psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	E:E:C27	E:E:E29	3.04	No	No	0	8	5
2	E:E:C27	E:E:L80	4.76	No	No	14	8	6
3	E:E:C27	E:E:C82	7.28	No	No	14	8	8
4	E:E:A30	E:E:Q28	3.03	No	No	0	4	4
5	E:E:E29	E:E:N86	5.26	No	Yes	0	5	9
6	E:E:L35	E:E:N31	5.49	Yes	No	0	2	2
7	E:E:A77	E:E:Y32	4	No	Yes	0	8	5
8	E:E:N86	E:E:Y32	12.79	Yes	Yes	1	9	5
9	E:E:E88	E:E:Y32	3.37	Yes	Yes	1	4	5
10	E:E:V89	E:E:Y32	3.79	No	Yes	1	8	5
11	E:E:E88	E:E:G33	6.55	Yes	No	0	4	5
12	E:E:L35	E:E:L39	4.15	Yes	No	15	2	1
13	E:E:K79	E:E:L35	2.82	No	Yes	0	2	2
14	E:E:L36	E:E:T73	2.95	No	No	0	5	9
15	E:E:F92	E:E:L36	8.53	Yes	No	0	5	5
16	E:E:L41	E:E:R37	4.86	No	No	0	5	3
17	E:E:L39	E:E:M76	4.24	No	No	0	1	4
18	E:E:C40	E:E:C72	7.28	No	No	0	9	9
19	E:E:L41	E:E:Q45	3.99	No	No	0	5	4
20	E:E:F92	E:E:L41	7.31	Yes	No	0	5	5
21	E:E:Q45	E:E:T42	2.83	No	No	0	4	2
22	E:E:Q43	E:E:V46	4.3	No	No	1	1	1
23	E:E:D47	E:E:Q43	6.53	Yes	No	1	5	1
24	E:E:F44	E:E:M48	3.73	Yes	Yes	1	9	9
25	E:E:F44	E:E:L69	14.61	Yes	No	0	9	8
26	E:E:F44	E:E:V96	3.93	Yes	No	0	9	8
27	E:E:F44	E:E:Y100	3.09	Yes	Yes	1	9	8
28	E:E:D47	E:E:V46	4.38	Yes	No	1	5	1
29	E:E:D47	E:E:R64	3.57	Yes	No	1	5	5
30	E:E:D47	E:E:S65	5.89	Yes	No	1	5	4
31	E:E:M48	E:E:W56	12.8	Yes	Yes	1	9	5
32	E:E:M48	E:E:T62	3.01	Yes	No	1	9	8
33	E:E:M48	E:E:Y100	13.17	Yes	Yes	1	9	8
34	E:E:F101	E:E:M48	4.98	Yes	Yes	1	9	9
35	E:E:E53	E:E:W56	6.54	No	Yes	0	4	5
36	E:E:W56	E:E:Y100	14.47	Yes	Yes	1	5	8
37	E:E:C104	E:E:C57	7.28	No	No	0	9	9
38	E:E:D58	E:E:G60	3.35	No	No	0	5	4
39	E:E:T62	E:E:W59	3.64	No	Yes	1	8	7
40	E:E:I63	E:E:W59	10.57	No	Yes	1	5	7
41	E:E:W59	R:R:D50	4.47	Yes	No	1	7	2
42	E:E:W59	R:R:Y53	19.29	Yes	Yes	1	7	1
43	E:E:F101	E:E:T62	5.19	Yes	No	1	9	8
44	E:E:I63	R:R:M49	4.37	No	Yes	1	5	4
45	E:E:I63	R:R:D50	2.8	No	No	1	5	2
46	E:E:R64	E:E:S65	6.59	No	No	1	5	4
47	E:E:E68	E:E:R64	3.49	No	No	0	4	5
48	E:E:F93	E:E:Y66	10.32	Yes	Yes	1	9	9
49	E:E:H97	E:E:Y66	6.53	Yes	Yes	1	9	9
50	E:E:F101	E:E:Y66	4.13	Yes	Yes	1	9	9
51	E:E:Y66	R:R:Y53	5.96	Yes	Yes	1	9	1
52	E:E:R67	R:R:R45	3.2	No	Yes	1	5	7
53	E:E:R67	R:R:K46	3.71	No	No	0	5	4
54	E:E:R67	R:R:M49	3.72	No	Yes	1	5	4
55	E:E:F92	E:E:L69	7.31	Yes	No	0	5	8
56	E:E:F93	E:E:L69	4.87	Yes	No	0	9	8
57	E:E:A70	R:R:M49	3.22	No	Yes	1	8	4
58	E:E:A70	R:R:Q52	3.03	No	Yes	1	8	6
59	E:E:D71	E:E:H75	8.82	No	No	0	3	2
60	E:E:D71	R:R:R45	4.76	No	Yes	0	3	7
61	E:E:T73	E:E:W84	8.49	No	Yes	1	9	7
62	E:E:T73	E:E:V89	7.93	No	No	1	9	8
63	E:E:H75	E:E:W74	12.7	No	No	0	2	6
64	E:E:E78	E:E:W74	22.9	No	No	0	4	6
65	E:E:W74	E:E:W84	5.62	No	Yes	0	6	7
66	E:E:K79	E:E:L80	4.23	No	No	0	2	6
67	E:E:C82	E:E:L80	3.17	No	No	14	8	6
68	E:E:F83	R:R:N124	9.67	No	No	0	5	5
69	E:E:F83	R:R:R126	23.52	No	No	0	5	4
70	E:E:P85	E:E:W84	18.92	No	Yes	0	9	7
71	E:E:V89	E:E:W84	6.13	No	Yes	1	8	7
72	E:E:W84	L:L:?37	3.69	Yes	Yes	1	7	0
73	E:E:W84	R:R:Q52	4.38	Yes	Yes	1	7	6
74	E:E:P85	R:R:W76	4.05	No	Yes	0	9	8
75	E:E:P85	R:R:G78	4.06	No	No	0	9	5
76	E:E:E88	E:E:N86	3.94	Yes	Yes	1	4	9
77	E:E:E88	E:E:R91	10.47	Yes	No	0	4	3
78	E:E:D90	R:R:Y56	8.05	No	Yes	1	8	3
79	E:E:D90	R:R:T75	2.89	No	No	0	8	5
80	E:E:D90	R:R:W76	4.47	No	Yes	1	8	8
81	E:E:F92	E:E:V96	5.24	Yes	No	0	5	8
82	E:E:F93	R:R:Q52	9.37	Yes	Yes	1	9	6
83	E:E:F93	R:R:Y56	15.47	Yes	Yes	1	9	3
84	E:E:L94	R:R:Y56	3.52	No	Yes	1	7	3
85	E:E:L94	R:R:M59	4.24	No	Yes	1	7	5
86	E:E:H97	R:R:Y53	7.62	Yes	Yes	1	9	1
87	E:E:H97	R:R:Y56	10.89	Yes	Yes	1	9	3
88	E:E:H97	R:R:D57	13.87	Yes	No	1	9	4
89	E:E:H97	R:R:Q60	6.18	Yes	No	1	9	3
90	E:E:G98	E:E:R102	6	No	No	0	5	5
91	E:E:R99	E:E:Y100	10.29	No	Yes	0	4	8
92	E:E:F101	E:E:Y100	4.13	Yes	Yes	1	9	8
93	E:E:F101	R:R:Y53	14.44	Yes	Yes	1	9	1
94	E:E:S103	R:R:Q61	4.33	No	No	0	7	3
95	E:E:R109	E:E:R112	8.53	No	No	0	6	4
96	E:E:P115	E:E:R109	2.88	No	No	0	9	6
97	E:E:R109	R:R:Y284	7.2	No	No	0	6	2
98	E:E:V111	R:R:F285	9.18	No	Yes	0	5	6
99	E:E:D113	E:E:P114	3.22	Yes	Yes	0	9	9
100	E:E:D113	R:R:F285	5.97	Yes	Yes	2	9	6
101	E:E:D113	R:R:T295	8.67	Yes	Yes	2	9	4
102	E:E:D113	R:R:H296	3.78	Yes	No	0	9	2
103	E:E:L119	E:E:P114	3.28	No	Yes	0	8	9
104	E:E:P114	R:R:Y284	15.3	Yes	No	0	9	2
105	E:E:P114	R:R:L297	4.93	Yes	Yes	0	9	4
106	E:E:G116	E:E:Y120	5.79	No	No	0	5	5
107	E:E:L119	R:R:H296	3.86	No	No	0	8	2
108	E:E:F122	R:R:T280	3.89	No	No	0	9	4
109	E:E:P126	E:E:V125	3.53	No	No	0	9	6
110	E:E:P126	R:R:I300	3.39	No	Yes	0	9	8
111	E:E:I127	R:R:G303	3.53	No	No	6	8	4
112	E:E:I127	R:R:P304	6.77	No	No	6	8	9
113	E:E:T130	R:R:F235	3.89	No	Yes	6	9	5
114	E:E:T130	R:R:F269	6.49	No	Yes	6	9	3
115	E:E:T130	R:R:P304	6.99	No	No	6	9	9
116	E:E:V133	R:R:F269	11.8	No	Yes	0	8	3
117	E:E:T134	R:R:L238	7.37	No	Yes	0	8	8
118	E:E:V137	R:R:I242	4.61	No	Yes	0	9	7
119	E:E:V137	R:R:L265	7.45	No	Yes	0	9	7
120	E:E:V138	R:R:I242	6.14	No	Yes	0	9	7
121	E:E:Q140	E:E:W139	10.95	Yes	No	0	8	6
122	E:E:Q140	E:E:R143	5.84	Yes	No	11	8	7
123	E:E:Q140	R:R:R258	10.51	Yes	Yes	11	8	5
124	E:E:Q140	R:R:W261	16.43	Yes	Yes	11	8	2
125	E:E:S141	R:R:T246	7.99	No	No	0	9	7
126	E:E:K142	R:R:V250	4.55	No	No	0	9	5
127	E:E:R143	R:R:R258	10.66	No	Yes	11	7	5
128	L:L:A1	R:R:E294	4.53	No	No	0	0	3
129	L:L:C2	L:L:T4	3.38	Yes	Yes	2	0	0
130	L:L:C2	L:L:C7	7.28	Yes	No	2	0	0
131	L:L:C2	R:R:L298	4.76	Yes	No	0	0	6
132	L:L:C2	R:R:H302	4.42	Yes	Yes	2	0	6
133	L:L:D3	R:R:W361	10.05	No	No	0	0	4
134	L:L:T4	L:L:T6	4.71	Yes	Yes	2	0	0
135	L:L:C7	L:L:T4	3.38	No	Yes	2	0	0
136	L:L:T4	R:R:M306	4.52	Yes	No	2	0	4
137	L:L:A5	R:R:F356	4.16	No	Yes	0	0	7
138	L:L:T6	R:R:Y234	8.74	Yes	Yes	0	0	7
139	L:L:T6	R:R:H302	9.58	Yes	Yes	2	0	6
140	L:L:T6	R:R:M306	6.02	Yes	No	2	0	4
141	L:L:C7	R:R:H302	10.32	No	Yes	2	0	6
142	L:L:R11	L:L:V8	3.92	No	No	0	0	0
143	L:L:V8	R:R:H377	6.92	No	Yes	0	0	7
144	L:L:V8	R:R:I380	4.61	No	No	0	0	6
145	L:L:T9	R:R:I198	3.04	No	Yes	0	0	7
146	L:L:H10	R:R:H226	7.17	No	No	0	0	6
147	L:L:H10	R:R:M230	6.57	No	Yes	2	0	6
148	L:L:H10	R:R:H302	8.36	No	Yes	2	0	6
149	L:L:R11	R:R:V293	3.92	No	No	0	0	6
150	L:L:L12	L:L:L16	4.15	No	No	0	0	0
151	L:L:L12	R:R:L148	2.77	No	Yes	7	0	5
152	L:L:L12	R:R:H377	6.43	No	Yes	7	0	7
153	L:L:A13	R:R:H201	2.93	No	Yes	0	0	6
154	L:L:L15	L:L:S19	3	No	No	16	0	0
155	L:L:L15	R:R:K141	4.23	No	No	0	0	3
156	L:L:L15	R:R:L142	4.15	No	Yes	16	0	2
157	L:L:L16	R:R:A145	3.15	No	No	0	0	4
158	L:L:L16	R:R:Y149	3.52	No	Yes	0	0	5
159	L:L:S17	R:R:L291	4.5	No	Yes	0	0	6
160	L:L:R18	R:R:P104	5.76	No	No	0	0	3
161	L:L:S19	R:R:L142	6.01	No	Yes	16	0	2
162	L:L:G21	L:L:K24	3.49	No	No	0	0	0
163	L:L:F27	L:L:V22	5.24	No	No	0	0	0
164	L:L:V23	R:R:L142	4.47	No	Yes	0	0	2
165	L:L:V23	R:R:Y146	10.09	No	No	0	0	2
166	L:L:?101	L:L:K24	12.36	Yes	No	0	0	0
167	L:L:F27	R:R:D101	4.78	No	Yes	0	0	4
168	L:L:P29	L:L:V28	3.53	No	No	0	0	0
169	L:L:T30	R:R:F99	20.75	Yes	Yes	1	0	5
170	L:L:T30	R:R:D101	8.67	Yes	Yes	1	0	4
171	L:L:T30	R:R:F102	5.19	Yes	Yes	1	0	4
172	L:L:T30	R:R:N135	2.92	Yes	No	1	0	3
173	L:L:S34	R:R:H121	6.97	No	No	0	0	4
174	L:L:S34	R:R:E123	10.06	No	No	0	0	4
175	L:L:K35	R:R:N124	4.2	No	No	0	0	5
