psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	E:E:N60	E:E:Y61	12.79	No	No	9	3	8
2	E:E:F107	E:E:N60	4.83	Yes	No	9	5	3
3	E:E:E62	E:E:Y61	13.47	No	No	0	3	8
4	E:E:F107	E:E:Y61	8.25	Yes	No	9	5	8
5	E:E:A64	E:E:F103	8.32	No	Yes	0	3	1
6	E:E:F103	E:E:V65	5.24	Yes	No	0	1	5
7	E:E:L115	E:E:V65	5.96	No	No	0	4	5
8	E:E:F67	E:E:N70	2.42	No	No	0	1	2
9	E:E:C68	E:E:C99	7.28	No	No	0	9	9
10	E:E:W69	E:E:Y72	3.86	No	Yes	3	6	9
11	E:E:E122	E:E:W69	3.27	No	No	0	4	6
12	E:E:T123	E:E:W69	4.85	No	No	3	8	6
13	E:E:H71	E:E:Q75	12.36	No	No	0	1	3
14	E:E:M76	E:E:Y72	9.58	Yes	Yes	3	9	9
15	E:E:P92	E:E:Y72	2.78	No	Yes	0	6	9
16	E:E:L96	E:E:Y72	22.27	No	Yes	0	8	9
17	E:E:T123	E:E:Y72	7.49	No	Yes	3	8	9
18	E:E:H127	E:E:Y72	4.36	Yes	Yes	3	8	9
19	E:E:K73	E:E:M76	5.76	No	Yes	0	5	9
20	E:E:I79	E:E:M76	2.92	No	Yes	0	7	9
21	E:E:H127	E:E:M76	9.19	Yes	Yes	3	8	9
22	E:E:D77	E:E:P78	6.44	No	No	0	4	5
23	E:E:I79	E:E:I89	11.77	No	Yes	0	7	8
24	E:E:D82	E:E:D85	3.99	No	No	0	6	7
25	E:E:C84	E:E:W83	6.53	No	No	0	9	7
26	E:E:N130	E:E:W83	11.3	No	No	0	9	7
27	E:E:C84	E:E:F128	5.59	No	Yes	3	9	9
28	E:E:C131	E:E:C84	7.28	No	No	3	9	9
29	E:E:A87	E:E:D85	4.63	No	No	0	5	7
30	E:E:I89	E:E:W86	5.87	Yes	Yes	0	8	9
31	E:E:S90	E:E:W86	9.88	No	Yes	3	7	9
32	E:E:W86	E:E:Y93	8.68	Yes	Yes	3	9	9
33	E:E:W86	R:R:M42	10.47	Yes	Yes	3	9	3
34	E:E:W86	R:R:T43	9.7	Yes	No	0	9	5
35	E:E:W86	R:R:Y46	21.22	Yes	No	3	9	2
36	E:E:I89	E:E:P92	3.39	Yes	No	0	8	6
37	E:E:H127	E:E:I89	3.98	Yes	Yes	0	8	8
38	E:E:S90	R:R:M42	4.6	No	Yes	3	7	3
39	E:E:P92	E:E:R91	4.32	No	No	0	6	6
40	E:E:I120	E:E:Y93	2.42	No	Yes	0	9	9
41	E:E:Y93	R:R:Q45	7.89	Yes	Yes	0	9	5
42	E:E:Y93	R:R:Y46	32.76	Yes	No	3	9	2
43	E:E:S94	R:R:R38	5.27	No	No	3	8	5
44	E:E:S94	R:R:M42	6.13	No	Yes	3	8	3
45	E:E:R97	R:R:I41	8.77	No	Yes	0	7	6
46	E:E:D98	E:E:H102	6.3	No	Yes	0	1	1
47	E:E:C99	E:E:F103	4.19	No	Yes	0	9	1
48	E:E:F111	E:E:L100	2.44	No	No	0	8	8
49	E:E:I119	E:E:L100	2.85	No	No	0	5	8
50	E:E:E101	E:E:H102	6.15	No	Yes	10	8	1
51	E:E:E101	E:E:E105	8.88	No	No	10	8	5
52	E:E:F103	E:E:H102	2.26	Yes	Yes	0	1	1
53	E:E:E105	E:E:H102	2.46	No	Yes	10	5	1
54	E:E:A104	E:E:F111	8.32	No	No	0	9	8
55	E:E:E105	E:E:L106	3.98	No	No	0	5	1
56	E:E:L109	E:E:N113	4.12	No	No	0	7	9
57	E:E:G110	E:E:N113	5.09	No	No	0	5	9
58	E:E:G110	R:R:R119	4.5	No	Yes	0	5	4
59	E:E:P112	R:R:T68	8.74	No	Yes	1	9	5
60	E:E:P112	R:R:W111	8.11	No	Yes	1	9	9
61	E:E:N113	E:E:P114	4.89	No	No	0	9	5
62	E:E:I119	E:E:L115	5.71	No	No	0	5	4
63	E:E:E117	E:E:F121	2.33	No	No	0	8	6
64	E:E:E117	R:R:T68	2.82	No	Yes	0	8	5
65	E:E:E122	E:E:R118	2.33	No	No	0	4	4
66	E:E:I120	R:R:Y49	4.84	No	Yes	0	9	3
67	E:E:I120	R:R:W69	2.35	No	Yes	0	9	7
68	E:E:H127	E:E:T123	4.11	Yes	No	3	8	8
69	E:E:F128	E:E:H124	13.58	Yes	No	3	9	9
70	E:E:H124	R:R:Y49	21.78	No	Yes	3	9	3
71	E:E:H124	R:R:M53	21.01	No	No	0	9	2
72	E:E:F128	E:E:H127	13.58	Yes	Yes	3	9	8
73	E:E:H127	R:R:Y49	3.27	Yes	Yes	3	8	3
74	E:E:C131	E:E:F128	13.97	No	Yes	3	9	9
75	E:E:F128	R:R:Y49	26.82	Yes	Yes	3	9	3
76	E:E:C131	R:R:Q50	3.05	No	Yes	0	9	4
77	E:E:L133	E:E:Q135	3.99	No	No	0	4	5
78	E:E:P136	E:E:V134	3.53	No	No	0	6	5
79	E:E:T137	R:R:D280	14.45	No	No	0	6	4
80	E:E:F138	R:R:Y278	14.44	No	Yes	1	4	6
81	E:E:F138	R:R:D287	10.75	No	No	1	4	3
82	E:E:D140	R:R:Y278	2.3	No	Yes	0	9	6
83	E:E:L146	E:E:P141	4.93	Yes	No	1	8	9
84	E:E:P141	R:R:Y277	15.3	No	Yes	1	9	3
85	E:E:P141	R:R:L290	11.49	No	Yes	1	9	3
86	E:E:P142	E:E:V145	12.37	No	No	1	9	7
87	E:E:P142	R:R:Y277	6.95	No	Yes	1	9	3
88	E:E:E143	E:E:L146	2.65	No	Yes	0	7	8
89	E:E:M149	E:E:V145	4.56	Yes	No	1	9	7
90	E:E:V145	R:R:Y277	3.79	No	Yes	1	7	3
91	E:E:L146	E:E:M149	2.83	Yes	Yes	1	8	9
92	E:E:I150	E:E:L146	2.85	Yes	Yes	0	9	8
93	E:E:L146	R:R:H289	3.86	Yes	No	1	8	4
94	E:E:L146	R:R:L290	2.77	Yes	Yes	1	8	3
95	E:E:I151	E:E:L147	5.71	Yes	No	0	6	7
96	E:E:M149	R:R:A273	3.22	Yes	No	0	9	5
97	E:E:M149	R:R:Y277	2.39	Yes	Yes	1	9	3
98	E:E:I150	R:R:Y292	4.84	Yes	Yes	0	9	6
99	E:E:I150	R:R:I293	5.89	Yes	No	0	9	8
100	E:E:P153	R:R:P297	5.84	No	Yes	0	9	8
101	E:E:I154	E:E:I157	2.94	Yes	Yes	2	9	9
102	E:E:I154	R:R:P297	6.77	Yes	Yes	0	9	8
103	E:E:F159	E:E:L156	2.44	No	No	0	8	9
104	E:E:L156	E:E:L160	2.77	No	Yes	2	9	9
105	E:E:L156	R:R:F262	2.44	No	Yes	2	9	4
106	E:E:I157	E:E:P158	3.39	Yes	No	0	9	9
107	E:E:I157	R:R:F228	5.02	Yes	Yes	2	9	5
108	E:E:I157	R:R:F262	2.51	Yes	Yes	2	9	4
109	E:E:L160	R:R:F257	2.44	Yes	No	0	9	3
110	E:E:L160	R:R:L258	2.77	Yes	Yes	2	9	6
111	E:E:L160	R:R:F262	7.31	Yes	Yes	2	9	4
112	E:E:I161	R:R:I235	2.94	No	Yes	0	9	6
113	E:E:V164	R:R:W254	3.68	No	No	0	9	2
114	E:E:V164	R:R:Y255	8.83	No	Yes	0	9	8
115	E:E:V165	E:E:W166	3.68	No	No	0	9	8
116	E:E:R167	E:E:W166	6	No	No	0	8	8
117	L:L:F14	L:L:G15	3.01	Yes	No	1	0	0
118	L:L:F14	L:L:R17	7.48	Yes	No	0	0	0
119	L:L:F14	R:R:H289	13.58	Yes	No	1	0	4
120	L:L:F14	R:R:Y292	5.16	Yes	Yes	0	0	6
121	L:L:G15	R:R:H289	3.18	No	No	1	0	4
122	L:L:C16	L:L:C21	7.28	No	No	0	0	0
123	L:L:C16	R:R:L291	3.17	No	No	0	0	5
124	L:L:C16	R:R:Y292	8.06	No	Yes	0	0	6
125	L:L:F18	R:R:Y292	5.16	No	Yes	0	0	6
126	L:L:F18	R:R:C299	9.78	No	No	0	0	4
127	L:L:T20	R:R:Y227	4.99	No	Yes	4	0	8
128	L:L:T20	R:R:H295	9.58	No	Yes	0	0	6
129	L:L:T20	R:R:I298	3.04	No	No	4	0	7
130	L:L:C21	R:R:H295	8.85	No	Yes	0	0	6
131	L:L:T22	R:R:H370	9.58	No	Yes	0	0	7
132	L:L:T22	R:R:M373	3.01	No	Yes	0	0	7
133	L:L:Q24	L:L:V23	4.3	Yes	No	0	0	0
134	L:L:V23	R:R:M223	4.56	No	No	0	0	6
135	L:L:Q24	R:R:H219	6.18	Yes	Yes	1	0	6
136	L:L:Q24	R:R:L220	3.99	Yes	Yes	1	0	7
137	L:L:Q24	R:R:L291	2.66	Yes	No	0	0	5
138	L:L:Q24	R:R:H295	7.42	Yes	Yes	0	0	6
139	L:L:K25	R:R:S286	3.06	No	No	0	0	7
140	L:L:H28	L:L:Y31	8.71	No	Yes	1	0	0
141	L:L:H28	R:R:S285	6.97	No	Yes	1	0	5
142	L:L:H28	R:R:S286	6.97	No	No	0	0	7
143	L:L:Q29	L:L:Q32	2.56	No	Yes	0	0	0
144	L:L:Q32	L:L:Y31	2.25	Yes	Yes	1	0	0
145	L:L:Y31	R:R:Q202	6.76	Yes	No	0	0	2
146	L:L:Y31	R:R:I284	22.97	Yes	No	0	0	6
147	L:L:Y31	R:R:S285	2.54	Yes	Yes	1	0	5
148	L:L:F33	L:L:Q32	12.88	Yes	Yes	1	0	0
149	L:L:Q32	R:R:D90	5.22	Yes	No	1	0	3
150	L:L:Q32	R:R:P97	12.63	Yes	Yes	1	0	3
151	L:L:F33	R:R:D96	2.39	Yes	Yes	1	0	5
152	L:L:F33	R:R:T131	2.59	Yes	No	1	0	1
153	L:L:F33	R:R:K134	12.41	Yes	Yes	1	0	3
154	L:L:F33	R:R:V135	10.49	Yes	No	0	0	1
155	L:L:F33	R:R:A138	2.77	Yes	No	0	0	5
156	L:L:T34	R:R:N200	4.39	No	No	0	0	3
157	L:L:D35	L:L:D37	3.99	No	Yes	0	0	0
158	L:L:D35	L:L:K38	11.06	No	No	0	0	0
159	L:L:D37	R:R:V36	10.22	Yes	No	0	0	2
160	L:L:D37	R:R:T37	13.01	Yes	No	0	0	4
