psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	E:E:R37	E:E:Y32	14.4	Yes	Yes	1	3	5
2	E:E:M76	E:E:Y32	19.16	Yes	Yes	1	4	5
3	E:E:C82	E:E:Y32	5.38	No	Yes	0	8	5
4	E:E:V89	E:E:Y32	3.79	Yes	Yes	1	8	5
5	E:E:A34	E:E:E88	3.02	No	No	0	2	4
6	E:E:L36	E:E:L39	4.15	No	No	0	5	1
7	E:E:L36	E:E:M76	16.96	No	Yes	0	5	4
8	E:E:R37	E:E:T73	14.23	Yes	No	1	3	9
9	E:E:M76	E:E:R37	3.72	Yes	Yes	1	4	3
10	E:E:R37	E:E:V89	15.69	Yes	Yes	1	3	8
11	E:E:F92	E:E:R37	29.93	Yes	Yes	1	5	3
12	E:E:F93	E:E:R37	5.34	Yes	Yes	1	9	3
13	E:E:E38	E:E:L39	7.95	No	No	0	4	1
14	E:E:E38	E:E:T42	4.23	No	No	0	4	2
15	E:E:C40	E:E:C72	7.28	No	No	0	9	9
16	E:E:F92	E:E:L41	4.87	Yes	No	1	5	5
17	E:E:L41	E:E:V96	2.98	No	No	1	5	8
18	E:E:F44	E:E:S65	5.28	No	No	0	9	4
19	E:E:F44	E:E:L69	19.49	No	No	0	9	8
20	E:E:F44	E:E:Y100	8.25	No	Yes	0	9	8
21	E:E:E49	E:E:Q45	6.37	No	No	0	3	4
22	E:E:Q45	E:E:R99	14.02	No	No	1	4	4
23	E:E:Q45	E:E:Y100	5.64	No	Yes	1	4	8
24	E:E:D47	E:E:S65	10.31	No	No	0	5	4
25	E:E:M48	E:E:W56	8.14	No	No	1	9	5
26	E:E:M48	E:E:T62	6.02	No	No	0	9	8
27	E:E:M48	E:E:Y100	13.17	No	Yes	1	9	8
28	E:E:L55	E:E:V51	7.45	No	No	0	5	5
29	E:E:L55	E:E:T54	2.95	No	No	0	5	4
30	E:E:D58	E:E:L55	5.43	No	No	0	5	5
31	E:E:W56	E:E:Y100	8.68	No	Yes	1	5	8
32	E:E:C104	E:E:C57	7.28	No	No	0	9	9
33	E:E:I63	E:E:W59	9.4	No	Yes	0	5	7
34	E:E:S107	E:E:W59	7.41	No	Yes	0	6	7
35	E:E:W59	R:R:D50	3.35	Yes	No	0	7	2
36	E:E:W59	R:R:Y53	6.75	Yes	Yes	0	7	1
37	E:E:S65	E:E:T62	3.2	No	No	0	4	8
38	E:E:F93	E:E:Y66	8.25	Yes	Yes	1	9	9
39	E:E:H97	E:E:Y66	10.89	Yes	Yes	1	9	9
40	E:E:Y66	R:R:M49	3.59	Yes	No	0	9	4
41	E:E:Y66	R:R:Q52	4.51	Yes	Yes	1	9	6
42	E:E:Y66	R:R:Y53	2.98	Yes	Yes	1	9	1
43	E:E:Y66	R:R:Y56	3.97	Yes	Yes	1	9	3
44	E:E:D71	E:E:R67	7.15	No	No	0	3	5
45	E:E:R67	R:R:R45	4.26	No	No	0	5	7
46	E:E:F92	E:E:L69	7.31	Yes	No	1	5	8
47	E:E:L69	E:E:V96	2.98	No	No	1	8	8
48	E:E:A70	R:R:M49	3.22	No	No	0	8	4
49	E:E:D71	E:E:W74	5.58	No	Yes	12	3	6
50	E:E:D71	E:E:H75	15.13	No	No	12	3	2
51	E:E:F93	E:E:T73	5.19	Yes	No	1	9	9
52	E:E:H75	E:E:W74	7.41	No	Yes	12	2	6
53	E:E:E78	E:E:W74	10.9	No	Yes	12	4	6
54	E:E:W74	E:E:W84	6.56	Yes	Yes	0	6	7
55	E:E:E78	E:E:H75	4.92	No	No	12	4	2
56	E:E:A77	E:E:W84	3.89	No	Yes	0	8	7
57	E:E:E78	E:E:K79	4.05	No	No	0	4	2
58	E:E:K79	E:E:L80	4.23	No	No	0	2	6
59	E:E:F83	R:R:N124	4.83	No	Yes	8	5	5
60	E:E:F83	R:R:R126	20.31	No	No	8	5	4
61	E:E:P85	E:E:W84	8.11	No	Yes	0	9	7
62	E:E:V89	E:E:W84	3.68	Yes	Yes	0	8	7
63	E:E:P85	R:R:G78	4.06	No	No	0	9	5
64	E:E:D90	E:E:V89	2.92	No	Yes	0	8	8
65	E:E:D90	R:R:Y56	6.9	No	Yes	0	8	3
66	E:E:D90	R:R:T75	2.89	No	No	0	8	5
67	E:E:R91	H:H:?503	4.36	No	No	0	3	0
68	E:E:F92	E:E:F93	5.36	Yes	Yes	1	5	9
69	E:E:F92	E:E:V96	5.24	Yes	No	1	5	8
70	E:E:F93	R:R:Q52	7.03	Yes	Yes	1	9	6
71	E:E:F93	R:R:Y56	17.54	Yes	Yes	1	9	3
72	E:E:F101	E:E:H97	7.92	Yes	Yes	1	9	9
73	E:E:H97	R:R:Y53	5.44	Yes	Yes	1	9	1
74	E:E:H97	R:R:Y56	6.53	Yes	Yes	1	9	3
75	E:E:H97	R:R:Q60	4.95	Yes	No	0	9	3
76	E:E:G98	R:R:Q60	4.93	No	No	0	5	3
77	E:E:R99	E:E:Y100	23.66	No	Yes	1	4	8
78	E:E:F101	E:E:Y100	4.13	Yes	Yes	1	9	8
79	E:E:F101	R:R:Y53	10.32	Yes	Yes	1	9	1
80	E:E:R102	E:E:S103	3.95	No	No	0	5	7
81	E:E:S103	R:R:Q61	2.89	No	No	0	7	3
82	E:E:C104	E:E:P105	5.65	No	No	0	9	7
83	E:E:V111	R:R:F285	7.87	No	Yes	0	5	6
84	E:E:D113	E:E:P114	4.83	Yes	Yes	3	9	9
85	E:E:D113	R:R:F285	5.97	Yes	Yes	3	9	6
86	E:E:D113	R:R:T295	8.67	Yes	Yes	3	9	4
87	E:E:D113	R:R:H296	5.04	Yes	No	0	9	2
88	E:E:I118	E:E:P114	5.08	No	Yes	3	7	9
89	E:E:L119	E:E:P114	3.28	No	Yes	0	8	9
90	E:E:P114	R:R:Y284	13.91	Yes	No	3	9	2
91	E:E:P114	R:R:L297	3.28	Yes	Yes	3	9	4
92	E:E:P115	E:E:S117	3.56	No	No	0	9	4
93	E:E:G116	E:E:Y120	2.9	No	No	0	5	5
94	E:E:I118	R:R:Y284	3.63	No	No	3	7	2
95	E:E:F122	R:R:T280	7.78	No	No	3	9	4
96	E:E:F122	R:R:I300	3.77	No	No	3	9	8
97	E:E:I123	R:R:Y299	3.63	No	Yes	0	9	7
98	E:E:P126	E:E:V125	3.53	No	No	0	9	6
99	E:E:I127	R:R:G303	3.53	No	No	6	8	4
100	E:E:I127	R:R:P304	3.39	No	Yes	6	8	9
101	E:E:T130	R:R:F235	3.89	No	Yes	6	9	5
102	E:E:T130	R:R:F269	9.08	No	Yes	6	9	3
103	E:E:T130	R:R:P304	6.99	No	Yes	6	9	9
104	E:E:V133	R:R:F269	6.55	No	Yes	0	8	3
105	E:E:T134	R:R:L238	4.42	No	Yes	0	8	8
106	E:E:V137	R:R:I242	3.07	No	Yes	0	9	7
107	E:E:V137	R:R:L265	5.96	No	Yes	0	9	7
108	E:E:V138	R:R:I242	4.61	No	Yes	0	9	7
109	E:E:Q140	E:E:W139	6.57	No	No	0	8	6
110	E:E:Q140	E:E:R143	4.67	No	No	0	8	7
111	E:E:Q140	R:R:W261	19.71	No	Yes	0	8	2
112	E:E:S141	R:R:T246	7.99	Yes	No	9	9	7
113	E:E:S141	R:R:Q257	2.89	Yes	Yes	9	9	5
114	E:E:S141	R:R:Y262	3.82	Yes	Yes	9	9	7
115	E:E:T144	R:R:T254	10.99	No	No	0	7	6
116	H:H:?501	R:R:N125	29.57	No	No	0	0	7
117	H:H:?502	R:R:W128	6.13	No	Yes	5	0	5
118	H:H:?502	R:R:N130	24.64	No	Yes	5	0	8
119	H:H:?502	R:R:M133	5.07	No	No	5	0	5
120	H:H:?503	R:R:Y71	7.36	No	No	0	0	3
121	H:H:?503	R:R:N73	28.34	No	No	0	0	4
122	L:L:?0	L:L:K1	5.05	No	No	0	0	0
123	L:L:?0	L:L:?101	36.11	No	No	0	0	0
124	L:L:?0	R:R:Y299	3.15	No	Yes	0	0	7
125	L:L:K1	R:R:E294	10.8	No	No	0	0	3
126	L:L:K1	R:R:H296	5.24	No	No	0	0	2
127	L:L:C2	L:L:C7	7.28	No	No	4	0	0
128	L:L:C2	R:R:L298	4.76	No	No	0	0	6
129	L:L:C2	R:R:H302	4.42	No	Yes	4	0	6
130	L:L:N3	L:L:R11	4.82	No	No	0	0	0
131	L:L:N3	R:R:W361	15.82	No	No	0	0	4
132	L:L:T4	L:L:T6	4.71	No	Yes	4	0	0
133	L:L:T4	R:R:Y299	3.75	No	Yes	0	0	7
134	L:L:T4	R:R:H302	5.48	No	Yes	4	0	6
135	L:L:A5	R:R:F356	5.55	No	Yes	0	0	7
136	L:L:T6	R:R:Y234	8.74	Yes	Yes	4	0	7
137	L:L:T6	R:R:H302	8.21	Yes	Yes	4	0	6
138	L:L:T6	R:R:F356	3.89	Yes	Yes	4	0	7
139	L:L:C7	R:R:H302	5.9	No	Yes	4	0	6
140	L:L:A8	R:R:H377	2.93	No	Yes	0	0	7
141	L:L:T9	R:R:H381	6.85	No	Yes	0	0	9
142	L:L:Q10	R:R:H226	3.71	No	Yes	0	0	6
143	L:L:L12	L:L:L16	5.54	No	No	0	0	0
144	L:L:L12	R:R:L148	4.15	No	No	15	0	5
145	L:L:L12	R:R:H377	7.71	No	Yes	15	0	7
146	L:L:A13	R:R:H201	2.93	No	Yes	0	0	6
147	L:L:E14	L:L:R17	12.79	No	No	16	0	0
148	L:L:E14	R:R:L291	3.98	No	No	16	0	6
149	L:L:E14	R:R:V293	5.7	No	No	0	0	6
150	L:L:F15	L:L:S19	7.93	Yes	No	0	0	0
151	L:L:F15	R:R:K141	19.85	Yes	No	0	0	3
152	L:L:F15	R:R:L142	3.65	Yes	No	0	0	2
153	L:L:L16	R:R:A145	3.15	No	No	0	0	4
154	L:L:L16	R:R:Y149	3.52	No	Yes	0	0	5
155	L:L:R17	R:R:V212	5.23	No	No	0	0	3
156	L:L:R17	R:R:L291	8.5	No	No	16	0	6
157	L:L:H18	L:L:S19	4.18	No	No	0	0	0
158	L:L:H18	R:R:P104	3.05	No	No	0	0	3
159	L:L:F23	L:L:S20	6.61	No	No	18	0	0
160	L:L:S20	R:R:Y146	5.09	No	No	18	0	2
161	L:L:G24	L:L:N21	5.09	No	No	0	0	0
162	L:L:F23	R:R:Y146	7.22	No	No	18	0	2
163	L:L:F23	R:R:P207	5.78	No	No	0	0	3
164	L:L:G24	L:L:P25	4.06	No	No	0	0	0
165	L:L:L27	L:L:P28	4.93	No	No	0	0	0
166	L:L:P29	R:R:N135	4.89	No	No	0	0	3
167	L:L:T30	R:R:F99	14.27	No	Yes	0	0	5
168	L:L:T30	R:R:D101	8.67	No	Yes	0	0	4
169	L:L:N31	L:L:N35	5.45	No	No	19	0	0
170	L:L:N31	L:L:T36	4.39	No	Yes	19	0	0
171	L:L:S34	R:R:H121	8.37	No	No	0	0	4
172	L:L:S34	R:R:E123	8.62	No	No	8	0	4
173	L:L:S34	R:R:N124	7.45	No	Yes	8	0	5
174	L:L:N35	L:L:T36	2.92	No	Yes	19	0	0
175	L:L:P37	L:L:T36	3.5	Yes	Yes	0	0	0
