psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:K1	R:R:V293	4.55	No	No	0	0	6
2	L:L:K1	R:R:E294	4.05	No	No	0	0	3
3	L:L:C2	L:L:T4	5.07	Yes	Yes	6	0	0
4	L:L:C2	L:L:C7	7.28	Yes	Yes	6	0	0
5	L:L:C2	L:L:R11	2.79	Yes	No	6	0	0
6	L:L:C2	R:R:Y299	4.03	Yes	No	0	0	7
7	L:L:N3	R:R:W361	11.3	No	No	0	0	4
8	L:L:T4	L:L:T6	3.14	Yes	No	0	0	0
9	L:L:C7	L:L:T4	3.38	Yes	Yes	6	0	0
10	L:L:T4	R:R:M306	3.01	Yes	No	0	0	4
11	L:L:A5	R:R:M376	3.22	No	Yes	0	0	7
12	L:L:T6	R:R:H302	10.95	No	No	0	0	6
13	L:L:C7	L:L:R11	6.96	Yes	No	6	0	0
14	L:L:C7	R:R:H302	7.37	Yes	No	0	0	6
15	L:L:A8	R:R:H377	4.39	No	Yes	0	0	7
16	L:L:T9	R:R:I198	3.04	No	No	0	0	7
17	L:L:Q10	R:R:H223	4.95	No	Yes	0	0	5
18	L:L:L12	L:L:L16	6.92	No	No	0	0	0
19	L:L:L12	R:R:L148	2.77	No	No	11	0	5
20	L:L:L12	R:R:H377	3.86	No	Yes	11	0	7
21	L:L:E14	L:L:H18	9.85	No	No	0	0	0
22	L:L:E14	R:R:V293	4.28	No	No	0	0	6
23	L:L:F15	L:L:L16	3.65	No	No	0	0	0
24	L:L:F15	R:R:F137	6.43	No	No	0	0	1
25	L:L:F15	R:R:A145	2.77	No	No	0	0	4
26	L:L:L16	R:R:Y149	3.52	No	Yes	0	0	5
27	L:L:H18	L:L:R17	7.9	No	No	0	0	0
28	L:L:R17	R:R:L291	8.5	No	No	0	0	6
29	L:L:S19	R:R:F137	14.53	No	No	0	0	1
30	L:L:S19	R:R:L142	6.01	No	No	0	0	2
31	L:L:N21	L:L:S20	8.94	No	No	0	0	0
32	L:L:N22	L:L:P28	4.89	No	No	0	0	0
33	L:L:T30	R:R:D101	7.23	No	No	0	0	4
34	L:L:G33	L:L:N31	3.39	No	No	0	0	0
35	L:L:N31	L:L:S34	5.96	No	No	0	0	0
36	L:L:N31	L:L:T36	11.7	No	No	0	0	0
37	L:L:V32	R:R:T132	4.76	No	No	0	0	6
38	L:L:G33	R:R:W128	5.63	No	Yes	0	0	5
39	L:L:N35	L:L:S34	5.96	No	No	0	0	0
40	L:L:N35	L:L:T36	4.39	No	No	0	0	0
41	L:L:?38	L:L:P37	8.13	Yes	Yes	1	0	0
42	L:L:P37	R:R:D77	4.83	Yes	Yes	1	0	9
43	L:L:P37	R:R:G78	4.06	Yes	No	1	0	5
44	L:L:P37	R:R:W79	9.46	Yes	Yes	1	0	6
45	L:L:?38	R:R:D77	10.08	Yes	Yes	1	0	9
46	L:L:?38	R:R:W128	8.46	Yes	Yes	0	0	5
47	L:L:?38	R:R:S129	7.43	Yes	Yes	1	0	7
48	L:L:?38	R:R:Y131	11.61	Yes	Yes	1	0	5
49	R:R:P38	R:R:R213	4.32	No	No	0	5	2
50	R:R:F39	R:R:V43	7.87	No	No	0	4	2
51	R:R:F285	R:R:F39	9.65	Yes	No	0	6	4
52	R:R:K46	R:R:V42	3.04	No	No	0	4	1
53	R:R:K47	R:R:Y98	7.17	No	Yes	0	4	4
54	R:R:M48	R:R:W79	4.65	No	Yes	0	6	6
55	R:R:A51	R:R:K54	3.21	No	No	0	8	4
56	R:R:Q52	R:R:W76	3.29	No	No	0	6	8
57	R:R:C55	R:R:R58	6.96	No	Yes	8	9	3
58	R:R:C55	R:R:W76	5.22	No	No	8	9	8
59	R:R:C55	R:R:C81	7.28	No	Yes	8	9	9
60	R:R:C81	R:R:R58	2.79	Yes	Yes	8	9	3
61	R:R:M59	R:R:R74	4.96	No	No	0	5	4
62	R:R:L62	R:R:P63	4.93	No	No	0	3	1
63	R:R:D84	R:R:L62	4.07	No	No	0	4	3
64	R:R:P70	R:R:Y71	2.78	No	No	0	1	3
65	R:R:D84	R:R:Y71	3.45	No	No	0	4	3
66	R:R:P86	R:R:Y71	20.86	No	No	0	2	3
67	R:R:C112	R:R:C72	7.28	No	No	0	9	9
68	R:R:C81	R:R:R74	2.79	Yes	No	0	9	4
69	R:R:D84	R:R:R74	13.1	No	No	0	4	4
70	R:R:T75	R:R:W118	6.06	No	Yes	0	5	9
71	R:R:C81	R:R:W76	6.53	Yes	No	8	9	8
72	R:R:D77	R:R:G78	5.03	Yes	No	1	9	5
73	R:R:D77	R:R:S129	5.89	Yes	Yes	1	9	7
74	R:R:D77	R:R:Y131	9.2	Yes	Yes	1	9	5
75	R:R:G78	R:R:W79	4.22	No	Yes	1	5	6
76	R:R:W79	R:R:Y131	7.72	Yes	Yes	1	6	5
77	R:R:L80	R:R:Q93	6.65	No	No	0	5	6
78	R:R:L80	R:R:P96	6.57	No	No	3	5	9
79	R:R:L80	R:R:Y98	3.52	No	Yes	3	5	4
80	R:R:Q93	R:R:W82	13.14	No	Yes	0	6	9
81	R:R:V108	R:R:W82	3.68	No	Yes	0	7	9
82	R:R:K110	R:R:W82	5.8	Yes	Yes	1	8	9
83	R:R:W118	R:R:W82	12.18	Yes	Yes	1	9	9
84	R:R:D83	R:R:T85	4.34	No	Yes	0	5	7
85	R:R:G88	R:R:T85	3.64	No	Yes	0	8	7
86	R:R:S91	R:R:T85	6.4	No	Yes	0	5	7
87	R:R:T85	R:R:W118	4.85	Yes	Yes	0	7	9
88	R:R:L90	R:R:V89	4.47	No	No	0	4	5
89	R:R:V89	R:R:Y111	3.79	No	No	0	5	4
90	R:R:L90	R:R:T109	7.37	No	No	0	4	5
91	R:R:K107	R:R:Y92	13.14	No	No	0	3	4
92	R:R:C95	R:R:P96	3.77	Yes	No	3	9	9
93	R:R:C95	R:R:F102	2.79	Yes	Yes	3	9	4
94	R:R:C95	R:R:E106	3.04	Yes	Yes	3	9	4
95	R:R:C134	R:R:C95	5.46	No	Yes	3	9	9
96	R:R:P96	R:R:Y98	8.34	No	Yes	3	9	4
97	R:R:D97	R:R:P104	6.44	No	No	0	2	3
98	R:R:F99	R:R:Y98	4.13	No	Yes	0	5	4
99	R:R:F102	R:R:F99	8.57	Yes	No	0	4	5
100	R:R:D101	R:R:F137	5.97	No	No	0	4	1
101	R:R:C134	R:R:F102	2.79	No	Yes	3	9	4
102	R:R:D103	R:R:S105	7.36	Yes	No	0	3	1
103	R:R:A136	R:R:D103	6.18	No	Yes	0	2	3
104	R:R:E106	R:R:V108	2.85	Yes	No	0	4	7
105	R:R:E106	R:R:M133	6.77	Yes	No	0	4	5
106	R:R:C134	R:R:E106	10.64	No	Yes	3	9	4
107	R:R:V108	R:R:Y131	11.36	No	Yes	0	7	5
108	R:R:K110	R:R:W118	20.89	Yes	Yes	1	8	9
109	R:R:F119	R:R:K110	6.2	No	Yes	0	4	8
110	R:R:K110	R:R:T127	3	Yes	No	1	8	4
111	R:R:K110	R:R:S129	4.59	Yes	Yes	1	8	7
112	R:R:F119	R:R:Y111	8.25	No	No	0	4	4
113	R:R:C112	R:R:W118	6.53	No	Yes	0	9	9
114	R:R:T127	R:R:W118	3.64	No	Yes	1	4	9
115	R:R:F119	R:R:W128	3.01	No	Yes	0	4	5
116	R:R:K120	R:R:P122	5.02	No	No	0	1	5
117	R:R:H121	R:R:P122	6.1	Yes	No	0	4	5
118	R:R:E123	R:R:H121	4.92	No	Yes	0	4	4
119	R:R:H121	R:R:N124	6.38	Yes	No	0	4	5
120	R:R:H121	R:R:W128	24.33	Yes	Yes	0	4	5
121	R:R:N124	R:R:R126	6.03	No	No	0	5	4
122	R:R:N130	R:R:W128	6.78	No	Yes	0	8	5
123	R:R:S129	R:R:Y131	12.72	Yes	Yes	1	7	5
124	R:R:N130	R:R:T132	4.39	No	No	0	8	6
125	R:R:M133	R:R:T132	3.01	No	No	0	5	6
126	R:R:N135	R:R:T138	5.85	No	Yes	0	3	2
127	R:R:P139	R:R:T138	3.5	No	Yes	0	3	2
128	R:R:K141	R:R:T138	12.01	No	Yes	0	3	2
129	R:R:Y146	R:R:Y150	13.9	No	No	0	2	4
130	R:R:V147	R:R:Y374	3.79	No	Yes	0	4	6
131	R:R:H377	R:R:L148	7.71	Yes	No	11	7	5
132	R:R:Y149	R:R:Y150	10.92	Yes	No	0	5	4
133	R:R:I153	R:R:Y149	6.04	No	Yes	0	7	5
134	R:R:L202	R:R:Y149	3.52	No	Yes	0	7	5
135	R:R:A152	R:R:H381	7.32	No	No	0	7	9
136	R:R:G155	R:R:V154	3.68	No	No	0	8	6
137	R:R:F382	R:R:G155	9.03	Yes	No	0	7	8
138	R:R:H156	R:R:S195	9.76	Yes	No	0	7	7
139	R:R:H156	R:R:I198	11.93	Yes	No	0	7	7
140	R:R:H156	R:R:H381	9.55	Yes	No	0	7	9
141	R:R:L158	R:R:T162	2.95	No	Yes	12	4	6
142	R:R:F385	R:R:L158	7.31	No	No	12	5	4
143	R:R:G384	R:R:S159	3.71	No	No	0	9	9
144	R:R:I160	R:R:S195	3.1	No	No	0	5	7
145	R:R:F385	R:R:T162	9.08	No	Yes	12	5	6
146	R:R:A388	R:R:T162	3.36	No	Yes	0	8	6
147	R:R:F393	R:R:T162	3.89	Yes	Yes	0	8	6
148	R:R:F188	R:R:L163	4.87	Yes	No	0	8	8
149	R:R:I192	R:R:L163	5.71	No	No	0	7	8
150	R:R:A388	R:R:L163	3.15	No	No	0	8	8
151	R:R:F393	R:R:I165	3.77	Yes	No	0	8	5
152	R:R:F188	R:R:S166	3.96	Yes	No	0	8	9
153	R:R:A388	R:R:S166	3.42	No	No	0	8	9
154	R:R:C392	R:R:S166	6.89	Yes	No	0	9	9
155	R:R:K185	R:R:L167	2.82	Yes	No	0	6	6
156	R:R:F188	R:R:L167	3.65	Yes	No	0	8	6
157	R:R:F170	R:R:V181	9.18	No	No	0	8	9
158	R:R:F170	R:R:F188	6.43	No	Yes	0	8	8
159	R:R:C392	R:R:F170	5.59	Yes	No	0	9	8
160	R:R:F172	R:R:F173	8.57	No	Yes	0	2	7
161	R:R:F173	R:R:L176	3.65	Yes	Yes	13	7	9
162	R:R:F173	R:R:T401	3.89	Yes	No	13	7	7
163	R:R:F173	R:R:Q405	10.54	Yes	No	0	7	4
