psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	E:E:C27	E:E:L80	3.17	No	No	0	9	5
2	E:E:C27	E:E:C82	7.28	No	No	0	9	9
3	E:E:N86	E:E:Q28	14.52	No	No	0	8	4
4	E:E:A87	E:E:Q28	4.55	No	No	0	4	4
5	E:E:T73	E:E:Y32	4.99	Yes	Yes	0	9	7
6	E:E:M76	E:E:Y32	13.17	No	Yes	0	6	7
7	E:E:C82	E:E:Y32	5.38	No	Yes	0	9	7
8	E:E:E38	E:E:L35	3.98	No	No	0	4	3
9	E:E:L36	E:E:M76	4.24	No	No	0	7	6
10	E:E:F92	E:E:L36	9.74	No	No	0	8	7
11	E:E:E38	E:E:R37	11.63	No	No	0	4	4
12	E:E:F92	E:E:R37	3.21	No	No	0	8	4
13	E:E:C40	E:E:L39	4.76	No	No	7	9	2
14	E:E:C72	E:E:L39	3.17	No	No	7	9	2
15	E:E:C40	E:E:C72	5.46	No	No	7	9	9
16	E:E:L41	E:E:V96	7.45	No	No	0	7	7
17	E:E:D47	E:E:F44	8.36	Yes	No	0	6	9
18	E:E:F44	E:E:L69	14.61	No	No	0	9	8
19	E:E:M48	E:E:Q45	4.08	Yes	No	8	9	4
20	E:E:E49	E:E:Q45	8.92	No	No	8	4	4
21	E:E:D47	E:E:V51	4.38	Yes	No	0	6	6
22	E:E:D47	E:E:S65	8.83	Yes	No	0	6	5
23	E:E:E49	E:E:M48	4.06	No	Yes	8	4	9
24	E:E:M48	E:E:Y100	23.95	Yes	No	0	9	9
25	E:E:E53	E:E:Y100	5.61	No	No	0	4	9
26	E:E:L55	E:E:T54	7.37	No	No	0	4	3
27	E:E:F101	E:E:W56	3.01	Yes	No	0	9	9
28	E:E:C104	E:E:C57	7.28	No	No	0	9	9
29	E:E:G60	E:E:W59	4.22	No	No	0	3	9
30	E:E:W59	R:R:Y53	6.75	No	Yes	0	9	1
31	E:E:G60	E:E:R61	4.5	No	No	0	3	5
32	E:E:S65	E:E:T62	3.2	No	No	0	5	9
33	E:E:E68	E:E:R64	6.98	No	No	0	4	3
34	E:E:F93	E:E:Y66	14.44	Yes	Yes	4	9	9
35	E:E:H97	E:E:Y66	13.07	Yes	Yes	4	9	9
36	E:E:Y66	R:R:M49	4.79	Yes	No	0	9	4
37	E:E:Y66	R:R:Q52	5.64	Yes	No	0	9	6
38	E:E:Y66	R:R:Y53	19.86	Yes	Yes	4	9	1
39	E:E:R67	R:R:M49	4.96	No	No	0	3	4
40	E:E:D71	E:E:H75	8.82	Yes	No	0	8	4
41	E:E:T73	E:E:W84	12.13	Yes	No	0	9	9
42	E:E:T73	E:E:V89	3.17	Yes	No	0	9	9
43	E:E:E78	E:E:W74	4.36	No	No	0	1	1
44	E:E:W74	E:E:W84	21.56	No	No	0	1	9
45	E:E:F83	R:R:N124	6.04	No	No	1	5	5
46	E:E:F83	R:R:R126	7.48	No	Yes	1	5	4
47	E:E:P85	E:E:W84	17.57	No	No	0	9	9
48	E:E:P85	R:R:W76	6.76	No	No	0	9	8
49	E:E:P85	R:R:G78	4.06	No	No	0	9	5
50	E:E:N86	R:R:R126	6.03	No	Yes	0	8	4
51	E:E:E88	E:E:R91	6.98	No	No	0	4	3
52	E:E:E88	E:E:F92	4.66	No	No	0	4	8
53	E:E:A95	E:E:R91	4.15	No	No	0	4	3
54	E:E:F93	E:E:V96	3.93	Yes	No	4	9	7
55	E:E:F93	E:E:H97	16.97	Yes	Yes	4	9	9
56	E:E:F93	R:R:Y56	20.63	Yes	Yes	4	9	3
57	E:E:L94	R:R:Y56	8.21	No	Yes	0	5	3
58	E:E:L94	R:R:M59	7.07	No	No	0	5	5
59	E:E:H97	E:E:V96	6.92	Yes	No	4	9	7
60	E:E:F101	E:E:H97	13.58	Yes	Yes	4	9	9
61	E:E:H97	R:R:Y53	11.98	Yes	Yes	4	9	1
62	E:E:H97	R:R:Y56	10.89	Yes	Yes	4	9	3
63	E:E:F101	E:E:Y100	14.44	Yes	No	0	9	9
64	E:E:F101	R:R:Y53	9.28	Yes	Yes	4	9	1
65	E:E:C104	E:E:P105	3.77	No	No	0	9	6
66	E:E:I106	R:R:K54	11.63	No	No	0	4	4
67	E:E:I123	E:E:L119	7.14	No	No	0	9	9
68	E:E:L119	E:E:V124	2.98	No	No	0	9	4
69	E:E:V125	E:E:Y120	3.79	No	No	0	6	6
70	E:E:F122	E:E:P121	5.78	No	No	0	8	8
71	E:E:I123	R:R:Y299	6.04	No	No	0	9	7
72	E:E:P126	E:E:V125	3.53	No	No	0	9	6
73	E:E:P126	R:R:P304	3.9	No	Yes	0	9	9
74	E:E:I127	R:R:A307	4.87	No	No	0	6	3
75	E:E:T130	R:R:F269	7.78	No	Yes	0	9	3
76	E:E:T130	R:R:P304	6.99	No	Yes	0	9	9
77	E:E:V133	R:R:F269	10.49	No	Yes	0	7	3
78	E:E:T134	R:R:L238	7.37	No	Yes	0	9	8
79	E:E:V137	R:R:I242	4.61	No	Yes	0	9	7
80	E:E:V137	R:R:L265	8.94	No	Yes	0	9	7
81	E:E:V138	R:R:I242	7.68	No	Yes	0	9	7
82	E:E:Q140	E:E:W139	7.67	No	No	5	8	9
83	E:E:K142	E:E:W139	3.48	No	No	0	8	9
84	E:E:R143	E:E:W139	5	No	No	5	6	9
85	E:E:Q140	E:E:R143	5.84	No	No	5	8	6
86	E:E:Q140	R:R:W261	24.09	No	Yes	5	8	2
87	E:E:S141	R:R:T246	9.59	No	Yes	0	9	7
88	E:E:K142	R:R:V250	3.04	No	No	0	8	5
89	H:H:?1	R:R:H121	4.61	Yes	Yes	1	0	4
90	H:H:?1	R:R:W128	7.15	Yes	Yes	1	0	5
91	H:H:?1	R:R:N130	24.64	Yes	Yes	1	0	8
92	H:H:?1	R:R:T132	3.97	Yes	No	1	0	6
93	H:H:?1	R:R:M133	10.15	Yes	Yes	1	0	5
94	H:H:?2	R:R:Y65	4.21	No	Yes	9	0	3
95	H:H:?2	R:R:Y71	6.31	No	No	9	0	3
96	H:H:?2	R:R:N73	34.5	No	No	0	0	4
97	L:L:C1	L:L:L4	3.17	Yes	No	0	0	0
98	L:L:C1	L:L:C7	7.28	Yes	No	2	0	0
99	L:L:C1	R:R:L298	3.17	Yes	Yes	2	0	6
100	L:L:C1	R:R:H302	11.79	Yes	Yes	2	0	6
101	L:L:N3	L:L:S2	4.47	No	Yes	0	0	0
102	L:L:K11	L:L:S2	6.12	No	Yes	0	0	0
103	L:L:S2	R:R:V293	3.23	Yes	No	0	0	6
104	L:L:S2	R:R:E294	8.62	Yes	No	0	0	3
105	L:L:N3	R:R:W361	14.69	No	No	0	0	4
106	L:L:L4	L:L:T6	4.42	No	Yes	0	0	0
107	L:L:L4	R:R:M306	5.65	No	No	0	0	4
108	L:L:S5	R:R:F356	7.93	No	Yes	0	0	7
109	L:L:S5	R:R:M376	3.07	No	Yes	0	0	7
110	L:L:T6	R:R:Y234	3.75	Yes	Yes	2	0	7
111	L:L:T6	R:R:H302	8.21	Yes	Yes	2	0	6
112	L:L:T6	R:R:V305	3.17	Yes	No	2	0	7
113	L:L:C7	R:R:H302	7.37	No	Yes	2	0	6
114	L:L:V8	R:R:H377	5.54	No	Yes	0	0	7
115	L:L:L9	R:R:I198	7.14	No	Yes	0	0	7
116	L:L:L9	R:R:H226	3.86	No	No	0	0	6
117	L:L:K11	L:L:Q14	5.42	No	Yes	0	0	0
118	L:L:E15	L:L:K11	9.45	No	No	0	0	0
119	L:L:L12	R:R:H377	7.71	No	Yes	0	0	7
120	L:L:S13	R:R:V206	3.23	No	No	0	0	3
121	L:L:K18	L:L:Q14	4.07	Yes	Yes	0	0	0
122	L:L:Q14	R:R:V293	5.73	Yes	No	0	0	6
123	L:L:Q14	R:R:E294	10.19	Yes	No	0	0	3
124	L:L:E15	L:L:K18	6.75	No	Yes	0	0	0
125	L:L:L16	R:R:Y146	9.38	Yes	No	0	0	2
126	L:L:L16	R:R:Y149	5.86	Yes	Yes	0	0	5
127	L:L:L16	R:R:V206	4.47	Yes	No	0	0	3
128	L:L:H17	L:L:T21	12.32	Yes	No	3	0	0
129	L:L:H17	L:L:Y22	6.53	Yes	Yes	3	0	0
130	L:L:H17	R:R:V212	11.07	Yes	No	3	0	3
131	L:L:H17	R:R:L291	7.71	Yes	No	3	0	6
132	L:L:K18	L:L:Y22	3.58	Yes	Yes	0	0	0
133	L:L:K18	R:R:P100	5.02	Yes	Yes	0	0	4
134	L:L:Q20	R:R:L142	10.65	No	No	0	0	2
135	L:L:Q20	R:R:Y146	10.15	No	No	0	0	2
136	L:L:T21	L:L:Y22	4.99	No	Yes	3	0	0
137	L:L:T21	R:R:G209	3.64	No	No	0	0	3
138	L:L:P23	L:L:Y22	4.17	No	Yes	0	0	0
139	L:L:Y22	R:R:P38	4.17	Yes	No	3	0	5
140	L:L:Y22	R:R:L40	3.52	Yes	No	0	0	5
141	L:L:Y22	R:R:Y41	8.94	Yes	No	3	0	3
142	L:L:T25	L:L:T27	3.14	Yes	No	0	0	0
143	L:L:T25	R:R:F99	7.78	Yes	Yes	1	0	5
144	L:L:T25	R:R:D101	5.78	Yes	No	0	0	4
145	L:L:T25	R:R:F102	6.49	Yes	Yes	1	0	4
146	L:L:T27	R:R:N135	8.77	No	No	0	0	3
147	L:L:S29	R:R:E123	14.37	No	No	0	0	4
