Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:H41 8.4175406
2A:A:K53 6.061676209
3A:A:G206 3.11438
4A:A:F219 6.77333668
5A:A:M221 3.468508
6A:A:F222 12.6225427
7A:A:Q227 6.2775439
8A:A:K233 6.09639
9A:A:W234 6.592509
10A:A:C237 6.4375428
11A:A:F238 8.864529
12A:A:F246 5.5725409
13A:A:Q267 4.8625404
14A:A:F273 5.16254159
15A:A:W277 9.883336156
16A:A:W281 10.94625
17A:A:F290 5.79254229
18A:A:N292 5.48509
19A:A:K293 3.7275409
20A:A:F312 5.478336148
21A:A:E314 5.3545146
22A:A:F315 9.5025146
23A:A:Y318 7.865146
24A:A:E330 7.5985113
25A:A:D331 5.20754234
26A:A:K338 10.58254115
27A:A:Y339 6.771676113
28A:A:F340 10.455147
29A:A:R342 6.0225114
30A:A:E344 8.2285145
31A:A:F345 8.7025408
32A:A:S349 3.985407
33A:A:S352 4.2254155
34A:A:R356 7.721676152
35A:A:Y358 7.505404
36A:A:Y360 10.5525408
37A:A:F363 9.3165115
38A:A:N371 6.39754229
39A:A:R373 5.668565
40A:A:F376 7.15833668
41A:A:R385 10.745465
42A:A:Y391 7.27404
43A:A:L393 3.3825408
44B:B:T34 4.4985125
45B:B:I37 5.68254122
46B:B:V40 5.445123
47B:B:H54 10.468519
48B:B:K57 10.736529
49B:B:Y59 11.19428
50B:B:M61 4.595416
51B:B:W63 7.676517
52B:B:Q75 12429
53B:B:D76 6.384519
54B:B:I81 5.61487
55B:B:W82 10.635619
56B:B:D83 10.695418
57B:B:Y85 14.9675414
58B:B:K89 5.805619
59B:B:L95 4.642588
60B:B:W99 10.76529
61B:B:Y105 5.12375886
62B:B:L117 5.92429
63B:B:Y124 5.17586
64B:B:L126 4.185485
65B:B:V133 6.495484
66B:B:H142 7.51667639
67B:B:Y145 6.055638
68B:B:F151 5.34833609
69B:B:I157 5.04407
70B:B:T159 6.0875439
71B:B:D163 9.8475439
72B:B:W169 9.33333638
73B:B:I171 3.8925406
74B:B:F180 8.204597
75B:B:H183 9.005699
76B:B:D186 6.6225439
77B:B:V187 4.3375499
78B:B:F199 8.3425499
79B:B:V200 5.93456
80B:B:S201 4.915499
81B:B:C204 5.22333637
82B:B:D205 7.33499
83B:B:K209 12.1325496
84B:B:W211 9.02333698
85B:B:Q220 6.07457
86B:B:F222 8.28458
87B:B:H225 9.91333659
88B:B:D228 8.168539
89B:B:I232 4.705458
90B:B:F234 5.072505
91B:B:F235 8.116676176
92B:B:P236 8.18254177
93B:B:F241 7.964556
94B:B:T243 4.585458
95B:B:D246 7.55439
96B:B:D247 8.362559
97B:B:R251 11.2383658
98B:B:F253 6.63333656
99B:B:D258 8.904557
100B:B:E260 6.765456
101B:B:M262 6.79404
102B:B:Y264 8.2275405
103B:B:I269 3.8625424
104B:B:F278 5.7725177
105B:B:R283 8.615129
106B:B:L284 5.49754125
107B:B:L285 5.5125406
108B:B:Y289 7.09143727
109B:B:D290 6.25426
110B:B:N295 9.0375426
111B:B:V296 4.69405
112B:B:W297 6.6975428
113B:B:R304 7.7075425
114B:B:H311 8.2985139
115B:B:R314 13.65528
116B:B:L318 4.22406
117B:B:W332 9.26571729
118B:B:D333 9.154139
119B:B:L336 4.8825417
120B:B:K337 7.4985136
121B:B:W339 10.345139
122B:B:N340 4.565409
123G:G:R13 3.3575406
124G:G:V16 4.754247
125G:G:R27 7.91458
126G:G:Y40 10.15754176
127G:G:D48 6.69509
128G:G:L51 4.138336126
129G:G:F61 4.81714718
130L:L:C2 6.0925470
131L:L:T4 4.37570
132L:L:T6 6.78470
133L:L:C7 5.9225470
134L:L:L16 4.83754100
135L:L:F23 5.051676100
136L:L:T36 4.255440
137L:L:P37 6.8175440
138L:L:?38 8.585440
139R:R:R45 4.545407
140R:R:K47 7.4025404
141R:R:R58 7.60754183
142R:R:W76 9.7554188
143R:R:D77 6.76833649
144R:R:W79 9.568546
145R:R:L80 8.9575445
146R:R:W82 11.365649
147R:R:Y98 12.2475404
148R:R:F99 14.36445
149R:R:D101 6.685404
150R:R:F102 9.09833644
151R:R:V108 6.0475447
152R:R:Y111 4.5275404
153R:R:G116 2.4825449
154R:R:W118 9.82333649
155R:R:S129 5.894547
156R:R:Y131 9.94333645
157R:R:F137 6.4925401
158R:R:Y149 5.386105
159R:R:T162 4.4954196
160R:R:L163 4.235408
161R:R:F173 7.9885297
162R:R:Q179 7.174217
163R:R:V181 5.6175409
164R:R:L183 4.345408
165R:R:F188 5.025408
166R:R:Y191 9.56667678
167R:R:V206 3.6554103
168R:R:Y234 10.798577
169R:R:W236 8.836309
170R:R:M237 5.776579
171R:R:L238 5.8225408
172R:R:E240 6.58409
173R:R:Y243 7.96218
174R:R:H245 12.13254328
175R:R:F253 7.61333666
176R:R:Q257 9.845215
177R:R:L259 7.115405
178R:R:Y262 6.45754217
179R:R:P270 3.935319
180R:R:H277 7.3325407
181R:R:R281 8.983336167
182R:R:F285 9.10254166
183R:R:D287 4.28754163
184R:R:W290 7.333336169
185R:R:L291 5.52254276
186R:R:L297 5.83254164
187R:R:L298 3.4675476
188R:R:H302 5.75571776
189R:R:K326 7.6975469
190R:R:M327 4.628507
191R:R:I354 5.7406
192R:R:Q355 7.9475478
193R:R:F356 6.66143777
194R:R:P363 5.47407
195R:R:Y372 7.0145337
196R:R:Y374 6.01754106
197R:R:M376 4.3325407
198R:R:H381 7.708509
199R:R:Q383 10.0725479
200R:R:F385 7.744195
201R:R:C392 6.09254199
202R:R:F393 4.30254198
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:D76 B:B:K78 15.06635.53YesNo098
2A:A:Y37 B:B:L55 10.25653.52NoNo046
3A:A:R42 A:A:Y37 10.532225.72NoNo094
4A:A:H41 A:A:I383 31.43887.95YesNo068
5A:A:H387 A:A:I383 31.66893.98NoNo088
6A:A:H387 R:R:L247 32.357719.28NoNo088
7R:R:L247 R:R:Y243 33.00749.38NoYes088
8A:A:Y391 R:R:Y243 24.20043.97YesYes048
9A:A:Y391 R:R:R180 28.320813.38YesNo049
10R:R:C178 R:R:R180 30.04825.57NoNo089
11R:R:C178 R:R:V181 30.06313.42NoYes089
12R:R:F170 R:R:V181 30.497510.49NoYes089
13R:R:C392 R:R:F170 97.65366.98YesNo098
14R:R:C392 R:R:I169 99.56064.91YesNo098
15R:R:F173 R:R:I169 99.58963.77YesNo078
16R:R:F173 R:R:L176 99.5257.31YesNo2979
17R:R:L176 R:R:V398 99.7875.96NoNo099
18R:R:N395 R:R:V398 99.81447.39NoNo099
19R:R:E397 R:R:N395 99.86855.26NoNo099
20R:R:E397 R:R:N396 99.89525.26NoNo096
21R:R:N396 R:R:T400 99.97412.92NoNo064
22R:R:R404 R:R:T400 1003.88NoNo074
23B:B:F292 R:R:R404 91.50693.21NoNo047
24B:B:F292 B:B:N313 91.51533.62NoNo047
25B:B:N313 B:B:W332 91.53164.52NoYes079
26B:B:S316 B:B:W332 24.08634.94NoYes099
27B:B:C317 B:B:S316 23.93343.44NoNo079
28B:B:C317 B:B:M61 23.78784.86NoYes076
29B:B:M61 B:B:W63 12.31164.65YesYes167
30B:B:S84 B:B:W63 11.10274.94NoYes157
31B:B:R68 B:B:Y85 12.302530.87NoYes054
32B:B:L70 B:B:M61 11.17375.65NoYes156
33B:B:L70 B:B:W82 11.44376.83NoYes159
34A:A:H41 R:R:F253 30.25827.92YesYes066
35A:A:F222 A:A:R42 11.66993.21YesNo079
36A:A:D368 A:A:N371 13.596212.12NoYes099
37A:A:D368 A:A:R374 14.32493.57NoNo094
38A:A:E370 A:A:R374 22.95444.65NoNo044
39A:A:E370 A:A:R373 23.19026.98NoYes045
40A:A:F376 A:A:R373 23.32474.28YesYes685
41A:A:F376 R:R:F253 24.227712.86YesYes686
42A:A:N292 A:A:T364 12.96585.85YesNo099
43A:A:F222 B:B:W99 12.899421.05YesYes279
44B:B:M101 B:B:Y145 17.94337.18NoYes098
45A:A:C237 B:B:M101 18.3494.86YesNo089
46A:A:C237 B:B:Y59 21.03245.38YesYes288
47B:B:W332 B:B:Y59 29.42164.82YesYes298
48A:A:W281 B:B:W332 43.02414.69YesYes259
49B:B:R314 B:B:W332 25.818422.99YesYes289
50A:A:S352 A:A:W277 11.06454.94YesYes1556
51A:A:R356 A:A:S352 11.6045.27YesYes1525
52A:A:R283 A:A:R356 23.372514.93NoYes032
53A:A:K280 A:A:R283 23.51544.95NoNo053
54A:A:K280 A:A:W281 23.659412.76NoYes055
55A:A:H357 A:A:W277 11.064735.97NoYes1576
56A:A:H357 A:A:R356 11.17947.9NoYes1572
57A:A:S349 A:A:W277 12.75626.18YesYes076
58A:A:L346 A:A:S349 11.4943NoYes047
59A:A:L346 A:A:R342 10.99417.29NoYes1144
60A:A:W281 B:B:D290 28.07637.82YesYes256
61B:B:D290 B:B:R314 24.648810.72YesYes268
62B:B:C271 B:B:D290 52.16773.11NoYes256
63B:B:C271 B:B:Y289 50.69614.03NoYes257
64B:B:W297 B:B:Y289 46.77464.82YesYes287
65B:B:W297 B:B:Y264 46.460411.58YesYes085
66B:B:L285 B:B:Y264 44.89014.69YesYes065
67B:B:F278 B:B:L285 43.65519.74YesYes076
68B:B:F235 B:B:F278 41.09497.5YesYes1767
69B:B:F235 B:B:N237 38.892912.08YesNo1765
70B:B:N237 B:B:N239 38.643912.26NoNo052
71B:B:N239 B:B:R256 38.331614.46NoNo029
72B:B:R256 G:G:I28 37.393410.02NoNo094
73G:G:A33 G:G:I28 37.08023.25NoNo074
74B:B:D254 G:G:A33 36.76684.63NoNo097
75B:B:A257 B:B:D254 36.13954.63NoNo079
76B:B:A257 B:B:Q259 35.82553.03NoNo076
77B:B:Q259 B:B:R22 34.88225.84NoNo066
78B:B:D258 B:B:R22 25.986914.29YesNo076
79B:B:D312 R:R:R404 10.50774.76NoNo057
80B:B:D312 B:B:D333 10.32723.99NoYes059
81B:B:L69 B:B:Y105 11.13743.52NoYes056
82B:B:I93 B:B:P94 12.19323.39NoNo075
83B:B:G162 B:B:Y145 14.16437.24NoYes398
84B:B:G162 B:B:S161 14.12333.71NoNo399
85B:B:H142 B:B:S161 12.931613.95YesNo399
86B:B:H142 B:B:W169 11.97877.41YesYes398
87B:B:I157 B:B:W169 10.22513.52YesYes078
88B:B:D258 B:B:F222 13.83633.58YesYes578
89B:B:D258 B:B:Q220 10.53979.14YesYes577
90B:B:L210 B:B:Q220 10.23093.99NoYes057
91R:R:F170 R:R:F188 67.47826.43NoYes088
92R:R:F188 R:R:V387 66.80563.93YesNo089
93R:R:V387 R:R:Y191 66.76476.31NoYes098
94R:R:M237 R:R:Y191 17.30355.99YesYes798
95R:R:M237 R:R:Y234 29.63284.79YesYes797
96L:L:T6 R:R:Y234 11.00038.74YesYes707
97L:L:T6 R:R:H302 19.76068.21YesYes706
98R:R:H302 R:R:L298 27.33873.86YesYes766
99R:R:H277 R:R:L298 20.15483.86YesYes076
100R:R:H277 R:R:R281 14.242413.54YesYes077
101R:R:Q383 R:R:Y191 53.888614.65YesYes798
102R:R:F356 R:R:Q383 61.41114.68YesYes779
103L:L:T6 R:R:F356 11.18463.89YesYes707
104R:R:F356 R:R:I380 62.83386.28YesNo076
105R:R:H381 R:R:I380 59.63883.98YesNo096
106R:R:H377 R:R:H381 57.5399.55NoYes079
107L:L:L12 R:R:H377 56.24836.43NoNo1007
108L:L:L12 L:L:L16 56.18964.15NoYes1000
109L:L:F23 L:L:L16 54.47878.53YesYes1000
110L:L:F23 R:R:Y146 52.86943.09YesNo002
111R:R:L142 R:R:Y146 52.672211.72NoNo022
112L:L:F15 R:R:L142 52.47484.87NoNo002
113L:L:F15 L:L:S19 51.48459.25NoNo000
114L:L:S19 R:R:T138 51.0873.2NoNo002
115R:R:D101 R:R:T138 50.68864.34YesNo042
116R:R:D101 R:R:N135 27.715512.12YesNo043
117L:L:T30 R:R:D101 22.57488.67NoYes004
118L:L:T30 R:R:F99 22.365316.86NoYes005
119R:R:F99 R:R:W79 17.469914.03YesYes456
120R:R:F102 R:R:N135 26.66587.25YesNo043
121R:R:F102 R:R:W79 17.6716.01YesYes446
122R:R:W79 R:R:Y131 19.420713.5YesYes465
123R:R:S129 R:R:Y131 11.76485.09YesYes475
124R:R:M48 R:R:R45 10.154511.17NoYes067
125R:R:K110 R:R:S129 10.47016.12NoYes487
126R:R:K110 R:R:W118 10.11920.89NoYes489
127R:R:L183 R:R:Y243 20.90954.69YesYes088
128R:R:E240 R:R:L183 22.66373.98YesYes098
129R:R:M187 R:R:Y191 10.64028.38NoYes788
130R:R:E240 R:R:M187 29.15669.47YesNo098
131B:B:K78 B:B:P94 12.76476.69NoNo085
132B:B:Q75 B:B:W99 16.39656.57YesYes299
133B:B:I93 B:B:Y124 10.64459.67NoYes876
134R:R:M187 R:R:M237 18.72024.33NoYes789
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?0 R:R:H296 10.37 0 No No 0 2 0 1
L:L:K1 R:R:E294 12.15 0 No No 0 3 0 1
L:L:C2 R:R:L298 3.17 7 Yes Yes 0 6 0 1
L:L:C2 R:R:H302 8.85 7 Yes Yes 0 6 0 1
L:L:T4 R:R:H302 4.11 7 Yes Yes 0 6 0 1
L:L:T4 R:R:M306 3.01 7 Yes No 0 4 0 1
L:L:T6 R:R:Y234 8.74 7 Yes Yes 0 7 0 1
L:L:T6 R:R:H302 8.21 7 Yes Yes 0 6 0 1
L:L:T6 R:R:F356 3.89 7 Yes Yes 0 7 0 1
L:L:C7 R:R:H302 8.85 7 Yes Yes 0 6 0 1
L:L:A8 R:R:M376 3.22 0 No Yes 0 7 0 1
L:L:T9 R:R:H381 5.48 0 No Yes 0 9 0 1
L:L:L12 R:R:L148 6.92 10 No No 0 5 0 1
L:L:L12 R:R:H377 6.43 10 No No 0 7 0 1
L:L:E14 R:R:L291 3.98 27 No Yes 0 6 0 1
L:L:E14 R:R:V293 4.28 27 No No 0 6 0 1
L:L:F15 R:R:K141 16.13 0 No No 0 3 0 1
L:L:F15 R:R:L142 4.87 0 No No 0 2 0 1
L:L:L16 R:R:A145 3.15 10 Yes No 0 4 0 1
L:L:L16 R:R:Y149 3.52 10 Yes Yes 0 5 0 1
L:L:R17 R:R:L291 7.29 27 No Yes 0 6 0 1
L:L:S19 R:R:T138 3.2 0 No No 0 2 0 1
L:L:F23 R:R:Y146 3.09 10 Yes No 0 2 0 1
L:L:F23 R:R:Y149 5.16 10 Yes Yes 0 5 0 1
L:L:F23 R:R:V206 5.24 10 Yes Yes 0 3 0 1
L:L:F23 R:R:P207 4.33 10 Yes No 0 3 0 1
L:L:T30 R:R:F99 16.86 0 No Yes 0 5 0 1
L:L:T30 R:R:D101 8.67 0 No Yes 0 4 0 1
L:L:V32 R:R:T132 4.76 0 No No 0 6 0 1
L:L:S34 R:R:H121 8.37 28 No No 0 4 0 1
L:L:S34 R:R:E123 5.75 28 No No 0 4 0 1
L:L:S34 R:R:N124 2.98 28 No No 0 5 0 1
L:L:P37 R:R:D77 4.83 4 Yes Yes 0 9 0 1
L:L:P37 R:R:W79 10.81 4 Yes Yes 0 6 0 1
L:L:?38 R:R:D77 10.08 4 Yes Yes 0 9 0 1
L:L:?38 R:R:S129 7.43 4 Yes Yes 0 7 0 1
L:L:?38 R:R:Y131 8.7 4 Yes Yes 0 5 0 1
L:L:?101 R:R:Y299 28.45 0 No No 0 7 0 1
R:R:M48 R:R:W79 3.49 0 No Yes 6 6 2 1
R:R:M48 R:R:Y98 10.78 0 No Yes 6 4 2 2
R:R:D77 R:R:G78 5.03 4 Yes No 9 5 1 2
R:R:D77 R:R:W82 5.58 4 Yes Yes 9 9 1 2
R:R:D77 R:R:S129 5.89 4 Yes Yes 9 7 1 1
R:R:D77 R:R:Y131 9.2 4 Yes Yes 9 5 1 1
R:R:F99 R:R:W79 14.03 4 Yes Yes 5 6 1 1
R:R:F102 R:R:W79 6.01 4 Yes Yes 4 6 1 1
R:R:W79 R:R:Y131 13.5 4 Yes Yes 6 5 1 1
R:R:L80 R:R:P96 11.49 4 Yes No 5 9 2 2
R:R:L80 R:R:V108 4.47 4 Yes Yes 5 7 2 2
R:R:L80 R:R:Y131 10.55 4 Yes Yes 5 5 2 1
R:R:V108 R:R:W82 3.68 4 Yes Yes 7 9 2 2
R:R:K110 R:R:W82 34.81 4 No Yes 8 9 2 2
R:R:S129 R:R:W82 4.94 4 Yes Yes 7 9 1 2
R:R:P96 R:R:Y98 15.3 0 No Yes 9 4 2 2
R:R:F102 R:R:P96 5.78 4 Yes No 4 9 1 2
R:R:F99 R:R:Y98 6.19 4 Yes Yes 5 4 1 2
R:R:F102 R:R:F99 20.36 4 Yes Yes 4 5 1 1
R:R:D101 R:R:N135 12.12 0 Yes No 4 3 1 1
R:R:D101 R:R:T138 4.34 0 Yes No 4 2 1 1
R:R:C134 R:R:F102 12.57 0 No Yes 9 4 2 1
R:R:F102 R:R:N135 7.25 4 Yes No 4 3 1 1
R:R:D103 R:R:K141 11.06 0 No No 3 3 2 1
R:R:V108 R:R:Y131 12.62 4 Yes Yes 7 5 2 1
R:R:K110 R:R:S129 6.12 4 No Yes 8 7 2 1
R:R:H121 R:R:P122 7.63 0 No No 4 5 1 2
R:R:H121 R:R:W128 17.98 0 No No 4 5 1 2
R:R:E123 R:R:N124 10.52 28 No No 4 5 1 1
R:R:N130 R:R:W128 9.04 0 No No 8 5 2 2
R:R:S129 R:R:Y131 5.09 4 Yes Yes 7 5 1 1
R:R:N130 R:R:T132 7.31 0 No No 8 6 2 1
R:R:P139 R:R:T138 3.5 0 No No 3 2 2 1
R:R:L142 R:R:Y146 11.72 0 No No 2 2 1 1
R:R:L148 R:R:Y374 3.52 10 No Yes 5 6 1 2
R:R:H377 R:R:L148 7.71 10 No No 7 5 1 1
R:R:I153 R:R:Y149 10.88 0 No Yes 7 5 2 1
R:R:L202 R:R:Y149 8.21 0 No Yes 7 5 2 1
R:R:A152 R:R:H381 8.78 0 No Yes 7 9 2 1
R:R:H156 R:R:H381 10.75 0 No Yes 7 9 2 1
R:R:H201 R:R:V206 4.15 0 No Yes 6 3 2 1
R:R:P207 R:R:V206 3.53 10 No Yes 3 3 1 1
R:R:L291 R:R:V212 4.47 27 Yes No 6 3 1 2
R:R:M230 R:R:Y234 13.17 0 No Yes 6 7 2 1
R:R:H302 R:R:M230 3.94 7 Yes No 6 6 1 2
R:R:M237 R:R:Y234 4.79 7 Yes Yes 9 7 2 1
R:R:V305 R:R:Y234 13.88 0 No Yes 7 7 2 1
R:R:F356 R:R:Y234 13.41 7 Yes Yes 7 7 1 1
R:R:M237 R:R:Q383 8.16 7 Yes Yes 9 9 2 2
R:R:H277 R:R:L298 3.86 0 Yes Yes 7 6 2 1
R:R:C289 R:R:L291 6.35 0 No Yes 9 6 2 1
R:R:L298 R:R:V293 2.98 7 Yes No 6 6 1 1
R:R:H296 R:R:L297 6.43 0 No Yes 2 4 1 2
R:R:H302 R:R:L298 3.86 7 Yes Yes 6 6 1 1
R:R:L309 R:R:V305 2.98 0 No No 7 7 2 2
R:R:F356 R:R:L309 3.65 7 Yes No 7 7 1 2
R:R:G353 R:R:Q355 3.29 7 No Yes 9 8 2 2
R:R:F356 R:R:G353 3.01 7 Yes No 7 9 1 2
R:R:F356 R:R:Q355 11.71 7 Yes Yes 7 8 1 2
R:R:Q355 R:R:Q383 12.8 7 Yes Yes 8 9 2 2
R:R:F356 R:R:I380 6.28 7 Yes No 7 6 1 2
R:R:F356 R:R:Q383 4.68 7 Yes Yes 7 9 1 2
R:R:M376 R:R:Y372 9.58 0 Yes Yes 7 7 1 2
R:R:I380 R:R:M376 2.92 0 No Yes 6 7 2 1
R:R:H377 R:R:H381 9.55 10 No Yes 7 9 1 1
R:R:H381 R:R:I380 3.98 0 Yes No 9 6 1 2
L:L:V32 R:R:F102 2.62 0 No Yes 0 4 0 1
R:R:V203 R:R:Y149 2.52 0 No Yes 3 5 2 1
L:L:Q10 R:R:H302 2.47 0 No Yes 0 6 0 1
R:R:N124 R:R:R126 2.41 28 No No 5 4 1 2
R:R:Y149 R:R:Y150 1.99 10 Yes No 5 4 1 2
R:R:G303 R:R:M306 1.75 0 No No 4 4 2 1
L:L:A13 R:R:V206 1.7 0 No Yes 0 3 0 1
L:L:P29 R:R:N135 1.63 0 No No 0 3 0 1
L:L:A5 R:R:M376 1.61 0 No Yes 0 7 0 1
R:R:D101 R:R:P100 1.61 0 Yes No 4 4 1 2
L:L:N22 R:R:R213 1.21 0 No No 0 2 0 1
R:R:E210 R:R:R213 1.16 0 No No 3 2 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
76.92Single9BQ3Cagrilintide9BQ3-CT (AMY2)-Cagrilintide-Gs/β1/γ2; RAMP2
76.00Single9BLBCagrilintide backbone (non-acylated)9BLB-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
76.00Single9BP3Cagrilintide9BP3-CT (AMY1)-Cagrilintide-Gs/β1/γ2; RAMP1
75.00Single9BUDCagrilintide9BUD-CT-Cagrilintide-Gs/β1/γ2
70.37Single9BTWCagrilintide9BTW-CT (AMY3)-Cagrilintide-Gs/β1/γ2; RAMP3
66.67Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
66.67Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
66.67Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
66.67Single9BUCCagrilintide9BUC-CT-Cagrilintide-Gs/β1/γ2
65.52Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
65.38Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
64.29Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
62.96Single9BLWCagrilintide backbone (non-acylated)9BLW-CT (AMY1)-Cagrilintide backbone (non-acylated)-Gs/β1/γ2; RAMP1
61.54Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
61.54Single9BLCCagrilintide backbone (non-acylated)9BLC-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
59.26Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
55.17Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
53.33Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
51.72Consensuscalcitonin_on_gpOrthosteric Ligandctlike_on_gp
51.61Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
50.00Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
50.00Single9BUECagrilintide9BUE-CT-Cagrilintide-Gs/β1/γ2
48.65Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
48.39Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
48.28Consensuscalcitonin_onOrthosteric Ligandctlike_on
46.43Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
45.95Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
45.71Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
45.45Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
45.16Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
44.83Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
44.83Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ2
44.44Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
42.42Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
42.42Single7RBTTirzepatide7RBT-GIP-Tirzepatide-LSN3556672-chim(NtGi1-Gs)/β1/γ2
41.94Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
41.94Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
41.94Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
41.94Consensusvpac_on_gpOrthosteric Ligandvpac1_on_gp vpac2_on_gp
41.18Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
40.62Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
40.62Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
40.62Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
40.62Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
40.00Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
40.00Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
40.00Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
40.00Consensuscrf_on_gpOrthosteric Ligandcrf2_on_gp crf1_on_gp
39.47Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
39.39Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
39.39Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
39.39Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
39.39Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
38.89Consensusglucagon_onOrthosteric Ligandglp_on gluc_on secretin_on gip_on
38.71Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
38.71Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
38.71Consensusvpac_onOrthosteric Ligandvpac1_on vpac2_on
37.93Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
37.93Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
37.84Consensusglucagon_on_gpOrthosteric Ligandglp_on_gp gluc_on_gp secretin_on_gp gip_on_gp
37.50Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
37.50Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
37.14Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
36.67Consensusclass-b1_class-b2_cons_onOrthosteric Ligandclass-b1_on class-b2_on
36.67Consensusclass-b1_class-b2_cons_on_gpOrthosteric Ligandclass-b1_on_gp class-b2_on_gp
36.36Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
36.36Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
36.36Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
36.36Consensusglp_onOrthosteric Ligandglp1_on glp2_on
36.36Consensusglp_on_gpOrthosteric Ligandglp1_on_gp glp2_on_gp
36.11Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
36.11Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
35.90Consensusclass-b1_onOrthosteric Ligandglucagon_on vip-pacap_on pth_on crf_on calcitonin_on
35.48Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
35.48Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
35.48Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
35.48Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
35.48Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
35.29Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
35.29Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
35.29Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
35.29Consensusvip-pacap_onOrthosteric Ligandvpac_on pac_on
35.29Consensusvip-pacap_on_gpOrthosteric Ligandvpac_on_gp pac_on_gp
35.29Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
35.29Consensusvpac2_on_gpOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
35.14Consensusclass-a_class-b1_cons_on_gpOrthosteric Ligandclass-a_on_gp class-b1_on_gp
34.48Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
34.38Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
34.38Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
34.38Consensuspac_onOrthosteric Ligandpac1_on
34.29Consensusclass-a_class-b1_cons_onOrthosteric Ligandclass-a_on class-b1_on
