psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	E:E:C27	E:E:L80	3.17	No	No	0	9	5
2	E:E:C27	E:E:C82	7.28	No	No	0	9	9
3	E:E:N86	E:E:Q28	14.52	No	No	0	8	4
4	E:E:A87	E:E:Q28	4.55	No	No	0	4	4
5	E:E:T73	E:E:Y32	4.99	Yes	Yes	0	9	7
6	E:E:M76	E:E:Y32	13.17	No	Yes	0	6	7
7	E:E:C82	E:E:Y32	5.38	No	Yes	0	9	7
8	E:E:E38	E:E:L35	3.98	No	No	0	4	3
9	E:E:L36	E:E:M76	4.24	No	No	0	7	6
10	E:E:F92	E:E:L36	9.74	No	No	0	8	7
11	E:E:E38	E:E:R37	11.63	No	No	0	4	4
12	E:E:F92	E:E:R37	3.21	No	No	0	8	4
13	E:E:C40	E:E:L39	4.76	No	No	7	9	2
14	E:E:C72	E:E:L39	3.17	No	No	7	9	2
15	E:E:C40	E:E:C72	5.46	No	No	7	9	9
16	E:E:L41	E:E:V96	7.45	No	No	0	7	7
17	E:E:D47	E:E:F44	8.36	Yes	No	0	6	9
18	E:E:F44	E:E:L69	14.61	No	No	0	9	8
19	E:E:M48	E:E:Q45	4.08	Yes	No	8	9	4
20	E:E:E49	E:E:Q45	8.92	No	No	8	4	4
21	E:E:D47	E:E:V51	4.38	Yes	No	0	6	6
22	E:E:D47	E:E:S65	8.83	Yes	No	0	6	5
23	E:E:E49	E:E:M48	4.06	No	Yes	8	4	9
24	E:E:M48	E:E:Y100	23.95	Yes	No	0	9	9
25	E:E:E53	E:E:Y100	5.61	No	No	0	4	9
26	E:E:L55	E:E:T54	7.37	No	No	0	4	3
27	E:E:F101	E:E:W56	3.01	Yes	No	0	9	9
28	E:E:C104	E:E:C57	7.28	No	No	0	9	9
29	E:E:G60	E:E:W59	4.22	No	No	0	3	9
30	E:E:W59	R:R:Y53	6.75	No	Yes	0	9	1
31	E:E:G60	E:E:R61	4.5	No	No	0	3	5
32	E:E:S65	E:E:T62	3.2	No	No	0	5	9
33	E:E:E68	E:E:R64	6.98	No	No	0	4	3
34	E:E:F93	E:E:Y66	14.44	Yes	Yes	4	9	9
35	E:E:H97	E:E:Y66	13.07	Yes	Yes	4	9	9
36	E:E:Y66	R:R:M49	4.79	Yes	No	0	9	4
37	E:E:Y66	R:R:Q52	5.64	Yes	No	0	9	6
38	E:E:Y66	R:R:Y53	19.86	Yes	Yes	4	9	1
39	E:E:R67	R:R:M49	4.96	No	No	0	3	4
40	E:E:D71	E:E:H75	8.82	Yes	No	0	8	4
41	E:E:T73	E:E:W84	12.13	Yes	No	0	9	9
42	E:E:T73	E:E:V89	3.17	Yes	No	0	9	9
43	E:E:E78	E:E:W74	4.36	No	No	0	1	1
44	E:E:W74	E:E:W84	21.56	No	No	0	1	9
45	E:E:F83	R:R:N124	6.04	No	No	1	5	5
46	E:E:F83	R:R:R126	7.48	No	Yes	1	5	4
47	E:E:P85	E:E:W84	17.57	No	No	0	9	9
48	E:E:P85	R:R:W76	6.76	No	No	0	9	8
49	E:E:P85	R:R:G78	4.06	No	No	0	9	5
50	E:E:N86	R:R:R126	6.03	No	Yes	0	8	4
51	E:E:E88	E:E:R91	6.98	No	No	0	4	3
52	E:E:E88	E:E:F92	4.66	No	No	0	4	8
53	E:E:A95	E:E:R91	4.15	No	No	0	4	3
54	E:E:F93	E:E:V96	3.93	Yes	No	4	9	7
55	E:E:F93	E:E:H97	16.97	Yes	Yes	4	9	9
56	E:E:F93	R:R:Y56	20.63	Yes	Yes	4	9	3
57	E:E:L94	R:R:Y56	8.21	No	Yes	0	5	3
58	E:E:L94	R:R:M59	7.07	No	No	0	5	5
59	E:E:H97	E:E:V96	6.92	Yes	No	4	9	7
60	E:E:F101	E:E:H97	13.58	Yes	Yes	4	9	9
61	E:E:H97	R:R:Y53	11.98	Yes	Yes	4	9	1
62	E:E:H97	R:R:Y56	10.89	Yes	Yes	4	9	3
63	E:E:F101	E:E:Y100	14.44	Yes	No	0	9	9
64	E:E:F101	R:R:Y53	9.28	Yes	Yes	4	9	1
65	E:E:C104	E:E:P105	3.77	No	No	0	9	6
66	E:E:I106	R:R:K54	11.63	No	No	0	4	4
67	E:E:I123	E:E:L119	7.14	No	No	0	9	9
68	E:E:L119	E:E:V124	2.98	No	No	0	9	4
69	E:E:V125	E:E:Y120	3.79	No	No	0	6	6
70	E:E:F122	E:E:P121	5.78	No	No	0	8	8
71	E:E:I123	R:R:Y299	6.04	No	No	0	9	7
72	E:E:P126	E:E:V125	3.53	No	No	0	9	6
73	E:E:P126	R:R:P304	3.9	No	Yes	0	9	9
74	E:E:I127	R:R:A307	4.87	No	No	0	6	3
75	E:E:T130	R:R:F269	7.78	No	Yes	0	9	3
76	E:E:T130	R:R:P304	6.99	No	Yes	0	9	9
77	E:E:V133	R:R:F269	10.49	No	Yes	0	7	3
78	E:E:T134	R:R:L238	7.37	No	Yes	0	9	8
79	E:E:V137	R:R:I242	4.61	No	Yes	0	9	7
80	E:E:V137	R:R:L265	8.94	No	Yes	0	9	7
81	E:E:V138	R:R:I242	7.68	No	Yes	0	9	7
82	E:E:Q140	E:E:W139	7.67	No	No	5	8	9
83	E:E:K142	E:E:W139	3.48	No	No	0	8	9
84	E:E:R143	E:E:W139	5	No	No	5	6	9
85	E:E:Q140	E:E:R143	5.84	No	No	5	8	6
86	E:E:Q140	R:R:W261	24.09	No	Yes	5	8	2
87	E:E:S141	R:R:T246	9.59	No	Yes	0	9	7
88	E:E:K142	R:R:V250	3.04	No	No	0	8	5
89	H:H:?1	R:R:H121	4.61	Yes	Yes	1	0	4
90	H:H:?1	R:R:W128	7.15	Yes	Yes	1	0	5
91	H:H:?1	R:R:N130	24.64	Yes	Yes	1	0	8
92	H:H:?1	R:R:T132	3.97	Yes	No	1	0	6
93	H:H:?1	R:R:M133	10.15	Yes	Yes	1	0	5
94	H:H:?2	R:R:Y65	4.21	No	Yes	9	0	3
95	H:H:?2	R:R:Y71	6.31	No	No	9	0	3
96	H:H:?2	R:R:N73	34.5	No	No	0	0	4
97	L:L:C1	L:L:L4	3.17	Yes	No	0	0	0
98	L:L:C1	L:L:C7	7.28	Yes	No	2	0	0
99	L:L:C1	R:R:L298	3.17	Yes	Yes	2	0	6
100	L:L:C1	R:R:H302	11.79	Yes	Yes	2	0	6
101	L:L:N3	L:L:S2	4.47	No	Yes	0	0	0
102	L:L:K11	L:L:S2	6.12	No	Yes	0	0	0
103	L:L:S2	R:R:V293	3.23	Yes	No	0	0	6
104	L:L:S2	R:R:E294	8.62	Yes	No	0	0	3
105	L:L:N3	R:R:W361	14.69	No	No	0	0	4
106	L:L:L4	L:L:T6	4.42	No	Yes	0	0	0
107	L:L:L4	R:R:M306	5.65	No	No	0	0	4
108	L:L:S5	R:R:F356	7.93	No	Yes	0	0	7
109	L:L:S5	R:R:M376	3.07	No	Yes	0	0	7
110	L:L:T6	R:R:Y234	3.75	Yes	Yes	2	0	7
111	L:L:T6	R:R:H302	8.21	Yes	Yes	2	0	6
112	L:L:T6	R:R:V305	3.17	Yes	No	2	0	7
113	L:L:C7	R:R:H302	7.37	No	Yes	2	0	6
114	L:L:V8	R:R:H377	5.54	No	Yes	0	0	7
115	L:L:L9	R:R:I198	7.14	No	Yes	0	0	7
116	L:L:L9	R:R:H226	3.86	No	No	0	0	6
117	L:L:K11	L:L:Q14	5.42	No	Yes	0	0	0
118	L:L:E15	L:L:K11	9.45	No	No	0	0	0
119	L:L:L12	R:R:H377	7.71	No	Yes	0	0	7
120	L:L:S13	R:R:V206	3.23	No	No	0	0	3