164	R:R:L176	R:R:S175	3	Yes	No	0	9	8
165	R:R:L176	R:R:V398	4.47	Yes	No	0	9	9
166	R:R:L176	R:R:T401	10.32	Yes	No	13	9	7
167	R:R:G177	R:R:V181	5.52	No	No	0	7	9
168	R:R:Q179	R:R:T182	4.25	Yes	Yes	4	7	5
169	R:R:Q179	R:R:Y243	7.89	Yes	Yes	4	7	8
170	R:R:L259	R:R:Q179	11.98	Yes	Yes	4	5	7
171	R:R:H184	R:R:R180	6.77	Yes	No	0	9	9
172	R:R:K185	R:R:V181	4.55	Yes	No	0	6	9
173	R:R:L183	R:R:T182	2.95	Yes	Yes	4	8	5
174	R:R:K185	R:R:T182	4.5	Yes	Yes	0	6	5
175	R:R:L259	R:R:T182	2.95	Yes	Yes	4	5	5
176	R:R:L183	R:R:W236	3.42	Yes	Yes	0	8	9
177	R:R:L183	R:R:Y243	7.03	Yes	Yes	4	8	8
178	R:R:L183	R:R:L259	2.77	Yes	Yes	4	8	5
179	R:R:L183	R:R:Y262	3.52	Yes	Yes	4	8	7
180	R:R:F188	R:R:H184	5.66	Yes	Yes	0	8	9
181	R:R:E240	R:R:H184	11.08	No	Yes	0	9	9
182	R:R:H184	R:R:Y391	5.44	Yes	No	0	9	8
183	R:R:N186	R:R:W236	9.04	No	Yes	0	9	9
184	R:R:N186	R:R:Y263	10.47	No	No	0	9	5
185	R:R:M187	R:R:Y191	4.79	No	Yes	0	8	8
186	R:R:E240	R:R:M187	6.77	No	No	0	9	8
187	R:R:L189	R:R:L193	4.15	No	No	0	3	6
188	R:R:L189	R:R:W267	3.42	No	No	0	3	9
189	R:R:C232	R:R:T190	3.38	Yes	No	0	8	9
190	R:R:N233	R:R:T190	5.85	No	No	0	9	9
191	R:R:N233	R:R:Y191	17.44	No	Yes	0	9	8
192	R:R:Q383	R:R:Y191	11.27	Yes	Yes	0	9	8
193	R:R:G384	R:R:Y191	2.9	No	Yes	0	9	8
194	R:R:V387	R:R:Y191	6.31	No	Yes	0	9	8
195	R:R:L193	R:R:M229	5.65	No	Yes	0	6	4
196	R:R:M229	R:R:N194	5.61	Yes	No	0	4	8
197	R:R:M230	R:R:N194	4.21	No	No	0	6	8
198	R:R:N194	R:R:N233	8.17	No	No	0	8	9
199	R:R:H226	R:R:I197	3.98	Yes	No	0	6	5
200	R:R:I197	R:R:M229	4.37	No	Yes	0	5	4
201	R:R:H226	R:R:I198	3.98	Yes	No	0	6	7
202	R:R:E204	R:R:I200	4.1	No	No	0	4	6
203	R:R:H201	R:R:V205	6.92	Yes	No	0	6	7
204	R:R:H201	R:R:V206	2.77	Yes	No	0	6	3
205	R:R:H201	R:R:H223	3.58	Yes	Yes	7	6	5
206	R:R:H201	R:R:H226	4.78	Yes	Yes	7	6	6
207	R:R:H201	R:R:L291	7.71	Yes	No	7	6	6
208	R:R:P207	R:R:V206	3.53	No	No	0	3	3
209	R:R:N208	R:R:P207	3.26	No	No	0	3	3
210	R:R:E210	R:R:N208	6.57	No	No	0	3	3
211	R:R:L211	R:R:N208	9.61	No	No	0	1	3
212	R:R:C289	R:R:V212	6.83	No	No	0	9	3
213	R:R:D215	R:R:N288	13.46	No	No	0	6	4
214	R:R:C219	R:R:P216	3.77	No	No	0	9	4
215	R:R:C219	R:R:C289	7.28	No	No	0	9	9
216	R:R:K220	R:R:N286	5.6	No	No	2	7	7
217	R:R:K220	R:R:W290	8.12	No	Yes	2	7	9
218	R:R:H223	R:R:H226	7.17	Yes	Yes	7	5	6
219	R:R:H223	R:R:Q227	9.89	Yes	No	0	5	7
220	R:R:H223	R:R:L291	7.71	Yes	No	7	5	6
221	R:R:F224	R:R:T274	6.49	No	No	0	5	6
222	R:R:A278	R:R:F224	2.77	No	No	0	6	5
223	R:R:F225	R:R:M229	3.73	No	Yes	0	5	4
224	R:R:H277	R:R:Q227	11.13	No	No	0	7	7
225	R:R:C232	R:R:Y228	5.38	Yes	Yes	5	8	8
226	R:R:P270	R:R:Y228	2.78	Yes	Yes	5	9	8
227	R:R:L271	R:R:Y228	12.89	No	Yes	0	4	8
228	R:R:T274	R:R:Y228	6.24	No	Yes	0	6	8
229	R:R:M230	R:R:Y234	4.79	No	Yes	0	6	7
230	R:R:H302	R:R:M230	5.25	No	No	0	6	6
231	R:R:A231	R:R:F235	2.77	No	Yes	0	5	5
232	R:R:A231	R:R:I301	3.25	No	No	0	5	7
233	R:R:C232	R:R:W267	3.92	Yes	No	0	8	9
234	R:R:C232	R:R:P270	5.65	Yes	Yes	5	8	9
235	R:R:M237	R:R:Y234	7.18	Yes	Yes	0	9	7
236	R:R:V305	R:R:Y234	5.05	No	Yes	0	7	7
237	R:R:F356	R:R:Y234	10.32	Yes	Yes	0	7	7
238	R:R:F235	R:R:F269	6.43	Yes	No	5	5	3
239	R:R:F235	R:R:P270	8.67	Yes	Yes	5	5	9
240	R:R:F235	R:R:P304	2.89	Yes	No	0	5	9
241	R:R:F235	R:R:V305	3.93	Yes	No	0	5	7
242	R:R:A308	R:R:F235	2.77	No	Yes	0	7	5
243	R:R:C239	R:R:W236	5.22	No	Yes	0	7	9
244	R:R:G266	R:R:W236	8.44	No	Yes	0	9	9
245	R:R:W236	R:R:W267	14.06	Yes	No	0	9	9
246	R:R:L309	R:R:M237	2.83	No	Yes	0	7	9
247	R:R:G353	R:R:M237	3.49	No	Yes	0	9	9
248	R:R:M237	R:R:Q383	4.08	Yes	Yes	0	9	9
249	R:R:I242	R:R:L238	7.14	No	No	0	7	8
250	R:R:A308	R:R:L238	4.73	No	No	0	7	8
251	R:R:L238	R:R:V311	2.98	No	No	0	8	6
252	R:R:C239	R:R:L265	4.76	No	No	0	7	7
253	R:R:E240	R:R:L351	14.58	No	No	0	9	9
254	R:R:G241	R:R:N312	3.39	No	No	0	8	9
255	R:R:I242	R:R:Y262	4.84	No	Yes	0	7	7
256	R:R:F315	R:R:I242	3.77	No	No	0	8	7
257	R:R:L247	R:R:Y243	12.89	No	Yes	0	8	8
258	R:R:Q257	R:R:Y243	5.64	No	Yes	4	5	8
259	R:R:Y243	R:R:Y262	7.94	Yes	Yes	4	8	7
260	R:R:I319	R:R:L244	4.28	No	No	0	9	9
261	R:R:L244	R:R:L348	2.77	No	No	0	9	9
262	R:R:H245	R:R:V249	6.92	Yes	No	14	8	6
263	R:R:H245	R:R:V250	6.92	Yes	No	14	8	5
264	R:R:F315	R:R:H245	15.84	No	Yes	0	8	8
265	R:R:H245	R:R:N318	8.93	Yes	No	0	8	8
266	R:R:L247	R:R:T246	2.95	No	No	0	8	7
267	R:R:Q257	R:R:T246	8.5	No	No	0	5	7
268	R:R:I248	R:R:I319	2.94	No	No	0	7	9
269	R:R:I248	R:R:V322	3.07	No	No	0	7	8
270	R:R:V249	R:R:V250	6.41	No	No	14	6	5
271	R:R:V249	R:R:V322	3.21	No	No	0	6	8
272	R:R:Q257	R:R:Y262	3.38	No	Yes	4	5	7
273	R:R:R258	R:R:R260	11.73	No	No	0	5	3
274	R:R:L259	R:R:Y262	3.52	Yes	Yes	4	5	7
275	R:R:L259	R:R:Y263	4.69	Yes	No	0	5	5
276	R:R:R260	R:R:W261	5	No	No	0	3	2
277	R:R:F269	R:R:L265	6.09	No	No	0	3	7
278	R:R:F269	R:R:P270	2.89	No	Yes	5	3	9
279	R:R:P273	R:R:V272	3.53	No	No	0	6	4
280	R:R:I301	R:R:T274	3.04	No	No	0	7	6
281	R:R:H277	R:R:R281	13.54	No	Yes	0	7	7
282	R:R:H277	R:R:L298	5.14	No	No	0	7	6
283	R:R:L297	R:R:T280	7.37	Yes	No	0	4	4
284	R:R:F285	R:R:R281	7.48	Yes	Yes	2	6	7
285	R:R:R281	R:R:W290	15.99	Yes	Yes	2	7	9
286	R:R:R281	R:R:T295	5.17	Yes	No	2	7	4
287	R:R:L297	R:R:R281	6.07	Yes	Yes	2	4	7
288	R:R:V283	R:R:Y284	6.31	No	No	0	3	2
289	R:R:D287	R:R:F285	4.78	Yes	Yes	2	3	6
290	R:R:F285	R:R:S292	5.28	Yes	No	2	6	4
291	R:R:F285	R:R:T295	12.97	Yes	No	2	6	4
292	R:R:N286	R:R:W290	9.04	No	Yes	2	7	9
293	R:R:D287	R:R:N288	5.39	Yes	No	0	3	4
294	R:R:D287	R:R:S292	5.89	Yes	No	2	3	4
295	R:R:E294	R:R:S292	2.87	No	No	0	3	4
296	R:R:L298	R:R:V293	2.98	No	No	0	6	6
297	R:R:L297	R:R:T295	4.42	Yes	No	2	4	4
298	R:R:H296	R:R:L297	6.43	No	Yes	0	2	4
299	R:R:G303	R:R:P304	4.06	No	No	0	4	9
300	R:R:F356	R:R:L309	3.65	Yes	No	0	7	7
301	R:R:F315	R:R:V311	5.24	No	No	0	8	6
302	R:R:L352	R:R:N312	16.48	No	No	0	9	9
303	R:R:F313	R:R:I354	3.77	No	No	0	6	6
304	R:R:L316	R:R:V320	2.98	Yes	No	0	9	7
305	R:R:L316	R:R:L348	2.77	Yes	No	0	9	9
306	R:R:L316	R:R:L352	2.77	Yes	No	0	9	9
307	R:R:I354	R:R:L316	4.28	No	Yes	0	6	9
308	R:R:L323	R:R:M327	2.83	No	No	0	9	7
309	R:R:R328	R:R:V324	3.92	No	No	0	6	5
310	R:R:M327	R:R:M337	4.33	No	No	0	7	7
311	R:R:K340	R:R:M327	5.76	No	No	0	8	7
312	R:R:A333	R:R:E332	3.02	No	No	0	5	5
313	R:R:E332	R:R:H336	12.31	No	No	0	5	6
314	R:R:E334	R:R:M337	4.06	No	No	0	6	7
315	R:R:E334	R:R:Y338	11.22	No	No	0	6	7
316	R:R:H336	R:R:K340	7.86	No	No	0	6	8
317	R:R:I347	R:R:I390	4.42	No	No	0	8	8
318	R:R:P350	R:R:V349	3.53	No	No	0	9	8
319	R:R:I354	R:R:V349	6.14	No	No	0	6	8
320	R:R:Q355	R:R:V349	4.3	Yes	No	0	8	8
