γ2
10.71Single9KPESA09KPE-TAS2R16-SA0-Gi1/β1/γ2
10.71Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
10.71Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
10.71Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
10.71Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.71Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
10.71Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
10.71Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
10.71Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
10.71Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
10.71Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
10.71Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
10.71Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
10.71Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
10.71Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
10.71Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
10.71Consensusorexin_offOrthosteric Ligandox2_off ox1_off
10.71Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
10.71Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
10.71Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
10.53Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
10.53Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
10.53Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
10.34Single3REYXAC3REY-A2A-XAC
10.34Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
10.34Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
10.34Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
10.34Single4ZJCSB-6740424ZJC-OX1-SB-674042
10.34Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
10.34Single5UVIZM-2413855UVI-A2A-ZM-241385
10.34Single6A94Zotepine6A94-5-HT2A-Zotepine
10.34Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
10.34Single6KUXRS-799486KUX-α2a-RS-79948
10.34Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
10.34Single6TPGEMPA6TPG-OX2-EMPA
10.34Single6V9SGTPL114036V9S-OX1-GTPL11403
10.34Single6VI4JDTic6VI4-κ-JDTic
10.34Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
10.34Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
10.34Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
10.34Single6ZG9GSK10347026ZG9-M1-GSK1034702
10.34Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
10.34Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
10.34Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
10.34Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
10.34Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
10.34Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
10.34Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.34Single7T94Acetylcholine7T94-M2-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
10.34Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
10.34Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
10.34Single7UTZDPPC7UTZ-TSH-TR1402-DPPC-Gs/β1/γ2
10.34Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
10.34Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
10.34Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
10.34Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
10.34Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
10.34Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
10.34Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
10.34Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.34Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.34Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.34Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.34Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
10.34Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
10.34Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
10.34Single8ZPNAMD31008ZPN-CXCR4-AMD3100
10.34Single9AS3LSD9AS3-5-HT2A-LSD
10.34Single9AS4LSD9AS4-5-HT2A-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
10.34Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
10.34Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
10.34Single9KPDSA09KPD-TAS2R16-SA0-chim(Gs-CtGt3)/β1/γ2
10.34Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
10.34Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
10.34Consensusalpha1_onOrthosteric Ligandalpha1a_on
10.34Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
10.34Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
10.34Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
10.34Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
10.34Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
10.34Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
10.34Consensusgrh_offOrthosteric Ligandgnrh1_off
10.34Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
10.26Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
10.26Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.26Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
10.00Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
10.00Single2Y01Dobutamine2Y01-β1-Dobutamine
10.00Single2Y02Carmoterol2Y02-β1-Carmoterol
10.00Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
10.00Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
10.00Single4DAJTiotropium4DAJ-M3-Tiotropium
10.00Single4EJ4Naltrindole4EJ4-δ-Naltrindole
10.00Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
10.00Single4MQSIperoxo4MQS-M2-Iperoxo
10.00Single4QIMANTA XV4QIM-SMO-ANTA XV
10.00Single4U14Tiotropium4U14-M3-Tiotropium
10.00Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
10.00Single5DHGC-355DHG-NOP-C-35
10.00Single5DSGTiotropium5DSG-M4-Tiotropium
10.00Single5T04Neurotensin5T04-NTS1-Neurotensin
10.00Single5TGZAM65385TGZ-CB1-AM6538
10.00Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
10.00Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
10.00Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
10.00Single6DRXLisuride6DRX-5-HT2B-Lisuride
10.00Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
10.00Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
10.00Single6TOTLemborexant6TOT-OX1-Lemborexant
10.00Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
10.00Single7BU7BI1671077BU7-β1-BI167107
10.00Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
10.00Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
10.00Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
10.00Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
10.00Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
10.00Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
10.00Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
10.00Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
10.00Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
10.00Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
10.00Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