148	L:L:?33	L:L:P32	12.19	Yes	Yes	1	0	0
149	L:L:P32	R:R:D77	8.05	Yes	Yes	1	0	9
150	L:L:P32	R:R:G78	4.06	Yes	No	1	0	5
151	L:L:P32	R:R:W79	20.27	Yes	Yes	1	0	6
152	L:L:P32	R:R:Y131	5.56	Yes	Yes	1	0	5
153	L:L:?33	R:R:D77	6.72	Yes	Yes	1	0	9
154	L:L:?33	R:R:W128	8.46	Yes	Yes	1	0	5
155	L:L:?33	R:R:S129	7.43	Yes	Yes	1	0	7
156	L:L:?33	R:R:Y131	8.7	Yes	Yes	1	0	5
157	R:R:P38	R:R:Y41	8.34	No	No	3	5	3
158	R:R:F39	R:R:V43	5.24	No	No	0	4	2
159	R:R:D287	R:R:F39	7.17	Yes	No	0	3	4
160	R:R:L40	R:R:P100	9.85	No	Yes	0	5	4
161	R:R:P100	R:R:Y41	8.34	Yes	No	0	4	3
162	R:R:K46	R:R:V42	3.04	No	No	0	4	1
163	R:R:K46	R:R:V43	9.11	No	No	0	4	2
164	R:R:M48	R:R:R45	6.2	No	No	0	6	7
165	R:R:F99	R:R:R45	9.62	Yes	No	0	5	7
166	R:R:M48	R:R:W79	4.65	No	Yes	0	6	6
167	R:R:M48	R:R:Y98	19.16	No	Yes	0	6	4
168	R:R:Q52	R:R:W76	16.43	No	No	0	6	8
169	R:R:D57	R:R:K54	4.15	No	No	0	4	4
170	R:R:C55	R:R:C81	7.28	No	No	0	9	9
171	R:R:Q60	R:R:Y56	19.16	Yes	Yes	0	3	3
172	R:R:D57	R:R:Q60	3.92	No	Yes	0	4	3
173	R:R:D57	R:R:Q61	13.05	No	No	0	4	3
174	R:R:D83	R:R:R58	7.15	No	No	0	5	3
175	R:R:M59	R:R:R74	11.17	No	No	0	5	4
176	R:R:L62	R:R:P63	6.57	No	No	0	3	1
177	R:R:L62	R:R:R74	3.64	No	No	0	3	4
178	R:R:D84	R:R:L62	4.07	No	No	0	4	3
179	R:R:Q66	R:R:Y65	3.38	No	Yes	0	1	3
180	R:R:G67	R:R:Y65	5.79	No	Yes	0	2	3
181	R:R:Y65	R:R:Y71	41.7	Yes	No	9	3	3
182	R:R:D84	R:R:Y65	16.09	No	Yes	0	4	3
183	R:R:P86	R:R:Y65	5.56	No	Yes	0	2	3
184	R:R:E68	R:R:G69	4.91	No	No	0	1	1
185	R:R:G69	R:R:P70	4.06	No	No	0	1	1
186	R:R:C112	R:R:C72	7.28	No	No	1	9	9
187	R:R:C72	R:R:W118	16.98	No	Yes	1	9	9
188	R:R:D83	R:R:R74	11.91	No	No	0	5	4
189	R:R:K110	R:R:T75	4.5	Yes	No	1	8	5
190	R:R:T75	R:R:W118	12.13	No	Yes	1	5	9
191	R:R:C81	R:R:W76	5.22	No	No	0	9	8
192	R:R:D77	R:R:G78	5.03	Yes	No	1	9	5
193	R:R:D77	R:R:W82	8.93	Yes	Yes	0	9	9
194	R:R:D77	R:R:S129	8.83	Yes	Yes	1	9	7
195	R:R:D77	R:R:Y131	6.9	Yes	Yes	1	9	5
196	R:R:P96	R:R:W79	4.05	Yes	Yes	1	9	6
197	R:R:F99	R:R:W79	17.04	Yes	Yes	1	5	6
198	R:R:F102	R:R:W79	5.01	Yes	Yes	1	4	6
199	R:R:W79	R:R:Y131	19.29	Yes	Yes	1	6	5
200	R:R:L80	R:R:P96	8.21	No	Yes	1	5	9
201	R:R:L80	R:R:Y98	4.69	No	Yes	1	5	4
202	R:R:Q93	R:R:W82	5.48	No	Yes	0	6	9
203	R:R:V108	R:R:W82	3.68	No	Yes	0	7	9
204	R:R:K110	R:R:W82	20.89	Yes	Yes	0	8	9
205	R:R:P86	R:R:T85	5.25	No	No	0	2	7
206	R:R:S91	R:R:T85	9.59	No	No	0	5	7
207	R:R:L90	R:R:T109	5.9	No	No	0	4	5
208	R:R:L90	R:R:Y111	9.38	No	Yes	0	4	4
209	R:R:K107	R:R:Y92	11.94	No	No	0	3	4
210	R:R:T109	R:R:Y92	6.24	No	No	0	5	4
211	R:R:C134	R:R:C95	7.28	No	No	0	9	9
212	R:R:P96	R:R:Y98	6.95	Yes	Yes	1	9	4
213	R:R:F102	R:R:P96	5.78	Yes	Yes	1	4	9
214	R:R:P96	R:R:Y131	4.17	Yes	Yes	1	9	5
215	R:R:F102	R:R:F99	11.79	Yes	Yes	1	4	5
216	R:R:D101	R:R:P100	4.83	No	Yes	0	4	4
217	R:R:F102	R:R:Y131	3.09	Yes	Yes	1	4	5
218	R:R:C134	R:R:F102	5.59	No	Yes	0	9	4
219	R:R:F102	R:R:N135	4.83	Yes	No	0	4	3
220	R:R:D103	R:R:S105	4.42	Yes	No	0	3	1
221	R:R:D103	R:R:E106	3.9	Yes	No	0	3	4
222	R:R:D103	R:R:K141	5.53	Yes	No	0	3	3
223	R:R:E106	R:R:M133	8.12	No	Yes	0	4	5
224	R:R:K107	R:R:M133	11.52	No	Yes	0	3	5
225	R:R:V108	R:R:Y131	6.31	No	Yes	0	7	5
226	R:R:N130	R:R:T109	5.85	Yes	No	0	8	5
227	R:R:K110	R:R:W118	18.57	Yes	Yes	1	8	9
228	R:R:K110	R:R:T127	7.51	Yes	No	1	8	4
229	R:R:K110	R:R:S129	6.12	Yes	Yes	1	8	7
230	R:R:D113	R:R:Y111	12.64	No	Yes	0	5	4
231	R:R:F119	R:R:Y111	10.32	No	Yes	0	4	4
232	R:R:C112	R:R:W118	7.84	No	Yes	1	9	9
233	R:R:D113	R:R:E114	15.59	No	No	0	5	2
234	R:R:K115	R:R:V117	3.04	No	No	0	5	5
235	R:R:T127	R:R:W118	3.64	No	Yes	1	4	9
236	R:R:K120	R:R:N125	9.79	No	No	0	1	7
237	R:R:H121	R:R:P122	9.15	Yes	No	0	4	5
238	R:R:E123	R:R:H121	7.39	No	Yes	0	4	4
239	R:R:H121	R:R:W128	14.81	Yes	Yes	1	4	5
240	R:R:N124	R:R:R126	4.82	No	Yes	1	5	4
241	R:R:R126	R:R:T127	10.35	Yes	No	1	4	4
242	R:R:N130	R:R:W128	4.52	Yes	Yes	1	8	5
243	R:R:S129	R:R:Y131	7.63	Yes	Yes	1	7	5
244	R:R:N130	R:R:T132	7.31	Yes	No	1	8	6
245	R:R:M133	R:R:N130	4.21	Yes	Yes	1	5	8
246	R:R:P139	R:R:T138	5.25	No	No	0	3	2
247	R:R:Y146	R:R:Y150	4.96	No	No	0	2	4
248	R:R:V147	R:R:Y374	6.31	No	No	0	4	6
249	R:R:D373	R:R:L148	5.43	No	No	0	5	5
250	R:R:L148	R:R:Y374	9.38	No	No	0	5	6
251	R:R:Y149	R:R:Y150	8.94	Yes	No	0	5	4
252	R:R:I153	R:R:Y149	6.04	No	Yes	0	7	5
253	R:R:L202	R:R:Y149	8.21	No	Yes	0	7	5
254	R:R:L151	R:R:S378	3	No	No	0	5	5
255	R:R:A152	R:R:H381	7.32	No	No	0	7	9
256	R:R:F382	R:R:G155	9.03	No	No	0	7	8
257	R:R:H156	R:R:S195	8.37	No	Yes	0	7	7
258	R:R:H156	R:R:I198	9.28	No	Yes	0	7	7
259	R:R:H156	R:R:H381	13.14	No	No	0	7	9
260	R:R:S159	R:R:S195	3.26	No	Yes	0	9	7
261	R:R:G384	R:R:S159	3.71	No	No	0	9	9
262	R:R:I160	R:R:I192	4.42	No	Yes	0	5	7
263	R:R:I160	R:R:S195	7.74	No	Yes	0	5	7
264	R:R:F385	R:R:T162	9.08	Yes	No	0	5	6
265	R:R:A388	R:R:T162	3.36	No	No	0	8	6
266	R:R:F188	R:R:L163	6.09	No	No	0	8	8
267	R:R:I192	R:R:L163	5.71	Yes	No	0	7	8
268	R:R:A388	R:R:L163	3.15	No	No	0	8	8
269	R:R:F393	R:R:I165	3.77	No	No	0	8	5
270	R:R:A388	R:R:S166	3.42	No	No	0	8	9
271	R:R:C392	R:R:S166	6.89	No	No	0	9	9
272	R:R:F393	R:R:S166	3.96	No	No	0	8	9
273	R:R:F173	R:R:I169	3.77	Yes	No	0	7	8
274	R:R:C392	R:R:I169	3.27	No	No	0	9	8
275	R:R:F170	R:R:V181	11.8	Yes	No	0	8	9
276	R:R:F170	R:R:H184	3.39	Yes	No	0	8	9
277	R:R:F170	R:R:K185	4.96	Yes	No	0	8	6
278	R:R:F170	R:R:F188	6.43	Yes	No	0	8	8
279	R:R:C392	R:R:F170	6.98	No	Yes	0	9	8
280	R:R:F172	R:R:F173	5.36	No	Yes	0	2	7
281	R:R:F173	R:R:T401	3.89	Yes	No	0	7	7
282	R:R:F173	R:R:V402	3.93	Yes	No	0	7	5
283	R:R:F173	R:R:Q405	5.86	Yes	No	0	7	4
284	R:R:L176	R:R:V398	4.47	No	No	0	9	9
285	R:R:Q179	R:R:Y243	7.89	No	Yes	0	7	8
286	R:R:K256	R:R:Q179	8.14	No	No	0	5	7
287	R:R:L259	R:R:Q179	6.65	Yes	No	0	5	7
288	R:R:R180	R:R:V181	3.92	No	No	0	9	9
289	R:R:H184	R:R:R180	6.77	No	No	0	9	9
290	R:R:L183	R:R:W236	3.42	Yes	Yes	0	8	9
