psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	E:E:L35	E:E:Y32	5.86	No	No	0	2	5
2	E:E:L80	E:E:Y32	4.69	No	No	0	6	5
3	E:E:G33	E:E:M76	5.24	No	No	0	5	4
4	E:E:L36	E:E:M76	8.48	Yes	No	0	5	4
5	E:E:R37	E:E:R91	3.2	No	No	2	3	3
6	E:E:F92	E:E:R37	19.24	Yes	No	2	5	3
7	E:E:C40	E:E:C72	7.28	No	No	11	9	9
8	E:E:L41	E:E:Q45	10.65	Yes	No	2	5	4
9	E:E:F92	E:E:L41	8.53	Yes	Yes	2	5	5
10	E:E:L41	E:E:V96	5.96	Yes	No	2	5	8
11	E:E:L41	E:E:Y100	3.52	Yes	Yes	2	5	8
12	E:E:Q45	E:E:T42	4.25	No	No	0	4	2
13	E:E:Q43	E:E:V46	4.3	No	No	12	1	1
14	E:E:D47	E:E:Q43	13.05	No	No	12	5	1
15	E:E:E68	E:E:Q43	3.82	No	No	0	4	1
16	E:E:F44	E:E:M48	4.98	Yes	No	4	9	9
17	E:E:F44	E:E:Y66	4.13	Yes	No	4	9	9
18	E:E:F44	E:E:L69	18.27	Yes	No	0	9	8
19	E:E:F101	E:E:F44	3.22	No	Yes	4	9	9
20	E:E:Q45	E:E:Y100	5.64	No	Yes	2	4	8
21	E:E:D47	E:E:V46	2.92	No	No	12	5	1
22	E:E:D47	E:E:S65	5.89	No	No	0	5	4
23	E:E:M48	E:E:W56	10.47	No	No	0	9	5
24	E:E:F101	E:E:M48	4.98	No	No	4	9	9
25	E:E:L55	E:E:V51	8.94	No	Yes	0	5	5
26	E:E:T62	E:E:V51	4.76	No	Yes	0	8	5
27	E:E:E53	E:E:W56	6.54	No	No	0	4	5
28	E:E:C104	E:E:C57	7.28	No	No	0	9	9
29	E:E:D58	E:E:S107	7.36	No	No	0	5	6
30	E:E:I63	E:E:W59	5.87	No	Yes	0	5	7
31	E:E:I106	E:E:W59	9.4	No	Yes	0	3	7
32	E:E:W59	R:R:D50	8.93	Yes	No	0	7	2
33	E:E:W59	R:R:Y53	7.72	Yes	No	0	7	1
34	E:E:R61	E:E:R64	3.2	No	No	0	4	5
35	E:E:R61	E:E:S65	3.95	No	No	0	4	4
36	E:E:R64	R:R:K46	3.71	No	No	0	5	4
37	E:E:H97	E:E:Y66	11.98	Yes	No	4	9	9
38	E:E:Y66	R:R:Y53	3.97	No	No	4	9	1
39	E:E:D71	E:E:R67	11.91	No	No	0	3	5
40	E:E:C72	E:E:E68	4.56	No	No	0	9	4
41	E:E:D71	E:E:H75	16.39	No	No	0	3	2
42	E:E:T73	E:E:W84	6.06	Yes	No	0	9	7
43	E:E:T73	E:E:V89	3.17	Yes	No	2	9	8
44	E:E:F93	E:E:T73	5.19	Yes	Yes	2	9	9
45	E:E:E78	E:E:W74	5.45	No	No	0	4	6
46	E:E:W74	E:E:W84	15.93	No	No	0	6	7
47	E:E:W74	R:R:R45	5	No	No	0	6	7
48	E:E:E78	E:E:H75	7.39	No	No	0	4	2
49	E:E:A77	E:E:W84	3.89	No	No	0	8	7
50	E:E:C82	E:E:N86	6.3	No	Yes	0	8	9
51	E:E:F83	R:R:R126	13.9	No	No	0	5	4
52	E:E:E88	E:E:N86	3.94	No	Yes	0	4	9
53	E:E:N86	E:E:V89	4.43	Yes	No	0	9	8
54	E:E:F93	E:E:V89	5.24	Yes	No	2	9	8
55	E:E:D90	R:R:Y56	8.05	No	Yes	0	8	3
56	E:E:F92	E:E:R91	4.28	Yes	No	2	5	3
57	E:E:A95	E:E:R91	4.15	No	No	0	3	3
58	E:E:F92	E:E:F93	7.5	Yes	Yes	2	5	9
59	E:E:F92	E:E:V96	3.93	Yes	No	2	5	8
60	E:E:F93	R:R:Y56	10.32	Yes	Yes	0	9	3
61	E:E:V96	E:E:Y100	5.05	No	Yes	2	8	8
62	E:E:F101	E:E:H97	11.31	No	Yes	4	9	9
63	E:E:H97	R:R:Y53	3.27	Yes	No	4	9	1
64	E:E:H97	R:R:Y56	6.53	Yes	Yes	0	9	3
65	E:E:G98	E:E:R102	6	No	No	4	5	5
66	E:E:G98	R:R:Q60	3.29	No	No	4	5	3
67	E:E:R99	E:E:Y100	15.43	No	Yes	0	4	8
68	E:E:R102	R:R:Q60	16.35	No	No	4	5	3
69	E:E:C104	E:E:P105	3.77	No	No	0	9	7
70	E:E:R109	R:R:N286	9.64	No	No	0	6	7
71	E:E:V111	R:R:F285	3.93	No	Yes	0	5	6
72	E:E:D113	R:R:F285	5.97	No	Yes	3	9	6
73	E:E:D113	R:R:T295	8.67	No	No	3	9	4
74	E:E:P114	R:R:Y284	6.95	No	No	0	9	2
75	E:E:I118	E:E:P115	3.39	No	No	0	7	9
76	E:E:G116	E:E:Y120	7.24	No	No	0	5	5
77	E:E:I118	E:E:S117	4.64	No	No	0	7	4
78	E:E:I123	E:E:L119	4.28	No	No	0	9	8
79	E:E:F122	R:R:I276	3.77	No	No	0	9	5
80	E:E:F122	R:R:T280	9.08	No	No	0	9	4
81	E:E:P126	E:E:V125	3.53	No	No	0	9	6
82	E:E:I127	R:R:P304	5.08	No	Yes	0	8	9
83	E:E:T130	R:R:F269	7.78	No	Yes	0	9	3
84	E:E:T130	R:R:P304	5.25	No	Yes	0	9	9
85	E:E:V133	R:R:F269	10.49	No	Yes	0	8	3
86	E:E:T134	R:R:L238	7.37	No	Yes	0	8	8
87	E:E:L136	E:E:W139	3.42	No	No	0	7	6
88	E:E:V137	R:R:L265	5.96	No	Yes	0	9	7
89	E:E:V138	R:R:I242	4.61	No	Yes	0	9	7
90	E:E:Q140	E:E:W139	13.14	No	No	13	8	6
91	E:E:R143	E:E:W139	10	No	No	13	7	6
92	E:E:Q140	E:E:R143	12.85	No	No	13	8	7
93	E:E:Q140	R:R:W261	14.24	No	Yes	0	8	2
94	E:E:S141	R:R:T246	3.2	No	No	0	9	7
95	E:E:S141	R:R:Y262	7.63	No	Yes	0	9	7
96	E:E:K142	R:R:V250	4.55	No	No	0	9	5
97	E:E:R143	R:R:R258	9.6	No	No	0	7	5
98	E:E:T144	R:R:R258	3.88	No	No	0	7	5
99	H:H:?1	R:R:H121	5.77	Yes	Yes	1	0	4
100	H:H:?1	R:R:W128	10.22	Yes	Yes	1	0	5
101	H:H:?1	R:R:N130	30.8	Yes	Yes	1	0	8
102	H:H:?1	R:R:T132	9.26	Yes	No	1	0	6
103	H:H:?1	R:R:M133	3.81	Yes	No	0	0	5
104	L:L:K1	L:L:N3	6.99	No	No	0	0	0
105	L:L:K1	L:L:R11	4.95	No	No	0	0	0
106	L:L:K1	R:R:E294	5.4	No	No	0	0	3
107	L:L:C2	L:L:C7	7.28	No	No	5	0	0
108	L:L:C2	R:R:Y299	4.03	No	No	0	0	7
109	L:L:C2	R:R:H302	4.42	No	Yes	5	0	6
110	L:L:N3	R:R:W361	7.91	No	No	0	0	4
111	L:L:T4	L:L:T6	3.14	No	No	0	0	0
112	L:L:C7	L:L:T4	3.38	No	No	0	0	0
113	L:L:T4	R:R:Y299	7.49	No	No	0	0	7
114	L:L:A5	R:R:F356	4.16	No	Yes	0	0	7
115	L:L:T6	R:R:Y234	6.24	No	Yes	0	0	7
116	L:L:T6	R:R:H302	6.85	No	Yes	0	0	6
117	L:L:C7	R:R:H302	7.37	No	Yes	5	0	6
118	L:L:Q10	R:R:H226	7.42	No	No	0	0	6
119	L:L:Q10	R:R:Q227	3.84	No	Yes	0	0	7
120	L:L:R11	R:R:V293	3.92	No	No	0	0	6
121	L:L:L12	R:R:H377	7.71	No	Yes	0	0	7
122	L:L:A13	R:R:H201	2.93	No	No	0	0	6
123	L:L:E14	L:L:R17	11.63	No	No	15	0	0
124	L:L:E14	R:R:L291	5.3	No	Yes	15	0	6
125	L:L:E14	R:R:V293	4.28	No	No	0	0	6
126	L:L:F15	L:L:S19	9.25	Yes	No	0	0	0
127	L:L:F15	R:R:K141	11.17	Yes	No	0	0	3
128	L:L:F15	R:R:L142	4.87	Yes	No	0	0	2
129	L:L:L16	R:R:Y149	3.52	No	Yes	0	0	5
130	L:L:L16	R:R:V206	4.47	No	No	0	0	3
131	L:L:R17	R:R:L291	3.64	No	Yes	15	0	6
132	L:L:H18	L:L:S19	4.18	No	No	0	0	0
133	L:L:H18	R:R:P104	6.1	No	No	0	0	3
134	L:L:S19	R:R:T138	3.2	No	No	0	0	2
135	L:L:S20	R:R:Y146	3.82	No	No	0	0	2
136	L:L:G24	L:L:N21	3.39	No	No	0	0	0
137	L:L:F23	R:R:Y146	3.09	No	No	0	0	2
138	L:L:F23	R:R:Y149	3.09	No	Yes	0	0	5
139	L:L:F23	R:R:P207	4.33	No	No	0	0	3
140	L:L:G24	L:L:P25	4.06	No	No	0	0	0
141	L:L:L27	L:L:P28	4.93	No	No	0	0	0
142	L:L:T30	R:R:F99	14.27	Yes	Yes	1	0	5
143	L:L:T30	R:R:D101	8.67	Yes	Yes	1	0	4
144	L:L:T30	R:R:F102	7.78	Yes	Yes	1	0	4
145	L:L:T30	R:R:N135	4.39	Yes	Yes	1	0	3
146	L:L:G33	L:L:N31	5.09	No	No	1	0	0
147	L:L:N31	L:L:N35	8.17	No	No	1	0	0
148	L:L:N31	L:L:T36	4.39	No	Yes	1	0	0
149	L:L:T36	L:L:V32	3.17	Yes	No	0	0	0
150	L:L:G33	L:L:N35	3.39	No	No	1	0	0
151	L:L:G33	L:L:T36	3.64	No	Yes	1	0	0
152	L:L:S34	R:R:H121	8.37	No	Yes	0	0	4
153	L:L:S34	R:R:N124	11.92	No	No	0	0	5
154	L:L:N35	L:L:T36	2.92	No	Yes	1	0	0
155	L:L:P37	L:L:T36	3.5	Yes	Yes	1	0	0
156	L:L:?38	L:L:T36	3.65	Yes	Yes	1	0	0
157	L:L:T36	R:R:W79	4.85	Yes	Yes	1	0	6
158	L:L:T36	R:R:W128	4.85	Yes	Yes	1	0	5
159	L:L:?38	L:L:P37	12.19	Yes	Yes	1	0	0
160	L:L:P37	R:R:D77	4.83	Yes	Yes	1	0	9
161	L:L:P37	R:R:G78	4.06	Yes	Yes	1	0	5
162	L:L:P37	R:R:W79	21.62	Yes	Yes	1	0	6
163	L:L:P37	R:R:R126	5.76	Yes	No	0	0	4
164	L:L:?38	R:R:W128	11.28	Yes	Yes	1	0	5
165	L:L:?38	R:R:S129	7.43	Yes	Yes	1	0	7
166	L:L:?38	R:R:Y131	5.8	Yes	Yes	1	0	5
167	R:R:M48	R:R:R45	3.72	No	No	0	6	7
168	R:R:M49	R:R:R45	3.72	No	No	0	4	7
169	R:R:D97	R:R:K47	6.91	No	No	0	2	4
170	R:R:K47	R:R:Y98	4.78	No	Yes	0	4	4
171	R:R:M48	R:R:Y98	7.18	No	Yes	0	6	4
