Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7F8V | A | Peptide | Cholecystokinin | CCKB | Homo sapiens | Gastrin-17 | - | Gi2/Beta1/Gamma2 | 3.3 | 2021-10-13 | 10.1038/s41589-021-00866-8 |
![](/psngpcr/ligands/NFA/NFA_7F8V_L_L_17.png)
A 2D representation of the interactions of NFA in 7F8V colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | L:L:?17 | L:L:D16 | 4.34 | 1 | Yes | Yes | 0 | 0 | 0 | 1 | L:L:D16 | R:R:Y189 | 11.49 | 1 | Yes | Yes | 0 | 7 | 1 | 2 | L:L:D16 | R:R:H207 | 6.3 | 1 | Yes | Yes | 0 | 5 | 1 | 2 | L:L:D16 | R:R:N353 | 16.16 | 1 | Yes | No | 0 | 7 | 1 | 2 | L:L:D16 | R:R:R356 | 4.76 | 1 | Yes | Yes | 0 | 4 | 1 | 2 | L:L:?17 | R:R:T111 | 3.54 | 1 | Yes | No | 0 | 7 | 0 | 1 | L:L:?17 | R:R:M134 | 4.52 | 1 | Yes | No | 0 | 8 | 0 | 1 | L:L:?17 | R:R:V138 | 17.87 | 1 | Yes | No | 0 | 7 | 0 | 1 | L:L:?17 | R:R:L222 | 5.53 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | L:L:?17 | R:R:Y350 | 7.5 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | L:L:?17 | R:R:H376 | 10.28 | 1 | Yes | Yes | 0 | 5 | 0 | 1 | L:L:?17 | R:R:Y380 | 4.69 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:M108 | R:R:Y61 | 4.79 | 1 | Yes | Yes | 7 | 7 | 2 | 2 | R:R:Y380 | R:R:Y61 | 5.96 | 1 | Yes | Yes | 7 | 7 | 1 | 2 | R:R:C107 | R:R:M134 | 6.48 | 0 | No | No | 7 | 8 | 2 | 1 | R:R:C107 | R:R:Y380 | 10.75 | 0 | No | Yes | 7 | 7 | 2 | 1 | R:R:M108 | R:R:Y380 | 7.18 | 1 | Yes | Yes | 7 | 7 | 2 | 1 | R:R:T111 | R:R:Y380 | 3.75 | 1 | No | Yes | 7 | 7 | 1 | 1 | R:R:V138 | R:R:W346 | 4.9 | 0 | No | Yes | 7 | 8 | 1 | 2 | R:R:H207 | R:R:Y189 | 14.16 | 1 | Yes | Yes | 5 | 7 | 2 | 2 | R:R:W218 | R:R:Y189 | 4.82 | 0 | No | Yes | 7 | 7 | 2 | 2 | R:R:L222 | R:R:W218 | 3.42 | 1 | Yes | No | 7 | 7 | 1 | 2 | R:R:L222 | R:R:L226 | 5.54 | 1 | Yes | Yes | 7 | 8 | 1 | 2 | R:R:L222 | R:R:Y350 | 3.52 | 1 | Yes | Yes | 7 | 7 | 1 | 1 | R:R:L223 | R:R:Y350 | 3.52 | 0 | No | Yes | 7 | 7 | 2 | 1 | R:R:L226 | R:R:Y350 | 5.86 | 1 | Yes | Yes | 8 | 7 | 2 | 1 | R:R:F227 | R:R:Y350 | 12.38 | 1 | Yes | Yes | 8 | 7 | 2 | 1 | R:R:W346 | R:R:Y350 | 7.72 | 0 | Yes | Yes | 8 | 7 | 2 | 1 | R:R:S379 | R:R:W346 | 11.12 | 0 | No | Yes | 7 | 8 | 2 | 2 | R:R:H376 | R:R:V349 | 5.54 | 1 | Yes | No | 5 | 7 | 1 | 2 | R:R:S379 | R:R:V349 | 3.23 | 0 | No | No | 7 | 7 | 2 | 2 | R:R:H376 | R:R:I372 | 5.3 | 1 | Yes | No | 5 | 4 | 1 | 2 | R:R:H376 | R:R:Y380 | 7.62 | 1 | Yes | Yes | 5 | 7 | 1 | 1 | R:R:S379 | R:R:Y380 | 5.09 | 0 | No | Yes | 7 | 7 | 2 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 8.00 | Average Number Of Links With An Hub | 5.00 | Average Interaction Strength | 7.28 | Average Nodes In Shell | 24.00 | Average Hubs In Shell | 14.00 | Average Links In Shell | 34.00 | Average Links Mediated by Hubs In Shell | 32.00 |
