psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	E:E:G33	E:E:L36	5.13	No	No	0	4	7
2	E:E:E38	E:E:L35	5.3	No	No	0	4	3
3	E:E:L36	E:E:L80	4.15	No	No	0	7	5
4	E:E:R37	E:E:T73	3.88	Yes	Yes	4	4	9
5	E:E:N86	E:E:R37	10.85	No	Yes	4	8	4
6	E:E:E88	E:E:R37	3.49	No	Yes	4	4	4
7	E:E:R37	E:E:V89	5.23	Yes	No	4	4	9
8	E:E:F92	E:E:R37	5.34	Yes	Yes	4	8	4
9	E:E:C40	E:E:E68	4.56	No	No	4	9	4
10	E:E:C40	E:E:C72	7.28	No	No	4	9	9
11	E:E:F44	E:E:L41	3.65	Yes	Yes	0	9	7
12	E:E:L41	E:E:Q45	3.99	Yes	No	0	7	4
13	E:E:F92	E:E:L41	10.96	Yes	Yes	0	8	7
14	E:E:D47	E:E:Q43	5.22	No	No	0	6	4
15	E:E:F44	E:E:M48	4.98	Yes	No	4	9	9
16	E:E:F44	E:E:S65	3.96	Yes	No	4	9	5
17	E:E:F44	E:E:L69	21.92	Yes	Yes	4	9	8
18	E:E:Q45	E:E:Y100	6.76	No	Yes	0	4	9
19	E:E:M48	E:E:R61	4.96	No	No	0	9	5
20	E:E:M48	E:E:S65	6.13	No	No	4	9	5
21	E:E:E49	E:E:W56	20.72	No	No	11	4	9
22	E:E:E49	E:E:Y100	22.45	No	Yes	11	4	9
23	E:E:E53	E:E:G52	3.27	No	No	0	4	6
24	E:E:G52	E:E:L55	6.84	No	No	0	6	4
25	E:E:L55	E:E:R61	12.15	No	No	0	4	5
26	E:E:W56	E:E:Y100	24.12	No	Yes	11	9	9
27	E:E:C104	E:E:C57	7.28	No	No	0	9	9
28	E:E:D58	E:E:G60	3.35	No	No	0	7	3
29	E:E:G60	E:E:W59	7.04	No	No	0	3	9
30	E:E:R61	E:E:R64	4.26	No	No	0	5	3
31	E:E:S65	E:E:T62	3.2	No	No	0	5	9
32	E:E:F101	E:E:T62	7.78	No	No	0	9	9
33	E:E:I63	E:E:R67	5.01	Yes	No	0	4	3
34	E:E:I63	R:R:K46	8.72	Yes	No	12	4	4
35	E:E:I63	R:R:D50	5.6	Yes	No	12	4	2
36	E:E:R64	E:E:R67	8.53	No	No	0	3	3
37	E:E:F93	E:E:Y66	9.28	Yes	Yes	0	9	9
38	E:E:H97	E:E:Y66	13.07	Yes	Yes	0	9	9
39	E:E:F101	E:E:Y66	5.16	No	Yes	0	9	9
40	E:E:Y66	R:R:Q52	5.64	Yes	No	0	9	6
41	E:E:R67	R:R:M49	8.69	No	No	0	3	4
42	E:E:C72	E:E:E68	6.08	No	No	4	9	4
43	E:E:F92	E:E:L69	7.31	Yes	Yes	4	8	8
44	E:E:F93	E:E:L69	9.74	Yes	Yes	4	9	8
45	E:E:L69	E:E:V96	4.47	Yes	No	0	8	7
46	E:E:D71	E:E:H75	15.13	No	No	0	8	4
47	E:E:T73	E:E:W84	4.85	Yes	Yes	0	9	9
48	E:E:T73	E:E:V89	4.76	Yes	No	4	9	9
49	E:E:F92	E:E:T73	6.49	Yes	Yes	4	8	9
50	E:E:W74	E:E:W84	11.25	No	Yes	0	1	9
51	E:E:A77	E:E:W84	3.89	No	Yes	0	9	9
52	E:E:E78	E:E:K79	16.2	No	No	0	1	3
53	E:E:C82	E:E:L80	3.17	No	No	0	9	5
54	E:E:F83	R:R:R126	31	No	No	0	5	4
55	E:E:P85	E:E:W84	6.76	No	Yes	0	9	9
56	E:E:P85	L:L:Y37	5.56	No	Yes	0	9	0
57	E:E:P85	R:R:R126	4.32	No	No	0	9	4
58	E:E:E88	E:E:N86	10.52	No	No	4	4	8
59	E:E:N86	E:E:V89	11.82	No	No	4	8	9
60	E:E:D90	R:R:Y56	9.2	No	Yes	0	9	3
61	E:E:D90	R:R:T75	5.78	No	No	0	9	5
62	E:E:F92	E:E:F93	3.22	Yes	Yes	4	8	9
63	E:E:F93	R:R:Y56	9.28	Yes	Yes	0	9	3
64	E:E:L94	R:R:Y56	4.69	No	Yes	0	5	3
65	E:E:L94	R:R:M59	5.65	No	No	0	5	5
66	E:E:H97	R:R:Y53	4.36	Yes	Yes	13	9	1
67	E:E:H97	R:R:Y56	5.44	Yes	Yes	0	9	3
68	E:E:H97	R:R:D57	11.35	Yes	No	13	9	4
69	E:E:R99	E:E:Y100	17.49	No	Yes	0	3	9
70	E:E:F101	R:R:Y53	11.35	No	Yes	0	9	1
71	E:E:R102	R:R:D57	10.72	No	No	0	4	4
72	E:E:I106	R:R:Y53	7.25	No	Yes	0	4	1
73	E:E:G108	E:E:S107	3.71	No	No	0	9	7
74	E:E:R109	E:E:R112	7.46	No	No	0	9	4
75	E:E:R109	R:R:K54	8.66	No	No	0	9	4
76	E:E:V111	R:R:F285	9.18	No	Yes	0	5	6
77	E:E:D113	E:E:P114	3.22	Yes	Yes	3	9	9
78	E:E:D113	R:R:F285	5.97	Yes	Yes	3	9	6
79	E:E:D113	R:R:T295	8.67	Yes	Yes	3	9	4
80	E:E:D113	R:R:H296	5.04	Yes	No	0	9	2
81	E:E:D113	R:R:L297	5.43	Yes	Yes	3	9	4
82	E:E:I118	E:E:P114	3.39	Yes	Yes	3	6	9
83	E:E:P114	R:R:Y284	18.08	Yes	No	3	9	2
84	E:E:P114	R:R:L297	3.28	Yes	Yes	3	9	4
85	E:E:I118	E:E:P115	3.39	Yes	No	0	6	9
86	E:E:G116	E:E:Y120	5.79	No	No	0	4	6
87	E:E:F122	E:E:I118	3.77	No	Yes	0	8	6
88	E:E:I118	R:R:Y284	3.63	Yes	No	3	6	2
89	E:E:I123	E:E:L119	4.28	No	No	0	9	9
90	E:E:F122	R:R:T280	6.49	No	No	0	8	4
91	E:E:P126	E:E:V125	3.53	No	No	0	9	6
92	E:E:P126	R:R:P304	3.9	No	Yes	0	9	9
93	E:E:I127	R:R:G303	3.53	No	No	5	6	4
94	E:E:I127	R:R:P304	3.39	No	Yes	5	6	9
95	E:E:T130	R:R:F235	3.89	Yes	Yes	5	9	5
96	E:E:T130	R:R:F269	6.49	Yes	Yes	5	9	3
97	E:E:T130	R:R:P304	6.99	Yes	Yes	5	9	9
98	E:E:V133	R:R:F269	13.11	No	Yes	0	7	3
99	E:E:T134	R:R:L238	5.9	No	Yes	0	9	8
100	E:E:V137	R:R:I242	4.61	No	Yes	0	9	7
101	E:E:V137	R:R:L265	7.45	No	Yes	0	9	7
102	E:E:V138	R:R:I242	4.61	No	Yes	0	9	7
103	E:E:Q140	E:E:W139	8.76	No	No	0	8	9
104	E:E:R143	E:E:W139	14.99	No	No	0	6	9
105	E:E:Q140	R:R:R258	5.84	No	No	9	8	5
106	E:E:Q140	R:R:W261	12.05	No	Yes	9	8	2
107	E:E:S141	R:R:T246	6.4	No	No	1	9	7
108	E:E:S141	R:R:Q257	5.78	No	Yes	1	9	5
109	E:E:S141	R:R:Y262	6.36	No	Yes	1	9	7
110	E:E:K142	R:R:V250	6.07	No	No	0	8	5
111	L:L:K1	L:L:R11	6.19	No	No	14	0	0
112	L:L:K1	R:R:V293	4.55	No	No	14	0	6
113	L:L:K1	R:R:E294	6.75	No	No	0	0	3
114	L:L:C2	L:L:T4	3.38	No	No	1	0	0
115	L:L:C2	L:L:C7	7.28	No	No	1	0	0
116	L:L:C2	R:R:Y299	5.38	No	No	0	0	7
117	L:L:N3	L:L:R11	4.82	No	No	0	0	0
118	L:L:N3	R:R:W361	18.08	No	No	0	0	4
119	L:L:N3	R:R:R362	4.82	No	Yes	0	0	4
120	L:L:T4	L:L:T6	3.14	No	Yes	1	0	0
121	L:L:C7	L:L:T4	3.38	No	No	1	0	0
122	L:L:T6	R:R:Y234	8.74	Yes	Yes	1	0	7
123	L:L:T6	R:R:H302	8.21	Yes	Yes	1	0	6
124	L:L:T6	R:R:V305	4.76	Yes	No	1	0	7
125	L:L:T6	R:R:F356	5.19	Yes	Yes	1	0	7
126	L:L:C7	R:R:H302	10.32	No	Yes	1	0	6
127	L:L:T9	R:R:H381	4.11	No	Yes	0	0	9
128	L:L:Q10	R:R:H226	3.71	No	No	0	0	6
129	L:L:Q10	R:R:M230	5.44	No	No	1	0	6
130	L:L:Q10	R:R:H302	6.18	No	Yes	1	0	6
131	L:L:R11	R:R:V293	3.92	No	No	14	0	6
132	L:L:L12	L:L:L16	4.15	No	Yes	0	0	0
133	L:L:L12	R:R:H377	6.43	No	Yes	0	0	7
134	L:L:N14	R:R:V293	4.43	No	No	0	0	6
135	L:L:F15	L:L:S19	7.93	No	No	0	0	0
136	L:L:F15	R:R:K141	18.61	No	No	0	0	3
137	L:L:L16	L:L:S20	4.5	Yes	No	8	0	0
138	L:L:L16	L:L:L23	9.69	Yes	Yes	8	0	0
139	L:L:L16	R:R:A145	3.15	Yes	No	0	0	4
140	L:L:L16	R:R:Y149	4.69	Yes	Yes	8	0	5
141	L:L:V17	R:R:V206	4.81	No	No	0	0	3
142	L:L:V17	R:R:V212	4.81	No	No	6	0	3
143	L:L:V17	R:R:L291	4.47	No	No	6	0	6
144	L:L:R18	R:R:P104	8.65	No	No	0	0	3
145	L:L:L23	L:L:S20	7.51	Yes	No	8	0	0
146	L:L:S20	R:R:Y146	3.82	No	No	8	0	2
147	L:L:L27	L:L:N21	5.49	No	No	0	0	0
148	L:L:L23	R:R:Y146	5.86	Yes	No	8	0	2
149	L:L:L23	R:R:Y149	7.03	Yes	Yes	8	0	5
150	L:L:G24	L:L:P25	4.06	No	No	0	0	0
151	L:L:L27	L:L:P28	6.57	No	No	0	0	0
152	L:L:T30	L:L:V32	3.17	Yes	No	0	0	0
153	L:L:T30	R:R:F99	5.19	Yes	Yes	2	0	5
154	L:L:T30	R:R:D101	7.23	Yes	Yes	0	0	4
155	L:L:T30	R:R:F102	3.89	Yes	Yes	2	0	4
156	L:L:V32	R:R:N135	8.87	No	Yes	0	0	3
157	L:L:S34	R:R:E123	10.06	No	No	0	0	4