172	R:R:Q52	R:R:W76	15.33	No	Yes	0	6	8
173	R:R:C55	R:R:W76	5.22	No	Yes	1	9	8
174	R:R:C55	R:R:C81	7.28	No	No	1	9	9
175	R:R:M59	R:R:Y56	8.38	No	Yes	0	5	3
176	R:R:D57	R:R:Q61	5.22	No	No	0	4	3
177	R:R:D83	R:R:R58	10.72	No	No	0	5	3
178	R:R:M59	R:R:R74	9.93	No	No	0	5	4
179	R:R:Q60	R:R:Q61	5.12	No	No	0	3	3
180	R:R:L62	R:R:P63	3.28	No	No	0	3	1
181	R:R:P63	R:R:Q66	4.74	No	No	0	1	1
182	R:R:G67	R:R:Y65	10.14	No	No	0	2	3
183	R:R:Y65	R:R:Y71	35.74	No	No	16	3	3
184	R:R:D84	R:R:Y65	12.64	No	No	16	4	3
185	R:R:G69	R:R:P70	4.06	No	No	0	1	1
186	R:R:A87	R:R:P70	3.74	No	No	0	4	1
187	R:R:D84	R:R:Y71	8.05	No	No	16	4	3
188	R:R:C112	R:R:C72	7.28	No	No	0	9	9
189	R:R:C72	R:R:W118	18.28	No	Yes	0	9	9
190	R:R:D84	R:R:R74	15.48	No	No	0	4	4
191	R:R:T75	R:R:W118	7.28	No	Yes	0	5	9
192	R:R:G78	R:R:W76	5.63	Yes	Yes	1	5	8
193	R:R:C81	R:R:W76	3.92	No	Yes	1	9	8
194	R:R:D77	R:R:G78	5.03	Yes	Yes	1	9	5
195	R:R:D77	R:R:L80	4.07	Yes	Yes	1	9	5
196	R:R:D77	R:R:W82	11.17	Yes	Yes	1	9	9
197	R:R:D77	R:R:S129	5.89	Yes	Yes	1	9	7
198	R:R:D77	R:R:Y131	8.05	Yes	Yes	1	9	5
199	R:R:F99	R:R:W79	13.03	Yes	Yes	1	5	6
200	R:R:W79	R:R:Y131	20.26	Yes	Yes	1	6	5
201	R:R:L80	R:R:Q93	10.65	Yes	No	0	5	6
202	R:R:L80	R:R:P96	11.49	Yes	No	0	5	9
203	R:R:L80	R:R:V108	4.47	Yes	No	1	5	7
204	R:R:L80	R:R:Y131	8.21	Yes	Yes	1	5	5
205	R:R:Q93	R:R:W82	15.33	No	Yes	0	6	9
206	R:R:K110	R:R:W82	23.21	Yes	Yes	1	8	9
207	R:R:S129	R:R:W82	4.94	Yes	Yes	1	7	9
208	R:R:P86	R:R:T85	3.5	No	Yes	1	2	7
209	R:R:T85	R:R:V89	3.17	Yes	No	1	7	5
210	R:R:S91	R:R:T85	6.4	No	Yes	0	5	7
211	R:R:C112	R:R:T85	3.38	No	Yes	0	9	7
212	R:R:T85	R:R:W118	4.85	Yes	Yes	1	7	9
213	R:R:P86	R:R:V89	8.84	No	No	1	2	5
214	R:R:L90	R:R:Y92	3.52	No	No	1	4	4
215	R:R:L90	R:R:T109	7.37	No	No	1	4	5
216	R:R:L90	R:R:Y111	7.03	No	No	0	4	4
217	R:R:K107	R:R:Y92	7.17	No	No	0	3	4
218	R:R:T109	R:R:Y92	8.74	No	No	1	5	4
219	R:R:F94	R:R:K107	9.93	No	No	0	3	3
220	R:R:C95	R:R:P96	3.77	Yes	No	0	9	9
221	R:R:C95	R:R:F102	4.19	Yes	Yes	1	9	4
222	R:R:C95	R:R:V108	3.42	Yes	No	1	9	7
223	R:R:C134	R:R:C95	7.28	No	Yes	1	9	9
224	R:R:P96	R:R:Y98	12.52	No	Yes	0	9	4
225	R:R:F99	R:R:Y98	5.16	Yes	Yes	0	5	4
226	R:R:D101	R:R:F99	3.58	Yes	Yes	1	4	5
227	R:R:F102	R:R:F99	16.08	Yes	Yes	1	4	5
228	R:R:D101	R:R:N135	14.81	Yes	Yes	1	4	3
229	R:R:F102	R:R:Y131	3.09	Yes	Yes	1	4	5
230	R:R:C134	R:R:F102	5.59	No	Yes	1	9	4
231	R:R:F102	R:R:N135	9.67	Yes	Yes	1	4	3
232	R:R:D103	R:R:P104	4.83	No	No	0	3	3
233	R:R:D103	R:R:S105	4.42	No	No	0	3	1
234	R:R:D103	R:R:K141	4.15	No	No	0	3	3
235	R:R:C134	R:R:E106	3.04	No	No	0	9	4
236	R:R:E106	R:R:F137	5.83	No	No	0	4	1
237	R:R:V108	R:R:Y131	15.14	No	Yes	1	7	5
238	R:R:N130	R:R:T109	4.39	Yes	No	1	8	5
239	R:R:K110	R:R:W118	15.08	Yes	Yes	1	8	9
240	R:R:K110	R:R:T127	3	Yes	No	1	8	4
241	R:R:K110	R:R:S129	7.65	Yes	Yes	1	8	7
242	R:R:F119	R:R:Y111	4.13	No	No	0	4	4
243	R:R:D113	R:R:E114	3.9	No	No	17	5	2
244	R:R:D113	R:R:K115	5.53	No	No	17	5	5
245	R:R:D113	R:R:F119	5.97	No	No	0	5	4
246	R:R:E114	R:R:K115	9.45	No	No	17	2	5
247	R:R:K115	R:R:V117	3.04	No	No	0	5	5
248	R:R:T127	R:R:W118	4.85	No	Yes	1	4	9
249	R:R:F119	R:R:P122	4.33	No	No	0	4	5
250	R:R:K120	R:R:T127	3	No	No	0	1	4
251	R:R:H121	R:R:P122	7.63	Yes	No	0	4	5
252	R:R:E123	R:R:H121	4.92	No	Yes	0	4	4
253	R:R:H121	R:R:W128	16.93	Yes	Yes	1	4	5
254	R:R:N124	R:R:R126	6.03	No	No	0	5	4
255	R:R:N130	R:R:W128	10.17	Yes	Yes	1	8	5
256	R:R:S129	R:R:Y131	6.36	Yes	Yes	1	7	5
257	R:R:N130	R:R:T132	5.85	Yes	No	1	8	6
258	R:R:N135	R:R:T138	2.92	Yes	No	0	3	2
259	R:R:A136	R:R:F137	8.32	No	No	0	2	1
260	R:R:F137	R:R:K366	12.41	No	No	0	1	3
261	R:R:P139	R:R:T138	3.5	No	No	0	3	2
262	R:R:K141	R:R:N144	4.2	No	No	0	3	4
263	R:R:L142	R:R:Y146	12.89	No	No	0	2	2
264	R:R:V147	R:R:Y374	5.05	No	No	0	4	6
265	R:R:L148	R:R:Y374	7.03	No	No	0	5	6
266	R:R:H377	R:R:L148	5.14	Yes	No	0	7	5
267	R:R:Y149	R:R:Y150	4.96	Yes	No	0	5	4
268	R:R:I153	R:R:Y149	10.88	No	Yes	0	7	5
269	R:R:L202	R:R:Y149	11.72	No	Yes	0	7	5
270	R:R:L151	R:R:S378	4.5	No	No	0	5	5
271	R:R:A152	R:R:H381	7.32	No	Yes	0	7	9
272	R:R:I153	R:R:I199	4.42	No	No	18	7	7
273	R:R:F382	R:R:G155	6.02	No	No	0	7	8
274	R:R:H156	R:R:S195	9.76	Yes	No	0	7	7
275	R:R:H156	R:R:I198	13.26	Yes	No	0	7	7
276	R:R:H156	R:R:I199	3.98	Yes	No	0	7	7
277	R:R:H156	R:R:H381	10.75	Yes	Yes	0	7	9
278	R:R:L163	R:R:S159	3	Yes	No	0	8	9
279	R:R:S159	R:R:S195	3.26	No	No	0	9	7
280	R:R:I160	R:R:S195	7.74	No	No	0	5	7
281	R:R:F161	R:R:I165	6.28	No	Yes	0	4	5
282	R:R:F385	R:R:T162	6.49	Yes	No	0	5	6
283	R:R:A388	R:R:T162	3.36	No	No	0	8	6
284	R:R:F188	R:R:L163	6.09	No	Yes	0	8	8
285	R:R:L163	R:R:Y191	7.03	Yes	Yes	0	8	8
286	R:R:A388	R:R:L163	3.15	No	Yes	0	8	8
287	R:R:I165	R:R:I169	2.94	Yes	No	0	5	8
288	R:R:F393	R:R:I165	3.77	No	Yes	0	8	5
289	R:R:F188	R:R:S166	6.61	No	No	0	8	9
290	R:R:C392	R:R:S166	6.89	No	No	0	9	9
291	R:R:F188	R:R:L167	6.09	No	Yes	0	8	6
292	R:R:F173	R:R:I169	3.77	Yes	No	0	7	8
293	R:R:I169	R:R:V402	3.07	No	No	0	8	5
294	R:R:F170	R:R:V181	6.55	No	No	0	8	9
295	R:R:C392	R:R:F170	4.19	No	No	0	9	8
296	R:R:F172	R:R:F173	8.57	No	Yes	0	2	7
297	R:R:F173	R:R:L176	3.65	Yes	Yes	19	7	9
298	R:R:F173	R:R:T401	7.78	Yes	Yes	19	7	7
299	R:R:L176	R:R:S175	3	Yes	No	0	9	8
300	R:R:L176	R:R:V398	4.47	Yes	No	0	9	9
301	R:R:L176	R:R:T401	4.42	Yes	Yes	19	9	7
302	R:R:G177	R:R:V181	3.68	No	No	0	7	9
303	R:R:C178	R:R:R180	4.18	No	No	0	8	9
304	R:R:C178	R:R:V181	3.42	No	No	0	8	9
305	R:R:Q179	R:R:Y243	7.89	Yes	Yes	9	7	8
306	R:R:Q179	R:R:Q257	5.12	Yes	Yes	9	7	5
307	R:R:L259	R:R:Q179	11.98	Yes	Yes	0	5	7
308	R:R:H184	R:R:R180	9.03	No	No	0	9	9
309	R:R:L259	R:R:T182	2.95	Yes	No	0	5	5
310	R:R:L183	R:R:W236	3.42	Yes	Yes	0	8	9
311	R:R:E240	R:R:L183	6.63	Yes	Yes	0	9	8
312	R:R:L183	R:R:Y243	3.52	Yes	Yes	0	8	8
313	R:R:L183	R:R:L259	4.15	Yes	Yes	0	8	5
314	R:R:E240	R:R:H184	9.85	Yes	No	0	9	9
315	R:R:H184	R:R:Y391	3.27	No	No	0	9	8
316	R:R:N186	R:R:W236	18.08	No	Yes	6	9	9
317	R:R:N186	R:R:Y263	8.14	No	No	6	9	5
318	R:R:N186	R:R:W267	5.65	No	Yes	6	9	9
319	R:R:M187	R:R:Y191	8.38	No	Yes	0	8	8
320	R:R:E240	R:R:M187	8.12	Yes	No	0	9	8
321	R:R:M229	R:R:T190	3.01	Yes	Yes	0	4	9
322	R:R:N233	R:R:T190	5.85	No	Yes	0	9	9
323	R:R:T190	R:R:W236	3.64	Yes	Yes	6	9	9
324	R:R:T190	R:R:W267	4.85	Yes	Yes	6	9	9
325	R:R:N233	R:R:Y191	12.79	No	Yes	0	9	8
326	R:R:Q383	R:R:Y191	4.51	Yes	Yes	0	9	8
327	R:R:V387	R:R:Y191	5.05	No	Yes	0	9	8
328	R:R:L193	R:R:M229	4.24	No	Yes	0	6	4
329	R:R:I198	R:R:N194	5.66	No	No	0	7	8
330	R:R:N194	R:R:N233	6.81	No	No	0	8	9
331	R:R:H226	R:R:I197	5.3	No	No	0	6	5
332	R:R:I197	R:R:M229	2.92	No	Yes	0	5	4
333	R:R:H226	R:R:I198	3.98	No	No	0	6	7
334	R:R:H201	R:R:V205	9.69	No	No	0	6	7
335	R:R:H201	R:R:L291	5.14	No	Yes	0	6	6
336	R:R:E204	R:R:N208	3.94	No	No	0	4	3
