psnGPCR

Press and hold down the left mouse button and move the mouse to rotate.
Press and hold down the central mouse button and move the mouse to translate.
Use the mouse wheel to zoom in or out.
Click on any atom on your molecule and the corresponding residue label will be placed beneath the viewer.

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	L:L:K2	10.11	No	Yes	1	0	0
2	L:L:?1	L:L:?102	17.81	No	No	1	0	0
3	L:L:?1	R:R:H296	3.46	No	No	1	0	2
4	L:L:K2	L:L:N4	5.6	Yes	No	0	0	0
5	L:L:E15	L:L:K2	4.05	Yes	Yes	1	0	0
6	L:L:K2	R:R:E294	13.5	Yes	No	1	0	3
7	L:L:C3	L:L:T5	3.38	Yes	No	0	0	0
8	L:L:C3	L:L:C8	7.28	Yes	Yes	1	0	0
9	L:L:C3	L:L:R12	5.57	Yes	No	1	0	0
10	L:L:C3	R:R:V293	3.42	Yes	No	1	0	6
11	L:L:C3	R:R:L298	3.17	Yes	No	1	0	6
12	L:L:C3	R:R:H302	2.95	Yes	No	1	0	6
13	L:L:N4	R:R:W361	6.78	No	No	0	0	4
14	L:L:T5	L:L:T7	3.14	No	Yes	0	0	0
15	L:L:A6	R:R:F356	5.55	No	Yes	0	0	7
16	L:L:A6	R:R:M376	3.22	No	No	0	0	7
17	L:L:T7	R:R:Y234	8.74	Yes	Yes	1	0	7
18	L:L:T7	R:R:H302	10.95	Yes	No	1	0	6
19	L:L:T7	R:R:V305	3.17	Yes	No	1	0	7
20	L:L:T7	R:R:F356	3.89	Yes	Yes	1	0	7
21	L:L:C8	L:L:Q11	6.1	Yes	Yes	1	0	0
22	L:L:C8	L:L:R12	4.18	Yes	No	1	0	0
23	L:L:C8	R:R:H302	8.85	Yes	No	1	0	6
24	L:L:A9	R:R:H377	2.93	No	Yes	0	0	7
25	L:L:T10	R:R:H381	6.85	No	Yes	0	0	9
26	L:L:Q11	R:R:H226	4.95	Yes	Yes	1	0	6
27	L:L:Q11	R:R:Q227	5.12	Yes	Yes	1	0	7
28	L:L:Q11	R:R:M230	6.8	Yes	No	1	0	6
29	L:L:L13	R:R:H377	5.14	No	Yes	0	0	7
30	L:L:A14	R:R:H201	2.93	No	Yes	0	0	6
31	L:L:E15	L:L:H19	8.62	Yes	No	0	0	0
32	L:L:E15	R:R:V293	5.7	Yes	No	1	0	6
33	L:L:E15	R:R:E294	3.81	Yes	No	1	0	3
34	L:L:F16	L:L:S20	5.28	Yes	No	0	0	0
35	L:L:F16	R:R:D103	3.58	Yes	Yes	0	0	3
36	L:L:F16	R:R:K141	4.96	Yes	No	0	0	3
37	L:L:L17	R:R:Y149	5.86	No	Yes	0	0	5
38	L:L:H19	L:L:R18	5.64	No	No	0	0	0
39	L:L:R18	R:R:V212	7.85	No	No	0	0	3
40	L:L:R18	R:R:L291	9.72	No	No	0	0	6
41	L:L:S20	R:R:L142	6.01	No	No	0	0	2
42	L:L:F24	L:L:S21	5.28	Yes	No	0	0	0
43	L:L:G25	L:L:N22	5.09	No	No	0	0	0
44	L:L:L28	L:L:N22	6.87	No	No	0	0	0
45	L:L:F24	R:R:Y146	4.13	Yes	No	0	0	2
46	L:L:F24	R:R:Y149	5.16	Yes	Yes	0	0	5
47	L:L:F24	R:R:P207	5.78	Yes	No	0	0	3
48	L:L:G25	L:L:P26	4.06	No	No	0	0	0
49	L:L:P30	R:R:D101	3.22	No	No	0	0	4
50	L:L:T31	R:R:F99	6.49	No	Yes	2	0	5
51	L:L:T31	R:R:F102	6.49	No	Yes	2	0	4
52	L:L:T31	R:R:N135	2.92	No	Yes	2	0	3
53	L:L:G34	L:L:N32	5.09	No	No	0	0	0
54	L:L:N32	L:L:N36	6.81	No	No	0	0	0
55	L:L:N32	L:L:T37	4.39	No	No	0	0	0
56	L:L:V33	R:R:T132	4.76	No	No	0	0	6
57	L:L:V33	R:R:N135	7.39	No	Yes	0	0	3
58	L:L:G34	R:R:W128	4.22	No	No	0	0	5
59	L:L:N36	L:L:S35	2.98	No	Yes	0	0	0
60	L:L:S35	R:R:H121	6.97	Yes	No	6	0	4
61	L:L:S35	R:R:N124	4.47	Yes	No	0	0	5
62	L:L:S35	R:R:W128	4.94	Yes	No	6	0	5
63	L:L:P38	L:L:T37	5.25	No	No	0	0	0
64	L:L:T37	R:R:W79	7.28	No	Yes	0	0	6
65	L:L:P38	R:R:D77	4.83	No	Yes	0	0	9
66	L:L:?102	R:R:H296	6.15	No	No	1	0	2
67	R:R:K46	R:R:V42	3.04	No	No	0	4	1
68	R:R:K47	R:R:V43	6.07	Yes	No	0	4	2
69	R:R:G44	R:R:K47	3.49	No	Yes	0	4	4
70	R:R:M49	R:R:R45	6.2	No	No	0	4	7
71	R:R:K46	R:R:K47	2.87	No	Yes	0	4	4
72	R:R:M48	R:R:Y98	8.38	No	Yes	0	6	4