176	L:L:?37	L:L:A36	3.83	Yes	No	0	0	0
177	L:L:?37	R:R:D77	3.3	Yes	Yes	1	0	9
178	L:L:?37	R:R:G78	8.32	Yes	No	1	0	5
179	L:L:?37	R:R:W79	9.23	Yes	Yes	1	0	6
180	L:L:?37	R:R:R126	7.87	Yes	No	0	0	4
181	L:L:?37	R:R:W128	6.46	Yes	No	0	0	5
182	L:L:?37	R:R:S129	6.08	Yes	Yes	1	0	7
183	L:L:?37	R:R:Y131	3.8	Yes	Yes	1	0	5
184	L:L:?101	R:R:Y146	11.3	Yes	No	8	0	2
185	L:L:?101	R:R:Y150	10.28	Yes	No	8	0	4
186	L:L:?101	R:R:L151	3.64	Yes	No	0	0	5
187	L:L:?101	R:R:V154	3.92	Yes	No	0	0	6
188	R:R:G44	R:R:K47	5.23	No	No	0	4	4
189	R:R:M49	R:R:R45	4.96	Yes	Yes	1	4	7
190	R:R:D97	R:R:K47	6.91	No	No	0	2	4
191	R:R:M48	R:R:W79	5.82	No	Yes	1	6	6
192	R:R:M48	R:R:Y98	9.58	No	Yes	1	6	4
193	R:R:M49	R:R:Q52	5.44	Yes	Yes	1	4	6
194	R:R:Q52	R:R:Y56	5.64	Yes	Yes	1	6	3
195	R:R:Q52	R:R:W76	12.05	Yes	Yes	1	6	8
196	R:R:D57	R:R:Y53	13.79	No	Yes	1	4	1
197	R:R:C55	R:R:M59	3.24	No	Yes	1	9	5
198	R:R:C55	R:R:W76	10.45	No	Yes	1	9	8
199	R:R:C55	R:R:C81	7.28	No	No	1	9	9
200	R:R:M59	R:R:Y56	3.59	Yes	Yes	1	5	3
201	R:R:W76	R:R:Y56	8.68	Yes	Yes	1	8	3
202	R:R:D57	R:R:Q60	5.22	No	No	1	4	3
203	R:R:L62	R:R:R58	3.64	No	No	0	3	3
204	R:R:D83	R:R:R58	5.96	No	No	0	5	3
205	R:R:M59	R:R:R74	9.93	Yes	No	0	5	4
206	R:R:L62	R:R:P63	6.57	No	No	0	3	1
207	R:R:E68	R:R:Y65	5.61	No	Yes	4	1	3
208	R:R:Y65	R:R:Y71	17.87	Yes	No	4	3	3
209	R:R:D84	R:R:Y65	4.6	No	Yes	4	4	3
210	R:R:P86	R:R:Y65	5.56	Yes	Yes	4	2	3
211	R:R:E68	R:R:P86	6.29	No	Yes	4	1	2
212	R:R:G69	R:R:P70	4.06	No	No	0	1	1
213	R:R:D84	R:R:Y71	8.05	No	No	4	4	3
214	R:R:C72	R:R:T85	3.38	No	Yes	4	9	7
215	R:R:C112	R:R:C72	5.46	No	No	4	9	9
216	R:R:C72	R:R:W118	5.22	No	Yes	4	9	9
217	R:R:N73	R:R:R74	3.62	No	No	0	4	4
218	R:R:D84	R:R:R74	19.06	No	No	0	4	4
219	R:R:T75	R:R:W118	12.13	No	Yes	0	5	9
220	R:R:C81	R:R:W76	3.92	No	Yes	1	9	8
221	R:R:D77	R:R:G78	3.35	Yes	No	1	9	5
222	R:R:D77	R:R:L80	4.07	Yes	Yes	1	9	5
223	R:R:D77	R:R:W82	8.93	Yes	No	0	9	9
224	R:R:D77	R:R:S129	4.42	Yes	Yes	1	9	7
225	R:R:D77	R:R:Y131	5.75	Yes	Yes	1	9	5
226	R:R:W79	R:R:Y98	5.79	Yes	Yes	1	6	4
227	R:R:F99	R:R:W79	9.02	Yes	Yes	1	5	6
228	R:R:F102	R:R:W79	7.02	Yes	Yes	1	4	6
229	R:R:W79	R:R:Y131	19.29	Yes	Yes	1	6	5
230	R:R:L80	R:R:Q93	3.99	Yes	No	0	5	6
231	R:R:L80	R:R:P96	11.49	Yes	Yes	1	5	9
232	R:R:L80	R:R:V108	4.47	Yes	No	1	5	7
233	R:R:L80	R:R:Y131	5.86	Yes	Yes	1	5	5
234	R:R:Q93	R:R:W82	19.71	No	No	0	6	9
235	R:R:K110	R:R:W82	19.73	Yes	No	0	8	9
236	R:R:P86	R:R:T85	3.5	Yes	Yes	4	2	7
237	R:R:S91	R:R:T85	6.4	No	Yes	0	5	7
238	R:R:C112	R:R:T85	3.38	No	Yes	4	9	7
239	R:R:T85	R:R:W118	8.49	Yes	Yes	4	7	9
240	R:R:P86	R:R:V89	10.6	Yes	No	0	2	5
241	R:R:G88	R:R:Y111	2.9	No	No	0	8	4
242	R:R:L90	R:R:Y92	5.86	No	No	5	4	4
243	R:R:L90	R:R:T109	4.42	No	Yes	5	4	5
244	R:R:L90	R:R:Y111	5.86	No	No	0	4	4
245	R:R:K107	R:R:Y92	11.94	No	No	0	3	4
246	R:R:T109	R:R:Y92	6.24	Yes	No	5	5	4
247	R:R:F94	R:R:K107	7.44	No	No	0	3	3
248	R:R:C95	R:R:P96	3.77	No	Yes	1	9	9
249	R:R:C95	R:R:F102	6.98	No	Yes	1	9	4
250	R:R:C134	R:R:C95	7.28	No	No	1	9	9
251	R:R:P96	R:R:Y98	13.91	Yes	Yes	1	9	4
252	R:R:F102	R:R:P96	2.89	Yes	Yes	1	4	9
253	R:R:F99	R:R:Y98	3.09	Yes	Yes	1	5	4
254	R:R:D101	R:R:F99	3.58	Yes	Yes	1	4	5
255	R:R:F102	R:R:F99	12.86	Yes	Yes	1	4	5
256	R:R:D101	R:R:N135	12.12	Yes	No	1	4	3
257	R:R:C134	R:R:F102	5.59	No	Yes	1	9	4
258	R:R:F102	R:R:N135	7.25	Yes	No	1	4	3
259	R:R:D103	R:R:P104	6.44	Yes	No	0	3	3
260	R:R:D103	R:R:S105	8.83	Yes	No	5	3	1
261	R:R:D103	R:R:E106	6.5	Yes	Yes	5	3	4
262	R:R:D103	R:R:K141	2.77	Yes	No	0	3	3
263	R:R:E106	R:R:S105	4.31	Yes	No	5	4	1
264	R:R:E106	R:R:M133	2.71	Yes	No	5	4	5
265	R:R:E106	R:R:F137	3.5	Yes	No	0	4	1
266	R:R:V108	R:R:Y131	10.09	No	Yes	1	7	5
267	R:R:N130	R:R:T109	4.39	Yes	Yes	5	8	5
268	R:R:M133	R:R:T109	3.01	No	Yes	5	5	5
269	R:R:K110	R:R:W118	15.08	Yes	Yes	0	8	9
270	R:R:K110	R:R:T127	3	Yes	No	0	8	4
271	R:R:K110	R:R:S129	10.71	Yes	Yes	0	8	7
272	R:R:C112	R:R:W118	5.22	No	Yes	4	9	9
273	R:R:D113	R:R:E114	10.39	No	No	0	5	2
274	R:R:H121	R:R:P122	10.68	No	No	0	4	5
275	R:R:H121	R:R:W128	19.04	No	No	0	4	5
276	R:R:E123	R:R:N124	13.15	No	No	0	4	5
277	R:R:N130	R:R:W128	7.91	Yes	No	0	8	5
278	R:R:S129	R:R:Y131	5.09	Yes	Yes	1	7	5
279	R:R:N130	R:R:T132	4.39	Yes	No	0	8	6
280	R:R:M133	R:R:N130	5.61	No	Yes	5	5	8
281	R:R:A136	R:R:F137	8.32	No	No	0	2	1
282	R:R:F137	R:R:K366	6.2	No	No	0	1	3
283	R:R:P139	R:R:T138	3.5	No	No	0	3	2
284	R:R:K370	R:R:N144	2.8	No	No	7	4	4
285	R:R:N144	R:R:Y374	4.65	No	Yes	7	4	6
286	R:R:Y146	R:R:Y150	3.97	No	No	8	2	4
287	R:R:V147	R:R:Y374	5.05	No	Yes	0	4	6
288	R:R:D373	R:R:L148	5.43	No	Yes	0	5	5
289	R:R:L148	R:R:Y374	4.69	Yes	Yes	7	5	6
290	R:R:H377	R:R:L148	18	Yes	Yes	7	7	5
291	R:R:Y149	R:R:Y150	11.91	Yes	No	8	5	4
292	R:R:I153	R:R:Y149	8.46	No	Yes	8	7	5
293	R:R:L202	R:R:Y149	4.69	Yes	Yes	8	7	5
294	R:R:L151	R:R:S378	6.01	No	No	0	5	5
295	R:R:F382	R:R:L151	3.65	No	No	0	7	5
296	R:R:A152	R:R:H381	7.32	No	No	0	7	9
297	R:R:I153	R:R:L202	2.85	No	Yes	8	7	7
298	R:R:F382	R:R:G155	9.03	No	No	0	7	8
299	R:R:H156	R:R:S195	11.16	Yes	No	0	7	7
300	R:R:H156	R:R:I198	11.93	Yes	Yes	0	7	7
301	R:R:H156	R:R:H381	10.75	Yes	No	0	7	9
302	R:R:I199	R:R:S157	3.1	No	No	0	7	7
303	R:R:F385	R:R:L158	7.31	Yes	No	0	5	4
304	R:R:G384	R:R:S159	3.71	No	No	0	9	9
305	R:R:I160	R:R:S195	4.64	No	No	0	5	7
306	R:R:F161	R:R:I165	3.77	No	No	0	4	5
307	R:R:F385	R:R:T162	7.78	Yes	No	0	5	6
308	R:R:A388	R:R:T162	3.36	No	No	0	8	6
309	R:R:F393	R:R:T162	3.89	Yes	No	0	8	6
310	R:R:F188	R:R:L163	4.87	Yes	No	0	8	8
311	R:R:I192	R:R:L163	5.71	No	No	0	7	8
312	R:R:A388	R:R:L163	3.15	No	No	0	8	8
313	R:R:F393	R:R:I165	3.77	Yes	No	0	8	5
314	R:R:F188	R:R:S166	5.28	Yes	No	0	8	9
315	R:R:A388	R:R:S166	3.42	No	No	0	8	9
316	R:R:C392	R:R:S166	6.89	No	No	0	9	9
317	R:R:L167	R:R:V171	2.98	No	No	0	6	4
318	R:R:K185	R:R:L167	4.23	No	No	0	6	6
319	R:R:F173	R:R:I169	7.54	Yes	No	0	7	8
320	R:R:F170	R:R:V181	10.49	Yes	Yes	12	8	9
321	R:R:F170	R:R:K185	3.72	Yes	No	12	8	6
322	R:R:F170	R:R:F188	5.36	Yes	Yes	0	8	8
323	R:R:C392	R:R:F170	6.98	No	Yes	0	9	8
324	R:R:F172	R:R:F173	8.57	No	Yes	9	2	7
325	R:R:F172	R:R:Q405	5.86	No	No	9	2	4
326	R:R:F173	R:R:T401	3.89	Yes	Yes	9	7	7
327	R:R:F173	R:R:Q405	9.37	Yes	No	9	7	4
328	R:R:L176	R:R:S175	3	No	No	9	9	8
329	R:R:S175	R:R:T401	3.2	No	Yes	9	8	7
330	R:R:L176	R:R:V398	4.47	No	No	0	9	9
331	R:R:L176	R:R:T401	2.95	No	Yes	9	9	7
332	R:R:C178	R:R:R180	5.57	No	No	12	8	9
333	R:R:C178	R:R:V181	3.42	No	Yes	12	8	9
334	R:R:Q179	R:R:Y243	9.02	Yes	Yes	13	7	8
335	R:R:K256	R:R:Q179	4.07	No	Yes	0	5	7
336	R:R:Q179	R:R:Q257	3.84	Yes	Yes	13	7	5
337	R:R:L259	R:R:Q179	6.65	Yes	Yes	0	5	7
338	R:R:R180	R:R:V181	3.92	No	Yes	12	9	9
339	R:R:H184	R:R:R180	6.77	No	No	0	9	9
340	R:R:K185	R:R:V181	3.04	No	Yes	12	6	9
341	R:R:L183	R:R:Y243	7.03	No	Yes	0	8	8
342	R:R:L183	R:R:L259	4.15	No	Yes	0	8	5
343	R:R:E240	R:R:H184	8.62	No	No	0	9	9
344	R:R:N186	R:R:W236	13.56	No	Yes	3	9	9
345	R:R:N186	R:R:Y263	9.3	No	No	3	9	5