337	R:R:P207	R:R:V206	7.07	No	No	0	3	3
338	R:R:E210	R:R:N208	9.2	No	No	0	3	3
339	R:R:L211	R:R:N208	9.61	No	No	0	1	3
340	R:R:G209	R:R:V212	3.68	No	No	0	3	3
341	R:R:E210	R:R:R213	3.49	No	No	0	3	2
342	R:R:L211	R:R:R214	4.86	No	No	0	1	4
343	R:R:L211	R:R:P216	4.93	No	No	0	1	4
344	R:R:N288	R:R:V212	4.43	No	No	0	4	3
345	R:R:C289	R:R:V212	6.83	No	No	0	9	3
346	R:R:D215	R:R:K220	5.53	No	No	0	6	7
347	R:R:D215	R:R:N288	9.42	No	No	0	6	4
348	R:R:P216	R:R:S218	3.56	No	No	0	4	3
349	R:R:C219	R:R:P216	3.77	No	No	0	9	4
350	R:R:I221	R:R:V217	3.07	No	No	0	4	3
351	R:R:C219	R:R:C289	7.28	No	No	0	9	9
352	R:R:K220	R:R:N286	4.2	No	No	3	7	7
353	R:R:K220	R:R:W290	9.28	No	Yes	3	7	9
354	R:R:H223	R:R:Q227	9.89	No	Yes	0	5	7
355	R:R:H223	R:R:W290	3.17	No	Yes	0	5	9
356	R:R:H223	R:R:L291	3.86	No	Yes	0	5	6
357	R:R:F224	R:R:T274	3.89	No	No	0	5	6
358	R:R:F224	R:R:T275	6.49	No	No	0	5	3
359	R:R:F225	R:R:M229	3.73	No	Yes	0	5	4
360	R:R:M230	R:R:Q227	4.08	Yes	Yes	5	6	7
361	R:R:I301	R:R:Q227	5.49	Yes	Yes	5	7	7
362	R:R:C232	R:R:Y228	9.41	No	No	0	8	8
363	R:R:L271	R:R:Y228	8.21	No	No	0	4	8
364	R:R:M230	R:R:Y234	3.59	Yes	Yes	0	6	7
365	R:R:I301	R:R:M230	2.92	Yes	Yes	5	7	6
366	R:R:H302	R:R:M230	5.25	Yes	Yes	5	6	6
367	R:R:A231	R:R:P270	3.74	No	Yes	0	5	9
368	R:R:C232	R:R:W267	5.22	No	Yes	0	8	9
369	R:R:C232	R:R:P270	3.77	No	Yes	0	8	9
370	R:R:M237	R:R:Y234	4.79	No	Yes	0	9	7
371	R:R:V305	R:R:Y234	5.05	No	Yes	0	7	7
372	R:R:F356	R:R:Y234	11.35	Yes	Yes	0	7	7
373	R:R:F235	R:R:L265	3.65	No	Yes	8	5	7
374	R:R:F235	R:R:F269	5.36	No	Yes	8	5	3
375	R:R:F235	R:R:P270	4.33	No	Yes	8	5	9
376	R:R:C239	R:R:W236	5.22	No	Yes	0	7	9
377	R:R:W236	R:R:Y263	3.86	Yes	No	6	9	5
378	R:R:G266	R:R:W236	5.63	No	Yes	0	9	9
379	R:R:W236	R:R:W267	13.12	Yes	Yes	6	9	9
380	R:R:G353	R:R:M237	3.49	No	No	0	9	9
381	R:R:M237	R:R:Q383	4.08	No	Yes	0	9	9
382	R:R:I242	R:R:L238	5.71	Yes	Yes	0	7	8
383	R:R:A308	R:R:L238	4.73	No	Yes	0	7	8
384	R:R:L238	R:R:N312	4.12	Yes	No	0	8	9
385	R:R:C239	R:R:L265	4.76	No	Yes	0	7	7
386	R:R:E240	R:R:L351	3.98	Yes	Yes	0	9	9
387	R:R:I242	R:R:Y262	4.84	Yes	Yes	0	7	7
388	R:R:F315	R:R:I242	3.77	No	Yes	0	8	7
389	R:R:L247	R:R:Y243	10.55	No	Yes	0	8	8
390	R:R:Q257	R:R:Y243	7.89	Yes	Yes	9	5	8
391	R:R:Y243	R:R:Y262	4.96	Yes	Yes	9	8	7
392	R:R:I248	R:R:L244	4.28	No	No	0	7	9
393	R:R:H245	R:R:V249	9.69	Yes	No	0	8	6
394	R:R:H245	R:R:V250	4.15	Yes	No	0	8	5
395	R:R:F315	R:R:H245	22.63	No	Yes	0	8	8
396	R:R:H245	R:R:N318	7.65	Yes	No	0	8	8
397	R:R:T246	R:R:V250	7.93	No	No	0	7	5
398	R:R:Q257	R:R:T246	8.5	Yes	No	0	5	7
399	R:R:I248	R:R:V249	3.07	No	No	0	7	6
400	R:R:V249	R:R:V322	3.21	No	No	0	6	8
401	R:R:A251	R:R:T254	5.03	No	No	0	6	6
402	R:R:Q257	R:R:Y262	4.51	Yes	Yes	9	5	7
403	R:R:R258	R:R:W261	3	No	Yes	0	5	2
404	R:R:L259	R:R:Y262	3.52	Yes	Yes	0	5	7
405	R:R:L259	R:R:Y263	5.86	Yes	No	0	5	5
406	R:R:F269	R:R:L265	3.65	Yes	Yes	8	3	7
407	R:R:F269	R:R:P270	4.33	Yes	Yes	8	3	9
408	R:R:P273	R:R:V272	7.07	No	No	0	6	4
409	R:R:I301	R:R:T274	7.6	Yes	No	0	7	6
410	R:R:H277	R:R:R281	10.16	No	Yes	0	7	7
411	R:R:H277	R:R:I300	5.3	No	No	0	7	8
412	R:R:H277	R:R:I301	13.26	No	Yes	0	7	7
413	R:R:T280	R:R:Y284	4.99	No	No	0	4	2
414	R:R:L297	R:R:T280	5.9	No	No	0	4	4
415	R:R:F285	R:R:R281	4.28	Yes	Yes	3	6	7
416	R:R:D287	R:R:R281	7.15	Yes	Yes	3	3	7
417	R:R:R281	R:R:W290	14.99	Yes	Yes	3	7	9
418	R:R:V283	R:R:Y284	8.83	No	No	0	3	2
419	R:R:D287	R:R:F285	7.17	Yes	Yes	3	3	6
420	R:R:F285	R:R:S292	3.96	Yes	No	3	6	4
421	R:R:F285	R:R:T295	9.08	Yes	No	3	6	4
422	R:R:F285	R:R:L297	3.65	Yes	No	3	6	4
423	R:R:N286	R:R:W290	6.78	No	Yes	3	7	9
424	R:R:D287	R:R:W290	5.58	Yes	Yes	3	3	9
425	R:R:D287	R:R:S292	4.42	Yes	No	3	3	4
426	R:R:L298	R:R:V293	2.98	No	No	0	6	6
427	R:R:L297	R:R:T295	7.37	No	No	3	4	4
428	R:R:H296	R:R:Y299	6.53	No	No	0	2	7
429	R:R:H302	R:R:L298	9	Yes	No	0	6	6
430	R:R:G303	R:R:P304	4.06	No	Yes	0	4	9
431	R:R:L309	R:R:V305	2.98	No	No	0	7	7
432	R:R:F356	R:R:L309	3.65	Yes	No	0	7	7
433	R:R:F314	R:R:V310	3.93	No	No	0	5	4
434	R:R:F313	R:R:F314	4.29	No	No	0	6	5
435	R:R:F313	R:R:L317	9.74	No	No	0	6	5
436	R:R:L316	R:R:V320	2.98	No	No	0	9	7
437	R:R:I354	R:R:L316	7.14	Yes	No	0	6	9
438	R:R:N318	R:R:R321	7.23	No	No	0	8	8
439	R:R:R321	R:R:V322	5.23	No	No	0	8	8
440	R:R:R328	R:R:V324	7.85	No	No	0	6	5
441	R:R:E329	R:R:K326	8.1	No	No	0	6	9
442	R:R:M337	R:R:R328	3.72	No	No	0	7	6
443	R:R:E332	R:R:H336	11.08	No	No	0	5	6
444	R:R:H336	R:R:K340	22.27	No	Yes	0	6	8
445	R:R:I347	R:R:M346	5.83	No	No	0	8	8
446	R:R:I347	R:R:I390	5.89	No	No	0	8	8
447	R:R:P350	R:R:V349	3.53	No	No	0	9	8
448	R:R:I354	R:R:V349	4.61	Yes	No	0	6	8
449	R:R:L351	R:R:L352	4.15	Yes	No	0	9	9
450	R:R:L351	R:R:V387	2.98	Yes	No	0	9	9
451	R:R:L351	R:R:Y391	16.41	Yes	No	0	9	8
452	R:R:I354	R:R:L352	5.71	Yes	No	0	6	9
453	R:R:G353	R:R:Q355	3.29	No	Yes	10	9	8
454	R:R:F356	R:R:G353	3.01	Yes	No	10	7	9
455	R:R:F356	R:R:Q355	8.2	Yes	Yes	10	7	8
456	R:R:Q355	R:R:Q383	12.8	Yes	Yes	10	8	9
457	R:R:F356	R:R:I380	5.02	Yes	Yes	0	7	6
458	R:R:F356	R:R:Q383	4.68	Yes	Yes	10	7	9
459	R:R:F359	R:R:V358	6.55	No	No	0	6	5
460	R:R:F359	R:R:Y372	6.19	No	Yes	7	6	7
461	R:R:F359	R:R:M376	8.71	No	No	7	6	7
462	R:R:R362	R:R:Y372	7.2	No	Yes	7	4	7
463	R:R:D373	R:R:R362	16.68	No	No	7	5	4
464	R:R:L368	R:R:P363	8.21	No	No	0	3	7
465	R:R:G369	R:R:P363	6.09	No	No	0	4	7
466	R:R:P363	R:R:Y372	9.74	No	Yes	0	7	7
467	R:R:L368	R:R:N365	4.12	No	No	0	3	4
468	R:R:I371	R:R:M367	2.92	No	No	0	5	4
469	R:R:D373	R:R:Y372	3.45	No	Yes	7	5	7
470	R:R:M376	R:R:Y372	5.99	No	Yes	7	7	7
471	R:R:L379	R:R:V375	2.98	No	No	0	5	4
472	R:R:I380	R:R:M376	2.92	Yes	No	0	6	7
473	R:R:H377	R:R:H381	9.55	Yes	Yes	14	7	9
474	R:R:H381	R:R:I380	3.98	Yes	Yes	0	9	6
475	R:R:F382	R:R:F386	3.22	No	No	0	7	5
476	R:R:F385	R:R:F386	6.43	Yes	No	0	5	5
477	R:R:F385	R:R:T389	3.89	Yes	No	0	5	5
478	R:R:F393	R:R:T389	6.49	No	No	0	8	5
479	R:R:I390	R:R:Y391	4.84	No	No	0	8	8
480	R:R:N395	R:R:N396	5.45	No	No	20	9	6
481	R:R:E397	R:R:N395	10.52	No	No	20	9	9
482	R:R:N395	R:R:V398	5.91	No	No	0	9	9
483	R:R:E397	R:R:N396	13.15	No	No	20	9	6
484	R:R:Q405	R:R:T401	5.67	No	Yes	0	4	7
485	R:R:Q405	R:R:R404	4.67	No	No	0	4	7
486	R:R:Q405	R:R:Q408	11.52	No	No	0	4	7
487	R:R:M327	R:R:M337	2.89	No	No	0	7	7
488	R:R:K340	R:R:M327	2.88	Yes	No	0	8	7
489	R:R:E334	R:R:S335	2.87	No	No	0	6	6
490	R:R:I192	R:R:L163	2.85	Yes	Yes	0	7	8
491	R:R:I192	R:R:L167	2.85	Yes	Yes	0	7	6
492	R:R:I319	R:R:L244	2.85	No	No	0	9	9
493	R:R:Q257	R:R:T254	2.83	Yes	No	0	5	6
494	E:E:K79	E:E:L36	2.82	No	Yes	0	2	5
495	R:R:K185	R:R:L167	2.82	No	Yes	0	6	6
496	R:R:E332	R:R:T330	2.82	No	No	0	5	5
497	R:R:M367	R:R:N365	2.8	No	No	0	4	4
498	E:E:A34	E:E:R37	2.77	No	No	0	2	3
499	L:L:F15	R:R:A145	2.77	Yes	No	0	0	4