73	R:R:M49	R:R:Y53	8.38	No	No	0	4	1
74	R:R:Q52	R:R:Y53	9.02	No	No	0	6	1
75	R:R:Q52	R:R:W76	4.38	No	Yes	0	6	8
76	R:R:C55	R:R:W76	3.92	No	Yes	7	9	8
77	R:R:C55	R:R:C81	7.28	No	No	7	9	9
78	R:R:D57	R:R:R58	8.34	No	No	0	4	3
79	R:R:C112	R:R:C72	7.28	No	No	4	9	9
80	R:R:K110	R:R:T75	3	Yes	No	0	8	5
81	R:R:G78	R:R:W76	8.44	No	Yes	0	5	8
82	R:R:C81	R:R:W76	9.14	No	Yes	7	9	8
83	R:R:D77	R:R:K110	4.15	Yes	Yes	2	9	8
84	R:R:D77	R:R:S129	4.42	Yes	Yes	2	9	7
85	R:R:D77	R:R:Y131	4.6	Yes	Yes	2	9	5
86	R:R:W79	R:R:Y98	2.89	Yes	Yes	2	6	4
87	R:R:F99	R:R:W79	12.03	Yes	Yes	2	5	6
88	R:R:F102	R:R:W79	5.01	Yes	Yes	2	4	6
89	R:R:W79	R:R:Y131	4.82	Yes	Yes	2	6	5
90	R:R:L80	R:R:P96	11.49	No	Yes	0	5	9
91	R:R:L80	R:R:Y131	5.86	No	Yes	0	5	5
92	R:R:D83	R:R:W82	3.35	No	No	0	5	9
93	R:R:T85	R:R:W82	7.28	Yes	No	4	7	9
94	R:R:S91	R:R:W82	14.83	No	No	4	5	9
95	R:R:P86	R:R:T85	3.5	Yes	Yes	0	2	7
96	R:R:S91	R:R:T85	3.2	No	Yes	4	5	7
97	R:R:C112	R:R:T85	3.38	No	Yes	4	9	7
98	R:R:P86	R:R:V89	3.53	Yes	No	0	2	5
99	R:R:G88	R:R:Y111	4.35	No	No	0	8	4
100	R:R:L90	R:R:Y111	9.38	No	No	0	4	4
101	R:R:K107	R:R:Y92	11.94	No	No	0	3	4
102	R:R:T109	R:R:Y92	11.24	No	No	0	5	4
103	R:R:F94	R:R:Q93	3.51	No	No	0	3	6
104	R:R:F94	R:R:K107	9.93	No	No	0	3	3
105	R:R:C95	R:R:P96	3.77	Yes	Yes	2	9	9
106	R:R:C95	R:R:F102	5.59	Yes	Yes	2	9	4
107	R:R:C95	R:R:V108	3.42	Yes	No	0	9	7
108	R:R:C134	R:R:C95	7.28	No	Yes	0	9	9
109	R:R:P96	R:R:Y98	12.52	Yes	Yes	2	9	4
110	R:R:F102	R:R:P96	5.78	Yes	Yes	2	4	9
111	R:R:D97	R:R:P104	6.44	No	No	0	2	3
112	R:R:F99	R:R:Y98	6.19	Yes	Yes	2	5	4
113	R:R:F102	R:R:F99	18.22	Yes	Yes	2	4	5
114	R:R:D101	R:R:N135	6.73	No	Yes	0	4	3
115	R:R:D101	R:R:T138	5.78	No	No	0	4	2
116	R:R:F102	R:R:N135	8.46	Yes	Yes	2	4	3
117	R:R:D103	R:R:P104	4.83	Yes	No	0	3	3
118	R:R:D103	R:R:S105	8.83	Yes	No	0	3	1
119	R:R:E106	R:R:M133	5.41	No	No	0	4	5
120	R:R:E106	R:R:F137	10.49	No	No	0	4	1
121	R:R:V108	R:R:Y131	13.88	No	Yes	0	7	5
122	R:R:N130	R:R:T109	4.39	No	No	0	8	5
123	R:R:K110	R:R:W118	31.33	Yes	Yes	2	8	9
124	R:R:K110	R:R:S129	7.65	Yes	Yes	2	8	7
125	R:R:D113	R:R:Y111	4.6	No	No	0	5	4
126	R:R:D113	R:R:F119	15.52	No	No	0	5	4
127	R:R:K120	R:R:V117	3.04	No	No	0	1	5
128	R:R:T127	R:R:W118	10.92	No	Yes	0	4	9
129	R:R:S129	R:R:W118	7.41	Yes	Yes	2	7	9
130	R:R:H121	R:R:P122	4.58	No	No	0	4	5
131	R:R:H121	R:R:W128	20.1	No	No	6	4	5
132	R:R:S129	R:R:Y131	3.82	Yes	Yes	2	7	5
133	R:R:N130	R:R:T132	4.39	No	No	0	8	6
134	R:R:C134	R:R:N135	3.15	No	Yes	0	9	3
135	R:R:P139	R:R:T138	5.25	No	No	0	3	2
136	R:R:E140	R:R:K370	5.4	No	No	0	2	4
137	R:R:K143	R:R:N144	4.2	No	No	0	1	4
138	R:R:K370	R:R:N144	6.99	No	No	0	4	4
139	R:R:N144	R:R:Y374	3.49	No	No	0	4	6
140	R:R:V147	R:R:Y374	6.31	No	No	0	4	6
141	R:R:L148	R:R:Y374	8.21	No	No	0	5	6
142	R:R:H377	R:R:L148	14.14	Yes	No	0	7	5
143	R:R:Y149	R:R:Y150	4.96	Yes	No	0	5	4
144	R:R:I153	R:R:Y149	8.46	No	Yes	0	7	5
145	R:R:L202	R:R:Y149	9.38	No	Yes	0	7	5
146	R:R:L151	R:R:S378	3	No	No	0	5	5
147	R:R:F382	R:R:L151	3.65	No	No	0	7	5
148	R:R:A152	R:R:H381	7.32	No	Yes	0	7	9
149	R:R:G155	R:R:V154	3.68	No	No	0	8	6