33.33Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
33.33Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
33.33Consensuspac_on_gpOrthosteric Ligandpac1_on_gp
32.56Consensusclass-b1_on_gpOrthosteric Ligandglucagon_on_gp vip-pacap_on_gp pth_on_gp crf_on_gp calcitonin_on_gp
32.50Consensuspth2_on_gpOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
32.43Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
32.35Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
32.35Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
32.26Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
32.14Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
32.14Single9C0KExendin-49C0K-GLP-1-Exendin-4-Gs/β1/γ2
31.58Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
31.58Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
31.58Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
31.58Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
31.58Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
31.58Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
31.43Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
31.43Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
31.43Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
31.43Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
31.43Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
31.43Single9BYOExendin-39BYO-GLP-1-Exendin-3-Gs/β1/γ2
31.43Consensusctlike_on_gpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
31.43Consensuspth1_onOrthosteric Ligand6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
31.25Single9EBOGLP-1 (ACPC18)9EBO-GLP-1-GLP-1 (ACPC18)-Gs/β1/γ2
30.95Consensuspth_on_gpOrthosteric Ligandpth1_on_gp pth2_on_gp
30.77Consensuspth_onOrthosteric Ligandpth1_on pth2_on
30.30Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
30.30Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
30.30Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
30.30Consensusvpac1_onOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
30.00Single8YWFRetatrutide8YWF-GLP-1-Retatrutide-chim(NtGi1-Gs)/β1/γ2
29.41Single6FJ3PTH6FJ3-PTH1-PTH
29.41Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
29.41Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
29.41Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
29.41Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
29.41Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
29.41Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
29.41Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
29.41Consensuspac1_onOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
29.41Consensuspac1_on_gpOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
29.41Consensusvpac1_on_gpOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
29.03Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
28.95Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
28.95Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
28.95Consensuspth1_on_gpOrthosteric Ligand6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
28.57Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
28.57Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
28.57Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
28.57Consensusglp2_on_gpOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
28.57Consensussecretin_on_gpOrthosteric Ligand7D3S-Secretin-Secretin-Gs/β1/γ2
28.12Single9B5YLong-Acting PTH9B5Y-PTH1-Long-Acting PTH-chim(NtGi1-Gq)/β1/γ2
28.12Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
27.78Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
27.59Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
27.59Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
27.27Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
27.27Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
27.03Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
27.03Consensusgip_onOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
27.03Consensusgip_on_gpOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
26.83Consensusgluc_on_gpOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
26.32Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
25.71Consensuscrf2_on_gpOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
25.71Consensussecretin_onOrthosteric Ligand7D3S-Secretin-Secretin-Gs/β1/γ2
25.00Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
25.00Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
24.39Consensusgluc_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
24.14Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
23.68Consensuscrf1_onOrthosteric Ligand6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF1-Corticoliberin-Gs/β1/γ2
23.53Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
23.08Consensusglp1_onOrthosteric Ligand7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
22.58Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
22.50Consensuscrf1_on_gpOrthosteric Ligand6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF1-Corticoliberin-Gs/β1/γ2
22.50Consensusglp1_on_gpOrthosteric Ligand7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
22.22Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
21.88Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
21.21Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
20.69Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
20.69Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
20.69Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
20.69Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
20.00Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
20.00Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
20.00Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
20.00Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
20.00Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
20.00Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
20.00Consensuslpa_offOrthosteric Ligandlpa1_off
19.44Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
19.44Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
19.44Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
19.35Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
19.35Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
19.35Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
19.23Single7VVOPTH7VVO-PTH1-PTH-Gs/β1/γ2
19.23Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
19.23Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
18.92Single4XT3Fractalkine4XT3-US28-Fractalkine
18.92Single9KFKRelaxin-39KFK-RXFP4-Relaxin-3-Gi2/β1/γ2
18.92Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
18.75Single3NY9ICI118-5513NY9-β2-ICI118-551
18.75Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
18.52Single2YDOAdenosine2YDO-A2A-Adenosine
18.52Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
18.52Single9K0KUTP9K0K-P2Y4-UTP-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Single4XT1Fractalkine4XT1-US28-Fractalkine
18.18Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
17.86Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
17.86Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
17.86Single5TGZAM65385TGZ-CB1-AM6538
17.86Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
17.86Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
17.86Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
17.86Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
17.86Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
17.86Single8T1WCVN4248T1W-GPR6-CVN424
17.86Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
17.86Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
17.86Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
17.86Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
17.86Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
17.86Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
17.86Consensushca_on_gpOrthosteric Ligandhca2_on_gp
17.65Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
17.65Single6HLOAprepitant6HLO-NK1-Aprepitant
17.65Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
17.65Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
17.65Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
17.65Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
17.65Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
17.65Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
17.50Single5GLHEndothelin-15GLH-ETB-Endothelin-1
17.50Single6IGKEndothelin-36IGK-ETB-Endothelin-3
17.39Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
17.24Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
17.24Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
17.24Single6PS6Timolol6PS6-β2-Timolol
17.24Single7SINNPS-21437SIN-CaS-NPS-2143
17.24Single7SINNPS-21437SIN-CaS-NPS-2143
17.24Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
17.24Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
17.24Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
17.24Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
17.24Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
17.24Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
17.24Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
17.24Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
17.24Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
17.24Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
17.24Single9CIBFCH-22964139CIB-HCA2-FCH-2296413
17.24Single9EE8Adenosine9EE8-A2A-Adenosine-Gs/β1/γ2
17.24Single9HC04YI9HC0-mGlu5-4YI
17.24Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
17.24Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
17.24Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
17.24Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
17.24Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.24Consensustrace-amine_onOrthosteric Ligandta1_on
17.14Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
16.67Single2YDVNECA2YDV-A2A-NECA
16.67Single4UHRCGS216804UHR-A2A-CGS21680
16.67Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
16.67Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
16.67Single5G53NECA5G53-A2A-NECA-Gs
16.67Single5V54Methiothepin5V54-5-HT1B-Methiothepin
16.67Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
16.67Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
16.67Single7P2L4YI7P2L-mGlu5-4YI
16.67Single7PX4PSB-21137PX4-A2A-PSB-2113
16.67Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
16.67Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
16.67Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
16.67Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
16.67Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
16.67Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
16.67Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
16.67Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
16.67Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
16.67Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
16.67Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
16.67Consensus5ht1_offOrthosteric Ligand5ht1b_off
16.67Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
16.67Consensusa2_onOrthosteric Liganda2b_on
16.67Consensusa2_on_gpOrthosteric Liganda2b_on_gp
16.67Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
16.67Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
16.67Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
16.67Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
16.67Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
16.67Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
16.67Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
16.67Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
16.67Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
16.67Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
16.67Consensusrelaxin_onOrthosteric Ligandrxfp4_on
16.67Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
16.67Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
16.67Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
16.22Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
16.22Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
16.22Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
16.22Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
16.22Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
16.22Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
16.13Single4N4WSANT-14N4W-SMO-SANT-1
16.13Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
16.13Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
16.13Single6OS2TRV0266OS2-AT1-TRV026
16.13Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
16.13Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
16.13Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
16.13Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
16.13Single8JWY2-1188JWY-A2A-2-118
16.13Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
16.13Single9EBIPiclidenoson9EBI-A3A-Piclidenoson-chim(NtGi1L-Gs-CtGi1)/β1/γ2
16.13Consensuslpl_offOrthosteric Ligands1p_off lpa_off
16.00Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
16.00Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
16.00Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
16.00Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
15.79Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
15.79Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
15.79Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
15.79Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
15.62Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
15.62Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
15.62Single5CGDHTL142425CGD-mGlu5-HTL14242
15.62Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
15.62Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
15.62Single7EZCUKA7EZC-A2A-UKA
15.62Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
15.62Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
15.62Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
15.62Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
15.62Single9AS02-bromo-LSD9AS0-5-HT2A-2-bromo-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
15.62Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
15.62Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
15.38Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
15.38Single6LI0C176LI0-GPR52-C17
15.38Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
15.38Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
15.38Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
15.38Single8HSCFab0468HSC-GPR20-Fab046-Gi1/β1/γ2
15.38Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
15.38Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
15.38Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
15.38Single8K5BNiacin8K5B-HCA2-Niacin
15.38Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab
15.38Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
15.38Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
15.38Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
15.38Single9B9Y7DY9B9Y-CB1-7DY
15.38Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
15.38Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
15.38Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
15.38Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
15.15Single4UG2CGS216804UG2-A2A-CGS21680
15.15Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
15.15Single5WF6UK-4320975WF6-A2A-UK-432097
15.15Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
15.15Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
15.15Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
15.15Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
15.15Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
15.15Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
15.15Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
15.15Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
15.15Single9IZASCH9002719IZA-HCA2-SCH900271-Gi1/β1/γ2
15.15Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
15.15Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
15.15Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
15.00Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
15.00Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
15.00Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
15.00Consensusbradykinin_onOrthosteric Ligandbk2_on
15.00Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
15.00Consensusendothelin_onOrthosteric Ligandetb_on eta_on
15.00Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
14.81Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
14.81Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
14.81Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
14.81Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
14.81Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
14.81Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
14.81Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
14.81Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
14.81Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
14.81Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
14.81Single9H2XA1IR19H2X-A2A-A1IR1-Na
14.81Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
14.81Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
14.81Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
14.71Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
14.71Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
14.71Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
14.71Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
14.71Single8WDTphotoNECA8WDT-A2A-photoNECA
14.71Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
14.71Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
14.71Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
14.71Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
14.71Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
14.71Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
14.63Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
14.63Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
14.63Consensusbombesin_onOrthosteric Ligandbb2_on
14.63Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
14.63Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
14.63Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
14.29Single3QAKUK-4320973QAK-A2A-UK-432097
14.29Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
14.29Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
14.29Single5IU7Q274563465IU7-A2A-Q27456346-Na
14.29Single5JTBZM-2413855JTB-A2A-ZM-241385
14.29Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
14.29Single6AQFZM-2413856AQF-A2A-ZM-241385
14.29Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
14.29Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
14.29Single6MH8ZM-2413856MH8-A2A-ZM-241385
14.29Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
14.29Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
14.29Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
14.29Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
14.29Single7T32ZM-2413857T32-A2A-ZM-241385
14.29Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
14.29Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
14.29Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
14.29Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
14.29Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
14.29Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
14.29Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
14.29Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
14.29Single8K5CAcipimox8K5C-HCA2-Acipimox
14.29Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
14.29Single8RLNLUF58348RLN-A2A-LUF5834
14.29Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
14.29Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
14.29Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
14.29Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single9BA0A1AKN9BA0-CB1-A1AKN
14.29Single9K0XATP9K0X-P2Y2-ATP-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single9K20ATP9K20-P2Y2-ATP-chim(NtGi1-Go)/β1/γ2