500	R:R:D50	R:R:K54	2.77	No	No	0	2	4
501	R:R:L189	R:R:L193	2.77	No	No	0	3	6
502	R:R:A278	R:R:F224	2.77	No	No	0	6	5
503	R:R:L244	R:R:L348	2.77	No	No	0	9	9
504	R:R:L316	R:R:L348	2.77	No	No	0	9	9
505	L:L:T9	R:R:H381	2.74	No	Yes	0	0	9
506	R:R:D83	R:R:L62	2.71	No	No	0	5	3
507	R:R:K256	R:R:Q179	2.71	No	Yes	0	5	7
508	R:R:K403	R:R:Q399	2.71	No	No	0	6	7
509	R:R:E140	R:R:K143	2.7	No	No	0	2	1
510	R:R:P360	R:R:W361	2.7	No	No	0	5	4
511	R:R:A51	R:R:Y98	2.67	No	Yes	0	8	4
512	E:E:R61	E:E:V51	2.62	No	Yes	0	4	5
513	E:E:V129	R:R:F269	2.62	No	Yes	0	7	3
514	R:R:F253	R:R:V252	2.62	No	No	0	6	7
515	R:R:R321	R:R:T325	2.59	No	No	0	8	7
516	R:R:V203	R:R:Y149	2.52	No	Yes	0	3	5
517	R:R:F313	R:R:I354	2.51	No	Yes	0	6	6
518	E:E:V51	E:E:W56	2.45	Yes	No	0	5	5
519	E:E:L94	R:R:Y56	2.34	No	Yes	0	7	3
520	E:E:L119	E:E:Y120	2.34	No	No	0	8	5
521	R:R:L264	R:R:W261	2.28	No	Yes	0	3	2
522	E:E:P85	R:R:G78	2.03	No	Yes	0	9	5
523	E:E:G116	E:E:P115	2.03	No	No	0	5	9
524	R:R:G268	R:R:P270	2.03	No	Yes	0	6	9
525	E:E:P114	E:E:P115	1.95	No	No	0	9	9
526	E:E:P126	R:R:P304	1.95	No	Yes	0	9	9
527	L:L:P28	L:L:P29	1.95	No	No	0	0	0
528	R:R:A87	R:R:G116	1.95	No	No	0	4	9
529	R:R:G384	R:R:S159	1.86	No	No	0	9	9
530	E:E:G52	E:E:V51	1.84	No	Yes	0	5	5
531	R:R:G116	R:R:V117	1.84	No	No	0	9	5
532	R:R:G155	R:R:V154	1.84	No	No	0	8	6
533	E:E:G81	E:E:L80	1.71	No	No	0	1	6
534	R:R:G168	R:R:L167	1.71	No	Yes	0	1	6
535	R:R:G241	R:R:L352	1.71	No	No	0	8	9
536	L:L:N22	R:R:G209	1.7	No	No	0	0	3
537	R:R:A282	R:R:V283	1.7	No	No	0	3	3
538	E:E:I106	E:E:P105	1.69	No	No	0	3	7
539	E:E:A70	E:E:T73	1.68	No	Yes	0	8	9
540	R:R:E68	R:R:G69	1.64	No	No	0	1	1
541	L:L:P29	R:R:N135	1.63	No	Yes	0	0	3
542	E:E:I127	R:R:A307	1.62	No	No	0	8	3
543	L:L:A8	R:R:I380	1.62	No	Yes	0	0	6
544	R:R:D101	R:R:P100	1.61	Yes	No	0	4	4
545	R:R:V310	R:R:V357	1.6	No	No	0	4	7
546	E:E:C40	E:E:L36	1.59	No	Yes	11	9	5
547	E:E:C72	E:E:L36	1.59	No	Yes	11	9	5
548	E:E:C82	E:E:L80	1.59	No	No	0	8	6
549	E:E:G98	E:E:H97	1.59	No	Yes	4	5	9
550	R:R:T345	R:R:V320	1.59	No	No	0	9	7
551	R:R:T345	R:R:V349	1.59	No	No	0	9	8
552	R:R:A344	R:R:L323	1.58	No	No	0	9	9
553	R:R:T400	R:R:T401	1.57	No	Yes	0	4	7
554	E:E:C57	E:E:D58	1.56	No	No	0	9	5
555	E:E:A87	E:E:N86	1.56	No	Yes	0	4	9
556	R:R:C81	R:R:D83	1.56	No	No	0	9	5
557	R:R:I153	R:R:S157	1.55	No	No	18	7	7
558	R:R:I199	R:R:S157	1.55	No	No	18	7	7
559	R:R:I165	R:R:V164	1.54	Yes	No	0	5	4
560	R:R:I192	R:R:V164	1.54	Yes	No	0	7	4
561	R:R:I276	R:R:V272	1.54	No	No	0	5	4
562	R:R:A64	R:R:Q66	1.52	No	No	0	1	1
563	R:R:I279	R:R:T275	1.52	No	No	0	3	3
564	R:R:M306	R:R:V357	1.52	No	No	0	4	7
565	E:E:L131	R:R:V311	1.49	No	No	0	8	6
566	R:R:L222	R:R:V205	1.49	No	No	0	6	7
567	R:R:L238	R:R:V311	1.49	Yes	No	0	8	6
568	R:R:I160	R:R:M196	1.46	No	No	0	5	4
569	R:R:I192	R:R:M196	1.46	Yes	No	0	7	4
570	R:R:I200	R:R:M196	1.46	No	No	0	6	4
571	R:R:A333	R:R:H336	1.46	No	No	0	5	6
572	R:R:G88	R:R:Y111	1.45	No	No	0	8	4
573	R:R:I347	R:R:K343	1.45	No	No	0	8	8
574	R:R:I371	R:R:K370	1.45	No	No	0	5	4
575	R:R:K340	R:R:K343	1.44	Yes	No	0	8	8
576	E:E:G60	E:E:W59	1.41	No	Yes	0	4	7
577	E:E:G108	E:E:W59	1.41	No	Yes	0	6	7
578	R:R:E329	R:R:T330	1.41	No	No	0	6	5
579	R:R:K340	R:R:L339	1.41	Yes	No	0	8	6
580	E:E:P121	E:E:Y120	1.39	No	No	0	7	5
581	E:E:A110	E:E:R112	1.38	No	No	0	4	4
582	R:R:E255	R:R:K256	1.35	No	No	0	6	5
583	E:E:E38	E:E:L35	1.33	No	No	0	4	2
584	R:R:L379	R:R:Q355	1.33	No	Yes	0	5	8
585	E:E:R102	E:E:S103	1.32	No	No	0	5	7
586	R:R:H377	R:R:L151	1.29	Yes	No	14	7	5
587	R:R:H381	R:R:L151	1.29	Yes	No	14	9	5
588	E:E:V137	R:R:W261	1.23	No	Yes	0	9	2
589	R:R:F385	R:R:L158	1.22	Yes	No	0	5	4
590	E:E:N31	E:E:Y32	1.16	No	No	0	2	5
591	R:R:N73	R:R:Y71	1.16	No	No	0	4	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	E:E:L36	3.62	4	11	5
2	E:E:L41	7.165	4	2	5
3	E:E:F44	7.65	4	4	9
4	E:E:V51	4.122	5	0	5
5	E:E:W59	5.79	6	0	7
6	E:E:T73	4.025	4	2	9
7	E:E:N86	4.0575	4	0	9
8	E:E:F92	8.696	5	2	5
9	E:E:F93	7.0625	4	2	9
10	E:E:H97	6.936	5	4	9
11	E:E:Y100	7.41	4	2	8
12	H:H:?1	11.972	5	1	0
13	L:L:F15	7.015	4	0	0
14	L:L:T30	8.7775	4	1	0
15	L:L:T36	3.87125	8	1	0
16	L:L:P37	8.66	6	1	0
17	L:L:?38	8.07	5	1	0
18	R:R:Y56	7.124	5	0	3
19	R:R:W76	7.525	4	1	8
20	R:R:D77	6.50667	6	1	9
21	R:R:G78	4.1875	4	1	5
22	R:R:W79	14.94	4	1	6
23	R:R:L80	7.778	5	1	5
24	R:R:W82	13.6625	4	1	9
25	R:R:T85	4.26	5	1	7
26	R:R:C95	4.665	4	1	9
27	R:R:Y98	6.462	5	0	4
28	R:R:F99	10.424	5	1	5
29	R:R:D101	7.1675	4	1	4
30	R:R:F102	7.73333	6	1	4
31	R:R:K110	12.235	4	1	8
32	R:R:W118	10.068	5	1	9
33	R:R:H121	8.724	5	1	4
34	R:R:W128	10.69	5	1	5
35	R:R:S129	6.454	5	1	7
36	R:R:N130	12.8025	4	1	8
37	R:R:Y131	9.55857	7	1	5
38	R:R:N135	6.684	5	1	3
39	R:R:Y149	6.115	6	0	5
40	R:R:H156	9.4375	4	0	7
41	R:R:L163	4.424	5	0	8
42	R:R:I165	3.6325	4	0	5
43	R:R:L167	3.3675	4	0	6
44	R:R:F173	5.9425	4	19	7
45	R:R:L176	3.885	4	19	9
46	R:R:Q179	6.925	4	9	7
47	R:R:L183	4.43	4	0	8
48	R:R:T190	4.3375	4	6	9
49	R:R:Y191	7.552	5	0	8
50	R:R:I192	2.175	4	0	7
51	R:R:Q227	5.825	4	5	7
52	R:R:M229	3.475	4	0	4
53	R:R:M230	3.96	4	5	6
54	R:R:Y234	6.204	5	0	7
55	R:R:W236	7.56714	7	6	9
56	R:R:L238	4.684	5	0	8
57	R:R:E240	7.145	4	0	9
58	R:R:I242	4.7325	4	0	7
59	R:R:Y243	6.962	5	9	8
60	R:R:H245	11.03	4	0	8
61	R:R:Q257	5.77	5	9	5
62	R:R:L259	5.692	5	0	5
63	R:R:W261	5.1875	4	0	2
64	R:R:Y262	5.092	5	9	7
65	R:R:L265	4.505	4	8	7
66	R:R:W267	7.21	4	6	9
67	R:R:F269	5.705	6	8	3
68	R:R:P270	3.64	5	8	9
69	R:R:R281	9.145	4	3	7
70	R:R:F285	5.43429	7	3	6
71	R:R:D287	6.08	4	3	3
72	R:R:W290	7.96	5	3	9
73	R:R:L291	4.485	4	15	6
74	R:R:I301	7.3175	4	5	7
75	R:R:H302	6.578	5	5	6
76	R:R:P304	4.085	4	0	9
77	R:R:K340	7	4	0	8
78	R:R:L351	6.88	4	0	9
79	R:R:I354	4.9925	4	0	6
80	R:R:Q355	6.405	4	10	8
81	R:R:F356	5.72429	7	10	7
82	R:R:Y372	6.514	5	7	7
83	R:R:H377	5.9225	4	14	7
84	R:R:I380	3.385	4	0	6
85	R:R:H381	5.93833	6	14	9
86	R:R:Q383	6.5175	4	10	9
87	R:R:F385	4.5075	4	0	5
88	R:R:T401	4.86	4	19	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	E:E:R61	E:E:V51	11.5351	2.62	No	Yes	0	4	5
2	E:E:V51	E:E:W56	14.7984	2.45	Yes	No	0	5	5
3	E:E:M48	E:E:W56	16.4246	10.47	No	No	0	9	5
4	E:E:F101	E:E:M48	17.0843	4.98	No	No	4	9	9
5	E:E:F101	E:E:H97	19.5028	11.31	No	Yes	4	9	9
6	E:E:H97	R:R:Y56	37.7898	6.53	Yes	Yes	0	9	3
7	E:E:F93	R:R:Y56	45.5648	10.32	Yes	Yes	0	9	3
8	E:E:F92	E:E:F93	10.6523	7.5	Yes	Yes	2	5	9
9	E:E:H97	R:R:Y53	10.6229	3.27	Yes	No	4	9	1
10	E:E:W74	E:E:W84	67.6228	15.93	No	No	0	6	7
11	E:E:T73	E:E:W84	66.126	6.06	Yes	No	0	9	7
12	E:E:W74	R:R:R45	71.3467	5	No	No	0	6	7
13	R:R:F99	R:R:W79	10.2315	13.03	Yes	Yes	1	5	6
14	R:R:F99	R:R:Y98	73.0589	5.16	Yes	Yes	0	5	4
15	R:R:M48	R:R:Y98	73.5647	7.18	No	Yes	0	6	4
16	R:R:M48	R:R:R45	72.8317	3.72	No	No	0	6	7