150	R:R:F382	R:R:G155	9.03	No	No	0	7	8
151	R:R:H156	R:R:S195	8.37	Yes	No	0	7	7
152	R:R:H156	R:R:I198	11.93	Yes	No	0	7	7
153	R:R:H156	R:R:I199	3.98	Yes	No	0	7	7
154	R:R:H156	R:R:H381	9.55	Yes	Yes	0	7	9
155	R:R:I199	R:R:S157	3.1	No	No	0	7	7
156	R:R:L158	R:R:T162	2.95	No	No	8	4	6
157	R:R:F385	R:R:L158	14.61	Yes	No	8	5	4
158	R:R:L163	R:R:S159	4.5	Yes	No	0	8	9
159	R:R:S159	R:R:S195	4.89	No	No	0	9	7
160	R:R:I160	R:R:I192	2.94	No	Yes	0	5	7
161	R:R:I160	R:R:S195	4.64	No	No	0	5	7
162	R:R:I160	R:R:M196	4.37	No	No	0	5	4
163	R:R:F161	R:R:I165	6.28	No	No	0	4	5
164	R:R:F385	R:R:T162	6.49	Yes	No	8	5	6
165	R:R:F188	R:R:L163	4.87	Yes	Yes	0	8	8
166	R:R:L163	R:R:Y191	5.86	Yes	Yes	0	8	8
167	R:R:I192	R:R:L163	4.28	Yes	Yes	0	7	8
168	R:R:A388	R:R:L163	3.15	No	Yes	0	8	8
169	R:R:I165	R:R:I169	2.94	No	No	0	5	8
170	R:R:F393	R:R:I165	3.77	Yes	No	0	8	5
171	R:R:F188	R:R:S166	7.93	Yes	No	0	8	9
172	R:R:C392	R:R:S166	6.89	Yes	No	0	9	9
173	R:R:F188	R:R:L167	3.65	Yes	No	0	8	6
174	R:R:I192	R:R:L167	2.85	Yes	No	0	7	6
175	R:R:C392	R:R:I169	4.91	Yes	No	0	9	8
176	R:R:F170	R:R:V181	5.24	No	Yes	0	8	9
177	R:R:F170	R:R:F188	6.43	No	Yes	0	8	8
178	R:R:C392	R:R:F170	8.38	Yes	No	0	9	8
179	R:R:F173	R:R:T401	3.89	No	Yes	0	7	7
180	R:R:F173	R:R:Q405	4.68	No	No	0	7	4
181	R:R:L176	R:R:S175	3	No	No	9	9	8
182	R:R:S175	R:R:T401	3.2	No	Yes	9	8	7
183	R:R:L176	R:R:V398	5.96	No	No	0	9	9
184	R:R:L176	R:R:T401	5.9	No	Yes	9	9	7
185	R:R:G177	R:R:V181	5.52	No	Yes	0	7	9
186	R:R:C178	R:R:R180	5.57	No	Yes	0	8	9
187	R:R:C178	R:R:V181	3.42	No	Yes	0	8	9
188	R:R:Q179	R:R:Y243	4.51	Yes	Yes	3	7	8
189	R:R:Q179	R:R:Q257	7.68	Yes	No	3	7	5
190	R:R:L259	R:R:Q179	3.99	No	Yes	0	5	7
191	R:R:H184	R:R:R180	5.64	Yes	Yes	0	9	9
192	R:R:R180	R:R:Y243	3.09	Yes	Yes	3	9	8
193	R:R:N395	R:R:R180	3.62	No	Yes	3	9	9
194	R:R:E397	R:R:R180	4.65	No	Yes	3	9	9
195	R:R:K185	R:R:V181	4.55	No	Yes	0	6	9
196	R:R:L259	R:R:T182	2.95	No	No	0	5	5
197	R:R:T182	R:R:Y263	3.75	No	No	0	5	5
198	R:R:E240	R:R:L183	7.95	Yes	Yes	0	9	8
199	R:R:L183	R:R:Y243	3.52	Yes	Yes	3	8	8
200	R:R:L183	R:R:L259	4.15	Yes	No	0	8	5
201	R:R:L183	R:R:Y262	4.69	Yes	No	3	8	7
202	R:R:F188	R:R:H184	3.39	Yes	Yes	0	8	9
203	R:R:E240	R:R:H184	8.62	Yes	Yes	0	9	9
204	R:R:H184	R:R:Y391	8.71	Yes	No	0	9	8
205	R:R:N186	R:R:W236	14.69	No	Yes	1	9	9
206	R:R:N186	R:R:Y263	12.79	No	No	1	9	5
207	R:R:N186	R:R:W267	4.52	No	Yes	1	9	9
208	R:R:M187	R:R:Y191	8.38	No	Yes	0	8	8
209	R:R:E240	R:R:M187	4.06	Yes	No	0	9	8
210	R:R:N233	R:R:T190	4.39	No	No	1	9	9
211	R:R:T190	R:R:W236	3.64	No	Yes	1	9	9
212	R:R:T190	R:R:W267	6.06	No	Yes	1	9	9
213	R:R:N233	R:R:Y191	11.63	No	Yes	1	9	8
214	R:R:M237	R:R:Y191	4.79	Yes	Yes	1	9	8
215	R:R:Q383	R:R:Y191	4.51	No	Yes	1	9	8
216	R:R:G384	R:R:Y191	5.79	No	Yes	0	9	8
217	R:R:V387	R:R:Y191	5.05	No	Yes	0	9	8
218	R:R:L193	R:R:M229	7.07	No	No	0	6	4
219	R:R:I198	R:R:N194	5.66	No	No	0	7	8
220	R:R:H226	R:R:I197	3.98	Yes	No	0	6	5
221	R:R:I197	R:R:M229	2.92	No	No	0	5	4
222	R:R:H226	R:R:I198	3.98	Yes	No	0	6	7
223	R:R:H201	R:R:V206	4.15	Yes	No	0	6	3
224	R:R:H201	R:R:H223	3.58	Yes	No	0	6	5