161	L:L:K38	R:R:Q93	10.85	No	No	0	0	4
162	L:L:D39	L:L:V41	5.84	No	No	0	0	0
163	L:L:D39	R:R:F92	3.58	No	Yes	0	0	6
164	L:L:N40	L:L:V41	4.43	No	No	0	0	0
165	L:L:N40	R:R:Q93	5.28	No	No	0	0	4
166	L:L:N40	R:R:D94	16.16	No	No	0	0	5
167	L:L:A42	R:R:F92	2.77	No	Yes	1	0	6
168	L:L:A42	R:R:F95	2.77	No	Yes	1	0	5
169	L:L:A42	R:R:Y124	4	No	Yes	1	0	4
170	L:L:K46	L:L:P43	3.35	Yes	No	0	0	0
171	L:L:I47	L:L:R44	2.51	Yes	No	0	0	0
172	L:L:Q50	L:L:S45	8.66	No	No	0	0	0
173	L:L:G51	L:L:K46	5.23	No	Yes	1	0	0
174	L:L:K46	L:L:Y52	11.94	Yes	Yes	1	0	0
175	L:L:K46	R:R:R119	4.95	Yes	Yes	1	0	4
176	L:L:I47	L:L:S48	3.1	Yes	No	0	0	0
177	L:L:I47	R:R:Y124	20.55	Yes	Yes	1	0	4
178	L:L:I47	R:R:T125	4.56	Yes	No	1	0	6
179	L:L:I47	R:R:N128	5.66	Yes	Yes	1	0	3
180	L:L:P49	L:L:S48	3.56	No	No	0	0	0
181	L:L:P49	R:R:H114	18.3	No	Yes	7	0	4
182	L:L:P49	R:R:W121	13.51	No	No	7	0	8
183	L:L:Q50	R:R:S117	8.66	No	No	0	0	4
184	L:L:G51	R:R:R119	6	No	Yes	1	0	4
185	L:L:Y52	R:R:D70	12.64	Yes	No	1	0	9
186	L:L:Y52	R:R:G71	5.79	Yes	No	1	0	4
187	L:L:Y52	R:R:W72	29.9	Yes	Yes	1	0	5
188	L:L:Y52	R:R:Y124	14.89	Yes	Yes	1	0	4
189	R:R:K40	R:R:V36	4.55	No	No	0	5	2
190	R:R:T37	R:R:Y91	18.73	No	Yes	1	4	5
191	R:R:F92	R:R:T37	2.59	Yes	No	1	6	4
192	R:R:M42	R:R:R38	6.2	Yes	No	3	3	5
193	R:R:K40	R:R:N39	2.8	No	No	0	5	5
194	R:R:M42	R:R:N39	4.21	Yes	No	0	3	5
195	R:R:N39	R:R:T43	4.39	No	No	0	5	5
196	R:R:I41	R:R:Q45	2.74	Yes	Yes	0	6	5
197	R:R:I41	R:R:W72	5.87	Yes	Yes	1	6	5
198	R:R:I41	R:R:Y91	8.46	Yes	Yes	1	6	5
199	R:R:E47	R:R:T43	2.82	No	No	0	6	5
200	R:R:Q45	R:R:W69	8.76	Yes	Yes	0	5	7
201	R:R:Y46	R:R:Y49	33.76	No	Yes	3	2	3
202	R:R:E47	R:R:Q50	5.1	No	Yes	0	6	4
203	R:R:C48	R:R:W69	2.61	No	Yes	0	9	7
204	R:R:C48	R:R:C74	7.28	No	No	0	9	9
205	R:R:Q50	R:R:Q54	5.12	Yes	No	0	4	2
206	R:R:K51	R:R:R67	11.14	No	Yes	0	3	4
207	R:R:C74	R:R:K51	8.08	No	No	0	9	3
208	R:R:I52	R:R:R67	3.76	No	Yes	0	5	4
209	R:R:D55	R:R:Q54	5.22	No	No	0	4	2
210	R:R:D55	R:R:I57	2.8	No	No	0	4	1
211	R:R:Q58	R:R:Y64	7.89	No	Yes	8	1	3
212	R:R:D77	R:R:Q58	9.14	Yes	No	8	4	1
213	R:R:E61	R:R:Y64	3.37	No	Yes	0	1	3
214	R:R:G62	R:R:Y64	2.9	No	Yes	0	1	3
215	R:R:N66	R:R:Y64	4.65	No	Yes	8	5	3
216	R:R:D77	R:R:Y64	9.2	Yes	Yes	8	4	3
217	R:R:C65	R:R:W75	9.14	No	Yes	1	9	9
218	R:R:C105	R:R:C65	7.28	No	No	1	9	9
219	R:R:D77	R:R:N66	4.04	Yes	No	8	4	5
220	R:R:N76	R:R:R67	7.23	No	Yes	0	6	4
221	R:R:D77	R:R:R67	11.91	Yes	Yes	0	4	4
222	R:R:T68	R:R:W75	4.85	Yes	Yes	1	5	9
223	R:R:T68	R:R:W111	7.28	Yes	Yes	1	5	9
224	R:R:G71	R:R:W69	2.81	No	Yes	0	4	7
225	R:R:D70	R:R:G71	3.35	No	No	1	9	4
226	R:R:D70	R:R:W111	3.35	No	Yes	1	9	9
227	R:R:W72	R:R:Y91	18.33	Yes	Yes	1	5	5
228	R:R:F95	R:R:W72	5.01	Yes	Yes	1	5	5
229	R:R:L73	R:R:P89	11.49	No	No	0	5	8
230	R:R:V78	R:R:W75	3.68	No	Yes	1	7	9
231	R:R:S84	R:R:W75	9.88	No	Yes	1	7	9
232	R:R:K103	R:R:W75	4.64	No	Yes	0	8	9
233	R:R:C105	R:R:W75	9.14	No	Yes	1	9	9
234	R:R:W111	R:R:W75	26.24	Yes	Yes	1	9	9
235	R:R:S84	R:R:V78	9.7	No	No	1	7	7
236	R:R:G81	R:R:Q107	4.93	No	No	0	7	3
237	R:R:E83	R:R:T102	2.82	No	No	0	3	5
238	R:R:E83	R:R:I104	15.03	No	No	0	3	4
239	R:R:K100	R:R:M85	7.2	No	No	0	3	4
240	R:R:C88	R:R:E99	3.04	Yes	Yes	1	9	5
241	R:R:C88	R:R:V101	5.12	Yes	No	1	9	7
242	R:R:C127	R:R:C88	7.28	Yes	Yes	1	9	9
243	R:R:D90	R:R:P97	8.05	No	Yes	1	3	3
244	R:R:F92	R:R:Y91	18.57	Yes	Yes	1	6	5
245	R:R:F92	R:R:F95	22.51	Yes	Yes	1	6	5
246	R:R:D94	R:R:N128	5.39	No	Yes	0	5	3
247	R:R:F95	R:R:Y124	14.44	Yes	Yes	1	5	4
248	R:R:C127	R:R:F95	4.19	Yes	Yes	1	9	5
249	R:R:D96	R:R:P97	6.44	Yes	Yes	1	5	3
250	R:R:D96	R:R:E99	2.6	Yes	Yes	1	5	5
251	R:R:D96	R:R:N130	12.12	Yes	Yes	1	5	2
252	R:R:D96	R:R:T131	11.56	Yes	No	1	5	1
253	R:R:D96	R:R:K134	12.44	Yes	Yes	1	5	3
254	R:R:P97	R:R:S98	3.56	Yes	No	0	3	3
255	R:R:K134	R:R:S98	7.65	Yes	No	0	3	3
256	R:R:E99	R:R:K100	2.7	Yes	No	0	5	3
257	R:R:E99	R:R:Q126	12.74	Yes	No	0	5	5
258	R:R:C127	R:R:E99	3.04	Yes	Yes	1	9	5
259	R:R:E99	R:R:N130	9.2	Yes	Yes	1	5	2
260	R:R:K103	R:R:V101	7.59	No	No	0	8	7
261	R:R:C127	R:R:V101	3.42	Yes	No	1	9	7
262	R:R:N123	R:R:T102	4.39	No	No	0	8	5
263	R:R:K103	R:R:T122	7.51	No	No	0	8	7
264	R:R:F112	R:R:I104	12.56	No	No	0	5	4
265	R:R:C105	R:R:W111	3.92	No	Yes	1	9	9
266	R:R:D106	R:R:D108	10.65	Yes	No	0	5	5
267	R:R:D106	R:R:N110	6.73	Yes	No	0	5	5
268	R:R:D106	R:R:F112	5.97	Yes	No	0	5	5
269	R:R:N110	R:R:R113	13.26	No	No	0	5	1
270	R:R:T120	R:R:W111	13.34	No	Yes	0	5	9
271	R:R:N118	R:R:R113	2.41	No	No	0	6	1
272	R:R:H114	R:R:P115	4.58	Yes	No	7	4	3
273	R:R:A116	R:R:H114	7.32	No	Yes	0	3	4
274	R:R:H114	R:R:W121	10.58	Yes	No	7	4	8
275	R:R:P115	R:R:W121	4.05	No	No	7	3	8
276	R:R:N123	R:R:T125	11.7	No	No	0	8	6
277	R:R:N128	R:R:Y124	2.33	Yes	Yes	1	3	4
278	R:R:N128	R:R:T125	2.92	Yes	No	1	3	6
279	R:R:N128	R:R:V129	4.43	Yes	No	0	3	2
280	R:R:E133	R:R:N130	6.57	No	Yes	1	1	2
281	R:R:K134	R:R:N130	6.99	Yes	Yes	1	3	2
282	R:R:H132	R:R:K136	18.34	No	No	0	2	2
283	R:R:E133	R:R:K134	5.4	No	Yes	1	1	3
284	R:R:K136	R:R:V135	6.07	No	No	0	2	1
285	R:R:T137	R:R:Y367	2.5	No	No	0	4	6
286	R:R:L141	R:R:Y367	3.52	No	No	0	6	6
287	R:R:H370	R:R:L141	3.86	Yes	No	0	7	6
288	R:R:F142	R:R:Y143	5.16	Yes	No	0	6	4
289	R:R:F142	R:R:I146	6.28	Yes	No	6	6	6
290	R:R:F142	R:R:L195	4.87	Yes	No	6	6	7
291	R:R:F142	R:R:T196	2.59	Yes	No	6	6	3
292	R:R:I371	R:R:L144	5.71	No	No	0	6	6
293	R:R:H149	R:R:T145	2.74	Yes	No	5	7	7
294	R:R:H374	R:R:T145	17.8	Yes	No	5	9	7
295	R:R:I146	R:R:T196	3.04	No	No	6	6	3
296	R:R:I147	R:R:L151	2.85	No	No	0	5	5
297	R:R:F375	R:R:G148	9.03	No	No	0	7	9
298	R:R:H149	R:R:S188	5.58	Yes	No	5	7	8
299	R:R:H149	R:R:T191	6.85	Yes	No	0	7	7
300	R:R:H149	R:R:I192	2.65	Yes	No	0	7	6
301	R:R:H149	R:R:H374	3.58	Yes	Yes	5	7	9
302	R:R:G150	R:R:I153	3.53	No	Yes	0	7	6
303	R:R:F375	R:R:L151	2.44	No	No	0	7	5
304	R:R:G377	R:R:S152	3.71	No	No	0	9	9
305	R:R:I153	R:R:L157	2.85	Yes	No	0	6	3
306	R:R:I153	R:R:S188	7.74	Yes	No	5	6	8
307	R:R:I153	R:R:V189	3.07	Yes	No	5	6	4
308	R:R:L378	R:R:S155	4.5	No	No	0	6	6
309	R:R:S155	R:R:S381	3.26	No	Yes	4	6	8
310	R:R:F386	R:R:S155	2.64	Yes	No	4	8	6
311	R:R:L156	R:R:S159	3	Yes	Yes	4	9	8
312	R:R:F181	R:R:L156	6.09	Yes	Yes	4	8	9
313	R:R:F184	R:R:L156	7.31	Yes	Yes	4	8	9
314	R:R:L156	R:R:V185	4.47	Yes	No	0	9	7
315	R:R:G377	R:R:L156	5.13	No	Yes	0	9	9
316	R:R:L156	R:R:S381	3	Yes	Yes	4	9	8
317	R:R:F386	R:R:I158	3.77	Yes	No	0	8	5
318	R:R:F181	R:R:S159	9.25	Yes	Yes	4	8	8
319	R:R:S159	R:R:S381	6.52	Yes	Yes	4	8	8