10.00Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
10.00Single7YXAONO-54306087YXA-S1P5-ONO-5430608
10.00Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
10.00Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
10.00Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
10.00Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
10.00Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
10.00Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
10.00Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
10.00Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
10.00Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
10.00Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
10.00Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
10.00Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
10.00Single8X63Mepyramine8X63-H1-Mepyramine
10.00Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
10.00Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
10.00Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
10.00Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
10.00Single8YN8Proxyfan8YN8-H3-Proxyfan-Go/β1/γ2
10.00Single8ZYYNeurotensin peptide 8-138ZYY-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
10.00Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
10.00Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
10.00Single9IYAONO-97105319IYA-GPR55-ONO-9710531
10.00Single9JEAAtropine9JEA-M1-Atropine
10.00Single9JGKBalovaptan9JGK-5-HT2B-Balovaptan
10.00Single9PLNN-(5-methylnaphthalen-1-yl)pyridin-4-amine9PLN-α2a-N-(5-methylnaphthalen-1-yl)pyridin-4-amine
10.00Single9PLON-(5-methylnaphthalen-1-yl)pyridin-4-amine9PLO-α2a-N-(5-methylnaphthalen-1-yl)pyridin-4-amine-Go/β1/γ2
10.00Single9PQD(6m)-1-methyl-6-(1,2,5,6-tetrahydropyridin-3-yl)-1h-indole9PQD-α2a-(6m)-1-methyl-6-(1,2,5,6-tetrahydropyridin-3-yl)-1h-indole
10.00Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
10.00Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
10.00Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
10.00Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
10.00Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
10.00Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
10.00Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
10.00Consensusalpha2_onOrthosteric Ligandalpha2b_on
10.00Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
10.00Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
10.00Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
10.00Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
10.00Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
10.00Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
10.00Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
10.00Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
10.00Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
10.00Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
10.00Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
10.00Consensushistamine_offOrthosteric Ligandh1_off
10.00Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
10.00Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
10.00Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
10.00Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
9.76Single8W8WAlpha-MSH8W8W-MC3-α-MSH-Ca-Gs/β1/γ2
9.76Single8W8XBeta-MSH8W8X-MC3-β-MSH-Ca-Gs/β1/γ2
9.68Single2Y00Dobutamine2Y00-β1-Dobutamine
9.68Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
9.68Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
9.68Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
9.68Single5CGCHTL142425CGC-mGlu5-HTL14242
9.68Single5WQCEMPA5WQC-OX2-EMPA
9.68Single5XPRBosentan5XPR-ETB-Bosentan
9.68Single6LUQHaloperidol6LUQ-D2-Haloperidol
9.68Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
9.68Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
9.68Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
9.68Single6TP6Filorexant6TP6-OX1-Filorexant
9.68Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
9.68Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
9.68Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
9.68Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
9.68Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
9.68Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
9.68Single7W41PD1762527W41-BB2-PD176252
9.68Single7WC6LSD7WC6-5-HT2A-LSD
9.68Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
9.68Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.68Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
9.68Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
9.68Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
9.68Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
9.68Single8ZMFA1L108ZMF-5-HT2C-A1L10
9.68Single8ZVZBW245C8ZVZ-DP1-BW245C-Gs/β1/γ2
9.68Single9ARYSerotonin9ARY-5-HT2A-Serotonin-chim(NtGi1-Gs-CtGq)/β1/γ2
9.68Single9ARZ2-bromo-LSD9ARZ-5-HT2A-2-bromo-LSD
9.68Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
9.68Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
9.68Single9DYDAsenapine9DYD-5-HT1A-Asenapine-Go/β1/γ2
9.68Single9DYFAsenapine9DYF-5-HT1A-Asenapine-Gi1/β1/γ2
9.68Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
9.68Single9GE2ML1849GE2-GPR55-ML184-chim(NtGi1-G13)/β1/γ2
9.68Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
9.68Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
9.68Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
9.68Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
9.68Consensusadgrg2_onOrthosteric Ligand7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
9.68Consensusadgrg2_on_gpOrthosteric Ligand7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
9.68Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
9.68Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
9.68Consensusbombesin_offOrthosteric Ligandbb2_off
9.68Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
9.68Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
9.68Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
9.68Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
9.68Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
9.68Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.68Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.38Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
9.38Single4U15Tiotropium4U15-M3-Tiotropium
9.38Single5TZRMK86665TZR-FFA1-MK8666
9.38Single5V54Methiothepin5V54-5-HT1B-Methiothepin
9.38Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
9.38Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
9.38Single6J20Aprepitant6J20-NK1-Aprepitant
9.38Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
9.38Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
9.38Single6OL9Tiotropium6OL9-M5-Tiotropium