121	L:L:K18	L:L:Q14	4.07	Yes	Yes	0	0	0
122	L:L:Q14	R:R:V293	5.73	Yes	No	0	0	6
123	L:L:Q14	R:R:E294	10.19	Yes	No	0	0	3
124	L:L:E15	L:L:K18	6.75	No	Yes	0	0	0
125	L:L:L16	R:R:Y146	9.38	Yes	No	0	0	2
126	L:L:L16	R:R:Y149	5.86	Yes	Yes	0	0	5
127	L:L:L16	R:R:V206	4.47	Yes	No	0	0	3
128	L:L:H17	L:L:T21	12.32	Yes	No	3	0	0
129	L:L:H17	L:L:Y22	6.53	Yes	Yes	3	0	0
130	L:L:H17	R:R:V212	11.07	Yes	No	3	0	3
131	L:L:H17	R:R:L291	7.71	Yes	No	3	0	6
132	L:L:K18	L:L:Y22	3.58	Yes	Yes	0	0	0
133	L:L:K18	R:R:P100	5.02	Yes	Yes	0	0	4
134	L:L:Q20	R:R:L142	10.65	No	No	0	0	2
135	L:L:Q20	R:R:Y146	10.15	No	No	0	0	2
136	L:L:T21	L:L:Y22	4.99	No	Yes	3	0	0
137	L:L:T21	R:R:G209	3.64	No	No	0	0	3
138	L:L:P23	L:L:Y22	4.17	No	Yes	0	0	0
139	L:L:Y22	R:R:P38	4.17	Yes	No	3	0	5
140	L:L:Y22	R:R:L40	3.52	Yes	No	0	0	5
141	L:L:Y22	R:R:Y41	8.94	Yes	No	3	0	3
142	L:L:T25	L:L:T27	3.14	Yes	No	0	0	0
143	L:L:T25	R:R:F99	7.78	Yes	Yes	1	0	5
144	L:L:T25	R:R:D101	5.78	Yes	No	0	0	4
145	L:L:T25	R:R:F102	6.49	Yes	Yes	1	0	4
146	L:L:T27	R:R:N135	8.77	No	No	0	0	3
147	L:L:S29	R:R:E123	14.37	No	No	0	0	4
148	L:L:?33	L:L:P32	12.19	Yes	Yes	1	0	0
149	L:L:P32	R:R:D77	8.05	Yes	Yes	1	0	9
150	L:L:P32	R:R:G78	4.06	Yes	No	1	0	5
151	L:L:P32	R:R:W79	20.27	Yes	Yes	1	0	6
152	L:L:P32	R:R:Y131	5.56	Yes	Yes	1	0	5
153	L:L:?33	R:R:D77	6.72	Yes	Yes	1	0	9
154	L:L:?33	R:R:W128	8.46	Yes	Yes	1	0	5
155	L:L:?33	R:R:S129	7.43	Yes	Yes	1	0	7
156	L:L:?33	R:R:Y131	8.7	Yes	Yes	1	0	5
157	R:R:P38	R:R:Y41	8.34	No	No	3	5	3
158	R:R:F39	R:R:V43	5.24	No	No	0	4	2
159	R:R:D287	R:R:F39	7.17	Yes	No	0	3	4
160	R:R:L40	R:R:P100	9.85	No	Yes	0	5	4
161	R:R:P100	R:R:Y41	8.34	Yes	No	0	4	3
162	R:R:K46	R:R:V42	3.04	No	No	0	4	1
163	R:R:K46	R:R:V43	9.11	No	No	0	4	2
164	R:R:M48	R:R:R45	6.2	No	No	0	6	7
165	R:R:F99	R:R:R45	9.62	Yes	No	0	5	7
166	R:R:M48	R:R:W79	4.65	No	Yes	0	6	6
167	R:R:M48	R:R:Y98	19.16	No	Yes	0	6	4
168	R:R:Q52	R:R:W76	16.43	No	No	0	6	8
169	R:R:D57	R:R:K54	4.15	No	No	0	4	4
170	R:R:C55	R:R:C81	7.28	No	No	0	9	9
171	R:R:Q60	R:R:Y56	19.16	Yes	Yes	0	3	3
172	R:R:D57	R:R:Q60	3.92	No	Yes	0	4	3
173	R:R:D57	R:R:Q61	13.05	No	No	0	4	3
174	R:R:D83	R:R:R58	7.15	No	No	0	5	3
175	R:R:M59	R:R:R74	11.17	No	No	0	5	4
176	R:R:L62	R:R:P63	6.57	No	No	0	3	1
177	R:R:L62	R:R:R74	3.64	No	No	0	3	4
178	R:R:D84	R:R:L62	4.07	No	No	0	4	3
179	R:R:Q66	R:R:Y65	3.38	No	Yes	0	1	3
180	R:R:G67	R:R:Y65	5.79	No	Yes	0	2	3
181	R:R:Y65	R:R:Y71	41.7	Yes	No	9	3	3
182	R:R:D84	R:R:Y65	16.09	No	Yes	0	4	3
183	R:R:P86	R:R:Y65	5.56	No	Yes	0	2	3
184	R:R:E68	R:R:G69	4.91	No	No	0	1	1
185	R:R:G69	R:R:P70	4.06	No	No	0	1	1
186	R:R:C112	R:R:C72	7.28	No	No	1	9	9
187	R:R:C72	R:R:W118	16.98	No	Yes	1	9	9
188	R:R:D83	R:R:R74	11.91	No	No	0	5	4
189	R:R:K110	R:R:T75	4.5	Yes	No	1	8	5
190	R:R:T75	R:R:W118	12.13	No	Yes	1	5	9
191	R:R:C81	R:R:W76	5.22	No	No	0	9	8
192	R:R:D77	R:R:G78	5.03	Yes	No	1	9	5
193	R:R:D77	R:R:W82	8.93	Yes	Yes	0	9	9
194	R:R:D77	R:R:S129	8.83	Yes	Yes	1	9	7
195	R:R:D77	R:R:Y131	6.9	Yes	Yes	1	9	5
196	R:R:P96	R:R:W79	4.05	Yes	Yes	1	9	6
197	R:R:F99	R:R:W79	17.04	Yes	Yes	1	5	6
198	R:R:F102	R:R:W79	5.01	Yes	Yes	1	4	6
199	R:R:W79	R:R:Y131	19.29	Yes	Yes	1	6	5
200	R:R:L80	R:R:P96	8.21	No	Yes	1	5	9
201	R:R:L80	R:R:Y98	4.69	No	Yes	1	5	4
202	R:R:Q93	R:R:W82	5.48	No	Yes	0	6	9
203	R:R:V108	R:R:W82	3.68	No	Yes	0	7	9
204	R:R:K110	R:R:W82	20.89	Yes	Yes	0	8	9
205	R:R:P86	R:R:T85	5.25	No	No	0	2	7
206	R:R:S91	R:R:T85	9.59	No	No	0	5	7
207	R:R:L90	R:R:T109	5.9	No	No	0	4	5
208	R:R:L90	R:R:Y111	9.38	No	Yes	0	4	4
209	R:R:K107	R:R:Y92	11.94	No	No	0	3	4
210	R:R:T109	R:R:Y92	6.24	No	No	0	5	4
211	R:R:C134	R:R:C95	7.28	No	No	0	9	9
212	R:R:P96	R:R:Y98	6.95	Yes	Yes	1	9	4
213	R:R:F102	R:R:P96	5.78	Yes	Yes	1	4	9
214	R:R:P96	R:R:Y131	4.17	Yes	Yes	1	9	5
215	R:R:F102	R:R:F99	11.79	Yes	Yes	1	4	5
216	R:R:D101	R:R:P100	4.83	No	Yes	0	4	4
217	R:R:F102	R:R:Y131	3.09	Yes	Yes	1	4	5
218	R:R:C134	R:R:F102	5.59	No	Yes	0	9	4
219	R:R:F102	R:R:N135	4.83	Yes	No	0	4	3
220	R:R:D103	R:R:S105	4.42	Yes	No	0	3	1
221	R:R:D103	R:R:E106	3.9	Yes	No	0	3	4
222	R:R:D103	R:R:K141	5.53	Yes	No	0	3	3
223	R:R:E106	R:R:M133	8.12	No	Yes	0	4	5
224	R:R:K107	R:R:M133	11.52	No	Yes	0	3	5
225	R:R:V108	R:R:Y131	6.31	No	Yes	0	7	5
226	R:R:N130	R:R:T109	5.85	Yes	No	0	8	5
227	R:R:K110	R:R:W118	18.57	Yes	Yes	1	8	9
228	R:R:K110	R:R:T127	7.51	Yes	No	1	8	4
229	R:R:K110	R:R:S129	6.12	Yes	Yes	1	8	7
230	R:R:D113	R:R:Y111	12.64	No	Yes	0	5	4
231	R:R:F119	R:R:Y111	10.32	No	Yes	0	4	4
232	R:R:C112	R:R:W118	7.84	No	Yes	1	9	9
233	R:R:D113	R:R:E114	15.59	No	No	0	5	2
234	R:R:K115	R:R:V117	3.04	No	No	0	5	5
235	R:R:T127	R:R:W118	3.64	No	Yes	1	4	9
236	R:R:K120	R:R:N125	9.79	No	No	0	1	7