14.29Consensusa2_offOrthosteric Liganda2a_off
14.29Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
14.29Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
14.29Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
14.29Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
14.29Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
14.29Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
14.29Consensushca_onOrthosteric Ligandhca2_on
14.29Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
14.29Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
13.89Single5WF5UK-4320975WF5-A2A-UK-432097
13.89Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
13.89Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
13.89Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
13.89Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
13.89Consensusangiotensin_onOrthosteric Ligandat1_on
13.89Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
13.89Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
13.89Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
13.89Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
13.89Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
13.89Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
13.89Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
13.79Single3EMLZM-2413853EML-A2A-ZM-241385
13.79Single3NY8ICI118-5513NY8-β2-ICI118-551
13.79Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
13.79Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
13.79Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
13.79Single4GBRS-Carazolol4GBR-β2-S-Carazolol
13.79Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
13.79Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
13.79Single5DSGTiotropium5DSG-M4-Tiotropium
13.79Single5IU8Q274563475IU8-A2A-Q27456347-Na
13.79Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
13.79Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
13.79Single5UENDU1725UEN-A1-DU172
13.79Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
13.79Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
13.79Single6IIVDaltroban6IIV-TXA2-Daltroban
13.79Single6S0LZM-2413856S0L-A2A-ZM-241385
13.79Single6XBM5LWE6XBM-SMO-5LWE-Gi1/β1/γ2
13.79Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
13.79Single7PYRPSB-21157PYR-A2A-PSB-2115
13.79Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
13.79Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
13.79Single8CU6LJ-45178CU6-A2A-LJ-4517
13.79Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
13.79Single8JJOAlprenolol8JJO-β2-Alprenolol
13.79Single8K5DGSK2560738K5D-HCA2-GSK256073
13.79Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
13.79Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
13.79Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
13.79Single9AS1DMT9AS1-5-HT2A-DMT
13.79Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
13.79Single9CHXS-Carazolol9CHX-β2-S-Carazolol
13.79Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
13.79Single9H37A1IR09H37-A2A-A1IR0-Na
13.79Single9IZCMK19039IZC-HCA2-MK1903-Gi1/β1/γ2
13.79Single9KFJPubChem 1383196749KFJ-RXFP3-PubChem 138319674-Gi2/β1/γ2
13.79Consensusa3_onOrthosteric Liganda3a_on
13.79Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
13.79Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
13.79Consensusdopamine_offOrthosteric Ligandd2_off d3_off
13.79Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
13.79Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
13.79Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
13.79Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
13.79Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
13.51Single6JODAngiotensin II6JOD-AT2-Angiotensin II
13.51Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
13.51Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
13.51Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
13.51Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
13.51Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.51Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
13.51Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
13.51Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
13.51Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
13.51Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
13.51Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
13.51Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
13.51Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
13.51Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
13.51Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
13.51Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
13.51Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
13.51Consensusvasop-oxy_onOrthosteric Ligandv2_on
13.51Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
13.33Single2RH1S-Carazolol2RH1-β2-S-Carazolol
13.33Single2YCWS-Carazolol2YCW-β1-S-Carazolol
13.33Single4JKVTaladegib4JKV-SMO-Taladegib
13.33Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
13.33Single5CGCHTL142425CGC-mGlu5-HTL14242
13.33Single5D6LS-Carazolol5D6L-β2-S-Carazolol
13.33Single5IUAQ274563485IUA-A2A-Q27456348-Na
13.33Single5JQHS-Carazolol5JQH-β2-S-Carazolol
13.33Single5N2RPSB-365N2R-A2A-PSB-36-Na
13.33Single5N2SPSB365N2S-A1-PSB36
13.33Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
13.33Single5X7DS-Carazolol5X7D-β2-S-Carazolol-Cmpd-15
13.33Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
13.33Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
13.33Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
13.33Single6S0QZM-2413856S0Q-A2A-ZM-241385
13.33Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
13.33Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
13.33Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
13.33Single7LD3Adenosine7LD3-A1-Adenosine-MIPS521-Gi2/β1/γ2
13.33Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
13.33Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
13.33Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
13.33Single7W41PD1762527W41-BB2-PD176252
13.33Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
13.33Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
13.33Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
13.33Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.33Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
13.33Single8GNEKW-63568GNE-A2A-KW-6356-Na
13.33Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
13.33Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
13.33Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
13.33Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
13.33Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
13.33Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
13.33Single8XYKVUF106618XYK-CXCR3-VUF10661-Go/β1/γ2
13.33Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
13.33Single8ZMFA1L108ZMF-5-HT2C-A1L10
13.33Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
13.33Single8ZYTNeurotensin peptide 8-138ZYT-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
13.33Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
13.33Single9B9ZA1AKO9B9Z-CB1-A1AKO
13.33Single9DYDAsenapine9DYD-5-HT1A-Asenapine-Go/β1/γ2
13.33Single9DYFAsenapine9DYF-5-HT1A-Asenapine-Gi1/β1/γ2
13.33Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
13.33Single9EHSLUF76029EHS-A3A-LUF7602
13.33Consensusa3_on_gpOrthosteric Liganda3a_on_gp
13.33Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
13.33Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
13.33Consensusadenosine_offOrthosteric Liganda1_off a2_off
13.33Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
13.33Consensusamine_offonOrthosteric Ligandamine_off amine_on
13.33Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
13.33Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
13.33Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
13.33Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
13.33Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
13.33Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
13.33Consensusblt_offOrthosteric Ligandblt1_off
13.33Consensusbombesin_offOrthosteric Ligandbb2_off
13.33Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
13.33Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
13.33Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
13.33Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
13.33Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
13.33Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
13.16Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
13.16Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
13.16Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
13.16Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
13.16Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
13.16Single8ZRTET-18ZRT-ETB-ET-1
13.16Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
13.16Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
13.16Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
13.16Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
13.16Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
13.16Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
13.16Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
13.16Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
12.90Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
12.90Single5D5AS-Carazolol5D5A-β2-S-Carazolol
12.90Single5D5BS-Carazolol5D5B-β2-S-Carazolol
12.90Single5V56TC1145V56-SMO-TC114
12.90Single5V57TC1145V57-SMO-TC114
12.90Single6J21Aprepitant6J21-NK1-Aprepitant
12.90Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
12.90Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
12.90Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
12.90Single7F1TMIP-1a7F1T-CCR5-MIP-1a
12.90Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
12.90Single7TUYGSK682753A7TUY-GPR183-GSK682753A
12.90Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
12.90Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
12.90Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
12.90Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
12.90Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
12.90Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
12.90Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
12.90Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
12.90Single8EA0Iperoxo8EA0-M3-Iperoxo
12.90Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
12.90Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
12.90Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
12.90Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
12.90Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
12.90Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
12.90Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
12.90Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Gi1/β1/γ1
12.90Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
12.90Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
12.90Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
12.90Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
12.90Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
12.90Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
12.90Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
12.90Consensuslpa_onOrthosteric Ligandlpa1_on
12.90Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
12.90Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
12.90Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
12.82Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
12.82Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
12.82Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
12.82Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
12.82Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
12.82Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
12.82Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
12.50Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
12.50Single3D4STimolol3D4S-β2-Timolol
12.50Single4AMIBucindolol4AMI-β1-Bucindolol
12.50Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
12.50Single4XEENeurotensin4XEE-NTS1-Neurotensin
12.50Single4XESNeurotensin4XES-NTS1-Neurotensin
12.50Single5CXVTiotropium5CXV-M1-Tiotropium
12.50Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
12.50Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
12.50Single6A93Risperidone6A93-5-HT2A-Risperidone
12.50Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
12.50Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
12.50Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
12.50Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
12.50Single6IIURamatroban6IIU-TXA2-Ramatroban
12.50Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
12.50Single6YVRNTS8-136YVR-NTS1-NTS8-13
12.50Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
12.50Single7DFPSpiperone7DFP-D2-Spiperone
12.50Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
12.50Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
12.50Single7K15MKD0467K15-BLT1-MKD046-Na
12.50Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
12.50Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
12.50Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
12.50Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
12.50Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
12.50Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
12.50Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
12.50Single8HS2Fab0468HS2-GPR20-Fab046
12.50Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
12.50Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
12.50Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
12.50Single8JD3JNJ-404118138JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
12.50Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
12.50Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
12.50Single8JWZAB9288JWZ-A2A-AB928-Na
12.50Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
12.50Single8PWNTheophylline8PWN-A2A-Theophylline
12.50Single8XJNCloprosetnol8XJN-TXA2-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
12.50Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
12.50Single8XYIVUF106618XYI-CXCR3-VUF10661
12.50Single9GGGI-BOP9GGG-TXA2-I-BOP-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
12.50Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
12.50Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
12.50Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
12.50Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
12.50Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
12.50Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
12.50Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
12.50Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
12.50Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
12.50Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
12.50Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
12.50Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
12.50Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
12.20Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
12.20Single8IY6Endothelin-18IY6-ETB-Endothelin-1
12.12Single4BUONeurotensin4BUO-NTS1-Neurotensin
12.12Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
12.12Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
12.12Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
12.12Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
12.12Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
12.12Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
12.12Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
12.12Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
12.12Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
12.12Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-SBI-553-chim(NtGi1-Go)/β1/γ2
12.12Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
12.12Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
12.12Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
12.12Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
12.12Single8S2TIsoprenaline8S2T-β1-Isoprenaline-chim(NtGi1-Gs)/β1/γ2
12.12Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
12.12Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
12.12Single8XJOU466198XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
12.12Single8XVUCXCL28XVU-CXCR2-CXCL2
12.12Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
12.12Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
12.12Single9DYEBuspirone9DYE-5-HT1A-Buspirone-Go/β1/γ2
12.12Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
12.12Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
12.12Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
12.12Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
12.12Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
12.12Consensusprostanoid_offOrthosteric Ligandep_off dp_off
12.12Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
12.12Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
12.12Consensustp_onOrthosteric Ligand8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
12.12Consensustp_on_gpOrthosteric Ligand8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
12.00Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
12.00Single6XBM5LWE6XBM-SMO-5LWE-Gi1/β1/γ2
12.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
12.00Single8A2OTheophylline8A2O-A2A-Theophylline-Na
12.00Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
12.00Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
12.00Single8Y02Retinal8Y02-OPN1SW-Retinal-Gi1/β1/γ2
12.00Single9EE9Adenosine9EE9-A2A-Adenosine-Gs/β1/γ2
12.00Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
12.00Consensussensory_onOrthosteric Ligandopsins_on
11.90Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
11.76Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
11.76Single7SK9CCX6627SK9-ACKR3-CCX662
11.76Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
11.76Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
11.76Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
11.76Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
11.76Single8X5YAstemizole8X5Y-H1-Astemizole
11.76Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
11.76Single9M0RNeuropeptide VF9M0R-NPFF1-Neuropeptide VF-Gi1/β1/γ2
11.76Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
11.76Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
11.76Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
11.76Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
11.63Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
11.54Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
11.54Single3UZAGTPL92363UZA-A2A-GTPL9236
11.54Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
11.54Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
11.54Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
11.54Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
11.54Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
11.54Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
11.54Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
11.54Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
11.54Consensusgi_sensoryOrthosteric Ligandgi_opsins
11.54Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
11.54Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
11.54Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
11.54Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
11.54Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
11.43Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
11.43Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
11.43Single7F8XNN90567F8X-CCKA-NN9056
11.43Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
11.43Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
11.43Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
11.43Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
11.43Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
11.43Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
11.43Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