225	R:R:P207	R:R:V206	5.3	No	No	0	3	3
226	R:R:G209	R:R:R213	3	No	No	0	3	2
227	R:R:E210	R:R:R214	4.65	No	No	0	3	4
228	R:R:L211	R:R:P216	6.57	No	Yes	10	1	4
229	R:R:C219	R:R:L211	6.35	No	No	10	9	1
230	R:R:N288	R:R:V212	4.43	No	No	0	4	3
231	R:R:D215	R:R:N288	10.77	No	No	0	6	4
232	R:R:P216	R:R:S218	3.56	Yes	No	0	4	3
233	R:R:C219	R:R:P216	3.77	No	Yes	10	9	4
234	R:R:C219	R:R:C289	7.28	No	No	0	9	9
235	R:R:K220	R:R:N286	4.2	No	No	0	7	7
236	R:R:K220	R:R:W290	12.76	No	No	0	7	9
237	R:R:F224	R:R:I221	3.77	No	No	0	5	4
238	R:R:H223	R:R:Q227	9.89	No	Yes	0	5	7
239	R:R:H223	R:R:L291	7.71	No	No	0	5	6
240	R:R:F224	R:R:T274	6.49	No	No	0	5	6
241	R:R:H226	R:R:M230	3.94	Yes	No	1	6	6
242	R:R:H277	R:R:Q227	4.95	Yes	Yes	1	7	7
243	R:R:I301	R:R:Q227	5.49	No	Yes	1	7	7
244	R:R:C232	R:R:Y228	8.06	No	No	0	8	8
245	R:R:L271	R:R:Y228	4.69	No	No	11	4	8
246	R:R:T274	R:R:Y228	3.75	No	No	11	6	8
247	R:R:M230	R:R:Y234	4.79	No	Yes	1	6	7
248	R:R:C232	R:R:P270	9.41	No	Yes	0	8	9
249	R:R:M237	R:R:N233	4.21	Yes	No	1	9	9
250	R:R:M237	R:R:Y234	5.99	Yes	Yes	1	9	7
251	R:R:V305	R:R:Y234	11.36	No	Yes	1	7	7
252	R:R:F356	R:R:Y234	11.35	Yes	Yes	1	7	7
253	R:R:F235	R:R:F269	9.65	Yes	No	12	5	3
254	R:R:F235	R:R:P270	5.78	Yes	Yes	12	5	9
255	R:R:F235	R:R:P304	2.89	Yes	No	0	5	9
256	R:R:G266	R:R:W236	8.44	No	Yes	0	9	9
257	R:R:W236	R:R:W267	14.06	Yes	Yes	1	9	9
258	R:R:M237	R:R:Q383	4.08	Yes	No	1	9	9
259	R:R:I242	R:R:L238	7.14	No	No	0	7	8
260	R:R:A308	R:R:L238	6.3	No	No	0	7	8
261	R:R:L238	R:R:V311	2.98	No	No	0	8	6
262	R:R:C239	R:R:L265	4.76	No	No	0	7	7
263	R:R:E240	R:R:L351	7.95	Yes	No	0	9	9
264	R:R:G241	R:R:N312	5.09	No	No	0	8	9
265	R:R:I242	R:R:Y262	4.84	No	No	0	7	7
266	R:R:F315	R:R:I242	6.28	No	No	0	8	7
267	R:R:L247	R:R:Y243	9.38	No	Yes	0	8	8
268	R:R:Q257	R:R:Y243	6.76	No	Yes	3	5	8
269	R:R:Y243	R:R:Y262	7.94	Yes	No	3	8	7
270	R:R:I319	R:R:L244	4.28	No	No	0	9	9
271	R:R:L244	R:R:L348	4.15	No	No	0	9	9
272	R:R:H245	R:R:V249	16.61	Yes	Yes	5	8	6
273	R:R:H245	R:R:V250	4.15	Yes	No	5	8	5
274	R:R:F315	R:R:H245	22.63	No	Yes	0	8	8
275	R:R:H245	R:R:N318	10.2	Yes	No	5	8	8
276	R:R:T246	R:R:V250	3.17	No	No	0	7	5
277	R:R:Q257	R:R:T246	5.67	No	No	0	5	7
278	R:R:I248	R:R:I319	2.94	No	No	0	7	9
279	R:R:V249	R:R:V250	3.21	Yes	No	5	6	5
280	R:R:N318	R:R:V249	7.39	No	Yes	5	8	6
281	R:R:V249	R:R:V322	3.21	Yes	No	0	6	8
282	R:R:W267	R:R:Y263	2.89	Yes	No	1	9	5
283	R:R:F269	R:R:L265	4.87	No	No	0	3	7
284	R:R:F269	R:R:P270	4.33	No	Yes	12	3	9
285	R:R:L271	R:R:T274	4.42	No	No	11	4	6
286	R:R:L271	R:R:T275	2.95	No	No	0	4	3
287	R:R:P273	R:R:V272	3.53	No	No	0	6	4
288	R:R:I276	R:R:V272	3.07	No	No	0	5	4
289	R:R:I276	R:R:I300	2.94	No	No	0	5	8
290	R:R:H277	R:R:R281	16.93	Yes	Yes	1	7	7
291	R:R:H277	R:R:L298	3.86	Yes	No	1	7	6
292	R:R:H277	R:R:I300	3.98	Yes	No	0	7	8
293	R:R:H277	R:R:I301	13.26	Yes	No	1	7	7
294	R:R:T280	R:R:Y284	4.99	No	No	0	4	2
295	R:R:L297	R:R:T280	7.37	No	No	0	4	4
296	R:R:F285	R:R:R281	3.21	Yes	Yes	1	6	7
297	R:R:R281	R:R:W290	11	Yes	No	0	7	9
298	R:R:R281	R:R:T295	5.17	Yes	No	1	7	4
299	R:R:L297	R:R:R281	4.86	No	Yes	1	4	7