237	R:R:H121	R:R:P122	9.15	Yes	No	0	4	5
238	R:R:E123	R:R:H121	7.39	No	Yes	0	4	4
239	R:R:H121	R:R:W128	14.81	Yes	Yes	1	4	5
240	R:R:N124	R:R:R126	4.82	No	Yes	1	5	4
241	R:R:R126	R:R:T127	10.35	Yes	No	1	4	4
242	R:R:N130	R:R:W128	4.52	Yes	Yes	1	8	5
243	R:R:S129	R:R:Y131	7.63	Yes	Yes	1	7	5
244	R:R:N130	R:R:T132	7.31	Yes	No	1	8	6
245	R:R:M133	R:R:N130	4.21	Yes	Yes	1	5	8
246	R:R:P139	R:R:T138	5.25	No	No	0	3	2
247	R:R:Y146	R:R:Y150	4.96	No	No	0	2	4
248	R:R:V147	R:R:Y374	6.31	No	No	0	4	6
249	R:R:D373	R:R:L148	5.43	No	No	0	5	5
250	R:R:L148	R:R:Y374	9.38	No	No	0	5	6
251	R:R:Y149	R:R:Y150	8.94	Yes	No	0	5	4
252	R:R:I153	R:R:Y149	6.04	No	Yes	0	7	5
253	R:R:L202	R:R:Y149	8.21	No	Yes	0	7	5
254	R:R:L151	R:R:S378	3	No	No	0	5	5
255	R:R:A152	R:R:H381	7.32	No	No	0	7	9
256	R:R:F382	R:R:G155	9.03	No	No	0	7	8
257	R:R:H156	R:R:S195	8.37	No	Yes	0	7	7
258	R:R:H156	R:R:I198	9.28	No	Yes	0	7	7
259	R:R:H156	R:R:H381	13.14	No	No	0	7	9
260	R:R:S159	R:R:S195	3.26	No	Yes	0	9	7
261	R:R:G384	R:R:S159	3.71	No	No	0	9	9
262	R:R:I160	R:R:I192	4.42	No	Yes	0	5	7
263	R:R:I160	R:R:S195	7.74	No	Yes	0	5	7
264	R:R:F385	R:R:T162	9.08	Yes	No	0	5	6
265	R:R:A388	R:R:T162	3.36	No	No	0	8	6
266	R:R:F188	R:R:L163	6.09	No	No	0	8	8
267	R:R:I192	R:R:L163	5.71	Yes	No	0	7	8
268	R:R:A388	R:R:L163	3.15	No	No	0	8	8
269	R:R:F393	R:R:I165	3.77	No	No	0	8	5
270	R:R:A388	R:R:S166	3.42	No	No	0	8	9
271	R:R:C392	R:R:S166	6.89	No	No	0	9	9
272	R:R:F393	R:R:S166	3.96	No	No	0	8	9
273	R:R:F173	R:R:I169	3.77	Yes	No	0	7	8
274	R:R:C392	R:R:I169	3.27	No	No	0	9	8
275	R:R:F170	R:R:V181	11.8	Yes	No	0	8	9
276	R:R:F170	R:R:H184	3.39	Yes	No	0	8	9
277	R:R:F170	R:R:K185	4.96	Yes	No	0	8	6
278	R:R:F170	R:R:F188	6.43	Yes	No	0	8	8
279	R:R:C392	R:R:F170	6.98	No	Yes	0	9	8
280	R:R:F172	R:R:F173	5.36	No	Yes	0	2	7
281	R:R:F173	R:R:T401	3.89	Yes	No	0	7	7
282	R:R:F173	R:R:V402	3.93	Yes	No	0	7	5
283	R:R:F173	R:R:Q405	5.86	Yes	No	0	7	4
284	R:R:L176	R:R:V398	4.47	No	No	0	9	9
285	R:R:Q179	R:R:Y243	7.89	No	Yes	0	7	8
286	R:R:K256	R:R:Q179	8.14	No	No	0	5	7
287	R:R:L259	R:R:Q179	6.65	Yes	No	0	5	7
288	R:R:R180	R:R:V181	3.92	No	No	0	9	9
289	R:R:H184	R:R:R180	6.77	No	No	0	9	9
290	R:R:L183	R:R:W236	3.42	Yes	Yes	0	8	9
291	R:R:E240	R:R:L183	3.98	Yes	Yes	0	9	8
292	R:R:L183	R:R:Y243	5.86	Yes	Yes	0	8	8
293	R:R:L183	R:R:L259	4.15	Yes	Yes	0	8	5
294	R:R:E240	R:R:H184	8.62	Yes	No	0	9	9
295	R:R:N186	R:R:W236	11.3	No	Yes	2	9	9
296	R:R:N186	R:R:Y263	5.81	No	No	2	9	5
297	R:R:M187	R:R:Y191	5.99	No	Yes	0	8	8
298	R:R:E240	R:R:M187	10.83	Yes	No	0	9	8
299	R:R:F188	R:R:V387	3.93	No	No	0	8	9
300	R:R:L189	R:R:L193	5.54	No	No	0	3	6
301	R:R:L189	R:R:W267	4.56	No	Yes	0	3	9
302	R:R:T190	R:R:Y191	3.75	No	Yes	2	9	8
303	R:R:N233	R:R:T190	8.77	Yes	No	2	9	9
304	R:R:T190	R:R:W236	4.85	No	Yes	2	9	9
305	R:R:N233	R:R:Y191	13.96	Yes	Yes	2	9	8
306	R:R:M237	R:R:Y191	5.99	No	Yes	2	9	8
307	R:R:Q383	R:R:Y191	13.53	Yes	Yes	2	9	8
308	R:R:G384	R:R:Y191	5.79	No	Yes	0	9	8
309	R:R:V387	R:R:Y191	6.31	No	Yes	0	9	8
310	R:R:L193	R:R:M229	7.07	No	No	0	6	4
311	R:R:I198	R:R:N194	7.08	Yes	No	0	7	8
312	R:R:N194	R:R:N233	8.17	No	Yes	0	8	9
313	R:R:H201	R:R:V205	9.69	No	No	0	6	7
314	R:R:L211	R:R:V205	2.98	Yes	No	0	1	7
315	R:R:P207	R:R:V206	3.53	No	No	0	3	3
316	R:R:E210	R:R:N208	10.52	No	No	0	3	3
317	R:R:L211	R:R:N208	8.24	Yes	No	0	1	3
318	R:R:G209	R:R:R213	4.5	No	No	0	3	2
319	R:R:L211	R:R:P216	6.57	Yes	No	3	1	4
320	R:R:C219	R:R:L211	3.17	No	Yes	3	9	1
321	R:R:C289	R:R:V212	8.54	No	No	3	9	3
322	R:R:L291	R:R:V212	2.98	No	No	3	6	3
323	R:R:P216	R:R:R214	10.09	No	No	0	4	4
324	R:R:D215	R:R:K220	8.3	No	No	0	6	7
325	R:R:D215	R:R:N288	14.81	No	No	0	6	4
326	R:R:C219	R:R:P216	5.65	No	No	3	9	4
327	R:R:C219	R:R:C289	7.28	No	No	3	9	9
328	R:R:K220	R:R:N286	9.79	No	No	13	7	7
329	R:R:K220	R:R:W290	20.89	No	Yes	13	7	9
330	R:R:H223	R:R:Q227	11.13	No	Yes	0	5	7
331	R:R:H223	R:R:W290	10.58	No	Yes	0	5	9
332	R:R:F224	R:R:F225	3.22	No	No	0	5	5
333	R:R:F224	R:R:T274	5.19	No	No	0	5	6
334	R:R:H226	R:R:Q227	4.95	No	Yes	0	6	7
335	R:R:H226	R:R:M230	5.25	No	No	0	6	6
336	R:R:I301	R:R:Q227	6.86	No	Yes	0	7	7
337	R:R:H302	R:R:Q227	4.95	Yes	Yes	0	6	7
338	R:R:C232	R:R:Y228	9.41	No	No	0	8	8
339	R:R:L271	R:R:Y228	5.86	No	No	0	4	8
340	R:R:M229	R:R:W267	4.65	No	Yes	0	4	9
341	R:R:M230	R:R:Y234	4.79	No	Yes	0	6	7
342	R:R:C232	R:R:W267	3.92	No	Yes	0	8	9
343	R:R:C232	R:R:P270	7.53	No	Yes	0	8	9
344	R:R:N233	R:R:Y234	3.49	Yes	Yes	2	9	7
345	R:R:M237	R:R:Y234	3.59	No	Yes	2	9	7
346	R:R:V305	R:R:Y234	7.57	No	Yes	2	7	7
347	R:R:F356	R:R:Y234	12.38	Yes	Yes	2	7	7
348	R:R:F235	R:R:L265	3.65	Yes	Yes	6	5	7
349	R:R:F235	R:R:F269	8.57	Yes	Yes	6	5	3