321	R:R:F386	R:R:P350	2.89	No	No	0	5	9
322	R:R:L351	R:R:Y391	16.41	No	No	0	9	8
323	R:R:G353	R:R:Q355	3.29	No	Yes	9	9	8
324	R:R:F356	R:R:G353	3.01	Yes	No	9	7	9
325	R:R:F356	R:R:Q355	11.71	Yes	Yes	9	7	8
326	R:R:M376	R:R:Q355	4.08	Yes	Yes	0	7	8
327	R:R:L379	R:R:Q355	3.99	No	Yes	0	5	8
328	R:R:Q355	R:R:Q383	7.68	Yes	Yes	9	8	9
329	R:R:F356	R:R:I380	7.54	Yes	No	0	7	6
330	R:R:F356	R:R:Q383	5.86	Yes	Yes	9	7	9
331	R:R:F359	R:R:V358	13.11	No	No	0	6	5
332	R:R:F359	R:R:M376	4.98	No	Yes	0	6	7
333	R:R:P363	R:R:R362	2.88	Yes	Yes	10	7	4
334	R:R:G369	R:R:R362	4.5	No	Yes	10	4	4
335	R:R:R362	R:R:Y372	5.14	Yes	No	10	4	7
336	R:R:D373	R:R:R362	14.29	No	Yes	0	5	4
337	R:R:L368	R:R:P363	11.49	No	Yes	0	3	7
338	R:R:G369	R:R:P363	4.06	No	Yes	10	4	7
339	R:R:P363	R:R:Y372	6.95	Yes	No	10	7	7
340	R:R:M367	R:R:N365	4.21	No	No	0	4	4
341	R:R:L368	R:R:N365	5.49	No	No	0	3	4
342	R:R:K370	R:R:Y374	3.58	No	Yes	0	4	6
343	R:R:I371	R:R:V375	3.07	No	No	0	5	4
344	R:R:I380	R:R:M376	5.83	No	Yes	0	6	7
345	R:R:H377	R:R:H381	9.55	Yes	No	0	7	9
346	R:R:F382	R:R:F386	3.22	Yes	No	0	7	5
347	R:R:I390	R:R:T389	3.04	No	No	0	8	5
348	R:R:F393	R:R:T389	3.89	Yes	No	0	8	5
349	R:R:I390	R:R:Y391	7.25	No	No	0	8	8
350	R:R:C392	R:R:F393	4.19	Yes	Yes	0	9	8
351	R:R:E397	R:R:N395	17.09	No	No	0	9	9
352	R:R:N395	R:R:V398	10.35	No	No	0	9	9
353	R:R:Q408	R:R:R404	4.67	No	No	0	7	7
354	R:R:K410	R:R:W406	9.28	No	No	0	4	6
355	R:R:I411	R:R:K410	2.91	No	No	0	4	4
356	R:R:D287	R:R:L40	2.71	Yes	No	0	3	5
357	R:R:A51	R:R:Y98	2.67	No	Yes	0	8	4
358	R:R:H156	R:R:I199	2.65	Yes	No	0	7	7
359	L:L:R17	R:R:V212	2.62	No	No	0	0	3
360	L:L:T30	R:R:F102	2.59	No	Yes	0	0	4
361	R:R:A282	R:R:W290	2.59	No	Yes	0	3	9
362	R:R:Q405	R:R:Q408	2.56	No	No	0	4	7
363	R:R:E255	R:R:Q179	2.55	No	Yes	0	6	7
364	R:R:F173	R:R:I169	2.51	Yes	No	0	7	8
365	R:R:T109	R:R:Y92	2.5	No	No	0	5	4
366	R:R:K54	R:R:R58	2.48	No	Yes	0	4	3
367	R:R:M337	R:R:R328	2.48	No	No	0	7	6
368	R:R:F382	R:R:L151	2.44	Yes	No	0	7	5
369	R:R:F313	R:R:L317	2.44	No	No	0	6	5
370	R:R:M59	R:R:Y56	2.39	No	No	0	5	3
371	R:R:M376	R:R:Y372	2.39	Yes	No	0	7	7
372	R:R:L148	R:R:Y374	2.34	No	Yes	0	5	6
373	R:R:F313	R:R:F314	2.14	No	No	0	6	5
374	R:R:G268	R:R:P270	2.03	No	Yes	0	6	9
375	R:R:F409	R:R:W406	2	No	No	0	3	6
376	R:R:C178	R:R:G177	1.96	No	No	0	8	7
377	L:L:P28	L:L:P29	1.95	No	No	0	0	0
378	R:R:G44	R:R:V43	1.84	No	No	0	4	2
379	R:R:G168	R:R:V171	1.84	No	No	0	1	4
380	R:R:G268	R:R:L264	1.71	No	No	0	6	3
381	L:L:A13	R:R:V206	1.7	No	No	0	0	3
382	R:R:A251	R:R:V250	1.7	No	No	0	6	5
383	R:R:I301	R:R:P273	1.69	No	No	0	7	6
384	R:R:L40	R:R:P38	1.64	No	No	0	5	5
385	R:R:C392	R:R:I169	1.64	Yes	No	0	9	8
386	R:R:D103	R:R:P104	1.61	Yes	No	0	3	3
387	R:R:V310	R:R:V357	1.6	No	No	0	4	7
388	R:R:T345	R:R:V320	1.59	No	No	0	9	7
389	R:R:T325	R:R:V324	1.59	No	No	0	7	5
390	R:R:A344	R:R:L323	1.58	No	No	0	9	9
391	R:R:T400	R:R:T401	1.57	No	No	0	4	7
392	R:R:C112	R:R:D113	1.56	No	No	0	9	5
393	R:R:I199	R:R:S157	1.55	No	No	0	7	7
394	R:R:I153	R:R:V203	1.54	No	No	0	7	3
395	R:R:I165	R:R:V164	1.54	No	No	0	5	4
396	R:R:I276	R:R:V272	1.54	No	No	0	5	4
397	R:R:K185	R:R:V171	1.52	Yes	No	0	6	4
398	R:R:L309	R:R:V357	1.49	No	No	0	7	7
399	R:R:I276	R:R:I279	1.47	No	No	0	5	3
400	R:R:I276	R:R:I300	1.47	No	No	0	5	8
401	R:R:N396	R:R:T400	1.46	No	No	0	6	4
402	R:R:F99	R:R:P100	1.44	No	No	0	5	4
403	R:R:F359	R:R:P360	1.44	No	No	0	6	5
404	R:R:K366	R:R:M367	1.44	No	No	0	3	4
405	R:R:E204	R:R:V203	1.43	No	No	0	4	3
406	R:R:E140	R:R:T138	1.41	No	Yes	0	2	2
407	R:R:L193	R:R:M196	1.41	No	No	0	6	4
408	R:R:E329	R:R:T325	1.41	No	No	0	6	7
409	R:R:K340	R:R:L339	1.41	No	No	0	8	6
410	L:L:K1	L:L:N3	1.4	No	No	0	0	0
411	R:R:K141	R:R:N144	1.4	No	No	0	3	4
412	L:L:P28	R:R:Y41	1.39	No	No	0	0	3
413	R:R:D50	R:R:K54	1.38	No	No	0	2	4
414	R:R:M49	R:R:Q52	1.36	No	No	0	4	6
415	R:R:E255	R:R:K256	1.35	No	No	0	6	5
416	R:R:L62	R:R:Q61	1.33	No	No	0	3	3
417	R:R:F382	R:R:S378	1.32	Yes	No	0	7	5
418	R:R:D57	R:R:Q60	1.31	No	No	0	4	3
419	R:R:R321	R:R:V322	1.31	No	No	0	8	8
420	R:R:D103	R:R:E106	1.3	Yes	Yes	0	3	4
421	R:R:F161	R:R:T162	1.3	No	Yes	0	4	6
422	R:R:F224	R:R:T275	1.3	No	No	0	5	3
423	R:R:T280	R:R:Y284	1.25	No	No	0	4	2
424	R:R:K256	R:R:R258	1.24	No	No	0	5	5
425	R:R:L211	R:R:R214	1.21	No	No	0	1	4
426	R:R:D57	R:R:R58	1.19	No	Yes	0	4	3
427	R:R:F94	R:R:Q93	1.17	No	No	0	3	6
428	R:R:N144	R:R:Y374	1.16	No	Yes	0	4	6
429	R:R:Q52	R:R:Y53	1.13	No	No	0	6	1
430	R:R:F409	R:R:W413	1	No	No	0	3	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:C2	4.7925	4	6	0
2	L:L:T4	3.65	4	6	0
3	L:L:C7	6.2475	4	6	0
4	L:L:P37	6.62	4	1	0
5	L:L:?38	9.142	5	1	0
6	R:R:R58	3.355	4	8	3
7	R:R:D77	7.006	5	1	9
8	R:R:W79	6.5125	4	1	6
9	R:R:C81	4.8475	4	8	9
10	R:R:W82	8.7	4	1	9
11	R:R:T85	4.8075	4	0	7
12	R:R:C95	3.765	4	3	9
13	R:R:Y98	5.166	5	3	4
14	R:R:F102	4.185	4	3	4
15	R:R:D103	4.1125	4	0	3
16	R:R:E106	4.92	5	3	4
17	R:R:K110	8.096	5	1	8
18	R:R:W118	9.025	6	1	9
19	R:R:H121	10.4325	4	0	4
20	R:R:W128	9.642	5	0	5
21	R:R:S129	7.6575	4	1	7
22	R:R:Y131	10.522	5	1	5
23	R:R:T138	5.6925	4	0	2
24	R:R:Y149	6	4	0	5
25	R:R:H156	8.4725	4	0	7
26	R:R:T162	4.116	5	12	6
27	R:R:F173	5.832	5	13	7
28	R:R:L176	5.36	4	13	9
29	R:R:Q179	6.6675	4	4	7
30	R:R:T182	3.6625	4	4	5
31	R:R:L183	3.938	5	4	8
32	R:R:H184	7.2375	4	0	9
33	R:R:K185	3.3475	4	0	6
34	R:R:F188	4.914	5	0	8
35	R:R:Y191	8.542	5	0	8
36	R:R:H201	5.152	5	7	6
37	R:R:H223	6.66	5	7	5
38	R:R:H226	4.9775	4	7	6
39	R:R:Y228	6.8225	4	5	8
40	R:R:M229	4.84	4	0	4
41	R:R:C232	4.5825	4	5	8
42	R:R:Y234	6.835	4	0	7
43	R:R:F235	4.57667	6	5	5
44	R:R:W236	8.036	5	0	9
45	R:R:M237	4.395	4	0	9
46	R:R:Y243	8.278	5	4	8
47	R:R:H245	9.6525	4	14	8
48	R:R:L259	5.182	5	4	5
49	R:R:Y262	4.64	5	4	7
50	R:R:P270	4.404	5	5	9
51	R:R:R281	9.65	5	2	7
52	R:R:F285	8.032	5	2	6
53	R:R:D287	4.6925	4	2	3
54	R:R:W290	8.935	4	2	9
55	R:R:L297	6.0725	4	2	4
56	R:R:L316	3.2	4	0	9
57	R:R:Q355	5.84167	6	9	8
58	R:R:F356	7.015	6	9	7
59	R:R:R362	6.7025	4	10	4
60	R:R:P363	6.345	4	10	7
61	R:R:Y374	2.7175	4	0	6
62	R:R:M376	4.1	5	0	7
63	R:R:H377	6.3775	4	11	7
64	R:R:F382	4.0025	4	0	7
65	R:R:Q383	7.2225	4	9	9
66	R:R:C392	4.5775	4	0	9
67	R:R:F393	3.935	4	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:M230	R:R:N194	33.135	4.21	No	No	0	6	8
2	R:R:M229	R:R:N194	76.6803	5.61	Yes	No	0	4	8
3	R:R:I197	R:R:M229	100	4.37	No	Yes	0	5	4
4	R:R:H226	R:R:I197	99.9649	3.98	Yes	No	0	6	5
5	R:R:H223	R:R:H226	25.6629	7.17	Yes	Yes	7	5	6