346	R:R:M187	R:R:T190	3.01	Yes	Yes	3	8	9
347	R:R:M187	R:R:Y191	8.38	Yes	Yes	3	8	8
348	R:R:M187	R:R:M237	2.89	Yes	Yes	3	8	9
349	R:R:E240	R:R:M187	8.12	No	Yes	3	9	8
350	R:R:L351	R:R:M187	2.83	Yes	Yes	3	9	8
351	R:R:F188	R:R:V387	5.24	Yes	No	0	8	9
352	R:R:L189	R:R:L193	5.54	No	No	0	3	6
353	R:R:N233	R:R:T190	8.77	No	Yes	3	9	9
354	R:R:T190	R:R:W236	4.85	Yes	Yes	3	9	9
355	R:R:T190	R:R:W267	3.64	Yes	No	3	9	9
356	R:R:N233	R:R:Y191	15.12	No	Yes	3	9	8
357	R:R:M237	R:R:Y191	5.99	Yes	Yes	3	9	8
358	R:R:Q383	R:R:Y191	14.65	Yes	Yes	3	9	8
359	R:R:G384	R:R:Y191	7.24	No	Yes	0	9	8
360	R:R:V387	R:R:Y191	3.79	No	Yes	0	9	8
361	R:R:L193	R:R:M229	7.07	No	No	0	6	4
362	R:R:I198	R:R:N194	5.66	Yes	No	0	7	8
363	R:R:M230	R:R:N194	2.8	Yes	No	0	6	8
364	R:R:H226	R:R:I197	5.3	No	No	0	6	5
365	R:R:I197	R:R:M229	2.92	No	No	0	5	4
366	R:R:I198	R:R:L202	2.85	Yes	Yes	0	7	7
367	R:R:H226	R:R:I198	3.98	No	Yes	0	6	7
368	R:R:E204	R:R:I200	2.73	No	No	0	4	6
369	R:R:H201	R:R:V205	11.07	Yes	No	0	6	7
370	R:R:H201	R:R:V206	2.77	Yes	No	0	6	3
371	R:R:L202	R:R:V206	2.98	Yes	No	0	7	3
372	R:R:E204	R:R:V203	4.28	No	No	0	4	3
373	R:R:P207	R:R:V206	5.3	No	No	0	3	3
374	R:R:E210	R:R:N208	5.26	No	No	0	3	3
375	R:R:L211	R:R:N208	8.24	No	No	0	1	3
376	R:R:E210	R:R:R213	3.49	No	No	0	3	2
377	R:R:E210	R:R:R214	15.12	No	No	0	3	4
378	R:R:L211	R:R:R214	3.64	No	No	0	1	4
379	R:R:L211	R:R:P216	3.28	No	No	0	1	4
380	R:R:C289	R:R:V212	6.83	No	Yes	17	9	3
381	R:R:L291	R:R:V212	2.98	Yes	Yes	17	6	3
382	R:R:D215	R:R:K220	8.3	No	No	0	6	7
383	R:R:P216	R:R:S218	3.56	No	No	0	4	3
384	R:R:I221	R:R:V217	3.07	No	No	0	4	3
385	R:R:C219	R:R:C289	7.28	No	No	0	9	9
386	R:R:K220	R:R:N286	4.2	No	No	2	7	7
387	R:R:K220	R:R:W290	18.57	No	Yes	2	7	9
388	R:R:F225	R:R:I221	3.77	No	No	0	5	4
389	R:R:H223	R:R:Q227	13.6	No	Yes	0	5	7
390	R:R:H223	R:R:W290	10.58	No	Yes	0	5	9
391	R:R:F224	R:R:F225	4.29	Yes	No	0	5	5
392	R:R:F224	R:R:T274	5.19	Yes	No	0	5	6
393	R:R:A278	R:R:F224	2.77	No	Yes	0	6	5
394	R:R:M230	R:R:Q227	2.72	Yes	Yes	2	6	7
395	R:R:H277	R:R:Q227	9.89	Yes	Yes	2	7	7
396	R:R:I301	R:R:Q227	6.86	Yes	Yes	2	7	7
397	R:R:M229	R:R:Y228	5.99	No	No	0	4	8
398	R:R:C232	R:R:Y228	9.41	No	No	0	8	8
399	R:R:L271	R:R:Y228	4.69	No	No	0	4	8
400	R:R:M230	R:R:Y234	4.79	Yes	Yes	0	6	7
401	R:R:H302	R:R:M230	7.88	Yes	Yes	2	6	6
402	R:R:C232	R:R:W267	5.22	No	No	0	8	9
403	R:R:C232	R:R:P270	5.65	No	Yes	0	8	9
404	R:R:M237	R:R:N233	2.8	Yes	No	3	9	9
405	R:R:M237	R:R:Y234	3.59	Yes	Yes	0	9	7
406	R:R:V305	R:R:Y234	7.57	No	Yes	0	7	7
407	R:R:F356	R:R:Y234	11.35	Yes	Yes	0	7	7
408	R:R:F235	R:R:F269	8.57	Yes	Yes	6	5	3
409	R:R:F235	R:R:P270	5.78	Yes	Yes	6	5	9
410	R:R:A308	R:R:F235	2.77	No	Yes	0	7	5
411	R:R:C239	R:R:W236	7.84	No	Yes	0	7	9
412	R:R:W236	R:R:Y263	3.86	Yes	No	3	9	5
413	R:R:G266	R:R:W236	8.44	No	Yes	0	9	9
414	R:R:W236	R:R:W267	14.99	Yes	No	3	9	9
415	R:R:M237	R:R:Q383	5.44	Yes	Yes	3	9	9
416	R:R:I242	R:R:L238	7.14	Yes	Yes	0	7	8
417	R:R:L238	R:R:L265	2.77	Yes	Yes	0	8	7
418	R:R:A308	R:R:L238	3.15	No	Yes	0	7	8
419	R:R:L238	R:R:V311	2.98	Yes	No	0	8	6
420	R:R:L238	R:R:N312	5.49	Yes	No	0	8	9
421	R:R:C239	R:R:Y262	5.38	No	Yes	0	7	7
422	R:R:C239	R:R:L265	4.76	No	Yes	0	7	7
423	R:R:E240	R:R:L351	10.6	No	Yes	3	9	9
424	R:R:I242	R:R:Y262	4.84	Yes	Yes	0	7	7
425	R:R:F315	R:R:I242	3.77	No	Yes	0	8	7
426	R:R:L247	R:R:Y243	8.21	No	Yes	13	8	8
427	R:R:Q257	R:R:Y243	6.76	Yes	Yes	13	5	8
428	R:R:Y243	R:R:Y262	5.96	Yes	Yes	13	8	7
429	R:R:I319	R:R:L244	4.28	No	No	0	9	9
430	R:R:L244	R:R:L348	2.77	No	No	0	9	9
431	R:R:H245	R:R:V249	13.84	Yes	No	18	8	6
432	R:R:H245	R:R:V250	2.77	Yes	No	0	8	5
433	R:R:F315	R:R:H245	23.76	No	Yes	0	8	8
434	R:R:H245	R:R:N318	11.48	Yes	No	18	8	8
435	R:R:Q257	R:R:T246	4.25	Yes	No	0	5	7
436	R:R:L247	R:R:Q257	3.99	No	Yes	13	8	5
437	R:R:I248	R:R:V249	3.07	No	No	0	7	6
438	R:R:I248	R:R:V322	3.07	No	No	0	7	8
439	R:R:N318	R:R:V249	8.87	No	No	18	8	6
440	R:R:Q257	R:R:T254	4.25	Yes	No	0	5	6
441	R:R:E255	R:R:K256	4.05	No	No	0	6	5
442	R:R:Q257	R:R:Y262	4.51	Yes	Yes	13	5	7
443	R:R:R258	R:R:R260	10.66	Yes	No	11	5	3
444	R:R:R258	R:R:W261	11	Yes	Yes	11	5	2
445	R:R:L259	R:R:Y263	8.21	Yes	No	0	5	5
446	R:R:R260	R:R:W261	3	No	Yes	11	3	2
447	R:R:F269	R:R:L265	3.65	Yes	Yes	0	3	7
448	R:R:F269	R:R:P270	4.33	Yes	Yes	6	3	9
449	R:R:P273	R:R:V272	5.3	No	No	0	6	4
450	R:R:I301	R:R:T274	6.08	Yes	No	0	7	6
451	R:R:I276	R:R:I300	4.42	No	Yes	0	5	8
452	R:R:H277	R:R:R281	11.28	Yes	Yes	2	7	7
453	R:R:H277	R:R:L298	3.86	Yes	No	0	7	6
454	R:R:H277	R:R:I300	3.98	Yes	Yes	0	7	8
455	R:R:H277	R:R:I301	7.95	Yes	Yes	2	7	7
456	R:R:L297	R:R:T280	11.79	Yes	No	0	4	4
457	R:R:I300	R:R:T280	4.56	Yes	No	0	8	4
458	R:R:F285	R:R:R281	7.48	Yes	Yes	2	6	7
459	R:R:D287	R:R:R281	3.57	No	Yes	2	3	7
460	R:R:R281	R:R:W290	13	Yes	Yes	2	7	9
461	R:R:R281	R:R:T295	5.17	Yes	Yes	2	7	4
462	R:R:L297	R:R:R281	4.86	Yes	Yes	2	4	7
463	R:R:V283	R:R:Y284	8.83	No	No	0	3	2
464	R:R:D287	R:R:F285	3.58	No	Yes	2	3	6
465	R:R:F285	R:R:S292	6.61	Yes	No	2	6	4
466	R:R:F285	R:R:T295	20.75	Yes	Yes	2	6	4
467	R:R:N286	R:R:W290	3.39	No	Yes	2	7	9
468	R:R:D287	R:R:S292	5.89	No	No	2	3	4
469	R:R:C289	R:R:L291	4.76	No	Yes	17	9	6
470	R:R:E294	R:R:S292	2.87	No	No	0	3	4
471	R:R:E294	R:R:V293	2.85	No	No	0	3	6
472	R:R:L298	R:R:V293	2.98	No	No	0	6	6
473	R:R:L297	R:R:T295	4.42	Yes	Yes	2	4	4
474	R:R:G303	R:R:P304	4.06	No	No	6	4	9
475	R:R:F356	R:R:L309	3.65	Yes	No	0	7	7
476	R:R:F314	R:R:V310	5.24	No	No	0	5	4
477	R:R:F315	R:R:V311	5.24	No	No	0	8	6
478	R:R:L352	R:R:N312	8.24	Yes	No	0	9	9
479	R:R:F313	R:R:L317	7.31	Yes	No	0	6	5
480	R:R:F313	R:R:V357	5.24	Yes	No	0	6	7
481	R:R:L316	R:R:V320	2.98	No	No	0	9	7
482	R:R:L316	R:R:L348	4.15	No	No	0	9	9
483	R:R:I354	R:R:L316	7.14	Yes	No	0	6	9
484	R:R:N318	R:R:R321	8.44	No	No	0	8	8
485	R:R:T345	R:R:V320	3.17	No	No	0	9	7
486	R:R:K326	R:R:V322	3.04	No	No	0	9	8
487	R:R:R328	R:R:V324	6.54	No	No	0	6	5
488	R:R:E332	R:R:M327	2.71	No	Yes	0	5	7
489	R:R:M327	R:R:M337	5.78	Yes	Yes	0	7	7
490	R:R:K340	R:R:M327	2.88	No	Yes	0	8	7
491	R:R:E332	R:R:T330	8.47	No	No	0	5	5
492	R:R:H336	R:R:S335	5.58	No	No	0	6	6
493	R:R:M337	R:R:Y338	4.79	Yes	No	0	7	7
494	R:R:K340	R:R:K343	2.87	No	No	0	8	8
495	R:R:M346	R:R:V342	4.56	No	No	0	8	8
496	R:R:I347	R:R:I390	5.89	No	No	3	8	8
497	R:R:I347	R:R:Y391	6.04	No	Yes	3	8	8
498	R:R:L348	R:R:Y391	3.52	No	Yes	0	9	8
499	R:R:P350	R:R:V349	5.3	No	No	0	9	8
500	R:R:I354	R:R:V349	7.68	Yes	No	0	6	8
501	R:R:Q355	R:R:V349	2.87	Yes	No	0	8	8
502	R:R:F386	R:R:P350	4.33	No	No	0	5	9
503	R:R:L351	R:R:L352	2.77	Yes	Yes	0	9	9
504	R:R:L351	R:R:Y391	11.72	Yes	Yes	3	9	8
505	R:R:I354	R:R:L352	4.28	Yes	Yes	0	6	9
506	R:R:G353	R:R:Q355	4.93	No	Yes	3	9	8
507	R:R:F356	R:R:G353	3.01	Yes	No	3	7	9
508	R:R:F356	R:R:Q355	9.37	Yes	Yes	3	7	8
509	R:R:Q355	R:R:Q383	8.96	Yes	Yes	3	8	9
510	R:R:F356	R:R:I380	7.54	Yes	No	0	7	6
511	R:R:F356	R:R:Q383	4.68	Yes	Yes	3	7	9
512	R:R:F359	R:R:V358	7.87	No	No	0	6	5