17	L:L:T30	R:R:F99	25.6036	14.27	Yes	Yes	1	0	5
18	L:L:T30	R:R:N135	25.7692	4.39	Yes	Yes	1	0	3
19	R:R:N135	R:R:T138	99.4996	2.92	Yes	No	0	3	2
20	L:L:S19	R:R:T138	99.5756	3.2	No	No	0	0	2
21	L:L:F15	L:L:S19	99.2882	9.25	Yes	No	0	0	0
22	L:L:F15	R:R:L142	99.7023	4.87	Yes	No	0	0	2
23	R:R:L142	R:R:Y146	99.7294	12.89	No	No	0	2	2
24	L:L:F23	R:R:Y146	99.781	3.09	No	No	0	0	2
25	L:L:F23	R:R:Y149	99.6272	3.09	No	Yes	0	0	5
26	R:R:I153	R:R:Y149	99.9511	10.88	No	Yes	0	7	5
27	R:R:I153	R:R:I199	99.7638	4.42	No	No	18	7	7
28	R:R:H156	R:R:I199	100	3.98	Yes	No	0	7	7
29	R:R:H156	R:R:I198	63.8418	13.26	Yes	No	0	7	7
30	R:R:H226	R:R:I198	28.023	3.98	No	No	0	6	7
31	L:L:Q10	R:R:H226	33.5143	7.42	No	No	0	0	6
32	L:L:Q10	R:R:Q227	33.2329	3.84	No	Yes	0	0	7
33	R:R:H223	R:R:Q227	24.8027	9.89	No	Yes	0	5	7
34	R:R:H223	R:R:W290	20.6073	3.17	No	Yes	0	5	9
35	R:R:D101	R:R:F99	25.7231	3.58	Yes	Yes	1	4	5
36	R:R:D101	R:R:N135	26.0298	14.81	Yes	Yes	1	4	3
37	R:R:F102	R:R:F99	26.5371	16.08	Yes	Yes	1	4	5
38	R:R:F102	R:R:N135	47.5892	9.67	Yes	Yes	1	4	3
39	R:R:F285	R:R:R281	15.9531	4.28	Yes	Yes	3	6	7
40	R:R:H277	R:R:I301	11.2039	13.26	No	Yes	0	7	7
41	R:R:H277	R:R:R281	10.3722	10.16	No	Yes	0	7	7
42	R:R:F285	R:R:L297	18.154	3.65	Yes	No	3	6	4
43	R:R:L297	R:R:T280	17.1685	5.9	No	No	0	4	4
44	R:R:T280	R:R:Y284	12.1459	4.99	No	No	0	4	2
45	R:R:I198	R:R:N194	36.1034	5.66	No	No	0	7	8
46	R:R:N194	R:R:N233	35.9355	6.81	No	No	0	8	9
47	R:R:N233	R:R:T190	29.8741	5.85	No	Yes	0	9	9
48	R:R:T190	R:R:W236	29.9972	3.64	Yes	Yes	6	9	9
49	R:R:L183	R:R:W236	16.9925	3.42	Yes	Yes	0	8	9
50	R:R:L183	R:R:Y243	13.4188	3.52	Yes	Yes	0	8	8
51	R:R:I242	R:R:Y262	16.1694	4.84	Yes	Yes	0	7	7
52	R:R:L259	R:R:Y262	11.5722	3.52	Yes	Yes	0	5	7
53	R:R:H156	R:R:H381	15.0011	10.75	Yes	Yes	0	7	9
54	R:R:H381	R:R:I380	12.888	3.98	Yes	Yes	0	9	6
55	R:R:F356	R:R:I380	11.7138	5.02	Yes	Yes	0	7	6
56	R:R:F356	R:R:Y234	14.0654	11.35	Yes	Yes	0	7	7
57	R:R:M230	R:R:Y234	12.9943	3.59	Yes	Yes	0	6	7
58	R:R:F102	R:R:Y131	20.9435	3.09	Yes	Yes	1	4	5
59	R:R:H156	R:R:S195	24.5163	9.76	Yes	No	0	7	7
60	R:R:S159	R:R:S195	18.6481	3.26	No	No	0	9	7
61	R:R:L163	R:R:S159	18.4119	3	Yes	No	0	8	9
62	R:R:I192	R:R:V164	11.5315	1.54	Yes	No	0	7	4
63	R:R:I165	R:R:V164	10.9355	1.54	Yes	No	0	5	4
64	R:R:L163	R:R:Y191	16.5459	7.03	Yes	Yes	0	8	8
65	R:R:N233	R:R:Y191	12.2613	12.79	No	Yes	0	9	8
66	R:R:V387	R:R:Y191	20.2051	5.05	No	Yes	0	9	8
67	R:R:L351	R:R:V387	19.7128	2.98	Yes	No	0	9	9
68	R:R:L351	R:R:Y391	10.141	16.41	Yes	No	0	9	8
69	R:R:L351	R:R:L352	10.765	4.15	Yes	No	0	9	9
70	R:R:I390	R:R:Y391	10.231	4.84	No	No	0	8	8
71	E:E:F93	E:E:T73	55.9542	5.19	Yes	Yes	2	9	9
72	R:R:Q383	R:R:Y191	15.3083	4.51	Yes	Yes	0	9	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
E:E:F83	R:R:R126	13.9	0	No	No	5	4	2	1
H:H:?1	R:R:H121	5.77	1	Yes	Yes	0	4	2	1
H:H:?1	R:R:W128	10.22	1	Yes	Yes	0	5	2	1
H:H:?1	R:R:N130	30.8	1	Yes	Yes	0	8	2	2
L:L:K1	R:R:E294	5.4	0	No	No	0	3	0	1
L:L:C2	R:R:Y299	4.03	5	No	No	0	7	0	1
L:L:C2	R:R:H302	4.42	5	No	Yes	0	6	0	1
L:L:N3	R:R:W361	7.91	0	No	No	0	4	0	1
L:L:T4	R:R:Y299	7.49	0	No	No	0	7	0	1
L:L:A5	R:R:F356	4.16	0	No	Yes	0	7	0	1
L:L:T6	R:R:Y234	6.24	0	No	Yes	0	7	0	1
L:L:T6	R:R:H302	6.85	0	No	Yes	0	6	0	1
L:L:C7	R:R:H302	7.37	5	No	Yes	0	6	0	1
L:L:Q10	R:R:H226	7.42	0	No	No	0	6	0	1
L:L:Q10	R:R:Q227	3.84	0	No	Yes	0	7	0	1
L:L:R11	R:R:V293	3.92	0	No	No	0	6	0	1
L:L:L12	R:R:H377	7.71	0	No	Yes	0	7	0	1
L:L:A13	R:R:H201	2.93	0	No	No	0	6	0	1
L:L:E14	R:R:L291	5.3	15	No	Yes	0	6	0	1
L:L:E14	R:R:V293	4.28	15	No	No	0	6	0	1
L:L:F15	R:R:K141	11.17	0	Yes	No	0	3	0	1
L:L:F15	R:R:L142	4.87	0	Yes	No	0	2	0	1
L:L:L16	R:R:Y149	3.52	0	No	Yes	0	5	0	1
L:L:L16	R:R:V206	4.47	0	No	No	0	3	0	1
L:L:R17	R:R:L291	3.64	15	No	Yes	0	6	0	1
L:L:H18	R:R:P104	6.1	0	No	No	0	3	0	1
L:L:S19	R:R:T138	3.2	0	No	No	0	2	0	1
L:L:S20	R:R:Y146	3.82	0	No	No	0	2	0	1
L:L:F23	R:R:Y146	3.09	0	No	No	0	2	0	1
L:L:F23	R:R:Y149	3.09	0	No	Yes	0	5	0	1
L:L:F23	R:R:P207	4.33	0	No	No	0	3	0	1
L:L:T30	R:R:F99	14.27	1	Yes	Yes	0	5	0	1
L:L:T30	R:R:D101	8.67	1	Yes	Yes	0	4	0	1
L:L:T30	R:R:F102	7.78	1	Yes	Yes	0	4	0	1
L:L:T30	R:R:N135	4.39	1	Yes	Yes	0	3	0	1
L:L:S34	R:R:H121	8.37	0	No	Yes	0	4	0	1
L:L:S34	R:R:N124	11.92	0	No	No	0	5	0	1
L:L:T36	R:R:W79	4.85	1	Yes	Yes	0	6	0	1
L:L:T36	R:R:W128	4.85	1	Yes	Yes	0	5	0	1
L:L:P37	R:R:D77	4.83	1	Yes	Yes	0	9	0	1
L:L:P37	R:R:G78	4.06	1	Yes	Yes	0	5	0	1
L:L:P37	R:R:W79	21.62	1	Yes	Yes	0	6	0	1
L:L:P37	R:R:R126	5.76	1	Yes	No	0	4	0	1
L:L:?38	R:R:W128	11.28	1	Yes	Yes	0	5	0	1
L:L:?38	R:R:S129	7.43	1	Yes	Yes	0	7	0	1
L:L:?38	R:R:Y131	5.8	1	Yes	Yes	0	5	0	1
R:R:G78	R:R:W76	5.63	1	Yes	Yes	5	8	1	2
R:R:D77	R:R:G78	5.03	1	Yes	Yes	9	5	1	1
R:R:D77	R:R:L80	4.07	1	Yes	Yes	9	5	1	2
R:R:D77	R:R:W82	11.17	1	Yes	Yes	9	9	1	2
R:R:D77	R:R:S129	5.89	1	Yes	Yes	9	7	1	1
R:R:D77	R:R:Y131	8.05	1	Yes	Yes	9	5	1	1
R:R:F99	R:R:W79	13.03	1	Yes	Yes	5	6	1	1
R:R:W79	R:R:Y131	20.26	1	Yes	Yes	6	5	1	1
R:R:L80	R:R:V108	4.47	1	Yes	No	5	7	2	2
R:R:L80	R:R:Y131	8.21	1	Yes	Yes	5	5	2	1
R:R:K110	R:R:W82	23.21	1	Yes	Yes	8	9	2	2
R:R:S129	R:R:W82	4.94	1	Yes	Yes	7	9	1	2
R:R:C95	R:R:F102	4.19	1	Yes	Yes	9	4	2	1
R:R:C95	R:R:V108	3.42	1	Yes	No	9	7	2	2
R:R:C134	R:R:C95	7.28	1	No	Yes	9	9	2	2
R:R:F99	R:R:Y98	5.16	1	Yes	Yes	5	4	1	2
R:R:D101	R:R:F99	3.58	1	Yes	Yes	4	5	1	1
R:R:F102	R:R:F99	16.08	1	Yes	Yes	4	5	1	1
R:R:D101	R:R:N135	14.81	1	Yes	Yes	4	3	1	1
R:R:F102	R:R:Y131	3.09	1	Yes	Yes	4	5	1	1
R:R:C134	R:R:F102	5.59	1	No	Yes	9	4	2	1
R:R:F102	R:R:N135	9.67	1	Yes	Yes	4	3	1	1
R:R:D103	R:R:P104	4.83	0	No	No	3	3	2	1
R:R:D103	R:R:K141	4.15	0	No	No	3	3	2	1
R:R:V108	R:R:Y131	15.14	1	No	Yes	7	5	2	1
R:R:K110	R:R:S129	7.65	1	Yes	Yes	8	7	2	1
R:R:H121	R:R:P122	7.63	1	Yes	No	4	5	1	2
R:R:E123	R:R:H121	4.92	0	No	Yes	4	4	2	1
R:R:H121	R:R:W128	16.93	1	Yes	Yes	4	5	1	1
R:R:N124	R:R:R126	6.03	0	No	No	5	4	1	1
R:R:N130	R:R:W128	10.17	1	Yes	Yes	8	5	2	1
R:R:S129	R:R:Y131	6.36	1	Yes	Yes	7	5	1	1
R:R:N135	R:R:T138	2.92	1	Yes	No	3	2	1	1
R:R:P139	R:R:T138	3.5	0	No	No	3	2	2	1
R:R:K141	R:R:N144	4.2	0	No	No	3	4	1	2
R:R:L142	R:R:Y146	12.89	0	No	No	2	2	1	1
R:R:H377	R:R:L148	5.14	14	Yes	No	7	5	1	2
R:R:Y149	R:R:Y150	4.96	0	Yes	No	5	4	1	2
R:R:I153	R:R:Y149	10.88	18	No	Yes	7	5	2	1
R:R:L202	R:R:Y149	11.72	0	No	Yes	7	5	2	1
R:R:A152	R:R:H381	7.32	0	No	Yes	7	9	2	1
R:R:H156	R:R:I198	13.26	0	Yes	No	7	7	2	2
R:R:H156	R:R:H381	10.75	0	Yes	Yes	7	9	2	1
R:R:H226	R:R:I197	5.3	0	No	No	6	5	1	2
R:R:H226	R:R:I198	3.98	0	No	No	6	7	1	2
R:R:H201	R:R:V205	9.69	0	No	No	6	7	1	2
R:R:H201	R:R:L291	5.14	0	No	Yes	6	6	1	1
R:R:P207	R:R:V206	7.07	0	No	No	3	3	1	1
R:R:G209	R:R:V212	3.68	0	No	No	3	3	1	2
R:R:H223	R:R:Q227	9.89	0	No	Yes	5	7	2	1
R:R:H223	R:R:L291	3.86	0	No	Yes	5	6	2	1
R:R:M230	R:R:Q227	4.08	5	Yes	Yes	6	7	2	1