158	L:L:S34	R:R:N124	5.96	No	No	0	0	5
159	L:L:?38	L:L:T36	7.3	Yes	Yes	0	0	0
160	L:L:T36	R:R:W79	4.85	Yes	Yes	0	0	6
161	L:L:Y37	R:R:D77	3.45	Yes	Yes	0	0	9
162	L:L:Y37	R:R:G78	10.14	Yes	No	0	0	5
163	L:L:Y37	R:R:W79	14.47	Yes	Yes	0	0	6
164	L:L:?38	R:R:W128	14.09	Yes	Yes	2	0	5
165	L:L:?38	R:R:S129	3.72	Yes	Yes	2	0	7
166	L:L:?38	R:R:Y131	5.8	Yes	Yes	2	0	5
167	R:R:K46	R:R:M49	7.2	No	No	0	4	4
168	R:R:D50	R:R:K46	6.91	No	No	12	2	4
169	R:R:D97	R:R:K47	11.06	No	No	0	2	4
170	R:R:K47	R:R:Y98	8.36	No	Yes	0	4	4
171	R:R:M48	R:R:W79	3.49	No	Yes	2	6	6
172	R:R:M48	R:R:Y98	9.58	No	Yes	2	6	4
173	R:R:A51	R:R:W76	3.89	No	Yes	0	8	8
174	R:R:Q52	R:R:W76	9.86	No	Yes	0	6	8
175	R:R:D57	R:R:Y53	5.75	No	Yes	13	4	1
176	R:R:C55	R:R:W76	6.53	No	Yes	15	9	8
177	R:R:C55	R:R:C81	7.28	No	No	15	9	9
178	R:R:W76	R:R:Y56	9.65	Yes	Yes	0	8	3
179	R:R:L62	R:R:R58	7.29	Yes	No	10	3	3
180	R:R:D83	R:R:R58	11.91	No	No	10	5	3
181	R:R:L62	R:R:P63	3.28	Yes	No	0	3	1
182	R:R:L62	R:R:R74	12.15	Yes	No	10	3	4
183	R:R:D83	R:R:L62	4.07	No	Yes	10	5	3
184	R:R:Y65	R:R:Y71	29.79	Yes	No	0	3	3
185	R:R:D84	R:R:Y65	9.2	No	Yes	0	4	3
186	R:R:P86	R:R:Y65	5.56	No	Yes	0	2	3
187	R:R:G69	R:R:P70	4.06	No	No	0	1	1
188	R:R:N73	R:R:Y71	8.14	No	No	16	4	3
189	H:H:?1	R:R:Y71	4.21	No	No	16	0	3
190	R:R:C112	R:R:C72	7.28	No	No	0	9	9
191	R:R:C72	R:R:W118	22.2	No	Yes	0	9	9
192	H:H:?1	R:R:N73	29.57	No	No	16	0	4
193	R:R:D83	R:R:R74	7.15	No	No	10	5	4
194	R:R:D84	R:R:R74	20.25	No	No	0	4	4
195	R:R:T75	R:R:W118	8.49	No	Yes	0	5	9
196	R:R:C81	R:R:W76	7.84	No	Yes	15	9	8
197	R:R:D77	R:R:L80	4.07	Yes	Yes	2	9	5
198	R:R:D77	R:R:W82	8.93	Yes	Yes	2	9	9
199	R:R:D77	R:R:S129	5.89	Yes	Yes	2	9	7
200	R:R:D77	R:R:Y131	5.75	Yes	Yes	2	9	5
201	R:R:W79	R:R:Y98	5.79	Yes	Yes	2	6	4
202	R:R:F99	R:R:W79	13.03	Yes	Yes	2	5	6
203	R:R:F102	R:R:W79	4.01	Yes	Yes	2	4	6
204	R:R:W79	R:R:Y131	23.15	Yes	Yes	2	6	5
205	R:R:L80	R:R:Q93	5.32	Yes	No	0	5	6
206	R:R:L80	R:R:P96	9.85	Yes	No	0	5	9
207	R:R:L80	R:R:V108	4.47	Yes	Yes	2	5	7
208	R:R:L80	R:R:Y131	5.86	Yes	Yes	2	5	5
209	R:R:S91	R:R:W82	6.18	No	Yes	0	5	9
210	R:R:Q93	R:R:W82	3.29	No	Yes	0	6	9
211	R:R:V108	R:R:W82	3.68	Yes	Yes	2	7	9
212	R:R:K110	R:R:W82	18.57	No	Yes	2	8	9
213	R:R:S129	R:R:W82	4.94	Yes	Yes	2	7	9
214	R:R:P86	R:R:T85	3.5	No	No	17	2	7
215	R:R:T85	R:R:V89	3.17	No	No	17	7	5
216	R:R:S91	R:R:T85	9.59	No	No	0	5	7
217	R:R:P86	R:R:V89	8.84	No	No	17	2	5
218	R:R:G88	R:R:Y111	4.35	No	No	0	8	4
219	R:R:L90	R:R:Y111	5.86	No	No	0	4	4
220	R:R:K107	R:R:Y92	3.58	No	No	0	3	4
221	R:R:F94	R:R:K107	3.72	No	No	0	3	3
222	R:R:C95	R:R:P96	3.77	Yes	No	0	9	9
223	R:R:C95	R:R:F102	5.59	Yes	Yes	2	9	4
224	R:R:C95	R:R:V108	3.42	Yes	Yes	2	9	7
225	R:R:C134	R:R:C95	7.28	No	Yes	2	9	9
226	R:R:P96	R:R:Y98	15.3	No	Yes	0	9	4
227	R:R:F99	R:R:Y98	5.16	Yes	Yes	2	5	4
228	R:R:F102	R:R:F99	15	Yes	Yes	2	4	5
229	R:R:D101	R:R:P100	3.22	Yes	No	0	4	4
230	R:R:D101	R:R:N135	6.73	Yes	Yes	0	4	3
231	R:R:C134	R:R:F102	11.17	No	Yes	2	9	4
232	R:R:F102	R:R:N135	7.25	Yes	Yes	0	4	3
233	R:R:D103	R:R:P104	4.83	No	No	0	3	3
234	R:R:D103	R:R:S105	5.89	No	No	0	3	1
235	R:R:D103	R:R:E106	3.9	No	Yes	0	3	4
236	R:R:E294	R:R:P104	3.14	No	No	0	3	3
237	R:R:E106	R:R:M133	5.41	Yes	Yes	2	4	5
238	R:R:E106	R:R:F137	7	Yes	No	2	4	1
239	R:R:E106	R:R:K366	5.4	Yes	No	2	4	3
240	R:R:V108	R:R:Y131	12.62	Yes	Yes	2	7	5
241	R:R:N130	R:R:T109	11.7	No	No	0	8	5
242	R:R:K110	R:R:W118	22.05	No	Yes	0	8	9
243	R:R:K110	R:R:S129	9.18	No	Yes	2	8	7
244	R:R:D113	R:R:K115	4.15	Yes	No	0	5	5
245	R:R:D113	R:R:V117	8.76	Yes	No	0	5	5
246	R:R:T127	R:R:W118	4.85	No	Yes	0	4	9
247	R:R:H121	R:R:P122	6.1	Yes	No	0	4	5
248	R:R:E123	R:R:H121	18.46	No	Yes	0	4	4
249	R:R:H121	R:R:W128	6.35	Yes	Yes	2	4	5
250	H:H:?2	R:R:H121	4.61	Yes	Yes	2	0	4
251	H:H:?2	R:R:W128	10.22	Yes	Yes	2	0	5
252	R:R:S129	R:R:Y131	6.36	Yes	Yes	2	7	5
253	H:H:?2	R:R:N130	25.87	Yes	No	0	0	8
254	H:H:?2	R:R:T132	9.26	Yes	No	0	0	6
255	R:R:F137	R:R:M133	9.95	No	Yes	2	1	5
256	H:H:?2	R:R:M133	7.61	Yes	Yes	2	0	5
257	R:R:F137	R:R:K366	7.44	No	No	2	1	3
258	R:R:P139	R:R:T138	5.25	No	No	0	3	2
259	R:R:E140	R:R:K143	4.05	No	No	0	2	1
260	R:R:L142	R:R:Y146	9.38	No	No	0	2	2
261	R:R:K370	R:R:N144	8.39	No	No	18	4	4
262	R:R:N144	R:R:Y374	5.81	No	Yes	18	4	6
263	R:R:V147	R:R:Y374	8.83	No	Yes	0	4	6
264	R:R:D373	R:R:L148	5.43	No	No	0	5	5
265	R:R:L148	R:R:Y374	3.52	No	Yes	0	5	6
266	R:R:H377	R:R:L148	10.29	Yes	No	0	7	5
267	R:R:Y149	R:R:Y150	9.93	Yes	No	0	5	4
268	R:R:L202	R:R:Y149	5.86	No	Yes	0	7	5
269	R:R:F382	R:R:L151	3.65	No	No	0	7	5
270	R:R:A152	R:R:H381	7.32	No	Yes	0	7	9
271	R:R:F382	R:R:G155	9.03	No	No	0	7	8
272	R:R:H156	R:R:S195	11.16	Yes	No	0	7	7
273	R:R:H156	R:R:I198	11.93	Yes	No	0	7	7
274	R:R:H156	R:R:H381	10.75	Yes	Yes	0	7	9
275	R:R:F385	R:R:L158	15.83	Yes	No	0	5	4
276	R:R:G384	R:R:S159	3.71	No	No	0	9	9
277	R:R:I160	R:R:S195	4.64	No	No	0	5	7
278	R:R:I160	R:R:M196	4.37	No	No	0	5	4
279	R:R:F161	R:R:I165	6.28	No	No	0	4	5
280	R:R:F385	R:R:T162	7.78	Yes	No	0	5	6
281	R:R:A388	R:R:T162	3.36	No	No	0	8	6
282	R:R:F393	R:R:T162	5.19	Yes	No	0	8	6
283	R:R:F188	R:R:L163	6.09	Yes	No	0	8	8
284	R:R:I192	R:R:L163	4.28	No	No	0	7	8
285	R:R:A388	R:R:L163	3.15	No	No	0	8	8
286	R:R:F393	R:R:I165	3.77	Yes	No	0	8	5
287	R:R:F188	R:R:S166	5.28	Yes	Yes	0	8	9
288	R:R:A388	R:R:S166	3.42	No	Yes	0	8	9
289	R:R:C392	R:R:S166	6.89	No	Yes	0	9	9
290	R:R:F393	R:R:S166	5.28	Yes	Yes	0	8	9
291	R:R:K185	R:R:L167	4.23	No	No	0	6	6
292	R:R:F188	R:R:L167	3.65	Yes	No	0	8	6
293	R:R:F173	R:R:I169	5.02	Yes	No	0	7	8
294	R:R:C392	R:R:I169	4.91	No	No	0	9	8
295	R:R:F170	R:R:L176	3.65	Yes	Yes	0	8	9
296	R:R:F170	R:R:V181	10.49	Yes	No	0	8	9
297	R:R:F170	R:R:F188	6.43	Yes	Yes	0	8	8
298	R:R:C392	R:R:F170	8.38	No	Yes	0	9	8
299	R:R:F172	R:R:F173	9.65	No	Yes	19	2	7
300	R:R:F172	R:R:F409	7.5	No	Yes	19	2	3
301	R:R:F173	R:R:T401	3.89	Yes	No	0	7	7
302	R:R:F173	R:R:V402	5.24	Yes	No	0	7	5
303	R:R:F173	R:R:Q405	3.51	Yes	No	0	7	4
304	R:R:F173	R:R:F409	3.22	Yes	Yes	19	7	3
305	R:R:S175	R:R:T401	4.8	No	No	0	8	7
306	R:R:E397	R:R:L176	5.3	No	Yes	0	9	9
307	R:R:L176	R:R:V398	5.96	Yes	No	0	9	9
308	R:R:L176	R:R:T401	10.32	Yes	No	0	9	7
309	R:R:C178	R:R:R180	5.57	No	Yes	20	8	9
310	R:R:C178	R:R:V181	3.42	No	No	20	8	9