6	R:R:H223	R:R:Q227	19.9826	9.89	Yes	No	0	5	7
7	R:R:H277	R:R:Q227	19.372	11.13	No	No	0	7	7
8	R:R:M376	R:R:Q355	14.4305	4.08	Yes	Yes	0	7	8
9	R:R:F356	R:R:Q355	16.2127	11.71	Yes	Yes	9	7	8
10	R:R:F356	R:R:Y234	25.5529	10.32	Yes	Yes	0	7	7
11	R:R:M230	R:R:Y234	29.1584	4.79	No	Yes	0	6	7
12	R:R:Q355	R:R:Q383	18.8521	7.68	Yes	Yes	9	8	9
13	R:R:Q383	R:R:Y191	21.3815	11.27	Yes	Yes	0	9	8
14	R:R:N233	R:R:Y191	42.8319	17.44	No	Yes	0	9	8
15	R:R:N194	R:R:N233	46.7361	8.17	No	No	0	8	9
16	R:R:H377	R:R:H381	91.9027	9.55	Yes	No	0	7	9
17	R:R:H156	R:R:H381	92.2993	9.55	Yes	No	0	7	9
18	R:R:H156	R:R:I198	93.2485	11.93	Yes	No	0	7	7
19	R:R:H226	R:R:I198	93.6112	3.98	Yes	No	0	6	7
20	L:L:L12	R:R:H377	86.9866	3.86	No	Yes	11	0	7
21	L:L:L12	L:L:L16	89.0892	6.92	No	No	0	0	0
22	L:L:F15	L:L:L16	86.902	3.65	No	No	0	0	0
23	L:L:F15	R:R:F137	86.3893	6.43	No	No	0	0	1
24	R:R:D101	R:R:F137	85.6022	5.97	No	No	0	4	1
25	L:L:T30	R:R:D101	85.335	7.23	No	No	0	0	4
26	L:L:G33	R:R:W128	12.375	5.63	No	Yes	0	0	5
27	L:L:?38	R:R:W128	13.1259	8.46	Yes	Yes	0	0	5
28	L:L:?38	R:R:Y131	15.0169	11.61	Yes	Yes	1	0	5
29	R:R:V108	R:R:Y131	24.4127	11.36	No	Yes	0	7	5
30	R:R:E106	R:R:V108	44.6274	2.85	Yes	No	0	4	7
31	R:R:C95	R:R:E106	33.9197	3.04	Yes	Yes	3	9	4
32	R:R:C95	R:R:F102	35.4831	2.79	Yes	Yes	3	9	4
33	L:L:T30	R:R:F102	85.0448	2.59	No	Yes	0	0	4
34	R:R:N130	R:R:W128	12.9941	6.78	No	Yes	0	8	5
35	R:R:N130	R:R:T132	13.9625	4.39	No	No	0	8	6
36	R:R:M133	R:R:T132	15.9406	3.01	No	No	0	5	6
37	R:R:E106	R:R:M133	16.9635	6.77	Yes	No	0	4	5
38	R:R:C134	R:R:E106	33.1411	10.64	No	Yes	3	9	4
39	R:R:C134	R:R:F102	33.5776	2.79	No	Yes	3	9	4
40	L:L:G33	L:L:N31	10.3184	3.39	No	No	0	0	0
41	R:R:F102	R:R:F99	16.2513	8.57	Yes	No	0	4	5
42	R:R:F99	R:R:Y98	15.2043	4.13	No	Yes	0	5	4
43	R:R:A51	R:R:Y98	15.1753	2.67	No	Yes	0	8	4
44	R:R:A51	R:R:K54	14.6287	3.21	No	No	0	8	4
45	R:R:K54	R:R:R58	13.514	2.48	No	Yes	0	4	3
46	R:R:V108	R:R:W82	20.1011	3.68	No	Yes	0	7	9
47	R:R:W118	R:R:W82	10.2881	12.18	Yes	Yes	1	9	9
48	R:R:H121	R:R:W128	12.375	24.33	Yes	Yes	0	4	5
49	R:R:Q355	R:R:V349	19.9113	4.3	Yes	No	0	8	8
50	R:R:M187	R:R:Y191	31.8643	4.79	No	Yes	0	8	8
51	R:R:E240	R:R:M187	31.452	6.77	No	No	0	9	8
52	R:R:E240	R:R:H184	27.6301	11.08	No	Yes	0	9	9
53	R:R:F188	R:R:H184	24.2748	5.66	Yes	Yes	0	8	9
54	R:R:F188	R:R:S166	11.3388	3.96	Yes	No	0	8	9
55	R:R:C392	R:R:F170	10.7053	5.59	Yes	No	0	9	8
56	R:R:L193	R:R:M229	25.3376	5.65	No	Yes	0	6	4
57	R:R:L189	R:R:L193	24.5977	4.15	No	No	0	3	6
58	R:R:L189	R:R:W267	24.3232	3.42	No	No	0	3	9
59	R:R:W236	R:R:W267	21.9981	14.06	Yes	No	0	9	9
60	R:R:L183	R:R:W236	20.3054	3.42	Yes	Yes	0	8	9
61	R:R:C392	R:R:I169	14.2068	1.64	Yes	No	0	9	8
62	R:R:F173	R:R:I169	13.2057	2.51	Yes	No	0	7	8
63	R:R:H277	R:R:R281	15.0217	13.54	No	Yes	0	7	7
64	R:R:C232	R:R:Y228	10.01	5.38	Yes	Yes	5	8	8
65	R:R:V305	R:R:Y234	11.1683	5.05	No	Yes	0	7	7
66	R:R:F235	R:R:V305	10.692	3.93	Yes	No	0	5	7
67	R:R:I354	R:R:V349	12.6084	6.14	No	No	0	6	8
68	R:R:M376	R:R:Y372	13.9638	2.39	Yes	No	0	7	7
69	R:R:H201	R:R:H226	10.646	4.78	Yes	Yes	7	6	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:K1	R:R:V293	4.55	0	No	No	0	6	0	1
L:L:K1	R:R:E294	4.05	0	No	No	0	3	0	1
L:L:C2	R:R:Y299	4.03	6	Yes	No	0	7	0	1
L:L:N3	R:R:W361	11.3	0	No	No	0	4	0	1
L:L:T4	R:R:M306	3.01	6	Yes	No	0	4	0	1
L:L:A5	R:R:M376	3.22	0	No	Yes	0	7	0	1
L:L:T6	R:R:H302	10.95	0	No	No	0	6	0	1
L:L:C7	R:R:H302	7.37	6	Yes	No	0	6	0	1
L:L:A8	R:R:H377	4.39	0	No	Yes	0	7	0	1
L:L:T9	R:R:I198	3.04	0	No	No	0	7	0	1
L:L:Q10	R:R:H223	4.95	0	No	Yes	0	5	0	1
L:L:L12	R:R:L148	2.77	11	No	No	0	5	0	1
L:L:L12	R:R:H377	3.86	11	No	Yes	0	7	0	1
L:L:E14	R:R:V293	4.28	0	No	No	0	6	0	1
L:L:F15	R:R:F137	6.43	0	No	No	0	1	0	1
L:L:F15	R:R:A145	2.77	0	No	No	0	4	0	1
L:L:L16	R:R:Y149	3.52	0	No	Yes	0	5	0	1
L:L:R17	R:R:L291	8.5	0	No	No	0	6	0	1
L:L:S19	R:R:F137	14.53	0	No	No	0	1	0	1
L:L:S19	R:R:L142	6.01	0	No	No	0	2	0	1
L:L:T30	R:R:D101	7.23	0	No	No	0	4	0	1
L:L:V32	R:R:T132	4.76	0	No	No	0	6	0	1
L:L:G33	R:R:W128	5.63	0	No	Yes	0	5	0	1
L:L:P37	R:R:D77	4.83	1	Yes	Yes	0	9	0	1
L:L:P37	R:R:G78	4.06	1	Yes	No	0	5	0	1
L:L:P37	R:R:W79	9.46	1	Yes	Yes	0	6	0	1
L:L:?38	R:R:D77	10.08	1	Yes	Yes	0	9	0	1
L:L:?38	R:R:W128	8.46	1	Yes	Yes	0	5	0	1
L:L:?38	R:R:S129	7.43	1	Yes	Yes	0	7	0	1
L:L:?38	R:R:Y131	11.61	1	Yes	Yes	0	5	0	1
R:R:M48	R:R:W79	4.65	0	No	Yes	6	6	2	1
R:R:D77	R:R:G78	5.03	1	Yes	No	9	5	1	1
R:R:D77	R:R:S129	5.89	1	Yes	Yes	9	7	1	1
R:R:D77	R:R:Y131	9.2	1	Yes	Yes	9	5	1	1
R:R:G78	R:R:W79	4.22	1	No	Yes	5	6	1	1
R:R:W79	R:R:Y131	7.72	1	Yes	Yes	6	5	1	1
R:R:C95	R:R:F102	2.79	3	Yes	Yes	9	4	2	1
R:R:C134	R:R:C95	5.46	3	No	Yes	9	9	2	2
R:R:F102	R:R:F99	8.57	3	Yes	No	4	5	1	2
R:R:D101	R:R:F137	5.97	0	No	No	4	1	1	1
R:R:C134	R:R:F102	2.79	3	No	Yes	9	4	2	1
R:R:V108	R:R:Y131	11.36	0	No	Yes	7	5	2	1
R:R:F119	R:R:K110	6.2	0	No	Yes	4	8	2	2
R:R:K110	R:R:S129	4.59	1	Yes	Yes	8	7	2	1
R:R:F119	R:R:W128	3.01	0	No	Yes	4	5	2	1
R:R:H121	R:R:W128	24.33	0	Yes	Yes	4	5	2	1
R:R:N130	R:R:W128	6.78	0	No	Yes	8	5	2	1
R:R:S129	R:R:Y131	12.72	1	Yes	Yes	7	5	1	1
R:R:N130	R:R:T132	4.39	0	No	No	8	6	2	1
R:R:M133	R:R:T132	3.01	0	No	No	5	6	2	1
R:R:H377	R:R:L148	7.71	11	Yes	No	7	5	1	1
R:R:Y149	R:R:Y150	10.92	0	Yes	No	5	4	1	2
R:R:I153	R:R:Y149	6.04	0	No	Yes	7	5	2	1
R:R:L202	R:R:Y149	3.52	0	No	Yes	7	5	2	1
R:R:H156	R:R:I198	11.93	0	Yes	No	7	7	2	1
R:R:H156	R:R:H381	9.55	0	Yes	No	7	9	2	2
R:R:H226	R:R:I198	3.98	7	Yes	No	6	7	2	1
R:R:H201	R:R:V206	2.77	7	Yes	No	6	3	2	1
R:R:H201	R:R:H223	3.58	7	Yes	Yes	6	5	2	1
R:R:H201	R:R:H226	4.78	7	Yes	Yes	6	6	2	2
R:R:H201	R:R:L291	7.71	7	Yes	No	6	6	2	1
R:R:P207	R:R:V206	3.53	0	No	No	3	3	2	1
R:R:C289	R:R:V212	6.83	0	No	No	9	3	2	1
R:R:H223	R:R:H226	7.17	7	Yes	Yes	5	6	1	2
R:R:H223	R:R:Q227	9.89	7	Yes	No	5	7	1	2
R:R:H223	R:R:L291	7.71	7	Yes	No	5	6	1	1
R:R:H302	R:R:M230	5.25	0	No	No	6	6	1	2
R:R:E294	R:R:S292	2.87	0	No	No	3	4	1	2
R:R:L298	R:R:V293	2.98	0	No	No	6	6	2	1
R:R:M376	R:R:Q355	4.08	0	Yes	Yes	7	8	1	2
R:R:F359	R:R:M376	4.98	0	No	Yes	6	7	2	1
R:R:I380	R:R:M376	5.83	0	No	Yes	6	7	2	1
R:R:H377	R:R:H381	9.55	11	Yes	No	7	9	1	2
L:L:R17	R:R:V212	2.62	0	No	No	0	3	0	1
L:L:T30	R:R:F102	2.59	0	No	Yes	0	4	0	1
R:R:M376	R:R:Y372	2.39	0	Yes	No	7	7	1	2
R:R:L148	R:R:Y374	2.34	11	No	Yes	5	6	1	2
L:L:A13	R:R:V206	1.7	0	No	No	0	3	0	1
L:L:P28	R:R:Y41	1.39	0	No	No	0	3	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9BUE_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.77
Number of Linked Nodes	369