11.43Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
11.43Single8PKMBefiradol8PKM-5-HT1A-Befiradol-Gi1/β1/γ1
11.43Single8U4OCXCL128U4O-CXCR4-CXCL12-Gi1/β1/γ2
11.43Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
11.43Single9BUYLM1899BUY-β2-LM189-Gi1/β1/γ2
11.43Single9M4TSilodosin9M4T-Alpha1A-Silodosin
11.43Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
11.43Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
11.43Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
11.43Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
11.43Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
11.43Consensuslpl_onOrthosteric Ligands1p_on lpa_on
11.43Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
11.43Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
11.43Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
11.43Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
11.11Single3OE9IT1t3OE9-CXCR4-IT1t
11.11Single4O9RCyclopamine4O9R-SMO-Cyclopamine
11.11Single5L7IVismodegib5L7I-SMO-Vismodegib
11.11Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
11.11Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
11.11Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
11.11Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
11.11Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
11.11Single7XNACYN1548067XNA-SST2-CYN154806
11.11Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
11.11Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
11.11Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
11.11Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
11.11Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
11.11Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
11.11Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.11Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
11.11Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
11.11Single8YKDDehydroepiandrosterone8YKD-ADGRG2-Dehydroepiandrosterone-chim(NtGi1-Gs)/β1/γ2
11.11Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
11.11Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
11.11Single9E82SDF-1-beta9E82-ACKR3-SDF-1-β-Arrestin2
11.11Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
11.11Single9IQSMuscarinic toxin 39IQS-M4-Muscarinic toxin 3
11.11Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
11.11Single9IQVMuscarinic toxin 39IQV-Alpha1A-Muscarinic toxin 3
11.11Single9KFIRelaxin-39KFI-RXFP3-Relaxin-3-Gi2/β1/γ2
11.11Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
11.11Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
11.11Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
11.11Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
11.11Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
11.11Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
11.11Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
10.81Single3OE0CVX153OE0-CXCR4-CVX15
10.81Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
10.81Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.81Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
10.81Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
10.81Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
10.81Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
10.81Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
10.81Single9U4WGonadoliberin-19U4W-GnRH1-Gonadoliberin-1-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.81Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
10.81Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
10.81Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
10.81Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
10.81Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
10.81Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
10.71Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
10.71Single3PWHZM-2413853PWH-A2A-ZM-241385
10.71Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
10.71Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
10.71Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
10.71Single4BWBNeurotensin4BWB-NTS1-Neurotensin
10.71Single4QINSAG1.54QIN-SMO-SAG1.5
10.71Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
10.71Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
10.71Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
10.71Single5U09Taranabant5U09-CB1-Taranabant
10.71Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
10.71Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
10.71Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
10.71Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
10.71Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
10.71Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
10.71Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
10.71Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
10.71Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
10.71Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
10.71Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
10.71Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
10.71Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
10.71Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
10.71Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
10.71Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
10.71Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
10.71Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
10.71Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
10.71Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
10.71Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
10.71Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
10.71Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.71Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.71Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
10.71Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
10.71Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
10.71Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
10.71Single8GNGIstradefylline8GNG-A2A-Istradefylline
10.71Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
10.71Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
10.71Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
10.71Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
10.71Single8IWESpermidine8IWE-TA9-Spermidine
10.71Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
10.71Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
10.71Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
10.71Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
10.71Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
10.71Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.71Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
10.71Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
10.71Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
10.71Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
10.71Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
10.71Single8Y0HVUF114188Y0H-CXCR3-VUF11418
10.71Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go/β1/γ2
10.71Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
10.71Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ2
10.71Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
10.71Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
10.71Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
10.71Single9EBHAdenosine9EBH-A3A-Adenosine-Gi1/β1/γ2
10.71Single9EEAAdenosine9EEA-A2A-Adenosine-Gs/β1/γ2
10.71Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
10.71Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
10.71Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
10.71Consensusalpha2_offOrthosteric Ligandalpha2c_off
10.71Consensusangiotensin_offOrthosteric Ligandat1_off
10.71Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
10.71Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
10.71Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
10.71Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
10.71Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
10.71Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
10.71Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
10.71Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
10.71Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
10.71Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
10.53Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
10.53Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
10.53Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
10.53Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
10.53Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
10.53Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
10.53Single8ZBISomatostatin-148ZBI-SST3-Somatostatin-14-Gi1/β1/γ2
10.53Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
10.53Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
10.53Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
10.53Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
10.34Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
10.34Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
10.34Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
10.34Single5IUBQ274563445IUB-A2A-Q27456344-Na
10.34Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
10.34Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
10.34Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
10.34Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
10.34Single5UVIZM-2413855UVI-A2A-ZM-241385
10.34Single6FFIMMPEP6FFI-mGlu5-MMPEP
10.34Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
10.34Single6KUXRS-799486KUX-α2a-RS-79948
10.34Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
10.34Single6PS0S-Carazolol6PS0-β2-S-Carazolol
10.34Single6PS4ICI118-5516PS4-β2-ICI118-551
10.34Single6V9SGTPL114036V9S-OX1-GTPL11403
10.34Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
10.34Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
10.34Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
10.34Single6ZG9GSK10347026ZG9-M1-GSK1034702
10.34Single7AROLUF58337ARO-A2A-LUF5833-Na
10.34Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
10.34Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
10.34Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
10.34Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
10.34Single7T94Acetylcholine7T94-M2-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
10.34Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
10.34Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
10.34Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
10.34Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
10.34Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
10.34Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
10.34Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
10.34Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
10.34Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
10.34Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
10.34Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
10.34Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.34Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.34Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
10.34Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
10.34Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
10.34Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
10.34Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
10.34Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
10.34Single8IHKAcifran8IHK-HCA3-Acifran
10.34Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
10.34Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
10.34Single8K2WAMG4878K2W-CXCR3-AMG487
10.34Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
10.34Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
10.34Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
10.34Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.34Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.34Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.34Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.34Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.34Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
10.34Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
10.34Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.34Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
10.34Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
10.34Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
10.34Single9AS5Mescaline9AS5-5-HT2A-Mescaline
10.34Single9AS6Mescaline9AS6-5-HT2A-Mescaline-chim(NtGi1-Gs-CtGq)/β1/γ2
10.34Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
10.34Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
10.34Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
10.34Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
10.34Single9JFUNE52-QQ579JFU-GPR4-NE52-QQ57
10.34Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
10.34Single9M2FNeuropeptide FF9M2F-NPFF1-Neuropeptide FF-Gi1/β1/γ2
10.34Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
10.34Consensusalpha1_onOrthosteric Ligandalpha1a_on
10.34Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
10.34Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
10.34Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
10.34Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
10.34Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
10.34Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
10.34Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
10.34Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
10.34Consensusopsins_offOrthosteric Ligandrhodopsin_off
10.34Consensussensory_offOrthosteric Ligandopsins_off
10.26Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
10.26Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.26Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
10.26Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
10.26Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
10.26Single9JFYhNPSF9JFY-NPFF2-hNPSF-Gi1/β1/γ2
10.26Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
10.00Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
10.00Single2Y01Dobutamine2Y01-β1-Dobutamine
10.00Single2Y04Salbutamol2Y04-β1-Salbutamol
10.00Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
10.00Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
10.00Single4DAJTiotropium4DAJ-M3-Tiotropium
10.00Single4EJ4Naltrindole4EJ4-δ-Naltrindole
10.00Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
10.00Single4QIMANTA XV4QIM-SMO-ANTA XV
10.00Single4QKX35V4QKX-β2-35V
10.00Single4YAYZD-71554YAY-AT1-ZD-7155
10.00Single5T04Neurotensin5T04-NTS1-Neurotensin
10.00Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
10.00Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
10.00Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
10.00Single6D27CAY104716D27-DP2-CAY10471
10.00Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
10.00Single6FFHFenobam6FFH-mGlu5-Fenobam
10.00Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
10.00Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
10.00Single6GPSMK08126GPS-CCR2-MK0812
10.00Single6H7MSalbutamol6H7M-β1-Salbutamol
10.00Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
10.00Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
10.00Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
10.00Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
10.00Single6PS1Timolol6PS1-β2-Timolol
10.00Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
10.00Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.00Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
10.00Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
10.00Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
10.00Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
10.00Single7BU7BI1671077BU7-β1-BI167107
10.00Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
10.00Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
10.00Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
10.00Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
10.00Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
10.00Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
10.00Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
10.00Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
10.00Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
10.00Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
10.00Single7UL4Alvimopan7UL4-μ-Alvimopan
10.00Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
10.00Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
10.00Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
10.00Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
10.00Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
10.00Single7WC7Lisuride7WC7-5-HT2A-Lisuride
10.00Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
10.00Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
10.00Single7YXAONO-54306087YXA-S1P5-ONO-5430608
10.00Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
10.00Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
10.00Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
10.00Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
10.00Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
10.00Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
10.00Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
10.00Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.00Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.00Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.00Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.00Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.00Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.00Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.00Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.00Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.00Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.00Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
10.00Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
10.00Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
10.00Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
10.00Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
10.00Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
10.00Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
10.00Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
10.00Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
10.00Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
10.00Single8JXRLSD8JXR-D1-LSD
10.00Single8PJKST1718PJK-5-HT1A-ST171-Gi1/β1/γ1
10.00Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
10.00Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
10.00Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.00Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.00Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.00Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.00Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.00Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.00Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.00Single8X63Mepyramine8X63-H1-Mepyramine
10.00Single8X64Desloratadine8X64-H1-Desloratadine
10.00Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
10.00Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
10.00Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
10.00Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
10.00Single8YN8Proxyfan8YN8-H3-Proxyfan-Go/β1/γ2
10.00Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
10.00Single9JEAAtropine9JEA-M1-Atropine
10.00Single9PLNN-(5-methylnaphthalen-1-yl)pyridin-4-amine9PLN-α2a-N-(5-methylnaphthalen-1-yl)pyridin-4-amine
10.00Single9PLON-(5-methylnaphthalen-1-yl)pyridin-4-amine9PLO-α2a-N-(5-methylnaphthalen-1-yl)pyridin-4-amine-Go/β1/γ2
10.00Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
10.00Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
10.00Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
10.00Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
10.00Consensusalpha2_onOrthosteric Ligandalpha2b_on