350	R:R:F235	R:R:P270	5.78	Yes	Yes	6	5	9
351	R:R:A308	R:R:F235	4.16	No	Yes	0	7	5
352	R:R:C239	R:R:W236	6.53	No	Yes	0	7	9
353	R:R:W236	R:R:Y263	3.86	Yes	No	2	9	5
354	R:R:G266	R:R:W236	8.44	No	Yes	0	9	9
355	R:R:W236	R:R:W267	14.99	Yes	Yes	0	9	9
356	R:R:M237	R:R:Q383	5.44	No	Yes	2	9	9
357	R:R:I242	R:R:L238	7.14	Yes	Yes	0	7	8
358	R:R:A308	R:R:L238	3.15	No	Yes	0	7	8
359	R:R:L238	R:R:V311	2.98	Yes	No	0	8	6
360	R:R:L238	R:R:N312	8.24	Yes	No	0	8	9
361	R:R:C239	R:R:L265	4.76	No	Yes	0	7	7
362	R:R:E240	R:R:L351	9.28	Yes	No	0	9	9
363	R:R:I242	R:R:Y262	4.84	Yes	Yes	0	7	7
364	R:R:F315	R:R:I242	3.77	No	Yes	0	8	7
365	R:R:L247	R:R:Y243	8.21	No	Yes	0	8	8
366	R:R:Q257	R:R:Y243	7.89	No	Yes	12	5	8
367	R:R:Y243	R:R:Y262	4.96	Yes	Yes	12	8	7
368	R:R:I319	R:R:L244	7.14	No	No	0	9	9
369	R:R:H245	R:R:V249	9.69	Yes	No	0	8	6
370	R:R:H245	R:R:V250	4.15	Yes	No	0	8	5
371	R:R:F315	R:R:H245	26.02	No	Yes	0	8	8
372	R:R:H245	R:R:N318	7.65	Yes	No	0	8	8
373	R:R:T246	R:R:V250	6.35	Yes	No	0	7	5
374	R:R:Q257	R:R:T246	7.09	No	Yes	0	5	7
375	R:R:I248	R:R:L247	4.28	Yes	No	0	7	8
376	R:R:I248	R:R:V249	3.07	Yes	No	0	7	6
377	R:R:I248	R:R:V322	4.61	Yes	No	0	7	8
378	R:R:A251	R:R:T254	5.03	No	No	0	6	6
379	R:R:Q257	R:R:Y262	4.51	No	Yes	12	5	7
380	R:R:R258	R:R:R260	5.33	No	No	5	5	3
381	R:R:R258	R:R:W261	3	No	Yes	5	5	2
382	R:R:L259	R:R:Y262	4.69	Yes	Yes	0	5	7
383	R:R:L259	R:R:Y263	4.69	Yes	No	0	5	5
384	R:R:R260	R:R:W261	6	No	Yes	5	3	2
385	R:R:F269	R:R:L265	3.65	Yes	Yes	6	3	7
386	R:R:F269	R:R:P270	4.33	Yes	Yes	6	3	9
387	R:R:P273	R:R:V272	3.53	No	No	0	6	4
388	R:R:I276	R:R:I300	4.42	No	No	0	5	8
389	R:R:H277	R:R:R281	10.16	No	Yes	0	7	7
390	R:R:H277	R:R:L298	5.14	No	Yes	0	7	6
391	R:R:H277	R:R:I301	13.26	No	No	0	7	7
392	R:R:T280	R:R:Y284	3.75	No	No	0	4	2
393	R:R:L297	R:R:T280	4.42	No	No	0	4	4
394	R:R:D287	R:R:R281	5.96	Yes	Yes	0	3	7
395	R:R:R281	R:R:W290	17.99	Yes	Yes	0	7	9
396	R:R:R281	R:R:T295	5.17	Yes	No	0	7	4
397	R:R:V283	R:R:Y284	6.31	No	No	0	3	2
398	R:R:D287	R:R:F285	10.75	Yes	No	0	3	6
399	R:R:F285	R:R:T295	9.08	No	No	0	6	4
400	R:R:N286	R:R:W290	6.78	No	Yes	13	7	9
401	R:R:D287	R:R:S292	4.42	Yes	No	0	3	4
402	R:R:C289	R:R:L291	3.17	No	No	3	9	6
403	R:R:L298	R:R:V293	2.98	Yes	No	0	6	6
404	R:R:L297	R:R:T295	5.9	No	No	0	4	4
405	R:R:H296	R:R:Y299	6.53	No	No	0	2	7
406	R:R:H302	R:R:L298	6.43	Yes	Yes	2	6	6
407	R:R:F356	R:R:L309	3.65	Yes	No	0	7	7
408	R:R:F315	R:R:V311	7.87	No	No	0	8	6
409	R:R:L352	R:R:N312	4.12	No	No	0	9	9
410	R:R:F313	R:R:L317	3.65	No	No	0	6	5
411	R:R:F313	R:R:V357	9.18	No	No	0	6	7
412	R:R:L316	R:R:V320	2.98	No	No	0	9	7
413	R:R:L316	R:R:L348	4.15	No	No	0	9	9
414	R:R:I354	R:R:L316	5.71	No	No	0	6	9
415	R:R:N318	R:R:R321	4.82	No	No	0	8	8
416	R:R:T345	R:R:V320	4.76	No	No	0	9	7
417	R:R:K326	R:R:V322	3.04	No	No	0	9	8
418	R:R:E329	R:R:K326	5.4	No	No	0	6	9
419	R:R:E332	R:R:M327	4.06	No	No	0	5	7
420	R:R:M327	R:R:M337	5.78	No	No	0	7	7
421	R:R:K340	R:R:M327	5.76	No	No	0	8	7
422	R:R:E334	R:R:R328	3.49	No	No	14	6	6
423	R:R:M337	R:R:R328	6.2	No	No	14	7	6
424	R:R:E332	R:R:T330	7.06	No	No	0	5	5
425	R:R:E332	R:R:H336	6.15	No	No	0	5	6
426	R:R:E334	R:R:M337	8.12	No	No	14	6	7
427	R:R:E334	R:R:Y338	4.49	No	No	0	6	7
428	R:R:H336	R:R:K340	10.48	No	No	0	6	8
429	R:R:M346	R:R:T345	3.01	No	No	0	8	9
430	R:R:I347	R:R:I390	5.89	No	No	0	8	8
431	R:R:L348	R:R:Y391	4.69	No	No	0	9	8
432	R:R:P350	R:R:V349	5.3	No	No	0	9	8
433	R:R:I354	R:R:V349	7.68	No	No	0	6	8
434	R:R:L351	R:R:Y391	11.72	No	No	0	9	8
435	R:R:G353	R:R:Q355	4.93	No	No	2	9	8
436	R:R:F356	R:R:G353	3.01	Yes	No	2	7	9
437	R:R:F356	R:R:Q355	9.37	Yes	No	2	7	8
438	R:R:Q355	R:R:Q383	8.96	No	Yes	2	8	9
439	R:R:F356	R:R:I380	8.79	Yes	No	0	7	6
440	R:R:F356	R:R:Q383	4.68	Yes	Yes	2	7	9
441	R:R:F359	R:R:V358	6.55	Yes	No	0	6	5
442	R:R:F359	R:R:Y372	5.16	Yes	Yes	10	6	7
443	R:R:F359	R:R:M376	6.22	Yes	Yes	10	6	7
444	R:R:G369	R:R:R362	6	No	No	0	4	4
445	R:R:R362	R:R:Y372	7.2	No	Yes	0	4	7
446	R:R:D373	R:R:R362	14.29	No	No	0	5	4
447	R:R:L368	R:R:P363	3.28	No	No	0	3	7
448	R:R:P363	R:R:Y372	8.34	No	Yes	0	7	7
449	R:R:L368	R:R:N365	12.36	No	No	0	3	4
450	R:R:M376	R:R:Y372	14.37	Yes	Yes	10	7	7
451	R:R:L379	R:R:V375	2.98	No	No	0	5	4
452	R:R:H377	R:R:H381	9.55	Yes	No	0	7	9
453	R:R:F382	R:R:F385	5.36	No	Yes	11	7	5
454	R:R:F382	R:R:F386	3.22	No	No	11	7	5
455	R:R:F385	R:R:F386	4.29	Yes	No	11	5	5
456	R:R:F385	R:R:T389	7.78	Yes	No	0	5	5
457	R:R:F393	R:R:T389	5.19	No	No	0	8	5
458	R:R:I390	R:R:Y391	7.25	No	No	0	8	8
459	R:R:E397	R:R:N395	10.52	No	No	0	9	9
460	R:R:N395	R:R:V398	8.87	No	No	0	9	9
461	R:R:N396	R:R:Q399	6.6	No	No	0	6	7
462	R:R:R404	R:R:T400	3.88	No	No	0	7	4
463	R:R:I248	R:R:I319	2.94	Yes	No	0	7	9