Number of Links	430
Number of Hubs	67
Number of Links mediated by Hubs	238
Number of Communities	14
Number of Nodes involved in Communities	71
Number of Links involved in Communities	95

Path Summary
Number Of Nodes in MetaPath	70
Number Of Links MetaPath	69
Number of Shortest Paths	136494
Length Of Smallest Path	3
Average Path Length	20.3762
Length of Longest Path	41
Minimum Path Strength	1.245
Average Path Strength	6.13425
Maximum Path Strength	16.395
Minimum Path Correlation	0.7
Average Path Correlation	0.959808
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.22581
Average % Of Corr. Nodes	51.394
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	40.7906
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• amide binding • amyloid-beta binding • binding • peptide binding • calcitonin family receptor activity • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • calcitonin receptor activity • amylin receptor activity • calcitonin gene-related peptide receptor activity • calcitonin binding • calcitonin family binding • peptide hormone binding • hormone binding • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • cellular response to stimulus • positive regulation of cell communication • regulation of cellular process • positive regulation of signal transduction • response to stimulus • signaling • positive regulation of biological process • regulation of signal transduction • intracellular signal transduction • cell communication • positive regulation of response to stimulus
Gene Ontology	Biological Process	• positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • cellular response to stimulus • positive regulation of cell communication • regulation of cellular process • positive regulation of signal transduction • response to stimulus • signaling • positive regulation of biological process • regulation of signal transduction • intracellular signal transduction • cell communication • positive regulation of response to stimulus • regulation of intracellular signal transduction • intracellular signaling cassette • regulation of calcium-mediated signaling • positive regulation of calcium-mediated signaling • signal transduction • positive regulation of cellular process • regulation of biological process • regulation of signaling • positive regulation of intracellular signal transduction • regulation of response to stimulus • calcium-mediated signaling • regulation of cell communication • cellular process • positive regulation of signaling • catabolic process • negative regulation of biological process • RNA metabolic process • macromolecule catabolic process • regulation of primary metabolic process • nucleobase-containing compound metabolic process • post-transcriptional regulation of gene expression • regulation of RNA metabolic process • regulation of mRNA catabolic process • negative regulation of cellular process • regulation of nucleobase-containing compound metabolic process • RNA catabolic process • negative regulation of macromolecule metabolic process • regulation of biosynthetic process • mRNA catabolic process • negative regulation of metabolic process • primary metabolic process • regulation of macromolecule metabolic process • regulation of catabolic process • gene expression • mRNA metabolic process • macromolecule biosynthetic process • nucleic acid metabolic process • nucleobase-containing compound catabolic process • regulation of mRNA stability • regulation of gene expression • negative regulation of gene expression • biosynthetic process • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • regulation of RNA stability • nucleic acid catabolic process • metabolic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • regulation of mRNA metabolic process • regulation of metabolic process • positive regulation of ERK1 and ERK2 cascade • positive regulation of MAPK cascade • regulation of MAPK cascade • MAPK cascade • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of macromolecule biosynthetic process • positive regulation of metabolic process • positive regulation of gene expression • positive regulation of biosynthetic process • positive regulation of macromolecule metabolic process • amylin receptor 1 signaling pathway • amylin receptor signaling pathway • calcitonin family receptor signaling pathway • G protein-coupled receptor signaling pathway • regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • phosphatidylinositol 3-kinase/protein kinase B signal transduction • response to corticosteroid • response to lipid • response to hormone • response to steroid hormone • response to chemical • response to endogenous stimulus • response to glucocorticoid • adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • response to amyloid-beta • cell surface receptor signaling pathway • calcitonin gene-related peptide receptor signaling pathway • multicellular organismal process • ossification • amylin receptor 2 signaling pathway • developmental process • myeloid leukocyte differentiation • cellular developmental process • hemopoiesis • cell development • myeloid cell differentiation • cell differentiation • osteoclast differentiation • anatomical structure development • leukocyte differentiation • positive regulation of cAMP/PKA signal transduction • cAMP/PKA signal transduction • regulation of cAMP/PKA signal transduction • regulation of multicellular organismal process • negative regulation of multicellular organismal process • regulation of ossification • negative regulation of ossification • amylin receptor 3 signaling pathway • membrane-bounded organelle • cell projection • cellular anatomical structure • organelle • cilium • plasma membrane bounded cell projection • cell periphery • plasma membrane • membrane • protein-containing complex • amylin receptor complex • plasma membrane protein complex • amylin receptor complex 3 • membrane protein complex