320	R:R:C385	R:R:S159	3.44	Yes	Yes	0	9	8
321	R:R:F164	R:R:L160	2.44	No	Yes	4	4	5
322	R:R:K178	R:R:L160	2.82	Yes	Yes	4	6	5
323	R:R:F181	R:R:L160	7.31	Yes	Yes	4	8	5
324	R:R:F182	R:R:L160	2.44	No	Yes	0	4	5
325	R:R:F166	R:R:I162	6.28	Yes	No	0	7	8
326	R:R:C385	R:R:I162	4.91	Yes	No	0	9	8
327	R:R:F163	R:R:I174	2.51	Yes	Yes	4	7	9
328	R:R:F163	R:R:K178	3.72	Yes	Yes	4	7	6
329	R:R:F163	R:R:F181	6.43	Yes	Yes	4	7	8
330	R:R:C385	R:R:F163	4.19	Yes	Yes	0	9	7
331	R:R:F164	R:R:K178	16.13	No	Yes	4	4	6
332	R:R:F166	R:R:I394	3.77	Yes	No	0	7	8
333	R:R:F166	R:R:L395	4.87	Yes	No	0	7	5
334	R:R:F166	R:R:N398	2.42	Yes	No	0	7	5
335	R:R:L169	R:R:V391	2.98	No	No	0	9	9
336	R:R:I394	R:R:L169	4.28	No	No	0	8	9
337	R:R:C171	R:R:I174	3.27	No	Yes	0	8	9
338	R:R:Q172	R:R:Y236	10.15	Yes	Yes	0	7	8
339	R:R:K249	R:R:Q172	2.71	No	Yes	0	5	7
340	R:R:Q172	R:R:Q250	3.84	Yes	No	0	7	6
341	R:R:L252	R:R:Q172	3.99	Yes	Yes	0	6	7
342	R:R:I174	R:R:R173	7.52	Yes	No	0	9	9
343	R:R:H177	R:R:R173	2.26	Yes	No	0	9	9
344	R:R:E390	R:R:R173	3.49	No	No	0	9	9
345	R:R:I174	R:R:K178	2.91	Yes	Yes	4	9	6
346	R:R:L252	R:R:T175	2.95	Yes	No	0	6	6
347	R:R:T175	R:R:Y256	2.5	No	No	0	6	5
348	R:R:L176	R:R:W229	2.28	Yes	Yes	2	9	9
349	R:R:E233	R:R:L176	3.98	No	Yes	2	9	9
350	R:R:L176	R:R:Y236	4.69	Yes	Yes	2	9	8
351	R:R:L176	R:R:L252	2.77	Yes	Yes	2	9	6
352	R:R:L176	R:R:Y255	3.52	Yes	Yes	2	9	8
353	R:R:E233	R:R:H177	16	No	Yes	2	9	9
354	R:R:H177	R:R:L344	3.86	Yes	Yes	2	9	9
355	R:R:F384	R:R:H177	4.53	No	Yes	2	8	9
356	R:R:N179	R:R:W229	19.21	No	Yes	2	8	9
357	R:R:N179	R:R:Y256	12.79	No	No	0	8	5
358	R:R:N179	R:R:W260	5.65	No	Yes	2	8	9
359	R:R:F181	R:R:L180	2.44	Yes	No	0	8	9
360	R:R:F184	R:R:L180	7.31	Yes	No	0	8	9
361	R:R:F181	R:R:V380	3.93	Yes	No	0	8	9
362	R:R:C186	R:R:F182	4.19	No	No	0	7	4
363	R:R:F182	R:R:W260	3.01	No	Yes	0	4	9
364	R:R:N226	R:R:S183	5.96	No	No	0	8	8
365	R:R:S183	R:R:W229	3.71	No	Yes	2	8	9
366	R:R:S183	R:R:W260	4.94	No	Yes	2	8	9
367	R:R:F184	R:R:N226	18.12	Yes	No	0	8	8
368	R:R:F184	R:R:M230	3.73	Yes	Yes	4	8	9
369	R:R:F184	R:R:Q376	3.51	Yes	No	4	8	9
370	R:R:F184	R:R:V380	3.93	Yes	No	0	8	9
371	R:R:C186	R:R:L222	4.76	No	No	0	7	5
372	R:R:H219	R:R:N187	2.55	Yes	No	0	6	8
373	R:R:N187	R:R:N226	5.45	No	No	0	8	8
374	R:R:S188	R:R:V189	3.23	No	No	5	8	4
375	R:R:H219	R:R:V190	4.15	Yes	No	0	6	6
376	R:R:L222	R:R:V190	2.98	No	No	0	5	6
377	R:R:H219	R:R:T191	6.85	Yes	No	0	6	7
378	R:R:H194	R:R:V198	11.07	No	No	1	7	6
379	R:R:H194	R:R:S215	6.97	No	No	1	7	6
380	R:R:H194	R:R:Q216	3.71	No	Yes	1	7	6
381	R:R:L204	R:R:V198	5.96	Yes	No	1	4	6
382	R:R:S215	R:R:V198	3.23	No	No	1	6	6
383	R:R:A203	R:R:N201	4.69	No	No	0	4	4
384	R:R:L204	R:R:N201	5.49	Yes	No	0	4	4
385	R:R:Q202	R:R:V205	8.6	No	No	0	2	4
386	R:R:L204	R:R:P209	3.28	Yes	No	1	4	5
387	R:R:C212	R:R:L204	3.17	Yes	Yes	1	9	4
388	R:R:I284	R:R:V205	3.07	No	No	0	6	4
389	R:R:P209	R:R:T207	6.99	No	No	0	5	3
390	R:R:K213	R:R:N208	4.2	Yes	No	1	8	6
391	R:R:C282	R:R:N208	4.72	No	No	1	9	6
392	R:R:C212	R:R:P209	5.65	Yes	No	1	9	5
393	R:R:K213	R:R:V210	6.07	Yes	No	0	8	4
394	R:R:C212	R:R:K213	3.23	Yes	Yes	1	9	8
395	R:R:C212	R:R:C282	7.28	Yes	No	1	9	9
396	R:R:C282	R:R:K213	3.23	No	Yes	1	9	8
397	R:R:K213	R:R:W283	15.08	Yes	Yes	0	8	8
398	R:R:L220	R:R:Q216	7.99	Yes	Yes	1	7	6
399	R:R:H270	R:R:Q216	7.42	Yes	Yes	1	8	6
400	R:R:Q216	R:R:W283	6.57	Yes	Yes	0	6	8
401	R:R:F217	R:R:I218	3.77	Yes	No	0	6	5
402	R:R:A267	R:R:F217	4.16	No	Yes	0	6	6
403	R:R:C268	R:R:F217	4.19	No	Yes	0	2	6
404	R:R:A271	R:R:F217	2.77	No	Yes	0	5	6
405	R:R:H219	R:R:L220	3.86	Yes	Yes	1	6	7
406	R:R:H270	R:R:L220	6.43	Yes	Yes	1	8	7
407	R:R:I294	R:R:L220	8.56	No	Yes	1	7	7
408	R:R:L222	R:R:Y221	4.69	No	Yes	0	5	8
409	R:R:C225	R:R:Y221	9.41	No	Yes	2	8	8
410	R:R:P263	R:R:Y221	2.78	Yes	Yes	2	9	8
411	R:R:L264	R:R:Y221	10.55	No	Yes	0	3	8
412	R:R:M223	R:R:Y227	4.79	No	Yes	0	6	8
413	R:R:H295	R:R:M223	2.63	Yes	No	0	6	6
414	R:R:G224	R:R:I298	3.53	No	No	0	5	7
415	R:R:C225	R:R:W260	5.22	No	Yes	2	8	9
416	R:R:C225	R:R:P263	7.53	No	Yes	2	8	9
417	R:R:M230	R:R:Y227	4.79	Yes	Yes	4	9	8
418	R:R:I298	R:R:Y227	14.51	No	Yes	4	7	8
419	R:R:F349	R:R:Y227	9.28	No	Yes	0	8	8
420	R:R:F228	R:R:L231	2.44	Yes	Yes	2	5	8
421	R:R:F228	R:R:L258	3.65	Yes	Yes	2	5	6
422	R:R:F228	R:R:F262	8.57	Yes	Yes	2	5	4
423	R:R:F228	R:R:P263	4.33	Yes	Yes	2	5	9
424	R:R:F228	R:R:P297	2.89	Yes	Yes	0	5	8
425	R:R:C232	R:R:W229	6.53	No	Yes	0	7	9
426	R:R:G259	R:R:W229	8.44	No	Yes	0	9	9
427	R:R:W229	R:R:W260	17.81	Yes	Yes	2	9	9
428	R:R:G346	R:R:M230	3.49	No	Yes	0	9	9
429	R:R:M230	R:R:Q376	5.44	Yes	No	4	9	9
430	R:R:I235	R:R:L231	5.71	Yes	Yes	0	6	8
431	R:R:L231	R:R:L258	2.77	Yes	Yes	2	8	6
432	R:R:A301	R:R:L231	3.15	No	Yes	0	7	8
433	R:R:L231	R:R:N305	5.49	Yes	No	0	8	9
434	R:R:C232	R:R:L258	4.76	No	Yes	0	7	6
435	R:R:E233	R:R:L344	5.3	No	Yes	2	9	9
436	R:R:I235	R:R:Y255	4.84	Yes	Yes	0	6	8
437	R:R:F308	R:R:I235	5.02	No	Yes	0	8	6
438	R:R:L240	R:R:Y236	12.89	No	Yes	0	8	8
439	R:R:Y236	R:R:Y255	3.97	Yes	Yes	2	8	8
440	R:R:L237	R:R:L344	2.77	No	Yes	0	9	9
441	R:R:H238	R:R:V242	15.22	Yes	No	11	8	6
442	R:R:H238	R:R:V243	2.77	Yes	No	0	8	5
443	R:R:F308	R:R:H238	18.1	No	Yes	0	8	8
444	R:R:H238	R:R:N311	8.93	Yes	Yes	11	8	7
445	R:R:I241	R:R:I312	5.89	No	No	0	8	9
446	R:R:N311	R:R:V242	2.96	Yes	No	11	7	6
447	R:R:V242	R:R:V315	3.21	No	No	0	6	8
448	R:R:Q250	R:R:Y255	2.25	No	Yes	0	6	8
449	R:R:H251	R:R:M253	7.88	No	No	0	4	3
450	R:R:L252	R:R:Y255	3.52	Yes	Yes	2	6	8
451	R:R:M253	R:R:W254	5.82	No	No	0	3	2
452	R:R:F262	R:R:L258	2.44	Yes	Yes	2	4	6
453	R:R:F262	R:R:P263	4.33	Yes	Yes	2	4	9
454	R:R:F262	R:R:I265	2.51	Yes	No	0	4	4
455	R:R:I265	R:R:P266	3.39	No	No	0	4	6
456	R:R:I269	R:R:I293	2.94	No	No	0	5	8
457	R:R:H270	R:R:R274	11.28	Yes	Yes	1	8	7
458	R:R:H270	R:R:L290	2.57	Yes	Yes	1	8	3
459	R:R:H270	R:R:I294	6.63	Yes	No	1	8	7
460	R:R:R274	R:R:Y278	10.29	Yes	Yes	1	7	6
461	R:R:R274	R:R:W283	20.99	Yes	Yes	0	7	8
462	R:R:R274	R:R:T288	7.76	Yes	No	1	7	5
463	R:R:L290	R:R:R274	7.29	Yes	Yes	1	3	7
464	R:R:N279	R:R:S275	4.47	No	No	0	6	3
465	R:R:L276	R:R:Y277	15.24	No	Yes	0	3	3
466	R:R:D280	R:R:Y278	14.94	No	Yes	0	4	6
467	R:R:S285	R:R:Y278	7.63	Yes	Yes	1	5	6
468	R:R:D287	R:R:Y278	12.64	No	Yes	1	3	6
469	R:R:T288	R:R:Y278	7.49	No	Yes	1	5	6
470	R:R:N279	R:R:W283	14.69	No	Yes	0	6	8
471	R:R:D280	R:R:N281	4.04	No	No	0	4	4
472	R:R:D287	R:R:S285	5.89	No	Yes	1	3	5
473	R:R:L291	R:R:S286	3	No	No	0	5	7