464	L:L:N26	L:L:T31	2.92	No	No	0	0	0
465	R:R:I192	R:R:M196	2.92	Yes	No	0	7	4
466	E:E:G33	E:E:Y32	2.9	No	Yes	0	4	7
467	E:E:I127	E:E:L131	2.85	No	No	0	6	9
468	R:R:I192	R:R:L167	2.85	Yes	No	0	7	6
469	R:R:I198	R:R:L202	2.85	Yes	No	0	7	7
470	R:R:E204	R:R:V205	2.85	No	No	0	4	7
471	L:L:L19	R:R:K141	2.82	No	No	0	0	3
472	R:R:K143	R:R:N144	2.8	No	No	0	1	4
473	E:E:P121	E:E:Y120	2.78	No	No	0	8	6
474	E:E:D90	R:R:M59	2.77	No	No	0	9	5
475	R:R:A278	R:R:F224	2.77	No	No	0	6	5
476	E:E:R102	E:E:S103	2.64	No	No	0	4	5
477	E:E:E29	E:E:N31	2.63	No	No	0	4	1
478	R:R:F161	R:R:T162	2.59	No	No	0	4	6
479	R:R:A282	R:R:W290	2.59	No	Yes	0	3	9
480	R:R:H201	R:R:L222	2.57	No	No	0	6	6
481	E:E:V124	E:E:Y120	2.52	No	No	0	4	6
482	R:R:V203	R:R:Y149	2.52	No	Yes	0	3	5
483	R:R:F225	R:R:I221	2.51	No	No	0	5	4
484	R:R:F313	R:R:I354	2.51	No	No	0	6	6
485	R:R:T274	R:R:Y228	2.5	No	No	0	6	8
486	R:R:F170	R:R:L176	2.44	Yes	No	0	8	9
487	R:R:F314	R:R:L317	2.44	No	No	0	5	5
488	R:R:K47	R:R:Y98	2.39	No	Yes	0	4	4
489	E:E:D58	E:E:R61	2.38	No	No	0	7	5
490	E:E:R102	R:R:Q60	2.34	No	Yes	0	4	3
491	R:R:L264	R:R:W261	2.28	No	Yes	0	3	2
492	R:R:G116	R:R:P70	2.03	No	No	0	9	1
493	R:R:G268	R:R:P270	2.03	No	Yes	0	6	9
494	R:R:G303	R:R:P304	2.03	No	Yes	0	4	9
495	R:R:C178	R:R:G177	1.96	No	No	0	8	7
496	R:R:A87	R:R:G88	1.95	No	No	0	4	8
497	R:R:P273	R:R:P304	1.95	No	Yes	0	6	9
498	R:R:A231	R:R:P270	1.87	No	Yes	0	5	9
499	L:L:G10	L:L:S13	1.86	No	No	0	0	0
500	E:E:G52	E:E:V51	1.84	No	No	0	6	6
501	R:R:G44	R:R:V43	1.84	No	No	0	4	2
502	R:R:G88	R:R:V89	1.84	No	No	0	8	5
503	R:R:G168	R:R:V171	1.84	No	No	0	1	4
504	L:L:G28	L:L:T31	1.82	No	No	0	0	0
505	E:E:A77	E:E:C82	1.81	No	No	0	9	9
506	E:E:I127	R:R:G303	1.76	No	No	0	6	4
507	L:L:P32	L:L:T31	1.75	Yes	No	0	0	0
508	R:R:G241	R:R:L244	1.71	No	No	0	8	9
509	R:R:G241	R:R:L352	1.71	No	No	0	8	9
510	R:R:A341	R:R:V320	1.7	No	No	0	9	7
511	R:R:A341	R:R:V324	1.7	No	No	0	9	5
512	E:E:A70	E:E:T73	1.68	No	Yes	0	8	9
513	R:R:A251	R:R:T246	1.68	No	Yes	0	6	7
514	E:E:G98	R:R:Q60	1.64	No	Yes	0	3	3
515	R:R:D103	R:R:P104	1.61	Yes	No	0	3	3
516	E:E:V125	E:E:V129	1.6	No	No	0	6	6
517	R:R:V310	R:R:V357	1.6	No	No	0	4	7
518	E:E:T128	E:E:V129	1.59	No	No	0	6	6
519	R:R:T325	R:R:V324	1.59	No	No	0	7	5
520	E:E:P105	R:R:Q61	1.58	No	No	0	6	3
521	L:L:L16	R:R:A145	1.58	Yes	No	0	0	4
522	R:R:A344	R:R:L323	1.58	No	No	0	9	9
523	R:R:T400	R:R:T401	1.57	No	No	0	4	7
524	E:E:C72	E:E:D71	1.56	No	Yes	0	9	8
525	R:R:I153	R:R:S157	1.55	No	No	0	7	7
526	R:R:I199	R:R:S195	1.55	No	Yes	0	7	7
527	R:R:I165	R:R:V164	1.54	No	No	0	5	4
528	R:R:I192	R:R:V164	1.54	Yes	No	0	7	4
529	R:R:I221	R:R:V217	1.54	No	No	0	4	3
530	R:R:I276	R:R:V272	1.54	No	No	0	5	4
531	R:R:I279	R:R:T275	1.52	No	No	0	3	3
532	R:R:M346	R:R:V342	1.52	No	No	0	8	8
533	R:R:M376	R:R:V375	1.52	Yes	No	0	7	4
534	E:E:A30	E:E:E29	1.51	No	No	0	4	4
535	R:R:K141	R:R:T138	1.5	No	No	0	3	2
536	R:R:L158	R:R:V154	1.49	No	No	0	4	6
537	R:R:L259	R:R:T182	1.47	Yes	No	0	5	5
538	R:R:L271	R:R:T275	1.47	No	No	0	4	3
539	R:R:I197	R:R:M229	1.46	No	No	0	5	4
540	R:R:A333	R:R:H336	1.46	No	No	0	5	6
541	R:R:G88	R:R:Y111	1.45	No	Yes	0	8	4
542	R:R:I347	R:R:K343	1.45	No	No	0	8	8
543	R:R:F359	R:R:P360	1.44	Yes	No	0	6	5
544	E:E:I118	E:E:L119	1.43	No	No	0	6	9
545	R:R:I200	R:R:L222	1.43	No	No	0	6	6
546	R:R:E329	R:R:T330	1.41	No	No	0	6	5
547	R:R:K370	R:R:N144	1.4	No	No	0	4	4
548	R:R:M367	R:R:N365	1.4	No	No	0	4	4
549	E:E:D47	E:E:M48	1.39	Yes	Yes	0	6	9
550	R:R:A136	R:R:F137	1.39	No	No	0	2	1
551	R:R:D97	R:R:K47	1.38	No	No	0	2	4
552	R:R:D50	R:R:K54	1.38	No	No	0	2	4
553	E:E:D58	E:E:L55	1.36	No	No	0	7	4
554	R:R:E114	R:R:K115	1.35	No	No	0	2	5
555	R:R:A51	R:R:Y98	1.33	No	Yes	0	8	4
556	R:R:E397	R:R:N396	1.31	No	No	0	9	6
557	E:E:D71	E:E:E68	1.3	Yes	No	0	8	4
558	R:R:H377	R:R:L151	1.29	Yes	No	0	7	5
559	L:L:R24	R:R:N135	1.21	No	No	0	0	3
560	E:E:D71	E:E:R67	1.19	Yes	No	0	8	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	E:E:Y32	6.61	4	0	7
2	E:E:D47	5.74	4	0	6
3	E:E:M48	8.37	4	8	9
4	E:E:Y66	11.56	5	4	9
5	E:E:D71	3.2175	4	0	8
6	E:E:T73	5.4925	4	0	9
7	E:E:F93	13.9925	4	4	9
8	E:E:H97	12.235	6	4	9
9	E:E:F101	10.0775	4	4	9
10	H:H:?1	10.104	5	1	0
11	L:L:C1	6.3525	4	2	0
12	L:L:S2	5.61	4	0	0
13	L:L:T6	4.8875	4	2	0
14	L:L:Q14	6.3525	4	0	0
15	L:L:L16	5.3225	4	0	0
16	L:L:H17	9.4075	4	3	0
17	L:L:K18	4.855	4	0	0
18	L:L:Y22	5.12857	7	3	0
19	L:L:T25	5.7975	4	1	0
20	L:L:P32	8.64667	6	1	0
21	L:L:?33	8.7	5	1	0
22	R:R:Y53	11.9675	4	4	1
23	R:R:Y56	14.7225	4	4	3
24	R:R:Q60	6.765	4	0	3
25	R:R:Y65	12.7883	6	9	3
26	R:R:D77	7.41	6	1	9
27	R:R:W79	11.7183	6	1	6
28	R:R:W82	9.745	4	0	9
29	R:R:P96	5.832	5	1	9
30	R:R:Y98	6.904	5	1	4
31	R:R:F99	11.5575	4	1	5