300	R:R:V283	R:R:Y284	5.05	No	No	0	3	2
301	R:R:D287	R:R:F285	15.52	No	Yes	1	3	6
302	R:R:F285	R:R:S292	5.28	Yes	No	1	6	4
303	R:R:F285	R:R:T295	15.56	Yes	No	1	6	4
304	R:R:D287	R:R:S292	10.31	No	No	1	3	4
305	R:R:C289	R:R:L291	4.76	No	No	0	9	6
306	R:R:L298	R:R:V293	2.98	No	No	1	6	6
307	R:R:L297	R:R:T295	5.9	No	No	1	4	4
308	R:R:G303	R:R:P304	4.06	No	No	0	4	9
309	R:R:L309	R:R:V305	2.98	No	No	0	7	7
310	R:R:F356	R:R:L309	4.87	Yes	No	0	7	7
311	R:R:F314	R:R:V310	3.93	No	No	0	5	4
312	R:R:V310	R:R:V357	3.21	No	No	0	4	7
313	R:R:F315	R:R:V311	5.24	No	No	0	8	6
314	R:R:L352	R:R:N312	6.87	No	No	0	9	9
315	R:R:F313	R:R:L317	8.53	No	No	0	6	5
316	R:R:F313	R:R:I354	5.02	No	Yes	0	6	6
317	R:R:F313	R:R:V357	3.93	No	No	0	6	7
318	R:R:L316	R:R:V320	2.98	No	No	0	9	7
319	R:R:L316	R:R:L348	4.15	No	No	0	9	9
320	R:R:I354	R:R:L316	7.14	Yes	No	0	6	9
321	R:R:N318	R:R:R321	3.62	No	No	0	8	8
322	R:R:T345	R:R:V320	3.17	No	No	0	9	7
323	R:R:R328	R:R:V324	3.92	No	No	0	6	5
324	R:R:M327	R:R:M337	2.89	Yes	No	0	7	7
325	R:R:K340	R:R:M327	5.76	No	Yes	0	8	7
326	R:R:M337	R:R:R328	6.2	No	No	0	7	6
327	R:R:E334	R:R:Y338	8.98	No	No	0	6	7
328	R:R:I347	R:R:K343	4.36	No	No	0	8	8
329	R:R:I347	R:R:I390	2.94	No	No	0	8	8
330	R:R:P350	R:R:V349	5.3	No	No	0	9	8
331	R:R:I354	R:R:V349	7.68	Yes	No	0	6	8
332	R:R:L351	R:R:L352	4.15	No	No	0	9	9
333	R:R:L351	R:R:Y391	15.24	No	No	0	9	8
334	R:R:I354	R:R:L352	2.85	Yes	No	0	6	9
335	R:R:G353	R:R:Q355	3.29	No	No	1	9	8
336	R:R:F356	R:R:G353	3.01	Yes	No	1	7	9
337	R:R:F356	R:R:Q355	4.68	Yes	No	1	7	8
338	R:R:Q355	R:R:Q383	14.08	No	No	1	8	9
339	R:R:F356	R:R:I380	10.05	Yes	No	0	7	6
340	R:R:F359	R:R:V358	6.55	No	No	0	6	5
341	R:R:F359	R:R:Y372	4.13	No	Yes	0	6	7
342	R:R:P360	R:R:W361	4.05	No	No	0	5	4
343	R:R:R362	R:R:Y372	4.12	No	Yes	0	4	7
344	R:R:D373	R:R:R362	11.91	No	No	0	5	4
345	R:R:L368	R:R:P363	8.21	No	No	0	3	7
346	R:R:P363	R:R:Y372	5.56	No	Yes	0	7	7
347	R:R:L368	R:R:N365	6.87	No	No	0	3	4
348	R:R:I371	R:R:M367	2.92	No	No	0	5	4
349	R:R:M376	R:R:Y372	3.59	No	Yes	0	7	7
350	R:R:L379	R:R:V375	2.98	No	No	0	5	4
351	R:R:I380	R:R:M376	5.83	No	No	0	6	7
352	R:R:H377	R:R:H381	8.36	Yes	Yes	0	7	9
353	R:R:H381	R:R:I380	3.98	Yes	No	0	9	6
354	R:R:F382	R:R:F386	4.29	No	No	0	7	5
355	R:R:F385	R:R:F386	5.36	Yes	No	0	5	5
356	R:R:F385	R:R:T389	7.78	Yes	No	0	5	5
357	R:R:I390	R:R:Y391	7.25	No	No	0	8	8
358	R:R:C392	R:R:F393	4.19	Yes	Yes	0	9	8
359	R:R:E397	R:R:N395	6.57	No	No	3	9	9
360	R:R:N395	R:R:V398	7.39	No	No	0	9	9
361	R:R:N396	R:R:T400	2.92	No	No	0	6	4
362	R:R:K403	R:R:Q399	6.78	No	No	0	6	7
363	R:R:Q408	R:R:R404	4.67	No	No	0	7	7
364	R:R:K410	R:R:W406	17.4	No	No	0	4	6
365	R:R:F409	R:R:Q412	8.2	No	No	13	3	4
366	R:R:F409	R:R:W413	3.01	No	No	13	3	3
367	R:R:Q412	R:R:W413	3.29	No	No	13	4	3
368	R:R:L323	R:R:M327	2.83	No	Yes	0	9	7
369	R:R:K120	R:R:N125	2.8	No	No	0	1	7
370	R:R:P86	R:R:Y71	2.78	Yes	No	0	2	3
371	L:L:F16	R:R:A145	2.77	Yes	No	0	0	4
372	R:R:D50	R:R:K54	2.77	No	No	0	2	4
373	R:R:A136	R:R:F137	2.77	No	No	0	2	1
374	R:R:L189	R:R:L193	2.77	No	No	0	3	6
375	R:R:H201	R:R:V205	2.77	Yes	No	0	6	7