9.38Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
9.38Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
9.38Single7R0CAVP7R0C-V2-AVP-Arrestin2
9.38Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
9.38Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
9.38Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
9.38Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
9.38Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
9.38Single8EA0Iperoxo8EA0-M3-Iperoxo
9.38Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
9.38Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.38Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
9.38Single8JD5JNJ-40411813; ADX881788JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
9.38Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
9.38Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
9.38Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
9.38Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
9.38Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
9.38Single9AS9RS130-1809AS9-5-HT2A-RS130-180
9.38Single9ASARS130-1809ASA-5-HT2A-RS130-180-chim(NtGi1-Gs-CtGq)/β1/γ2
9.38Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
9.38Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
9.38Consensus5ht1_offOrthosteric Ligand5ht1b_off
9.38Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
9.38Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
9.38Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
9.38Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
9.38Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
9.38Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
9.38Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
9.38Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
9.38Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
9.38Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
9.38Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
9.09Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
9.09Single4PY02MeSATP4PY0-P2Y12-2MeSATP
9.09Single5CXVTiotropium5CXV-M1-Tiotropium
9.09Single5TZYMK8666; AP85TZY-FFA1-MK8666; AP8
9.09Single5X33BIIL2605X33-BLT1-BIIL260
9.09Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
9.09Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
9.09Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
9.09Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
9.09Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
9.09Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.09Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
9.09Single8XWACXCL18XWA-CXCR2-CXCL1
9.09Single8XWSCXCL58XWS-CXCR2-CXCL5
9.09Single8Y6WTUG-13758Y6W-FFA2-TUG-1375-4-CMTB-Gi1/β1/γ2
9.09Single9AU0BW245C9AU0-DP1-BW245C-Gs/β1/γ2
9.09Single9BJKNAM9BJK-μ-Naloxone-NAM
9.09Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
9.09Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
9.09Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
8.82Single5CGDHTL142425CGD-mGlu5-HTL14242
8.82Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
8.82Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
8.82Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.82Single8T3OTUG-8918T3O-FFA4-TUG-891-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.82Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
8.82Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
8.82Single9GG5U466199GG5-TXA2-U46619-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.82Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
8.57Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
8.57Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
8.57Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.57Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
8.57Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
8.57Single9JF4PD1683689JF4-BB1-PD168368
8.57Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
8.57Consensuskisspeptin_onOrthosteric Ligandkiss1_on
8.33Single5MZPCaffeine5MZP-A2A-Caffeine-Na
8.33Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
8.33Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
8.33Single8IEBA1LYA8IEB-GPR156-A1LYA
8.33Single8IEIA1LYA8IEI-GPR156-A1LYA
8.33Single8IEPA1LYA8IEP-GPR156-A1LYA
8.33Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
8.33Single8ZBJSomatostatin-148ZBJ-SST5-Somatostatin-14-Gi1/β1/γ2
8.33Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
8.33Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
8.33Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
8.33Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
8.11Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
8.11Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
8.11Single9IK8SST analogue9IK8-SST1-SST analogue-Gi1/β1/γ2
8.11Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
8.00Single7V68LY21196207V68-M4-Iperoxo-LY2119620-Gi1/β1/γ2
7.89Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
7.89Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
7.89Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
7.69Single3OE8IT1t3OE8-CXCR4-IT1t
7.69Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
7.69Single6TQ9SB-4081246TQ9-OX1-SB-408124
7.69Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
7.69Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
7.69Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
7.69Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
7.69Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
7.69Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
7.69Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
7.69Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
7.41Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
7.41Single3UZAGTPL92363UZA-A2A-GTPL9236
7.41Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
7.41Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
7.41Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
7.41Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
7.41Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
7.41Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
7.41Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.41Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
7.41Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
7.41Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
7.41Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
7.41Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
7.41Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
7.41Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
7.41Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
7.41Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
7.41Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