32	R:R:P100	7.01	4	0	4
33	R:R:F102	6.08286	7	1	4
34	R:R:D103	3.865	4	0	3
35	R:R:K110	11.518	5	1	8
36	R:R:Y111	8.4475	4	0	4
37	R:R:W118	11.832	5	1	9
38	R:R:H121	8.99	4	1	4
39	R:R:R126	7.17	4	1	4
40	R:R:W128	8.735	4	1	5
41	R:R:S129	7.5025	4	1	7
42	R:R:N130	9.306	5	1	8
43	R:R:Y131	7.70625	8	1	5
44	R:R:M133	8.5	4	1	5
45	R:R:Y149	6.314	5	0	5
46	R:R:F170	6	6	0	8
47	R:R:F173	4.562	5	0	7
48	R:R:L183	4.3525	4	0	8
49	R:R:Y191	7.90286	7	2	8
50	R:R:I192	3.488	5	0	7
51	R:R:S195	5.23	4	0	7
52	R:R:I198	6.5875	4	0	7
53	R:R:L211	5.24	4	3	1
54	R:R:Q227	6.9725	4	0	7
55	R:R:N233	8.5975	4	2	9
56	R:R:Y234	5.92833	6	2	7
57	R:R:F235	5.54	4	6	5
58	R:R:W236	7.62714	7	2	9
59	R:R:L238	5.776	5	0	8
60	R:R:E240	8.1775	4	0	9
61	R:R:I242	5.608	5	0	7
62	R:R:Y243	6.962	5	12	8
63	R:R:H245	11.8775	4	0	8
64	R:R:T246	6.1775	4	0	7
65	R:R:I248	3.725	4	0	7
66	R:R:L259	4.33	5	0	5
67	R:R:W261	8.8425	4	5	2
68	R:R:Y262	4.75	4	12	7
69	R:R:L265	5.25	4	6	7
70	R:R:W267	7.03	4	0	9
71	R:R:F269	6.964	5	6	3
72	R:R:P270	4.308	5	6	9
73	R:R:R281	9.82	4	0	7
74	R:R:D287	7.075	4	0	3
75	R:R:W290	11.766	5	13	9
76	R:R:L298	4.43	4	2	6
77	R:R:H302	7.75	5	2	6
78	R:R:P304	3.7175	4	0	9
79	R:R:F356	7.11571	7	2	7
80	R:R:F359	4.8425	4	10	6
81	R:R:Y372	8.7675	4	10	7
82	R:R:M376	6.295	4	10	7
83	R:R:H377	6.0225	4	0	7
84	R:R:Q383	8.1525	4	2	9
85	R:R:F385	6.6275	4	11	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	E:E:T73	E:E:Y32	10.4541	4.99	Yes	Yes	0	9	7
2	E:E:T73	E:E:W84	12.5293	12.13	Yes	No	0	9	9
3	E:E:P85	E:E:W84	14.5992	17.57	No	No	0	9	9
4	E:E:P85	R:R:G78	91.8513	4.06	No	No	0	9	5
5	R:R:D77	R:R:G78	24.8921	5.03	Yes	No	1	9	5
6	E:E:P85	R:R:W76	78.064	6.76	No	No	0	9	8
7	R:R:Q52	R:R:W76	76.1623	16.43	No	No	0	6	8
8	E:E:Y66	R:R:Q52	75.5283	5.64	Yes	No	0	9	6
9	E:E:F93	E:E:Y66	22.8263	14.44	Yes	Yes	4	9	9
10	E:E:H97	E:E:Y66	32.2225	13.07	Yes	Yes	4	9	9
11	E:E:F101	E:E:Y100	16.265	14.44	Yes	No	0	9	9
12	E:E:M48	E:E:Y100	13.56	23.95	Yes	No	0	9	9
13	E:E:Y66	R:R:Y53	14.0992	19.86	Yes	Yes	4	9	1
14	R:R:D57	R:R:Q60	10.8573	3.92	No	Yes	0	4	3
15	R:R:Q60	R:R:Y56	16.272	19.16	Yes	Yes	0	3	3
16	E:E:F93	R:R:Y56	20.8374	20.63	Yes	Yes	4	9	3
17	E:E:H97	R:R:Y56	21.0272	10.89	Yes	Yes	4	9	3
18	E:E:L94	R:R:Y56	24.3767	8.21	No	Yes	0	5	3
19	E:E:L94	R:R:M59	23.0274	7.07	No	No	0	5	5
20	L:L:P32	R:R:G78	67.5795	4.06	Yes	No	1	0	5
21	L:L:P32	R:R:W79	45.0153	20.27	Yes	Yes	1	0	6
22	R:R:F99	R:R:W79	22.4905	17.04	Yes	Yes	1	5	6
23	L:L:T25	R:R:F99	22.7992	7.78	Yes	Yes	1	0	5
24	L:L:T25	R:R:D101	100	5.78	Yes	No	0	0	4
25	R:R:D101	R:R:P100	99.9609	4.83	No	Yes	0	4	4
26	L:L:K18	R:R:P100	87.3165	5.02	Yes	Yes	0	0	4
27	L:L:K18	L:L:Q14	84.5083	4.07	Yes	Yes	0	0	0
28	L:L:Q14	R:R:V293	83.1537	5.73	Yes	No	0	0	6
29	R:R:L298	R:R:V293	83.1622	2.98	Yes	No	0	6	6
30	R:R:H302	R:R:L298	79.004	6.43	Yes	Yes	2	6	6
31	L:L:T6	R:R:H302	71.424	8.21	Yes	Yes	2	0	6
32	L:L:T6	R:R:Y234	71.406	3.75	Yes	Yes	2	0	7
33	R:R:N233	R:R:Y234	52.6335	3.49	Yes	Yes	2	9	7
34	R:R:N233	R:R:T190	38.2955	8.77	Yes	No	2	9	9
35	R:R:T190	R:R:W236	39.9095	4.85	No	Yes	2	9	9
36	R:R:C239	R:R:W236	12.3739	6.53	No	Yes	0	7	9
37	R:R:C239	R:R:L265	12.1092	4.76	No	Yes	0	7	7
38	R:R:F102	R:R:W79	22.5954	5.01	Yes	Yes	1	4	6
39	L:L:T25	R:R:F102	76.9703	6.49	Yes	Yes	1	0	4
40	L:L:P32	R:R:Y131	22.6394	5.56	Yes	Yes	1	0	5
41	R:R:F102	R:R:Y131	53.5884	3.09	Yes	Yes	1	4	5
42	R:R:D77	R:R:Y131	22.4698	6.9	Yes	Yes	1	9	5
43	R:R:L183	R:R:W236	19.4394	3.42	Yes	Yes	0	8	9
44	R:R:L183	R:R:Y243	15.9657	5.86	Yes	Yes	0	8	8
45	R:R:I242	R:R:Y262	10.028	4.84	Yes	Yes	0	7	7
46	L:L:?33	R:R:W128	10.1822	8.46	Yes	Yes	1	0	5
47	R:R:M59	R:R:R74	20.327	11.17	No	No	0	5	4
48	R:R:L62	R:R:R74	16.272	3.64	No	No	0	3	4
49	R:R:D84	R:R:L62	13.5658	4.07	No	No	0	4	3
50	R:R:D84	R:R:Y65	12.2118	16.09	No	Yes	0	4	3
51	L:L:K18	L:L:Y22	10.4427	3.58	Yes	Yes	0	0	0
52	L:L:H17	L:L:Y22	18.8963	6.53	Yes	Yes	3	0	0
53	R:R:N233	R:R:Y191	15.4929	13.96	Yes	Yes	2	9	8
54	R:R:V387	R:R:Y191	18.2067	6.31	No	Yes	0	9	8
55	R:R:F188	R:R:V387	17.6855	3.93	No	No	0	8	9
56	R:R:M237	R:R:Y234	15.5357	3.59	No	Yes	2	9	7
57	R:R:M237	R:R:Y191	15.1818	5.99	No	Yes	2	9	8
58	R:R:F170	R:R:F188	10.0355	6.43	Yes	No	0	8	8
59	R:R:M187	R:R:Y191	12.703	5.99	No	Yes	0	8	8
60	R:R:E240	R:R:M187	12.2754	10.83	Yes	No	0	9	8
61	R:R:C219	R:R:C289	15.4322	7.28	No	No	3	9	9
62	R:R:C219	R:R:L211	11.2257	3.17	No	Yes	3	9	1
63	R:R:E240	R:R:L351	11.3231	9.28	Yes	No	0	9	9
64	R:R:L351	R:R:Y391	10.8141	11.72	No	No	0	9	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
E:E:P85	R:R:G78	4.06	0	No	No	9	5	2	1
H:H:?1	R:R:H121	4.61	1	Yes	Yes	0	4	2	2
H:H:?1	R:R:W128	7.15	1	Yes	Yes	0	5	2	1
H:H:?1	R:R:N130	24.64	1	Yes	Yes	0	8	2	2