176	L:L:?38	L:L:P37	4.06	Yes	Yes	0	0	0
177	L:L:P37	R:R:W79	17.57	Yes	Yes	0	0	6
178	L:L:P37	R:R:R126	2.88	Yes	No	0	0	4
179	L:L:?38	R:R:D77	10.08	Yes	Yes	2	0	9
180	L:L:?38	R:R:S129	7.43	Yes	Yes	2	0	7
181	L:L:?38	R:R:Y131	2.9	Yes	Yes	2	0	5
182	L:L:?101	R:R:W361	7.37	No	No	0	0	4
183	R:R:D97	R:R:K47	11.06	No	No	0	2	4
184	R:R:K47	R:R:Y98	7.17	No	Yes	0	4	4
185	R:R:M48	R:R:W79	4.65	No	Yes	2	6	6
186	R:R:M48	R:R:Y98	10.78	No	Yes	2	6	4
187	R:R:D50	R:R:K54	9.68	No	No	0	2	4
188	R:R:Q52	R:R:Y56	7.89	Yes	Yes	1	6	3
189	R:R:Q52	R:R:W76	14.24	Yes	Yes	1	6	8
190	R:R:C55	R:R:M59	3.24	No	Yes	1	9	5
191	R:R:C55	R:R:W76	10.45	No	Yes	1	9	8
192	R:R:C55	R:R:C81	7.28	No	No	1	9	9
193	R:R:W76	R:R:Y56	7.72	Yes	Yes	1	8	3
194	R:R:D57	R:R:Q61	7.83	No	No	0	4	3
195	R:R:L62	R:R:R58	7.29	No	No	0	3	3
196	R:R:D83	R:R:R58	10.72	No	No	0	5	3
197	R:R:M59	R:R:R74	8.69	Yes	No	0	5	4
198	R:R:C81	R:R:M59	3.24	No	Yes	1	9	5
199	R:R:Q60	R:R:Q61	6.4	No	No	0	3	3
200	R:R:L62	R:R:P63	3.28	No	No	0	3	1
201	R:R:L62	R:R:R74	4.86	No	No	0	3	4
202	R:R:G67	R:R:Y65	10.14	No	Yes	0	2	3
203	R:R:Y65	R:R:Y71	31.77	Yes	No	14	3	3
204	R:R:D84	R:R:Y65	5.75	No	Yes	14	4	3
205	R:R:P86	R:R:Y65	8.34	No	Yes	0	2	3
206	R:R:G69	R:R:P70	4.06	No	No	0	1	1
207	R:R:A87	R:R:P70	3.74	No	No	0	4	1
208	R:R:D84	R:R:Y71	9.2	No	No	14	4	3
209	R:R:C112	R:R:C72	7.28	Yes	No	2	9	9
210	R:R:C72	R:R:W118	19.59	No	Yes	2	9	9
211	R:R:D84	R:R:R74	20.25	No	No	0	4	4
212	R:R:T75	R:R:W82	3.64	No	Yes	0	5	9
213	R:R:T75	R:R:W118	4.85	No	Yes	0	5	9
214	R:R:G78	R:R:W76	8.44	No	Yes	0	5	8
215	R:R:D77	R:R:W82	10.05	Yes	Yes	2	9	9
216	R:R:D77	R:R:S129	5.89	Yes	Yes	2	9	7
217	R:R:D77	R:R:Y131	5.75	Yes	Yes	2	9	5
218	R:R:W79	R:R:Y98	4.82	Yes	Yes	2	6	4
219	R:R:F99	R:R:W79	9.02	Yes	Yes	2	5	6
220	R:R:W79	R:R:Y131	15.43	Yes	Yes	2	6	5
221	R:R:L80	R:R:Q93	17.3	Yes	No	0	5	6
222	R:R:L80	R:R:P96	11.49	Yes	No	0	5	9
223	R:R:L80	R:R:V108	4.47	Yes	No	2	5	7
224	R:R:L80	R:R:Y131	7.03	Yes	Yes	2	5	5
225	R:R:S91	R:R:W82	3.71	No	Yes	0	5	9
226	R:R:Q93	R:R:W82	12.05	No	Yes	0	6	9
227	R:R:V108	R:R:W82	4.9	No	Yes	2	7	9
228	R:R:K110	R:R:W82	22.05	Yes	Yes	2	8	9
229	R:R:S129	R:R:W82	3.71	Yes	Yes	2	7	9
230	R:R:P86	R:R:T85	3.5	No	Yes	0	2	7
231	R:R:S91	R:R:T85	6.4	No	Yes	0	5	7
232	R:R:C112	R:R:T85	6.76	Yes	Yes	2	9	7
233	R:R:T85	R:R:W118	6.06	Yes	Yes	2	7	9
234	R:R:P86	R:R:V89	5.3	No	No	0	2	5
235	R:R:E114	R:R:G88	6.55	No	No	0	2	8
236	R:R:L90	R:R:T109	4.42	No	No	0	4	5
237	R:R:K107	R:R:Y92	5.97	No	No	0	3	4
238	R:R:T109	R:R:Y92	8.74	No	No	0	5	4
239	R:R:F94	R:R:K107	17.37	No	No	0	3	3
240	R:R:C95	R:R:P96	3.77	No	No	0	9	9
241	R:R:C95	R:R:F102	5.59	No	Yes	2	9	4
242	R:R:C134	R:R:C95	7.28	No	No	2	9	9
243	R:R:P96	R:R:Y98	12.52	No	Yes	0	9	4
244	R:R:F99	R:R:Y98	6.19	Yes	Yes	2	5	4
245	R:R:F102	R:R:F99	13.93	Yes	Yes	2	4	5
246	R:R:D101	R:R:F102	3.58	Yes	Yes	0	4	4
247	R:R:D101	R:R:N135	9.42	Yes	No	0	4	3
248	R:R:C134	R:R:F102	11.17	No	Yes	2	9	4
249	R:R:D103	R:R:P104	4.83	Yes	No	0	3	3
250	R:R:D103	R:R:S105	7.36	Yes	No	5	3	1
251	R:R:D103	R:R:E106	6.5	Yes	Yes	5	3	4
252	R:R:D103	R:R:K141	5.53	Yes	No	0	3	3
253	R:R:E294	R:R:P104	4.72	No	No	0	3	3
254	R:R:E106	R:R:S105	4.31	Yes	No	5	4	1
255	R:R:E106	R:R:M133	4.06	Yes	No	5	4	5
256	R:R:E106	R:R:F137	7	Yes	Yes	5	4	1
257	R:R:E106	R:R:K366	4.05	Yes	No	5	4	3
258	R:R:V108	R:R:Y131	13.88	No	Yes	2	7	5
259	R:R:N130	R:R:T109	4.39	Yes	No	0	8	5
260	R:R:K110	R:R:W118	23.21	Yes	Yes	2	8	9
261	R:R:K110	R:R:T127	3	Yes	No	0	8	4
262	R:R:K110	R:R:S129	6.12	Yes	Yes	2	8	7
263	R:R:D113	R:R:Y111	6.9	No	No	0	5	4
264	R:R:C112	R:R:W118	3.92	Yes	Yes	2	9	9
265	R:R:D113	R:R:V117	5.84	No	No	0	5	5
266	R:R:F119	R:R:W128	3.01	No	Yes	0	4	5
267	R:R:K120	R:R:T127	4.5	No	No	0	1	4
268	R:R:H121	R:R:P122	6.1	No	No	0	4	5
269	R:R:H121	R:R:W128	14.81	No	Yes	0	4	5
270	R:R:E123	R:R:N124	6.57	No	Yes	8	4	5
271	R:R:N124	R:R:R126	4.82	Yes	No	8	5	4
272	R:R:N130	R:R:W128	10.17	Yes	Yes	5	8	5
273	R:R:S129	R:R:Y131	8.9	Yes	Yes	2	7	5
274	R:R:N130	R:R:T132	7.31	Yes	No	0	8	6
275	R:R:F137	R:R:M133	3.73	Yes	No	5	1	5
276	R:R:N135	R:R:T138	2.92	No	No	0	3	2
277	R:R:A136	R:R:F137	8.32	No	Yes	0	2	1
278	R:R:F137	R:R:K366	9.93	Yes	No	5	1	3
279	R:R:P139	R:R:T138	3.5	No	No	0	3	2
280	R:R:E140	R:R:K143	4.05	No	No	0	2	1
281	R:R:L142	R:R:Y146	14.07	No	No	0	2	2
282	R:R:N144	R:R:Y374	8.14	No	No	0	4	6
283	R:R:V147	R:R:Y374	3.79	No	No	0	4	6
284	R:R:L148	R:R:Y374	3.52	No	No	0	5	6
285	R:R:H377	R:R:L148	9	Yes	No	15	7	5
286	R:R:Y149	R:R:Y150	2.98	Yes	No	0	5	4
287	R:R:I153	R:R:Y149	9.67	Yes	Yes	17	7	5
288	R:R:L202	R:R:Y149	11.72	No	Yes	17	7	5
289	R:R:L151	R:R:S378	6.01	No	No	0	5	5
290	R:R:F382	R:R:L151	3.65	No	No	0	7	5
291	R:R:A152	R:R:H381	7.32	No	Yes	0	7	9
292	R:R:I153	R:R:L202	4.28	Yes	No	17	7	7
293	R:R:G155	R:R:V154	3.68	No	No	0	8	6
294	R:R:F382	R:R:G155	9.03	No	No	0	7	8
295	R:R:H156	R:R:S195	9.76	Yes	No	0	7	7
296	R:R:H156	R:R:I198	17.23	Yes	No	0	7	7
297	R:R:H156	R:R:I199	3.98	Yes	No	0	7	7
298	R:R:H156	R:R:H381	10.75	Yes	Yes	0	7	9
299	R:R:F385	R:R:L158	14.61	Yes	No	0	5	4
300	R:R:G384	R:R:S159	3.71	No	No	0	9	9
301	R:R:I160	R:R:S195	4.64	No	No	0	5	7
302	R:R:I160	R:R:M196	4.37	No	No	0	5	4
303	R:R:F161	R:R:I165	7.54	No	No	0	4	5
304	R:R:F385	R:R:T162	7.78	Yes	No	0	5	6
305	R:R:A388	R:R:T162	3.36	No	No	0	8	6
306	R:R:F188	R:R:L163	6.09	Yes	Yes	0	8	8
307	R:R:L163	R:R:Y191	3.52	Yes	Yes	0	8	8
308	R:R:A388	R:R:L163	3.15	No	Yes	0	8	8
309	R:R:I192	R:R:V164	4.61	No	No	0	7	4
310	R:R:F393	R:R:I165	3.77	Yes	No	0	8	5
311	R:R:F188	R:R:S166	3.96	Yes	No	0	8	9
312	R:R:C392	R:R:S166	6.89	No	No	7	9	9
313	R:R:F393	R:R:S166	3.96	Yes	No	7	8	9
314	R:R:L167	R:R:V171	2.98	No	No	0	6	4
315	R:R:K185	R:R:L167	4.23	No	No	0	6	6
316	R:R:F173	R:R:I169	5.02	Yes	No	0	7	8
317	R:R:F170	R:R:V181	9.18	Yes	Yes	7	8	9
318	R:R:F170	R:R:K185	4.96	Yes	No	7	8	6
319	R:R:F170	R:R:F188	5.36	Yes	Yes	0	8	8
320	R:R:C392	R:R:F170	4.19	No	Yes	7	9	8
321	R:R:F172	R:R:F173	8.57	No	Yes	0	2	7
322	R:R:F173	R:R:L176	3.65	Yes	Yes	10	7	9
323	R:R:F173	R:R:T401	3.89	Yes	Yes	10	7	7
324	R:R:F173	R:R:Q405	7.03	Yes	Yes	0	7	4
325	R:R:L176	R:R:S175	3	Yes	No	10	9	8
326	R:R:S175	R:R:T401	3.2	No	Yes	10	8	7
327	R:R:E397	R:R:L176	3.98	No	Yes	10	9	9
328	R:R:L176	R:R:T401	5.9	Yes	Yes	10	9	7
329	R:R:G177	R:R:V181	3.68	No	Yes	0	7	9
330	R:R:C178	R:R:R180	5.57	No	No	0	8	9
331	R:R:C178	R:R:V181	3.42	No	Yes	0	8	9
332	R:R:Q179	R:R:Y243	7.89	No	Yes	0	7	8
333	R:R:K256	R:R:Q179	5.42	No	No	0	5	7
334	R:R:L259	R:R:Q179	13.31	Yes	No	0	5	7
335	R:R:H184	R:R:R180	7.9	No	No	0	9	9
336	R:R:K185	R:R:V181	3.04	No	Yes	7	6	9
337	R:R:L259	R:R:T182	2.95	Yes	No	0	5	5
338	R:R:L183	R:R:W236	3.42	No	Yes	0	8	9
339	R:R:E240	R:R:L183	3.98	No	No	0	9	8
340	R:R:L183	R:R:Y243	7.03	No	Yes	0	8	8
341	R:R:E240	R:R:H184	12.31	No	No	0	9	9
342	R:R:H184	R:R:Y391	4.36	No	No	0	9	8
343	R:R:N186	R:R:W236	15.82	No	Yes	4	9	9
344	R:R:N186	R:R:Y263	8.14	No	No	4	9	5
345	R:R:N186	R:R:W267	5.65	No	Yes	4	9	9