7.41Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
7.14Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
7.14Single3PBLEticlopride3PBL-D3-Eticlopride
7.14Single5L7IVismodegib5L7I-SMO-Vismodegib
7.14Single6HLLCP999946HLL-NK1-CP99994
7.14Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
7.14Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
7.14Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
7.14Single7V68Iperoxo7V68-M4-Iperoxo-LY2119620-Gi1/β1/γ2
7.14Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
7.14Single7XP6Strychnine7XP6-TAS2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
7.14Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
7.14Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
7.14Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
7.14Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
7.14Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
7.14Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
7.14Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
7.14Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
7.14Single9AS7Psilocin9AS7-5-HT2A-Psilocin
7.14Single9E7RGB889E7R-PAR2-GB88-chim(NtGi1L-Gs-CtGq)/β1/γ2
7.14Single9IXJHistamine9IXJ-H2-Histamine-Gs/β1/γ2
7.14Single9IZDCHBA9IZD-HCA1-CHBA-Gi1/β1/γ2
7.14Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
7.14Consensusgq_nucleotideOrthosteric Ligandgq_p2y
7.14Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
7.14Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
6.90Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
6.90Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
6.90Single4S0VSuvorexant4S0V-OX2-Suvorexant
6.90Single5WS3EMPA5WS3-OX2-EMPA
6.90Single6DS0Ly2660976DS0-5-HT2B-Ly266097
6.90Single6TODEMPA6TOD-OX1-EMPA-Na
6.90Single6TPJSuvorexant6TPJ-OX2-Suvorexant
6.90Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
6.90Single7F8ULintitript7F8U-CCKA-Lintitript
6.90Single7F8YDevazepide7F8Y-CCKA-Devazepide
6.90Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
6.90Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.90Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
6.90Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
6.90Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
6.90Single7XRRLemborexant7XRR-OX2-Lemborexant
6.90Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.90Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
6.90Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.90Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.90Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
6.90Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
6.90Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
6.90Single9LRBHistamine9LRB-H1-Histamine-Gs/β1/γ2
6.90Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
6.90Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
6.90Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
6.67Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
6.67Single3RZECidoxepin3RZE-H1-Cidoxepin
6.67Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
6.67Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
6.67Single6IQLL7458706IQL-D4-L745870
6.67Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
6.67Single6TP3Nemorexant6TP3-OX1-Nemorexant
6.67Single6TPNHTL66416TPN-OX2-HTL6641
6.67Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
6.67Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
6.67Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
6.67Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
6.67Single7VV6C48/807VV6-MRGPRX2-C48/80
6.67Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
6.67Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.67Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
6.67Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
6.67Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
6.67Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
6.67Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
6.67Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
6.67Single8YRGFospropofol8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
6.67Single9ARXSerotonin9ARX-5-HT2A-Serotonin
6.67Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67Single9IXXLTD49IXX-CysLT2-LTD4-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Gi1/β1/γ2
6.67Single9LRDHistamine9LRD-H1-Histamine-Gi1/β1/γ2
6.67Consensusopsins_offOrthosteric Ligandrhodopsin_off
6.67Consensussensory_offOrthosteric Ligandopsins_off
6.45Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
6.45Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
6.45Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
6.45Single6IIVDaltroban6IIV-TXA2-Daltroban
6.45Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.45Single7F83PF-051904577F83-Ghrelin-PF-05190457
6.45Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
6.45Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
6.45Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
6.45Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
6.45Single8X64Desloratadine8X64-H1-Desloratadine
6.45Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
6.45Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
6.45Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
6.45Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
6.45Consensuscck_offOrthosteric Ligandccka_off
6.45Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
6.25Single4NTJAZD12834NTJ-P2Y12-AZD1283
6.25Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
6.25Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
6.25Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
6.25Single7SINNPS-21437SIN-CaS-NPS-2143
6.25Single7SINNPS-21437SIN-CaS-NPS-2143
6.25Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
6.25Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
6.25Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
6.25Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
6.25Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
6.25Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
6.25Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
6.25Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
6.25Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
6.25Single9HAPTolvaptan9HAP-V2-Tolvaptan
6.25Single9HC04YI9HC0-mGlu5-4YI
6.06Single6E59L-7607356E59-NK1-L-760735
6.06Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
6.06Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
6.06Single7P2L4YI7P2L-mGlu5-4YI
6.06Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
6.06Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
6.06Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
6.06Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