311	R:R:Q179	R:R:Y243	6.76	Yes	Yes	1	7	8
312	R:R:K256	R:R:Q179	5.42	No	Yes	0	5	7
313	R:R:Q179	R:R:Q257	3.84	Yes	Yes	1	7	5
314	R:R:L259	R:R:Q179	13.31	No	Yes	0	5	7
315	R:R:R180	R:R:V181	3.92	Yes	No	20	9	9
316	R:R:H184	R:R:R180	5.64	No	Yes	0	9	9
317	R:R:E397	R:R:R180	3.49	No	Yes	0	9	9
318	R:R:L183	R:R:W236	4.56	No	Yes	1	8	9
319	R:R:L183	R:R:Y243	5.86	No	Yes	1	8	8
320	R:R:L183	R:R:Y262	5.86	No	Yes	1	8	7
321	R:R:E240	R:R:H184	11.08	No	No	0	9	9
322	R:R:H184	R:R:Y391	4.36	No	Yes	0	9	8
323	R:R:N186	R:R:W236	15.82	No	Yes	1	9	9
324	R:R:N186	R:R:Y263	9.3	No	No	1	9	5
325	R:R:N186	R:R:W267	6.78	No	Yes	1	9	9
326	R:R:M187	R:R:Y191	8.38	No	Yes	0	8	8
327	R:R:E240	R:R:M187	8.12	No	No	0	9	8
328	R:R:F188	R:R:V387	3.93	Yes	No	0	8	9
329	R:R:L189	R:R:L193	6.92	No	No	0	3	6
330	R:R:N233	R:R:T190	8.77	No	No	1	9	9
331	R:R:T190	R:R:W236	6.06	No	Yes	1	9	9
332	R:R:T190	R:R:W267	3.64	No	Yes	1	9	9
333	R:R:N233	R:R:Y191	15.12	No	Yes	1	9	8
334	R:R:M237	R:R:Y191	5.99	Yes	Yes	1	9	8
335	R:R:Q383	R:R:Y191	13.53	Yes	Yes	1	9	8
336	R:R:G384	R:R:Y191	8.69	No	Yes	0	9	8
337	R:R:V387	R:R:Y191	6.31	No	Yes	0	9	8
338	R:R:L193	R:R:M229	8.48	No	No	0	6	4
339	R:R:I198	R:R:N194	7.08	No	No	0	7	8
340	R:R:H226	R:R:I198	3.98	No	No	0	6	7
341	R:R:E204	R:R:I200	5.47	No	No	0	4	6
342	R:R:H201	R:R:V205	12.45	No	No	0	6	7
343	R:R:C219	R:R:V205	3.42	Yes	No	0	9	7
344	R:R:P207	R:R:V206	5.3	No	No	0	3	3
345	R:R:L211	R:R:N208	6.87	Yes	No	0	1	3
346	R:R:E210	R:R:R213	5.82	No	No	0	3	2
347	R:R:L211	R:R:R214	4.86	Yes	No	0	1	4
348	R:R:L211	R:R:P216	8.21	Yes	No	6	1	4
349	R:R:C219	R:R:L211	3.17	Yes	Yes	6	9	1
350	R:R:C289	R:R:V212	5.12	No	No	6	9	3
351	R:R:L291	R:R:V212	4.47	No	No	6	6	3
352	R:R:D215	R:R:K220	11.06	No	No	0	6	7
353	R:R:D215	R:R:N288	10.77	No	No	0	6	4
354	R:R:C219	R:R:P216	3.77	Yes	No	6	9	4
355	R:R:C219	R:R:C289	7.28	Yes	No	6	9	9
356	R:R:K220	R:R:N286	6.99	No	No	3	7	7
357	R:R:K220	R:R:W290	30.17	No	Yes	3	7	9
358	R:R:H223	R:R:Q227	17.31	No	No	0	5	7
359	R:R:H223	R:R:W290	11.64	No	Yes	0	5	9
360	R:R:H277	R:R:Q227	11.13	Yes	No	3	7	7
361	R:R:I301	R:R:Q227	6.86	No	No	3	7	7
362	R:R:C232	R:R:Y228	9.41	No	No	0	8	8
363	R:R:L271	R:R:Y228	5.86	No	No	0	4	8
364	R:R:T274	R:R:Y228	3.75	No	No	0	6	8
365	R:R:M230	R:R:Y234	5.99	No	Yes	1	6	7
366	R:R:H302	R:R:M230	6.57	Yes	No	1	6	6
367	R:R:A231	R:R:P270	3.74	No	Yes	0	5	9
368	R:R:C232	R:R:W267	5.22	No	Yes	0	8	9
369	R:R:C232	R:R:P270	7.53	No	Yes	0	8	9
370	R:R:M237	R:R:N233	4.21	Yes	No	1	9	9
371	R:R:M237	R:R:Y234	3.59	Yes	Yes	1	9	7
372	R:R:V305	R:R:Y234	13.88	No	Yes	1	7	7
373	R:R:L309	R:R:Y234	5.86	No	Yes	1	7	7
374	R:R:F356	R:R:Y234	14.44	Yes	Yes	1	7	7
375	R:R:F235	R:R:L265	3.65	Yes	Yes	5	5	7
376	R:R:F235	R:R:F269	8.57	Yes	Yes	5	5	3
377	R:R:F235	R:R:P270	4.33	Yes	Yes	5	5	9
378	R:R:A308	R:R:F235	4.16	No	Yes	0	7	5
379	R:R:C239	R:R:W236	7.84	No	Yes	0	7	9
380	R:R:W236	R:R:Y263	3.86	Yes	No	1	9	5
381	R:R:G266	R:R:W236	7.04	No	Yes	0	9	9
382	R:R:W236	R:R:W267	15.93	Yes	Yes	1	9	9
383	R:R:M237	R:R:Q383	5.44	Yes	Yes	1	9	9
384	R:R:I242	R:R:L238	7.14	Yes	Yes	0	7	8
385	R:R:A308	R:R:L238	4.73	No	Yes	0	7	8
386	R:R:L238	R:R:N312	5.49	Yes	No	0	8	9
387	R:R:C239	R:R:Y262	5.38	No	Yes	0	7	7
388	R:R:C239	R:R:L265	4.76	No	Yes	0	7	7
389	R:R:E240	R:R:L351	10.6	No	No	0	9	9
390	R:R:G241	R:R:N312	5.09	No	No	0	8	9
391	R:R:I242	R:R:Y262	4.84	Yes	Yes	0	7	7
392	R:R:F315	R:R:I242	3.77	No	Yes	0	8	7
393	R:R:L247	R:R:Y243	11.72	No	Yes	0	8	8
394	R:R:Q257	R:R:Y243	11.27	Yes	Yes	1	5	8
395	R:R:Y243	R:R:Y262	6.95	Yes	Yes	1	8	7
396	R:R:I248	R:R:L244	4.28	Yes	No	7	7	9
397	R:R:I319	R:R:L244	4.28	No	No	7	9	9
398	R:R:H245	R:R:V249	15.22	Yes	No	7	8	6
399	R:R:H245	R:R:V250	5.54	Yes	No	7	8	5
400	R:R:F315	R:R:H245	26.02	No	Yes	0	8	8
401	R:R:H245	R:R:N318	10.2	Yes	No	0	8	8
402	R:R:Q257	R:R:T246	8.5	Yes	No	1	5	7
403	R:R:I248	R:R:I319	4.42	Yes	No	7	7	9
404	R:R:V249	R:R:V250	3.21	No	No	7	6	5
405	R:R:A251	R:R:T254	3.36	No	No	0	6	6
406	R:R:Q257	R:R:Y262	10.15	Yes	Yes	1	5	7
407	R:R:R258	R:R:R260	11.73	No	No	9	5	3
408	R:R:R258	R:R:W261	11	No	Yes	9	5	2
409	R:R:L259	R:R:Y262	3.52	No	Yes	0	5	7
410	R:R:L259	R:R:Y263	7.03	No	No	0	5	5
411	R:R:R260	R:R:W261	11	No	Yes	9	3	2
412	R:R:F269	R:R:L265	3.65	Yes	Yes	5	3	7
413	R:R:F269	R:R:P270	4.33	Yes	Yes	5	3	9
414	R:R:F269	R:R:V272	3.93	Yes	No	0	3	4
415	R:R:P273	R:R:V272	3.53	No	No	0	6	4
416	R:R:I301	R:R:T274	6.08	No	No	0	7	6
417	R:R:I276	R:R:I300	4.42	No	No	0	5	8
418	R:R:H277	R:R:R281	12.41	Yes	Yes	3	7	7
419	R:R:H277	R:R:L298	3.86	Yes	No	0	7	6
420	R:R:H277	R:R:I300	6.63	Yes	No	0	7	8
421	R:R:H277	R:R:I301	9.28	Yes	No	3	7	7
422	R:R:L297	R:R:T280	7.37	Yes	No	0	4	4
423	R:R:I300	R:R:T280	4.56	No	No	0	8	4
424	R:R:F285	R:R:R281	7.48	Yes	Yes	3	6	7
425	R:R:D287	R:R:R281	8.34	No	Yes	3	3	7
426	R:R:R281	R:R:W290	10	Yes	Yes	3	7	9
427	R:R:R281	R:R:T295	7.76	Yes	Yes	3	7	4
428	R:R:L297	R:R:R281	3.64	Yes	Yes	3	4	7
429	R:R:V283	R:R:Y284	11.36	No	No	0	3	2
430	R:R:D287	R:R:F285	9.55	No	Yes	3	3	6
431	R:R:F285	R:R:S292	5.28	Yes	No	3	6	4
432	R:R:F285	R:R:T295	19.46	Yes	Yes	3	6	4
433	R:R:N286	R:R:W290	5.65	No	Yes	3	7	9
434	R:R:D287	R:R:S292	7.36	No	No	3	3	4
435	R:R:C289	R:R:L291	3.17	No	No	6	9	6
436	R:R:L297	R:R:T295	7.37	Yes	Yes	3	4	4
437	R:R:H296	R:R:Y299	4.36	No	No	0	2	7
438	R:R:H302	R:R:L298	3.86	Yes	No	0	6	6
439	R:R:G303	R:R:P304	4.06	No	Yes	5	4	9
440	R:R:F356	R:R:L309	3.65	Yes	No	1	7	7
441	R:R:F315	R:R:V311	5.24	No	No	0	8	6
442	R:R:L352	R:R:N312	9.61	No	No	0	9	9
443	R:R:F313	R:R:L317	6.09	No	No	0	6	5
444	R:R:F313	R:R:I354	5.02	No	No	0	6	6
445	R:R:F313	R:R:V357	6.55	No	No	0	6	7
446	R:R:L316	R:R:L348	4.15	No	No	0	9	9
447	R:R:I354	R:R:L316	5.71	No	No	0	6	9
448	R:R:N318	R:R:R321	4.82	No	No	0	8	8
449	R:R:T345	R:R:V320	3.17	No	No	0	9	7
450	R:R:R328	R:R:V324	6.54	No	No	0	6	5
451	R:R:E329	R:R:T325	5.64	No	No	0	6	7
452	R:R:M327	R:R:M337	10.11	No	No	0	7	7
453	R:R:M337	R:R:R328	4.96	No	No	0	7	6
454	R:R:E332	R:R:H336	17.23	No	No	0	5	6
455	R:R:E334	R:R:Y338	13.47	No	No	0	6	7
456	R:R:H336	R:R:K340	6.55	No	No	0	6	8
457	R:R:I347	R:R:K343	5.82	No	No	0	8	8
458	R:R:I347	R:R:I390	4.42	No	No	21	8	8
459	R:R:I347	R:R:Y391	3.63	No	Yes	21	8	8
460	R:R:P350	R:R:V349	3.53	No	No	0	9	8