346	R:R:M187	R:R:T190	6.02	Yes	Yes	4	8	9
347	R:R:M187	R:R:Y191	8.38	Yes	Yes	4	8	8
348	R:R:M187	R:R:M237	7.22	Yes	Yes	4	8	9
349	R:R:E240	R:R:M187	5.41	No	Yes	0	9	8
350	R:R:F188	R:R:V387	3.93	Yes	No	0	8	9
351	R:R:L189	R:R:L193	5.54	No	No	0	3	6
352	R:R:N233	R:R:T190	7.31	No	Yes	0	9	9
353	R:R:T190	R:R:W236	6.06	Yes	Yes	4	9	9
354	R:R:T190	R:R:W267	6.06	Yes	Yes	4	9	9
355	R:R:N233	R:R:Y191	15.12	No	Yes	0	9	8
356	R:R:M237	R:R:Y191	4.79	Yes	Yes	4	9	8
357	R:R:Q383	R:R:Y191	10.15	Yes	Yes	4	9	8
358	R:R:G384	R:R:Y191	4.35	No	Yes	0	9	8
359	R:R:V387	R:R:Y191	3.79	No	Yes	0	9	8
360	R:R:L193	R:R:M229	8.48	No	No	0	6	4
361	R:R:I198	R:R:N194	7.08	No	No	0	7	8
362	R:R:H226	R:R:I197	5.3	Yes	No	0	6	5
363	R:R:I197	R:R:M229	2.92	No	No	0	5	4
364	R:R:H226	R:R:I198	3.98	Yes	No	0	6	7
365	R:R:H201	R:R:V205	8.3	Yes	No	0	6	7
366	R:R:H201	R:R:H226	3.58	Yes	Yes	0	6	6
367	R:R:P207	R:R:V206	5.3	No	No	0	3	3
368	R:R:L211	R:R:N208	6.87	No	No	0	1	3
369	R:R:E210	R:R:R214	11.63	No	No	0	3	4
370	R:R:L211	R:R:R214	6.07	No	No	20	1	4
371	R:R:L211	R:R:P216	4.93	No	Yes	20	1	4
372	R:R:N288	R:R:V212	2.96	No	No	0	4	3
373	R:R:P216	R:R:R214	4.32	Yes	No	20	4	4
374	R:R:D215	R:R:K220	5.53	No	No	0	6	7
375	R:R:D215	R:R:N288	14.81	No	No	0	6	4
376	R:R:P216	R:R:S218	5.34	Yes	No	0	4	3
377	R:R:C219	R:R:P216	7.53	No	Yes	0	9	4
378	R:R:I221	R:R:V217	3.07	No	No	0	4	3
379	R:R:C219	R:R:C289	7.28	No	No	0	9	9
380	R:R:K220	R:R:N286	5.6	No	No	3	7	7
381	R:R:K220	R:R:W290	19.73	No	Yes	3	7	9
382	R:R:F225	R:R:I221	3.77	No	No	0	5	4
383	R:R:H223	R:R:Q227	17.31	No	No	0	5	7
384	R:R:H223	R:R:W290	3.17	No	Yes	0	5	9
385	R:R:F224	R:R:T274	9.08	No	No	0	5	6
386	R:R:H277	R:R:Q227	3.71	Yes	No	3	7	7
387	R:R:I301	R:R:Q227	5.49	No	No	3	7	7
388	R:R:C232	R:R:Y228	9.41	No	No	0	8	8
389	R:R:L271	R:R:Y228	8.21	No	No	0	4	8
390	R:R:T274	R:R:Y228	3.75	No	No	0	6	8
391	R:R:M230	R:R:Y234	3.59	No	Yes	0	6	7
392	R:R:A231	R:R:P270	3.74	No	Yes	0	5	9
393	R:R:C232	R:R:W267	3.92	No	Yes	0	8	9
394	R:R:C232	R:R:P270	3.77	No	Yes	0	8	9
395	R:R:M237	R:R:Y234	3.59	Yes	Yes	4	9	7
396	R:R:V305	R:R:Y234	15.14	No	Yes	0	7	7
397	R:R:F356	R:R:Y234	10.32	Yes	Yes	4	7	7
398	R:R:F235	R:R:L265	3.65	Yes	Yes	6	5	7
399	R:R:F235	R:R:F269	7.5	Yes	Yes	6	5	3
400	R:R:F235	R:R:P270	8.67	Yes	Yes	6	5	9
401	R:R:C239	R:R:W236	3.92	No	Yes	0	7	9
402	R:R:W236	R:R:Y263	3.86	Yes	No	4	9	5
403	R:R:G266	R:R:W236	8.44	No	Yes	0	9	9
404	R:R:W236	R:R:W267	16.87	Yes	Yes	4	9	9
405	R:R:M237	R:R:Q383	6.8	Yes	Yes	4	9	9
406	R:R:I242	R:R:L238	7.14	Yes	Yes	0	7	8
407	R:R:A308	R:R:L238	6.3	No	Yes	0	7	8
408	R:R:L238	R:R:V311	2.98	Yes	No	0	8	6
409	R:R:L238	R:R:N312	4.12	Yes	No	0	8	9
410	R:R:C239	R:R:L265	4.76	No	Yes	0	7	7
411	R:R:G241	R:R:N312	5.09	No	No	0	8	9
412	R:R:I242	R:R:Y262	4.84	Yes	Yes	0	7	7
413	R:R:F315	R:R:I242	5.02	No	Yes	0	8	7
414	R:R:L247	R:R:Y243	11.72	No	Yes	0	8	8
415	R:R:Q257	R:R:Y243	6.76	Yes	Yes	9	5	8
416	R:R:Y243	R:R:Y262	6.95	Yes	Yes	9	8	7
417	R:R:I248	R:R:L244	4.28	No	No	0	7	9
418	R:R:I319	R:R:L244	4.28	No	No	0	9	9
419	R:R:H245	R:R:V249	12.45	No	Yes	21	8	6
420	R:R:F315	R:R:H245	27.15	No	No	0	8	8
421	R:R:H245	R:R:N318	7.65	No	No	21	8	8
422	R:R:T246	R:R:V250	4.76	No	No	0	7	5
423	R:R:Q257	R:R:T246	7.09	Yes	No	9	5	7
424	R:R:I248	R:R:V249	3.07	No	Yes	0	7	6
425	R:R:V249	R:R:V250	3.21	Yes	No	0	6	5
426	R:R:N318	R:R:V249	2.96	No	Yes	21	8	6
427	R:R:A251	R:R:T254	5.03	No	No	0	6	6
428	R:R:Q257	R:R:T254	4.25	Yes	No	0	5	6
429	R:R:Q257	R:R:Y262	4.51	Yes	Yes	9	5	7
430	R:R:R258	R:R:R260	15.99	No	No	13	5	3
431	R:R:R258	R:R:W261	9	No	Yes	13	5	2
432	R:R:L259	R:R:Y262	3.52	Yes	Yes	0	5	7
433	R:R:L259	R:R:Y263	5.86	Yes	No	0	5	5
434	R:R:R260	R:R:W261	8	No	Yes	13	3	2
435	R:R:F269	R:R:L265	3.65	Yes	Yes	6	3	7
436	R:R:F269	R:R:P270	4.33	Yes	Yes	6	3	9
437	R:R:P273	R:R:V272	3.53	No	No	0	6	4
438	R:R:I276	R:R:V272	3.07	No	No	0	5	4
439	R:R:I279	R:R:T275	3.04	No	No	0	3	3
440	R:R:I276	R:R:I300	2.94	No	No	0	5	8
441	R:R:H277	R:R:R281	12.41	Yes	Yes	3	7	7
442	R:R:H277	R:R:L298	5.14	Yes	No	0	7	6
443	R:R:H277	R:R:I301	10.61	Yes	No	3	7	7
444	R:R:L297	R:R:T280	11.79	Yes	No	3	4	4
445	R:R:I300	R:R:T280	4.56	No	No	3	8	4
446	R:R:F285	R:R:R281	7.48	Yes	Yes	3	6	7
447	R:R:D287	R:R:R281	5.96	Yes	Yes	3	3	7
448	R:R:R281	R:R:W290	13.99	Yes	Yes	3	7	9
449	R:R:R281	R:R:T295	6.47	Yes	Yes	3	7	4
450	R:R:L297	R:R:R281	3.64	Yes	Yes	3	4	7
451	R:R:V283	R:R:Y284	12.62	No	No	0	3	2
452	R:R:D287	R:R:F285	7.17	Yes	Yes	3	3	6
453	R:R:F285	R:R:S292	3.96	Yes	No	3	6	4
454	R:R:F285	R:R:T295	15.56	Yes	Yes	3	6	4
455	R:R:N286	R:R:W290	9.04	No	Yes	3	7	9
456	R:R:D287	R:R:W290	5.58	Yes	Yes	3	3	9
457	R:R:D287	R:R:S292	5.89	Yes	No	3	3	4
458	R:R:C289	R:R:L291	4.76	No	No	0	9	6
459	R:R:L298	R:R:V293	2.98	No	No	0	6	6
460	R:R:L297	R:R:T295	5.9	Yes	Yes	3	4	4
461	R:R:W361	R:R:Y299	3.86	No	Yes	0	4	7
462	R:R:G303	R:R:P304	4.06	No	Yes	6	4	9
463	R:R:L309	R:R:V305	2.98	No	No	0	7	7
464	R:R:F356	R:R:L309	3.65	Yes	No	0	7	7
465	R:R:V310	R:R:V357	3.21	No	No	0	4	7
466	R:R:F315	R:R:V311	5.24	No	No	0	8	6
467	R:R:L352	R:R:N312	8.24	No	No	0	9	9
468	R:R:F313	R:R:L317	10.96	No	No	0	6	5
469	R:R:F313	R:R:I354	5.02	No	Yes	0	6	6
470	R:R:F313	R:R:V357	3.93	No	No	0	6	7
471	R:R:L316	R:R:V320	2.98	No	No	0	9	7
472	R:R:L316	R:R:L348	4.15	No	No	0	9	9
473	R:R:I354	R:R:L316	7.14	Yes	No	0	6	9
474	R:R:N318	R:R:R321	7.23	No	No	0	8	8
475	R:R:T345	R:R:V320	3.17	No	No	0	9	7
476	R:R:R321	R:R:V322	5.23	No	No	0	8	8
477	R:R:R328	R:R:V324	5.23	No	No	0	6	5
478	R:R:E329	R:R:T325	4.23	No	No	0	6	7
479	R:R:M327	R:R:M337	7.22	No	No	0	7	7
480	R:R:K340	R:R:M327	5.76	No	No	0	8	7
481	R:R:M337	R:R:R328	3.72	No	No	0	7	6
482	R:R:E332	R:R:T330	5.64	No	No	0	5	5
483	R:R:E332	R:R:H336	12.31	No	No	0	5	6
484	R:R:E334	R:R:Y338	4.49	No	No	0	6	7
485	R:R:H336	R:R:K340	11.79	No	No	0	6	8
486	R:R:I347	R:R:I390	2.94	No	No	0	8	8
487	R:R:P350	R:R:V349	3.53	No	No	0	9	8
488	R:R:I354	R:R:V349	9.22	Yes	No	0	6	8
489	R:R:L351	R:R:L352	4.15	No	No	0	9	9
490	R:R:L351	R:R:Y391	17.58	No	No	0	9	8
491	R:R:I354	R:R:L352	4.28	Yes	No	0	6	9
492	R:R:G353	R:R:Q355	4.93	No	Yes	4	9	8
493	R:R:F356	R:R:G353	3.01	Yes	No	4	7	9
494	R:R:F356	R:R:Q355	9.37	Yes	Yes	4	7	8
495	R:R:L379	R:R:Q355	3.99	No	Yes	0	5	8
496	R:R:Q355	R:R:Q383	7.68	Yes	Yes	4	8	9
497	R:R:F356	R:R:I380	5.02	Yes	No	0	7	6
498	R:R:F356	R:R:Q383	4.68	Yes	Yes	4	7	9
499	R:R:F359	R:R:V358	11.8	No	No	0	6	5
500	R:R:F359	R:R:Y372	4.13	No	Yes	11	6	7
501	R:R:F359	R:R:M376	4.98	No	No	11	6	7
502	R:R:P363	R:R:R362	2.88	No	Yes	11	7	4
503	R:R:G369	R:R:R362	7.51	No	Yes	0	4	4
504	R:R:R362	R:R:Y372	7.2	Yes	Yes	11	4	7
505	R:R:D373	R:R:R362	14.29	No	Yes	0	5	4
506	R:R:L368	R:R:P363	4.93	No	No	0	3	7
507	R:R:P363	R:R:Y372	6.95	No	Yes	11	7	7
508	R:R:L368	R:R:N365	8.24	No	No	0	3	4
509	R:R:I371	R:R:M367	2.92	No	No	0	5	4
510	R:R:M376	R:R:Y372	11.97	No	Yes	11	7	7
511	R:R:L379	R:R:V375	2.98	No	No	0	5	4
512	R:R:I380	R:R:M376	2.92	No	No	0	6	7
513	R:R:H377	R:R:H381	9.55	Yes	Yes	0	7	9