6.06Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Gi1/β1/γ1
6.06Single8XVLZibotentan8XVL-ETA-Zibotentan
6.06Single8ZW0PGD28ZW0-DP1-PGD2-Gs/β1/γ2
6.06Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
6.06Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
6.06Consensustachykinin_offOrthosteric Ligandnk1_off
5.88Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
5.88Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
5.88Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
5.88Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.88Single8JD3JNJ-404118138JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
5.88Single9CM3TUG-13759CM3-FFA2-TUG-1375-Compound 187-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.88Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
5.88Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
5.71Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
5.71Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
5.71Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
5.71Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
5.71Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
5.56Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
5.56Single9CM7TUG-13759CM7-FFA2-TUG-1375-AZ-1729-Gi1/β1/γ2
5.56Single9NS9TUG-13759NS9-FFA2-TUG-1375-Compound 187-Gi1/β1/γ2
5.41Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
5.41Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.41Single8IEIA1LYA8IEI-GPR156-A1LYA
5.41Single8IEPA1LYA8IEP-GPR156-A1LYA
5.41Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
5.26Single8IEBA1LYA8IEB-GPR156-A1LYA
4.55Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
4.55Single6D35Cholesterol6D35-SMO-Cholesterol
4.55Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
4.55Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
4.55Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
4.55Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
4.55Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042
4.55Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042
4.55Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042
4.55Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-BHFF
4.55Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
4.55Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626
4.55Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
4.55Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
4.55Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
4.55Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
4.55Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
4.55Single7DTTCa7DTT-CaS-Ca-Ca
4.55Single7DTTCa7DTT-CaS-Ca-Ca
4.55Single7DTUTryptophan7DTU-CaS-Tryptophan
4.55Single7DTUTryptophan7DTU-CaS-Tryptophan
4.55Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
4.55Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
4.55Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
4.55Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
4.55Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.55Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.55Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.55Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.55Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
4.55Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
4.55Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
4.55Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
4.55Single7EB2Baclofen7EB2-GABAB2; GABAB1-Baclofen-rac-BHFF-Gi1/β1/γ2
4.55Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
4.55Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
4.55Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
4.55Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
4.55Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
4.55Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
4.55Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
4.55Single7FIIhCG7FII-LH-hCG-chim(NtGi1-Gs)/β1/γ2
4.55Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
4.55Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
4.55Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
4.55Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
4.55Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.55Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.55Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.55Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.55Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
4.55Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
4.55Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
4.55Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
4.55Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
4.55Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
4.55Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
4.55Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
4.55Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
4.55Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
4.55Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.55Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.55Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.55Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.55Single7T9NM22 Fab7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
4.55Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
4.55Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
4.55Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
4.55Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
4.55Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
4.55Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
4.55Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
4.55Single7XW7K1-707XW7-TSH-K1-70
4.55Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
4.55Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
4.55Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
4.55Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
4.55Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
4.55Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
4.55Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
4.55Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
4.55Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
4.55Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
4.55Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
4.55Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
4.55Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-NAM563
4.55Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
4.55Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
4.55Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
4.55Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