474	R:R:L290	R:R:T288	13.27	Yes	No	1	3	5
475	R:R:I293	R:R:L290	2.85	No	Yes	0	8	3
476	R:R:G296	R:R:P297	4.06	No	Yes	0	4	8
477	R:R:F349	R:R:L302	3.65	No	No	0	8	7
478	R:R:I347	R:R:L306	4.28	Yes	No	12	7	5
479	R:R:L306	R:R:V350	4.47	No	No	12	5	6
480	R:R:F307	R:R:F308	5.36	No	No	0	4	8
481	R:R:F307	R:R:N311	10.87	No	Yes	0	4	7
482	R:R:L309	R:R:V313	2.98	Yes	No	0	9	6
483	R:R:L309	R:R:L341	4.15	Yes	No	0	9	9
484	R:R:L309	R:R:L345	4.15	Yes	Yes	0	9	9
485	R:R:N311	R:R:R314	6.03	Yes	No	0	7	7
486	R:R:I312	R:R:L341	2.85	No	No	0	9	9
487	R:R:T338	R:R:V313	3.17	No	No	0	9	6
488	R:R:R314	R:R:V315	3.92	No	No	0	7	8
489	R:R:A334	R:R:I317	3.25	No	No	0	8	5
490	R:R:K321	R:R:L330	2.82	No	No	0	6	6
491	R:R:M332	R:R:Y331	2.39	No	No	0	6	7
492	R:R:I340	R:R:R336	6.26	No	No	0	8	8
493	R:R:L339	R:R:T338	2.95	No	No	0	7	9
494	R:R:P343	R:R:V342	3.53	No	No	0	9	8
495	R:R:I347	R:R:V342	3.07	Yes	No	0	7	8
496	R:R:L379	R:R:P343	3.28	No	No	0	5	9
497	R:R:L344	R:R:L345	4.15	Yes	Yes	0	9	9
498	R:R:F384	R:R:L344	13.4	No	Yes	2	8	9
499	R:R:I347	R:R:L345	2.85	Yes	Yes	0	7	9
500	R:R:I347	R:R:V350	4.61	Yes	No	12	7	6
501	R:R:E348	R:R:L372	5.3	No	No	0	8	6
502	R:R:E348	R:R:Q376	16.57	No	No	0	8	9
503	R:R:E348	R:R:L379	2.65	No	No	0	8	5
504	R:R:F349	R:R:M373	9.95	No	Yes	0	8	7
505	R:R:I352	R:R:P353	3.39	No	No	0	7	6
506	R:R:I352	R:R:Y365	6.04	No	No	0	7	6
507	R:R:I352	R:R:M369	2.92	No	Yes	0	7	8
508	R:R:E363	R:R:Y365	4.49	No	No	0	4	6
509	R:R:I368	R:R:V364	3.07	No	No	0	4	4
510	R:R:D366	R:R:M369	2.77	No	Yes	5	6	8
511	R:R:D366	R:R:H370	7.56	No	Yes	5	6	7
512	R:R:I368	R:R:I371	4.42	No	No	0	4	6
513	R:R:H370	R:R:M369	3.94	Yes	Yes	5	7	8
514	R:R:M369	R:R:M373	4.33	Yes	Yes	0	8	7
515	R:R:H370	R:R:H374	9.55	Yes	Yes	5	7	9
516	R:R:H374	R:R:M373	14.44	Yes	Yes	0	9	7
517	R:R:F375	R:R:L378	3.65	No	No	0	7	6
518	R:R:F386	R:R:S381	5.28	Yes	Yes	4	8	8
519	R:R:F386	R:R:T382	5.19	Yes	No	0	8	5
520	R:R:F387	R:R:T382	6.49	No	No	0	5	5
521	R:R:F384	R:R:I383	7.54	No	No	0	8	7
522	R:R:C385	R:R:F386	5.59	Yes	Yes	0	9	8
523	R:R:E390	R:R:N388	11.83	No	No	0	9	9
524	R:R:N388	R:R:V391	5.91	No	No	0	9	9
525	R:R:Q392	R:R:R396	12.85	No	No	0	7	5
526	R:R:I394	R:R:R397	3.76	No	No	0	8	7
527	R:R:N398	R:R:Q401	5.28	No	No	0	5	6
528	R:R:Q401	R:R:Y402	3.38	No	No	0	6	3
529	R:R:G261	R:R:P263	2.03	No	Yes	0	7	9
530	E:E:R167	R:R:W254	2	No	No	0	8	2
531	R:R:A80	R:R:G81	1.95	No	No	0	6	7
532	R:R:C88	R:R:P89	1.88	Yes	No	0	9	8
533	E:E:A116	E:E:P112	1.87	No	No	0	9	9
534	E:E:A152	E:E:P153	1.87	No	No	0	7	9
535	L:L:G19	L:L:T22	1.82	No	No	0	0	0
536	R:R:G81	R:R:T82	1.82	No	No	0	7	5
537	L:L:A27	R:R:A199	1.79	No	Yes	6	0	4
538	E:E:P136	E:E:S139	1.78	No	No	0	6	5
539	R:R:G234	R:R:L345	1.71	No	Yes	0	8	9
540	R:R:A80	R:R:V63	1.7	No	No	0	6	1
541	R:R:A244	R:R:V243	1.7	No	No	0	6	5
542	R:R:G389	R:R:N388	1.7	No	No	0	6	9
543	L:L:D37	R:R:G35	1.68	Yes	No	0	0	2
544	R:R:A79	R:R:T82	1.68	No	No	0	1	5
545	R:R:A244	R:R:T239	1.68	No	No	0	6	7
546	E:E:C155	E:E:I151	1.64	No	Yes	0	7	6
547	R:R:G389	R:R:Q392	1.64	No	No	0	6	7
548	E:E:I154	R:R:A300	1.62	Yes	No	2	9	3
549	E:E:I157	R:R:A300	1.62	Yes	No	2	9	3
550	L:L:I30	R:R:A199	1.62	No	Yes	0	0	4
551	R:R:A199	R:R:I284	1.62	Yes	No	0	4	6
552	R:R:A267	R:R:I294	1.62	No	No	0	6	7
553	R:R:A271	R:R:I272	1.62	No	No	0	5	4
554	R:R:D55	R:R:P56	1.61	No	No	0	4	3
555	R:R:T338	R:R:V335	1.59	No	No	0	9	8
556	E:E:A104	E:E:L109	1.58	No	No	0	9	7
557	E:E:P136	E:E:Q135	1.58	No	No	0	6	5
558	L:L:A27	R:R:L195	1.58	No	No	6	0	7
559	R:R:A199	R:R:L195	1.58	Yes	No	6	4	7
560	R:R:A337	R:R:L316	1.58	No	No	0	9	8
561	R:R:I193	R:R:V189	1.54	No	No	0	5	4
562	L:L:K46	L:L:S45	1.53	Yes	No	0	0	0
563	E:E:I161	E:E:T162	1.52	No	No	0	9	8
564	R:R:A44	R:R:Q45	1.52	No	Yes	0	6	5
565	R:R:L139	R:R:V135	1.49	No	No	0	3	1
566	R:R:L231	R:R:V304	1.49	Yes	No	0	8	6
567	E:E:I150	E:E:I151	1.47	Yes	Yes	0	9	6
568	E:E:I151	E:E:I154	1.47	Yes	Yes	0	6	9
569	E:E:L163	E:E:T162	1.47	No	No	0	9	8
570	L:L:L26	R:R:T145	1.47	No	No	0	0	7
571	R:R:I340	R:R:I383	1.47	No	No	0	8	7
572	E:E:N60	E:E:T63	1.46	No	No	0	3	3
573	R:R:I317	R:R:K321	1.45	No	No	0	5	6
574	R:R:I368	R:R:L372	1.43	No	No	0	4	6
575	R:R:K333	R:R:L320	1.41	No	No	0	8	7
576	E:E:D82	E:E:I79	1.4	No	No	0	6	7
577	R:R:K333	R:R:N329	1.4	No	No	0	8	5
578	E:E:D85	E:E:M88	1.39	No	No	0	7	5
579	E:E:D77	E:E:K73	1.38	No	No	0	4	5
580	R:R:L306	R:R:L310	1.38	No	No	0	5	5
581	R:R:L309	R:R:L310	1.38	Yes	No	0	9	5
582	R:R:L351	R:R:L372	1.38	No	No	0	5	6
583	E:E:I126	E:E:Q125	1.37	No	No	0	5	5
584	E:E:D74	E:E:N70	1.35	No	No	0	1	2
585	E:E:H127	E:E:I126	1.33	Yes	No	0	8	5
586	E:E:L133	R:R:Q50	1.33	No	Yes	0	4	4
587	R:R:D106	R:R:Q107	1.31	Yes	No	0	5	3
588	R:R:F246	R:R:V245	1.31	No	No	0	6	7
589	E:E:D144	E:E:E143	1.3	No	No	0	7	7
590	L:L:F33	L:L:T34	1.3	Yes	No	0	0	0
591	E:E:R91	E:E:T95	1.29	No	No	0	6	2
592	R:R:K333	R:R:R336	1.24	No	No	0	8	8
593	E:E:F107	E:E:L106	1.22	Yes	No	0	5	1
594	E:E:F107	E:E:L109	1.22	Yes	No	0	5	7
595	E:E:D108	R:R:R119	1.19	No	Yes	0	3	4
596	R:R:N400	R:R:W399	1.13	No	No	0	4	5
597	R:R:F166	R:R:Y165	1.03	Yes	No	0	7	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	E:E:Y72	8.39	6	3	9
2	E:E:M76	6.8625	4	3	9
3	E:E:W86	10.97	6	3	9
4	E:E:I89	6.2525	4	0	8
5	E:E:Y93	12.9375	4	3	9
6	E:E:H102	4.2925	4	10	1
7	E:E:F103	5.0025	4	0	1
8	E:E:F107	3.88	4	9	5
9	E:E:H127	5.68857	7	3	8
10	E:E:F128	14.708	5	3	9
11	E:E:L146	3.315	6	1	8
12	E:E:M149	3.25	4	1	9
13	E:E:I150	3.7625	4	0	9
14	E:E:I151	2.5725	4	0	6
15	E:E:I154	3.2	4	2	9
16	E:E:I157	3.096	5	2	9
17	E:E:L160	3.8225	4	2	9
18	L:L:F14	7.3075	4	1	0
19	L:L:Q24	4.91	5	1	0
20	L:L:Y31	8.646	5	1	0
21	L:L:Q32	7.108	5	1	0
22	L:L:F33	6.40429	7	1	0
23	L:L:D37	7.225	4	0	0
24	L:L:K46	5.4	5	1	0
25	L:L:I47	7.276	5	1	0
26	L:L:Y52	15.032	5	1	0
27	R:R:I41	6.46	4	1	6
28	R:R:M42	6.322	5	3	3
29	R:R:Q45	5.2275	4	0	5
30	R:R:Y49	18.094	5	3	3
31	R:R:Q50	3.65	4	0	4
32	R:R:Y64	5.602	5	8	3
33	R:R:R67	8.51	4	0	4
34	R:R:T68	5.9225	4	1	5
35	R:R:W69	4.1325	4	0	7
36	R:R:W72	14.7775	4	1	5
37	R:R:W75	9.65286	7	1	9
38	R:R:D77	8.5725	4	8	4
39	R:R:C88	4.33	4	1	9
40	R:R:Y91	16.0225	4	1	5
41	R:R:F92	10.004	5	1	6
42	R:R:F95	9.784	5	1	5
43	R:R:D96	7.925	6	1	5
44	R:R:P97	7.67	4	1	3
45	R:R:E99	5.55333	6	1	5
46	R:R:D106	6.165	4	0	5
47	R:R:W111	10.3733	6	1	9
48	R:R:H114	10.195	4	7	4
49	R:R:R119	4.16	4	1	4
50	R:R:Y124	11.242	5	1	4
51	R:R:C127	4.4825	4	1	9
52	R:R:N128	4.146	5	1	3
53	R:R:N130	8.72	4	1	2
54	R:R:K134	8.978	5	1	3
55	R:R:F142	4.725	4	6	6