513	R:R:F359	R:R:Y372	4.13	No	Yes	10	6	7
514	R:R:F359	R:R:M376	3.73	No	No	10	6	7
515	R:R:P363	R:R:R362	2.88	Yes	Yes	10	7	4
516	R:R:G369	R:R:R362	6	No	Yes	10	4	4
517	R:R:R362	R:R:Y372	7.2	Yes	Yes	10	4	7
518	R:R:D373	R:R:R362	13.1	No	Yes	0	5	4
519	R:R:L368	R:R:P363	3.28	No	Yes	0	3	7
520	R:R:G369	R:R:P363	4.06	No	Yes	10	4	7
521	R:R:P363	R:R:Y372	9.74	Yes	Yes	10	7	7
522	R:R:M367	R:R:N365	2.8	No	No	0	4	4
523	R:R:L368	R:R:N365	8.24	No	No	0	3	4
524	R:R:K370	R:R:M367	2.88	No	No	0	4	4
525	R:R:K370	R:R:Y374	3.58	No	Yes	7	4	6
526	R:R:M376	R:R:Y372	14.37	No	Yes	10	7	7
527	R:R:L379	R:R:V375	2.98	No	No	0	5	4
528	R:R:I380	R:R:M376	2.92	No	No	0	6	7
529	R:R:H377	R:R:H381	9.55	Yes	No	0	7	9
530	R:R:F382	R:R:F386	3.22	No	No	0	7	5
531	R:R:F385	R:R:F386	4.29	Yes	No	0	5	5
532	R:R:F385	R:R:T389	7.78	Yes	No	0	5	5
533	R:R:V387	R:R:Y391	5.05	No	Yes	0	9	8
534	R:R:F393	R:R:T389	6.49	Yes	No	0	8	5
535	R:R:I390	R:R:Y391	3.63	No	Yes	3	8	8
536	R:R:C392	R:R:F393	2.79	No	Yes	0	9	8
537	R:R:E397	R:R:N395	15.77	No	No	0	9	9
538	R:R:N395	R:R:V398	7.39	No	No	0	9	9
539	R:R:N396	R:R:T400	2.92	No	No	0	6	4
540	R:R:R404	R:R:T401	3.88	No	Yes	0	7	7
541	R:R:F409	R:R:Q405	3.51	No	No	0	3	4
542	R:R:F409	R:R:W406	3.01	No	No	0	3	6
543	L:L:C2	R:R:Y299	2.69	Yes	No	0	0	7
544	R:R:A51	R:R:Y98	2.67	No	Yes	0	8	4
545	R:R:L379	R:R:Q355	2.66	No	Yes	0	5	8
546	R:R:H156	R:R:I199	2.65	Yes	No	0	7	7
547	E:E:N31	E:E:Q28	2.64	No	No	0	2	4
548	E:E:F44	E:E:S65	2.64	Yes	No	1	9	4
549	E:E:R102	E:E:S103	2.64	No	No	0	5	7
550	E:E:V129	R:R:F269	2.62	No	Yes	0	7	3
551	L:L:V32	R:R:F102	2.62	No	Yes	0	0	4
552	R:R:F170	R:R:V398	2.62	Yes	No	0	8	9
553	R:R:F173	R:R:V402	2.62	Yes	No	0	7	5
554	R:R:H201	R:R:L291	2.57	Yes	Yes	0	6	6
555	R:R:V203	R:R:Y149	2.52	No	Yes	0	3	5
556	E:E:F122	E:E:I118	2.51	No	No	0	9	7
557	R:R:F313	R:R:I354	2.51	Yes	Yes	0	6	6
558	R:R:M337	R:R:R328	2.48	Yes	No	0	7	6
559	E:E:V137	R:R:W261	2.45	No	Yes	0	9	2
560	L:L:T4	R:R:W361	2.43	Yes	No	0	0	4
561	E:E:I123	R:R:Y299	2.42	No	No	0	9	7
562	R:R:K47	R:R:Y98	2.39	No	Yes	0	4	4
563	R:R:F313	R:R:F314	2.14	Yes	No	0	6	5
564	L:L:G20	L:L:G21	2.11	No	No	0	0	0
565	E:E:G116	E:E:P115	2.03	No	No	0	5	9
566	R:R:G268	R:R:P270	2.03	No	Yes	0	6	9
567	R:R:C178	R:R:G177	1.96	No	No	0	8	7
568	E:E:C104	E:E:P105	1.88	No	No	0	9	7
569	R:R:C219	R:R:P216	1.88	No	No	0	9	4
570	R:R:A231	R:R:P270	1.87	No	Yes	0	5	9
571	L:L:G14	L:L:S17	1.86	No	No	0	0	0
572	R:R:G209	R:R:V212	1.84	No	Yes	0	3	3
573	L:L:V22	R:R:P100	1.77	No	No	0	0	4
574	R:R:G116	R:R:K115	1.74	No	No	0	9	5
575	R:R:G241	R:R:L352	1.71	No	Yes	0	8	9
576	R:R:G268	R:R:L264	1.71	No	No	0	6	3
577	R:R:A333	R:R:S335	1.71	No	No	0	5	6
578	E:E:A110	E:E:V111	1.7	No	No	0	4	5
579	L:L:G33	L:L:N31	1.7	No	No	0	0	0
580	R:R:A251	R:R:V250	1.7	No	No	0	6	5
581	R:R:I301	R:R:P273	1.69	Yes	No	0	7	6
582	R:R:C394	R:R:T389	1.69	No	No	0	5	5
583	R:R:M306	R:R:P360	1.68	No	No	0	4	5
584	E:E:G98	R:R:Q60	1.64	No	No	0	5	3
585	R:R:E68	R:R:G67	1.64	No	No	0	1	2
586	E:E:C40	E:E:M76	1.62	No	No	0	9	4
587	E:E:I127	R:R:A307	1.62	No	No	0	8	3
588	L:L:P29	R:R:D101	1.61	No	Yes	0	0	4
589	R:R:V320	R:R:V324	1.6	No	No	0	7	5
590	E:E:T128	E:E:V124	1.59	No	No	0	5	6
591	E:E:L131	R:R:A307	1.58	No	No	0	8	3
592	R:R:A344	R:R:L323	1.58	No	No	0	9	9
593	R:R:T400	R:R:T401	1.57	No	Yes	0	4	7
594	E:E:A87	E:E:N86	1.56	No	Yes	0	4	9
595	R:R:I160	R:R:V164	1.54	No	No	0	5	4
596	R:R:I192	R:R:V164	1.54	No	No	0	7	4
597	R:R:I371	R:R:V375	1.54	No	No	0	5	4
598	R:R:K115	R:R:V117	1.52	No	No	0	5	5
599	R:R:K120	R:R:V117	1.52	No	No	0	1	5
600	R:R:I279	R:R:T275	1.52	No	No	0	3	3
601	R:R:A407	R:R:Q408	1.52	No	No	0	4	7
602	E:E:A34	E:E:E38	1.51	No	No	0	2	4
603	E:E:A50	E:E:E49	1.51	No	No	0	5	3
604	R:R:L222	R:R:V205	1.49	No	No	0	6	7
605	R:R:N288	R:R:V212	1.48	No	Yes	0	4	3
606	R:R:L142	R:R:T138	1.47	Yes	No	0	2	2
607	R:R:L259	R:R:T182	1.47	Yes	No	0	5	5
608	R:R:D113	R:R:V117	1.46	No	No	0	5	5
609	R:R:I160	R:R:M196	1.46	No	No	0	5	4
610	R:R:I192	R:R:M196	1.46	No	No	0	7	4
611	R:R:D83	R:R:T85	1.45	No	Yes	0	5	7
612	R:R:F119	R:R:P122	1.44	No	No	0	4	5
613	E:E:G52	E:E:W56	1.41	No	Yes	0	5	5
614	R:R:L323	R:R:M327	1.41	No	Yes	0	9	7
615	R:R:E329	R:R:T325	1.41	No	No	0	6	7
616	E:E:P121	E:E:Y120	1.39	No	No	0	7	5
617	R:R:K403	R:R:Q399	1.36	No	No	0	6	7
618	R:R:E140	R:R:K143	1.35	No	No	0	2	1
619	R:R:E334	R:R:M337	1.35	No	Yes	0	6	7
620	E:E:E38	E:E:L35	1.33	No	Yes	15	4	2
621	E:E:E38	E:E:L39	1.33	No	No	15	4	1
622	R:R:R45	R:R:V42	1.31	Yes	No	0	7	1
623	R:R:F224	R:R:T275	1.3	Yes	No	0	5	3
624	R:R:A282	R:R:W290	1.3	No	Yes	0	3	9
625	E:E:L136	E:E:W139	1.14	No	No	0	7	6
626	R:R:E114	R:R:Y111	1.12	No	No	0	2	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	E:E:Y32	5.9875	4	1	5
2	E:E:L35	3.4475	4	15	2
3	E:E:F44	5.6	5	1	9
4	E:E:D47	5.0925	4	1	5
5	E:E:M48	7.538	5	1	9
6	E:E:W56	8.805	4	1	5
7	E:E:W59	9.4925	4	1	7
8	E:E:Y66	6.735	4	1	9
9	E:E:W84	7.87167	6	1	7
10	E:E:N86	5.8875	4	1	9
11	E:E:E88	6.0825	4	1	4
12	E:E:F92	7.0975	4	0	5
13	E:E:F93	10.0075	4	1	9
14	E:E:H97	9.018	5	1	9
15	E:E:Y100	9.03	5	1	8
16	E:E:F101	6.574	5	1	9
17	E:E:D113	5.41	4	2	9
18	E:E:P114	6.6825	4	0	9
19	E:E:Q140	10.9325	4	11	8
20	L:L:C2	4.506	5	2	0
21	L:L:T4	3.684	5	2	0
22	L:L:T6	7.2625	4	2	0
23	L:L:T30	9.3825	4	1	0
24	L:L:?37	5.84222	9	1	0
25	L:L:?101	8.3	5	8	0
26	R:R:R45	3.5575	4	1	7
27	R:R:M49	4.342	5	1	4
28	R:R:Q52	6.65167	6	1	6
29	R:R:Y53	12.22	5	1	1
30	R:R:Y56	7.97714	7	1	3
31	R:R:M59	5.25	4	1	5
32	R:R:Y65	8.41	4	4	3
33	R:R:W76	7.27	6	1	8
34	R:R:D77	4.97	6	1	9
35	R:R:W79	9.36167	6	1	6
36	R:R:L80	5.976	5	1	5
37	R:R:T85	4.43333	6	4	7
38	R:R:P86	6.4875	4	4	2
39	R:R:P96	8.015	4	1	9
40	R:R:Y98	6.23833	6	1	4
41	R:R:F99	9.86	5	1	5
42	R:R:D101	6.152	5	1	4
43	R:R:F102	6.3	8	1	4
44	R:R:D103	6.135	4	5	3
45	R:R:E106	4.255	4	5	4
46	R:R:T109	4.515	4	5	5
47	R:R:K110	12.13	4	0	8
48	R:R:W118	9.228	5	4	9
49	R:R:S129	6.575	4	1	7
50	R:R:N130	5.575	4	5	8
51	R:R:Y131	8.31333	6	1	5
52	R:R:L142	4.025	4	16	2
53	R:R:L148	7.7225	4	7	5
54	R:R:Y149	6.22	5	8	5
55	R:R:H156	9.1225	4	0	7
56	R:R:F170	5.834	5	12	8
57	R:R:F173	6.398	5	9	7
58	R:R:Q179	5.895	4	13	7
59	R:R:V181	5.2175	4	12	9
60	R:R:M187	5.046	5	3	8
61	R:R:F188	5.1875	4	0	8
62	R:R:T190	5.0675	4	3	9
63	R:R:Y191	9.195	6	3	8
64	R:R:I198	5.492	5	0	7
65	R:R:H201	4.835	4	0	6
66	R:R:L202	3.3425	4	8	7
67	R:R:V212	3.2825	4	17	3
68	R:R:F224	3.3875	4	0	5
69	R:R:Q227	8.2675	4	2	7
70	R:R:M230	4.952	5	2	6
71	R:R:Y234	7.208	5	0	7
72	R:R:F235	5.2525	4	6	5
73	R:R:W236	8.92333	6	3	9
74	R:R:M237	4.142	5	3	9
75	R:R:L238	4.81667	6	0	8
76	R:R:I242	5.3	5	0	7
77	R:R:Y243	7.396	5	13	8
78	R:R:H245	12.9625	4	18	8
79	R:R:Q257	4.6	6	13	5
80	R:R:R258	10.7075	4	11	5
81	R:R:L259	5.12	4	0	5
82	R:R:W261	8.22	4	11	2
83	R:R:Y262	5.1725	4	13	7
84	R:R:L265	4.6575	4	0	7
85	R:R:F269	6.24333	6	6	3
86	R:R:P270	3.932	5	6	9
87	R:R:H277	7.392	5	2	7
88	R:R:R281	7.56	6	2	7
89	R:R:F285	8.92833	6	2	6
90	R:R:W290	9.368	5	2	9