514	R:R:F382	R:R:F386	4.29	No	No	0	7	5
515	R:R:F385	R:R:F386	5.36	Yes	No	0	5	5
516	R:R:F385	R:R:T389	3.89	Yes	No	0	5	5
517	R:R:F393	R:R:T389	3.89	Yes	No	0	8	5
518	R:R:I390	R:R:Y391	7.25	No	No	0	8	8
519	R:R:C392	R:R:F393	4.19	No	Yes	7	9	8
520	R:R:E397	R:R:N395	3.94	No	No	0	9	9
521	R:R:N395	R:R:V398	8.87	No	No	0	9	9
522	R:R:N396	R:R:T400	2.92	No	No	0	6	4
523	R:R:E397	R:R:T401	4.23	No	Yes	10	9	7
524	R:R:F409	R:R:Q405	3.51	No	Yes	0	3	4
525	R:R:I192	R:R:L163	2.85	No	Yes	0	7	8
526	E:E:L94	R:R:M59	2.83	No	Yes	0	7	5
527	E:E:E145	E:E:T144	2.82	No	No	0	8	7
528	R:R:K370	R:R:N144	2.8	No	No	0	4	4
529	E:E:C57	E:E:F101	2.79	No	Yes	0	9	9
530	E:E:A34	E:E:R37	2.77	No	Yes	0	2	3
531	L:L:A8	L:L:R11	2.77	No	No	0	0	0
532	L:L:F15	R:R:A145	2.77	Yes	No	0	0	4
533	R:R:H201	R:R:V206	2.77	Yes	No	0	6	3
534	R:R:A278	R:R:F224	2.77	No	No	0	6	5
535	R:R:A51	R:R:Y98	2.67	No	Yes	0	8	4
536	E:E:V129	R:R:F269	2.62	No	Yes	0	7	3
537	L:L:V32	R:R:F102	2.62	No	Yes	0	0	4
538	R:R:F170	R:R:V398	2.62	Yes	No	0	8	9
539	R:R:F173	R:R:V402	2.62	Yes	No	0	7	5
540	R:R:F314	R:R:V310	2.62	No	No	0	5	4
541	E:E:D47	E:E:E68	2.6	No	No	0	5	4
542	R:R:F224	R:R:T275	2.59	No	No	0	5	3
543	R:R:A282	R:R:W290	2.59	No	Yes	0	3	9
544	R:R:R321	R:R:T325	2.59	No	No	0	8	7
545	R:R:R404	R:R:T400	2.59	No	No	0	7	4
546	E:E:I63	E:E:R64	2.51	No	No	0	5	5
547	R:R:D113	R:R:F119	2.39	No	No	0	5	4
548	E:E:D47	E:E:R61	2.38	No	No	0	5	4
549	E:E:L119	E:E:Y120	2.34	No	No	0	8	5
550	R:R:E210	R:R:R213	2.33	No	No	0	3	2
551	R:R:L264	R:R:W261	2.28	No	Yes	0	3	2
552	E:E:E53	E:E:W56	2.18	No	No	0	4	5
553	R:R:G116	R:R:P70	2.03	No	No	0	9	1
554	R:R:G268	R:R:P270	2.03	No	Yes	0	6	9
555	R:R:C72	R:R:G116	1.96	No	No	2	9	9
556	R:R:C112	R:R:G116	1.96	Yes	No	2	9	9
557	E:E:P114	E:E:P115	1.95	Yes	No	0	9	9
558	E:E:P126	R:R:P304	1.95	No	Yes	0	9	9
559	L:L:P28	L:L:P29	1.95	No	No	0	0	0
560	E:E:G108	E:E:S107	1.86	No	No	0	6	6
561	E:E:G52	E:E:V51	1.84	No	No	0	5	5
562	R:R:G44	R:R:V43	1.84	No	No	0	4	2
563	R:R:G209	R:R:V212	1.84	No	No	0	3	3
564	L:L:G33	L:L:T36	1.82	No	Yes	0	0	0
565	E:E:G108	E:E:I106	1.76	No	No	0	6	3
566	E:E:G81	E:E:L80	1.71	No	No	0	1	6
567	R:R:G168	R:R:L167	1.71	No	No	0	1	6
568	L:L:N22	R:R:G209	1.7	No	No	0	0	3
569	R:R:A341	R:R:V324	1.7	No	No	0	9	5
570	R:R:C394	R:R:T389	1.69	No	No	0	5	5
571	R:R:M306	R:R:P360	1.68	No	No	0	4	5
572	R:R:E68	R:R:G69	1.64	No	No	0	1	1
573	E:E:C40	E:E:M76	1.62	No	Yes	0	9	4
574	E:E:I127	R:R:A307	1.62	No	No	0	8	3
575	R:R:D101	R:R:P100	1.61	Yes	No	0	4	4
576	R:R:V320	R:R:V324	1.6	No	No	0	7	5
577	E:E:T42	E:E:V46	1.59	No	No	0	2	1
578	E:E:T62	E:E:V51	1.59	No	No	0	8	5
579	E:E:T128	E:E:V124	1.59	No	No	0	5	6
580	E:E:L131	R:R:A307	1.58	No	No	0	8	3
581	R:R:A344	R:R:L323	1.58	No	No	0	9	9
582	R:R:I153	R:R:S157	1.55	Yes	No	0	7	7
583	R:R:I199	R:R:S157	1.55	No	No	0	7	7
584	R:R:I153	R:R:V203	1.54	Yes	No	0	7	3
585	R:R:I199	R:R:V203	1.54	No	No	0	7	3
586	R:R:I371	R:R:V375	1.54	No	No	0	5	4
587	E:E:K142	E:E:S141	1.53	No	Yes	0	9	9
588	R:R:M346	R:R:V342	1.52	No	No	0	8	8
589	L:L:T6	R:R:M306	1.51	Yes	No	0	0	4
590	R:R:M346	R:R:T345	1.51	No	No	0	8	9
591	R:R:L222	R:R:V205	1.49	No	No	0	6	7
592	E:E:N86	E:E:V89	1.48	No	Yes	0	9	8
593	E:E:L132	E:E:T128	1.47	No	No	0	6	5
594	R:R:A333	R:R:H336	1.46	No	No	0	5	6
595	E:E:G33	E:E:Y32	1.45	No	Yes	0	5	5
596	R:R:G88	R:R:Y111	1.45	No	No	0	8	4
597	R:R:I347	R:R:K343	1.45	No	No	0	8	8
598	R:R:E204	R:R:V203	1.43	No	No	0	4	3
599	E:E:P121	E:E:Y120	1.39	No	No	0	7	5
600	E:E:A110	E:E:R112	1.38	No	No	0	4	4
601	L:L:L27	L:L:N21	1.37	No	No	0	0	0
602	R:R:E329	R:R:K326	1.35	No	No	0	6	9
603	R:R:E334	R:R:M337	1.35	No	No	0	6	7
604	R:R:E140	R:R:N144	1.31	No	No	0	2	4
605	R:R:R404	R:R:T401	1.29	No	Yes	0	7	7
606	R:R:Q405	R:R:Q408	1.28	Yes	No	0	4	7
607	R:R:Q405	R:R:W406	1.1	Yes	No	0	4	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	E:E:Y32	8.836	5	1	5
2	E:E:R37	12.2971	7	1	3
3	E:E:W59	6.7275	4	0	7
4	E:E:Y66	5.69833	6	1	9
5	E:E:W74	7.6125	4	12	6
6	E:E:M76	10.365	4	1	4
7	E:E:W84	5.56	4	0	7
8	E:E:V89	5.512	5	1	8
9	E:E:F92	10.542	5	1	5
10	E:E:F93	8.11833	6	1	9
11	E:E:H97	7.146	5	1	9
12	E:E:Y100	10.5883	6	1	8
13	E:E:F101	6.29	4	1	9
14	E:E:D113	6.1275	4	3	9
15	E:E:P114	5.38833	6	3	9
16	E:E:S141	4.0575	4	9	9
17	L:L:T6	5.412	5	4	0
18	L:L:F15	8.55	4	0	0
19	L:L:T36	3.1575	4	19	0
20	L:L:P37	7.0025	4	0	0
21	L:L:?38	6.1175	4	2	0
22	R:R:Q52	8.4175	4	1	6
23	R:R:Y53	6.3725	4	1	1
24	R:R:Y56	8.425	6	1	3
25	R:R:M59	4.5	4	1	5
26	R:R:Y65	14	4	14	3
27	R:R:W76	10.2125	4	1	8
28	R:R:D77	7.9425	4	2	9
29	R:R:W79	10.298	5	2	6
30	R:R:L80	10.0725	4	2	5
31	R:R:W82	8.58714	7	2	9
32	R:R:T85	5.68	4	2	7
33	R:R:Y98	7.35833	6	2	4
34	R:R:F99	10.8525	4	2	5
35	R:R:D101	5.82	4	0	4
36	R:R:F102	7.378	5	2	4
37	R:R:D103	6.055	4	5	3
38	R:R:E106	5.184	5	5	4
39	R:R:K110	13.595	4	2	8
40	R:R:C112	4.98	4	2	9
41	R:R:W118	11.526	5	2	9
42	R:R:N124	5.9175	4	8	5
43	R:R:W128	8.53	4	5	5
44	R:R:S129	6.41	5	2	7
45	R:R:N130	11.6275	4	5	8
46	R:R:Y131	8.98167	6	2	5
47	R:R:F137	7.245	4	5	1
48	R:R:Y149	6.9725	4	17	5
49	R:R:I153	4.26	4	17	7
50	R:R:H156	10.43	4	0	7
51	R:R:L163	3.9025	4	0	8
52	R:R:F170	5.262	5	7	8
53	R:R:F173	5.13	6	10	7
54	R:R:L176	4.1325	4	10	9
55	R:R:V181	4.83	4	7	9
56	R:R:M187	6.7575	4	4	8
57	R:R:F188	4.835	4	0	8
58	R:R:T190	6.3625	4	4	9
59	R:R:Y191	7.15714	7	4	8
60	R:R:H201	4.395	4	0	6
61	R:R:P216	5.53	4	20	4
62	R:R:H226	4.1425	4	0	6
63	R:R:Y234	8.276	5	4	7
64	R:R:F235	5.9275	4	6	5
65	R:R:W236	8.34143	7	4	9
66	R:R:M237	5.6	4	4	9
67	R:R:L238	4.992	5	0	8
68	R:R:I242	4.936	5	0	7
69	R:R:Y243	8.07	5	9	8
70	R:R:V249	5.4225	4	21	6
71	R:R:Q257	5.1	5	9	5
72	R:R:L259	6.41	4	0	5
73	R:R:W261	9.7475	4	13	2
74	R:R:Y262	4.728	5	9	7
75	R:R:L265	4.505	4	6	7
76	R:R:W267	8.125	4	4	9
77	R:R:F269	5.62167	6	6	3
78	R:R:P270	4.508	5	6	9
79	R:R:H277	7.9675	4	3	7
80	R:R:R281	8.325	6	3	7
81	R:R:F285	8.00167	6	3	6
82	R:R:D287	6.15	4	3	3
83	R:R:W290	9.01667	6	3	9
84	R:R:T295	9.15	4	3	4
85	R:R:L297	6.1525	4	3	4
86	R:R:Y299	3.5975	4	0	7
87	R:R:H302	6.0025	4	4	6
88	R:R:P304	4.0975	4	6	9
89	R:R:I354	6.415	4	0	6
90	R:R:Q355	6.4925	4	4	8
91	R:R:F356	5.68625	8	4	7
92	R:R:R362	7.97	4	11	4
93	R:R:Y372	7.5625	4	11	7
94	R:R:H377	7.2975	4	15	7
95	R:R:H381	8.6175	4	0	9
96	R:R:Q383	7.3275	4	4	9
97	R:R:F385	7.91	4	0	5
98	R:R:F393	3.9525	4	7	8
99	R:R:T401	3.702	5	10	7
100	R:R:Q405	3.23	4	0	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	E:E:F101	E:E:H97	14.5692	7.92	Yes	Yes	1	9	9
2	E:E:H97	R:R:Y56	24.988	6.53	Yes	Yes	1	9	3
3	E:E:W59	R:R:Y53	10.8209	6.75	Yes	Yes	0	7	1
4	E:E:R37	E:E:V89	13.7801	15.69	Yes	Yes	1	3	8
5	L:L:P37	R:R:R126	97.6968	2.88	Yes	No	0	0	4
6	L:L:?38	L:L:P37	85.9778	4.06	Yes	Yes	0	0	0
7	L:L:?38	R:R:D77	38.0197	10.08	Yes	Yes	2	0	9
8	R:R:D77	R:R:W82	39.8937	10.05	Yes	Yes	2	9	9
9	R:R:T75	R:R:W82	73.7189	3.64	No	Yes	0	5	9
10	E:E:D90	R:R:T75	74.2631	2.89	No	No	0	8	5
11	E:E:D90	E:E:V89	29.8132	2.92	No	Yes	0	8	8
12	L:L:?38	R:R:S129	46.6885	7.43	Yes	Yes	2	0	7