56	R:R:H149	4.28	5	5	7
57	R:R:I153	4.2975	4	5	6
58	R:R:L156	4.83333	6	4	9
59	R:R:S159	5.5525	4	4	8
60	R:R:L160	3.7525	4	4	5
61	R:R:F163	4.2125	4	4	7
62	R:R:F166	3.674	5	0	7
63	R:R:Q172	5.1725	4	0	7
64	R:R:I174	4.0525	4	4	9
65	R:R:L176	3.448	5	2	9
66	R:R:H177	6.6625	4	2	9
67	R:R:K178	6.395	4	4	6
68	R:R:F181	5.90833	6	4	8
69	R:R:F184	7.31833	6	4	8
70	R:R:A199	1.6525	4	6	4
71	R:R:L204	4.475	4	1	4
72	R:R:C212	4.8325	4	1	9
73	R:R:K213	6.362	5	1	8
74	R:R:Q216	6.4225	4	1	6
75	R:R:F217	3.7225	4	0	6
76	R:R:H219	4.718	5	1	6
77	R:R:L220	6.166	5	1	7
78	R:R:Y221	6.8575	4	2	8
79	R:R:Y227	7.672	5	4	8
80	R:R:F228	4.48333	6	2	5
81	R:R:W229	9.66333	6	2	9
82	R:R:M230	4.3625	4	4	9
83	R:R:L231	3.50833	6	2	8
84	R:R:I235	4.6275	4	0	6
85	R:R:Y236	7.925	4	2	8
86	R:R:H238	11.255	4	11	8
87	R:R:L252	3.3075	4	2	6
88	R:R:Y255	4.48833	6	2	8
89	R:R:L258	3.278	5	2	6
90	R:R:W260	7.326	5	2	9
91	R:R:F262	4.30143	7	2	4
92	R:R:P263	4.2	5	2	9
93	R:R:H270	6.866	5	1	8
94	R:R:R274	11.522	5	1	7
95	R:R:Y277	8.734	5	1	3
96	R:R:Y278	9.96143	7	1	6
97	R:R:W283	14.3325	4	0	8
98	R:R:S285	5.7575	4	1	5
99	R:R:L290	6.70667	6	1	3
100	R:R:Y292	5.805	4	0	6
101	R:R:H295	7.12	4	0	6
102	R:R:P297	4.89	4	0	8
103	R:R:L309	3.165	4	0	9
104	R:R:N311	7.1975	4	11	7
105	R:R:L344	5.896	5	2	9
106	R:R:L345	3.215	4	0	9
107	R:R:I347	3.7025	4	12	7
108	R:R:M369	3.49	4	5	8
109	R:R:H370	6.898	5	5	7
110	R:R:M373	7.9325	4	0	7
111	R:R:H374	11.3425	4	5	9
112	R:R:S381	4.515	4	4	8
113	R:R:C385	4.5325	4	0	9
114	R:R:F386	4.494	5	4	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	E:E:L109	E:E:N113	11.756	4.12	No	No	0	7	9
2	E:E:G110	E:E:N113	12.8171	5.09	No	No	0	5	9
3	E:E:G110	R:R:R119	13.3471	4.5	No	Yes	0	5	4
4	L:L:K46	R:R:R119	14.4019	4.95	Yes	Yes	1	0	4
5	L:L:K46	L:L:Y52	17.5759	11.94	Yes	Yes	1	0	0
6	L:L:Y52	R:R:G71	20.7864	5.79	Yes	No	1	0	4
7	R:R:G71	R:R:W69	20.5728	2.81	No	Yes	0	4	7
8	E:E:I120	R:R:W69	19.9777	2.35	No	Yes	0	9	7
9	E:E:I120	R:R:Y49	24.8807	4.84	No	Yes	0	9	3
10	E:E:H127	R:R:Y49	20.5726	3.27	Yes	Yes	3	8	3
11	E:E:W86	E:E:Y93	13.7325	8.68	Yes	Yes	3	9	9
12	E:E:Y93	R:R:Q45	26.2427	7.89	Yes	Yes	0	9	5
13	L:L:Y52	R:R:W72	18.8135	29.9	Yes	Yes	1	0	5
14	R:R:I41	R:R:W72	36.2601	5.87	Yes	Yes	1	6	5
15	R:R:I41	R:R:Q45	35.9062	2.74	Yes	Yes	0	6	5
16	R:R:F95	R:R:W72	54.8418	5.01	Yes	Yes	1	5	5
17	R:R:C127	R:R:F95	89.1236	4.19	Yes	Yes	1	9	5
18	R:R:C127	R:R:E99	93.2495	3.04	Yes	Yes	1	9	5
19	R:R:D96	R:R:E99	98.6712	2.6	Yes	Yes	1	5	5
20	L:L:F33	R:R:D96	49.6152	2.39	Yes	Yes	1	0	5
21	L:L:F33	L:L:Q32	50.5615	12.88	Yes	Yes	1	0	0
22	L:L:Q32	L:L:Y31	100	2.25	Yes	Yes	1	0	0
23	L:L:Y31	R:R:S285	44.15	2.54	Yes	Yes	1	0	5
24	R:R:S285	R:R:Y278	43.8556	7.63	Yes	Yes	1	5	6
25	L:L:Y52	R:R:Y124	19.8133	14.89	Yes	Yes	1	0	4
26	R:R:F95	R:R:Y124	30.8319	14.44	Yes	Yes	1	5	4
27	R:R:D96	R:R:P97	49.2931	6.44	Yes	Yes	1	5	3
28	L:L:Q32	R:R:P97	49.3414	12.63	Yes	Yes	1	0	3
29	E:E:L146	R:R:L290	20.0604	2.77	Yes	Yes	1	8	3
30	R:R:L290	R:R:R274	19.814	7.29	Yes	Yes	1	3	7
31	R:R:R274	R:R:Y278	24.0188	10.29	Yes	Yes	1	7	6
32	R:R:L290	R:R:T288	19.5947	13.27	Yes	No	1	3	5
33	R:R:T288	R:R:Y278	19.6583	7.49	No	Yes	1	5	6
34	E:E:I150	E:E:L146	18.1992	2.85	Yes	Yes	0	9	8
35	E:E:I150	R:R:I293	17.7027	5.89	Yes	No	0	9	8
36	R:R:I293	R:R:L290	18.2048	2.85	No	Yes	0	8	3
37	R:R:L291	R:R:S286	55.5546	3	No	No	0	5	7
38	L:L:H28	R:R:S286	55.6853	6.97	No	No	0	0	7
39	L:L:H28	L:L:Y31	55.685	8.71	No	Yes	1	0	0
40	E:E:I150	E:E:I151	44.2192	1.47	Yes	Yes	0	9	6
41	E:E:I151	E:E:I154	42.3897	1.47	Yes	Yes	0	6	9
42	E:E:I154	R:R:P297	18.3765	6.77	Yes	Yes	0	9	8
43	E:E:I154	E:E:I157	22.7502	2.94	Yes	Yes	2	9	9
44	L:L:Q24	R:R:H219	33.9329	6.18	Yes	Yes	1	0	6
45	L:L:Q24	R:R:L291	45.9908	2.66	Yes	No	0	0	5
46	E:E:I157	R:R:F228	15.758	5.02	Yes	Yes	2	9	5
47	R:R:F228	R:R:P297	15.8185	2.89	Yes	Yes	0	5	8
48	R:R:H219	R:R:N187	24.2704	2.55	Yes	No	0	6	8
49	R:R:N187	R:R:N226	24.15	5.45	No	No	0	8	8
50	R:R:N226	R:R:S183	13.2577	5.96	No	No	0	8	8
51	R:R:S183	R:R:W229	12.3228	3.71	No	Yes	2	8	9
52	R:R:I235	R:R:L231	24.9779	5.71	Yes	Yes	0	6	8
53	R:R:F228	R:R:L231	30.9669	2.44	Yes	Yes	2	5	8
54	R:R:L176	R:R:W229	11.7764	2.28	Yes	Yes	2	9	9
55	R:R:F184	R:R:N226	12.309	18.12	Yes	No	0	8	8
56	R:R:F308	R:R:I235	20.2447	5.02	No	Yes	0	8	6
57	R:R:F308	R:R:H238	13.4983	18.1	No	Yes	0	8	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
E:E:G110	R:R:R119	4.5	0	No	Yes	5	4	2	1
E:E:I150	E:E:L146	2.85	0	Yes	Yes	9	8	2	2
E:E:L146	R:R:H289	3.86	1	Yes	No	8	4	2	1
E:E:I150	R:R:Y292	4.84	0	Yes	Yes	9	6	2	1
L:L:F14	R:R:H289	13.58	1	Yes	No	0	4	0	1
L:L:F14	R:R:Y292	5.16	1	Yes	Yes	0	6	0	1
L:L:G15	R:R:H289	3.18	1	No	No	0	4	0	1
L:L:C16	R:R:L291	3.17	0	No	No	0	5	0	1
L:L:C16	R:R:Y292	8.06	0	No	Yes	0	6	0	1
L:L:F18	R:R:Y292	5.16	0	No	Yes	0	6	0	1
L:L:F18	R:R:C299	9.78	0	No	No	0	4	0	1
L:L:T20	R:R:Y227	4.99	4	No	Yes	0	8	0	1
L:L:T20	R:R:H295	9.58	4	No	Yes	0	6	0	1
L:L:T20	R:R:I298	3.04	4	No	No	0	7	0	1
L:L:C21	R:R:H295	8.85	0	No	Yes	0	6	0	1
L:L:T22	R:R:H370	9.58	0	No	Yes	0	7	0	1
L:L:T22	R:R:M373	3.01	0	No	Yes	0	7	0	1
L:L:V23	R:R:M223	4.56	0	No	No	0	6	0	1
L:L:Q24	R:R:H219	6.18	1	Yes	Yes	0	6	0	1
L:L:Q24	R:R:L220	3.99	1	Yes	Yes	0	7	0	1
L:L:Q24	R:R:L291	2.66	1	Yes	No	0	5	0	1
L:L:Q24	R:R:H295	7.42	1	Yes	Yes	0	6	0	1
L:L:K25	R:R:S286	3.06	0	No	No	0	7	0	1
L:L:H28	R:R:S285	6.97	1	No	Yes	0	5	0	1
L:L:H28	R:R:S286	6.97	1	No	No	0	7	0	1
L:L:Y31	R:R:Q202	6.76	1	Yes	No	0	2	0	1
L:L:Y31	R:R:I284	22.97	1	Yes	No	0	6	0	1
L:L:Y31	R:R:S285	2.54	1	Yes	Yes	0	5	0	1
L:L:Q32	R:R:D90	5.22	1	Yes	No	0	3	0	1
L:L:Q32	R:R:P97	12.63	1	Yes	Yes	0	3	0	1
L:L:F33	R:R:D96	2.39	1	Yes	Yes	0	5	0	1
L:L:F33	R:R:T131	2.59	1	Yes	No	0	1	0	1
L:L:F33	R:R:K134	12.41	1	Yes	Yes	0	3	0	1
L:L:F33	R:R:V135	10.49	1	Yes	No	0	1	0	1
L:L:F33	R:R:A138	2.77	1	Yes	No	0	5	0	1
L:L:T34	R:R:N200	4.39	0	No	No	0	3	0	1
L:L:D37	R:R:V36	10.22	0	Yes	No	0	2	0	1
L:L:D37	R:R:T37	13.01	0	Yes	No	0	4	0	1
L:L:K38	R:R:Q93	10.85	0	No	No	0	4	0	1
L:L:D39	R:R:F92	3.58	0	No	Yes	0	6	0	1
L:L:N40	R:R:Q93	5.28	0	No	No	0	4	0	1
L:L:N40	R:R:D94	16.16	0	No	No	0	5	0	1
L:L:A42	R:R:F92	2.77	1	No	Yes	0	6	0	1
L:L:A42	R:R:F95	2.77	1	No	Yes	0	5	0	1
L:L:A42	R:R:Y124	4	1	No	Yes	0	4	0	1
L:L:K46	R:R:R119	4.95	1	Yes	Yes	0	4	0	1
L:L:I47	R:R:Y124	20.55	1	Yes	Yes	0	4	0	1
L:L:I47	R:R:T125	4.56	1	Yes	No	0	6	0	1
L:L:I47	R:R:N128	5.66	1	Yes	Yes	0	3	0	1
L:L:P49	R:R:H114	18.3	7	No	Yes	0	4	0	1
L:L:P49	R:R:W121	13.51	7	No	No	0	8	0	1