91	R:R:L291	3.7025	4	17	6
92	R:R:T295	9.7525	4	2	4
93	R:R:L297	6.5	4	2	4
94	R:R:I300	4.0875	4	0	8
95	R:R:I301	5.645	4	2	7
96	R:R:H302	8.112	5	2	6
97	R:R:F313	4.3	4	0	6
98	R:R:M327	3.195	4	0	7
99	R:R:M337	3.6	4	0	7
100	R:R:L351	6.98	4	3	9
101	R:R:L352	4.25	4	0	9
102	R:R:I354	5.4025	4	0	6
103	R:R:Q355	5.758	5	3	8
104	R:R:F356	6.25143	7	3	7
105	R:R:R362	7.295	4	10	4
106	R:R:P363	4.99	4	10	7
107	R:R:Y372	8.86	4	10	7
108	R:R:Y374	4.4925	4	7	6
109	R:R:H377	10.225	4	7	7
110	R:R:Q383	8.4325	4	3	9
111	R:R:F385	6.79	4	0	5
112	R:R:Y391	5.992	5	3	8
113	R:R:F393	4.235	4	0	8
114	R:R:T401	3.098	5	9	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	E:E:C27	E:E:E29	10.1821	3.04	No	No	0	8	5
2	E:E:E29	E:E:N86	10.8931	5.26	No	Yes	0	5	9
3	E:E:N86	E:E:Y32	12.253	12.79	Yes	Yes	1	9	5
4	E:E:V89	E:E:Y32	15.8092	3.79	No	Yes	1	8	5
5	E:E:F44	E:E:L69	11.1778	14.61	Yes	No	0	9	8
6	E:E:V89	E:E:W84	15.4744	6.13	No	Yes	1	8	7
7	E:E:W84	R:R:Q52	37.4471	4.38	Yes	Yes	1	7	6
8	E:E:F93	R:R:Q52	19.132	9.37	Yes	Yes	1	9	6
9	E:E:F93	E:E:L69	11.7143	4.87	Yes	No	0	9	8
10	R:R:Q52	R:R:Y56	10.0403	5.64	Yes	Yes	1	6	3
11	E:E:W84	L:L:?37	59.145	3.69	Yes	Yes	1	7	0
12	L:L:?37	R:R:W128	87.9237	6.46	Yes	No	0	0	5
13	R:R:N130	R:R:W128	90.9738	7.91	Yes	No	0	8	5
14	R:R:M133	R:R:N130	89.096	5.61	No	Yes	5	5	8
15	R:R:E106	R:R:M133	95.8942	2.71	Yes	No	5	4	5
16	R:R:D103	R:R:E106	96.8233	6.5	Yes	Yes	5	3	4
17	R:R:D103	R:R:K141	98.145	2.77	Yes	No	0	3	3
18	L:L:L15	R:R:K141	98.4166	4.23	No	No	0	0	3
19	L:L:L15	R:R:L142	98.4657	4.15	No	Yes	16	0	2
20	L:L:V23	R:R:L142	99.7415	4.47	No	Yes	0	0	2
21	L:L:V23	R:R:Y146	100	10.09	No	No	0	0	2
22	R:R:Y146	R:R:Y150	56.4787	3.97	No	No	8	2	4
23	R:R:Y149	R:R:Y150	59.3228	11.91	Yes	No	8	5	4
24	R:R:L202	R:R:Y149	52.482	4.69	Yes	Yes	8	7	5
25	R:R:I198	R:R:L202	59.3893	2.85	Yes	Yes	0	7	7
26	R:R:I198	R:R:N194	36.9826	5.66	Yes	No	0	7	8
27	R:R:M230	R:R:N194	36.9902	2.8	Yes	No	0	6	8
28	R:R:M230	R:R:Q227	31.7983	2.72	Yes	Yes	2	6	7
29	R:R:H277	R:R:Q227	20.1265	9.89	Yes	Yes	2	7	7
30	R:R:H277	R:R:R281	15.3402	11.28	Yes	Yes	2	7	7
31	R:R:H226	R:R:I198	20.9542	3.98	No	Yes	0	6	7
32	R:R:H226	R:R:I197	17.4755	5.3	No	No	0	6	5
33	R:R:I197	R:R:M229	17.1254	2.92	No	No	0	5	4
34	R:R:M229	R:R:Y228	16.7688	5.99	No	No	0	4	8
35	R:R:C232	R:R:Y228	16.8473	9.41	No	No	0	8	8
36	R:R:C232	R:R:P270	18.133	5.65	No	Yes	0	8	9
37	E:E:T130	R:R:P304	10.7132	6.99	No	No	6	9	9
38	L:L:?101	R:R:Y146	43.7764	11.3	Yes	No	8	0	2
39	L:L:?101	R:R:L151	45.7154	3.64	Yes	No	0	0	5
40	R:R:F382	R:R:L151	45.5365	3.65	No	No	0	7	5
41	R:R:F382	R:R:F386	45.7067	3.22	No	No	0	7	5
42	R:R:F386	R:R:P350	30.8953	4.33	No	No	0	5	9
43	R:R:P350	R:R:V349	30.8986	5.3	No	No	0	9	8
44	R:R:I354	R:R:V349	31.9564	7.68	Yes	No	0	6	8
45	R:R:I354	R:R:L352	24.4286	4.28	Yes	Yes	0	6	9
46	R:R:L352	R:R:N312	29.2465	8.24	Yes	No	0	9	9
47	R:R:L238	R:R:N312	28.8408	5.49	Yes	No	0	8	9
48	R:R:I242	R:R:L238	16.2203	7.14	Yes	Yes	0	7	8
49	E:E:V137	R:R:W261	11.1396	2.45	No	Yes	0	9	2
50	R:R:F315	R:R:I242	11.7176	3.77	No	Yes	0	8	7
51	R:R:F315	R:R:H245	17.1309	23.76	No	Yes	0	8	8
52	R:R:M230	R:R:Y234	36.675	4.79	Yes	Yes	0	6	7
53	R:R:Q355	R:R:V349	11.5398	2.87	Yes	No	0	8	8
54	R:R:F356	R:R:I380	16.5267	7.54	Yes	No	0	7	6
55	R:R:F356	R:R:Y234	10.0938	11.35	Yes	Yes	0	7	7
56	R:R:L202	R:R:V206	19.4624	2.98	Yes	No	0	7	3
57	R:R:H201	R:R:V206	17.8157	2.77	Yes	No	0	6	3
58	R:R:H201	R:R:L291	14.4962	2.57	Yes	Yes	0	6	6
59	L:L:?37	R:R:W79	15.3719	9.23	Yes	Yes	1	0	6
60	L:L:?37	R:R:S129	11.2497	6.08	Yes	Yes	1	0	7
61	R:R:K110	R:R:S129	11.2257	10.71	Yes	Yes	0	8	7
62	R:R:K110	R:R:W118	10.2824	15.08	Yes	Yes	0	8	9
63	R:R:F385	R:R:F386	19.578	4.29	Yes	No	0	5	5
64	R:R:M237	R:R:Y234	37.4853	3.59	Yes	Yes	0	9	7
65	R:R:F385	R:R:T162	10.157	7.78	Yes	No	0	5	6
66	R:R:C392	R:R:F393	15.0382	2.79	No	Yes	0	9	8
67	R:R:C392	R:R:F170	13.795	6.98	No	Yes	0	9	8
68	R:R:F170	R:R:V398	16.5049	2.62	Yes	No	0	8	9
69	R:R:L176	R:R:V398	13.4526	4.47	No	No	0	9	9
70	R:R:L176	R:R:T401	11.3948	2.95	No	Yes	9	9	7
71	R:R:M187	R:R:M237	21.0534	2.89	Yes	Yes	3	8	9
72	R:R:M187	R:R:T190	20.9586	3.01	Yes	Yes	3	8	9
73	R:R:T190	R:R:W236	29.9095	4.85	Yes	Yes	3	9	9
74	R:R:W236	R:R:Y263	10.3784	3.86	Yes	No	3	9	5
75	R:R:M237	R:R:N233	14.4929	2.8	Yes	No	3	9	9
76	R:R:N233	R:R:T190	19.3457	8.77	No	Yes	3	9	9
77	R:R:C232	R:R:W267	13.0316	5.22	No	No	0	8	9
78	R:R:L351	R:R:L352	10.5224	2.77	Yes	Yes	0	9	9
79	R:R:V387	R:R:Y191	13.5649	3.79	No	Yes	0	9	8
80	R:R:F188	R:R:V387	16.4995	5.24	Yes	No	0	8	9
81	R:R:C239	R:R:W236	19.4864	7.84	No	Yes	0	7	9
82	R:R:I354	R:R:L316	10.4122	7.14	Yes	No	0	6	9
83	R:R:C239	R:R:Y262	10.0872	5.38	No	Yes	0	7	7
84	R:R:F170	R:R:F188	12.6063	5.36	Yes	Yes	0	8	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
E:E:T73	E:E:W84	8.49	1	No	Yes	9	7	2	1
E:E:T73	E:E:V89	7.93	1	No	No	9	8	2	2
E:E:W74	E:E:W84	5.62	0	No	Yes	6	7	2	1
E:E:F83	R:R:N124	9.67	0	No	No	5	5	2	1
E:E:F83	R:R:R126	23.52	0	No	No	5	4	2	1
E:E:P85	E:E:W84	18.92	0	No	Yes	9	7	2	1
E:E:V89	E:E:W84	6.13	1	No	Yes	8	7	2	1
E:E:W84	L:L:?37	3.69	1	Yes	Yes	7	0	1	0
E:E:W84	R:R:Q52	4.38	1	Yes	Yes	7	6	1	2
E:E:P85	R:R:G78	4.06	0	No	No	9	5	2	1
L:L:A1	R:R:E294	4.53	0	No	No	0	3	0	1
L:L:C2	R:R:L298	4.76	2	Yes	No	0	6	0	1
L:L:C2	R:R:H302	4.42	2	Yes	Yes	0	6	0	1
L:L:D3	R:R:W361	10.05	0	No	No	0	4	0	1
L:L:T4	R:R:M306	4.52	2	Yes	No	0	4	0	1
L:L:A5	R:R:F356	4.16	0	No	Yes	0	7	0	1
L:L:T6	R:R:Y234	8.74	2	Yes	Yes	0	7	0	1
L:L:T6	R:R:H302	9.58	2	Yes	Yes	0	6	0	1
L:L:T6	R:R:M306	6.02	2	Yes	No	0	4	0	1
L:L:C7	R:R:H302	10.32	2	No	Yes	0	6	0	1
L:L:V8	R:R:H377	6.92	0	No	Yes	0	7	0	1
L:L:V8	R:R:I380	4.61	0	No	No	0	6	0	1
L:L:T9	R:R:I198	3.04	0	No	Yes	0	7	0	1
L:L:H10	R:R:H226	7.17	2	No	No	0	6	0	1
L:L:H10	R:R:M230	6.57	2	No	Yes	0	6	0	1
L:L:H10	R:R:H302	8.36	2	No	Yes	0	6	0	1
L:L:R11	R:R:V293	3.92	0	No	No	0	6	0	1
L:L:L12	R:R:L148	2.77	7	No	Yes	0	5	0	1
L:L:L12	R:R:H377	6.43	7	No	Yes	0	7	0	1
L:L:A13	R:R:H201	2.93	0	No	Yes	0	6	0	1
L:L:L15	R:R:K141	4.23	16	No	No	0	3	0	1
L:L:L15	R:R:L142	4.15	16	No	Yes	0	2	0	1
L:L:L16	R:R:A145	3.15	0	No	No	0	4	0	1
L:L:L16	R:R:Y149	3.52	0	No	Yes	0	5	0	1
L:L:S17	R:R:L291	4.5	0	No	Yes	0	6	0	1
L:L:R18	R:R:P104	5.76	0	No	No	0	3	0	1
L:L:S19	R:R:L142	6.01	16	No	Yes	0	2	0	1
L:L:V23	R:R:L142	4.47	0	No	Yes	0	2	0	1
L:L:V23	R:R:Y146	10.09	0	No	No	0	2	0	1
L:L:F27	R:R:D101	4.78	0	No	Yes	0	4	0	1
L:L:T30	R:R:F99	20.75	1	Yes	Yes	0	5	0	1
L:L:T30	R:R:D101	8.67	1	Yes	Yes	0	4	0	1
L:L:T30	R:R:F102	5.19	1	Yes	Yes	0	4	0	1
L:L:T30	R:R:N135	2.92	1	Yes	No	0	3	0	1
L:L:S34	R:R:H121	6.97	0	No	No	0	4	0	1
L:L:S34	R:R:E123	10.06	0	No	No	0	4	0	1
L:L:K35	R:R:N124	4.2	0	No	No	0	5	0	1
L:L:?37	R:R:D77	3.3	1	Yes	Yes	0	9	0	1
L:L:?37	R:R:G78	8.32	1	Yes	No	0	5	0	1
L:L:?37	R:R:W79	9.23	1	Yes	Yes	0	6	0	1
L:L:?37	R:R:R126	7.87	1	Yes	No	0	4	0	1
L:L:?37	R:R:W128	6.46	1	Yes	No	0	5	0	1
L:L:?37	R:R:S129	6.08	1	Yes	Yes	0	7	0	1
L:L:?37	R:R:Y131	3.8	1	Yes	Yes	0	5	0	1