L:L:C1	R:R:L298	3.17	2	Yes	Yes	0	6	0	1
L:L:C1	R:R:H302	11.79	2	Yes	Yes	0	6	0	1
L:L:S2	R:R:V293	3.23	0	Yes	No	0	6	0	1
L:L:S2	R:R:E294	8.62	0	Yes	No	0	3	0	1
L:L:N3	R:R:W361	14.69	0	No	No	0	4	0	1
L:L:L4	R:R:M306	5.65	0	No	No	0	4	0	1
L:L:S5	R:R:F356	7.93	0	No	Yes	0	7	0	1
L:L:S5	R:R:M376	3.07	0	No	Yes	0	7	0	1
L:L:T6	R:R:Y234	3.75	2	Yes	Yes	0	7	0	1
L:L:T6	R:R:H302	8.21	2	Yes	Yes	0	6	0	1
L:L:T6	R:R:V305	3.17	2	Yes	No	0	7	0	1
L:L:C7	R:R:H302	7.37	2	No	Yes	0	6	0	1
L:L:V8	R:R:H377	5.54	0	No	Yes	0	7	0	1
L:L:L9	R:R:I198	7.14	0	No	Yes	0	7	0	1
L:L:L9	R:R:H226	3.86	0	No	No	0	6	0	1
L:L:L12	R:R:H377	7.71	0	No	Yes	0	7	0	1
L:L:S13	R:R:V206	3.23	0	No	No	0	3	0	1
L:L:Q14	R:R:V293	5.73	0	Yes	No	0	6	0	1
L:L:Q14	R:R:E294	10.19	0	Yes	No	0	3	0	1
L:L:L16	R:R:Y146	9.38	0	Yes	No	0	2	0	1
L:L:L16	R:R:Y149	5.86	0	Yes	Yes	0	5	0	1
L:L:L16	R:R:V206	4.47	0	Yes	No	0	3	0	1
L:L:H17	R:R:V212	11.07	3	Yes	No	0	3	0	1
L:L:H17	R:R:L291	7.71	3	Yes	No	0	6	0	1
L:L:K18	R:R:P100	5.02	0	Yes	Yes	0	4	0	1
L:L:Q20	R:R:L142	10.65	0	No	No	0	2	0	1
L:L:Q20	R:R:Y146	10.15	0	No	No	0	2	0	1
L:L:T21	R:R:G209	3.64	3	No	No	0	3	0	1
L:L:Y22	R:R:P38	4.17	3	Yes	No	0	5	0	1
L:L:Y22	R:R:L40	3.52	3	Yes	No	0	5	0	1
L:L:Y22	R:R:Y41	8.94	3	Yes	No	0	3	0	1
L:L:T25	R:R:F99	7.78	1	Yes	Yes	0	5	0	1
L:L:T25	R:R:D101	5.78	1	Yes	No	0	4	0	1
L:L:T25	R:R:F102	6.49	1	Yes	Yes	0	4	0	1
L:L:T27	R:R:N135	8.77	0	No	No	0	3	0	1
L:L:S29	R:R:E123	14.37	0	No	No	0	4	0	1
L:L:P32	R:R:D77	8.05	1	Yes	Yes	0	9	0	1
L:L:P32	R:R:G78	4.06	1	Yes	No	0	5	0	1
L:L:P32	R:R:W79	20.27	1	Yes	Yes	0	6	0	1
L:L:P32	R:R:Y131	5.56	1	Yes	Yes	0	5	0	1
L:L:?33	R:R:D77	6.72	1	Yes	Yes	0	9	0	1
L:L:?33	R:R:W128	8.46	1	Yes	Yes	0	5	0	1
L:L:?33	R:R:S129	7.43	1	Yes	Yes	0	7	0	1
L:L:?33	R:R:Y131	8.7	1	Yes	Yes	0	5	0	1
R:R:P38	R:R:Y41	8.34	3	No	No	5	3	1	1
R:R:L40	R:R:P100	9.85	0	No	Yes	5	4	1	1
R:R:P100	R:R:Y41	8.34	0	Yes	No	4	3	1	1
R:R:M48	R:R:R45	6.2	0	No	No	6	7	2	2
R:R:F99	R:R:R45	9.62	1	Yes	No	5	7	1	2
R:R:M48	R:R:W79	4.65	0	No	Yes	6	6	2	1
R:R:D77	R:R:G78	5.03	1	Yes	No	9	5	1	1
R:R:D77	R:R:W82	8.93	1	Yes	Yes	9	9	1	2
R:R:D77	R:R:S129	8.83	1	Yes	Yes	9	7	1	1
R:R:D77	R:R:Y131	6.9	1	Yes	Yes	9	5	1	1
R:R:P96	R:R:W79	4.05	1	Yes	Yes	9	6	2	1
R:R:F99	R:R:W79	17.04	1	Yes	Yes	5	6	1	1
R:R:F102	R:R:W79	5.01	1	Yes	Yes	4	6	1	1
R:R:W79	R:R:Y131	19.29	1	Yes	Yes	6	5	1	1
R:R:V108	R:R:W82	3.68	0	No	Yes	7	9	2	2
R:R:K110	R:R:W82	20.89	1	Yes	Yes	8	9	2	2
R:R:F102	R:R:P96	5.78	1	Yes	Yes	4	9	1	2
R:R:P96	R:R:Y131	4.17	1	Yes	Yes	9	5	2	1
R:R:F102	R:R:F99	11.79	1	Yes	Yes	4	5	1	1
R:R:D101	R:R:P100	4.83	0	No	Yes	4	4	1	1
R:R:F102	R:R:Y131	3.09	1	Yes	Yes	4	5	1	1
R:R:C134	R:R:F102	5.59	0	No	Yes	9	4	2	1
R:R:F102	R:R:N135	4.83	1	Yes	No	4	3	1	1
R:R:D103	R:R:K141	5.53	0	Yes	No	3	3	2	1
R:R:V108	R:R:Y131	6.31	0	No	Yes	7	5	2	1
R:R:K110	R:R:S129	6.12	1	Yes	Yes	8	7	2	1
R:R:E123	R:R:H121	7.39	0	No	Yes	4	4	1	2
R:R:H121	R:R:W128	14.81	1	Yes	Yes	4	5	2	1
R:R:N130	R:R:W128	4.52	1	Yes	Yes	8	5	2	1
R:R:S129	R:R:Y131	7.63	1	Yes	Yes	7	5	1	1
R:R:Y146	R:R:Y150	4.96	0	No	No	2	4	1	2
R:R:Y149	R:R:Y150	8.94	0	Yes	No	5	4	1	2
R:R:I153	R:R:Y149	6.04	0	No	Yes	7	5	2	1
R:R:L202	R:R:Y149	8.21	0	No	Yes	7	5	2	1
R:R:H156	R:R:I198	9.28	0	No	Yes	7	7	2	1
R:R:H156	R:R:H381	13.14	0	No	No	7	9	2	2
R:R:I198	R:R:N194	7.08	0	Yes	No	7	8	1	2
R:R:N194	R:R:N233	8.17	0	No	Yes	8	9	2	2
R:R:P207	R:R:V206	3.53	0	No	No	3	3	2	1
R:R:G209	R:R:R213	4.5	0	No	No	3	2	1	2
R:R:C289	R:R:V212	8.54	3	No	No	9	3	2	1
R:R:L291	R:R:V212	2.98	3	No	No	6	3	1	1
R:R:H226	R:R:Q227	4.95	0	No	Yes	6	7	1	2
R:R:H226	R:R:M230	5.25	0	No	No	6	6	1	2
R:R:H302	R:R:Q227	4.95	2	Yes	Yes	6	7	1	2
R:R:M230	R:R:Y234	4.79	0	No	Yes	6	7	2	1
R:R:N233	R:R:Y234	3.49	2	Yes	Yes	9	7	2	1
R:R:M237	R:R:Y234	3.59	2	No	Yes	9	7	2	1
R:R:V305	R:R:Y234	7.57	2	No	Yes	7	7	1	1
R:R:F356	R:R:Y234	12.38	2	Yes	Yes	7	7	1	1
R:R:M237	R:R:Q383	5.44	2	No	Yes	9	9	2	2
R:R:H277	R:R:L298	5.14	0	No	Yes	7	6	2	1
R:R:C289	R:R:L291	3.17	3	No	No	9	6	2	1
R:R:L298	R:R:V293	2.98	2	Yes	No	6	6	1	1
R:R:H302	R:R:L298	6.43	2	Yes	Yes	6	6	1	1
R:R:F356	R:R:L309	3.65	2	Yes	No	7	7	1	2
R:R:G353	R:R:Q355	4.93	2	No	No	9	8	2	2
R:R:F356	R:R:G353	3.01	2	Yes	No	7	9	1	2
R:R:F356	R:R:Q355	9.37	2	Yes	No	7	8	1	2
R:R:Q355	R:R:Q383	8.96	2	No	Yes	8	9	2	2
R:R:F356	R:R:I380	8.79	2	Yes	No	7	6	1	2
R:R:F356	R:R:Q383	4.68	2	Yes	Yes	7	9	1	2
R:R:F359	R:R:Y372	5.16	10	Yes	Yes	6	7	2	2
R:R:F359	R:R:M376	6.22	10	Yes	Yes	6	7	2	1
R:R:M376	R:R:Y372	14.37	10	Yes	Yes	7	7	1	2
R:R:H377	R:R:H381	9.55	0	Yes	No	7	9	1	2
R:R:I198	R:R:L202	2.85	0	Yes	No	7	7	1	2
L:L:L19	R:R:K141	2.82	0	No	No	0	3	0	1
R:R:V203	R:R:Y149	2.52	0	No	Yes	3	5	2	1
L:L:L16	R:R:A145	1.58	0	Yes	No	0	4	0	1