| ![](/psngpcr/ligands/NFA/NFA_7F8V_L_L_17_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/NFA/NFA_7F8V_L_L_17_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7F8W | A | Peptide | Cholecystokinin | CCKB | Homo sapiens | Gastrin-17 | - | chim(NtGsL-Gq)/Beta1/Gamma2 | 3.1 | 2021-10-13 | 10.1038/s41589-021-00866-8 |
![](/psngpcr/ligands/NFA/NFA_7F8W_L_L_17.png)
A 2D representation of the interactions of NFA in 7F8W colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | L:L:?17 | L:L:D16 | 7.6 | 4 | Yes | Yes | 0 | 0 | 0 | 1 | L:L:D16 | R:R:Y189 | 6.9 | 4 | Yes | Yes | 0 | 7 | 1 | 2 | L:L:D16 | R:R:N353 | 13.46 | 4 | Yes | No | 0 | 7 | 1 | 2 | L:L:D16 | R:R:R356 | 9.53 | 4 | Yes | Yes | 0 | 4 | 1 | 2 | L:L:?17 | R:R:T111 | 3.54 | 4 | Yes | No | 0 | 7 | 0 | 1 | L:L:?17 | R:R:M134 | 7.91 | 4 | Yes | Yes | 0 | 8 | 0 | 1 | L:L:?17 | R:R:V138 | 19.06 | 4 | Yes | No | 0 | 7 | 0 | 1 | L:L:?17 | R:R:Y380 | 3.75 | 4 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:Y380 | R:R:Y61 | 5.96 | 4 | Yes | Yes | 7 | 7 | 1 | 2 | R:R:C107 | R:R:M134 | 6.48 | 0 | No | Yes | 7 | 8 | 2 | 1 | R:R:C107 | R:R:Y380 | 4.03 | 0 | No | Yes | 7 | 7 | 2 | 1 | R:R:M108 | R:R:Y380 | 5.99 | 0 | No | Yes | 7 | 7 | 2 | 1 | R:R:T111 | R:R:Y380 | 3.75 | 4 | No | Yes | 7 | 7 | 1 | 1 | R:R:M134 | R:R:V130 | 3.04 | 0 | Yes | No | 8 | 6 | 1 | 2 | R:R:V138 | R:R:W346 | 6.13 | 0 | No | Yes | 7 | 8 | 1 | 2 | R:R:N353 | R:R:R356 | 6.03 | 4 | No | Yes | 7 | 4 | 2 | 2 | R:R:H376 | R:R:Y380 | 4.36 | 0 | No | Yes | 5 | 7 | 2 | 1 | R:R:A106 | R:R:M134 | 1.61 | 0 | No | Yes | 5 | 8 | 2 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 5.00 | Average Number Of Links With An Hub | 3.00 | Average Interaction Strength | 8.37 | Average Nodes In Shell | 16.00 | Average Hubs In Shell | 8.00 | Average Links In Shell | 18.00 | Average Links Mediated by Hubs In Shell | 18.00 |
| ![](/psngpcr/ligands/NFA/NFA_7F8W_L_L_17_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/NFA/NFA_7F8W_L_L_17_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
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Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 9AUC | B1 | Peptide | Calcitonin | CT | Homo Sapiens | Calcitonin gene-related peptide-1 | - | Gs/Beta1/Gamma2; RAMP1 | 2.4 | 2024-04-24 | 10.1021/acs.biochem.4c00114 |
![](/psngpcr/ligands/NFA/NFA_9AUC_L_L_37.png)