L:L:?101	R:R:Y146	11.3	8	Yes	No	0	2	0	1
L:L:?101	R:R:Y150	10.28	8	Yes	No	0	4	0	1
L:L:?101	R:R:L151	3.64	8	Yes	No	0	5	0	1
L:L:?101	R:R:V154	3.92	8	Yes	No	0	6	0	1
R:R:M48	R:R:W79	5.82	1	No	Yes	6	6	2	1
R:R:M48	R:R:Y98	9.58	1	No	Yes	6	4	2	2
R:R:D77	R:R:G78	3.35	1	Yes	No	9	5	1	1
R:R:D77	R:R:L80	4.07	1	Yes	Yes	9	5	1	2
R:R:D77	R:R:W82	8.93	1	Yes	No	9	9	1	2
R:R:D77	R:R:S129	4.42	1	Yes	Yes	9	7	1	1
R:R:D77	R:R:Y131	5.75	1	Yes	Yes	9	5	1	1
R:R:W79	R:R:Y98	5.79	1	Yes	Yes	6	4	1	2
R:R:F99	R:R:W79	9.02	1	Yes	Yes	5	6	1	1
R:R:F102	R:R:W79	7.02	1	Yes	Yes	4	6	1	1
R:R:W79	R:R:Y131	19.29	1	Yes	Yes	6	5	1	1
R:R:L80	R:R:P96	11.49	1	Yes	Yes	5	9	2	2
R:R:L80	R:R:V108	4.47	1	Yes	No	5	7	2	2
R:R:L80	R:R:Y131	5.86	1	Yes	Yes	5	5	2	1
R:R:K110	R:R:W82	19.73	0	Yes	No	8	9	2	2
R:R:C95	R:R:P96	3.77	1	No	Yes	9	9	2	2
R:R:C95	R:R:F102	6.98	1	No	Yes	9	4	2	1
R:R:C134	R:R:C95	7.28	1	No	No	9	9	2	2
R:R:P96	R:R:Y98	13.91	1	Yes	Yes	9	4	2	2
R:R:F102	R:R:P96	2.89	1	Yes	Yes	4	9	1	2
R:R:F99	R:R:Y98	3.09	1	Yes	Yes	5	4	1	2
R:R:D101	R:R:F99	3.58	1	Yes	Yes	4	5	1	1
R:R:F102	R:R:F99	12.86	1	Yes	Yes	4	5	1	1
R:R:D101	R:R:N135	12.12	1	Yes	No	4	3	1	1
R:R:C134	R:R:F102	5.59	1	No	Yes	9	4	2	1
R:R:F102	R:R:N135	7.25	1	Yes	No	4	3	1	1
R:R:D103	R:R:P104	6.44	5	Yes	No	3	3	2	1
R:R:D103	R:R:K141	2.77	5	Yes	No	3	3	2	1
R:R:V108	R:R:Y131	10.09	1	No	Yes	7	5	2	1
R:R:K110	R:R:S129	10.71	0	Yes	Yes	8	7	2	1
R:R:H121	R:R:P122	10.68	0	No	No	4	5	1	2
R:R:H121	R:R:W128	19.04	0	No	No	4	5	1	1
R:R:E123	R:R:N124	13.15	0	No	No	4	5	1	1
R:R:N130	R:R:W128	7.91	5	Yes	No	8	5	2	1
R:R:S129	R:R:Y131	5.09	1	Yes	Yes	7	5	1	1
R:R:Y146	R:R:Y150	3.97	8	No	No	2	4	1	1
R:R:D373	R:R:L148	5.43	0	No	Yes	5	5	2	1
R:R:L148	R:R:Y374	4.69	7	Yes	Yes	5	6	1	2
R:R:H377	R:R:L148	18	7	Yes	Yes	7	5	1	1
R:R:Y149	R:R:Y150	11.91	8	Yes	No	5	4	1	1
R:R:I153	R:R:Y149	8.46	8	No	Yes	7	5	2	1
R:R:L202	R:R:Y149	4.69	8	Yes	Yes	7	5	2	1
R:R:L151	R:R:S378	6.01	0	No	No	5	5	1	2
R:R:F382	R:R:L151	3.65	0	No	No	7	5	2	1
R:R:I153	R:R:L202	2.85	8	No	Yes	7	7	2	2
R:R:H156	R:R:I198	11.93	0	Yes	Yes	7	7	2	1
R:R:H156	R:R:H381	10.75	0	Yes	No	7	9	2	2
R:R:I198	R:R:N194	5.66	0	Yes	No	7	8	1	2
R:R:M230	R:R:N194	2.8	2	Yes	No	6	8	1	2
R:R:H226	R:R:I197	5.3	0	No	No	6	5	1	2
R:R:I198	R:R:L202	2.85	0	Yes	Yes	7	7	1	2
R:R:H226	R:R:I198	3.98	0	No	Yes	6	7	1	1
R:R:H201	R:R:V205	11.07	0	Yes	No	6	7	1	2
R:R:H201	R:R:V206	2.77	0	Yes	No	6	3	1	2
R:R:L202	R:R:V206	2.98	8	Yes	No	7	3	2	2
R:R:C289	R:R:V212	6.83	17	No	Yes	9	3	2	2
R:R:L291	R:R:V212	2.98	17	Yes	Yes	6	3	1	2
R:R:M230	R:R:Q227	2.72	2	Yes	Yes	6	7	1	2
R:R:H277	R:R:Q227	9.89	2	Yes	Yes	7	7	2	2
R:R:M230	R:R:Y234	4.79	2	Yes	Yes	6	7	1	1
R:R:H302	R:R:M230	7.88	2	Yes	Yes	6	6	1	1
R:R:M237	R:R:Y234	3.59	3	Yes	Yes	9	7	2	1
R:R:V305	R:R:Y234	7.57	0	No	Yes	7	7	2	1
R:R:F356	R:R:Y234	11.35	3	Yes	Yes	7	7	1	1
R:R:M237	R:R:Q383	5.44	3	Yes	Yes	9	9	2	2
R:R:H277	R:R:L298	3.86	2	Yes	No	7	6	2	1
R:R:C289	R:R:L291	4.76	17	No	Yes	9	6	2	1
R:R:E294	R:R:S292	2.87	0	No	No	3	4	1	2
R:R:E294	R:R:V293	2.85	0	No	No	3	6	1	1
R:R:L298	R:R:V293	2.98	0	No	No	6	6	1	1
R:R:F356	R:R:L309	3.65	3	Yes	No	7	7	1	2
R:R:G353	R:R:Q355	4.93	3	No	Yes	9	8	2	2
R:R:F356	R:R:G353	3.01	3	Yes	No	7	9	1	2
R:R:F356	R:R:Q355	9.37	3	Yes	Yes	7	8	1	2
R:R:Q355	R:R:Q383	8.96	3	Yes	Yes	8	9	2	2
R:R:F356	R:R:I380	7.54	3	Yes	No	7	6	1	1
R:R:F356	R:R:Q383	4.68	3	Yes	Yes	7	9	1	2
R:R:I380	R:R:M376	2.92	0	No	No	6	7	1	2
R:R:H377	R:R:H381	9.55	7	Yes	No	7	9	1	2
L:L:C2	R:R:Y299	2.69	2	Yes	No	0	7	0	1
L:L:V32	R:R:F102	2.62	0	No	Yes	0	4	0	1
R:R:H201	R:R:L291	2.57	0	Yes	Yes	6	6	1	1
R:R:V203	R:R:Y149	2.52	0	No	Yes	3	5	2	1
L:L:T4	R:R:W361	2.43	2	Yes	No	0	4	0	1
E:E:I123	R:R:Y299	2.42	0	No	No	9	7	2	1
L:L:V22	R:R:P100	1.77	0	No	No	0	4	0	1
R:R:M306	R:R:P360	1.68	2	No	No	4	5	1	2
L:L:P29	R:R:D101	1.61	0	No	Yes	0	4	0	1
R:R:L142	R:R:T138	1.47	16	Yes	No	2	2	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9AUC_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.71
Number of Linked Nodes	495
Number of Links	626
Number of Hubs	114
Number of Links mediated by Hubs	405
Number of Communities	18
Number of Nodes involved in Communities	173
Number of Links involved in Communities	252

Path Summary
Number Of Nodes in MetaPath	85
Number Of Links MetaPath	84
Number of Shortest Paths	211638
Length Of Smallest Path	3
Average Path Length	17.6941
Length of Longest Path	41
Minimum Path Strength	1.41
Average Path Strength	5.83636
Maximum Path Strength	19.72
Minimum Path Correlation	0.7
Average Path Correlation	0.964489
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.33333
Average % Of Corr. Nodes	60.7232
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	51.7466
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • molecular function activator activity • phosphorus-oxygen lyase activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • adenylate cyclase activator activity • adenylate cyclase activity • cation binding • metal ion binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • biological regulation • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of biological process • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • protein localization • regulation of localization • establishment of protein localization • nitrogen compound transport • localization • cellular macromolecule localization • regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • protein transport • regulation of cellular localization • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • calcitonin family binding • calcitonin gene-related peptide binding • amide binding • peptide hormone binding • hormone binding • molecular transducer activity • coreceptor activity • signaling receptor activity • calcitonin family receptor activity • peptide receptor activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • transmembrane signaling receptor activity • calcitonin gene-related peptide receptor activity • amylin receptor activity • protein localization • cellular localization • establishment of protein localization • nitrogen compound transport • transport • intracellular transport • establishment of localization • localization • protein transport • establishment of localization in cell • cellular macromolecule localization • macromolecule localization • intracellular protein transport • regulation of signaling • regulation of signal transduction • regulation of response to stimulus • regulation of cell communication • regulation of G protein-coupled receptor signaling pathway • import into cell • receptor internalization • receptor-mediated endocytosis • endocytosis • vesicle-mediated transport • blood vessel morphogenesis • tube development • angiogenesis • vasculature development • circulatory system development • anatomical structure morphogenesis • tube morphogenesis • anatomical structure formation involved in morphogenesis • blood vessel development • calcitonin family receptor signaling pathway • calcitonin gene-related peptide receptor signaling pathway • regulation of protein modification process • positive regulation of glycoprotein metabolic process • positive regulation of protein metabolic process • positive regulation of biological process • carbohydrate derivative metabolic process • positive regulation of macromolecule biosynthetic process • positive regulation of protein glycosylation • regulation of primary metabolic process • positive regulation of metabolic process • positive regulation of protein modification process • positive regulation of biosynthetic process • positive regulation of macromolecule metabolic process • protein metabolic process • protein modification process • positive regulation of cellular process • regulation of glycoprotein biosynthetic process • positive regulation of glycoprotein biosynthetic process • carbohydrate derivative biosynthetic process • regulation of biosynthetic process • regulation of protein metabolic process • glycoprotein biosynthetic process • primary metabolic process • regulation of macromolecule metabolic process • glycoprotein metabolic process • macromolecule biosynthetic process • protein glycosylation • regulation of glycoprotein metabolic process • biosynthetic process • glycosylation • macromolecule modification • macromolecule glycosylation • regulation of protein glycosylation • metabolic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • regulation of metabolic process • amylin receptor signaling pathway • monoatomic ion transport • monoatomic cation transport • calcium ion transport • metal ion transport • protein localization to cell periphery • protein localization to plasma membrane • localization within membrane • protein localization to membrane • amylin receptor 1 signaling pathway • receptor complex • cell surface • plasma membrane signaling receptor complex • G protein-coupled receptor complex • CGRP receptor complex • calcitonin family receptor complex • signaling receptor binding • molecular function activator activity • signaling receptor activator activity • hormone activity • molecular function regulator activity • signaling receptor regulator activity • receptor ligand activity • endothelial cell proliferation • epithelial cell proliferation • circulatory system process • regulation of blood pressure • regulation of biological quality • blood circulation • interleukin-1 production • positive regulation of interleukin-1 alpha production • regulation of cytokine production • cytokine production • regulation of multicellular organismal process • positive regulation of interleukin-1 production • regulation of interleukin-1 production • gene expression • regulation of interleukin-1 alpha production • regulation of gene expression • interleukin-1 alpha production • positive regulation of gene expression • positive regulation of multicellular organismal process • positive regulation of cytokine production • endothelial cell migration • cell migration • cell motility • myeloid leukocyte differentiation • regulation of leukocyte differentiation • cellular developmental process • regulation of developmental process • negative regulation of biological process • cell development • regulation of cell differentiation • regulation of cell development • regulation of osteoclast differentiation • cell differentiation • osteoclast differentiation • negative regulation of cellular process • regulation of immune system process • negative regulation of cell differentiation • negative regulation of hemopoiesis • regulation of multicellular organismal development • negative regulation of leukocyte differentiation • hemopoiesis • regulation of myeloid cell differentiation • negative regulation of developmental process • regulation of myeloid leukocyte differentiation • negative regulation of myeloid cell differentiation • negative regulation of osteoclast differentiation • negative regulation of myeloid leukocyte differentiation • negative regulation of cell development • myeloid cell differentiation • negative regulation of immune system process • immune system process • regulation of hemopoiesis • negative regulation of multicellular organismal process • leukocyte differentiation • inorganic ion homeostasis • intracellular calcium ion homeostasis • homeostatic process • calcium ion homeostasis • regulation of cytosolic calcium ion concentration • cellular homeostasis • chemical homeostasis • intracellular monoatomic cation homeostasis • monoatomic ion homeostasis • intracellular chemical homeostasis • monoatomic cation homeostasis • intracellular monoatomic ion homeostasis • positive regulation of interleukin-8 production • interleukin-8 production • regulation of interleukin-8 production • regulation of tube diameter • regulation of tube size • vascular process in circulatory system • blood vessel diameter maintenance • vasodilation • regulation of anatomical structure size • negative regulation of tissue remodeling • negative regulation of bone remodeling • regulation of bone remodeling • tissue homeostasis • regulation of tissue remodeling • regulation of bone resorption • bone resorption • negative regulation of bone resorption • multicellular organismal-level homeostasis • tissue remodeling • bone remodeling • anatomical structure homeostasis • protein phosphorylation • phosphorylation • phosphate-containing compound metabolic process • phosphorus metabolic process • cell adhesion • cell-cell adhesion • leukocyte cell-cell adhesion • mononuclear cell differentiation • positive regulation of developmental process • positive regulation of cell differentiation • positive regulation of hemopoiesis • regulation of macrophage differentiation • positive regulation of immune system process • positive regulation of cell development • macrophage differentiation • positive regulation of myeloid leukocyte differentiation • positive regulation of macrophage differentiation • positive regulation of myeloid cell differentiation • positive regulation of leukocyte differentiation • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • regulation of systemic arterial blood pressure • nervous system process involved in regulation of systemic arterial blood pressure • regulation of localization • regulation of calcium ion transport • regulation of calcium ion transport into cytosol • monoatomic ion transmembrane transport • negative regulation of monoatomic ion transport • negative regulation of transport • regulation of monoatomic ion transmembrane transport • negative