291	R:R:E240	R:R:L183	3.98	Yes	Yes	0	9	8
292	R:R:L183	R:R:Y243	5.86	Yes	Yes	0	8	8
293	R:R:L183	R:R:L259	4.15	Yes	Yes	0	8	5
294	R:R:E240	R:R:H184	8.62	Yes	No	0	9	9
295	R:R:N186	R:R:W236	11.3	No	Yes	2	9	9
296	R:R:N186	R:R:Y263	5.81	No	No	2	9	5
297	R:R:M187	R:R:Y191	5.99	No	Yes	0	8	8
298	R:R:E240	R:R:M187	10.83	Yes	No	0	9	8
299	R:R:F188	R:R:V387	3.93	No	No	0	8	9
300	R:R:L189	R:R:L193	5.54	No	No	0	3	6
301	R:R:L189	R:R:W267	4.56	No	Yes	0	3	9
302	R:R:T190	R:R:Y191	3.75	No	Yes	2	9	8
303	R:R:N233	R:R:T190	8.77	Yes	No	2	9	9
304	R:R:T190	R:R:W236	4.85	No	Yes	2	9	9
305	R:R:N233	R:R:Y191	13.96	Yes	Yes	2	9	8
306	R:R:M237	R:R:Y191	5.99	No	Yes	2	9	8
307	R:R:Q383	R:R:Y191	13.53	Yes	Yes	2	9	8
308	R:R:G384	R:R:Y191	5.79	No	Yes	0	9	8
309	R:R:V387	R:R:Y191	6.31	No	Yes	0	9	8
310	R:R:L193	R:R:M229	7.07	No	No	0	6	4
311	R:R:I198	R:R:N194	7.08	Yes	No	0	7	8
312	R:R:N194	R:R:N233	8.17	No	Yes	0	8	9
313	R:R:H201	R:R:V205	9.69	No	No	0	6	7
314	R:R:L211	R:R:V205	2.98	Yes	No	0	1	7
315	R:R:P207	R:R:V206	3.53	No	No	0	3	3
316	R:R:E210	R:R:N208	10.52	No	No	0	3	3
317	R:R:L211	R:R:N208	8.24	Yes	No	0	1	3
318	R:R:G209	R:R:R213	4.5	No	No	0	3	2
319	R:R:L211	R:R:P216	6.57	Yes	No	3	1	4
320	R:R:C219	R:R:L211	3.17	No	Yes	3	9	1
321	R:R:C289	R:R:V212	8.54	No	No	3	9	3
322	R:R:L291	R:R:V212	2.98	No	No	3	6	3
323	R:R:P216	R:R:R214	10.09	No	No	0	4	4
324	R:R:D215	R:R:K220	8.3	No	No	0	6	7
325	R:R:D215	R:R:N288	14.81	No	No	0	6	4
326	R:R:C219	R:R:P216	5.65	No	No	3	9	4
327	R:R:C219	R:R:C289	7.28	No	No	3	9	9
328	R:R:K220	R:R:N286	9.79	No	No	13	7	7
329	R:R:K220	R:R:W290	20.89	No	Yes	13	7	9
330	R:R:H223	R:R:Q227	11.13	No	Yes	0	5	7
331	R:R:H223	R:R:W290	10.58	No	Yes	0	5	9
332	R:R:F224	R:R:F225	3.22	No	No	0	5	5
333	R:R:F224	R:R:T274	5.19	No	No	0	5	6
334	R:R:H226	R:R:Q227	4.95	No	Yes	0	6	7
335	R:R:H226	R:R:M230	5.25	No	No	0	6	6
336	R:R:I301	R:R:Q227	6.86	No	Yes	0	7	7
337	R:R:H302	R:R:Q227	4.95	Yes	Yes	0	6	7
338	R:R:C232	R:R:Y228	9.41	No	No	0	8	8
339	R:R:L271	R:R:Y228	5.86	No	No	0	4	8
340	R:R:M229	R:R:W267	4.65	No	Yes	0	4	9
341	R:R:M230	R:R:Y234	4.79	No	Yes	0	6	7
342	R:R:C232	R:R:W267	3.92	No	Yes	0	8	9
343	R:R:C232	R:R:P270	7.53	No	Yes	0	8	9
344	R:R:N233	R:R:Y234	3.49	Yes	Yes	2	9	7
345	R:R:M237	R:R:Y234	3.59	No	Yes	2	9	7
346	R:R:V305	R:R:Y234	7.57	No	Yes	2	7	7
347	R:R:F356	R:R:Y234	12.38	Yes	Yes	2	7	7
348	R:R:F235	R:R:L265	3.65	Yes	Yes	6	5	7
349	R:R:F235	R:R:F269	8.57	Yes	Yes	6	5	3
350	R:R:F235	R:R:P270	5.78	Yes	Yes	6	5	9
351	R:R:A308	R:R:F235	4.16	No	Yes	0	7	5
352	R:R:C239	R:R:W236	6.53	No	Yes	0	7	9
353	R:R:W236	R:R:Y263	3.86	Yes	No	2	9	5
354	R:R:G266	R:R:W236	8.44	No	Yes	0	9	9
355	R:R:W236	R:R:W267	14.99	Yes	Yes	0	9	9
356	R:R:M237	R:R:Q383	5.44	No	Yes	2	9	9
357	R:R:I242	R:R:L238	7.14	Yes	Yes	0	7	8
358	R:R:A308	R:R:L238	3.15	No	Yes	0	7	8
359	R:R:L238	R:R:V311	2.98	Yes	No	0	8	6
360	R:R:L238	R:R:N312	8.24	Yes	No	0	8	9
361	R:R:C239	R:R:L265	4.76	No	Yes	0	7	7
362	R:R:E240	R:R:L351	9.28	Yes	No	0	9	9
363	R:R:I242	R:R:Y262	4.84	Yes	Yes	0	7	7
364	R:R:F315	R:R:I242	3.77	No	Yes	0	8	7
365	R:R:L247	R:R:Y243	8.21	No	Yes	0	8	8
366	R:R:Q257	R:R:Y243	7.89	No	Yes	12	5	8
367	R:R:Y243	R:R:Y262	4.96	Yes	Yes	12	8	7
368	R:R:I319	R:R:L244	7.14	No	No	0	9	9
369	R:R:H245	R:R:V249	9.69	Yes	No	0	8	6
370	R:R:H245	R:R:V250	4.15	Yes	No	0	8	5
371	R:R:F315	R:R:H245	26.02	No	Yes	0	8	8
372	R:R:H245	R:R:N318	7.65	Yes	No	0	8	8
373	R:R:T246	R:R:V250	6.35	Yes	No	0	7	5
374	R:R:Q257	R:R:T246	7.09	No	Yes	0	5	7
375	R:R:I248	R:R:L247	4.28	Yes	No	0	7	8
376	R:R:I248	R:R:V249	3.07	Yes	No	0	7	6
377	R:R:I248	R:R:V322	4.61	Yes	No	0	7	8
378	R:R:A251	R:R:T254	5.03	No	No	0	6	6
379	R:R:Q257	R:R:Y262	4.51	No	Yes	12	5	7
380	R:R:R258	R:R:R260	5.33	No	No	5	5	3
381	R:R:R258	R:R:W261	3	No	Yes	5	5	2
382	R:R:L259	R:R:Y262	4.69	Yes	Yes	0	5	7
383	R:R:L259	R:R:Y263	4.69	Yes	No	0	5	5
384	R:R:R260	R:R:W261	6	No	Yes	5	3	2
385	R:R:F269	R:R:L265	3.65	Yes	Yes	6	3	7
386	R:R:F269	R:R:P270	4.33	Yes	Yes	6	3	9
387	R:R:P273	R:R:V272	3.53	No	No	0	6	4
388	R:R:I276	R:R:I300	4.42	No	No	0	5	8
389	R:R:H277	R:R:R281	10.16	No	Yes	0	7	7
390	R:R:H277	R:R:L298	5.14	No	Yes	0	7	6
391	R:R:H277	R:R:I301	13.26	No	No	0	7	7
392	R:R:T280	R:R:Y284	3.75	No	No	0	4	2
393	R:R:L297	R:R:T280	4.42	No	No	0	4	4
394	R:R:D287	R:R:R281	5.96	Yes	Yes	0	3	7
395	R:R:R281	R:R:W290	17.99	Yes	Yes	0	7	9
396	R:R:R281	R:R:T295	5.17	Yes	No	0	7	4
397	R:R:V283	R:R:Y284	6.31	No	No	0	3	2
398	R:R:D287	R:R:F285	10.75	Yes	No	0	3	6
399	R:R:F285	R:R:T295	9.08	No	No	0	6	4
400	R:R:N286	R:R:W290	6.78	No	Yes	13	7	9
401	R:R:D287	R:R:S292	4.42	Yes	No	0	3	4
402	R:R:C289	R:R:L291	3.17	No	No	3	9	6
403	R:R:L298	R:R:V293	2.98	Yes	No	0	6	6
404	R:R:L297	R:R:T295	5.9	No	No	0	4	4
405	R:R:H296	R:R:Y299	6.53	No	No	0	2	7
406	R:R:H302	R:R:L298	6.43	Yes	Yes	2	6	6
407	R:R:F356	R:R:L309	3.65	Yes	No	0	7	7
408	R:R:F315	R:R:V311	7.87	No	No	0	8	6
409	R:R:L352	R:R:N312	4.12	No	No	0	9	9
410	R:R:F313	R:R:L317	3.65	No	No	0	6	5
411	R:R:F313	R:R:V357	9.18	No	No	0	6	7
412	R:R:L316	R:R:V320	2.98	No	No	0	9	7
413	R:R:L316	R:R:L348	4.15	No	No	0	9	9
414	R:R:I354	R:R:L316	5.71	No	No	0	6	9
415	R:R:N318	R:R:R321	4.82	No	No	0	8	8
416	R:R:T345	R:R:V320	4.76	No	No	0	9	7
417	R:R:K326	R:R:V322	3.04	No	No	0	9	8
418	R:R:E329	R:R:K326	5.4	No	No	0	6	9
419	R:R:E332	R:R:M327	4.06	No	No	0	5	7
420	R:R:M327	R:R:M337	5.78	No	No	0	7	7
421	R:R:K340	R:R:M327	5.76	No	No	0	8	7
422	R:R:E334	R:R:R328	3.49	No	No	14	6	6
423	R:R:M337	R:R:R328	6.2	No	No	14	7	6
424	R:R:E332	R:R:T330	7.06	No	No	0	5	5
425	R:R:E332	R:R:H336	6.15	No	No	0	5	6
426	R:R:E334	R:R:M337	8.12	No	No	14	6	7
427	R:R:E334	R:R:Y338	4.49	No	No	0	6	7
428	R:R:H336	R:R:K340	10.48	No	No	0	6	8
429	R:R:M346	R:R:T345	3.01	No	No	0	8	9
430	R:R:I347	R:R:I390	5.89	No	No	0	8	8