461	R:R:I354	R:R:V349	7.68	No	No	0	6	8
462	R:R:L351	R:R:L352	5.54	No	No	0	9	9
463	R:R:L351	R:R:Y391	18.76	No	Yes	0	9	8
464	R:R:G353	R:R:Q355	4.93	No	Yes	0	9	8
465	R:R:F356	R:R:Q355	9.37	Yes	Yes	1	7	8
466	R:R:L379	R:R:Q355	3.99	No	Yes	0	5	8
467	R:R:Q355	R:R:Q383	11.52	Yes	Yes	1	8	9
468	R:R:F356	R:R:I380	7.54	Yes	No	0	7	6
469	R:R:F356	R:R:Q383	4.68	Yes	Yes	1	7	9
470	R:R:F359	R:R:V358	5.24	No	No	0	6	5
471	R:R:F359	R:R:Y372	4.13	No	Yes	22	6	7
472	R:R:F359	R:R:M376	4.98	No	No	22	6	7
473	R:R:G369	R:R:R362	6	No	Yes	0	4	4
474	R:R:R362	R:R:Y372	9.26	Yes	Yes	0	4	7
475	R:R:D373	R:R:R362	14.29	No	Yes	0	5	4
476	R:R:L368	R:R:P363	9.85	No	No	0	3	7
477	R:R:G369	R:R:P363	6.09	No	No	0	4	7
478	R:R:P363	R:R:Y372	6.95	No	Yes	0	7	7
479	R:R:L368	R:R:N365	6.87	No	No	0	3	4
480	R:R:K370	R:R:Y374	13.14	No	Yes	18	4	6
481	R:R:M376	R:R:Y372	11.97	No	Yes	22	7	7
482	R:R:H377	R:R:H381	9.55	Yes	Yes	0	7	9
483	R:R:H381	R:R:I380	3.98	Yes	No	0	9	6
484	R:R:F382	R:R:F386	4.29	No	No	0	7	5
485	R:R:F385	R:R:F386	6.43	Yes	No	0	5	5
486	R:R:F385	R:R:T389	6.49	Yes	No	0	5	5
487	R:R:F393	R:R:T389	6.49	Yes	No	0	8	5
488	R:R:I390	R:R:Y391	7.25	No	Yes	21	8	8
489	R:R:E397	R:R:N395	3.94	No	No	0	9	9
490	R:R:N395	R:R:V398	8.87	No	No	0	9	9
491	R:R:R404	R:R:T400	3.88	No	No	0	7	4
492	R:R:Q405	R:R:R404	3.5	No	No	0	4	7
493	R:R:F409	R:R:Q408	8.2	Yes	No	0	3	7
494	E:E:I118	E:E:S117	3.1	Yes	No	0	6	4
495	R:R:I192	R:R:V164	3.07	No	No	0	7	4
496	R:R:I221	R:R:V217	3.07	No	No	0	4	3
497	R:R:I248	R:R:V249	3.07	Yes	No	7	7	6
498	R:R:I248	R:R:V322	3.07	Yes	No	0	7	8
499	R:R:I279	R:R:T275	3.04	No	No	0	3	3
500	R:R:K326	R:R:V322	3.04	No	No	0	9	8
501	E:E:A87	E:E:E88	3.02	No	No	0	4	4
502	R:R:M346	R:R:T345	3.01	No	No	0	8	9
503	E:E:G108	E:E:R109	3	No	No	0	9	9
504	R:R:K185	R:R:T182	3	No	No	0	6	5
505	L:L:L16	R:R:V206	2.98	Yes	No	0	0	3
506	R:R:L316	R:R:V320	2.98	No	No	0	9	7
507	L:L:A8	R:R:H377	2.93	No	Yes	0	0	7
508	L:L:A13	R:R:H201	2.93	No	No	0	0	6
509	E:E:D47	E:E:V46	2.92	No	No	0	6	2
510	R:R:I197	R:R:M229	2.92	No	No	0	5	4
511	R:R:N396	R:R:T400	2.92	No	No	0	6	4
512	R:R:G67	R:R:Y65	2.9	No	Yes	0	2	3
513	R:R:D101	R:R:T138	2.89	Yes	No	0	4	2
514	R:R:F386	R:R:P350	2.89	No	No	0	5	9
515	R:R:K340	R:R:M327	2.88	No	No	0	8	7
516	R:R:K340	R:R:K343	2.87	No	No	0	8	8
517	R:R:I153	R:R:L202	2.85	No	No	0	7	7
518	R:R:L323	R:R:M327	2.83	No	No	0	9	7
519	R:R:E332	R:R:T330	2.82	No	No	0	5	5
520	L:L:G33	R:R:W128	2.81	No	Yes	0	0	5
521	R:R:M229	R:R:N194	2.8	No	No	0	4	8
522	R:R:M367	R:R:N365	2.8	No	No	0	4	4
523	E:E:C82	E:E:R37	2.79	No	Yes	0	9	4
524	L:L:A5	R:R:F356	2.77	No	Yes	0	0	7
525	L:L:F15	R:R:A145	2.77	No	No	0	0	4
526	R:R:A278	R:R:F224	2.77	No	Yes	0	6	5
527	R:R:E255	R:R:K256	2.7	No	No	0	6	5
528	R:R:E329	R:R:K326	2.7	No	No	0	6	9
529	R:R:H156	R:R:I199	2.65	Yes	No	0	7	7
530	R:R:E210	R:R:N208	2.63	No	No	0	3	3
531	E:E:V129	R:R:F269	2.62	No	Yes	0	6	3
532	R:R:F314	R:R:V310	2.62	No	No	0	5	4
533	E:E:A70	E:E:W84	2.59	No	Yes	0	8	9
534	R:R:F224	R:R:T274	2.59	Yes	No	0	5	6
535	R:R:F224	R:R:T275	2.59	Yes	No	0	5	3
536	R:R:A278	R:R:W290	2.59	No	Yes	0	6	9
537	R:R:F225	R:R:I221	2.51	No	No	0	5	4
538	R:R:T109	R:R:Y92	2.5	No	No	0	5	4
539	E:E:M76	E:E:R37	2.48	No	Yes	0	6	4
540	E:E:V137	R:R:W261	2.45	No	Yes	0	9	2
541	E:E:I123	R:R:Y299	2.42	No	No	0	9	7
542	E:E:I63	E:E:W59	2.35	Yes	No	0	4	9
543	E:E:R102	R:R:Q60	2.34	No	No	0	4	3
544	E:E:E68	E:E:F44	2.33	No	Yes	4	4	9
545	R:R:F119	R:R:H121	2.26	No	Yes	0	4	4
546	R:R:F224	R:R:F225	2.14	Yes	No	0	5	5
547	E:E:G116	E:E:P115	2.03	No	No	0	4	9
548	R:R:G116	R:R:P70	2.03	No	No	0	9	1
549	R:R:G268	R:R:P270	2.03	No	Yes	0	6	9
550	R:R:C112	R:R:G116	1.96	No	No	0	9	9
551	L:L:P28	L:L:P29	1.95	No	No	0	0	0
552	E:E:C104	E:E:P105	1.88	No	No	0	9	6
553	R:R:G155	R:R:V154	1.84	No	No	0	8	6
554	R:R:A87	R:R:C112	1.81	No	No	0	4	9
555	R:R:P216	R:R:S218	1.78	No	No	0	4	3
556	R:R:G44	R:R:K47	1.74	No	No	0	4	4
557	R:R:G268	R:R:L264	1.71	No	No	0	6	3
558	L:L:N22	R:R:G209	1.7	No	No	0	0	3
559	R:R:G209	R:R:N208	1.7	No	No	0	3	3
560	R:R:A341	R:R:V324	1.7	No	No	0	9	5
561	R:R:C394	R:R:T389	1.69	No	No	0	5	5
562	E:E:T130	R:R:A307	1.68	Yes	No	0	9	3
563	R:R:D113	R:R:G116	1.68	Yes	No	0	5	9
564	R:R:A251	R:R:T246	1.68	No	No	0	6	7
565	R:R:M306	R:R:P360	1.68	No	No	0	4	5
566	R:R:G67	R:R:Q66	1.64	No	No	0	2	1
567	R:R:E68	R:R:G67	1.64	No	No	0	1	2
568	R:R:E68	R:R:G69	1.64	No	No	0	1	1
569	L:L:P29	R:R:N135	1.63	No	Yes	0	0	3
570	R:R:A136	R:R:M133	1.61	No	Yes	0	2	5
571	E:E:V124	E:E:V125	1.6	No	No	0	4	6
572	R:R:V310	R:R:V357	1.6	No	No	0	4	7
573	E:E:L131	R:R:A307	1.58	No	No	0	9	3
574	R:R:A344	R:R:L323	1.58	No	No	0	9	9
575	R:R:I199	R:R:S157	1.55	No	No	0	7	7
576	R:R:I153	R:R:V203	1.54	No	No	0	7	3
577	R:R:I199	R:R:V203	1.54	No	No	0	7	3
578	R:R:I371	R:R:V375	1.54	No	No	0	5	4
579	E:E:C40	E:E:Q43	1.53	No	No	0	9	4
580	R:R:K185	R:R:V171	1.52	No	No	0	6	4
581	E:E:A50	E:E:E49	1.51	No	No	0	5	4
582	L:L:T6	R:R:M306	1.51	Yes	No	0	0	4
583	E:E:G98	E:E:R102	1.5	No	No	0	3	4
584	R:R:K120	R:R:T127	1.5	No	No	0	1	4
585	R:R:L151	R:R:S378	1.5	No	No	0	5	5
586	R:R:L379	R:R:S378	1.5	No	No	0	5	5
587	R:R:L222	R:R:V205	1.49	No	No	0	6	7
588	R:R:L379	R:R:V375	1.49	No	No	0	5	4
589	E:E:L132	E:E:T128	1.47	No	No	0	7	6
590	L:L:N31	L:L:T30	1.46	No	Yes	0	0	0
591	L:L:N31	L:L:T36	1.46	No	Yes	0	0	0
592	L:L:N35	L:L:T36	1.46	No	Yes	0	0	0
593	R:R:A333	R:R:H336	1.46	No	No	0	5	6
594	E:E:I106	R:R:K54	1.45	No	No	0	4	4
595	R:R:I200	R:R:L222	1.43	No	No	0	6	6
596	R:R:E204	R:R:V203	1.43	No	No	0	4	3
597	E:E:T144	R:R:E255	1.41	No	No	0	7	6
598	E:E:P121	E:E:Y120	1.39	No	No	0	8	6
599	E:E:A95	E:E:R91	1.38	No	No	0	4	3
600	E:E:E38	E:E:L41	1.33	No	Yes	0	4	7
601	E:E:H75	E:E:M76	1.31	No	No	0	4	6
602	R:R:D113	R:R:E114	1.3	Yes	No	0	5	2
603	R:R:M48	R:R:R45	1.24	No	No	0	6	7
604	R:R:M49	R:R:R45	1.24	No	No	0	4	7
605	R:R:M337	R:R:Y338	1.2	No	No	0	7	7
606	R:R:E114	R:R:Y111	1.12	No	No	0	2	4
607	E:E:E78	E:E:W74	1.09	No	No	0	1	1
608	R:R:F409	R:R:W406	1	Yes	No	0	3	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	E:E:R37	4.86571	7	4	4
2	E:E:L41	4.9825	4	0	7
3	E:E:F44	7.368	5	4	9
4	E:E:I63	5.42	4	12	4
5	E:E:Y66	8.2875	4	0	9
6	E:E:L69	10.86	4	4	8
7	E:E:T73	4.995	4	4	9
8	E:E:W84	5.868	5	0	9
9	E:E:F92	6.664	5	4	8
10	E:E:F93	7.88	4	4	9