Gene Ontology	Cellular Component	• membrane-bounded organelle • cell projection • cellular anatomical structure • organelle • cilium • plasma membrane bounded cell projection • cell periphery • plasma membrane • membrane • protein-containing complex • amylin receptor complex • plasma membrane protein complex • amylin receptor complex 3 • membrane protein complex • receptor complex • plasma membrane signaling receptor complex • G protein-coupled receptor complex • calcitonin family receptor complex • amylin receptor complex 2 • amylin receptor complex 1 • axon • neuron projection • acrosomal vesicle • intracellular anatomical structure • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle • secretory granule • secretory vesicle • cytoplasm • vesicle • protein binding • binding • signaling receptor binding • amide binding • amyloid-beta binding • peptide binding • molecular function activator activity • molecular function regulator activity • signaling receptor regulator activity • receptor ligand activity • signaling receptor activator activity • hormone activity • lipid binding • identical protein binding • cellular response to stimulus • positive regulation of cell communication • regulation of cellular process • positive regulation of signal transduction • response to stimulus • signaling • positive regulation of biological process • regulation of signal transduction • intracellular signal transduction • cell communication • positive regulation of response to stimulus • regulation of intracellular signal transduction • intracellular signaling cassette • regulation of calcium-mediated signaling • positive regulation of calcium-mediated signaling • signal transduction • positive regulation of cellular process • regulation of biological process • regulation of signaling • biological regulation • positive regulation of intracellular signal transduction • regulation of response to stimulus • calcium-mediated signaling • regulation of cell communication • cellular process • positive regulation of signaling • apoptotic process • cell death • programmed cell death • positive regulation of programmed cell death • regulation of apoptotic process • regulation of programmed cell death • positive regulation of apoptotic process • behavior • multicellular organismal process • eating behavior • feeding behavior • cell-cell signaling • amylin receptor 1 signaling pathway • amylin receptor signaling pathway • calcitonin family receptor signaling pathway • G protein-coupled receptor signaling pathway • regulation of cellular component organization • negative regulation of cellular component organization • protein-containing complex organization • negative regulation of biological process • regulation of cellular component biogenesis • negative regulation of protein-containing complex assembly • cellular component organization • cellular component biogenesis • regulation of protein-containing complex assembly • cellular component assembly • protein-containing complex assembly • negative regulation of cellular process • cellular component organization or biogenesis • myeloid leukocyte differentiation • regulation of leukocyte differentiation • cellular developmental process • regulation of developmental process • cell development • regulation of cell differentiation • regulation of cell development • regulation of osteoclast differentiation • multicellular organism development • cell differentiation • osteoclast differentiation • anatomical structure development • regulation of immune system process • regulation of multicellular organismal process • negative regulation of cell differentiation • negative regulation of hemopoiesis • developmental process • regulation of multicellular organismal development • negative regulation of leukocyte differentiation • hemopoiesis • regulation of myeloid cell differentiation • negative regulation of developmental process • regulation of myeloid leukocyte differentiation • negative regulation of myeloid cell differentiation • negative regulation of osteoclast differentiation • negative regulation of myeloid leukocyte differentiation • negative regulation of cell development • myeloid cell differentiation • negative regulation of immune system process • immune system process • regulation of hemopoiesis • negative regulation of multicellular organismal process • leukocyte differentiation • positive regulation of MAPK cascade • regulation of MAPK cascade • MAPK cascade • negative regulation of tissue remodeling • homeostatic process • negative regulation of bone remodeling • regulation of bone remodeling • tissue homeostasis • regulation of tissue remodeling • regulation of bone resorption • bone resorption • negative regulation of bone resorption • multicellular organismal-level homeostasis • tissue remodeling • bone remodeling • anatomical structure homeostasis • amylin receptor 2 signaling pathway • system process • sensory perception • nervous system process • sensory perception of pain • positive regulation of cAMP/PKA signal transduction • cAMP/PKA signal transduction • regulation of cAMP/PKA signal transduction • negative regulation of amyloid fibril formation • regulation of amyloid fibril formation • amyloid fibril formation • regulation of primary metabolic process • negative regulation of supramolecular fiber organization • protein metabolic process • negative regulation of protein metabolic process • negative regulation of macromolecule metabolic process • regulation of protein metabolic process • negative regulation of metabolic process • primary metabolic process • regulation of macromolecule metabolic process • regulation of supramolecular fiber organization • metabolic process • macromolecule metabolic process • supramolecular fiber organization • regulation of metabolic process • amylin receptor 3 signaling pathway • extracellular region • somatodendritic compartment • cell body • neuronal cell body • extracellular space • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • extrinsic component of plasma membrane • catalytic complex • cytoplasmic side of membrane • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular membrane-bounded organelle • synapse • cell junction • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception of taste • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • organelle membrane • cytosol • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • G protein-coupled receptor binding • dopamine receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • sensory perception of smell • response to peptide hormone • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • skeletal system development • bone development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • adaptive thermogenesis • positive regulation of metabolic process • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • localization • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • regulation of protein transport • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • inflammatory response to antigenic stimulus • regulation of response to stress • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • trans-Golgi network
