CodeNFA
NamePhenylalanylamide
Synonyms
  • Phenylalanylamide
  • Phenylalaninamide
  • Phenylalanine amide
  • L-phenylalanine amide
  • (S)-2-amino-3-phenylpropanamide
Identifier(2S)-2-amino-3-phenyl-propanamide
FormulaC9 H12 N2 O
Molecular Weight164.204
SMILESc1ccc(cc1)C[C@@H](C(=O)N)N
PubChem445694
Formal Charge0
Total Atoms24
Total Chiral Atoms1
Total Bonds24
Total Aromatic Bonds6
Networks3
 missing image

This ligand is also present in the following 3 networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7F8V A Peptide Cholecystokinin CCKB Homo sapiens Gastrin-17 - Gi2/Beta1/Gamma2 3.3 2021-10-13 10.1038/s41589-021-00866-8

A 2D representation of the interactions of NFA in 7F8V
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?17 L:L:D16 4.34 1 Yes Yes 0 0 0 1
L:L:D16 R:R:Y189 11.49 1 Yes Yes 0 7 1 2
L:L:D16 R:R:H207 6.3 1 Yes Yes 0 5 1 2
L:L:D16 R:R:N353 16.16 1 Yes No 0 7 1 2
L:L:D16 R:R:R356 4.76 1 Yes Yes 0 4 1 2
L:L:?17 R:R:T111 3.54 1 Yes No 0 7 0 1
L:L:?17 R:R:M134 4.52 1 Yes No 0 8 0 1
L:L:?17 R:R:V138 17.87 1 Yes No 0 7 0 1
L:L:?17 R:R:L222 5.53 1 Yes Yes 0 7 0 1
L:L:?17 R:R:Y350 7.5 1 Yes Yes 0 7 0 1
L:L:?17 R:R:H376 10.28 1 Yes Yes 0 5 0 1
L:L:?17 R:R:Y380 4.69 1 Yes Yes 0 7 0 1
R:R:M108 R:R:Y61 4.79 1 Yes Yes 7 7 2 2
R:R:Y380 R:R:Y61 5.96 1 Yes Yes 7 7 1 2
R:R:C107 R:R:M134 6.48 0 No No 7 8 2 1
R:R:C107 R:R:Y380 10.75 0 No Yes 7 7 2 1
R:R:M108 R:R:Y380 7.18 1 Yes Yes 7 7 2 1
R:R:T111 R:R:Y380 3.75 1 No Yes 7 7 1 1
R:R:V138 R:R:W346 4.9 0 No Yes 7 8 1 2
R:R:H207 R:R:Y189 14.16 1 Yes Yes 5 7 2 2
R:R:W218 R:R:Y189 4.82 0 No Yes 7 7 2 2
R:R:L222 R:R:W218 3.42 1 Yes No 7 7 1 2
R:R:L222 R:R:L226 5.54 1 Yes Yes 7 8 1 2
R:R:L222 R:R:Y350 3.52 1 Yes Yes 7 7 1 1
R:R:L223 R:R:Y350 3.52 0 No Yes 7 7 2 1
R:R:L226 R:R:Y350 5.86 1 Yes Yes 8 7 2 1
R:R:F227 R:R:Y350 12.38 1 Yes Yes 8 7 2 1
R:R:W346 R:R:Y350 7.72 0 Yes Yes 8 7 2 1
R:R:S379 R:R:W346 11.12 0 No Yes 7 8 2 2
R:R:H376 R:R:V349 5.54 1 Yes No 5 7 1 2
R:R:S379 R:R:V349 3.23 0 No No 7 7 2 2
R:R:H376 R:R:I372 5.3 1 Yes No 5 4 1 2
R:R:H376 R:R:Y380 7.62 1 Yes Yes 5 7 1 1
R:R:S379 R:R:Y380 5.09 0 No Yes 7 7 2 1
StatisticsValue
Average Number Of Links8.00
Average Number Of Links With An Hub5.00
Average Interaction Strength7.28
Average Nodes In Shell24.00
Average Hubs In Shell14.00
Average Links In Shell34.00
Average Links Mediated by Hubs In Shell32.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7F8W A Peptide Cholecystokinin CCKB Homo sapiens Gastrin-17 - chim(NtGsL-Gq)/Beta1/Gamma2 3.1 2021-10-13 10.1038/s41589-021-00866-8