13	R:R:S129	R:R:W82	39.8787	3.71	Yes	Yes	2	7	9
14	R:R:N124	R:R:R126	97.6414	4.82	Yes	No	8	5	4
15	R:R:P86	R:R:T85	13.3193	3.5	No	Yes	0	2	7
16	R:R:P86	R:R:Y65	11.3703	8.34	No	Yes	0	2	3
17	L:L:S34	R:R:N124	97.8553	7.45	No	Yes	8	0	5
18	L:L:S34	R:R:H121	98.2373	8.37	No	No	0	0	4
19	R:R:H121	R:R:W128	98.4484	14.81	No	Yes	0	4	5
20	H:H:?502	R:R:W128	97.9525	6.13	No	Yes	5	0	5
21	H:H:?502	R:R:M133	99.9123	5.07	No	No	5	0	5
22	R:R:E106	R:R:M133	99.4731	4.06	Yes	No	5	4	5
23	R:R:D103	R:R:E106	100	6.5	Yes	Yes	5	3	4
24	R:R:D103	R:R:P104	93.6964	4.83	Yes	No	0	3	3
25	R:R:E294	R:R:P104	95.9002	4.72	No	No	0	3	3
26	L:L:K1	R:R:E294	95.9237	10.8	No	No	0	0	3
27	L:L:K1	R:R:H296	22.5975	5.24	No	No	0	0	2
28	E:E:D113	R:R:H296	22.2325	5.04	Yes	No	0	9	2
29	L:L:?0	R:R:Y299	79.2389	3.15	No	Yes	0	0	7
30	L:L:?0	L:L:K1	80.4987	5.05	No	No	0	0	0
31	E:E:T130	R:R:P304	11.36	6.99	No	Yes	6	9	9
32	R:R:T190	R:R:W236	11.0578	6.06	Yes	Yes	4	9	9
33	R:R:M187	R:R:T190	20.4552	6.02	Yes	Yes	4	8	9
34	R:R:M187	R:R:M237	37.9658	7.22	Yes	Yes	4	8	9
35	R:R:M237	R:R:Y234	62.1783	3.59	Yes	Yes	4	9	7
36	L:L:T6	R:R:Y234	61.4698	8.74	Yes	Yes	4	0	7
37	L:L:T4	L:L:T6	82.5274	4.71	No	Yes	4	0	0
38	L:L:T4	R:R:Y299	86.4128	3.75	No	Yes	0	0	7
39	R:R:C232	R:R:W267	12.3077	3.92	No	Yes	0	8	9
40	R:R:T190	R:R:W267	12.7155	6.06	Yes	Yes	4	9	9
41	R:R:E240	R:R:M187	24.2341	5.41	No	Yes	0	9	8
42	R:R:E240	R:R:L183	14.3403	3.98	No	No	0	9	8
43	R:R:L183	R:R:Y243	13.8533	7.03	No	Yes	0	8	8
44	L:L:C2	R:R:H302	12.7371	4.42	No	Yes	4	0	6
45	L:L:C2	R:R:L298	12.3969	4.76	No	No	0	0	6
46	R:R:H277	R:R:R281	12.007	12.41	Yes	Yes	3	7	7
47	R:R:H277	R:R:L298	11.6246	5.14	Yes	No	0	7	6
48	L:L:N3	R:R:W361	10.2105	15.82	No	No	0	0	4
49	R:R:D103	R:R:K141	11.2718	5.53	Yes	No	0	3	3
50	L:L:F15	R:R:K141	10.8786	19.85	Yes	No	0	0	3
51	L:L:T6	R:R:F356	30.4879	3.89	Yes	Yes	4	0	7
52	R:R:L298	R:R:V293	11.0151	2.98	No	No	0	6	6
53	L:L:E14	R:R:V293	10.2372	5.7	No	No	0	0	6
54	R:R:F99	R:R:W79	13.2091	9.02	Yes	Yes	2	5	6
55	R:R:S91	R:R:W82	10.1331	3.71	No	Yes	0	5	9
56	R:R:M237	R:R:Y191	25.5586	4.79	Yes	Yes	4	9	8
57	R:R:L163	R:R:Y191	33.1458	3.52	Yes	Yes	0	8	8
58	R:R:F356	R:R:Q383	28.8382	4.68	Yes	Yes	4	7	9
59	R:R:Q383	R:R:Y191	28.5961	10.15	Yes	Yes	4	9	8
60	R:R:F188	R:R:L163	24.3058	6.09	Yes	Yes	0	8	8
61	R:R:V387	R:R:Y191	24.7896	3.79	No	Yes	0	9	8
62	R:R:F188	R:R:V387	24.219	3.93	Yes	No	0	8	9
63	R:R:F170	R:R:F188	39.1838	5.36	Yes	Yes	0	8	8
64	R:R:F170	R:R:V398	31.4605	2.62	Yes	No	0	8	9
65	R:R:N395	R:R:V398	30.2622	8.87	No	No	0	9	9
66	R:R:E397	R:R:N395	29.0629	3.94	No	No	0	9	9
67	R:R:E397	R:R:L176	12.114	3.98	No	Yes	10	9	9
68	R:R:E397	R:R:T401	15.7483	4.23	No	Yes	10	9	7
69	R:R:E240	R:R:H184	11.8723	12.31	No	No	0	9	9
70	R:R:H184	R:R:Y391	10.9645	4.36	No	No	0	9	8
71	E:E:D90	R:R:Y56	44.4481	6.9	No	Yes	0	8	3
72	E:E:F101	E:E:Y100	12.0112	4.13	Yes	Yes	1	9	8
73	L:L:P37	R:R:W79	11.1817	17.57	Yes	Yes	0	0	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
E:E:F83	R:R:N124	4.83	8	No	Yes	5	5	2	1
E:E:F83	R:R:R126	20.31	8	No	No	5	4	2	1
E:E:D113	R:R:H296	5.04	3	Yes	No	9	2	2	1
E:E:I123	R:R:Y299	3.63	0	No	Yes	9	7	2	1
L:L:?0	R:R:Y299	3.15	0	No	Yes	0	7	0	1
L:L:K1	R:R:E294	10.8	0	No	No	0	3	0	1
L:L:K1	R:R:H296	5.24	0	No	No	0	2	0	1
L:L:C2	R:R:L298	4.76	4	No	No	0	6	0	1
L:L:C2	R:R:H302	4.42	4	No	Yes	0	6	0	1
L:L:N3	R:R:W361	15.82	0	No	No	0	4	0	1
L:L:T4	R:R:Y299	3.75	4	No	Yes	0	7	0	1
L:L:T4	R:R:H302	5.48	4	No	Yes	0	6	0	1
L:L:A5	R:R:F356	5.55	0	No	Yes	0	7	0	1
L:L:T6	R:R:Y234	8.74	4	Yes	Yes	0	7	0	1
L:L:T6	R:R:H302	8.21	4	Yes	Yes	0	6	0	1
L:L:T6	R:R:F356	3.89	4	Yes	Yes	0	7	0	1
L:L:C7	R:R:H302	5.9	4	No	Yes	0	6	0	1
L:L:A8	R:R:H377	2.93	0	No	Yes	0	7	0	1
L:L:T9	R:R:H381	6.85	0	No	Yes	0	9	0	1
L:L:Q10	R:R:H226	3.71	0	No	Yes	0	6	0	1
L:L:L12	R:R:L148	4.15	15	No	No	0	5	0	1
L:L:L12	R:R:H377	7.71	15	No	Yes	0	7	0	1
L:L:A13	R:R:H201	2.93	0	No	Yes	0	6	0	1
L:L:E14	R:R:L291	3.98	16	No	No	0	6	0	1
L:L:E14	R:R:V293	5.7	16	No	No	0	6	0	1
L:L:F15	R:R:K141	19.85	0	Yes	No	0	3	0	1
L:L:F15	R:R:L142	3.65	0	Yes	No	0	2	0	1
L:L:L16	R:R:A145	3.15	0	No	No	0	4	0	1
L:L:L16	R:R:Y149	3.52	0	No	Yes	0	5	0	1
L:L:R17	R:R:V212	5.23	16	No	No	0	3	0	1
L:L:R17	R:R:L291	8.5	16	No	No	0	6	0	1
L:L:H18	R:R:P104	3.05	0	No	No	0	3	0	1
L:L:S20	R:R:Y146	5.09	18	No	No	0	2	0	1
L:L:F23	R:R:Y146	7.22	18	No	No	0	2	0	1
L:L:F23	R:R:P207	5.78	18	No	No	0	3	0	1
L:L:P29	R:R:N135	4.89	0	No	No	0	3	0	1
L:L:T30	R:R:F99	14.27	0	No	Yes	0	5	0	1
L:L:T30	R:R:D101	8.67	0	No	Yes	0	4	0	1
L:L:S34	R:R:H121	8.37	8	No	No	0	4	0	1
L:L:S34	R:R:E123	8.62	8	No	No	0	4	0	1
L:L:S34	R:R:N124	7.45	8	No	Yes	0	5	0	1
L:L:P37	R:R:W79	17.57	0	Yes	Yes	0	6	0	1
L:L:P37	R:R:R126	2.88	0	Yes	No	0	4	0	1
L:L:?38	R:R:D77	10.08	2	Yes	Yes	0	9	0	1
L:L:?38	R:R:S129	7.43	2	Yes	Yes	0	7	0	1
L:L:?38	R:R:Y131	2.9	2	Yes	Yes	0	5	0	1
L:L:?101	R:R:W361	7.37	0	No	No	0	4	0	1
R:R:M48	R:R:W79	4.65	2	No	Yes	6	6	2	1
R:R:M48	R:R:Y98	10.78	2	No	Yes	6	4	2	2
R:R:D77	R:R:W82	10.05	2	Yes	Yes	9	9	1	2
R:R:D77	R:R:S129	5.89	2	Yes	Yes	9	7	1	1
R:R:D77	R:R:Y131	5.75	2	Yes	Yes	9	5	1	1
R:R:W79	R:R:Y98	4.82	2	Yes	Yes	6	4	1	2
R:R:F99	R:R:W79	9.02	2	Yes	Yes	5	6	1	1
R:R:W79	R:R:Y131	15.43	2	Yes	Yes	6	5	1	1
R:R:L80	R:R:V108	4.47	2	Yes	No	5	7	2	2
R:R:L80	R:R:Y131	7.03	2	Yes	Yes	5	5	2	1
R:R:V108	R:R:W82	4.9	2	No	Yes	7	9	2	2
R:R:K110	R:R:W82	22.05	2	Yes	Yes	8	9	2	2
R:R:S129	R:R:W82	3.71	2	Yes	Yes	7	9	1	2
R:R:C95	R:R:F102	5.59	2	No	Yes	9	4	2	1
R:R:C134	R:R:C95	7.28	2	No	No	9	9	2	2
R:R:F99	R:R:Y98	6.19	2	Yes	Yes	5	4	1	2
R:R:F102	R:R:F99	13.93	2	Yes	Yes	4	5	1	1
R:R:D101	R:R:F102	3.58	0	Yes	Yes	4	4	1	1
R:R:D101	R:R:N135	9.42	0	Yes	No	4	3	1	1
R:R:C134	R:R:F102	11.17	2	No	Yes	9	4	2	1
R:R:D103	R:R:P104	4.83	5	Yes	No	3	3	2	1
R:R:D103	R:R:K141	5.53	5	Yes	No	3	3	2	1
R:R:E294	R:R:P104	4.72	0	No	No	3	3	1	1
R:R:V108	R:R:Y131	13.88	2	No	Yes	7	5	2	1
R:R:K110	R:R:S129	6.12	2	Yes	Yes	8	7	2	1
R:R:H121	R:R:P122	6.1	0	No	No	4	5	1	2
R:R:H121	R:R:W128	14.81	0	No	Yes	4	5	1	2
R:R:E123	R:R:N124	6.57	8	No	Yes	4	5	1	1
R:R:N124	R:R:R126	4.82	8	Yes	No	5	4	1	1
R:R:S129	R:R:Y131	8.9	2	Yes	Yes	7	5	1	1
R:R:N135	R:R:T138	2.92	0	No	No	3	2	1	2
R:R:L142	R:R:Y146	14.07	0	No	No	2	2	1	1
R:R:L148	R:R:Y374	3.52	15	No	No	5	6	1	2
R:R:H377	R:R:L148	9	15	Yes	No	7	5	1	1
R:R:Y149	R:R:Y150	2.98	17	Yes	No	5	4	1	2
R:R:I153	R:R:Y149	9.67	17	Yes	Yes	7	5	2	1
R:R:L202	R:R:Y149	11.72	17	No	Yes	7	5	2	1
R:R:A152	R:R:H381	7.32	0	No	Yes	7	9	2	1
R:R:I153	R:R:L202	4.28	17	Yes	No	7	7	2	2
R:R:H156	R:R:I198	17.23	0	Yes	No	7	7	2	2
R:R:H156	R:R:H381	10.75	0	Yes	Yes	7	9	2	1
R:R:H226	R:R:I197	5.3	0	Yes	No	6	5	1	2
R:R:H226	R:R:I198	3.98	0	Yes	No	6	7	1	2
R:R:H201	R:R:V205	8.3	0	Yes	No	6	7	1	2
R:R:H201	R:R:H226	3.58	0	Yes	Yes	6	6	1	1
R:R:P207	R:R:V206	5.3	0	No	No	3	3	1	2
R:R:N288	R:R:V212	2.96	0	No	No	4	3	2	1
R:R:M230	R:R:Y234	3.59	0	No	Yes	6	7	2	1
R:R:M237	R:R:Y234	3.59	4	Yes	Yes	9	7	2	1
R:R:V305	R:R:Y234	15.14	0	No	Yes	7	7	2	1