L:L:Q50	R:R:S117	8.66	0	No	No	0	4	0	1
L:L:G51	R:R:R119	6	1	No	Yes	0	4	0	1
L:L:Y52	R:R:D70	12.64	1	Yes	No	0	9	0	1
L:L:Y52	R:R:G71	5.79	1	Yes	No	0	4	0	1
L:L:Y52	R:R:W72	29.9	1	Yes	Yes	0	5	0	1
L:L:Y52	R:R:Y124	14.89	1	Yes	Yes	0	4	0	1
R:R:K40	R:R:V36	4.55	0	No	No	5	2	2	1
R:R:T37	R:R:Y91	18.73	1	No	Yes	4	5	1	2
R:R:F92	R:R:T37	2.59	1	Yes	No	6	4	1	1
R:R:I41	R:R:W72	5.87	1	Yes	Yes	6	5	2	1
R:R:I41	R:R:Y91	8.46	1	Yes	Yes	6	5	2	2
R:R:G71	R:R:W69	2.81	1	No	Yes	4	7	1	2
R:R:D70	R:R:G71	3.35	1	No	No	9	4	1	1
R:R:D70	R:R:W111	3.35	1	No	Yes	9	9	1	2
R:R:W72	R:R:Y91	18.33	1	Yes	Yes	5	5	1	2
R:R:F95	R:R:W72	5.01	1	Yes	Yes	5	5	1	1
R:R:D90	R:R:P97	8.05	1	No	Yes	3	3	1	1
R:R:F92	R:R:Y91	18.57	1	Yes	Yes	6	5	1	2
R:R:F92	R:R:F95	22.51	1	Yes	Yes	6	5	1	1
R:R:D94	R:R:N128	5.39	0	No	Yes	5	3	1	1
R:R:F95	R:R:Y124	14.44	1	Yes	Yes	5	4	1	1
R:R:C127	R:R:F95	4.19	1	Yes	Yes	9	5	2	1
R:R:D96	R:R:P97	6.44	1	Yes	Yes	5	3	1	1
R:R:D96	R:R:E99	2.6	1	Yes	Yes	5	5	1	2
R:R:D96	R:R:N130	12.12	1	Yes	Yes	5	2	1	2
R:R:D96	R:R:T131	11.56	1	Yes	No	5	1	1	1
R:R:D96	R:R:K134	12.44	1	Yes	Yes	5	3	1	1
R:R:P97	R:R:S98	3.56	1	Yes	No	3	3	1	2
R:R:K134	R:R:S98	7.65	1	Yes	No	3	3	1	2
R:R:C127	R:R:E99	3.04	1	Yes	Yes	9	5	2	2
R:R:E99	R:R:N130	9.2	1	Yes	Yes	5	2	2	2
R:R:H114	R:R:P115	4.58	7	Yes	No	4	3	1	2
R:R:A116	R:R:H114	7.32	0	No	Yes	3	4	2	1
R:R:H114	R:R:W121	10.58	7	Yes	No	4	8	1	1
R:R:P115	R:R:W121	4.05	7	No	No	3	8	2	1
R:R:N123	R:R:T125	11.7	0	No	No	8	6	2	1
R:R:N128	R:R:Y124	2.33	1	Yes	Yes	3	4	1	1
R:R:N128	R:R:T125	2.92	1	Yes	No	3	6	1	1
R:R:N128	R:R:V129	4.43	1	Yes	No	3	2	1	2
R:R:E133	R:R:N130	6.57	1	No	Yes	1	2	2	2
R:R:K134	R:R:N130	6.99	1	Yes	Yes	3	2	1	2
R:R:E133	R:R:K134	5.4	1	No	Yes	1	3	2	1
R:R:K136	R:R:V135	6.07	0	No	No	2	1	2	1
R:R:H370	R:R:L141	3.86	5	Yes	No	7	6	1	2
R:R:F142	R:R:L195	4.87	6	Yes	No	6	7	2	1
R:R:H149	R:R:T145	2.74	5	Yes	No	7	7	2	1
R:R:H374	R:R:T145	17.8	5	Yes	No	9	7	2	1
R:R:H149	R:R:T191	6.85	5	Yes	No	7	7	2	2
R:R:H149	R:R:H374	3.58	5	Yes	Yes	7	9	2	2
R:R:H219	R:R:N187	2.55	1	Yes	No	6	8	1	2
R:R:H219	R:R:V190	4.15	1	Yes	No	6	6	1	2
R:R:H219	R:R:T191	6.85	1	Yes	No	6	7	1	2
R:R:Q202	R:R:V205	8.6	0	No	No	2	4	1	2
R:R:I284	R:R:V205	3.07	0	No	No	6	4	1	2
R:R:L220	R:R:Q216	7.99	1	Yes	Yes	7	6	1	2
R:R:H270	R:R:Q216	7.42	1	Yes	Yes	8	6	2	2
R:R:H219	R:R:L220	3.86	1	Yes	Yes	6	7	1	1
R:R:H270	R:R:L220	6.43	1	Yes	Yes	8	7	2	1
R:R:I294	R:R:L220	8.56	1	No	Yes	7	7	2	1
R:R:M223	R:R:Y227	4.79	0	No	Yes	6	8	1	1
R:R:H295	R:R:M223	2.63	0	Yes	No	6	6	1	1
R:R:G224	R:R:I298	3.53	0	No	No	5	7	2	1
R:R:M230	R:R:Y227	4.79	4	Yes	Yes	9	8	2	1
R:R:I298	R:R:Y227	14.51	4	No	Yes	7	8	1	1
R:R:F349	R:R:Y227	9.28	0	No	Yes	8	8	2	1
R:R:H270	R:R:I294	6.63	1	Yes	No	8	7	2	2
R:R:S285	R:R:Y278	7.63	1	Yes	Yes	5	6	1	2
R:R:D287	R:R:Y278	12.64	1	No	Yes	3	6	2	2
R:R:D287	R:R:S285	5.89	1	No	Yes	3	5	2	1
R:R:L291	R:R:S286	3	0	No	No	5	7	1	1
R:R:F349	R:R:M373	9.95	0	No	Yes	8	7	2	1
R:R:D366	R:R:M369	2.77	5	No	Yes	6	8	2	2
R:R:D366	R:R:H370	7.56	5	No	Yes	6	7	2	1
R:R:H370	R:R:M369	3.94	5	Yes	Yes	7	8	1	2
R:R:M369	R:R:M373	4.33	5	Yes	Yes	8	7	2	1
R:R:H370	R:R:H374	9.55	5	Yes	Yes	7	9	1	2
R:R:H374	R:R:M373	14.44	5	Yes	Yes	9	7	2	1
L:L:A27	R:R:A199	1.79	6	No	Yes	0	4	0	1
L:L:D37	R:R:G35	1.68	0	Yes	No	0	2	0	1
L:L:I30	R:R:A199	1.62	0	No	Yes	0	4	0	1
R:R:A199	R:R:I284	1.62	6	Yes	No	4	6	1	1
L:L:A27	R:R:L195	1.58	6	No	No	0	7	0	1
R:R:A199	R:R:L195	1.58	6	Yes	No	4	7	1	1
R:R:L139	R:R:V135	1.49	0	No	No	3	1	2	1
L:L:L26	R:R:T145	1.47	0	No	No	0	7	0	1
E:E:D108	R:R:R119	1.19	0	No	Yes	3	4	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	6UUN_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.25
Number of Linked Nodes	471
Number of Links	597
Number of Hubs	114
Number of Links mediated by Hubs	403
Number of Communities	12
Number of Nodes involved in Communities	164
Number of Links involved in Communities	238

Path Summary
Number Of Nodes in MetaPath	58
Number Of Links MetaPath	57
Number of Shortest Paths	737414
Length Of Smallest Path	3
Average Path Length	23.5381
Length of Longest Path	39
Minimum Path Strength	1.22
Average Path Strength	5.99556
Maximum Path Strength	33.26
Minimum Path Correlation	0.7
Average Path Correlation	0.967871
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	4
Average % Of Corr. Nodes	47.962
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	67.8123
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • molecular function activator activity • phosphorus-oxygen lyase activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • adenylate cyclase activator activity • adenylate cyclase activity • cation binding • metal ion binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • biological regulation • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of biological process • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • protein localization • regulation of localization • establishment of protein localization • nitrogen compound transport • localization • cellular macromolecule localization • regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • protein transport • regulation of cellular localization • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • molecular transducer activity • coreceptor activity • signaling receptor activity • calcitonin family binding • amide binding • adrenomedullin binding • peptide hormone binding • hormone binding • calcitonin family receptor activity • peptide receptor activity • adrenomedullin receptor activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • transmembrane signaling receptor activity • heart development • circulatory system development • circulatory system process • regulation of blood pressure • regulation of biological quality • blood circulation • localization • import into cell • receptor internalization • transport • receptor-mediated endocytosis • endocytosis • establishment of localization • vesicle-mediated transport • blood vessel morphogenesis • tube development • angiogenesis • vasculature development • anatomical structure morphogenesis • tube morphogenesis • anatomical structure formation involved in morphogenesis • blood vessel development • regulation of biosynthetic process • positive regulation of biological process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • positive regulation of