10.00Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
10.00Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
10.00Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
10.00Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
10.00Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
10.00Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
10.00Consensusblt_onOrthosteric Ligandblt1_on
10.00Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
10.00Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
10.00Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
10.00Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
10.00Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
10.00Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
10.00Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
10.00Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
10.00Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
10.00Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
10.00Consensushistamine_offOrthosteric Ligandh1_off
10.00Consensusleukotriene_onOrthosteric Ligandblt_on
10.00Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
10.00Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
10.00Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
10.00Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
10.00Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
9.76Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
9.76Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
9.76Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
9.76Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
9.76Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
9.68Single2Y00Dobutamine2Y00-β1-Dobutamine
9.68Single2Y03Isoprenaline2Y03-β1-Isoprenaline
9.68Single5C1MBU725C1M-μ-BU72
9.68Single5T1ABMS-6815T1A-CCR2-BMS-681-PubChem 12093170
9.68Single5TVNLSD5TVN-5-HT2B-LSD
9.68Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
9.68Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
9.68Single6D26Fevipiprant6D26-DP2-Fevipiprant
9.68Single6GPXMK08126GPX-CCR2-MK0812
9.68Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
9.68Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
9.68Single6LUQHaloperidol6LUQ-D2-Haloperidol
9.68Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
9.68Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
9.68Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
9.68Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
9.68Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
9.68Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
9.68Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
9.68Single7C4SS1P7C4S-S1P3-S1P
9.68Single7C61Ergotamine7C61-5-HT1B-Ergotamine
9.68Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
9.68Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
9.68Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
9.68Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
9.68Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
9.68Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
9.68Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.68Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
9.68Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
9.68Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
9.68Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
9.68Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
9.68Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
9.68Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
9.68Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
9.68Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.68Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.68Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.68Single8QOTNanobody-E8QOT-μ-Nanobody-E
9.68Single8S4DCMF-0198S4D-Apelin-CMF-019
9.68Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
9.68Single8TF5Oleic acid8TF5-GPR6-Oleic acid
9.68Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
9.68Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.68Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.68Single8WGBVU01550418WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
9.68Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
9.68Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
9.68Single9ARZ2-bromo-LSD9ARZ-5-HT2A-2-bromo-LSD
9.68Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
9.68Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
9.68Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
9.68Single9F33FOB02-04A9F33-D3-FOB02-04A-Go/β1/γ2
9.68Single9F34FOB02-04A9F34-D3-FOB02-04A-Go/β1/γ2
9.68Single9K07DSO-5a9K07-BB3-DSO-5a-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.68Single9KPFSA09KPF-TAS2R16-SA0-Gi1/β1/γ2
9.68Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
9.68Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
9.68Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
9.68Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
9.68Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
9.68Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
9.68Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
9.68Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
9.68Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
9.68Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
9.68Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
9.68Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
9.68Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
9.68Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
9.68Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
9.68Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
9.68Consensusdp_offOrthosteric Liganddp2_off
9.68Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
9.68Consensusep_offOrthosteric Ligandep4_off
9.68Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
9.68Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
9.68Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
9.68Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.68Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.68Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
9.52Single6IGLIRL16206IGL-ETB-IRL1620
9.52Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
9.52Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
9.52Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
9.38Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
9.38Single4BV0Neurotensin4BV0-NTS1-Neurotensin
9.38Single4DJHJDTic4DJH-κ-JDTic
9.38Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
9.38Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
9.38Single4U15Tiotropium4U15-M3-Tiotropium
9.38Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
9.38Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
9.38Single6H7JIsoprenaline6H7J-β1-Isoprenaline
9.38Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
9.38Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
9.38Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
9.38Single6OL9Tiotropium6OL9-M5-Tiotropium
9.38Single6OS1TRV0266OS1-AT1-TRV026
9.38Single6TQ7SB-3348676TQ7-OX1-SB-334867
9.38Single6WGTLSD6WGT-5-HT2A-LSD
9.38Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
9.38Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
9.38Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
9.38Single7FEECP559407FEE-CB1-CP55940-ZCZ011
9.38Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
9.38Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
9.38Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
9.38Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
9.38Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
9.38Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
9.38Single7T9NDPPC7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
9.38Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
9.38Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
9.38Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
9.38Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.38Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
9.38Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
9.38Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
9.38Single8E0GBU728E0G-μ-BU72
9.38Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
9.38Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
9.38Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
9.38Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
9.38Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
9.38Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
9.38Single8JD5JNJ-40411813; ADX881788JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
9.38Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
9.38Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
9.38Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
9.38Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
9.38Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
9.38Single8XVLZibotentan8XVL-ETA-Zibotentan
9.38Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
9.38Single8ZW0PGD28ZW0-DP1-PGD2-Gs/β1/γ2
9.38Single9AS9RS130-1809AS9-5-HT2A-RS130-180
9.38Single9ASARS130-1809ASA-5-HT2A-RS130-180-chim(NtGi1-Gs-CtGq)/β1/γ2
9.38Single9BJKNaloxone9BJK-μ-Naloxone-NAM
9.38Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
9.38Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
9.38Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
9.38Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
9.38Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
9.38Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
9.38Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
9.38Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
9.38Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
9.38Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
9.38Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
9.38Consensusneurotensin_onOrthosteric Ligandnts1_on
9.38Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
9.38Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
9.38Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
9.38Consensustachykinin_offOrthosteric Ligandnk1_off
9.30Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
9.30Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
9.30Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
9.09Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
9.09Single4LDEBI1671074LDE-β2-BI167107
9.09Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
9.09Single5X33BIIL2605X33-BLT1-BIIL260
9.09Single6CM4Risperidone6CM4-D2-Risperidone
9.09Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
9.09Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
9.09Single6KQICP559406KQI-CB1-CP55940-Org27569
9.09Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
9.09Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
9.09Single6ZG4HTL00099366ZG4-M1-HTL0009936
9.09Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
9.09Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
9.09Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
9.09Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
9.09Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
9.09Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
9.09Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
9.09Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
9.09Single7YITNalfurafine7YIT-κ-Nalfurafine
9.09Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
9.09Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
9.09Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
9.09Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
9.09Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
9.09Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
9.09Single8JJ8Formoterol8JJ8-β2-Formoterol
9.09Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
9.09Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.09Single8XQJJN2418XQJ-Apelin-JN241
9.09Single8XWMCXCL68XWM-CXCR2-CXCL6
9.09Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
9.09Single9GL2Befiradol9GL2-5-HT1A-Befiradol-Gs/β1/γ2
9.09Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
9.09Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
9.09Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
9.09Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
9.09Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
9.09Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
9.09Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
9.09Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
9.09Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
9.09Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
9.09Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
9.09Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
9.09Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
9.09Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
9.09Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
9.09Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
9.09Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
9.09Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
9.09Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
8.82Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
8.82Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
8.82Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
8.82Single5X93K-87945X93-ETB-K-8794
8.82Single6H7LDobutamine6H7L-β1-Dobutamine
8.82Single6IBLArformoterol6IBL-β1-Arformoterol
8.82Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
8.82Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
8.82Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
8.82Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
8.82Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
8.82Single7UM4AS26747237UM4-5-HT5A-AS2674723
8.82Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.82Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
8.82Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.82Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
8.82Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
8.82Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
8.82Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
8.82Single8JPFNeurotensin8JPF-NTS1-Neurotensin-SBI-553
8.82Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
8.82Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
8.82Single8XVJMacitentan8XVJ-ETA-Macitentan
8.82Single8XWFCXCL38XWF-CXCR2-CXCL3
8.82Single9CGJC6-Quino9CGJ-δ-C6-Quino-Gi1/β1/γ2
8.82Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
8.82Single9GG5U466199GG5-TXA2-U46619-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.82Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
8.82Single9M1HProstaglandin E29M1H-EP1-Prostaglandin E2-chim(NtGi1-Gs-CtGq)/β1/γ2
8.82Single9M54Neuropeptide VF9M54-NPFF2-Neuropeptide VF-Gi1/β1/γ2
8.82Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
8.82Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
8.82Consensuscck_onOrthosteric Ligandccka_on cckb_on
8.82Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
8.82Consensuschemerin_onOrthosteric Ligandcml1_on
8.82Consensusendothelin_offOrthosteric Ligandetb_off
8.82Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
8.82Consensusfp-alpha_onOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
8.82Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
8.82Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.82Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.82Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
8.70Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
8.57Single5ZTYAM102575ZTY-CB2-AM10257
8.57Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
8.57Single6KNMJN241-96KNM-Apelin-JN241-9
8.57Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
8.57Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
8.57Single6PT3DPI-2876PT3-δ-DPI-287
8.57Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
8.57Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
8.57Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
8.57Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
8.57Single7XN9L-054,5227XN9-SST2-L-054,522
8.57Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
8.57Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
8.57Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
8.57Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
8.57Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
8.57Single8QJ2pN1628QJ2-MC4-pN162-Gs
8.57Single8XQJJN2418XQJ-Apelin-JN241
8.57Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
8.57Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
8.57Single9CGKC5-Quino9CGK-δ-C5-Quino-Gi1/β1/γ2
8.57Single9IPYJR14a9IPY-C3aB-JR14a
8.57Single9JF4PD1683689JF4-BB1-PD168368
8.57Single9MD1Buspirone9MD1-5-HT1A-Buspirone-Gz/β1/γ2
8.57Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
8.57Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
8.57Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
8.33Single4A4MAll-trans-Retinal4A4M-Rhodopsin-All-trans-Retinal-Gt(CT)
8.33Single4IARErgotamine4IAR-5-HT1B-Ergotamine
8.33Single5EN0All-trans-Retinal5EN0-Rhodopsin-All-trans-Retinal-Gt(CT)
8.33Single5MZPCaffeine5MZP-A2A-Caffeine-Na
8.33Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
8.33Single7QA8Peptide7QA8-STE2-Peptide
8.33Single7QA8Peptide7QA8-STE2-Peptide
8.33Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
8.33Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
8.33Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
8.33Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
8.33Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
8.33Single8XWNCXCL88XWN-CXCR2-CXCL8
8.33Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
8.33Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
8.33Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
8.33Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
8.33Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Consensussomatostatin_offOrthosteric Ligandsst2_off
8.11Single7SK5CXCL127SK5-ACKR3-CXCL12
8.11Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
8.11Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
8.11Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
8.11Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
8.11Single9IQRMuscarinic toxin 39IQR-α2a-Muscarinic toxin 3
8.11Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
8.11Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
8.11Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
8.00Single3PXOAll-trans-Retinal3PXO-Rhodopsin-All-trans-Retinal
8.00Single5DYSAll-trans-Retinal5DYS-Rhodopsin-All-trans-Retinal
8.00Single6VCBLSN31604406VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
8.00Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
7.89Single6PT2KGCHM076PT2-δ-KGCHM07
7.89Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
7.89Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
7.89Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
7.89Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
7.89Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
7.89Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
7.89Single9M1OMorphine-Modulating Neuropeptide B9M1O-NPFF2-Morphine-Modulating Neuropeptide B-Gi1/β1/γ2
7.89Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
7.89Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
7.89Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
7.69Single3RFMCaffeine3RFM-A2A-Caffeine
7.69Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
7.69Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
7.69Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.69Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
7.69Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Gi1/β1/γ2
7.69Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
7.69Single9IVMLSN33188399IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
7.69Consensusp2y_offOrthosteric Ligandp2y1_off
7.50Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