11	E:E:H97	8.555	4	13	9
12	E:E:Y100	17.705	4	11	9
13	E:E:D113	5.666	5	3	9
14	E:E:P114	6.9925	4	3	9
15	E:E:I118	3.456	5	3	6
16	E:E:T130	4.7625	4	5	9
17	L:L:T6	5.25833	6	1	0
18	L:L:L16	4.86	6	8	0
19	L:L:L23	7.5225	4	8	0
20	L:L:T30	4.188	5	2	0
21	L:L:T36	3.7675	4	0	0
22	L:L:Y37	8.405	4	0	0
23	L:L:?38	7.7275	4	2	0
24	R:R:Y53	7.1775	4	13	1
25	R:R:Y56	7.652	5	0	3
26	R:R:L62	6.6975	4	10	3
27	R:R:Y65	11.8625	4	0	3
28	R:R:W76	7.554	5	15	8
29	R:R:D77	5.618	5	2	9
30	R:R:W79	9.82714	7	2	6
31	R:R:L80	5.914	5	2	5
32	R:R:W82	7.59833	6	2	9
33	R:R:C95	5.015	4	2	9
34	R:R:Y98	8.838	5	2	4
35	R:R:F99	9.595	4	2	5
36	R:R:D101	5.0175	4	0	4
37	R:R:F102	7.81833	6	2	4
38	R:R:E106	5.4275	4	2	4
39	R:R:V108	6.0475	4	2	7
40	R:R:D113	3.9725	4	0	5
41	R:R:W118	14.3975	4	0	9
42	R:R:H121	7.556	5	2	4
43	R:R:W128	8.3675	4	2	5
44	R:R:S129	6.018	5	2	7
45	R:R:Y131	9.92333	6	2	5
46	R:R:M133	6.145	4	2	5
47	R:R:N135	6.12	4	0	3
48	R:R:Y149	6.8775	4	8	5
49	R:R:H156	9.1225	4	0	7
50	R:R:S166	5.2175	4	0	9
51	R:R:F170	7.2375	4	0	8
52	R:R:F173	5.08833	6	19	7
53	R:R:L176	6.3075	4	0	9
54	R:R:Q179	7.3325	4	1	7
55	R:R:R180	4.655	4	20	9
56	R:R:F188	5.076	5	0	8
57	R:R:Y191	9.67	6	1	8
58	R:R:L211	5.7775	4	6	1
59	R:R:C219	4.41	4	6	9
60	R:R:F224	2.5225	4	0	5
61	R:R:Y234	8.75	6	1	7
62	R:R:F235	4.92	5	5	5
63	R:R:W236	8.73	7	1	9
64	R:R:M237	4.8075	4	1	9
65	R:R:L238	5.815	4	0	8
66	R:R:I242	4.994	5	0	7
67	R:R:Y243	8.512	5	1	8
68	R:R:H245	14.245	4	7	8
69	R:R:I248	3.71	4	7	7
70	R:R:Q257	7.908	5	1	5
71	R:R:W261	9.125	4	9	2
72	R:R:Y262	6.15143	7	1	7
73	R:R:L265	4.8775	4	5	7
74	R:R:W267	7.8925	4	1	9
75	R:R:F269	6.1	7	5	3
76	R:R:P270	4.392	5	5	9
77	R:R:H277	8.662	5	3	7
78	R:R:R281	8.27167	6	3	7
79	R:R:F285	9.48667	6	3	6
80	R:R:W290	12.01	5	3	9
81	R:R:T295	10.815	4	3	4
82	R:R:L297	5.418	5	3	4
83	R:R:H302	7.028	5	1	6
84	R:R:P304	4.585	4	5	9
85	R:R:Q355	7.4525	4	1	8
86	R:R:F356	6.80571	7	1	7
87	R:R:R362	8.5925	4	0	4
88	R:R:Y372	8.0775	4	22	7
89	R:R:Y374	7.825	4	18	6
90	R:R:H377	7.3	4	0	7
91	R:R:H381	7.142	5	0	9
92	R:R:Q383	8.7925	4	1	9
93	R:R:F385	9.1325	4	0	5
94	R:R:Y391	8.5	4	21	8
95	R:R:F393	5.1825	4	0	8
96	R:R:F409	4.98	4	19	3
97	H:H:?2	11.514	5	2	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	E:E:F92	E:E:L41	17.1396	10.96	Yes	Yes	0	8	7
2	E:E:R37	E:E:T73	10.88	3.88	Yes	Yes	4	4	9
3	E:E:E68	E:E:F44	13.5459	2.33	No	Yes	4	4	9
4	E:E:F44	E:E:L69	10.2437	21.92	Yes	Yes	4	9	8
5	E:E:F92	E:E:L69	10.0258	7.31	Yes	Yes	4	8	8
6	E:E:T73	E:E:W84	42.1117	4.85	Yes	Yes	0	9	9
7	E:E:P85	E:E:W84	47.9257	6.76	No	Yes	0	9	9
8	E:E:P85	L:L:Y37	50.8286	5.56	No	Yes	0	9	0
9	L:L:Y37	R:R:W79	26.7909	14.47	Yes	Yes	0	0	6
10	R:R:M48	R:R:W79	10.9867	3.49	No	Yes	2	6	6
11	R:R:M48	R:R:R45	10.5522	1.24	No	No	0	6	7
12	R:R:M49	R:R:R45	10.031	1.24	No	No	0	4	7
13	E:E:D90	R:R:Y56	10.5383	9.2	No	Yes	0	9	3
14	E:E:D90	R:R:T75	10.7896	5.78	No	No	0	9	5
15	L:L:Y37	R:R:D77	26.3044	3.45	Yes	Yes	0	0	9
16	R:R:D77	R:R:S129	13.1213	5.89	Yes	Yes	2	9	7
17	L:L:?38	R:R:S129	32.1453	3.72	Yes	Yes	2	0	7
18	L:L:?38	R:R:W128	90.8897	14.09	Yes	Yes	2	0	5
19	H:H:?2	R:R:W128	90.4298	10.22	Yes	Yes	2	0	5
20	H:H:?2	R:R:M133	92.6723	7.61	Yes	Yes	2	0	5
21	R:R:E106	R:R:M133	92.655	5.41	Yes	Yes	2	4	5
22	R:R:D103	R:R:E106	93.1139	3.9	No	Yes	0	3	4
23	R:R:D103	R:R:P104	93.3343	4.83	No	No	0	3	3
24	R:R:E294	R:R:P104	93.5522	3.14	No	No	0	3	3
25	L:L:K1	R:R:E294	93.6602	6.75	No	No	0	0	3
26	L:L:K1	L:L:R11	93.5175	6.19	No	No	14	0	0
27	L:L:N3	L:L:R11	94.086	4.82	No	No	0	0	0
28	L:L:N3	R:R:R362	94.2953	4.82	No	Yes	0	0	4
29	R:R:D373	R:R:R362	95.6904	14.29	No	Yes	0	5	4
30	R:R:D373	R:R:L148	95.7854	5.43	No	No	0	5	5
31	R:R:H377	R:R:L148	96.2512	10.29	Yes	No	0	7	5
32	R:R:H377	R:R:H381	98.0298	9.55	Yes	Yes	0	7	9
33	R:R:H381	R:R:I380	99.9561	3.98	Yes	No	0	9	6
34	R:R:F356	R:R:I380	100	7.54	Yes	No	0	7	6
35	L:L:T6	R:R:F356	12.7387	5.19	Yes	Yes	1	0	7
36	L:L:T6	R:R:H302	10.2842	8.21	Yes	Yes	1	0	6
37	R:R:H302	R:R:L298	11.8069	3.86	Yes	No	0	6	6
38	R:R:H277	R:R:L298	11.5605	3.86	Yes	No	0	7	6
39	R:R:D77	R:R:Y131	13.2064	5.75	Yes	Yes	2	9	5
40	L:L:?38	R:R:Y131	35.6394	5.8	Yes	Yes	2	0	5
41	R:R:W79	R:R:Y131	21.9419	23.15	Yes	Yes	2	6	5
42	L:L:T36	R:R:W79	21.0394	4.85	Yes	Yes	0	0	6
43	L:L:?38	L:L:T36	23.2479	7.3	Yes	Yes	0	0	0
44	R:R:F356	R:R:Y234	22.7735	14.44	Yes	Yes	1	7	7
45	R:R:M237	R:R:Y234	27.2938	3.59	Yes	Yes	1	9	7
46	R:R:M237	R:R:N233	46.5178	4.21	Yes	No	1	9	9
47	R:R:N233	R:R:T190	74.9704	8.77	No	No	1	9	9
48	R:R:T190	R:R:W236	56.1283	6.06	No	Yes	1	9	9
49	R:R:C239	R:R:W236	32.2218	7.84	No	Yes	0	7	9
50	R:R:C239	R:R:L265	17.8084	4.76	No	Yes	0	7	7
51	E:E:T130	R:R:F235	10.1663	3.89	Yes	Yes	5	9	5
52	E:E:T130	R:R:P304	13.4085	6.99	Yes	Yes	5	9	9
53	R:R:F356	R:R:Q383	65.1284	4.68	Yes	Yes	1	7	9
54	R:R:M237	R:R:Q383	23.3856	5.44	Yes	Yes	1	9	9
55	R:R:Q383	R:R:Y191	44.14	13.53	Yes	Yes	1	9	8
56	R:R:N233	R:R:Y191	28.9746	15.12	No	Yes	1	9	8
57	R:R:T190	R:R:W267	18.3547	3.64	No	Yes	1	9	9
58	R:R:C232	R:R:W267	18.5713	5.22	No	Yes	0	8	9
59	R:R:C232	R:R:P270	17.3281	7.53	No	Yes	0	8	9
60	R:R:M187	R:R:Y191	11.1573	8.38	No	Yes	0	8	8
61	R:R:E240	R:R:M187	10.8948	8.12	No	No	0	9	8
62	R:R:L183	R:R:W236	20.2094	4.56	No	Yes	1	8	9
63	R:R:L183	R:R:Y262	14.1515	5.86	No	Yes	1	8	7
64	R:R:I242	R:R:Y262	18.8582	4.84	Yes	Yes	0	7	7
65	R:R:C239	R:R:Y262	14.3985	5.38	No	Yes	0	7	7
66	R:R:F315	R:R:I242	17.6032	3.77	No	Yes	0	8	7
67	R:R:F315	R:R:H245	15.2641	26.02	No	Yes	0	8	8
68	L:L:L12	R:R:H377	14.6684	6.43	No	Yes	0	0	7
69	L:L:L12	L:L:L16	14.3443	4.15	No	Yes	0	0	0
70	R:R:T75	R:R:W118	11.0474	8.49	No	Yes	0	5	9
71	R:R:K110	R:R:S129	14.6575	9.18	No	Yes	2	8	7
72	R:R:K110	R:R:W118	15.0896	22.05	No	Yes	0	8	9
73	R:R:V387	R:R:Y191	19.2884	6.31	No	Yes	0	9	8
74	R:R:F188	R:R:V387	19.0553	3.93	Yes	No	0	8	9
75	E:E:F92	E:E:T73	28.339	6.49	Yes	Yes	4	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
E:E:P85	E:E:W84	6.76	0	No	Yes	9	9	1	2
E:E:P85	L:L:Y37	5.56	0	No	Yes	9	0	1	0
E:E:P85	R:R:R126	4.32	0	No	No	9	4	1	2
L:L:K1	R:R:V293	4.55	14	No	No	0	6	0	1
L:L:K1	R:R:E294	6.75	14	No	No	0	3	0	1
L:L:C2	R:R:Y299	5.38	1	No	No	0	7	0	1
L:L:N3	R:R:W361	18.08	0	No	No	0	4	0	1
L:L:N3	R:R:R362	4.82	0	No	Yes	0	4	0	1