431	R:R:L348	R:R:Y391	4.69	No	No	0	9	8
432	R:R:P350	R:R:V349	5.3	No	No	0	9	8
433	R:R:I354	R:R:V349	7.68	No	No	0	6	8
434	R:R:L351	R:R:Y391	11.72	No	No	0	9	8
435	R:R:G353	R:R:Q355	4.93	No	No	2	9	8
436	R:R:F356	R:R:G353	3.01	Yes	No	2	7	9
437	R:R:F356	R:R:Q355	9.37	Yes	No	2	7	8
438	R:R:Q355	R:R:Q383	8.96	No	Yes	2	8	9
439	R:R:F356	R:R:I380	8.79	Yes	No	0	7	6
440	R:R:F356	R:R:Q383	4.68	Yes	Yes	2	7	9
441	R:R:F359	R:R:V358	6.55	Yes	No	0	6	5
442	R:R:F359	R:R:Y372	5.16	Yes	Yes	10	6	7
443	R:R:F359	R:R:M376	6.22	Yes	Yes	10	6	7
444	R:R:G369	R:R:R362	6	No	No	0	4	4
445	R:R:R362	R:R:Y372	7.2	No	Yes	0	4	7
446	R:R:D373	R:R:R362	14.29	No	No	0	5	4
447	R:R:L368	R:R:P363	3.28	No	No	0	3	7
448	R:R:P363	R:R:Y372	8.34	No	Yes	0	7	7
449	R:R:L368	R:R:N365	12.36	No	No	0	3	4
450	R:R:M376	R:R:Y372	14.37	Yes	Yes	10	7	7
451	R:R:L379	R:R:V375	2.98	No	No	0	5	4
452	R:R:H377	R:R:H381	9.55	Yes	No	0	7	9
453	R:R:F382	R:R:F385	5.36	No	Yes	11	7	5
454	R:R:F382	R:R:F386	3.22	No	No	11	7	5
455	R:R:F385	R:R:F386	4.29	Yes	No	11	5	5
456	R:R:F385	R:R:T389	7.78	Yes	No	0	5	5
457	R:R:F393	R:R:T389	5.19	No	No	0	8	5
458	R:R:I390	R:R:Y391	7.25	No	No	0	8	8
459	R:R:E397	R:R:N395	10.52	No	No	0	9	9
460	R:R:N395	R:R:V398	8.87	No	No	0	9	9
461	R:R:N396	R:R:Q399	6.6	No	No	0	6	7
462	R:R:R404	R:R:T400	3.88	No	No	0	7	4
463	R:R:I248	R:R:I319	2.94	Yes	No	0	7	9
464	L:L:N26	L:L:T31	2.92	No	No	0	0	0
465	R:R:I192	R:R:M196	2.92	Yes	No	0	7	4
466	E:E:G33	E:E:Y32	2.9	No	Yes	0	4	7
467	E:E:I127	E:E:L131	2.85	No	No	0	6	9
468	R:R:I192	R:R:L167	2.85	Yes	No	0	7	6
469	R:R:I198	R:R:L202	2.85	Yes	No	0	7	7
470	R:R:E204	R:R:V205	2.85	No	No	0	4	7
471	L:L:L19	R:R:K141	2.82	No	No	0	0	3
472	R:R:K143	R:R:N144	2.8	No	No	0	1	4
473	E:E:P121	E:E:Y120	2.78	No	No	0	8	6
474	E:E:D90	R:R:M59	2.77	No	No	0	9	5
475	R:R:A278	R:R:F224	2.77	No	No	0	6	5
476	E:E:R102	E:E:S103	2.64	No	No	0	4	5
477	E:E:E29	E:E:N31	2.63	No	No	0	4	1
478	R:R:F161	R:R:T162	2.59	No	No	0	4	6
479	R:R:A282	R:R:W290	2.59	No	Yes	0	3	9
480	R:R:H201	R:R:L222	2.57	No	No	0	6	6
481	E:E:V124	E:E:Y120	2.52	No	No	0	4	6
482	R:R:V203	R:R:Y149	2.52	No	Yes	0	3	5
483	R:R:F225	R:R:I221	2.51	No	No	0	5	4
484	R:R:F313	R:R:I354	2.51	No	No	0	6	6
485	R:R:T274	R:R:Y228	2.5	No	No	0	6	8
486	R:R:F170	R:R:L176	2.44	Yes	No	0	8	9
487	R:R:F314	R:R:L317	2.44	No	No	0	5	5
488	R:R:K47	R:R:Y98	2.39	No	Yes	0	4	4
489	E:E:D58	E:E:R61	2.38	No	No	0	7	5
490	E:E:R102	R:R:Q60	2.34	No	Yes	0	4	3
491	R:R:L264	R:R:W261	2.28	No	Yes	0	3	2
492	R:R:G116	R:R:P70	2.03	No	No	0	9	1
493	R:R:G268	R:R:P270	2.03	No	Yes	0	6	9
494	R:R:G303	R:R:P304	2.03	No	Yes	0	4	9
495	R:R:C178	R:R:G177	1.96	No	No	0	8	7
496	R:R:A87	R:R:G88	1.95	No	No	0	4	8
497	R:R:P273	R:R:P304	1.95	No	Yes	0	6	9
498	R:R:A231	R:R:P270	1.87	No	Yes	0	5	9
499	L:L:G10	L:L:S13	1.86	No	No	0	0	0
500	E:E:G52	E:E:V51	1.84	No	No	0	6	6
501	R:R:G44	R:R:V43	1.84	No	No	0	4	2
502	R:R:G88	R:R:V89	1.84	No	No	0	8	5
503	R:R:G168	R:R:V171	1.84	No	No	0	1	4
504	L:L:G28	L:L:T31	1.82	No	No	0	0	0
505	E:E:A77	E:E:C82	1.81	No	No	0	9	9
506	E:E:I127	R:R:G303	1.76	No	No	0	6	4
507	L:L:P32	L:L:T31	1.75	Yes	No	0	0	0
508	R:R:G241	R:R:L244	1.71	No	No	0	8	9
509	R:R:G241	R:R:L352	1.71	No	No	0	8	9
510	R:R:A341	R:R:V320	1.7	No	No	0	9	7
511	R:R:A341	R:R:V324	1.7	No	No	0	9	5
512	E:E:A70	E:E:T73	1.68	No	Yes	0	8	9
513	R:R:A251	R:R:T246	1.68	No	Yes	0	6	7
514	E:E:G98	R:R:Q60	1.64	No	Yes	0	3	3
515	R:R:D103	R:R:P104	1.61	Yes	No	0	3	3
516	E:E:V125	E:E:V129	1.6	No	No	0	6	6
517	R:R:V310	R:R:V357	1.6	No	No	0	4	7
518	E:E:T128	E:E:V129	1.59	No	No	0	6	6
519	R:R:T325	R:R:V324	1.59	No	No	0	7	5
520	E:E:P105	R:R:Q61	1.58	No	No	0	6	3
521	L:L:L16	R:R:A145	1.58	Yes	No	0	0	4
522	R:R:A344	R:R:L323	1.58	No	No	0	9	9
523	R:R:T400	R:R:T401	1.57	No	No	0	4	7
524	E:E:C72	E:E:D71	1.56	No	Yes	0	9	8
525	R:R:I153	R:R:S157	1.55	No	No	0	7	7
526	R:R:I199	R:R:S195	1.55	No	Yes	0	7	7
527	R:R:I165	R:R:V164	1.54	No	No	0	5	4
528	R:R:I192	R:R:V164	1.54	Yes	No	0	7	4
529	R:R:I221	R:R:V217	1.54	No	No	0	4	3
530	R:R:I276	R:R:V272	1.54	No	No	0	5	4
531	R:R:I279	R:R:T275	1.52	No	No	0	3	3
532	R:R:M346	R:R:V342	1.52	No	No	0	8	8
533	R:R:M376	R:R:V375	1.52	Yes	No	0	7	4
534	E:E:A30	E:E:E29	1.51	No	No	0	4	4
535	R:R:K141	R:R:T138	1.5	No	No	0	3	2
536	R:R:L158	R:R:V154	1.49	No	No	0	4	6
537	R:R:L259	R:R:T182	1.47	Yes	No	0	5	5
538	R:R:L271	R:R:T275	1.47	No	No	0	4	3
539	R:R:I197	R:R:M229	1.46	No	No	0	5	4
540	R:R:A333	R:R:H336	1.46	No	No	0	5	6
541	R:R:G88	R:R:Y111	1.45	No	Yes	0	8	4
542	R:R:I347	R:R:K343	1.45	No	No	0	8	8
543	R:R:F359	R:R:P360	1.44	Yes	No	0	6	5
544	E:E:I118	E:E:L119	1.43	No	No	0	6	9
545	R:R:I200	R:R:L222	1.43	No	No	0	6	6
546	R:R:E329	R:R:T330	1.41	No	No	0	6	5
547	R:R:K370	R:R:N144	1.4	No	No	0	4	4
548	R:R:M367	R:R:N365	1.4	No	No	0	4	4
549	E:E:D47	E:E:M48	1.39	Yes	Yes	0	6	9
550	R:R:A136	R:R:F137	1.39	No	No	0	2	1
551	R:R:D97	R:R:K47	1.38	No	No	0	2	4
552	R:R:D50	R:R:K54	1.38	No	No	0	2	4
553	E:E:D58	E:E:L55	1.36	No	No	0	7	4
554	R:R:E114	R:R:K115	1.35	No	No	0	2	5
555	R:R:A51	R:R:Y98	1.33	No	Yes	0	8	4
556	R:R:E397	R:R:N396	1.31	No	No	0	9	6
557	E:E:D71	E:E:E68	1.3	Yes	No	0	8	4
558	R:R:H377	R:R:L151	1.29	Yes	No	0	7	5
559	L:L:R24	R:R:N135	1.21	No	No	0	0	3
560	E:E:D71	E:E:R67	1.19	Yes	No	0	8	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	E:E:Y32	6.61	4	0	7
2	E:E:D47	5.74	4	0	6
3	E:E:M48	8.37	4	8	9
4	E:E:Y66	11.56	5	4	9
5	E:E:D71	3.2175	4	0	8
6	E:E:T73	5.4925	4	0	9
7	E:E:F93	13.9925	4	4	9
8	E:E:H97	12.235	6	4	9
9	E:E:F101	10.0775	4	4	9
10	H:H:?1	10.104	5	1	0
11	L:L:C1	6.3525	4	2	0
12	L:L:S2	5.61	4	0	0
13	L:L:T6	4.8875	4	2	0
14	L:L:Q14	6.3525	4	0	0
15	L:L:L16	5.3225	4	0	0
16	L:L:H17	9.4075	4	3	0
17	L:L:K18	4.855	4	0	0
18	L:L:Y22	5.12857	7	3	0
19	L:L:T25	5.7975	4	1	0
20	L:L:P32	8.64667	6	1	0
21	L:L:?33	8.7	5	1	0