regulation of transmembrane transport • regulation of calcium ion transmembrane transport • monoatomic cation transmembrane transport • negative regulation of monoatomic ion transmembrane transport • negative regulation of cation transmembrane transport • negative regulation of calcium ion transport into cytosol • regulation of metal ion transport • calcium ion transmembrane import into cytosol • regulation of transport • regulation of monoatomic ion transport • positive regulation of cytosolic calcium ion concentration • inorganic ion transmembrane transport • inorganic cation transmembrane transport • negative regulation of calcium ion transport • transmembrane transport • regulation of transmembrane transport • regulation of cellular localization • regulation of monoatomic cation transmembrane transport • negative regulation of calcium ion transmembrane transport • negative regulation of cytosolic calcium ion concentration • calcium ion transmembrane transport • calcium ion transport into cytosol • negative adaptation of signaling pathway • negative regulation of signaling • desensitization of G protein-coupled receptor signaling pathway • negative regulation of G protein-coupled receptor signaling pathway • negative regulation of cell communication • G protein-coupled receptor internalization • negative regulation of response to stimulus • negative regulation of signal transduction • adaptation of signaling pathway • negative regulation of blood pressure • amyloid-beta binding • peptide binding • calcitonin receptor activity • calcitonin binding • positive regulation of cell communication • positive regulation of signal transduction • positive regulation of response to stimulus • regulation of intracellular signal transduction • regulation of calcium-mediated signaling • positive regulation of calcium-mediated signaling • positive regulation of intracellular signal transduction • calcium-mediated signaling • positive regulation of signaling • catabolic process • RNA metabolic process • macromolecule catabolic process • nucleobase-containing compound metabolic process • post-transcriptional regulation of gene expression • regulation of RNA metabolic process • regulation of mRNA catabolic process • regulation of nucleobase-containing compound metabolic process • RNA catabolic process • negative regulation of macromolecule metabolic process • mRNA catabolic process • negative regulation of metabolic process • regulation of catabolic process • mRNA metabolic process • nucleic acid metabolic process • nucleobase-containing compound catabolic process • regulation of mRNA stability • negative regulation of gene expression • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • regulation of RNA stability • nucleic acid catabolic process • regulation of mRNA metabolic process • positive regulation of ERK1 and ERK2 cascade • positive regulation of MAPK cascade • regulation of MAPK cascade • MAPK cascade • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • phosphatidylinositol 3-kinase/protein kinase B signal transduction • response to corticosteroid • response to steroid hormone • response to glucocorticoid • response to amyloid-beta • cell surface receptor signaling pathway • ossification • amylin receptor 2 signaling pathway • positive regulation of cAMP/PKA signal transduction • cAMP/PKA signal transduction • regulation of cAMP/PKA signal transduction • regulation of ossification • negative regulation of ossification • amylin receptor 3 signaling pathway • amylin receptor complex • amylin receptor complex 3 • amylin receptor complex 2 • amylin receptor complex 1 • axon • acrosomal vesicle • intracellular vesicle • cytoplasmic vesicle • secretory granule • secretory vesicle
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • RAMP1-like • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • RAMP1-like • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	NFA
PDB Residues	L:L:?37
Environment Details	Open EMBL-EBI Page
Code	NFA
Name	Phenylalanylamide
Synonyms	Phenylalanylamide Phenylalanine amide (S)-2-amino-3-phenylpropanamide Phenylalaninamide L-phenylalanine amide
Identifier
Formula	C9 H12 N2 O
Molecular Weight	164.204
SMILES
PubChem	445694
Formal Charge	0
Total Atoms	24
Total Chiral Atoms	1
Total Bonds	24
Total Aromatic Bonds	6


Code	PLM
PDB Residues	L:L:?101
Environment Details	Open EMBL-EBI Page
Code	PLM
Name	Palmitic Acid
Synonyms	Hexadecylic acid
Identifier
Formula	C16 H32 O2
Molecular Weight	256.424
SMILES
PubChem	985
Formal Charge	0
Total Atoms	50
Total Chiral Atoms	0
Total Bonds	49
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	E
Protein	RAMP1
UniProt	O60894
Sequence	>9AUC_nogp_Chain_E C Q E A N Y G A L L R E L C L T Q F Q V D M E A V G E T L W C D W G R T I R S Y R E L A D C T W H M A E K L G C F W P N A E V D R F F L A V H G R Y F R S C P I S G R A V R D P P G S I L Y P F I V V P I T V T L L V T A L V V W Q S K R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	R
Protein	Receptor
UniProt	P30988
Sequence	>9AUC_nogp_Chain_R V V G R K K M M D A Q Y K C Y D R M Q Q L P A Y Q G E G P Y C N R T W D G W L C W D D T P A G V L S Y Q F C P D Y F P D F D P S E K V T K Y C D E K G V W F K H P E N N R T W S N Y T M C N A F T P E K L K N A Y V L Y Y L A I V G H S L S I F T L V I S L G I F V F F R S L G C Q R V T L H K N M F L T Y I L N S M I I I I H L V E V V P N G E L V R R D P V S C K I L H F F H Q Y M M A C N Y F W M L C E G I Y L H T L I V V A V F T E K Q R L R W Y Y L L G W G F P L V P T T I H A I T R A V Y F N D N C W L S V E T H L L Y I I H G P V M A A L V V N F F F L L N I V R V L V T K M R E T H E A E S H M Y L K A V K A T M I L V P L L G I Q F V V F P W R P S N K M L G K I Y D Y V M H S L I H F Q G F F V A T I Y C F C N N E V Q T T V K R Q W A Q F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9AUC	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Calcitonin gene-related peptide-1	-	Gs/β1/γ2; RAMP1	2.4	2024-04-24	10.1021/acs.biochem.4c00114
	9AUC (No Gprot)	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Calcitonin gene-related peptide-1	-		2.4	2024-04-24	10.1021/acs.biochem.4c00114
	7TYW	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Calcitonin-1	-	Gs/β1/γ2; RAMP1	3	2022-03-23	10.1126/science.abm9609
	7TYW (No Gprot)	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Calcitonin-1	-		3	2022-03-23	10.1126/science.abm9609
	7TYF	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Amylin	-	Gs/β1/γ2; RAMP1	2.2	2022-03-23	10.1126/science.abm9609
	7TYF (No Gprot)	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Amylin	-		2.2	2022-03-23	10.1126/science.abm9609

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