376	R:R:A278	R:R:F224	2.77	No	No	0	6	5
377	R:R:A308	R:R:F235	2.77	No	Yes	0	7	5
378	R:R:K256	R:R:Q179	2.71	No	Yes	0	5	7
379	R:R:A51	R:R:Y98	2.67	No	Yes	0	8	4
380	R:R:E123	R:R:N124	2.63	No	No	0	4	5
381	R:R:F173	R:R:V402	2.62	No	No	0	7	5
382	R:R:F253	R:R:V252	2.62	No	No	0	6	7
383	R:R:F359	R:R:V375	2.62	No	No	0	6	4
384	R:R:F393	R:R:T162	2.59	Yes	No	0	8	6
385	R:R:R321	R:R:T325	2.59	No	No	0	8	7
386	R:R:F393	R:R:T389	2.59	Yes	No	0	8	5
387	R:R:K47	R:R:Y98	2.39	Yes	Yes	0	4	4
388	R:R:H296	R:R:Y299	2.18	No	No	0	2	7
389	R:R:G268	R:R:P270	2.03	No	Yes	0	6	9
390	R:R:G369	R:R:P363	2.03	No	No	0	4	7
391	R:R:C72	R:R:G116	1.96	No	Yes	4	9	9
392	R:R:C112	R:R:G116	1.96	No	Yes	4	9	9
393	L:L:P29	L:L:P30	1.95	No	No	0	0	0
394	R:R:A87	R:R:G116	1.95	No	Yes	0	4	9
395	R:R:A231	R:R:P270	1.87	No	Yes	0	5	9
396	R:R:G88	R:R:V89	1.84	No	No	0	8	5
397	R:R:G116	R:R:V117	1.84	Yes	No	0	9	5
398	L:L:N23	R:R:G209	1.7	No	No	0	0	3
399	R:R:A341	R:R:V324	1.7	No	No	0	9	5
400	R:R:D77	R:R:G78	1.68	Yes	No	0	9	5
401	R:R:A136	R:R:T132	1.68	No	No	0	2	6
402	R:R:A251	R:R:T246	1.68	No	No	0	6	7
403	L:L:L28	L:L:P29	1.64	No	No	0	0	0
404	R:R:D84	R:R:P86	1.61	No	Yes	0	4	2
405	L:L:L13	R:R:A145	1.58	No	No	0	0	4
406	L:L:L17	R:R:A145	1.58	No	No	0	0	4
407	R:R:A344	R:R:L323	1.58	No	No	0	9	9
408	R:R:T400	R:R:T401	1.57	No	Yes	0	4	7
409	R:R:I153	R:R:V203	1.54	No	No	0	7	3
410	R:R:I192	R:R:V164	1.54	Yes	No	0	7	4
411	R:R:I199	R:R:V203	1.54	No	No	0	7	3
412	R:R:I279	R:R:V283	1.54	No	No	0	3	3
413	R:R:I371	R:R:V375	1.54	No	No	0	5	4
414	R:R:K185	R:R:V171	1.52	No	No	0	6	4
415	R:R:K403	R:R:V402	1.52	No	No	0	6	5
416	L:L:T7	R:R:M306	1.51	Yes	No	0	0	4
417	R:R:L222	R:R:V205	1.49	No	No	0	6	7
418	R:R:A333	R:R:H336	1.46	No	No	0	5	6
419	R:R:D103	R:R:T138	1.45	Yes	No	0	3	2
420	R:R:F99	R:R:P100	1.44	Yes	No	0	5	4
421	R:R:P216	R:R:R214	1.44	Yes	No	0	4	4
422	R:R:K366	R:R:K370	1.44	No	No	0	3	4
423	R:R:E329	R:R:T325	1.41	No	No	0	6	7
424	R:R:H336	R:R:S335	1.39	No	No	0	6	6
425	R:R:E204	R:R:I200	1.37	No	No	0	4	6
426	R:R:L211	R:R:N208	1.37	No	No	0	1	3
427	R:R:E114	R:R:K115	1.35	No	No	0	2	5
428	R:R:E329	R:R:K326	1.35	No	No	0	6	9
429	R:R:E332	R:R:M327	1.35	No	Yes	0	5	7
430	R:R:E334	R:R:M337	1.35	No	No	0	6	7
431	R:R:F172	R:R:V171	1.31	No	No	0	2	4
432	R:R:E204	R:R:N208	1.31	No	No	0	4	3
433	R:R:A282	R:R:W290	1.3	No	No	0	3	9
434	R:R:R404	R:R:T400	1.29	No	No	0	7	4
435	R:R:F225	R:R:I221	1.26	No	No	0	5	4
436	R:R:K256	R:R:R260	1.24	No	No	0	5	3
437	R:R:V117	R:R:W118	1.23	No	Yes	0	5	9
438	R:R:E332	R:R:H336	1.23	No	No	0	5	6
439	R:R:E255	R:R:F253	1.17	No	No	0	6	6
440	R:R:F409	R:R:Q405	1.17	No	No	0	3	4
441	R:R:R213	R:R:R214	1.07	No	No	0	2	4
442	R:R:R260	R:R:W261	1	No	No	0	3	2

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:K2	8.315	4	1	0
2	L:L:C3	4.295	6	1	0
3	L:L:T7	5.23333	6	1	0
4	L:L:C8	6.6025	4	1	0
5	L:L:Q11	5.7425	4	1	0
6	L:L:E15	5.545	4	1	0
7	L:L:F16	4.1475	4	0	0
8	L:L:F24	5.0875	4	0	0
9	L:L:S35	4.84	4	6	0
10	R:R:K47	3.705	4	0	4
11	R:R:W76	6.47	4	7	8
12	R:R:D77	3.936	5	2	9
13	R:R:W79	6.406	5	2	6
14	R:R:T85	4.34	4	4	7
15	R:R:P86	2.855	4	0	2