R:R:F356	R:R:Y234	10.32	4	Yes	Yes	7	7	1	1
R:R:M237	R:R:Q383	6.8	4	Yes	Yes	9	9	2	2
R:R:H277	R:R:L298	5.14	3	Yes	No	7	6	2	1
R:R:C289	R:R:L291	4.76	0	No	No	9	6	2	1
R:R:L298	R:R:V293	2.98	0	No	No	6	6	1	1
R:R:W361	R:R:Y299	3.86	0	No	Yes	4	7	1	1
R:R:L309	R:R:V305	2.98	0	No	No	7	7	2	2
R:R:F356	R:R:L309	3.65	4	Yes	No	7	7	1	2
R:R:G353	R:R:Q355	4.93	4	No	Yes	9	8	2	2
R:R:F356	R:R:G353	3.01	4	Yes	No	7	9	1	2
R:R:F356	R:R:Q355	9.37	4	Yes	Yes	7	8	1	2
R:R:Q355	R:R:Q383	7.68	4	Yes	Yes	8	9	2	2
R:R:F356	R:R:I380	5.02	4	Yes	No	7	6	1	2
R:R:F356	R:R:Q383	4.68	4	Yes	Yes	7	9	1	2
R:R:H377	R:R:H381	9.55	15	Yes	Yes	7	9	1	1
L:L:F15	R:R:A145	2.77	0	Yes	No	0	4	0	1
R:R:H201	R:R:V206	2.77	0	Yes	No	6	3	1	2
L:L:V32	R:R:F102	2.62	0	No	Yes	0	4	0	1
R:R:G209	R:R:V212	1.84	0	No	No	3	3	1	1
L:L:N22	R:R:G209	1.7	0	No	No	0	3	0	1
R:R:M306	R:R:P360	1.68	0	No	No	4	5	1	2
R:R:D101	R:R:P100	1.61	0	Yes	No	4	4	1	2
L:L:T6	R:R:M306	1.51	4	Yes	No	0	4	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9BP3_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.88
Number of Linked Nodes	498
Number of Links	607
Number of Hubs	100
Number of Links mediated by Hubs	349
Number of Communities	21
Number of Nodes involved in Communities	156
Number of Links involved in Communities	217

Path Summary
Number Of Nodes in MetaPath	74
Number Of Links MetaPath	73
Number of Shortest Paths	368201
Length Of Smallest Path	3
Average Path Length	24.6268
Length of Longest Path	50
Minimum Path Strength	1.19
Average Path Strength	6.30182
Maximum Path Strength	22.81
Minimum Path Correlation	0.7
Average Path Correlation	0.966539
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	2.5641
Average % Of Corr. Nodes	49.0831
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	49.7329
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• calcitonin family binding • calcitonin gene-related peptide binding • binding • peptide hormone binding • hormone binding • molecular transducer activity • coreceptor activity • signaling receptor activity • calcitonin family receptor activity • peptide receptor activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • transmembrane signaling receptor activity • calcitonin gene-related peptide receptor activity • amylin receptor activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • cellular localization • establishment of protein localization
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • cellular localization • establishment of protein localization • transport • intracellular transport • establishment of localization • localization • protein transport • establishment of localization in cell • macromolecule localization • intracellular protein localization • intracellular protein transport • regulation of signaling • regulation of signal transduction • regulation of response to stimulus • regulation of cell communication • regulation of G protein-coupled receptor signaling pathway • import into cell • receptor internalization • receptor-mediated endocytosis • endocytosis • vesicle-mediated transport • developmental process • multicellular organismal process • blood vessel morphogenesis • tube development • angiogenesis • vasculature development • circulatory system development • anatomical structure morphogenesis • multicellular organism development • tube morphogenesis • anatomical structure formation involved in morphogenesis • anatomical structure development • blood vessel development • system development • calcitonin family receptor signaling pathway • calcitonin gene-related peptide receptor signaling pathway • amylin receptor signaling pathway • positive regulation of glycoprotein metabolic process • positive regulation of protein metabolic process • positive regulation of biological process • carbohydrate derivative metabolic process • positive regulation of macromolecule biosynthetic process • regulation of primary metabolic process • positive regulation of metabolic process • positive regulation of biosynthetic process • positive regulation of macromolecule metabolic process • protein metabolic process • positive regulation of cellular process • regulation of glycoprotein biosynthetic process • positive regulation of glycoprotein biosynthetic process • carbohydrate derivative biosynthetic process • regulation of biosynthetic process • regulation of protein metabolic process • glycoprotein biosynthetic process • primary metabolic process • regulation of macromolecule metabolic process • glycoprotein metabolic process • macromolecule biosynthetic process • regulation of glycoprotein metabolic process • biosynthetic process • metabolic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • regulation of metabolic process • monoatomic ion transport • monoatomic cation transport • calcium ion transport • metal ion transport • protein localization to cell periphery • protein localization to plasma membrane • localization within membrane • protein localization to membrane • amylin receptor 1 signaling pathway • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to endogenous stimulus • response to chemical • cellular response to hormone stimulus • protein-containing complex • receptor complex • cell surface • cellular anatomical structure • cell periphery • plasma membrane • membrane • plasma membrane protein complex • membrane protein complex • plasma membrane signaling receptor complex • G protein-coupled receptor complex • CGRP receptor complex • calcitonin family receptor complex • protein binding • binding • signaling receptor binding • amyloid-beta binding • peptide binding • molecular function activator activity • molecular function regulator activity • signaling receptor regulator activity • receptor ligand activity • signaling receptor activator activity • hormone activity • lipid binding • identical protein binding • positive regulation of cell communication • positive regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • regulation of intracellular signal transduction • intracellular signaling cassette • regulation of calcium-mediated signaling • positive regulation of calcium-mediated signaling • positive regulation of intracellular signal transduction • calcium-mediated signaling • positive regulation of signaling • apoptotic process • cell death • programmed cell death • positive regulation of programmed cell death • regulation of apoptotic process • regulation of programmed cell death • positive regulation of apoptotic process • behavior • eating behavior • feeding behavior • cell-cell signaling • regulation of cellular component organization • negative regulation of cellular component organization • protein-containing complex organization • negative regulation of biological process • regulation of cellular component biogenesis • negative regulation of protein-containing complex assembly • cellular component organization • cellular component biogenesis • regulation of protein-containing complex assembly • cellular component assembly • protein-containing complex assembly • negative regulation of cellular process • cellular component organization or biogenesis • myeloid leukocyte differentiation • regulation of leukocyte differentiation • cellular developmental process • regulation of developmental process • cell development • regulation of cell differentiation • regulation of cell development • regulation of osteoclast differentiation • cell differentiation • osteoclast differentiation • regulation of immune system process • regulation of multicellular organismal process • negative regulation of cell differentiation • negative regulation of hemopoiesis • regulation of multicellular organismal development • negative regulation of leukocyte differentiation • hemopoiesis • regulation of myeloid cell differentiation • negative regulation of developmental process • regulation of myeloid leukocyte differentiation • negative regulation of myeloid cell differentiation • negative regulation of osteoclast differentiation • negative regulation of myeloid leukocyte differentiation • negative regulation of cell development • myeloid cell differentiation • negative regulation of immune system process • immune system process • regulation of hemopoiesis • negative regulation of multicellular organismal process • leukocyte differentiation • positive regulation of MAPK cascade • regulation of MAPK cascade • MAPK cascade • negative regulation of tissue remodeling • homeostatic process • negative regulation of bone remodeling • regulation of bone remodeling • tissue homeostasis • regulation of tissue remodeling • regulation of bone resorption • bone resorption • negative regulation of bone resorption • multicellular organismal-level homeostasis • tissue remodeling • bone remodeling • anatomical structure homeostasis • amylin receptor 2 signaling pathway • system process • sensory perception • nervous system process • sensory perception of pain • positive regulation of cAMP/PKA signal transduction • cAMP/PKA signal transduction • regulation of cAMP/PKA signal transduction • negative regulation of amyloid fibril formation • regulation of amyloid fibril formation • amyloid fibril formation • negative regulation of supramolecular fiber organization • negative regulation of protein metabolic process • negative regulation of macromolecule metabolic process • negative regulation of metabolic process • regulation of supramolecular fiber organization • supramolecular fiber organization • amylin receptor 3 signaling pathway • extracellular region • somatodendritic compartment • cell body • neuronal cell body • extracellular space • calcitonin family receptor activity • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • calcitonin receptor activity • amylin receptor activity • calcitonin gene-related peptide receptor activity • calcitonin binding • calcitonin family binding • peptide hormone binding • hormone binding • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • catabolic process • RNA metabolic process • macromolecule catabolic process • nucleobase-containing compound metabolic process • post-transcriptional regulation of gene expression • regulation of RNA metabolic process • regulation of mRNA catabolic process • regulation of nucleobase-containing compound metabolic process • RNA catabolic process • mRNA catabolic process • regulation of catabolic process • gene expression • mRNA metabolic process • nucleic acid metabolic process • nucleobase-containing compound catabolic process • regulation of mRNA stability • regulation of gene expression • negative regulation of gene expression • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • regulation of RNA stability • nucleic acid catabolic process • regulation of mRNA metabolic process • positive regulation of ERK1 and ERK2 cascade • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of gene expression • regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • phosphatidylinositol 3-kinase/protein kinase B signal transduction • response to corticosteroid • response to lipid • response to steroid hormone • response to glucocorticoid • response to oxygen-containing compound • response to nitrogen compound • response to amyloid-beta • cell surface receptor signaling pathway • ossification • regulation of ossification • negative regulation of ossification • membrane-bounded organelle • cell projection • organelle • cilium • plasma membrane bounded cell projection • amylin receptor complex • amylin receptor complex 3 • amylin receptor complex 2 • amylin receptor complex 1 • axon • neuron projection • acrosomal vesicle • intracellular anatomical structure • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle • secretory granule • secretory vesicle • cytoplasm • vesicle • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • skin development • skin epidermis development • hair follicle development • molting cycle • ectodermal placode development • hair cycle process • cellular homeostasis • chemical homeostasis • glucose homeostasis • carbohydrate homeostasis • intracellular chemical homeostasis • intracellular glucose homeostasis • neuromuscular process • regulation of system process • skeletal muscle contraction • muscle contraction • muscle system process • regulation of muscle system process • striated muscle contraction • multicellular organismal movement • musculoskeletal movement • regulation of striated muscle contraction • regulation of muscle contraction • regulation of skeletal muscle contraction • sensory perception of chemical stimulus • sensory perception of smell • cellular response to nitrogen compound • response to peptide hormone • cellular response to peptide hormone stimulus • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • skeletal system development • bone development • response to pH • cellular response to pH • response to abiotic stimulus • cellular response to acidic pH • response to acidic pH • cellular response to abiotic stimulus • cellular response to environmental stimulus • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • adaptive thermogenesis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • regulation of localization • nitrogen compound transport • positive regulation of establishment of protein localization • positive regulation of insulin secretion involved in cellular response to glucose stimulus • positive regulation of insulin secretion • regulation of peptide hormone