R:R:M376	R:R:V375	1.52	10	Yes	No	7	4	1	2
R:R:K141	R:R:T138	1.5	0	No	No	3	2	1	2
R:R:H377	R:R:L151	1.29	0	Yes	No	7	5	1	2
L:L:R24	R:R:N135	1.21	0	No	No	0	3	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7TYW_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.98
Number of Linked Nodes	479
Number of Links	560
Number of Hubs	85
Number of Links mediated by Hubs	312
Number of Communities	14
Number of Nodes involved in Communities	98
Number of Links involved in Communities	137

Path Summary
Number Of Nodes in MetaPath	65
Number Of Links MetaPath	64
Number of Shortest Paths	459201
Length Of Smallest Path	3
Average Path Length	23.6065
Length of Longest Path	45
Minimum Path Strength	1.245
Average Path Strength	7.0178
Maximum Path Strength	28.895
Minimum Path Correlation	0.7
Average Path Correlation	0.968202
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	4.16667
Average % Of Corr. Nodes	50.2716
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	54.7888
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like • RAMP1-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like • RAMP1-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	NAG
PDB Residues	H:H:?1 H:H:?2
Environment Details	Open EMBL-EBI Page
Code	NAG
Name	N-Acetylglucosamine
Synonyms	N-Acetylchitosamine
Identifier
Formula	C8 H15 N O6
Molecular Weight	221.208
SMILES
PubChem	24139
Formal Charge	0
Total Atoms	30
Total Chiral Atoms	5
Total Bonds	30
Total Aromatic Bonds	0


Code	NH2
PDB Residues	L:L:?33
Environment Details	Open EMBL-EBI Page
Code	NH2
Name	AMINO GROUP
Synonyms
Identifier
Formula	H2 N
Molecular Weight	16.023
SMILES
PubChem	123329
Formal Charge	0
Total Atoms	3
Total Chiral Atoms	0
Total Bonds	2
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	E
Protein	RAMP1
UniProt	O60894
Sequence	>7TYW_nogp_Chain_E C Q E A N Y G A L L R E L C L T Q F Q V D M E A V G E T L W C D W G R T I R S Y R E L A D C T W H M A E K L G C F W P N A E V D R F F L A V H G R Y F R S C P I S I L Y P F I V V P I T V T L L V T A L V V W Q S K R T Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	L
Protein	Calcitonin-1
UniProt	B5XGR7
Sequence	>7TYW_nogp_Chain_L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	R
Protein	Receptor
UniProt	P30988
Sequence	>7TYW_nogp_Chain_R P F L Y V V G R K K M M D A Q Y K C Y D R M Q Q L P A Y Q G E G P Y C N R T W D G W L C W D D T P A G V L S Y Q F C P D Y F P D F D P S E K V T K Y C D E K G V W F K H P E N N R T W S N Y T M C N A F T P E K L K N A Y V L Y Y L A I V G H S L S I F T L V I S L G I F V F F R S L G C Q R V T L H K N M F L T Y I L N S M I I I I H L V E V V P N G E L V R R D P V S C K I L H F F H Q Y M M A C N Y F W M L C E G I Y L H T L I V V A V F T E K Q R L R W Y Y L L G W G F P L V P T T I H A I T R A V Y F N D N C W L S V E T H L L Y I I H G P V M A A L V V N F F F L L N I V R V L V T K M R E T H E A E S H M Y L K A V K A T M I L V P L L G I Q F V V F P W R P S N K M L G K I Y D Y V M H S L I H F Q G F F V A T I Y C F C N N E V Q T T V K R Q W A Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7TYF	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Amylin	-	Gs/β1/γ2; RAMP1	2.2	2022-03-23	doi.org/10.1126/science.abm9609
	7TYF (No Gprot)	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Amylin	-		2.2	2022-03-23	doi.org/10.1126/science.abm9609
	7TYW	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Calcitonin-1	-	Gs/β1/γ2; RAMP1	3	2022-03-23	doi.org/10.1126/science.abm9609
	7TYW (No Gprot)	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Calcitonin-1	-		3	2022-03-23	doi.org/10.1126/science.abm9609
	9AUC	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Calcitonin gene-related peptide-1	-	Gs/β1/γ2; RAMP1	2.4	2024-04-24	doi.org/10.1021/acs.biochem.4c00114
	9AUC (No Gprot)	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Calcitonin gene-related peptide-1	-		2.4	2024-04-24	doi.org/10.1021/acs.biochem.4c00114
	9BLW	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Cagrilintide (non-acylated)	-	Gs/β1/γ2; RAMP1	3.2	2025-04-16	doi.org/10.1038/s41467-025-58680-y
	9BLW (No Gprot)	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Cagrilintide (non-acylated)	-		3.2	2025-04-16	doi.org/10.1038/s41467-025-58680-y
	9BP3	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Cagrilintide	-	Gs/β1/γ2; RAMP1	2.2	2025-04-23	doi.org/10.1038/s41467-025-58680-y
	9BP3 (No Gprot)	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Cagrilintide	-		2.2	2025-04-23	doi.org/10.1038/s41467-025-58680-y

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