A 2D representation of the interactions of NFA in 7F8W
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?17 L:L:D16 7.6 4 Yes Yes 0 0 0 1
L:L:D16 R:R:Y189 6.9 4 Yes Yes 0 7 1 2
L:L:D16 R:R:N353 13.46 4 Yes No 0 7 1 2
L:L:D16 R:R:R356 9.53 4 Yes Yes 0 4 1 2
L:L:?17 R:R:T111 3.54 4 Yes No 0 7 0 1
L:L:?17 R:R:M134 7.91 4 Yes Yes 0 8 0 1
L:L:?17 R:R:V138 19.06 4 Yes No 0 7 0 1
L:L:?17 R:R:Y380 3.75 4 Yes Yes 0 7 0 1
R:R:Y380 R:R:Y61 5.96 4 Yes Yes 7 7 1 2
R:R:C107 R:R:M134 6.48 0 No Yes 7 8 2 1
R:R:C107 R:R:Y380 4.03 0 No Yes 7 7 2 1
R:R:M108 R:R:Y380 5.99 0 No Yes 7 7 2 1
R:R:T111 R:R:Y380 3.75 4 No Yes 7 7 1 1
R:R:M134 R:R:V130 3.04 0 Yes No 8 6 1 2
R:R:V138 R:R:W346 6.13 0 No Yes 7 8 1 2
R:R:N353 R:R:R356 6.03 4 No Yes 7 4 2 2
R:R:H376 R:R:Y380 4.36 0 No Yes 5 7 2 1
R:R:A106 R:R:M134 1.61 0 No Yes 5 8 2 1
StatisticsValue
Average Number Of Links5.00
Average Number Of Links With An Hub3.00
Average Interaction Strength8.37
Average Nodes In Shell16.00
Average Hubs In Shell8.00
Average Links In Shell18.00
Average Links Mediated by Hubs In Shell18.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9AUC B1 Peptide Calcitonin CT Homo Sapiens Calcitonin gene-related peptide-1 - Gs/Beta1/Gamma2; RAMP1 2.4 2024-04-24 10.1021/acs.biochem.4c00114

A 2D representation of the interactions of NFA in 9AUC
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
E:E:T73 E:E:W84 8.49 1 No Yes 9 9 2 1
E:E:T73 E:E:V89 7.93 1 No No 9 9 2 2
E:E:W74 E:E:W84 5.62 0 No Yes 1 9 2 1
E:E:F83 R:R:R126 23.52 0 No No 5 4 2 1
E:E:P85 E:E:W84 18.92 0 No Yes 9 9 2 1
E:E:V89 E:E:W84 6.13 1 No Yes 9 9 2 1
E:E:W84 L:L:?37 3.64 1 Yes Yes 9 0 1 0
E:E:W84 R:R:Q52 4.38 1 Yes Yes 9 6 1 2
E:E:P85 R:R:G78 4.06 0 No No 9 5 2 1
L:L:?37 L:L:A36 3.78 1 Yes No 0 0 0 1
L:L:?37 R:R:D77 3.26 1 Yes Yes 0 9 0 1
L:L:?37 R:R:G78 8.21 1 Yes No 0 5 0 1
L:L:?37 R:R:W79 9.11 1 Yes Yes 0 6 0 1
L:L:?37 R:R:R126 7.77 1 Yes No 0 4 0 1
L:L:?37 R:R:W128 6.38 1 Yes Yes 0 5 0 1
L:L:?37 R:R:S129 6 1 Yes Yes 0 7 0 1
L:L:?37 R:R:Y131 3.75 1 Yes Yes 0 5 0 1
R:R:M48 R:R:W79 5.82 1 No Yes 6 6 2 1
R:R:M48 R:R:Y98 9.58 1 No Yes 6 4 2 2
R:R:D77 R:R:G78 3.35 1 Yes No 9 5 1 1
R:R:D77 R:R:L80 4.07 1 Yes Yes 9 5 1 2
R:R:D77 R:R:W82 8.93 1 Yes No 9 9 1 2
R:R:D77 R:R:S129 4.42 1 Yes Yes 9 7 1 1
R:R:D77 R:R:Y131 5.75 1 Yes Yes 9 5 1 1
R:R:W79 R:R:Y98 5.79 1 Yes Yes 6 4 1 2
R:R:F99 R:R:W79 9.02 1 Yes Yes 5 6 2 1
R:R:F102 R:R:W79 7.02 1 Yes Yes 4 6 2 1
R:R:W79 R:R:Y131 19.29 1 Yes Yes 6 5 1 1
R:R:L80 R:R:V108 4.47 1 Yes No 5 7 2 2
R:R:L80 R:R:Y131 5.86 1 Yes Yes 5 5 2 1
R:R:K110 R:R:W82 19.73 0 Yes No 8 9 2 2
R:R:F102 R:R:F99 12.86 1 Yes Yes 4 5 2 2
R:R:V108 R:R:Y131 10.09 1 No Yes 7 5 2 1
R:R:K110 R:R:S129 10.71 0 Yes Yes 8 7 2 1
R:R:H121 R:R:W128 19.04 0 No Yes 4 5 2 1
R:R:N130 R:R:W128 7.91 1 Yes Yes 8 5 2 1
H:H:?4 R:R:W128 7.11 1 Yes Yes 0 5 2 1
R:R:S129 R:R:Y131 5.09 1 Yes Yes 7 5 1 1
H:H:?4 R:R:N130 28.17 1 Yes Yes 0 8 2 2
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub6.00
Average Interaction Strength5.77
Average Nodes In Shell27.00
Average Hubs In Shell15.00
Average Links In Shell39.00
Average Links Mediated by Hubs In Shell36.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links7.33
Average Number Of Links With An Hub4.67
Average Interaction Strength7.14
Average Nodes In Shell22.33
Average Hubs In Shell12.33
Average Links In Shell30.33
Average Links Mediated by Hubs In Shell28.67

missing image


Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

missing image


Location of the nodes interacting with this ligand

(Click to enlarge 🔍)