4.55Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
4.55Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
4.55Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
4.55Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
4.55Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
4.55Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
4.55Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
4.55Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
4.55Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
4.55Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
4.55Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
4.55Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
4.55Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
4.55Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
4.55Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
4.55Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
4.55Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
4.55Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
4.55Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
4.55Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
4.55Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
4.55Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
4.55Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
4.55Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
4.55Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
4.55Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
4.55Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
4.55Single8WG9(2S)-2-amino-4-phosphonobutanoic acid8WG9-mGlu4; mGlu2-(2S)-2-amino-4-phosphonobutanoic acid
4.55Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
4.55Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
4.55Single8WGCLY3792688WGC-mGlu4; mGlu2-LY379268
4.55Single8WGDWAG; WA68WGD-mGlu4; mGlu2-WAG; WA6
4.55Single8WGDWAG; WA68WGD-mGlu4; mGlu2-WAG; WA6
4.55Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
4.55Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
4.55Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.55Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.55Single8WVXNorrin8WVX-LGR4-Norrin
4.55Single8WVYNorrin8WVY-LGR4-Norrin
4.55Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
4.55Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
4.55Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
4.55Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
4.55Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
4.55Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
4.55Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
4.55Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
4.55Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
4.55Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
4.55Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
4.55Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
4.55Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
4.55Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
4.55Single8XUMR-spondin-28XUM-LGR4-R-spondin-2
4.55Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
4.55Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
4.55Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
4.55Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
4.55Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
4.55Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
4.55Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
4.55Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
4.55Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
4.55Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
4.55Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
4.55Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
4.55Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
4.55Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
4.55Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
4.55Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
4.55Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
4.55Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
4.55Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
4.55Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
4.55Single9KHHNorrin9KHH-LGR4-Norrin
4.55Single9S37NB219S37-LGR4-NB21
4.55Single9UTBSucralose9UTB-TAS1R2; TAS1R3-Sucralose
4.35Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.35Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.35Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.35Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.35Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.35Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.35Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.35Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.35Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
4.35Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
4.35Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
4.35Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
4.35Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
4.35Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
4.35Consensusclass-b2_onOrthosteric Ligandadgrg_on adgrf_on adgrl_on adgre_on adgrd_on
4.35Consensusclass-b2_on_gpOrthosteric Ligandadgrg_on_gp adgrf_on_gp adgrl_on_gp adgre_on_gp adgrd_on_gp
4.17Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
4.17Single7T9MCS-17 Antibody7T9M-TSH-CS-17 Antibody
4.17Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
4.17Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
4.00Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
4.00Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/β1/γ2
4.00Single7UTZTR14027UTZ-TSH-TR1402-DPPC-Gs/β1/γ2
4.00Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/β1/γ2
4.00Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
4.00Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
3.85Single5L7DCholesterol5L7D-SMO-Cholesterol
3.85Single6VCBLSN31604406VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
3.85Single7T9ITSH7T9I-TSH-TSH-Gs/β1/γ2
3.85Single7WC4Serotonin7WC4-5-HT2A-Serotonin
3.85Single8I2GGlycoprotein hormones alpha chain8I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
3.70Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
3.70Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
3.70Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
3.70Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
3.70Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
3.70Single8Y02Retinal8Y02-OPN1SW-Retinal-Gi1/β1/γ2
3.70Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
3.70Single9IVMLSN33188399IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