macromolecule biosynthetic process • regulation of gene expression • positive regulation of metabolic process • biosynthetic process • positive regulation of gene expression • positive regulation of biosynthetic process • regulation of macromolecule biosynthetic process • metabolic process • positive regulation of macromolecule metabolic process • macromolecule metabolic process • regulation of metabolic process • positive regulation of cellular process • regulation of developmental process • cellular developmental process • regulation of vasculogenesis • regulation of cell differentiation • vasculogenesis • positive regulation of developmental process • positive regulation of cell differentiation • cell differentiation • positive regulation of vasculogenesis • protein localization • establishment of protein localization • cellular localization • nitrogen compound transport • protein transport • cellular macromolecule localization • macromolecule localization • smooth muscle cell differentiation • cell development • muscle cell differentiation • muscle structure development • vascular associated smooth muscle cell differentiation • muscle cell development • vascular associated smooth muscle cell development • protein localization to cell periphery • protein localization to plasma membrane • localization within membrane • protein localization to membrane • sprouting angiogenesis • negative regulation of vascular permeability • regulation of vascular permeability • vascular process in circulatory system • bicellular tight junction assembly • tight junction organization • apical junction assembly • cellular component organization • cellular component biogenesis • cell junction organization • cellular component assembly • cell junction assembly • tight junction assembly • cellular component organization or biogenesis • cell-cell junction assembly • cell-cell junction organization • intracellular transport • establishment of localization in cell • intracellular protein transport • regulation of signaling • regulation of signal transduction • regulation of response to stimulus • regulation of cell communication • regulation of G protein-coupled receptor signaling pathway • adrenomedullin receptor signaling pathway • calcitonin family receptor signaling pathway • regulation of vasculature development • regulation of multicellular organismal process • regulation of anatomical structure morphogenesis • regulation of multicellular organismal development • positive regulation of angiogenesis • positive regulation of vasculature development • regulation of angiogenesis • positive regulation of multicellular organismal process • extracellular matrix organization • basement membrane assembly • extracellular matrix assembly • basement membrane organization • extracellular structure organization • external encapsulating structure organization • amylin receptor signaling pathway • amylin receptor 2 signaling pathway • monoatomic ion transport • monoatomic cation transport • calcium ion transport • metal ion transport • negative regulation of endothelial cell apoptotic process • negative regulation of programmed cell death • regulation of apoptotic process • negative regulation of biological process • regulation of programmed cell death • cell death • negative regulation of apoptotic process • negative regulation of cellular process • endothelial cell apoptotic process • apoptotic process • programmed cell death • regulation of endothelial cell apoptotic process • adherens junction organization • adherens junction assembly • cellular response to growth factor stimulus • cellular response to vascular endothelial growth factor stimulus • response to growth factor • clathrin-coated pit • cell surface • receptor complex • G protein-coupled receptor dimeric complex • adrenomedullin receptor complex • plasma membrane signaling receptor complex • G protein-coupled receptor complex • calcitonin family receptor complex • G-protein beta-subunit binding • fibroblast proliferation • signaling receptor binding • adrenomedullin receptor binding • G protein-coupled receptor binding • molecular function activator activity • signaling receptor activator activity • hormone activity • molecular function regulator activity • signaling receptor regulator activity • receptor ligand activity • regulation of body fluid levels • renal system process • regulation of urine volume • heart process • regulation of heart contraction • regulation of system process • positive regulation of heart rate • positive regulation of blood circulation • positive regulation of heart contraction • regulation of blood circulation • heart contraction • regulation of heart rate • positive regulation of cytosolic calcium ion concentration • regulation of tube diameter • regulation of tube size • negative regulation of vasoconstriction • regulation of vasoconstriction • blood vessel diameter maintenance • negative regulation of multicellular organismal process • vasoconstriction • regulation of anatomical structure size • regulation of the force of heart contraction • multi-multicellular organism process • reproductive process • female pregnancy • multi-organism reproductive process • regulation of hormone levels • steroid metabolic process • androgen metabolic process • primary metabolic process • hormone metabolic process • lipid metabolic process • odontogenesis of dentin-containing tooth • odontogenesis • animal organ morphogenesis • positive regulation of programmed cell death • positive regulation of apoptotic process • chordate embryonic development • labyrinthine layer development • embryo development • embryonic placenta development • embryo development ending in birth or egg hatching • embryonic organ development • epithelium development • placenta development • embryonic morphogenesis • morphogenesis of an epithelium • branching involved in labyrinthine layer morphogenesis • tissue development • in utero embryonic development • embryonic placenta morphogenesis • labyrinthine layer morphogenesis • tissue morphogenesis • morphogenesis of a branching structure • morphogenesis of a branching epithelium • developmental growth • growth • response