secretion • regulation of hormone levels • positive regulation of peptide hormone secretion • establishment of protein localization to extracellular region • protein secretion • regulation of protein secretion • regulation of secretion • cellular response to carbohydrate stimulus • response to glucose • positive regulation of protein localization • insulin secretion involved in cellular response to glucose stimulus • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • positive regulation of secretion by cell • hormone secretion • protein localization to extracellular region • positive regulation of protein transport • peptide secretion • regulation of secretion by cell • secretion by cell • positive regulation of hormone secretion • response to monosaccharide • response to carbohydrate • positive regulation of secretion • signal release • cellular response to hexose stimulus • cellular response to monosaccharide stimulus • positive regulation of peptide secretion • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cellular response to glucose stimulus • regulation of protein transport • positive regulation of protein secretion • peptide transport • response to hexose • positive regulation of transport • regulation of cellular localization • regulation of insulin secretion • peptide hormone secretion • regulation of insulin secretion involved in cellular response to glucose stimulus • hormone transport • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • cellular response to catecholamine stimulus • serotonin receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-activating serotonin receptor signaling pathway • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • inflammatory response to antigenic stimulus • regulation of response to stress • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • adenylate cyclase-activating dopamine receptor signaling pathway • G protein-coupled dopamine receptor signaling pathway • bile acid signaling pathway • adenylate cyclase-activating G protein-coupled bile acid receptor signaling pathway • renal system process • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • extrinsic component of plasma membrane • catalytic complex • cytoplasmic side of membrane • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular membrane-bounded organelle • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • trans-Golgi network • organelle membrane • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of taste • sensory organ development • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • cell population proliferation • small GTPase-mediated signal transduction • Ras protein signal transduction • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• RAMP1-like • G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• RAMP1-like • G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	NAG
PDB Residues	H:H:?501 H:H:?502 H:H:?503
Environment Details	Open EMBL-EBI Page
Code	NAG
Name	N-Acetylglucosamine
Synonyms	N-Acetylchitosamine
Identifier
Formula	C8 H15 N O6
Molecular Weight	221.208
SMILES
PubChem	24139
Formal Charge	0
Total Atoms	30
Total Chiral Atoms	5
Total Bonds	30
Total Aromatic Bonds	0


Code	GGL
PDB Residues	L:L:?0
Environment Details	Open EMBL-EBI Page
Code	GGL
Name	Glutamic acid
Synonyms	Glutamic acid
Identifier
Formula	C5 H9 N O4
Molecular Weight	147.129
SMILES
PubChem	33032
Formal Charge	0
Total Atoms	19
Total Chiral Atoms	1
Total Bonds	18
Total Aromatic Bonds	0


Code	NH2
PDB Residues	L:L:?38
Environment Details	Open EMBL-EBI Page
Code	NH2
Name	AMINO GROUP
Synonyms
Identifier
Formula	H2 N
Molecular Weight	16.023
SMILES
PubChem	123329
Formal Charge	0
Total Atoms	3
Total Chiral Atoms	0
Total Bonds	2
Total Aromatic Bonds	0


Code	_L_
PDB Residues	L:L:?101
Environment Details	Open EMBL-EBI Page
Code	_L_
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds


PDBsum	Open PDBsum Page
Chain	E
Protein	RAMP1
UniProt	O60894
Sequence	>9BP3_nogp_Chain_E Y G A L L R E L C L T Q F Q V D M E A V G E T L W C D W G R T I R S Y R E L A D C T W H M A E K L G C F W P N A E V D R F F L A V H G R Y F R S C P I S G R A V R D P P G S I L Y P F I V V P I T V T L L V T A L V V W Q S K R T E Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	L
Protein	Cagrilintide
UniProt	P10997
Sequence	>9BP3_nogp_Chain_L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	R
Protein	Receptor
UniProt	P30988
Sequence	>9BP3_nogp_Chain_R Y V V G R K K M M D A Q Y K C Y D R M Q Q L P A Y Q G E G P Y C N R T W D G W L C W D D T P A G V L S Y Q F C P D Y F P D F D P S E K V T K Y C D E K G V W F K H P E N N R T W S N Y T M C N A F T P E K L K N A Y V L Y Y L A I V G H S L S I F T L V I S L G I F V F F R S L G C Q R V T L H K N M F L T Y I L N S M I I I I H L V E V V P N G E L V R R D P V S C K I L H F F H Q Y M M A C N Y F W M L C E G I Y L H T L I V V A V F T E K Q R L R W Y Y L L G W G F P L V P T T I H A I T R A V Y F N D N C W L S V E T H L L Y I I H G P V M A A L V V N F F F L L N I V R V L V T K M R E T H E A E S H M Y L K A V K A T M I L V P L L G I Q F V V F P W R P S N K M L G K I Y D Y V M H S L I H F Q G F F V A T I Y C F C N N E V Q T T V K R Q W A Q F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7TYF	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Amylin	-	Gs/β1/γ2; RAMP1	2.2	2022-03-23	doi.org/10.1126/science.abm9609
	7TYF (No Gprot)	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Amylin	-		2.2	2022-03-23	doi.org/10.1126/science.abm9609
	7TYW	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Calcitonin-1	-	Gs/β1/γ2; RAMP1	3	2022-03-23	doi.org/10.1126/science.abm9609
	7TYW (No Gprot)	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Calcitonin-1	-		3	2022-03-23	doi.org/10.1126/science.abm9609
	9AUC	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Calcitonin gene-related peptide-1	-	Gs/β1/γ2; RAMP1	2.4	2024-04-24	doi.org/10.1021/acs.biochem.4c00114
	9AUC (No Gprot)	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Calcitonin gene-related peptide-1	-		2.4	2024-04-24	doi.org/10.1021/acs.biochem.4c00114
	9BLW	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Cagrilintide (non-acylated)	-	Gs/β1/γ2; RAMP1	3.2	2025-04-16	doi.org/10.1038/s41467-025-58680-y
	9BLW (No Gprot)	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Cagrilintide (non-acylated)	-		3.2	2025-04-16	doi.org/10.1038/s41467-025-58680-y
	9BP3	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Cagrilintide	-	Gs/β1/γ2; RAMP1	2.2	2025-04-23	doi.org/10.1038/s41467-025-58680-y
	9BP3 (No Gprot)	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Cagrilintide	-		2.2	2025-04-23	doi.org/10.1038/s41467-025-58680-y

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