7.50Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
7.50Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
7.50Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
7.50Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
7.50Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
7.41Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
7.41Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
7.41Single3OE6IT1t3OE6-CXCR4-IT1t
7.41Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
7.41Single4XNWMRS25004XNW-P2Y1-MRS2500
7.41Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
7.41Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
7.41Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
7.41Single6ME5Agomelatine6ME5-MT1-Agomelatine
7.41Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
7.41Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
7.41Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
7.41Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
7.41Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
7.41Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
7.41Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
7.41Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
7.41Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
7.41Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
7.41Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
7.41Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
7.41Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
7.41Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
7.41Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
7.41Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
7.41Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
7.41Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
7.41Single9JHJC18:0 Ceramide9JHJ-FPR2-ALX-C18:0 Ceramide-Gi1/β1/γ2
7.41Single9LRCHistamine9LRC-H4-Histamine
7.41Single9LREHistamine9LRE-H4-Histamine-Gi1/β1/γ2
7.41Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
7.41Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
7.41Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
7.32Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
7.32Single7SK3CXCL127SK3-ACKR3-CXCL12
7.32Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
7.14Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
7.14Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
7.14Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
7.14Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
7.14Single3PBLEticlopride3PBL-D3-Eticlopride
7.14Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
7.14Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
7.14Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
7.14Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
7.14Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
7.14Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
7.14Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
7.14Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
7.14Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
7.14Single7V68Iperoxo7V68-M4-Iperoxo-LY2119620-Gi1/β1/γ2
7.14Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
7.14Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
7.14Single7XP6Strychnine7XP6-TAS2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
7.14Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
7.14Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
7.14Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.14Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
7.14Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
7.14Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
7.14Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
7.14Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
7.14Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
7.14Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
7.14Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
7.14Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
7.14Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
7.14Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
7.14Single8YN7Immethridine8YN7-H3-Immethridine-Go/β1/γ2
7.14Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
7.14Single9AS2DMT9AS2-5-HT2A-DMT-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14Single9E7RGB889E7R-PAR2-GB88-chim(NtGi1L-Gs-CtGq)/β1/γ2
7.14Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
7.14Single9KDFRES-701-39KDF-ETB-RES-701-3
7.14Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
7.14Single9LMPNE52-QQ579LMP-GPR4-NE52-QQ57
7.14Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg4_on
7.14Consensusadgrg_on_gpOrthosteric Ligandadgrg2_on_gp adgrg4_on_gp
7.14Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
7.14Consensusgq_nucleotideOrthosteric Ligandgq_p2y
7.14Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
6.98Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
6.98Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
6.90Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
6.90Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
6.90Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
6.90Single3ODUIT1t3ODU-CXCR4-IT1t
6.90Single4K5YCP-3763954K5Y-CRF1-CP-376395
6.90Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
6.90Single4S0VSuvorexant4S0V-OX2-Suvorexant
6.90Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
6.90Single5WS3EMPA5WS3-OX2-EMPA
6.90Single5ZKQABT-4915ZKQ-PAF-ABT-491
6.90Single6B73MP11046B73-κ-MP1104
6.90Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
6.90Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
6.90Single6ME2Ramelteon6ME2-MT1-Ramelteon
6.90Single6ME9Ramelteon6ME9-MT2-Ramelteon
6.90Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
6.90Single6TODEMPA6TOD-OX1-EMPA-Na
6.90Single6TPJSuvorexant6TPJ-OX2-Suvorexant
6.90Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
6.90Single7BR3Elagolix7BR3-GnRH1-Elagolix
6.90Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
6.90Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
6.90Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
6.90Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
6.90Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
6.90Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
6.90Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
6.90Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
6.90Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
6.90Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.90Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
6.90Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
6.90Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
6.90Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
6.90Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
6.90Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
6.90Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
6.90Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
6.90Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
6.90Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
6.90Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
6.90Single9K6LSA09K6L-TAS2R16-SA0-Gi2/β1/γ2
6.90Single9KPESA09KPE-TAS2R16-SA0-Gi1/β1/γ2
6.90Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
6.90Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
6.90Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
6.90Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
6.90Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
6.90Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
6.90Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
6.90Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
6.90Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
6.90Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
6.90Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
6.82Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
6.67Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
6.67Single3REYXAC3REY-A2A-XAC
6.67Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
6.67Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
6.67Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
6.67Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
6.67Single4ZJCSB-6740424ZJC-OX1-SB-674042
6.67Single6A94Zotepine6A94-5-HT2A-Zotepine
6.67Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
6.67Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
6.67Single6PS5S-Propranolol6PS5-β2-S-Propranolol
6.67Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
6.67Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
6.67Single6TP3Nemorexant6TP3-OX1-Nemorexant
6.67Single6TPGEMPA6TPG-OX2-EMPA
6.67Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
6.67Single6VI4JDTic6VI4-κ-JDTic
6.67Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
6.67Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
6.67Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
6.67Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
6.67Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
6.67Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
6.67Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
6.67Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
6.67Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
6.67Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
6.67Single7F61PF-036547467F61-H3-PF-03654746
6.67Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
6.67Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.67Single7T94LY21196207T94-M2-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
6.67Single7UL3Famotidine7UL3-H2-Famotidine
6.67Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
6.67Single7UTZDPPC7UTZ-TSH-TR1402-DPPC-Gs/β1/γ2
6.67Single7VV6C48/807VV6-MRGPRX2-C48/80
6.67Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
6.67Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
6.67Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
6.67Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.67Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
6.67Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
6.67Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
6.67Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
6.67Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
6.67Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
6.67Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
6.67Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
6.67Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
6.67Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
6.67Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
6.67Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
6.67Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
6.67Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
6.67Single8Y6YGLPG09748Y6Y-FFA2-GLPG0974
6.67Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
6.67Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
6.67Single8ZPMAMD0708ZPM-CXCR4-AMD070
6.67Single8ZPNAMD31008ZPN-CXCR4-AMD3100
6.67Single9AS3LSD9AS3-5-HT2A-LSD
6.67Single9AS4LSD9AS4-5-HT2A-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
6.67Single9JH3CMF-0199JH3-Apelin-CMF-019-Gi1/β1/γ2
6.67Single9JMDAzithromycin9JMD-Motilin-Azithromycin-chim(Gs-CtGq)/β1/γ2
6.67Single9KPDSA09KPD-TAS2R16-SA0-chim(Gs-CtGt3)/β1/γ2
6.67Single9LRDHistamine9LRD-H1-Histamine-Gi1/β1/γ2
6.67Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
6.67Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
6.67Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
6.67Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
6.67Consensusgrh_offOrthosteric Ligandgnrh1_off
6.67Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
6.67Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
6.52Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
6.45Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
6.45Single2Y02Carmoterol2Y02-β1-Carmoterol
6.45Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
6.45Single4MQSIperoxo4MQS-M2-Iperoxo
6.45Single4U14Tiotropium4U14-M3-Tiotropium
6.45Single4Z9GCP-3763954Z9G-CRF1-CP-376395
6.45Single5DHHSB-6121115DHH-NOP-SB-612111
6.45Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
6.45Single5UIGCmpd-15UIG-A2A-Cmpd-1
6.45Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
6.45Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/β1/γ2
6.45Single6TOTLemborexant6TOT-OX1-Lemborexant
6.45Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
6.45Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
6.45Single7F83PF-051904577F83-Ghrelin-PF-05190457
6.45Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
6.45Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
6.45Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
6.45Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
6.45Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
6.45Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
6.45Single7V3ZCP559407V3Z-CB1-CP55940
6.45Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
6.45Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
6.45Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
6.45Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
6.45Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
6.45Single8GTIBMK-C2058GTI-CRF1-BMK-C205
6.45Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
6.45Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
6.45Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
6.45Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
6.45Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
6.45Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
6.45Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
6.45Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
6.45Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
6.45Single8ZYYNeurotensin peptide 8-138ZYY-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
6.45Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
6.45Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
6.45Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
6.45Single9IYAONO-97105319IYA-GPR55-ONO-9710531
6.45Single9JGKBalovaptan9JGK-5-HT2B-Balovaptan
6.45Single9PQD(6m)-1-methyl-6-(1,2,5,6-tetrahydropyridin-3-yl)-1h-indole9PQD-α2a-(6m)-1-methyl-6-(1,2,5,6-tetrahydropyridin-3-yl)-1h-indole
6.45Consensus5ht5_onOrthosteric Ligand5ht5a_on
6.45Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
6.45Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
6.45Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
6.45Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
6.45Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
6.45Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
6.45Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
6.25Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
6.25Single5WIUNemonapride5WIU-D4-Nemonapride
6.25Single5WIVNemonapride5WIV-D4-Nemonapride-Na
6.25Single5WQCEMPA5WQC-OX2-EMPA
6.25Single5XPRBosentan5XPR-ETB-Bosentan
6.25Single6E67BI1671076E67-β2-BI167107-Gs(CT)
6.25Single6HLPNetupitant6HLP-NK1-Netupitant
6.25Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
6.25Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
6.25Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
6.25Single6TP6Filorexant6TP6-OX1-Filorexant
6.25Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
6.25Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
6.25Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
6.25Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
6.25Single7WC6LSD7WC6-5-HT2A-LSD
6.25Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
6.25Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.25Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
6.25Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
6.25Single8GTGBMK-I1528GTG-CRF1-BMK-I152
6.25Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
6.25Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
6.25Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
6.25Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
6.25Single8ZVZBW245C8ZVZ-DP1-BW245C-Gs/β1/γ2
6.25Single9ARYSerotonin9ARY-5-HT2A-Serotonin-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25Single9GE2ML1849GE2-GPR55-ML184-chim(NtGi1-G13)/β1/γ2
6.25Single9HAPTolvaptan9HAP-V2-Tolvaptan
6.25Single9I52A1IZU9I52-D1-A1IZU-Gs/β1/γ2
6.25Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
6.25Consensusadgrg2_onOrthosteric Ligand7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
6.25Consensusadgrg2_on_gpOrthosteric Ligand7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
6.25Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
6.25Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
6.25Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
6.25Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
6.25Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
6.06Single3P0GBI1671073P0G-β2-BI167107
6.06Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
6.06Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
6.06Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
6.06Single5XR8AM8415XR8-CB1-AM841
6.06Single5XRAAM115425XRA-CB1-AM11542
6.06Single6J20Aprepitant6J20-NK1-Aprepitant
6.06Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
6.06Single7B6WCyclazosin7B6W-α1b-Cyclazosin
6.06Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
6.06Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
6.06Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
6.06Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
6.06Single7R0CAVP7R0C-V2-AVP-Arrestin2
6.06Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
6.06Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
6.06Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.06Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
6.06Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.06Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
6.06Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
6.06Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
6.06Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
6.06Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
6.06Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
6.06Single8JD5JNJ-40411813; ADX881788JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
6.06Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
6.06Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
6.06Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
6.06Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
6.06Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
6.06Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
6.06Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
6.06Single8ZWFJR14a8ZWF-C3aB-JR14a
6.06Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
6.06Single9EGOYVF9EGO-CB1-YVF-Gi1/β1/γ2
6.06Single9I54A1IZV9I54-D1-A1IZV-Gs/β1/γ2
6.06Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
6.06Single9IK9SST analogue9IK9-SST1-SST analogue-Gi1/β1/γ2
6.06Single9JMCDS-3801b9JMC-Motilin-DS-3801b-chim(Gs-CtGq)/β1/γ2
6.06Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
6.06Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
6.06Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
5.88Single4RWADIPP-NH24RWA-δ-DIPP-NH2
5.88Single6MXTSalmeterol6MXT-β2-Salmeterol
5.88Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
5.88Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
5.88Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.88Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
5.88Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
5.88Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.88Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
5.88Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
5.88Single8GTMBMK-C2038GTM-CRF1-BMK-C203
5.88Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88Single8JJLOlodaterol8JJL-β2-Olodaterol
5.88Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
5.88Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
5.88Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