A 2D representation of the interactions of NFA in 9AUC colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | E:E:T73 | E:E:W84 | 8.49 | 1 | No | Yes | 9 | 9 | 2 | 1 | E:E:T73 | E:E:V89 | 7.93 | 1 | No | No | 9 | 9 | 2 | 2 | E:E:W74 | E:E:W84 | 5.62 | 0 | No | Yes | 1 | 9 | 2 | 1 | E:E:F83 | R:R:R126 | 23.52 | 0 | No | No | 5 | 4 | 2 | 1 | E:E:P85 | E:E:W84 | 18.92 | 0 | No | Yes | 9 | 9 | 2 | 1 | E:E:V89 | E:E:W84 | 6.13 | 1 | No | Yes | 9 | 9 | 2 | 1 | E:E:W84 | L:L:?37 | 3.64 | 1 | Yes | Yes | 9 | 0 | 1 | 0 | E:E:W84 | R:R:Q52 | 4.38 | 1 | Yes | Yes | 9 | 6 | 1 | 2 | E:E:P85 | R:R:G78 | 4.06 | 0 | No | No | 9 | 5 | 2 | 1 | L:L:?37 | L:L:A36 | 3.78 | 1 | Yes | No | 0 | 0 | 0 | 1 | L:L:?37 | R:R:D77 | 3.26 | 1 | Yes | Yes | 0 | 9 | 0 | 1 | L:L:?37 | R:R:G78 | 8.21 | 1 | Yes | No | 0 | 5 | 0 | 1 | L:L:?37 | R:R:W79 | 9.11 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | L:L:?37 | R:R:R126 | 7.77 | 1 | Yes | No | 0 | 4 | 0 | 1 | L:L:?37 | R:R:W128 | 6.38 | 1 | Yes | Yes | 0 | 5 | 0 | 1 | L:L:?37 | R:R:S129 | 6 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | L:L:?37 | R:R:Y131 | 3.75 | 1 | Yes | Yes | 0 | 5 | 0 | 1 | R:R:M48 | R:R:W79 | 5.82 | 1 | No | Yes | 6 | 6 | 2 | 1 | R:R:M48 | R:R:Y98 | 9.58 | 1 | No | Yes | 6 | 4 | 2 | 2 | R:R:D77 | R:R:G78 | 3.35 | 1 | Yes | No | 9 | 5 | 1 | 1 | R:R:D77 | R:R:L80 | 4.07 | 1 | Yes | Yes | 9 | 5 | 1 | 2 | R:R:D77 | R:R:W82 | 8.93 | 1 | Yes | No | 9 | 9 | 1 | 2 | R:R:D77 | R:R:S129 | 4.42 | 1 | Yes | Yes | 9 | 7 | 1 | 1 | R:R:D77 | R:R:Y131 | 5.75 | 1 | Yes | Yes | 9 | 5 | 1 | 1 | R:R:W79 | R:R:Y98 | 5.79 | 1 | Yes | Yes | 6 | 4 | 1 | 2 | R:R:F99 | R:R:W79 | 9.02 | 1 | Yes | Yes | 5 | 6 | 2 | 1 | R:R:F102 | R:R:W79 | 7.02 | 1 | Yes | Yes | 4 | 6 | 2 | 1 | R:R:W79 | R:R:Y131 | 19.29 | 1 | Yes | Yes | 6 | 5 | 1 | 1 | R:R:L80 | R:R:V108 | 4.47 | 1 | Yes | No | 5 | 7 | 2 | 2 | R:R:L80 | R:R:Y131 | 5.86 | 1 | Yes | Yes | 5 | 5 | 2 | 1 | R:R:K110 | R:R:W82 | 19.73 | 0 | Yes | No | 8 | 9 | 2 | 2 | R:R:F102 | R:R:F99 | 12.86 | 1 | Yes | Yes | 4 | 5 | 2 | 2 | R:R:V108 | R:R:Y131 | 10.09 | 1 | No | Yes | 7 | 5 | 2 | 1 | R:R:K110 | R:R:S129 | 10.71 | 0 | Yes | Yes | 8 | 7 | 2 | 1 | R:R:H121 | R:R:W128 | 19.04 | 0 | No | Yes | 4 | 5 | 2 | 1 | R:R:N130 | R:R:W128 | 7.91 | 1 | Yes | Yes | 8 | 5 | 2 | 1 | H:H:?4 | R:R:W128 | 7.11 | 1 | Yes | Yes | 0 | 5 | 2 | 1 | R:R:S129 | R:R:Y131 | 5.09 | 1 | Yes | Yes | 7 | 5 | 1 | 1 | H:H:?4 | R:R:N130 | 28.17 | 1 | Yes | Yes | 0 | 8 | 2 | 2 | |
Statistics | Value |
---|
Average Number Of Links | 9.00 | Average Number Of Links With An Hub | 6.00 | Average Interaction Strength | 5.77 | Average Nodes In Shell | 27.00 | Average Hubs In Shell | 15.00 | Average Links In Shell | 39.00 | Average Links Mediated by Hubs In Shell | 36.00 |
| ![](/psngpcr/ligands/NFA/NFA_9AUC_L_L_37_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/NFA/NFA_9AUC_L_L_37_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|