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	NH2
PDB Residues	L:L:?38
Environment Details	Open EMBL-EBI Page
Code	NH2
Name	AMINO GROUP
Synonyms
Identifier
Formula	H2 N
Molecular Weight	16.023
SMILES
PubChem	123329
Formal Charge	0
Total Atoms	3
Total Chiral Atoms	0
Total Bonds	2
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P30988
Sequence	>9BUE_nogp_Chain_R P F L Y V V G R K K M M D A Q Y K C Y D R M Q Q L P P Y C N R T W D G W L C W D D T P A G V L S Y Q F C P D Y F P D F D P S E K V T K Y C D W F K H P E N N R T W S N Y T M C N A F T P E K L K N A Y V L Y Y L A I V G H S L S I F T L V I S L G I F V F F R S L G C Q R V T L H K N M F L T Y I L N S M I I I I H L V E V V P N G E L V R R D P V S C K I L H F F H Q Y M M A C N Y F W M L C E G I Y L H T L I V V A V F T E K Q R L R W Y Y L L G W G F P L V P T T I H A I T R A V Y F N D N C W L S V E T H L L Y I I H G P V M A A L V V N F F F L L N I V R V L V T K M R E T H E A E S H M Y L K A V K A T M I L V P L L G I Q F V V F P W R P S N K M L G K I Y D Y V M H S L I H F Q G F F V A T I Y C F C N N E V Q T T V K R Q W A Q F K I Q W Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7X5H	A	Amine	5-Hydroxytryptamine	5-HT_5A	Homo sapiens	5-CT	-	Gi1/β1/γ2	3.1	2022-09-14	doi.org/10.1038/s41421-022-00412-3
	7X5H (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_5A	Homo sapiens	5-CT	-		3.1	2022-09-14	doi.org/10.1038/s41421-022-00412-3
	7UM5	A	Amine	5-Hydroxytryptamine	5-HT_5A	Homo sapiens	5-CT	-	chim(NtGi1-Go)/β1/γ2	2.73	2022-07-20	doi.org/10.1038/s41594-022-00796-6
	7UM5 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_5A	Homo sapiens	5-CT	-		2.73	2022-07-20	doi.org/10.1038/s41594-022-00796-6
	7XTC	A	Amine	5-Hydroxytryptamine	5-HT₇	Homo sapiens	5-CT	-	Gs/β1/γ2	3.2	2022-07-27	doi.org/10.1016/j.molcel.2022.05.031
	7XTC (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT₇	Homo sapiens	5-CT	-		3.2	2022-07-27	doi.org/10.1016/j.molcel.2022.05.031
	6E67	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	-	Gs(CT)	3.7	2019-06-05	doi.org/10.1016/j.cell.2019.04.021
	6NIY	B1	Peptide	Calcitonin	CT	Homo sapiens	Adrenomedullin	-	Gs/β1/γ2	3.34	2019-01-23	doi.org/10.1021/acsptsci.8b00056
	6NIY (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	Adrenomedullin	-		3.34	2019-01-23	doi.org/10.1021/acsptsci.8b00056
	5UZ7	B1	Peptide	Calcitonin	CT	Homo sapiens	-	-	Gs/β1/γ2	4.1	2017-05-03	doi.org/10.1038/nature22327
	5UZ7 (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	-	-		4.1	2017-05-03	doi.org/10.1038/nature22327
	8F0J	B1	Peptide	Calcitonin	CT	Homo sapiens	Pramlintide Analogue San45	-	Gs/β1/γ2	2	2023-08-02	doi.org/10.1038/s41589-023-01393-4
	8F0J (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	Pramlintide Analogue San45	-		2	2023-08-02	doi.org/10.1038/s41589-023-01393-4
	7TYL	B1	Peptide	Calcitonin	CT	Homo sapiens	Amylin	-	Gs/β1/γ2	3.3	2022-03-23	doi.org/10.1126/science.abm9609
	7TYL (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	Amylin	-		3.3	2022-03-23	doi.org/10.1126/science.abm9609
	7TYO	B1	Peptide	Calcitonin	CT	Homo sapiens	Calcitonin	-	Gs/β1/γ2	2.7	2022-03-23	doi.org/10.1126/science.abm9609
	7TYO (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	Calcitonin	-		2.7	2022-03-23	doi.org/10.1126/science.abm9609
	7TYI	B1	Peptide	Calcitonin	CT	Homo sapiens	Amylin	-	Gs/β1/γ2	3.3	2022-03-30	doi.org/10.1126/science.abm9609
	7TYI (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	Amylin	-		3.3	2022-03-30	doi.org/10.1126/science.abm9609
	7TYN	B1	Peptide	Calcitonin	CT	Homo sapiens	Calcitonin-1	-	Gs/β1/γ2	2.6	2022-03-30	doi.org/10.1126/science.abm9609
	7TYN (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	Calcitonin-1	-		2.6	2022-03-30	doi.org/10.1126/science.abm9609
	9BUB	B1	Peptide	Calcitonin	CT	Homo sapiens	Cagrilintide	-	Gs/β1/γ2	2.3	2025-04-23	doi.org/10.1038/s41467-025-58680-y
	9BUB (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	Cagrilintide	-		2.3	2025-04-23	doi.org/10.1038/s41467-025-58680-y
	9BLB	B1	Peptide	Calcitonin	CT	Homo sapiens	Cagrilintide backbone (non-acylated)	-	Gs/β1/γ2	3.2	2025-04-16	To be published
	9BLB (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	Cagrilintide backbone (non-acylated)	-		3.2	2025-04-16	To be published
	9BLC	B1	Peptide	Calcitonin	CT	Homo sapiens	Cagrilintide backbone (non-acylated)	-	Gs/β1/γ2	3.3	2025-04-16	To be published
	9BLC (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	Cagrilintide backbone (non-acylated)	-		3.3	2025-04-16	To be published
	9BUE	B1	Peptide	Calcitonin	CT	Homo sapiens	Cagrilintide	-	Gs/β1/γ2	3.6	2025-04-16	To be published
	9BUE (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	Cagrilintide	-		3.6	2025-04-16	To be published
	9BUC	B1	Peptide	Calcitonin	CT	Homo sapiens	Cagrilintide	-	Gs/β1/γ2	3.4	2025-04-23	To be published
	9BUC (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	Cagrilintide	-		3.4	2025-04-23	To be published
	9BUD	B1	Peptide	Calcitonin	CT	Homo sapiens	Cagrilintide	-	Gs/β1/γ2	2.5	2025-04-23	To be published
	9BUD (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	Cagrilintide	-		2.5	2025-04-23	To be published
	9AUC	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Calcitonin gene-related peptide-1	-	Gs/β1/γ2; RAMP1	2.4	2024-04-24	doi.org/10.1021/acs.biochem.4c00114
	9AUC (No Gprot)	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Calcitonin gene-related peptide-1	-		2.4	2024-04-24	doi.org/10.1021/acs.biochem.4c00114
	7TYF	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Amylin	-	Gs/β1/γ2; RAMP1	2.2	2022-03-23	doi.org/10.1126/science.abm9609
	7TYF (No Gprot)	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Amylin	-		2.2	2022-03-23	doi.org/10.1126/science.abm9609