22	R:R:Y53	11.9675	4	4	1
23	R:R:Y56	14.7225	4	4	3
24	R:R:Q60	6.765	4	0	3
25	R:R:Y65	12.7883	6	9	3
26	R:R:D77	7.41	6	1	9
27	R:R:W79	11.7183	6	1	6
28	R:R:W82	9.745	4	0	9
29	R:R:P96	5.832	5	1	9
30	R:R:Y98	6.904	5	1	4
31	R:R:F99	11.5575	4	1	5
32	R:R:P100	7.01	4	0	4
33	R:R:F102	6.08286	7	1	4
34	R:R:D103	3.865	4	0	3
35	R:R:K110	11.518	5	1	8
36	R:R:Y111	8.4475	4	0	4
37	R:R:W118	11.832	5	1	9
38	R:R:H121	8.99	4	1	4
39	R:R:R126	7.17	4	1	4
40	R:R:W128	8.735	4	1	5
41	R:R:S129	7.5025	4	1	7
42	R:R:N130	9.306	5	1	8
43	R:R:Y131	7.70625	8	1	5
44	R:R:M133	8.5	4	1	5
45	R:R:Y149	6.314	5	0	5
46	R:R:F170	6	6	0	8
47	R:R:F173	4.562	5	0	7
48	R:R:L183	4.3525	4	0	8
49	R:R:Y191	7.90286	7	2	8
50	R:R:I192	3.488	5	0	7
51	R:R:S195	5.23	4	0	7
52	R:R:I198	6.5875	4	0	7
53	R:R:L211	5.24	4	3	1
54	R:R:Q227	6.9725	4	0	7
55	R:R:N233	8.5975	4	2	9
56	R:R:Y234	5.92833	6	2	7
57	R:R:F235	5.54	4	6	5
58	R:R:W236	7.62714	7	2	9
59	R:R:L238	5.776	5	0	8
60	R:R:E240	8.1775	4	0	9
61	R:R:I242	5.608	5	0	7
62	R:R:Y243	6.962	5	12	8
63	R:R:H245	11.8775	4	0	8
64	R:R:T246	6.1775	4	0	7
65	R:R:I248	3.725	4	0	7
66	R:R:L259	4.33	5	0	5
67	R:R:W261	8.8425	4	5	2
68	R:R:Y262	4.75	4	12	7
69	R:R:L265	5.25	4	6	7
70	R:R:W267	7.03	4	0	9
71	R:R:F269	6.964	5	6	3
72	R:R:P270	4.308	5	6	9
73	R:R:R281	9.82	4	0	7
74	R:R:D287	7.075	4	0	3
75	R:R:W290	11.766	5	13	9
76	R:R:L298	4.43	4	2	6
77	R:R:H302	7.75	5	2	6
78	R:R:P304	3.7175	4	0	9
79	R:R:F356	7.11571	7	2	7
80	R:R:F359	4.8425	4	10	6
81	R:R:Y372	8.7675	4	10	7
82	R:R:M376	6.295	4	10	7
83	R:R:H377	6.0225	4	0	7
84	R:R:Q383	8.1525	4	2	9
85	R:R:F385	6.6275	4	11	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	E:E:T73	E:E:Y32	10.4541	4.99	Yes	Yes	0	9	7
2	E:E:T73	E:E:W84	12.5293	12.13	Yes	No	0	9	9
3	E:E:P85	E:E:W84	14.5992	17.57	No	No	0	9	9
4	E:E:P85	R:R:G78	91.8513	4.06	No	No	0	9	5
5	R:R:D77	R:R:G78	24.8921	5.03	Yes	No	1	9	5
6	E:E:P85	R:R:W76	78.064	6.76	No	No	0	9	8
7	R:R:Q52	R:R:W76	76.1623	16.43	No	No	0	6	8
8	E:E:Y66	R:R:Q52	75.5283	5.64	Yes	No	0	9	6
9	E:E:F93	E:E:Y66	22.8263	14.44	Yes	Yes	4	9	9
10	E:E:H97	E:E:Y66	32.2225	13.07	Yes	Yes	4	9	9
11	E:E:F101	E:E:Y100	16.265	14.44	Yes	No	0	9	9
12	E:E:M48	E:E:Y100	13.56	23.95	Yes	No	0	9	9
13	E:E:Y66	R:R:Y53	14.0992	19.86	Yes	Yes	4	9	1
14	R:R:D57	R:R:Q60	10.8573	3.92	No	Yes	0	4	3
15	R:R:Q60	R:R:Y56	16.272	19.16	Yes	Yes	0	3	3
16	E:E:F93	R:R:Y56	20.8374	20.63	Yes	Yes	4	9	3
17	E:E:H97	R:R:Y56	21.0272	10.89	Yes	Yes	4	9	3
18	E:E:L94	R:R:Y56	24.3767	8.21	No	Yes	0	5	3
19	E:E:L94	R:R:M59	23.0274	7.07	No	No	0	5	5
20	L:L:P32	R:R:G78	67.5795	4.06	Yes	No	1	0	5
21	L:L:P32	R:R:W79	45.0153	20.27	Yes	Yes	1	0	6
22	R:R:F99	R:R:W79	22.4905	17.04	Yes	Yes	1	5	6
23	L:L:T25	R:R:F99	22.7992	7.78	Yes	Yes	1	0	5
24	L:L:T25	R:R:D101	100	5.78	Yes	No	0	0	4
25	R:R:D101	R:R:P100	99.9609	4.83	No	Yes	0	4	4
26	L:L:K18	R:R:P100	87.3165	5.02	Yes	Yes	0	0	4
27	L:L:K18	L:L:Q14	84.5083	4.07	Yes	Yes	0	0	0
28	L:L:Q14	R:R:V293	83.1537	5.73	Yes	No	0	0	6
29	R:R:L298	R:R:V293	83.1622	2.98	Yes	No	0	6	6
30	R:R:H302	R:R:L298	79.004	6.43	Yes	Yes	2	6	6
31	L:L:T6	R:R:H302	71.424	8.21	Yes	Yes	2	0	6
32	L:L:T6	R:R:Y234	71.406	3.75	Yes	Yes	2	0	7
33	R:R:N233	R:R:Y234	52.6335	3.49	Yes	Yes	2	9	7
34	R:R:N233	R:R:T190	38.2955	8.77	Yes	No	2	9	9
35	R:R:T190	R:R:W236	39.9095	4.85	No	Yes	2	9	9
36	R:R:C239	R:R:W236	12.3739	6.53	No	Yes	0	7	9
37	R:R:C239	R:R:L265	12.1092	4.76	No	Yes	0	7	7
38	R:R:F102	R:R:W79	22.5954	5.01	Yes	Yes	1	4	6
39	L:L:T25	R:R:F102	76.9703	6.49	Yes	Yes	1	0	4
40	L:L:P32	R:R:Y131	22.6394	5.56	Yes	Yes	1	0	5
41	R:R:F102	R:R:Y131	53.5884	3.09	Yes	Yes	1	4	5
42	R:R:D77	R:R:Y131	22.4698	6.9	Yes	Yes	1	9	5
43	R:R:L183	R:R:W236	19.4394	3.42	Yes	Yes	0	8	9
44	R:R:L183	R:R:Y243	15.9657	5.86	Yes	Yes	0	8	8
45	R:R:I242	R:R:Y262	10.028	4.84	Yes	Yes	0	7	7
46	L:L:?33	R:R:W128	10.1822	8.46	Yes	Yes	1	0	5
47	R:R:M59	R:R:R74	20.327	11.17	No	No	0	5	4
48	R:R:L62	R:R:R74	16.272	3.64	No	No	0	3	4
49	R:R:D84	R:R:L62	13.5658	4.07	No	No	0	4	3
50	R:R:D84	R:R:Y65	12.2118	16.09	No	Yes	0	4	3
51	L:L:K18	L:L:Y22	10.4427	3.58	Yes	Yes	0	0	0
52	L:L:H17	L:L:Y22	18.8963	6.53	Yes	Yes	3	0	0
53	R:R:N233	R:R:Y191	15.4929	13.96	Yes	Yes	2	9	8
54	R:R:V387	R:R:Y191	18.2067	6.31	No	Yes	0	9	8
55	R:R:F188	R:R:V387	17.6855	3.93	No	No	0	8	9
56	R:R:M237	R:R:Y234	15.5357	3.59	No	Yes	2	9	7
57	R:R:M237	R:R:Y191	15.1818	5.99	No	Yes	2	9	8
58	R:R:F170	R:R:F188	10.0355	6.43	Yes	No	0	8	8
59	R:R:M187	R:R:Y191	12.703	5.99	No	Yes	0	8	8
60	R:R:E240	R:R:M187	12.2754	10.83	Yes	No	0	9	8
61	R:R:C219	R:R:C289	15.4322	7.28	No	No	3	9	9
62	R:R:C219	R:R:L211	11.2257	3.17	No	Yes	3	9	1
63	R:R:E240	R:R:L351	11.3231	9.28	Yes	No	0	9	9
64	R:R:L351	R:R:Y391	10.8141	11.72	No	No	0	9	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
E:E:P85	R:R:G78	4.06	0	No	No	9	5	2	1
H:H:?1	R:R:H121	4.61	1	Yes	Yes	0	4	2	2
H:H:?1	R:R:W128	7.15	1	Yes	Yes	0	5	2	1
H:H:?1	R:R:N130	24.64	1	Yes	Yes	0	8	2	2
L:L:C1	R:R:L298	3.17	2	Yes	Yes	0	6	0	1
L:L:C1	R:R:H302	11.79	2	Yes	Yes	0	6	0	1
L:L:S2	R:R:V293	3.23	0	Yes	No	0	6	0	1
L:L:S2	R:R:E294	8.62	0	Yes	No	0	3	0	1
L:L:N3	R:R:W361	14.69	0	No	No	0	4	0	1
L:L:L4	R:R:M306	5.65	0	No	No	0	4	0	1
L:L:S5	R:R:F356	7.93	0	No	Yes	0	7	0	1
L:L:S5	R:R:M376	3.07	0	No	Yes	0	7	0	1
L:L:T6	R:R:Y234	3.75	2	Yes	Yes	0	7	0	1
L:L:T6	R:R:H302	8.21	2	Yes	Yes	0	6	0	1
L:L:T6	R:R:V305	3.17	2	Yes	No	0	7	0	1
L:L:C7	R:R:H302	7.37	2	No	Yes	0	6	0	1
L:L:V8	R:R:H377	5.54	0	No	Yes	0	7	0	1
L:L:L9	R:R:I198	7.14	0	No	Yes	0	7	0	1
L:L:L9	R:R:H226	3.86	0	No	No	0	6	0	1
L:L:L12	R:R:H377	7.71	0	No	Yes	0	7	0	1
L:L:S13	R:R:V206	3.23	0	No	No	0	3	0	1
L:L:Q14	R:R:V293	5.73	0	Yes	No	0	6	0	1
L:L:Q14	R:R:E294	10.19	0	Yes	No	0	3	0	1
L:L:L16	R:R:Y146	9.38	0	Yes	No	0	2	0	1
L:L:L16	R:R:Y149	5.86	0	Yes	Yes	0	5	0	1
L:L:L16	R:R:V206	4.47	0	Yes	No	0	3	0	1