to corticosteroid • response to steroid hormone • response to glucocorticoid • embryonic epithelial tube formation • tube formation • epithelial tube formation • primary neural tube formation • epithelial tube morphogenesis • morphogenesis of embryonic epithelium • neural tube development • nervous system development • neural tube closure • neural tube formation • tube closure • positive regulation of cell population proliferation • regulation of cell population proliferation • negative regulation of cell population proliferation • response to peptide hormone • response to insulin • positive regulation of progesterone biosynthetic process • regulation of hormone biosynthetic process • regulation of lipid metabolic process • regulation of primary metabolic process • regulation of small molecule metabolic process • positive regulation of lipid metabolic process • small molecule metabolic process • hormone biosynthetic process • olefinic compound biosynthetic process • C21-steroid hormone biosynthetic process • regulation of progesterone biosynthetic process • regulation of ketone metabolic process • positive regulation of steroid biosynthetic process • positive regulation of hormone biosynthetic process • regulation of steroid biosynthetic process • ketone metabolic process • regulation of hormone metabolic process • lipid biosynthetic process • C21-steroid hormone metabolic process • progesterone metabolic process • steroid biosynthetic process • steroid hormone biosynthetic process • small molecule biosynthetic process • positive regulation of hormone metabolic process • progesterone biosynthetic process • regulation of ketone biosynthetic process • regulation of steroid metabolic process • positive regulation of lipid biosynthetic process • positive regulation of steroid metabolic process • olefinic compound metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • ketone biosynthetic process • response to decreased oxygen levels • response to hypoxia • response to stress • response to oxygen levels • response to abiotic stimulus • regulation of systemic arterial blood pressure • cellular response to xenobiotic stimulus • response to xenobiotic stimulus • defense response • inflammatory response • animal organ regeneration • regeneration • biological process involved in interspecies interaction between organisms • response to other organism • response to external stimulus • response to lipopolysaccharide • response to biotic stimulus • response to bacterium • response to external biotic stimulus • response to molecule of bacterial origin • negative adaptation of signaling pathway • negative regulation of signaling • desensitization of G protein-coupled receptor signaling pathway • negative regulation of G protein-coupled receptor signaling pathway • negative regulation of cell communication • G protein-coupled receptor internalization • negative regulation of response to stimulus • negative regulation of signal transduction • adaptation of signaling pathway • cell projection organization • neuron projection development • neuron projection regeneration • neurogenesis • neuron differentiation • cellular response to stress • plasma membrane bounded cell projection organization • generation of neurons • neuron development • response to nutrient levels • response to starvation • response to ether • vesicle lumen • intracellular vesicle • membrane-enclosed lumen • cytoplasmic vesicle lumen • secretory granule lumen • intracellular organelle lumen • cytoplasmic vesicle • organelle lumen • secretory granule • secretory vesicle • calcitonin receptor activity • calcitonin gene-related peptide receptor activity • regulation of vascular associated smooth muscle cell proliferation • positive regulation of vascular associated smooth muscle cell proliferation • regulation of smooth muscle cell proliferation • smooth muscle cell proliferation • positive regulation of smooth muscle cell proliferation • muscle cell proliferation • vascular associated smooth muscle cell proliferation • cell surface receptor signaling pathway • calcitonin gene-related peptide receptor signaling pathway • response to disaccharide • cellular response to sucrose stimulus • cellular response to carbohydrate stimulus • response to carbohydrate • response to sucrose • cellular response to disaccharide stimulus • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • endosome • CGRP receptor complex • endoplasmic reticulum
SCOP2	Domain Identifier	• RAMP1-like • Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like • FnI-like domain
SCOP2	Family Identifier	• RAMP1-like • Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like • FnI-like domain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	E
Protein	RAMP2
UniProt	O60895
Sequence	>6UUN_nogp_Chain_E N Y E T A V Q F C W N H Y K D Q M D P I E K D W C D W A M I S R P Y S T L R D C L E H F A E L F D L G F P N P L A E R I I F E T H Q I H F A N C S L V Q P T F S D P P E D V L L A M I I A P I C L I P F L I T L V V W R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	R
Protein	Receptor
UniProt	Q16602
Sequence	>6UUN_nogp_Chain_R G V T R N K I M T A Q Y E C Y Q K I M Q D P I Q Q A E G V Y C N R T W D G W L C W N D V A A G T E S M Q L C P D Y F Q D F D P S E K V T K I C D Q D G N W F R H P A S N R T W T N Y T Q C N V N T H E K V K T A L N L F Y L T I I G H G L S I A S L L I S L G I F F Y F K S L S C Q R I T L H K N L F F S F V C N S V V T I I H L T A V A N N Q A L V A T N P V S C K V S Q F I H L Y L M G C N Y F W M L C E G I Y L H T L I V V A V F A E K Q H L M W Y Y F L G W G F P L I P A C I H A I A R S L Y Y N D N C W I S S D T H L L Y I I H G P I C A A L L V N L F F L L N I V R V L I T K L K V T N L Y M K A V R A T L I L V P L L G I E F V L I P E V Y D Y I M H I L M H F Q G L L V S T I F C F F N G E V Q A I L R R N W N Q Y Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6UUN	B1	Peptide	Calcitonin	CT Like (AM1)	Homo sapiens	Adrenomedullin	-	Gs/β1/γ2; RAMP2	3	2020-03-25	10.1021/acsptsci.9b00080
	6UUN (No Gprot)	B1	Peptide	Calcitonin	CT Like (AM1)	Homo sapiens	Adrenomedullin	-		3	2020-03-25	10.1021/acsptsci.9b00080

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