R:R:I301	R:R:Q227	5.49	5	Yes	Yes	7	7	2	1
R:R:M230	R:R:Y234	3.59	5	Yes	Yes	6	7	2	1
R:R:I301	R:R:M230	2.92	5	Yes	Yes	7	6	2	2
R:R:H302	R:R:M230	5.25	5	Yes	Yes	6	6	1	2
R:R:M237	R:R:Y234	4.79	0	No	Yes	9	7	2	1
R:R:V305	R:R:Y234	5.05	0	No	Yes	7	7	2	1
R:R:F356	R:R:Y234	11.35	10	Yes	Yes	7	7	1	1
R:R:G353	R:R:M237	3.49	10	No	No	9	9	2	2
R:R:M237	R:R:Q383	4.08	0	No	Yes	9	9	2	2
R:R:L298	R:R:V293	2.98	0	No	No	6	6	2	1
R:R:H296	R:R:Y299	6.53	0	No	No	2	7	2	1
R:R:H302	R:R:L298	9	5	Yes	No	6	6	1	2
R:R:L309	R:R:V305	2.98	0	No	No	7	7	2	2
R:R:F356	R:R:L309	3.65	10	Yes	No	7	7	1	2
R:R:G353	R:R:Q355	3.29	10	No	Yes	9	8	2	2
R:R:F356	R:R:G353	3.01	10	Yes	No	7	9	1	2
R:R:F356	R:R:Q355	8.2	10	Yes	Yes	7	8	1	2
R:R:Q355	R:R:Q383	12.8	10	Yes	Yes	8	9	2	2
R:R:F356	R:R:I380	5.02	10	Yes	Yes	7	6	1	1
R:R:F356	R:R:Q383	4.68	10	Yes	Yes	7	9	1	2
R:R:I380	R:R:M376	2.92	0	Yes	No	6	7	1	2
R:R:H377	R:R:H381	9.55	14	Yes	Yes	7	9	1	1
R:R:H381	R:R:I380	3.98	14	Yes	Yes	9	6	1	1
L:L:F15	R:R:A145	2.77	0	Yes	No	0	4	0	1
L:L:T9	R:R:H381	2.74	0	No	Yes	0	9	0	1
R:R:P360	R:R:W361	2.7	0	No	No	5	4	2	1
R:R:V203	R:R:Y149	2.52	0	No	Yes	3	5	2	1
E:E:P85	R:R:G78	2.03	0	No	Yes	9	5	2	1
L:L:N22	R:R:G209	1.7	0	No	No	0	3	0	1
L:L:P29	R:R:N135	1.63	0	No	Yes	0	3	0	1
L:L:A8	R:R:I380	1.62	0	No	Yes	0	6	0	1
R:R:D101	R:R:P100	1.61	1	Yes	No	4	4	1	2
R:R:H377	R:R:L151	1.29	14	Yes	No	7	5	1	2
R:R:H381	R:R:L151	1.29	14	Yes	No	9	5	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9BLW_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.92
Number of Linked Nodes	496
Number of Links	591
Number of Hubs	88
Number of Links mediated by Hubs	316
Number of Communities	20
Number of Nodes involved in Communities	125
Number of Links involved in Communities	172

Path Summary
Number Of Nodes in MetaPath	73
Number Of Links MetaPath	72
Number of Shortest Paths	344512
Length Of Smallest Path	3
Average Path Length	24.4131
Length of Longest Path	52
Minimum Path Strength	1.41
Average Path Strength	6.37968
Maximum Path Strength	22.94
Minimum Path Correlation	0.71
Average Path Correlation	0.965382
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.0303
Average % Of Corr. Nodes	50.905
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	45.5297
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • cellular homeostasis • chemical homeostasis • homeostatic process • glucose homeostasis • carbohydrate homeostasis • intracellular chemical homeostasis • intracellular glucose homeostasis • system process • regulation of biological process • nervous system process • neuromuscular process • regulation of system process • biological regulation • skeletal muscle contraction • muscle contraction • muscle system process • regulation of muscle system process • striated muscle contraction • multicellular organismal movement • musculoskeletal movement • regulation of striated muscle contraction • regulation of muscle contraction • regulation of skeletal muscle contraction • regulation of multicellular organismal process • sensory perception of chemical stimulus • sensory perception • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • response to pH • cellular response to pH • response to abiotic stimulus • cellular response to acidic pH • response to acidic pH • cellular response to abiotic stimulus • cellular response to environmental stimulus • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • positive regulation of biological process • adaptive thermogenesis • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • positive regulation of cell communication • regulation of localization • establishment of protein localization • nitrogen compound transport • positive regulation of establishment of protein localization • localization • establishment of localization in cell • positive regulation of insulin secretion involved in cellular response to glucose stimulus • positive regulation of insulin secretion • intracellular protein localization • regulation of peptide hormone secretion • regulation of hormone levels • positive regulation of peptide hormone secretion • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • cellular response to carbohydrate stimulus • response to glucose • positive regulation of protein localization • insulin secretion involved in cellular response to glucose stimulus • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • positive regulation of secretion by cell • hormone secretion • protein localization to extracellular region • positive regulation of protein transport • peptide secretion • regulation of secretion by cell • secretion by cell • positive regulation of hormone secretion • response to monosaccharide • response to carbohydrate • positive regulation of secretion • signal release • cellular response to hexose stimulus • cellular response to monosaccharide stimulus • positive regulation of cellular process • positive regulation of peptide secretion • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • cellular response to glucose stimulus • regulation of protein transport • positive regulation of protein secretion • peptide transport • response to hexose • positive regulation of transport • regulation of cellular localization • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • regulation of insulin secretion involved in cellular response to glucose stimulus • hormone transport • regulation of cell communication • insulin secretion • positive regulation of signaling • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • cellular response to catecholamine stimulus • serotonin receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-activating serotonin receptor signaling pathway • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • adenylate cyclase-activating dopamine receptor signaling pathway • G protein-coupled dopamine receptor signaling pathway • cell surface receptor signaling pathway • bile acid signaling pathway • adenylate cyclase-activating G protein-coupled bile acid receptor signaling pathway • renal system process • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • amyloid-beta binding • binding • peptide binding • calcitonin family receptor activity • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • calcitonin receptor activity • amylin receptor activity • calcitonin gene-related peptide receptor activity • calcitonin binding • calcitonin family binding • peptide hormone binding • hormone binding • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • cellular response to stimulus • positive regulation