16	R:R:C95	5.015	4	2	9
17	R:R:P96	8.39	4	2	9
18	R:R:Y98	5.84	6	2	4
19	R:R:F99	8.874	5	2	5
20	R:R:F102	8.25833	6	2	4
21	R:R:D103	4.6725	4	0	3
22	R:R:K110	11.5325	4	2	8
23	R:R:G116	1.9275	4	4	9
24	R:R:W118	12.7225	4	2	9
25	R:R:S129	5.825	4	2	7
26	R:R:Y131	6.596	5	2	5
27	R:R:N135	5.73	5	2	3
28	R:R:Y149	6.764	5	0	5
29	R:R:H156	8.4575	4	0	7
30	R:R:L163	4.532	5	0	8
31	R:R:Q179	4.7225	4	3	7
32	R:R:R180	4.514	5	3	9
33	R:R:V181	4.6825	4	0	9
34	R:R:L183	5.0775	4	3	8
35	R:R:H184	6.59	4	0	9
36	R:R:F188	5.254	5	0	8
37	R:R:Y191	6.57286	7	1	8
38	R:R:I192	2.9025	4	0	7
39	R:R:H201	3.3575	4	0	6
40	R:R:P216	3.835	4	10	4
41	R:R:H226	4.2125	4	1	6
42	R:R:Q227	6.3625	4	1	7
43	R:R:Y234	8.446	5	1	7
44	R:R:F235	5.2725	4	12	5
45	R:R:W236	10.2075	4	1	9
46	R:R:M237	4.7675	4	1	9
47	R:R:E240	7.145	4	0	9
48	R:R:Y243	5.86667	6	3	8
49	R:R:H245	13.3975	4	5	8
50	R:R:V249	7.605	4	5	6
51	R:R:W267	6.8825	4	1	9
52	R:R:P270	4.684	5	12	9
53	R:R:H277	8.596	5	1	7
54	R:R:R281	8.234	5	1	7
55	R:R:F285	9.8925	4	1	6
56	R:R:M327	3.2075	4	0	7
57	R:R:I354	5.6725	4	0	6
58	R:R:F356	6.2	7	1	7
59	R:R:Y372	4.35	4	0	7
60	R:R:H377	7.6425	4	0	7
61	R:R:H381	7.212	5	0	9
62	R:R:F385	8.56	4	8	5
63	R:R:C392	6.0925	4	0	9
64	R:R:F393	3.285	4	0	8
65	R:R:T401	3.64	4	9	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:E15	R:R:V293	12.7367	5.7	Yes	No	1	0	6
2	L:L:C3	R:R:V293	13.4665	3.42	Yes	No	1	0	6
3	L:L:T7	R:R:H302	10.8598	10.95	Yes	No	1	0	6
4	L:L:T7	R:R:F356	11.0825	3.89	Yes	Yes	1	0	7
5	L:L:A6	R:R:F356	11.364	5.55	No	Yes	0	0	7
6	L:L:A6	R:R:M376	10.6244	3.22	No	No	0	0	7
7	R:R:F356	R:R:I380	45.0947	10.05	Yes	No	0	7	6
8	R:R:I380	R:R:M376	15.7034	5.83	No	No	0	6	7
9	L:L:T7	R:R:Y234	10.4522	8.74	Yes	Yes	1	0	7
10	R:R:H381	R:R:I380	39.6515	3.98	Yes	No	0	9	6
11	R:R:H377	R:R:H381	97.3274	8.36	Yes	Yes	0	7	9
12	R:R:H277	R:R:Q227	15.1852	4.95	Yes	Yes	1	7	7
13	L:L:Q11	R:R:M230	16.3926	6.8	Yes	No	1	0	6
14	L:L:L13	R:R:H377	91.9767	5.14	No	Yes	0	0	7
15	R:R:H223	R:R:L291	11.745	7.71	No	No	0	5	6
16	R:R:H201	R:R:H223	10.6693	3.58	Yes	No	0	6	5
17	L:L:L13	R:R:A145	91.4612	1.58	No	No	0	0	4
18	L:L:F16	R:R:A145	100	2.77	Yes	No	0	0	4
19	L:L:F16	R:R:D103	97.5067	3.58	Yes	Yes	0	0	3
20	L:L:F24	R:R:Y149	11.2674	5.16	Yes	Yes	0	0	5
21	L:L:L17	R:R:Y149	11.1539	5.86	No	Yes	0	0	5
22	R:R:D103	R:R:T138	94.9686	1.45	Yes	No	0	3	2
23	R:R:D101	R:R:T138	93.6828	5.78	No	No	0	4	2
24	R:R:D101	R:R:N135	89.094	6.73	No	Yes	0	4	3
25	R:R:F102	R:R:N135	68.5273	8.46	Yes	Yes	2	4	3
26	R:R:F102	R:R:W79	49.5069	5.01	Yes	Yes	2	4	6
27	L:L:T37	R:R:W79	11.6175	7.28	No	Yes	0	0	6
28	L:L:N32	L:L:T37	10.7645	4.39	No	No	0	0	0
29	L:L:V33	R:R:N135	11.4285	7.39	No	Yes	0	0	3
30	L:L:V33	R:R:T132	10.5068	4.76	No	No	0	0	6
31	R:R:W79	R:R:Y131	32.0848	4.82	Yes	Yes	2	6	5
32	R:R:F99	R:R:Y98	13.4287	6.19	Yes	Yes	2	5	4
33	R:R:K47	R:R:Y98	17.1854	2.39	Yes	Yes	0	4	4
34	R:R:S129	R:R:Y131	21.9885	3.82	Yes	Yes	2	7	5
35	R:R:S129	R:R:W118	20.0905	7.41	Yes	Yes	2	7	9
36	R:R:V117	R:R:W118	18.9923	1.23	No	Yes	0	5	9
37	R:R:G116	R:R:V117	16.2147	1.84	Yes	No	0	9	5
38	R:R:C112	R:R:G116	13.3923	1.96	No	Yes	4	9	9