5.88Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
5.88Single8XWACXCL18XWA-CXCR2-CXCL1
5.88Single8XWSCXCL58XWS-CXCR2-CXCL5
5.88Single9AU0BW245C9AU0-DP1-BW245C-Gs/β1/γ2
5.88Single9BJKNAM9BJK-μ-Naloxone-NAM
5.88Single9DGIZ85267113509DGI-CB1-Z8526711350
5.88Single9M4QDoxazosin9M4Q-Alpha1A-Doxazosin
5.88Consensusalpha1_offOrthosteric Ligandalpha1a_off
5.88Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
5.88Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
5.88Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
5.88Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
5.88Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
5.88Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
5.88Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
5.88Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
5.88Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
5.88Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
5.88Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.88Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.71Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
5.71Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
5.71Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
5.71Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
5.71Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
5.71Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
5.71Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
5.71Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
5.71Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
5.71Single8T3OTUG-8918T3O-FFA4-TUG-891-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.71Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
5.71Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
5.71Single8ZPLHF511168ZPL-CXCR4-HF51116
5.71Single8ZWGJR14a8ZWG-C3aB-JR14a-Gi1/β1/γ2
5.71Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
5.71Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
5.71Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
5.71Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
5.71Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
5.71Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
5.71Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
5.56Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
5.56Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
5.56Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
5.56Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
5.56Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
5.56Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
5.56Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
5.56Single8Y72Peptide8Y72-μ-Peptide-BMS-986122-Gi1/β1/γ2
5.56Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
5.56Single9IPVJR14a9IPV-C3aB-JR14a-Gi1/β1/γ2
5.56Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56Single9JH6C20:0 Ceramide9JH6-CysLT2-C20:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56Single9V2NMacimorelin9V2N-Ghrelin-Macimorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
5.56Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
5.41Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
5.41Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
5.41Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
5.41Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
5.41Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
5.41Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
5.41Single8IEBA1LYA8IEB-GPR156-A1LYA
5.41Single8IEIA1LYA8IEI-GPR156-A1LYA
5.41Single8IEIA1LYA8IEI-GPR156-A1LYA
5.41Single8IEPA1LYA8IEP-GPR156-A1LYA
5.41Single8IEPA1LYA8IEP-GPR156-A1LYA
5.41Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
5.41Single8ZBJSomatostatin-148ZBJ-SST5-Somatostatin-14-Gi1/β1/γ2
5.41Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
5.41Single9HB3Mambaquaretin-19HB3-V2-Mambaquaretin-1
5.41Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
5.26Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
5.26Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
5.26Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
5.26Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
5.26Single8IEBA1LYA8IEB-GPR156-A1LYA
5.26Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
5.26Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
5.26Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
5.26Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
5.26Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
5.13Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
5.13Single8W8YGamma-MSH8W8Y-MC3-γ-MSH-Ca-Gs/β1/γ2
5.13Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
5.13Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
5.00Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
5.00Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
5.00Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
5.00Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
5.00Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
5.00Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
4.88Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
4.88Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
4.88Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
4.76Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
4.76Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
4.65Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
4.65Single8W8XBeta-MSH8W8X-MC3-β-MSH-Ca-Gs/β1/γ2
4.65Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
4.55Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
4.55Single6D35Cholesterol6D35-SMO-Cholesterol
4.55Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
4.55Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
4.55Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
4.55Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
4.55Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042
4.55Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042
4.55Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042
4.55Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-BHFF
4.55Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
4.55Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626
4.55Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
4.55Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
4.55Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
4.55Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
4.55Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
4.55Single7DTTCa7DTT-CaS-Ca-Ca
4.55Single7DTTCa7DTT-CaS-Ca-Ca
4.55Single7DTUTryptophan7DTU-CaS-Tryptophan
4.55Single7DTUTryptophan7DTU-CaS-Tryptophan
4.55Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
4.55Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
4.55Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
4.55Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
4.55Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.55Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.55Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.55Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.55Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
4.55Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
4.55Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
4.55Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
4.55Single7EB2Baclofen7EB2-GABAB2; GABAB1-Baclofen-rac-BHFF-Gi1/β1/γ2
4.55Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
4.55Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
4.55Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
4.55Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
4.55Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
4.55Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
4.55Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
4.55Single7FIIhCG7FII-LH-hCG-chim(NtGi1-Gs)/β1/γ2
4.55Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
4.55Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
4.55Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
4.55Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
4.55Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.55Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.55Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.55Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.55Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
4.55Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
4.55Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
4.55Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
4.55Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
4.55Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
4.55Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
4.55Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
4.55Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
4.55Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
4.55Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.55Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.55Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.55Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.55Single7T9NM22 Fab7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
4.55Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
4.55Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
4.55Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
4.55Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
4.55Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
4.55Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
4.55Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
4.55Single7XW7K1-707XW7-TSH-K1-70
4.55Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
4.55Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
4.55Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
4.55Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
4.55Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
4.55Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
4.55Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
4.55Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
4.55Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
4.55Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
4.55Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
4.55Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
4.55Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-NAM563
4.55Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
4.55Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
4.55Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
4.55Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
4.55Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
4.55Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
4.55Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
4.55Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
4.55Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
4.55Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
4.55Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
4.55Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
4.55Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
4.55Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
4.55Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
4.55Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
4.55Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
4.55Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
4.55Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
4.55Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
4.55Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
4.55Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
4.55Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
4.55Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
4.55Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
4.55Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
4.55Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
4.55Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
4.55Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
4.55Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
4.55Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
4.55Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
4.55Single8WG9(2S)-2-amino-4-phosphonobutanoic acid8WG9-mGlu4; mGlu2-(2S)-2-amino-4-phosphonobutanoic acid
4.55Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
4.55Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
4.55Single8WGCLY3792688WGC-mGlu4; mGlu2-LY379268
4.55Single8WGDWAG; WA68WGD-mGlu4; mGlu2-WAG; WA6
4.55Single8WGDWAG; WA68WGD-mGlu4; mGlu2-WAG; WA6
4.55Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
4.55Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
4.55Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.55Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.55Single8WVXNorrin8WVX-LGR4-Norrin
4.55Single8WVYNorrin8WVY-LGR4-Norrin
4.55Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
4.55Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
4.55Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
4.55Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
4.55Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
4.55Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
4.55Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
4.55Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
4.55Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
4.55Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
4.55Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
4.55Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
4.55Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
4.55Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
4.55Single8XUMR-spondin-28XUM-LGR4-R-spondin-2
4.55Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
4.55Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
4.55Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
4.55Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
4.55Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
4.55Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
4.55Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
4.55Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
4.55Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
4.55Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
4.55Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
4.55Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
4.55Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
4.55Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
4.55Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
4.55Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
4.55Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
4.55Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
4.55Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
4.55Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
4.55Single9KHHNorrin9KHH-LGR4-Norrin
4.55Single9S37NB219S37-LGR4-NB21
4.55Single9UTBSucralose9UTB-TAS1R2; TAS1R3-Sucralose
4.44Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
4.35Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.35Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.35Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.35Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.35Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.35Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.35Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.35Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.35Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
4.35Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
4.35Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
4.35Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
4.35Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
4.35Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
4.35Consensusclass-b2_onOrthosteric Ligandadgrg_on adgrf_on adgrl_on adgre_on adgrd_on
4.35Consensusclass-b2_on_gpOrthosteric Ligandadgrg_on_gp adgrf_on_gp adgrl_on_gp adgre_on_gp adgrd_on_gp
4.17Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
4.17Single7T9MCS-17 Antibody7T9M-TSH-CS-17 Antibody
4.17Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
4.00Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
4.00Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/β1/γ2
4.00Single7UTZTR14027UTZ-TSH-TR1402-DPPC-Gs/β1/γ2
4.00Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/β1/γ2
4.00Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
4.00Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
3.85Single5L7DCholesterol5L7D-SMO-Cholesterol
3.85Single7T9ITSH7T9I-TSH-TSH-Gs/β1/γ2
3.85Single7V68LY21196207V68-M4-Iperoxo-LY2119620-Gi1/β1/γ2
3.85Single8I2GGlycoprotein hormones alpha chain8I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
3.85Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
3.70Single3OE8IT1t3OE8-CXCR4-IT1t
3.70Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
3.70Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
3.70Single9CHUNoradrenaline9CHU-β2-Noradrenaline
3.57Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
3.57Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
3.57Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.57Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
3.57Single8JPSCCL78JPS-ACKR1-CCL7
3.57Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
3.57Consensus5ht2_onOrthosteric Ligand5ht2b_on
3.57Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.57Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
3.45Single6HLLCP999946HLL-NK1-CP99994
3.45Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
3.45Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
3.45Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
3.45Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.45Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
3.45Single7SRQLSD7SRQ-5-HT2B-LSD
3.45Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
3.45Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
3.45Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
3.45Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
3.45Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
3.45Single8ZYUNeurotensin peptide 8-138ZYU-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
3.45Single9AS7Psilocin9AS7-5-HT2A-Psilocin
3.45Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
3.45Single9IXJHistamine9IXJ-H2-Histamine-Gs/β1/γ2
3.45Single9IZDCHBA9IZD-HCA1-CHBA-Gi1/β1/γ2
3.45Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
3.45Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
3.45Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
3.33Single6AKXA4R6AKX-CCR5-A4R
3.33Single6AKYMaraviroc6AKY-CCR5-Maraviroc
3.33Single6C1QNDT95137276C1Q-C5a1-PMX53-NDT9513727
3.33Single6DS0Ly2660976DS0-5-HT2B-Ly266097
3.33Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
3.33Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
3.33Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
3.33Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
3.33Single7F8ULintitript7F8U-CCKA-Lintitript
3.33Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
3.33Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.33Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
3.33Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
3.33Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
3.33Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
3.33Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
3.33Single7XRRLemborexant7XRR-OX2-Lemborexant
3.33Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.33Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
3.33Single8U4PAMD31008U4P-CXCR4-AMD3100-Gi1/β1/γ2
3.33Single9LRBHistamine9LRB-H1-Histamine-Gs/β1/γ2
3.33Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
3.33Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.33Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
3.33Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
3.33Consensusorexin_offOrthosteric Ligandox2_off ox1_off