L:L:H17	R:R:V212	11.07	3	Yes	No	0	3	0	1
L:L:H17	R:R:L291	7.71	3	Yes	No	0	6	0	1
L:L:K18	R:R:P100	5.02	0	Yes	Yes	0	4	0	1
L:L:Q20	R:R:L142	10.65	0	No	No	0	2	0	1
L:L:Q20	R:R:Y146	10.15	0	No	No	0	2	0	1
L:L:T21	R:R:G209	3.64	3	No	No	0	3	0	1
L:L:Y22	R:R:P38	4.17	3	Yes	No	0	5	0	1
L:L:Y22	R:R:L40	3.52	3	Yes	No	0	5	0	1
L:L:Y22	R:R:Y41	8.94	3	Yes	No	0	3	0	1
L:L:T25	R:R:F99	7.78	1	Yes	Yes	0	5	0	1
L:L:T25	R:R:D101	5.78	1	Yes	No	0	4	0	1
L:L:T25	R:R:F102	6.49	1	Yes	Yes	0	4	0	1
L:L:T27	R:R:N135	8.77	0	No	No	0	3	0	1
L:L:S29	R:R:E123	14.37	0	No	No	0	4	0	1
L:L:P32	R:R:D77	8.05	1	Yes	Yes	0	9	0	1
L:L:P32	R:R:G78	4.06	1	Yes	No	0	5	0	1
L:L:P32	R:R:W79	20.27	1	Yes	Yes	0	6	0	1
L:L:P32	R:R:Y131	5.56	1	Yes	Yes	0	5	0	1
L:L:?33	R:R:D77	6.72	1	Yes	Yes	0	9	0	1
L:L:?33	R:R:W128	8.46	1	Yes	Yes	0	5	0	1
L:L:?33	R:R:S129	7.43	1	Yes	Yes	0	7	0	1
L:L:?33	R:R:Y131	8.7	1	Yes	Yes	0	5	0	1
R:R:P38	R:R:Y41	8.34	3	No	No	5	3	1	1
R:R:L40	R:R:P100	9.85	0	No	Yes	5	4	1	1
R:R:P100	R:R:Y41	8.34	0	Yes	No	4	3	1	1
R:R:M48	R:R:R45	6.2	0	No	No	6	7	2	2
R:R:F99	R:R:R45	9.62	1	Yes	No	5	7	1	2
R:R:M48	R:R:W79	4.65	0	No	Yes	6	6	2	1
R:R:D77	R:R:G78	5.03	1	Yes	No	9	5	1	1
R:R:D77	R:R:W82	8.93	1	Yes	Yes	9	9	1	2
R:R:D77	R:R:S129	8.83	1	Yes	Yes	9	7	1	1
R:R:D77	R:R:Y131	6.9	1	Yes	Yes	9	5	1	1
R:R:P96	R:R:W79	4.05	1	Yes	Yes	9	6	2	1
R:R:F99	R:R:W79	17.04	1	Yes	Yes	5	6	1	1
R:R:F102	R:R:W79	5.01	1	Yes	Yes	4	6	1	1
R:R:W79	R:R:Y131	19.29	1	Yes	Yes	6	5	1	1
R:R:V108	R:R:W82	3.68	0	No	Yes	7	9	2	2
R:R:K110	R:R:W82	20.89	1	Yes	Yes	8	9	2	2
R:R:F102	R:R:P96	5.78	1	Yes	Yes	4	9	1	2
R:R:P96	R:R:Y131	4.17	1	Yes	Yes	9	5	2	1
R:R:F102	R:R:F99	11.79	1	Yes	Yes	4	5	1	1
R:R:D101	R:R:P100	4.83	0	No	Yes	4	4	1	1
R:R:F102	R:R:Y131	3.09	1	Yes	Yes	4	5	1	1
R:R:C134	R:R:F102	5.59	0	No	Yes	9	4	2	1
R:R:F102	R:R:N135	4.83	1	Yes	No	4	3	1	1
R:R:D103	R:R:K141	5.53	0	Yes	No	3	3	2	1
R:R:V108	R:R:Y131	6.31	0	No	Yes	7	5	2	1
R:R:K110	R:R:S129	6.12	1	Yes	Yes	8	7	2	1
R:R:E123	R:R:H121	7.39	0	No	Yes	4	4	1	2
R:R:H121	R:R:W128	14.81	1	Yes	Yes	4	5	2	1
R:R:N130	R:R:W128	4.52	1	Yes	Yes	8	5	2	1
R:R:S129	R:R:Y131	7.63	1	Yes	Yes	7	5	1	1
R:R:Y146	R:R:Y150	4.96	0	No	No	2	4	1	2
R:R:Y149	R:R:Y150	8.94	0	Yes	No	5	4	1	2
R:R:I153	R:R:Y149	6.04	0	No	Yes	7	5	2	1
R:R:L202	R:R:Y149	8.21	0	No	Yes	7	5	2	1
R:R:H156	R:R:I198	9.28	0	No	Yes	7	7	2	1
R:R:H156	R:R:H381	13.14	0	No	No	7	9	2	2
R:R:I198	R:R:N194	7.08	0	Yes	No	7	8	1	2
R:R:N194	R:R:N233	8.17	0	No	Yes	8	9	2	2
R:R:P207	R:R:V206	3.53	0	No	No	3	3	2	1
R:R:G209	R:R:R213	4.5	0	No	No	3	2	1	2
R:R:C289	R:R:V212	8.54	3	No	No	9	3	2	1
R:R:L291	R:R:V212	2.98	3	No	No	6	3	1	1
R:R:H226	R:R:Q227	4.95	0	No	Yes	6	7	1	2
R:R:H226	R:R:M230	5.25	0	No	No	6	6	1	2
R:R:H302	R:R:Q227	4.95	2	Yes	Yes	6	7	1	2
R:R:M230	R:R:Y234	4.79	0	No	Yes	6	7	2	1
R:R:N233	R:R:Y234	3.49	2	Yes	Yes	9	7	2	1
R:R:M237	R:R:Y234	3.59	2	No	Yes	9	7	2	1
R:R:V305	R:R:Y234	7.57	2	No	Yes	7	7	1	1
R:R:F356	R:R:Y234	12.38	2	Yes	Yes	7	7	1	1
R:R:M237	R:R:Q383	5.44	2	No	Yes	9	9	2	2
R:R:H277	R:R:L298	5.14	0	No	Yes	7	6	2	1
R:R:C289	R:R:L291	3.17	3	No	No	9	6	2	1
R:R:L298	R:R:V293	2.98	2	Yes	No	6	6	1	1
R:R:H302	R:R:L298	6.43	2	Yes	Yes	6	6	1	1
R:R:F356	R:R:L309	3.65	2	Yes	No	7	7	1	2
R:R:G353	R:R:Q355	4.93	2	No	No	9	8	2	2
R:R:F356	R:R:G353	3.01	2	Yes	No	7	9	1	2
R:R:F356	R:R:Q355	9.37	2	Yes	No	7	8	1	2
R:R:Q355	R:R:Q383	8.96	2	No	Yes	8	9	2	2
R:R:F356	R:R:I380	8.79	2	Yes	No	7	6	1	2
R:R:F356	R:R:Q383	4.68	2	Yes	Yes	7	9	1	2
R:R:F359	R:R:Y372	5.16	10	Yes	Yes	6	7	2	2
R:R:F359	R:R:M376	6.22	10	Yes	Yes	6	7	2	1
R:R:M376	R:R:Y372	14.37	10	Yes	Yes	7	7	1	2
R:R:H377	R:R:H381	9.55	0	Yes	No	7	9	1	2
R:R:I198	R:R:L202	2.85	0	Yes	No	7	7	1	2
L:L:L19	R:R:K141	2.82	0	No	No	0	3	0	1
R:R:V203	R:R:Y149	2.52	0	No	Yes	3	5	2	1
L:L:L16	R:R:A145	1.58	0	Yes	No	0	4	0	1
R:R:M376	R:R:V375	1.52	10	Yes	No	7	4	1	2
R:R:K141	R:R:T138	1.5	0	No	No	3	2	1	2
R:R:H377	R:R:L151	1.29	0	Yes	No	7	5	1	2
L:L:R24	R:R:N135	1.21	0	No	No	0	3	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7TYW_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.98
Number of Linked Nodes	479
Number of Links	560
Number of Hubs	85
Number of Links mediated by Hubs	312
Number of Communities	14
Number of Nodes involved in Communities	98
Number of Links involved in Communities	137

Path Summary
Number Of Nodes in MetaPath	65
Number Of Links MetaPath	64
Number of Shortest Paths	459201
Length Of Smallest Path	3
Average Path Length	23.6065
Length of Longest Path	45
Minimum Path Strength	1.245
Average Path Strength	7.0178
Maximum Path Strength	28.895
Minimum Path Correlation	0.7
Average Path Correlation	0.968202
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	4.16667
Average % Of Corr. Nodes	50.2716
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	54.7888
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• calcitonin family binding • calcitonin gene-related peptide binding • amide binding • binding • peptide hormone binding • hormone binding • molecular transducer activity • coreceptor activity • signaling receptor activity • calcitonin family receptor activity • peptide receptor activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • transmembrane signaling receptor activity • calcitonin gene-related peptide receptor activity • amylin receptor activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • cellular localization • establishment of protein localization