	7TYW	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Calcitonin-1	-	Gs/β1/γ2; RAMP1	3	2022-03-23	doi.org/10.1126/science.abm9609
	7TYW (No Gprot)	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Calcitonin-1	-		3	2022-03-23	doi.org/10.1126/science.abm9609
	9BLW	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Cagrilintide backbone (non-acylated)	-	Gs/β1/γ2; RAMP1	3.2	2025-04-16	To be published
	9BLW (No Gprot)	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Cagrilintide backbone (non-acylated)	-		3.2	2025-04-16	To be published
	9BP3	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Cagrilintide	-	Gs/β1/γ2; RAMP1	2.2	2025-04-23	To be published
	9BP3 (No Gprot)	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Cagrilintide	-		2.2	2025-04-23	To be published
	7TYH	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Calcitonin-1	-	Gs/β1/γ2; RAMP2	3.3	2022-03-23	doi.org/10.1126/science.abm9609
	7TYH (No Gprot)	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Calcitonin-1	-		3.3	2022-03-23	doi.org/10.1126/science.abm9609
	7TYY	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Calcitonin-1	-	Gs/β1/γ2; RAMP2	3	2022-03-23	doi.org/10.1126/science.abm9609
	7TYY (No Gprot)	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Calcitonin-1	-		3	2022-03-23	doi.org/10.1126/science.abm9609
	7TYX	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Amylin	-	Gs/β1/γ2; RAMP2	2.55	2022-03-30	doi.org/10.1126/science.abm9609
	7TYX (No Gprot)	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Amylin	-		2.55	2022-03-30	doi.org/10.1126/science.abm9609
	9BQ3	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Cagrilintide	-	Gs/β1/γ2; RAMP2	2.8	2025-04-23	To be published
	9BQ3 (No Gprot)	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Cagrilintide	-		2.8	2025-04-23	To be published
	8F0K	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Pramlintide Analogue San385	-	Gs/β1/γ2; RAMP3	1.9	2023-08-02	doi.org/10.1038/s41589-023-01393-4
	8F0K (No Gprot)	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Pramlintide Analogue San385	-		1.9	2023-08-02	doi.org/10.1038/s41589-023-01393-4
	8F2A	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Pramlintide Analogue San385	-	Gs/β1/γ2; RAMP3	2.2	2023-08-02	doi.org/10.1038/s41589-023-01393-4
	8F2A (No Gprot)	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Pramlintide Analogue San385	-		2.2	2023-08-02	doi.org/10.1038/s41589-023-01393-4
	8F2B	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Pramlintide Analogue San45	-	Gs/β1/γ2; RAMP3	2	2023-08-02	doi.org/10.1038/s41589-023-01393-4
	8F2B (No Gprot)	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Pramlintide Analogue San45	-		2	2023-08-02	doi.org/10.1038/s41589-023-01393-4
	7TZF	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Amylin	-	Gs/β1/γ2; RAMP3	2.4	2022-03-23	doi.org/10.1126/science.abm9609
	7TZF (No Gprot)	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Amylin	-		2.4	2022-03-23	doi.org/10.1126/science.abm9609
	9BTW	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Cagrilintide	-	Gs/β1/γ2; RAMP3	3	2025-04-16	To be published
	9BTW (No Gprot)	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Cagrilintide	-		3	2025-04-16	To be published
	6E3Y	B1	Peptide	Calcitonin	CT Like	Homo sapiens	Calcitonin gene-related peptide-1	-	Gs/β1/γ2; RAMP1	3.3	2018-09-19	doi.org/10.1038/s41586-018-0535-y
	6E3Y (No Gprot)	B1	Peptide	Calcitonin	CT Like	Homo sapiens	Calcitonin gene-related peptide-1	-		3.3	2018-09-19	doi.org/10.1038/s41586-018-0535-y
	7KNT	B1	Peptide	Calcitonin	CT Like	Homo sapiens	-	-	RAMP1	3.15	2021-02-24	doi.org/10.1126/science.abf7258
	7KNU	B1	Peptide	Calcitonin	CT Like	Homo sapiens	Calcitonin gene-related peptide-1	-	RAMP1	3.49	2021-02-24	doi.org/10.1126/science.abf7258
	6UUN	B1	Peptide	Calcitonin	CT Like (AM1)	Homo sapiens	Adrenomedullin	-	Gs/β1/γ2; RAMP2	3	2020-03-25	doi.org/10.1021/acsptsci.9b00080
	6UUN (No Gprot)	B1	Peptide	Calcitonin	CT Like (AM1)	Homo sapiens	Adrenomedullin	-		3	2020-03-25	doi.org/10.1021/acsptsci.9b00080
	6UUS	B1	Peptide	Calcitonin	CT Like (AM2)	Homo sapiens	Adrenomedullin	-	Gs/β1/γ2; RAMP3	2.4	2020-04-01	doi.org/10.1021/acsptsci.9b00080
	6UUS (No Gprot)	B1	Peptide	Calcitonin	CT Like (AM2)	Homo sapiens	Adrenomedullin	-		2.4	2020-04-01	doi.org/10.1021/acsptsci.9b00080
	6UVA	B1	Peptide	Calcitonin	CT Like (AM2)	Homo sapiens	Adrenomedullin-2	-	Gs/β1/γ2; RAMP3	2.3	2020-04-01	doi.org/10.1021/acsptsci.9b00080
	6UVA (No Gprot)	B1	Peptide	Calcitonin	CT Like (AM2)	Homo sapiens	Adrenomedullin-2	-		2.3	2020-04-01	doi.org/10.1021/acsptsci.9b00080
	6PH7	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	Nerol	Gt(CT)	2.9	2020-07-01	To be published
	6PGS	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	Geraniol	Gt(CT)	2.9	2020-07-01	To be published
	6PEL	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	Citronellol	Gt(CT)	3.19	2020-06-24	To be published
	4J4Q	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl β-D-Glucopyranoside	-	Gt(CT)	2.65	2013-10-30	doi.org/10.1002/anie.201302374
	4X1H	A	Sensory	Opsins	Rhodopsin	Bos taurus	Nonyl-β-D-Glucopyranoside	-	Gt(CT)	2.29	2015-11-04	doi.org/10.1016/j.str.2015.09.015
	4BEY	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	Gt(CT)	2.9	2013-05-08	doi.org/10.1038/embor.2013.44
	3DQB	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	Gt(CT)	3.2	2008-09-23	doi.org/10.1038/nature07330
	3PQR	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gt(CT)	2.85	2011-03-09	doi.org/10.1038/nature09789
	2X72	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gt(CT)	3	2011-03-16	doi.org/10.1038/nature09795
	5WKT	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl-β-D-Glucopyranoside	-	Gt(CT)	3.2	2017-12-13	doi.org/10.1038/nprot.2017.135
	4A4M	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gt(CT)	3.3	2012-01-25	doi.org/10.1073/pnas.1114089108
	5EN0	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gt(CT)	2.81	2016-08-10	doi.org/10.15252/embr.201642671
	6NWE	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl-β-D-Glucopyranoside	-	Gt(CT)	2.71	2020-02-12	To be published
	6TP4	A	Peptide	Orexin	OX₁	Homo sapiens	ACT-462206	-	-	3.01	2020-01-01	doi.org/10.1021/acs.jmedchem.9b01787

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