3.33Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
3.23Single3RZECidoxepin3RZE-H1-Cidoxepin
3.23Single4MBSMaraviroc4MBS-CCR5-Maraviroc
3.23Single6IQLL7458706IQL-D4-L745870
3.23Single6TPKRetosiban6TPK-OT-Retosiban
3.23Single6TPNHTL66416TPN-OX2-HTL6641
3.23Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
3.23Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
3.23Single7VODCariprazine7VOD-5-HT2A-Cariprazine
3.23Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
3.23Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
3.23Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
3.23Single8JD6VU03647708JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
3.23Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
3.23Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
3.23Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
3.23Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
3.23Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
3.23Single9ARXSerotonin9ARX-5-HT2A-Serotonin
3.23Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
3.23Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
3.23Consensusvasop-oxy_offOrthosteric Ligandot_off
3.12Single5DHGC-355DHG-NOP-C-35
3.12Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
3.12Single6DRXLisuride6DRX-5-HT2B-Lisuride
3.12Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
3.12Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
3.12Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
3.12Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
3.12Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
3.12Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
3.12Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
3.12Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
3.12Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
3.12Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
3.12Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
3.12Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
3.12Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
3.03Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
3.03Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
3.03Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
3.03Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
3.03Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
3.03Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
3.03Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
3.03Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
3.03Single8JXSPF-61428JXS-D1-PF-6142
3.03Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
3.03Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
3.03Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
3.03Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
2.94Single5TZRMK86665TZR-FFA1-MK8666
2.94Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
2.94Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
2.94Single6E59L-7607356E59-NK1-L-760735
2.94Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
2.94Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
2.94Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
2.94Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
2.94Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
2.94Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
2.94Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
2.94Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
2.94Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
2.94Single8Y73Peptide8Y73-μ-Peptide-MPAM-15-Gi1/β1/γ2
2.94Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
2.94Single9UY3Anamorelin9UY3-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
2.94Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
2.94Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
2.94Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
2.94Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
2.94Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
2.94Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
2.86Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
2.86Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
2.86Single4PY02MeSATP4PY0-P2Y12-2MeSATP
2.86Single5TZYMK8666; AP85TZY-FFA1-MK8666; AP8
2.86Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
2.86Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
2.86Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
2.86Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
2.86Single8Y6WTUG-13758Y6W-FFA2-TUG-1375-4-CMTB-Gi1/β1/γ2
2.86Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
2.86Consensusorexin_onOrthosteric Ligandox2_on
2.78Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
2.78Single6K1QIRL25006K1Q-ETB-IRL2500
2.78Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
2.78Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
2.78Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
2.78Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
2.78Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
2.70Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
2.70Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
2.70Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
2.70Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
2.70Consensuskisspeptin_onOrthosteric Ligandkiss1_on
2.63Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
2.63Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
2.63Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
2.63Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
2.63Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
2.63Single8KIGSHU91198KIG-MC3-SHU9119-Ca
2.63Single8WKYPG-9348WKY-MC4-PG-934
2.63Single8XFTR-spondin-28XFT-LGR4-R-spondin-2-ZNRF3
2.63Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-ZNRF3
2.63Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
2.63Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
2.63Single9J0IUDP-Glucuronic acid9J0I-P2Y14-UDP-Glucuronic acid-Gi1/β1/γ2
2.63Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
2.63Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
2.63Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
2.63Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
2.63Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
2.56Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
2.56Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
2.56Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
2.56Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
2.56Single9IK8SST analogue9IK8-SST1-SST analogue-Gi1/β1/γ2
2.56Single9J0FNADH9J0F-P2Y14-NADH-Gi1/β1/γ2
2.56Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
2.50Single6W25SHU91196W25-MC4-SHU9119-Ca
2.50Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
2.50Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
2.50Single8WVUR-spondin-18WVU-LGR4-R-spondin-1-RNF43
2.50Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-ZNRF3
2.50Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
2.50Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
2.50Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
2.50Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
2.44Single8XFPR-spondin-28XFP-LGR4-R-spondin-2-ZNRF3
2.44Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
2.38Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
2.27Single8W8WAlpha-MSH8W8W-MC3-α-MSH-Ca-Gs/β1/γ2
2.27Single8XFSR-spondin-28XFS-LGR4-R-spondin-2-ZNRF3

PDB Summary
PDB 9BUB
Class B1
SubFamily Peptide
Type Calcitonin
SubType CT
Species Homo Sapiens
Ligand Cagrilintide
Other Ligand(s) -
Protein Partners Gs/Beta1/Gamma2
PDB Resolution 2.3
Date 2025-04-23
D.O.I. doi.org/10.1038/s41467-025-58680-y
Net Summary
Imin 2.92
Number of Linked Nodes 983
Number of Links 1217
Number of Hubs 202
Number of Links mediated by Hubs 733
Number of Communities 33
Number of Nodes involved in Communities 298
Number of Links involved in Communities 433
Path Summary
Number Of Nodes in MetaPath 135
Number Of Links MetaPath 134
Number of Shortest Paths 1752523
Length Of Smallest Path 3
Average Path Length 33.9328
Length of Longest Path 73
Minimum Path Strength 1.185
Average Path Strength 6.87027
Maximum Path Strength 37.295
Minimum Path Correlation 0.72
Average Path Correlation 0.989893
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.32558
Average % Of Corr. Nodes 55.0862
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 45.0522
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain   • G protein-coupled receptor-like
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain   • G protein-coupled receptor-like
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeGGL
PDB ResiduesL:L:?0
Environment DetailsOpen EMBL-EBI Page
CodeGGL
NameGlutamic acid
SynonymsGlutamic acid
Identifier
FormulaC5 H9 N O4
Molecular Weight147.129
SMILES
PubChem44272391
Formal Charge0
Total Atoms19
Total Chiral Atoms1
Total Bonds18
Total Aromatic Bonds0

CodeNH2
PDB ResiduesL:L:?38
Environment DetailsOpen EMBL-EBI Page
CodeNH2
NameAMINO GROUP
Synonyms
Identifier
FormulaH2 N
Molecular Weight16.023
SMILES
PubChem123329
Formal Charge0
Total Atoms3
Total Chiral Atoms0
Total Bonds2
Total Aromatic Bonds0

Code_L_
PDB ResiduesL:L:?101
Environment DetailsOpen EMBL-EBI Page
Code_L_
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds

PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>9BUB_Chain_A
DQRNEEKAQ REANKKIEK QLQKDKQVY RATHRLLLL GAGESGKTI 
VKQMTSGIF ETKFQVDKV NFHMFDVGQ RDERRKWIQ CFNDVTAII 
FVVASNRLQ ALLFSIWNN WLRSVILFL NKQDLLAEK VLAGKSKIE 
DYFPEFARY TTPEDATPE PGEDPRVTR AKYFIRDEF LRISTASGD 
GRHYCYPHF TCVDTENIR RVFNDCRDI IQRMHLRQY ELLNAAKDK 
DTS


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>9BUB_Chain_B
SELDQLRQE AEQLKNQIR DARKACADA TLSQITNNI DPVGRIQMR 
TRRTLRGHL AKIYAMHWG TDSRLLVSA SQDGKLIIW DSYTTNKVH 
AIPLRSSWV MTCAYAPSG NYVACGGLD NICSIYNLK TREGNVRVS 
RELAGHTGY LSCCRFLDD NQIVTSSGD TTCALWDIE TGQQTTTFT 
GHTGDVMSL SLAPDTRLF VSGACDASA KLWDVREGM CRQTFTGHE 
SDINAICFF PNGNAFATG SDDATCRLF DLRADQELM TYSHDNIIC 
GITSVSFSK SGRLLLAGY DDFNCNVWD ALKADRAGV LAGHDNRVS 
CLGVTDDGM AVATGSWDS FLKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>9BUB_Chain_G
SIAQARKLV EQLKMEANI DRIKVSKAA ADLMAYCEA HAKEDPLLT 
PVPASENPF R


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP30988
Sequence
>9BUB_Chain_R
YVVGRKKMM DAQYKCYDR MQQLPAYQG EGPYCNRTW DGWLCWDDT 
PAGVLSYQF CPDYFPDFD PSEKVTKYC DEKGVWFKH PENNRTWSN 
YTMCNAFTP EKLKNAYVL YYLAIVGHS LSIFTLVIS LGIFVFFRS 
LGCQRVTLH KNMFLTYIL NSMIIIIHL VEVVPNGEL VRRDPVSCK 
ILHFFHQYM MACNYFWML CEGIYLHTL IVVAVFTEK QRLRWYYLL 
GWGFPLVPT TIHAITRAV YFNDNCWLS VETHLLYII HGPVMAALV 
VNFFFLLNI VRVLVTKMR ETHEAESHM YLKAVKATM ILVPLLGIQ 
FVVFPWRPS NKMLGKIYD YVMHSLIHF QGFFVATIY CFCNNEVQT 
TVKRQWAQ


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7X5HAAmine5-Hydroxytryptamine5-HT5AHomo sapiens5-CT-Gi1/β1/γ23.12022-09-14doi.org/10.1038/s41421-022-00412-3
7X5H (No Gprot) AAmine5-Hydroxytryptamine5-HT5AHomo sapiens5-CT-3.12022-09-14doi.org/10.1038/s41421-022-00412-3
7UM5AAmine5-Hydroxytryptamine5-HT5AHomo sapiens5-CT-chim(NtGi1-Go)/β1/γ22.732022-07-20doi.org/10.1038/s41594-022-00796-6
7UM5 (No Gprot) AAmine5-Hydroxytryptamine5-HT5AHomo sapiens5-CT-2.732022-07-20doi.org/10.1038/s41594-022-00796-6
7XTCAAmine5-Hydroxytryptamine5-HT7Homo sapiens5-CT-Gs/β1/γ23.22022-07-27doi.org/10.1016/j.molcel.2022.05.031
7XTC (No Gprot) AAmine5-Hydroxytryptamine5-HT7Homo sapiens5-CT-3.22022-07-27doi.org/10.1016/j.molcel.2022.05.031
6E67AAmineAdrenergicβ2Homo sapiensBI167107-Gs(CT)3.72019-06-05doi.org/10.1016/j.cell.2019.04.021
6NIYB1PeptideCalcitoninCTHomo sapiensAdrenomedullin-Gs/β1/γ23.342019-01-23doi.org/10.1021/acsptsci.8b00056
6NIY (No Gprot) B1PeptideCalcitoninCTHomo sapiensAdrenomedullin-3.342019-01-23doi.org/10.1021/acsptsci.8b00056
5UZ7B1PeptideCalcitoninCTHomo sapiens--Gs/β1/γ24.12017-05-03doi.org/10.1038/nature22327
5UZ7 (No Gprot) B1PeptideCalcitoninCTHomo sapiens--4.12017-05-03doi.org/10.1038/nature22327
8F0JB1PeptideCalcitoninCTHomo sapiensPramlintide Analogue San45-Gs/β1/γ222023-08-02doi.org/10.1038/s41589-023-01393-4
8F0J (No Gprot) B1PeptideCalcitoninCTHomo sapiensPramlintide Analogue San45-22023-08-02doi.org/10.1038/s41589-023-01393-4
7TYLB1PeptideCalcitoninCTHomo sapiensAmylin-Gs/β1/γ23.32022-03-23doi.org/10.1126/science.abm9609
7TYL (No Gprot) B1PeptideCalcitoninCTHomo sapiensAmylin-3.32022-03-23doi.org/10.1126/science.abm9609
7TYOB1PeptideCalcitoninCTHomo sapiensCalcitonin-Gs/β1/γ22.72022-03-23doi.org/10.1126/science.abm9609
7TYO (No Gprot) B1PeptideCalcitoninCTHomo sapiensCalcitonin-2.72022-03-23doi.org/10.1126/science.abm9609
7TYIB1PeptideCalcitoninCTHomo sapiensAmylin-Gs/β1/γ23.32022-03-30doi.org/10.1126/science.abm9609
7TYI (No Gprot) B1PeptideCalcitoninCTHomo sapiensAmylin-3.32022-03-30doi.org/10.1126/science.abm9609
7TYNB1PeptideCalcitoninCTHomo sapiensCalcitonin-1-Gs/β1/γ22.62022-03-30doi.org/10.1126/science.abm9609
7TYN (No Gprot) B1PeptideCalcitoninCTHomo sapiensCalcitonin-1-2.62022-03-30doi.org/10.1126/science.abm9609
9BUBB1PeptideCalcitoninCTHomo sapiensCagrilintide-Gs/β1/γ22.32025-04-23doi.org/10.1038/s41467-025-58680-y
9BUB (No Gprot) B1PeptideCalcitoninCTHomo sapiensCagrilintide-2.32025-04-23doi.org/10.1038/s41467-025-58680-y
9BLBB1PeptideCalcitoninCTHomo sapiensCagrilintide backbone (non-acylated)-Gs/β1/γ23.22025-04-16To be published
9BLB (No Gprot) B1PeptideCalcitoninCTHomo sapiensCagrilintide backbone (non-acylated)-3.22025-04-16To be published
9BLCB1PeptideCalcitoninCTHomo sapiensCagrilintide backbone (non-acylated)-Gs/β1/γ23.32025-04-16To be published
9BLC (No Gprot) B1PeptideCalcitoninCTHomo sapiensCagrilintide backbone (non-acylated)-3.32025-04-16To be published
9BUEB1PeptideCalcitoninCTHomo sapiensCagrilintide-Gs/β1/γ23.62025-04-16To be published
9BUE (No Gprot) B1PeptideCalcitoninCTHomo sapiensCagrilintide-3.62025-04-16To be published
9BUCB1PeptideCalcitoninCTHomo sapiensCagrilintide-Gs/β1/γ23.42025-04-23To be published
9BUC (No Gprot) B1PeptideCalcitoninCTHomo sapiensCagrilintide-3.42025-04-23To be published
9BUDB1PeptideCalcitoninCTHomo sapiensCagrilintide-Gs/β1/γ22.52025-04-23To be published
9BUD (No Gprot) B1PeptideCalcitoninCTHomo sapiensCagrilintide-2.52025-04-23To be published
9AUCB1PeptideCalcitoninCT (AMY1)Homo sapiensCalcitonin gene-related peptide-1-Gs/β1/γ2; RAMP12.42024-04-24doi.org/10.1021/acs.biochem.4c00114
9AUC (No Gprot) B1PeptideCalcitoninCT (AMY1)Homo sapiensCalcitonin gene-related peptide-1-2.42024-04-24doi.org/10.1021/acs.biochem.4c00114
7TYFB1PeptideCalcitoninCT (AMY1)Homo sapiensAmylin-Gs/β1/γ2; RAMP12.22022-03-23doi.org/10.1126/science.abm9609
7TYF (No Gprot) B1PeptideCalcitoninCT (AMY1)Homo sapiensAmylin-2.22022-03-23doi.org/10.1126/science.abm9609
7TYWB1PeptideCalcitoninCT (AMY1)Homo sapiensCalcitonin-1-Gs/β1/γ2; RAMP132022-03-23doi.org/10.1126/science.abm9609
7TYW (No Gprot) B1PeptideCalcitoninCT (AMY1)Homo sapiensCalcitonin-1-32022-03-23doi.org/10.1126/science.abm9609
9BLWB1PeptideCalcitoninCT (AMY1)Homo sapiensCagrilintide backbone (non-acylated)-Gs/β1/γ2; RAMP13.22025-04-16To be published
9BLW (No Gprot) B1PeptideCalcitoninCT (AMY1)Homo sapiensCagrilintide backbone (non-acylated)-3.22025-04-16To be published
9BP3B1PeptideCalcitoninCT (AMY1)Homo sapiensCagrilintide-Gs/β1/γ2; RAMP12.22025-04-23To be published
9BP3 (No Gprot) B1PeptideCalcitoninCT (AMY1)Homo sapiensCagrilintide-2.22025-04-23To be published
7TYHB1PeptideCalcitoninCT (AMY2)Homo sapiensCalcitonin-1-Gs/β1/γ2; RAMP23.32022-03-23doi.org/10.1126/science.abm9609
7TYH (No Gprot) B1PeptideCalcitoninCT (AMY2)Homo sapiensCalcitonin-1-3.32022-03-23doi.org/10.1126/science.abm9609
7TYYB1PeptideCalcitoninCT (AMY2)Homo sapiensCalcitonin-1-Gs/β1/γ2; RAMP232022-03-23doi.org/10.1126/science.abm9609
7TYY (No Gprot) B1PeptideCalcitoninCT (AMY2)Homo sapiensCalcitonin-1-32022-03-23doi.org/10.1126/science.abm9609
7TYXB1PeptideCalcitoninCT (AMY2)Homo sapiensAmylin-Gs/β1/γ2; RAMP22.552022-03-30doi.org/10.1126/science.abm9609
7TYX (No Gprot) B1PeptideCalcitoninCT (AMY2)Homo sapiensAmylin-2.552022-03-30doi.org/10.1126/science.abm9609
9BQ3B1PeptideCalcitoninCT (AMY2)Homo sapiensCagrilintide-Gs/β1/γ2; RAMP22.82025-04-23To be published
9BQ3 (No Gprot) B1PeptideCalcitoninCT (AMY2)Homo sapiensCagrilintide-2.82025-04-23To be published
8F0KB1PeptideCalcitoninCT (AMY3)Homo sapiensPramlintide Analogue San385-Gs/β1/γ2; RAMP31.92023-08-02doi.org/10.1038/s41589-023-01393-4
8F0K (No Gprot) B1PeptideCalcitoninCT (AMY3)Homo sapiensPramlintide Analogue San385-1.92023-08-02doi.org/10.1038/s41589-023-01393-4
8F2AB1PeptideCalcitoninCT (AMY3)Homo sapiensPramlintide Analogue San385-Gs/β1/γ2; RAMP32.22023-08-02doi.org/10.1038/s41589-023-01393-4
8F2A (No Gprot) B1PeptideCalcitoninCT (AMY3)Homo sapiensPramlintide Analogue San385-2.22023-08-02doi.org/10.1038/s41589-023-01393-4
8F2BB1PeptideCalcitoninCT (AMY3)Homo sapiensPramlintide Analogue San45-Gs/β1/γ2; RAMP322023-08-02doi.org/10.1038/s41589-023-01393-4
8F2B (No Gprot) B1PeptideCalcitoninCT (AMY3)Homo sapiensPramlintide Analogue San45-22023-08-02doi.org/10.1038/s41589-023-01393-4
7TZFB1PeptideCalcitoninCT (AMY3)Homo sapiensAmylin-Gs/β1/γ2; RAMP32.42022-03-23doi.org/10.1126/science.abm9609
7TZF (No Gprot) B1PeptideCalcitoninCT (AMY3)Homo sapiensAmylin-2.42022-03-23doi.org/10.1126/science.abm9609
9BTWB1PeptideCalcitoninCT (AMY3)Homo sapiensCagrilintide-Gs/β1/γ2; RAMP332025-04-16To be published
9BTW (No Gprot) B1PeptideCalcitoninCT (AMY3)Homo sapiensCagrilintide-32025-04-16To be published
6E3YB1PeptideCalcitoninCT LikeHomo sapiensCalcitonin gene-related peptide-1-Gs/β1/γ2; RAMP13.32018-09-19doi.org/10.1038/s41586-018-0535-y
6E3Y (No Gprot) B1PeptideCalcitoninCT LikeHomo sapiensCalcitonin gene-related peptide-1-3.32018-09-19doi.org/10.1038/s41586-018-0535-y
7KNTB1PeptideCalcitoninCT LikeHomo sapiens--RAMP13.152021-02-24doi.org/10.1126/science.abf7258
7KNUB1PeptideCalcitoninCT LikeHomo sapiensCalcitonin gene-related peptide-1-RAMP13.492021-02-24doi.org/10.1126/science.abf7258
6UUNB1PeptideCalcitoninCT Like (AM1)Homo sapiensAdrenomedullin-Gs/β1/γ2; RAMP232020-03-25doi.org/10.1021/acsptsci.9b00080
6UUN (No Gprot) B1PeptideCalcitoninCT Like (AM1)Homo sapiensAdrenomedullin-32020-03-25doi.org/10.1021/acsptsci.9b00080
6UUSB1PeptideCalcitoninCT Like (AM2)Homo sapiensAdrenomedullin-Gs/β1/γ2; RAMP32.42020-04-01doi.org/10.1021/acsptsci.9b00080
6UUS (No Gprot) B1PeptideCalcitoninCT Like (AM2)Homo sapiensAdrenomedullin-2.42020-04-01doi.org/10.1021/acsptsci.9b00080
6UVAB1PeptideCalcitoninCT Like (AM2)Homo sapiensAdrenomedullin-2-Gs/β1/γ2; RAMP32.32020-04-01doi.org/10.1021/acsptsci.9b00080
6UVA (No Gprot) B1PeptideCalcitoninCT Like (AM2)Homo sapiensAdrenomedullin-2-2.32020-04-01doi.org/10.1021/acsptsci.9b00080
6PH7ASensoryOpsinsRhodopsinBos taurus-NerolGt(CT)2.92020-07-01To be published
6PGSASensoryOpsinsRhodopsinBos taurus-GeraniolGt(CT)2.92020-07-01To be published
6PELASensoryOpsinsRhodopsinBos taurus-CitronellolGt(CT)3.192020-06-24To be published
4J4QASensoryOpsinsRhodopsinBos taurusOctyl β-D-Glucopyranoside-Gt(CT)2.652013-10-30doi.org/10.1002/anie.201302374
4X1HASensoryOpsinsRhodopsinBos taurusNonyl-β-D-Glucopyranoside-Gt(CT)2.292015-11-04doi.org/10.1016/j.str.2015.09.015
4BEYASensoryOpsinsRhodopsinBos taurus--Gt(CT)2.92013-05-08doi.org/10.1038/embor.2013.44
3DQBASensoryOpsinsRhodopsinBos taurus--Gt(CT)3.22008-09-23doi.org/10.1038/nature07330
3PQRASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal-Gt(CT)2.852011-03-09doi.org/10.1038/nature09789
2X72ASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal-Gt(CT)32011-03-16doi.org/10.1038/nature09795
5WKTASensoryOpsinsRhodopsinBos taurusOctyl-β-D-Glucopyranoside-Gt(CT)3.22017-12-13doi.org/10.1038/nprot.2017.135
4A4MASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal-Gt(CT)3.32012-01-25doi.org/10.1073/pnas.1114089108
5EN0ASensoryOpsinsRhodopsinBos taurusAll-trans-Retinal-Gt(CT)2.812016-08-10doi.org/10.15252/embr.201642671
6NWEASensoryOpsinsRhodopsinBos taurusOctyl-β-D-Glucopyranoside-Gt(CT)2.712020-02-12To be published
6TP4APeptideOrexinOX1Homo sapiensACT-462206--3.012020-01-01doi.org/10.1021/acs.jmedchem.9b01787




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