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • cellular localization • establishment of protein localization • nitrogen compound transport • transport • intracellular transport • establishment of localization • localization • protein transport • establishment of localization in cell • macromolecule localization • intracellular protein localization • intracellular protein transport • regulation of signaling • regulation of signal transduction • regulation of response to stimulus • regulation of cell communication • regulation of G protein-coupled receptor signaling pathway • import into cell • receptor internalization • receptor-mediated endocytosis • endocytosis • vesicle-mediated transport • developmental process • multicellular organismal process • blood vessel morphogenesis • tube development • angiogenesis • vasculature development • circulatory system development • anatomical structure morphogenesis • multicellular organism development • tube morphogenesis • anatomical structure formation involved in morphogenesis • anatomical structure development • blood vessel development • system development • calcitonin family receptor signaling pathway • calcitonin gene-related peptide receptor signaling pathway • amylin receptor signaling pathway • monoatomic ion transport • monoatomic cation transport • calcium ion transport • metal ion transport • protein localization to cell periphery • protein localization to plasma membrane • localization within membrane • protein localization to membrane • amylin receptor 1 signaling pathway • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to endogenous stimulus • response to chemical • cellular response to hormone stimulus • protein-containing complex • receptor complex • cell surface • cellular anatomical structure • cell periphery • plasma membrane • membrane • plasma membrane protein complex • membrane protein complex • plasma membrane signaling receptor complex • G protein-coupled receptor complex • CGRP receptor complex • calcitonin family receptor complex • calcitonin receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • hormone activity • molecular function activator activity • molecular function regulator activity • signaling receptor regulator activity • receptor ligand activity • signaling receptor activator activity • extracellular region • extracellular space • amide binding • amyloid-beta binding • peptide binding • calcitonin family receptor activity • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • calcitonin receptor activity • amylin receptor activity • calcitonin gene-related peptide receptor activity • calcitonin binding • calcitonin family binding • peptide hormone binding • hormone binding • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • positive regulation of cell communication • positive regulation of signal transduction • positive regulation of biological process • intracellular signal transduction • positive regulation of response to stimulus • regulation of intracellular signal transduction • intracellular signaling cassette • regulation of calcium-mediated signaling • positive regulation of calcium-mediated signaling • positive regulation of cellular process • positive regulation of intracellular signal transduction • calcium-mediated signaling • positive regulation of signaling • catabolic process • negative regulation of biological process • RNA metabolic process • macromolecule catabolic process • regulation of primary metabolic process • nucleobase-containing compound metabolic process • post-transcriptional regulation of gene expression • regulation of RNA metabolic process • regulation of mRNA catabolic process • negative regulation of cellular process • regulation of nucleobase-containing compound metabolic process • RNA catabolic process • negative regulation of macromolecule metabolic process • regulation of biosynthetic process • mRNA catabolic process • negative regulation of metabolic process • primary metabolic process • regulation of macromolecule metabolic process • regulation of catabolic process • gene expression • mRNA metabolic process • macromolecule biosynthetic process • nucleic acid metabolic process • nucleobase-containing compound catabolic process • regulation of mRNA stability • regulation of gene expression • negative regulation of gene expression • biosynthetic process • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • regulation of RNA stability • nucleic acid catabolic process • metabolic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • regulation of mRNA metabolic process • regulation of metabolic process • positive regulation of ERK1 and ERK2 cascade • positive regulation of MAPK cascade • regulation of MAPK cascade • MAPK cascade • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of macromolecule biosynthetic process • positive regulation of metabolic process • positive regulation of gene expression • positive regulation of biosynthetic process • positive regulation of macromolecule metabolic process • regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • phosphatidylinositol 3-kinase/protein kinase B signal transduction • response to corticosteroid • response to lipid • response to steroid hormone • response to glucocorticoid • response to oxygen-containing compound • response to nitrogen compound • response to amyloid-beta • cell surface receptor signaling pathway • ossification • amylin receptor 2 signaling pathway • myeloid leukocyte differentiation • cellular developmental process • hemopoiesis • cell development • myeloid cell differentiation • cell differentiation • osteoclast differentiation • leukocyte differentiation • positive regulation of cAMP/PKA signal transduction • cAMP/PKA signal transduction • regulation of cAMP/PKA signal transduction • regulation of multicellular organismal process • negative regulation of multicellular organismal process • regulation of ossification • negative regulation of ossification • amylin receptor 3 signaling pathway • membrane-bounded organelle • cell projection • organelle • cilium • plasma membrane bounded cell projection • amylin receptor complex • amylin receptor complex 3 • amylin receptor complex 2 • amylin receptor complex 1 • axon • neuron projection • acrosomal vesicle • intracellular anatomical structure • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle • secretory granule • secretory vesicle • cytoplasm • vesicle • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • skin development • skin epidermis development • hair follicle development • molting cycle • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to nitrogen compound • response to peptide hormone • cellular response to peptide hormone stimulus • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • skeletal system development • bone development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • homeostatic process • adaptive thermogenesis • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • regulation of localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • hormone secretion • protein localization to extracellular region • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • regulation of peptide hormone secretion • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • cell-cell signaling • regulation of protein transport • protein secretion • regulation of protein secretion • regulation of secretion • peptide transport • regulation of insulin secretion • peptide hormone secretion • hormone transport • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • extrinsic component of plasma membrane • catalytic complex • cytoplasmic side of membrane • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular membrane-bounded organelle • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • trans-Golgi network • organelle membrane • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of taste • sensory organ development • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • cell population proliferation • small GTPase-mediated signal transduction • Ras protein signal transduction • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• RAMP1-like • G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• RAMP1-like • G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	NAG
PDB Residues	H:H:?1 H:H:?2
Environment Details	Open EMBL-EBI Page
Code	NAG
Name	N-Acetylglucosamine
Synonyms	N-Acetylglucosamine
Identifier
Formula	C8 H15 N O6
Molecular Weight	221.208
SMILES
PubChem	24139
Formal Charge	0
Total Atoms	30
Total Chiral Atoms	5
Total Bonds	30
Total Aromatic Bonds	0


Code	NH2
PDB Residues	L:L:?33
Environment Details	Open EMBL-EBI Page
Code	NH2
Name	AMINO GROUP
Synonyms
Identifier
Formula	H2 N
Molecular Weight	16.023
SMILES
PubChem	123329
Formal Charge	0
Total Atoms	3
Total Chiral Atoms	0
Total Bonds	2
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	E
Protein	RAMP1
UniProt	O60894
Sequence	>7TYW_nogp_Chain_E C Q E A N Y G A L L R E L C L T Q F Q V D M E A V G E T L W C D W G R T I R S Y R E L A D C T W H M A E K L G C F W P N A E V D R F F L A V H G R Y F R S C P I S I L Y P F I V V P I T V T L L V T A L V V W Q S K R T Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	R
Protein	Receptor
UniProt	P30988
Sequence	>7TYW_nogp_Chain_R P F L Y V V G R K K M M D A Q Y K C Y D R M Q Q L P A Y Q G E G P Y C N R T W D G W L C W D D T P A G V L S Y Q F C P D Y F P D F D P S E K V T K Y C D E K G V W F K H P E N N R T W S N Y T M C N A F T P E K L K N A Y V L Y Y L A I V G H S L S I F T L V I S L G I F V F F R S L G C Q R V T L H K N M F L T Y I L N S M I I I I H L V E V V P N G E L V R R D P V S C K I L H F F H Q Y M M A C N Y F W M L C E G I Y L H T L I V V A V F T E K Q R L R W Y Y L L G W G F P L V P T T I H A I T R A V Y F N D N C W L S V E T H L L Y I I H G P V M A A L V V N F F F L L N I V R V L V T K M R E T H E A E S H M Y L K A V K A T M I L V P L L G I Q F V V F P W R P S N K M L G K I Y D Y V M H S L I H F Q G F F V A T I Y C F C N N E V Q T T V K R Q W A Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9AUC	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Calcitonin gene-related peptide-1	-	Gs/β1/γ2; RAMP1	2.4	2024-04-24	doi.org/10.1021/acs.biochem.4c00114
	9AUC (No Gprot)	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Calcitonin gene-related peptide-1	-		2.4	2024-04-24	doi.org/10.1021/acs.biochem.4c00114
	7TYF	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Amylin	-	Gs/β1/γ2; RAMP1	2.2	2022-03-23	doi.org/10.1126/science.abm9609
	7TYF (No Gprot)	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Amylin	-		2.2	2022-03-23	doi.org/10.1126/science.abm9609
	7TYW	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Calcitonin-1	-	Gs/β1/γ2; RAMP1	3	2022-03-23	doi.org/10.1126/science.abm9609
	7TYW (No Gprot)	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Calcitonin-1	-		3	2022-03-23	doi.org/10.1126/science.abm9609
	9BLW	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Cagrilintide backbone (non-acylated)	-	Gs/β1/γ2; RAMP1	3.2	2025-04-16	To be published
	9BLW (No Gprot)	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Cagrilintide backbone (non-acylated)	-		3.2	2025-04-16	To be published
	9BP3	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Cagrilintide	-	Gs/β1/γ2; RAMP1	2.2	2025-04-23	To be published
	9BP3 (No Gprot)	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Cagrilintide	-		2.2	2025-04-23	To be published

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