of cell communication • regulation of cellular process • positive regulation of signal transduction • response to stimulus • signaling • positive regulation of biological process • regulation of signal transduction • intracellular signal transduction • cell communication • positive regulation of response to stimulus • regulation of intracellular signal transduction • intracellular signaling cassette • regulation of calcium-mediated signaling • positive regulation of calcium-mediated signaling • signal transduction • positive regulation of cellular process • regulation of biological process • regulation of signaling • positive regulation of intracellular signal transduction • regulation of response to stimulus • calcium-mediated signaling • regulation of cell communication • cellular process • positive regulation of signaling • catabolic process • negative regulation of biological process • RNA metabolic process • macromolecule catabolic process • regulation of primary metabolic process • nucleobase-containing compound metabolic process • post-transcriptional regulation of gene expression • regulation of RNA metabolic process • regulation of mRNA catabolic process • negative regulation of cellular process • regulation of nucleobase-containing compound metabolic process • RNA catabolic process • negative regulation of macromolecule metabolic process • regulation of biosynthetic process • mRNA catabolic process • negative regulation of metabolic process • primary metabolic process • regulation of macromolecule metabolic process • regulation of catabolic process • gene expression • mRNA metabolic process • macromolecule biosynthetic process • nucleic acid metabolic process • nucleobase-containing compound catabolic process • regulation of mRNA stability • regulation of gene expression • negative regulation of gene expression • biosynthetic process • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • regulation of RNA stability • nucleic acid catabolic process • metabolic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • regulation of mRNA metabolic process • regulation of metabolic process • positive regulation of ERK1 and ERK2 cascade • positive regulation of MAPK cascade • regulation of MAPK cascade • MAPK cascade • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of macromolecule biosynthetic process • positive regulation of metabolic process • positive regulation of gene expression • positive regulation of biosynthetic process • positive regulation of macromolecule metabolic process • amylin receptor 1 signaling pathway • amylin receptor signaling pathway • calcitonin family receptor signaling pathway • G protein-coupled receptor signaling pathway • regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • phosphatidylinositol 3-kinase/protein kinase B signal transduction • response to corticosteroid • response to lipid • response to hormone • response to steroid hormone • response to chemical • response to endogenous stimulus • response to glucocorticoid • adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • response to amyloid-beta • cell surface receptor signaling pathway • calcitonin gene-related peptide receptor signaling pathway • multicellular organismal process • ossification • amylin receptor 2 signaling pathway • developmental process • myeloid leukocyte differentiation • cellular developmental process • hemopoiesis • cell development • myeloid cell differentiation • cell differentiation • osteoclast differentiation • anatomical structure development • leukocyte differentiation • positive regulation of cAMP/PKA signal transduction • cAMP/PKA signal transduction • regulation of cAMP/PKA signal transduction • regulation of multicellular organismal process • negative regulation of multicellular organismal process • regulation of ossification • negative regulation of ossification • amylin receptor 3 signaling pathway • cell projection • cilium • plasma membrane bounded cell projection • amylin receptor complex • amylin receptor complex 3 • receptor complex • plasma membrane signaling receptor complex • G protein-coupled receptor complex • calcitonin family receptor complex • amylin receptor complex 2 • amylin receptor complex 1 • axon • neuron projection • acrosomal vesicle • intracellular vesicle • cytoplasmic vesicle • secretory granule • secretory vesicle • protein binding • signaling receptor binding • molecular function activator activity • molecular function regulator activity • signaling receptor regulator activity • receptor ligand activity • signaling receptor activator activity • hormone activity • lipid binding • identical protein binding • apoptotic process • cell death • programmed cell death • positive regulation of programmed cell death • regulation of apoptotic process • regulation of programmed cell death • positive regulation of apoptotic process • behavior • eating behavior • feeding behavior • cell-cell signaling • regulation of cellular component organization • negative regulation of cellular component organization • protein-containing complex organization • regulation of cellular component biogenesis • negative regulation of protein-containing complex assembly • cellular component organization • cellular component biogenesis • regulation of protein-containing complex assembly • cellular component assembly • protein-containing complex assembly • cellular component organization or biogenesis • regulation of leukocyte differentiation • regulation of developmental process • regulation of cell differentiation • regulation of cell development • regulation of osteoclast differentiation • multicellular organism development • regulation of immune system process • negative regulation of cell differentiation • negative regulation of hemopoiesis • regulation of multicellular organismal development • negative regulation of leukocyte differentiation • regulation of myeloid cell differentiation • negative regulation of developmental process • regulation of myeloid leukocyte differentiation • negative regulation of myeloid cell differentiation • negative regulation of osteoclast differentiation • negative regulation of myeloid leukocyte differentiation • negative regulation of cell development • negative regulation of immune system process • immune system process • regulation of hemopoiesis • negative regulation of tissue remodeling • homeostatic process • negative regulation of bone remodeling • regulation of bone remodeling • tissue homeostasis • regulation of tissue remodeling • regulation of bone resorption • bone resorption • negative regulation of bone resorption • multicellular organismal-level homeostasis • tissue remodeling • bone remodeling • anatomical structure homeostasis • system process • sensory perception • nervous system process • sensory perception of pain • negative regulation of amyloid fibril formation • regulation of amyloid fibril formation • amyloid fibril formation • negative regulation of supramolecular fiber organization • protein metabolic process • negative regulation of protein metabolic process • regulation of protein metabolic process • regulation of supramolecular fiber organization • supramolecular fiber organization • somatodendritic compartment • cell body • neuronal cell body • calcitonin gene-related peptide binding • coreceptor activity • cellular localization • establishment of protein localization • transport • intracellular transport • establishment of localization • localization • protein transport • establishment of localization in cell • macromolecule localization • intracellular protein localization • intracellular protein transport • regulation of G protein-coupled receptor signaling pathway • import into cell • receptor internalization • receptor-mediated endocytosis • endocytosis • vesicle-mediated transport • blood vessel morphogenesis • tube development • angiogenesis • vasculature development • circulatory system development • anatomical structure morphogenesis • tube morphogenesis • anatomical structure formation involved in morphogenesis • blood vessel development • system development • positive regulation of glycoprotein metabolic process • positive regulation of protein metabolic process • carbohydrate derivative metabolic process • regulation of glycoprotein biosynthetic process • positive regulation of glycoprotein biosynthetic process • carbohydrate derivative biosynthetic process • glycoprotein biosynthetic process • glycoprotein metabolic process • regulation of glycoprotein metabolic process • monoatomic ion transport • monoatomic cation transport • calcium ion transport • metal ion transport • protein localization to cell periphery • protein localization to plasma membrane • localization within membrane • protein localization to membrane • cellular response to endogenous stimulus • cellular response to chemical stimulus • cellular response to hormone stimulus • cell surface • CGRP receptor complex • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to monoamine stimulus • response to ketone • response to prostaglandin • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • synapse • cell junction • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception of taste • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • small GTPase-mediated signal transduction • Ras protein signal transduction • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome
SCOP2	Domain Identifier	• G protein-coupled receptor-like • RAMP1-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • RAMP1-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	NAG
PDB Residues	H:H:?1
Environment Details	Open EMBL-EBI Page
Code	NAG
Name	N-Acetylglucosamine
Synonyms	N-Acetylchitosamine
Identifier
Formula	C8 H15 N O6
Molecular Weight	221.208
SMILES
PubChem	24139
Formal Charge	0
Total Atoms	30
Total Chiral Atoms	5
Total Bonds	30
Total Aromatic Bonds	0


Code	NH2
PDB Residues	L:L:?38
Environment Details	Open EMBL-EBI Page
Code	NH2
Name	AMINO GROUP
Synonyms
Identifier
Formula	H2 N
Molecular Weight	16.023
SMILES
PubChem	123329
Formal Charge	0
Total Atoms	3
Total Chiral Atoms	0
Total Bonds	2
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	E
Protein	RAMP1
UniProt	O60894
Sequence	>9BLW_nogp_Chain_E N Y G A L L R E L C L T Q F Q V D M E A V G E T L W C D W G R T I R S Y R E L A D C T W H M A E K L G C F W P N A E V D R F F L A V H G R Y F R S C P I S G R A V R D P P G S I L Y P F I V V P I T V T L L V T A L V V W Q S K R T Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	L
Protein	Cagrilintide (non-acylated)
UniProt	P10997
Sequence	>9BLW_nogp_Chain_L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	R
Protein	Receptor
UniProt	P30988
Sequence	>9BLW_nogp_Chain_R R K K M M D A Q Y K C Y D R M Q Q L P A Y Q G E G P Y C N R T W D G W L C W D D T P A G V L S Y Q F C P D Y F P D F D P S E K V T K Y C D E K G V W F K H P E N N R T W S N Y T M C N A F T P E K L K N A Y V L Y Y L A I V G H S L S I F T L V I S L G I F V F F R S L G C Q R V T L H K N M F L T Y I L N S M I I I I H L V E V V P N G E L V R R D P V S C K I L H F F H Q Y M M A C N Y F W M L C E G I Y L H T L I V V A V F T E K Q R L R W Y Y L L G W G F P L V P T T I H A I T R A V Y F N D N C W L S V E T H L L Y I I H G P V M A A L V V N F F F L L N I V R V L V T K M R E T H E A E S H M Y L K A V K A T M I L V P L L G I Q F V V F P W R P S N K M L G K I Y D Y V M H S L I H F Q G F F V A T I Y C F C N N E V Q T T V K R Q W A Q F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7TYF	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Amylin	-	Gs/β1/γ2; RAMP1	2.2	2022-03-23	doi.org/10.1126/science.abm9609
	7TYF (No Gprot)	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Amylin	-		2.2	2022-03-23	doi.org/10.1126/science.abm9609
	7TYW	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Calcitonin-1	-	Gs/β1/γ2; RAMP1	3	2022-03-23	doi.org/10.1126/science.abm9609
	7TYW (No Gprot)	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Calcitonin-1	-		3	2022-03-23	doi.org/10.1126/science.abm9609
	9AUC	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Calcitonin gene-related peptide-1	-	Gs/β1/γ2; RAMP1	2.4	2024-04-24	doi.org/10.1021/acs.biochem.4c00114
	9AUC (No Gprot)	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Calcitonin gene-related peptide-1	-		2.4	2024-04-24	doi.org/10.1021/acs.biochem.4c00114
	9BLW	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Cagrilintide (non-acylated)	-	Gs/β1/γ2; RAMP1	3.2	2025-04-16	doi.org/10.1038/s41467-025-58680-y
	9BLW (No Gprot)	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Cagrilintide (non-acylated)	-		3.2	2025-04-16	doi.org/10.1038/s41467-025-58680-y
	9BP3	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Cagrilintide	-	Gs/β1/γ2; RAMP1	2.2	2025-04-23	doi.org/10.1038/s41467-025-58680-y
	9BP3 (No Gprot)	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Cagrilintide	-		2.2	2025-04-23	doi.org/10.1038/s41467-025-58680-y

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