L:L:T6	R:R:Y234	8.74	1	Yes	Yes	0	7	0	1
L:L:T6	R:R:H302	8.21	1	Yes	Yes	0	6	0	1
L:L:T6	R:R:V305	4.76	1	Yes	No	0	7	0	1
L:L:T6	R:R:F356	5.19	1	Yes	Yes	0	7	0	1
L:L:C7	R:R:H302	10.32	1	No	Yes	0	6	0	1
L:L:T9	R:R:H381	4.11	0	No	Yes	0	9	0	1
L:L:Q10	R:R:H226	3.71	1	No	No	0	6	0	1
L:L:Q10	R:R:M230	5.44	1	No	No	0	6	0	1
L:L:Q10	R:R:H302	6.18	1	No	Yes	0	6	0	1
L:L:R11	R:R:V293	3.92	14	No	No	0	6	0	1
L:L:L12	R:R:H377	6.43	0	No	Yes	0	7	0	1
L:L:N14	R:R:V293	4.43	0	No	No	0	6	0	1
L:L:F15	R:R:K141	18.61	0	No	No	0	3	0	1
L:L:L16	R:R:A145	3.15	8	Yes	No	0	4	0	1
L:L:L16	R:R:Y149	4.69	8	Yes	Yes	0	5	0	1
L:L:V17	R:R:V206	4.81	6	No	No	0	3	0	1
L:L:V17	R:R:V212	4.81	6	No	No	0	3	0	1
L:L:V17	R:R:L291	4.47	6	No	No	0	6	0	1
L:L:R18	R:R:P104	8.65	0	No	No	0	3	0	1
L:L:S20	R:R:Y146	3.82	8	No	No	0	2	0	1
L:L:L23	R:R:Y146	5.86	8	Yes	No	0	2	0	1
L:L:L23	R:R:Y149	7.03	8	Yes	Yes	0	5	0	1
L:L:T30	R:R:F99	5.19	2	Yes	Yes	0	5	0	1
L:L:T30	R:R:D101	7.23	2	Yes	Yes	0	4	0	1
L:L:T30	R:R:F102	3.89	2	Yes	Yes	0	4	0	1
L:L:V32	R:R:N135	8.87	0	No	Yes	0	3	0	1
L:L:S34	R:R:E123	10.06	0	No	No	0	4	0	1
L:L:S34	R:R:N124	5.96	0	No	No	0	5	0	1
L:L:T36	R:R:W79	4.85	0	Yes	Yes	0	6	0	1
L:L:Y37	R:R:D77	3.45	0	Yes	Yes	0	9	0	1
L:L:Y37	R:R:G78	10.14	0	Yes	No	0	5	0	1
L:L:Y37	R:R:W79	14.47	0	Yes	Yes	0	6	0	1
L:L:?38	R:R:W128	14.09	2	Yes	Yes	0	5	0	1
L:L:?38	R:R:S129	3.72	2	Yes	Yes	0	7	0	1
L:L:?38	R:R:Y131	5.8	2	Yes	Yes	0	5	0	1
R:R:M48	R:R:W79	3.49	2	No	Yes	6	6	2	1
R:R:M48	R:R:Y98	9.58	2	No	Yes	6	4	2	2
R:R:D77	R:R:L80	4.07	2	Yes	Yes	9	5	1	2
R:R:D77	R:R:W82	8.93	2	Yes	Yes	9	9	1	2
R:R:D77	R:R:S129	5.89	2	Yes	Yes	9	7	1	1
R:R:D77	R:R:Y131	5.75	2	Yes	Yes	9	5	1	1
R:R:W79	R:R:Y98	5.79	2	Yes	Yes	6	4	1	2
R:R:F99	R:R:W79	13.03	2	Yes	Yes	5	6	1	1
R:R:F102	R:R:W79	4.01	2	Yes	Yes	4	6	1	1
R:R:W79	R:R:Y131	23.15	2	Yes	Yes	6	5	1	1
R:R:L80	R:R:V108	4.47	2	Yes	Yes	5	7	2	2
R:R:L80	R:R:Y131	5.86	2	Yes	Yes	5	5	2	1
R:R:V108	R:R:W82	3.68	2	Yes	Yes	7	9	2	2
R:R:K110	R:R:W82	18.57	2	No	Yes	8	9	2	2
R:R:S129	R:R:W82	4.94	2	Yes	Yes	7	9	1	2
R:R:C95	R:R:F102	5.59	2	Yes	Yes	9	4	2	1
R:R:C95	R:R:V108	3.42	2	Yes	Yes	9	7	2	2
R:R:C134	R:R:C95	7.28	2	No	Yes	9	9	2	2
R:R:F99	R:R:Y98	5.16	2	Yes	Yes	5	4	1	2
R:R:F102	R:R:F99	15	2	Yes	Yes	4	5	1	1
R:R:D101	R:R:P100	3.22	0	Yes	No	4	4	1	2
R:R:D101	R:R:N135	6.73	0	Yes	Yes	4	3	1	1
R:R:C134	R:R:F102	11.17	2	No	Yes	9	4	2	1
R:R:F102	R:R:N135	7.25	2	Yes	Yes	4	3	1	1
R:R:D103	R:R:P104	4.83	0	No	No	3	3	2	1
R:R:E294	R:R:P104	3.14	0	No	No	3	3	1	1
R:R:V108	R:R:Y131	12.62	2	Yes	Yes	7	5	2	1
R:R:K110	R:R:S129	9.18	2	No	Yes	8	7	2	1
R:R:E123	R:R:H121	18.46	0	No	Yes	4	4	1	2
R:R:H121	R:R:W128	6.35	2	Yes	Yes	4	5	2	1
H:H:?2	R:R:H121	4.61	2	Yes	Yes	0	4	2	2
H:H:?2	R:R:W128	10.22	2	Yes	Yes	0	5	2	1
R:R:S129	R:R:Y131	6.36	2	Yes	Yes	7	5	1	1
R:R:L142	R:R:Y146	9.38	0	No	No	2	2	2	1
R:R:D373	R:R:L148	5.43	0	No	No	5	5	2	2
R:R:H377	R:R:L148	10.29	0	Yes	No	7	5	1	2
R:R:Y149	R:R:Y150	9.93	8	Yes	No	5	4	1	2
R:R:L202	R:R:Y149	5.86	0	No	Yes	7	5	2	1
R:R:A152	R:R:H381	7.32	0	No	Yes	7	9	2	1
R:R:H156	R:R:I198	11.93	0	Yes	No	7	7	2	2
R:R:H156	R:R:H381	10.75	0	Yes	Yes	7	9	2	1
R:R:H226	R:R:I198	3.98	0	No	No	6	7	1	2
R:R:H201	R:R:V205	12.45	0	No	No	6	7	1	2
R:R:P207	R:R:V206	5.3	0	No	No	3	3	2	1
R:R:C289	R:R:V212	5.12	6	No	No	9	3	2	1
R:R:L291	R:R:V212	4.47	6	No	No	6	3	1	1
R:R:M230	R:R:Y234	5.99	1	No	Yes	6	7	1	1
R:R:H302	R:R:M230	6.57	1	Yes	No	6	6	1	1
R:R:M237	R:R:Y234	3.59	1	Yes	Yes	9	7	2	1
R:R:V305	R:R:Y234	13.88	1	No	Yes	7	7	1	1
R:R:L309	R:R:Y234	5.86	1	No	Yes	7	7	2	1
R:R:F356	R:R:Y234	14.44	1	Yes	Yes	7	7	1	1
R:R:M237	R:R:Q383	5.44	1	Yes	Yes	9	9	2	2
R:R:C289	R:R:L291	3.17	6	No	No	9	6	2	1
R:R:H296	R:R:Y299	4.36	0	No	No	2	7	2	1
R:R:H302	R:R:L298	3.86	1	Yes	No	6	6	1	2
R:R:F356	R:R:L309	3.65	1	Yes	No	7	7	1	2
R:R:F356	R:R:Q355	9.37	1	Yes	Yes	7	8	1	2
R:R:Q355	R:R:Q383	11.52	1	Yes	Yes	8	9	2	2
R:R:F356	R:R:I380	7.54	1	Yes	No	7	6	1	2
R:R:F356	R:R:Q383	4.68	1	Yes	Yes	7	9	1	2
R:R:G369	R:R:R362	6	0	No	Yes	4	4	2	1
R:R:R362	R:R:Y372	9.26	0	Yes	Yes	4	7	1	2
R:R:D373	R:R:R362	14.29	0	No	Yes	5	4	2	1
R:R:H377	R:R:H381	9.55	0	Yes	Yes	7	9	1	1
R:R:H381	R:R:I380	3.98	0	Yes	No	9	6	1	2
L:L:L16	R:R:V206	2.98	8	Yes	No	0	3	0	1
L:L:A8	R:R:H377	2.93	0	No	Yes	0	7	0	1
L:L:A13	R:R:H201	2.93	0	No	No	0	6	0	1
R:R:D101	R:R:T138	2.89	0	Yes	No	4	2	1	2
L:L:G33	R:R:W128	2.81	0	No	Yes	0	5	0	1
L:L:A5	R:R:F356	2.77	0	No	Yes	0	7	0	1
L:L:F15	R:R:A145	2.77	0	No	No	0	4	0	1
E:E:I123	R:R:Y299	2.42	0	No	No	9	7	2	1
L:L:N22	R:R:G209	1.7	0	No	No	0	3	0	1
R:R:G209	R:R:N208	1.7	0	No	No	3	3	1	2
R:R:M306	R:R:P360	1.68	0	No	No	4	5	1	2
L:L:P29	R:R:N135	1.63	0	No	Yes	0	3	0	1
L:L:T6	R:R:M306	1.51	1	Yes	No	0	4	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7TYF_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.14
Number of Linked Nodes	490
Number of Links	608
Number of Hubs	97
Number of Links mediated by Hubs	348
Number of Communities	22
Number of Nodes involved in Communities	151
Number of Links involved in Communities	209

Path Summary
Number Of Nodes in MetaPath	76
Number Of Links MetaPath	75
Number of Shortest Paths	486903
Length Of Smallest Path	3
Average Path Length	26.4888
Length of Longest Path	48
Minimum Path Strength	1.21
Average Path Strength	6.87495
Maximum Path Strength	22.125
Minimum Path Correlation	0.7
Average Path Correlation	0.96765
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	2.7027
Average % Of Corr. Nodes	46.3097
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	50.1318
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development