3.70Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
3.70Consensussensory_onOrthosteric Ligandopsins_on
3.57Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
3.57Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
3.57Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
3.57Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
3.57Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/β1/γ2
3.57Single7WC5Psilocin7WC5-5-HT2A-Psilocin
3.57Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
3.57Single8JPSCCL78JPS-ACKR1-CCL7
3.57Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
3.57Consensusgi_sensoryOrthosteric Ligandgi_opsins
3.57Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
3.57Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
3.57Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
3.57Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
3.57Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
3.45Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
3.45Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
3.45Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
3.45Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
3.45Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
3.45Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
3.45Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
3.45Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
3.45Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
3.45Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
3.45Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
3.45Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
3.45Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
3.45Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.45Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
3.45Single7UL2SR486927UL2-NTS1-SR48692-Na
3.45Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.45Single8ZYUNeurotensin peptide 8-138ZYU-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
3.45Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
3.45Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
3.45Consensusneurotensin_offOrthosteric Ligandnts1_off
3.45Consensusnts1_offOrthosteric Ligand7UL2-NTS1-SR48692-Na
3.33Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
3.33Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
3.33Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
3.33Single4XNVBPTU4XNV-P2Y1-BPTU
3.33Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
3.33Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
3.33Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
3.33Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
3.33Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
3.33Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
3.33Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
3.33Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
3.33Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
3.33Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
3.33Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
3.33Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
3.33Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
3.33Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
3.33Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
3.33Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
3.23Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
3.23Single6FFIMMPEP6FFI-mGlu5-MMPEP
3.23Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
3.23Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
3.23Single6TPKRetosiban6TPK-OT-Retosiban
3.23Single6ZINSR486926ZIN-NTS1-SR48692
3.23Single7VODCariprazine7VOD-5-HT2A-Cariprazine
3.23Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
3.23Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
3.23Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
3.23Single8IYXYL-3658IYX-GPR34-YL-365
3.23Single8JD6VU03647708JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
3.23Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.23Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
3.23Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
3.23Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
3.23Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
3.23Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
3.23Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
3.23Consensusvasop-oxy_offOrthosteric Ligandot_off
3.12Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
3.12Single6FFHFenobam6FFH-mGlu5-Fenobam
3.12Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
3.03Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
3.03Single6HLPNetupitant6HLP-NK1-Netupitant
3.03Single6Z4SSR486926Z4S-NTS1-SR48692
3.03Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
3.03Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
3.03Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
3.03Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
3.03Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
2.94Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
2.94Single8JD5JNJ-40411813; ADX881788JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
2.94Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
2.94Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
2.94Single9CLWTUG-13759CLW-FFA2-TUG-1375-4-CMTB-chim(NtGi1L-Gs-CtGq)/β1/γ2
2.63Single8XFTR-spondin-28XFT-LGR4-R-spondin-2-ZNRF3
2.63Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-ZNRF3
2.50Single8WVUR-spondin-18WVU-LGR4-R-spondin-1-RNF43
2.50Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-ZNRF3
2.44Single8XFPR-spondin-28XFP-LGR4-R-spondin-2-ZNRF3
2.27Single8XFSR-spondin-28XFS-LGR4-R-spondin-2-ZNRF3

Consensus Members
Id Members
vpac1_on_gp 8E3Z-VPAC1-VIP-Gs/β1/γ2
vpac2_on_gp 7VQX-VPAC1-PACAP27-Gs/β1/γ2
Net Summary
Imin 3.385
Number of Linked Nodes 861
Number of Links 1044
Number of Hubs 166
Number of Links mediated by Hubs 636
Number of Communities 27
Number of Nodes involved in Communities 217
Number of Links involved in Communities 310
Path Summary
Number Of Nodes in MetaPath 120
Number Of Links MetaPath 119
Number of Shortest Paths 1231458
Length Of Smallest Path 3
Average Path Length 29.2621
Length of Longest Path 54
Minimum Path Strength 0.7625
Average Path Strength 6.58005
Maximum Path Strength 42.475
Minimum Path Correlation 0.7
Average Path Correlation 0.98701
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.17391
Average % Of Corr. Nodes 52.6705
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 49.1432
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following consensuses:
IdComponents
vip-pacap_on_gpvpac_on_gp
pac_on_gp



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