Gene Ontology	Biological Process	• multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • calcitonin family binding • calcitonin gene-related peptide binding • amide binding • binding • peptide hormone binding • hormone binding • molecular transducer activity • coreceptor activity • signaling receptor activity • calcitonin family receptor activity • peptide receptor activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • transmembrane signaling receptor activity • calcitonin gene-related peptide receptor activity • amylin receptor activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • cellular localization • establishment of protein localization • nitrogen compound transport • transport • intracellular transport • establishment of localization • localization • protein transport • establishment of localization in cell • macromolecule localization • intracellular protein localization • intracellular protein transport • regulation of signaling • regulation of signal transduction • regulation of response to stimulus • regulation of cell communication • regulation of G protein-coupled receptor signaling pathway • import into cell • receptor internalization • receptor-mediated endocytosis • endocytosis • vesicle-mediated transport • developmental process • multicellular organismal process • blood vessel morphogenesis • tube development • angiogenesis • vasculature development • circulatory system development • anatomical structure morphogenesis • multicellular organism development • tube morphogenesis • anatomical structure formation involved in morphogenesis • anatomical structure development • blood vessel development • system development • calcitonin family receptor signaling pathway • calcitonin gene-related peptide receptor signaling pathway • amylin receptor signaling pathway • monoatomic ion transport • monoatomic cation transport • calcium ion transport • metal ion transport • protein localization to cell periphery • protein localization to plasma membrane • localization within membrane • protein localization to membrane • amylin receptor 1 signaling pathway • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to endogenous stimulus • response to chemical • cellular response to hormone stimulus • receptor complex • cell surface • plasma membrane signaling receptor complex • G protein-coupled receptor complex • CGRP receptor complex • calcitonin family receptor complex • protein binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to monoamine stimulus • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • signaling receptor binding • molecular function activator activity • molecular function regulator activity • signaling receptor regulator activity • receptor ligand activity • signaling receptor activator activity • hormone activity • lipid binding • identical protein binding • positive regulation of cell communication • positive regulation of signal transduction • positive regulation of biological process • intracellular signal transduction • positive regulation of response to stimulus • regulation of intracellular signal transduction • intracellular signaling cassette • regulation of calcium-mediated signaling • positive regulation of calcium-mediated signaling • positive regulation of cellular process • positive regulation of intracellular signal transduction • calcium-mediated signaling • positive regulation of signaling • behavior • eating behavior • feeding behavior • myeloid leukocyte differentiation • regulation of leukocyte differentiation • cellular developmental process • regulation of developmental process • negative regulation of biological process • cell development • regulation of cell differentiation • regulation of cell development • regulation of osteoclast differentiation • cell differentiation • osteoclast differentiation • negative regulation of cellular process • regulation of immune system process • regulation of multicellular organismal process • negative regulation of cell differentiation • negative regulation of hemopoiesis • regulation of multicellular organismal development • negative regulation of leukocyte differentiation • hemopoiesis • regulation of myeloid cell differentiation • negative regulation of developmental process • regulation of myeloid leukocyte differentiation • negative regulation of myeloid cell differentiation • negative regulation of osteoclast differentiation • negative regulation of myeloid leukocyte differentiation • negative regulation of cell development • myeloid cell differentiation • negative regulation of immune system process • immune system process • regulation of hemopoiesis • negative regulation of multicellular organismal process • leukocyte differentiation • monosaccharide metabolic process • carbohydrate metabolic process • hexose metabolic process • small molecule metabolic process • metabolic process • primary metabolic process • glucose metabolic process • negative regulation of tissue remodeling • homeostatic process • negative regulation of bone remodeling • regulation of bone remodeling • tissue homeostasis • regulation of tissue remodeling • regulation of bone resorption • bone resorption • negative regulation of bone resorption • multicellular organismal-level homeostasis • tissue remodeling • bone remodeling • anatomical structure homeostasis • amylin receptor 2 signaling pathway • system process • sensory perception • nervous system process • sensory perception of pain • positive regulation of cAMP/PKA signal transduction • cAMP/PKA signal transduction • regulation of cAMP/PKA signal transduction • amylin receptor 3 signaling pathway • intracellular vesicle • endomembrane system • cytoplasmic vesicle • secretory granule • secretory vesicle • somatodendritic compartment • cell body • neuronal cell body • amyloid-beta binding • peptide binding • calcitonin receptor activity • calcitonin binding • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • catabolic process • RNA metabolic process • macromolecule catabolic process • regulation of primary metabolic process • nucleobase-containing compound metabolic process • post-transcriptional regulation of gene expression • regulation of RNA metabolic process • regulation of mRNA catabolic process • regulation of nucleobase-containing compound metabolic process • RNA catabolic process • negative regulation of macromolecule metabolic process • regulation of biosynthetic process • mRNA catabolic process • negative regulation of metabolic process • regulation of macromolecule metabolic process • regulation of catabolic process • gene expression • mRNA metabolic process • macromolecule biosynthetic process • nucleic acid metabolic process • nucleobase-containing compound catabolic process • regulation of mRNA stability • regulation of gene expression • negative regulation of gene expression • biosynthetic process • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • regulation of RNA stability • nucleic acid catabolic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • regulation of mRNA metabolic process • regulation of metabolic process • positive regulation of ERK1 and ERK2 cascade • positive regulation of MAPK cascade • regulation of MAPK cascade • MAPK cascade • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of macromolecule biosynthetic process • positive regulation of metabolic process • positive regulation of gene expression • positive regulation of biosynthetic process • positive regulation of macromolecule metabolic process • regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • phosphatidylinositol 3-kinase/protein kinase B signal transduction • response to corticosteroid • response to steroid hormone • response to glucocorticoid • response to amyloid-beta • cell surface receptor signaling pathway • ossification • regulation of ossification • negative regulation of ossification • amylin receptor complex • amylin receptor complex 3 • amylin receptor complex 2 • amylin receptor complex 1 • axon • acrosomal vesicle • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • skin development • skin epidermis development • hair follicle development • molting cycle • ectodermal placode development • hair cycle process • sensory perception of chemical stimulus • sensory perception of smell • response to peptide hormone • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • skeletal system development • bone development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • adaptive thermogenesis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • regulation of localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • hormone secretion • protein localization to extracellular region • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • regulation of peptide hormone secretion • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • cell-cell signaling • regulation of protein transport • protein secretion • regulation of protein secretion • regulation of secretion • peptide transport • regulation of insulin secretion • peptide hormone secretion • hormone transport • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • inflammatory response to antigenic stimulus • regulation of response to stress • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • trans-Golgi network
SCOP2	Domain Identifier	• RAMP1-like • Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• RAMP1-like • Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	NH2
PDB Residues	L:L:?38
Environment Details	Open EMBL-EBI Page
Code	NH2
Name	AMINO GROUP
Synonyms
Identifier
Formula	H2 N
Molecular Weight	16.023
SMILES
PubChem	123329
Formal Charge	0
Total Atoms	3
Total Chiral Atoms	0
Total Bonds	2
Total Aromatic Bonds	0


Code	NAG
PDB Residues	H:H:?1 H:H:?2
Environment Details	Open EMBL-EBI Page
Code	NAG
Name	N-Acetylglucosamine
Synonyms	N-Acetylglucosamine
Identifier
Formula	C8 H15 N O6
Molecular Weight	221.208
SMILES
PubChem	24139
Formal Charge	0
Total Atoms	30
Total Chiral Atoms	5
Total Bonds	30
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	E
Protein	RAMP1
UniProt	O60894
Sequence	>7TYF_nogp_Chain_E G A L L R E L C L T Q F Q V D M E A V G E T L W C D W G R T I R S Y R E L A D C T W H M A E K L G C F W P N A E V D R F F L A V H G R Y F R S C P I S G R A V R D P P G S I L Y P F I V V P I T V T L L V T A L V V W Q S K R T Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	R
Protein	Receptor
UniProt	P30988
Sequence	>7TYF_nogp_Chain_R V G R K K M M D A Q Y K C Y D R M Q Q L P A Y Q G E G P Y C N R T W D G W L C W D D T P A G V L S Y Q F C P D Y F P D F D P S E K V T K Y C D E K G V W F K H P E N N R T W S N Y T M C N A F T P E K L K N A Y V L Y Y L A I V G H S L S I F T L V I S L G I F V F F R S L G C Q R V T L H K N M F L T Y I L N S M I I I I H L V E V V P N G E L V R R D P V S C K I L H F F H Q Y M M A C N Y F W M L C E G I Y L H T L I V V A V F T E K Q R L R W Y Y L L G W G F P L V P T T I H A I T R A V Y F N D N C W L S V E T H L L Y I I H G P V M A A L V V N F F F L L N I V R V L V T K M R E T H E A E S H M Y L K A V K A T M I L V P L L G I Q F V V F P W R P S N K M L G K I Y D Y V M H S L I H F Q G F F V A T I Y C F C N N E V Q T T V K R Q W A Q F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9AUC	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Calcitonin gene-related peptide-1	-	Gs/β1/γ2; RAMP1	2.4	2024-04-24	doi.org/10.1021/acs.biochem.4c00114
	9AUC (No Gprot)	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Calcitonin gene-related peptide-1	-		2.4	2024-04-24	doi.org/10.1021/acs.biochem.4c00114
	7TYF	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Amylin	-	Gs/β1/γ2; RAMP1	2.2	2022-03-23	doi.org/10.1126/science.abm9609
	7TYF (No Gprot)	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Amylin	-		2.2	2022-03-23	doi.org/10.1126/science.abm9609
	7TYW	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Calcitonin-1	-	Gs/β1/γ2; RAMP1	3	2022-03-23	doi.org/10.1126/science.abm9609
	7TYW (No Gprot)	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Calcitonin-1	-		3	2022-03-23	doi.org/10.1126/science.abm9609
	9BLW	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Cagrilintide backbone (non-acylated)	-	Gs/β1/γ2; RAMP1	3.2	2025-04-16	To be published
	9BLW (No Gprot)	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Cagrilintide backbone (non-acylated)	-		3.2	2025-04-16	To be published
	9BP3	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Cagrilintide	-	Gs/β1/γ2; RAMP1	2.2	2025-04-23	To be published
	9BP3 (No Gprot)	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Cagrilintide	-		2.2	2025-04-23	To be published

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