39	R:R:C112	R:R:T85	12.472	3.38	No	Yes	4	9	7
40	R:R:M237	R:R:Y234	49.1035	5.99	Yes	Yes	1	9	7
41	R:R:M237	R:R:Y191	45.3874	4.79	Yes	Yes	1	9	8
42	R:R:L163	R:R:Y191	34.2069	5.86	Yes	Yes	0	8	8
43	R:R:F188	R:R:L163	70.0233	4.87	Yes	Yes	0	8	8
44	R:R:F188	R:R:S166	18.1141	7.93	Yes	No	0	8	9
45	R:R:C392	R:R:S166	17.4221	6.89	Yes	No	0	9	9
46	R:R:C392	R:R:F393	31.285	4.19	Yes	Yes	0	9	8
47	R:R:F393	R:R:T162	14.1276	2.59	Yes	No	0	8	6
48	R:R:F385	R:R:T162	11.0012	6.49	Yes	No	8	5	6
49	R:R:F385	R:R:F386	18.8747	5.36	Yes	No	0	5	5
50	R:R:F382	R:R:F386	15.7357	4.29	No	No	0	7	5
51	R:R:F170	R:R:F188	21.4618	6.43	No	Yes	0	8	8
52	R:R:C392	R:R:F170	20.0751	8.38	Yes	No	0	9	8
53	R:R:F393	R:R:T389	12.5616	2.59	Yes	No	0	8	5
54	R:R:F385	R:R:T389	11.0026	7.78	Yes	No	0	5	5
55	R:R:H156	R:R:S195	63.325	8.37	Yes	No	0	7	7
56	R:R:L163	R:R:S159	61.8221	4.5	Yes	No	0	8	9
57	R:R:S159	R:R:S195	61.7128	4.89	No	No	0	9	7
58	R:R:F188	R:R:H184	53.6208	3.39	Yes	Yes	0	8	9
59	R:R:H184	R:R:R180	34.6748	5.64	Yes	Yes	0	9	9
60	R:R:N395	R:R:R180	17.2989	3.62	No	Yes	3	9	9
61	R:R:N395	R:R:V398	16.3366	7.39	No	No	0	9	9
62	R:R:L176	R:R:V398	15.3365	5.96	No	No	0	9	9
63	R:R:L176	R:R:T401	13.3096	5.9	No	Yes	9	9	7
64	R:R:M187	R:R:Y191	57.9	8.38	No	Yes	0	8	8
65	R:R:E240	R:R:M187	57.1759	4.06	Yes	No	0	9	8
66	R:R:E240	R:R:H184	23.6539	8.62	Yes	Yes	0	9	9
67	R:R:E240	R:R:L183	45.1689	7.95	Yes	Yes	0	9	8
68	R:R:L183	R:R:Y262	38.65	4.69	Yes	No	3	8	7
69	R:R:H184	R:R:Y391	10.5964	8.71	Yes	No	0	9	8
70	R:R:E240	R:R:L351	25.8614	7.95	Yes	No	0	9	9
71	R:R:F356	R:R:Q355	20.5709	4.68	Yes	No	1	7	8
72	R:R:Q355	R:R:Q383	20.7082	14.08	No	No	1	8	9
73	R:R:H277	R:R:R281	13.0197	16.93	Yes	Yes	1	7	7
74	R:R:I242	R:R:Y262	49.3333	4.84	No	No	0	7	7
75	R:R:I242	R:R:L238	34.5711	7.14	No	No	0	7	8
76	R:R:A308	R:R:L238	31.6688	6.3	No	No	0	7	8
77	R:R:A308	R:R:F235	30.0272	2.77	No	Yes	0	7	5
78	R:R:F235	R:R:P270	20.0681	5.78	Yes	Yes	12	5	9
79	R:R:C232	R:R:P270	15.1263	9.41	No	Yes	0	8	9
80	R:R:C232	R:R:Y228	13.4567	8.06	No	No	0	8	8
81	R:R:F315	R:R:I242	13.8517	6.28	No	No	0	8	7
82	R:R:L351	R:R:L352	29.8507	4.15	No	No	0	9	9
83	R:R:I354	R:R:L352	24.9384	2.85	Yes	No	0	6	9
84	R:R:I354	R:R:L316	11.7156	7.14	Yes	No	0	6	9
85	R:R:F315	R:R:H245	10.9102	22.63	No	Yes	0	8	8
86	R:R:H245	R:R:N318	10.469	10.2	Yes	No	5	8	8
87	R:R:N318	R:R:R321	10.0445	3.62	No	No	0	8	8
88	R:R:M376	R:R:Y372	24.0349	3.59	No	Yes	0	7	7
89	R:R:F359	R:R:Y372	11.1511	4.13	No	Yes	0	6	7
90	L:L:Q11	R:R:Q227	21.6635	5.12	Yes	Yes	1	0	7
91	R:R:H223	R:R:Q227	14.6053	9.89	No	Yes	0	5	7
92	L:L:L17	R:R:A145	11.4789	1.58	No	No	0	0	4
93	R:R:M230	R:R:Y234	18.7696	4.79	No	Yes	1	6	7
94	R:R:H156	R:R:H381	64.475	9.55	Yes	Yes	0	7	9
95	R:R:F356	R:R:Y234	25.472	11.35	Yes	Yes	1	7	7
96	R:R:Q383	R:R:Y191	20.6634	4.51	No	Yes	1	9	8
97	R:R:R180	R:R:Y243	21.3946	3.09	Yes	Yes	3	9	8
98	R:R:Y243	R:R:Y262	12.2647	7.94	Yes	No	3	8	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:H296	3.46	1	No	No	0	2	0	1
L:L:K2	R:R:E294	13.5	1	Yes	No	0	3	0	1
L:L:C3	R:R:V293	3.42	1	Yes	No	0	6	0	1
L:L:C3	R:R:L298	3.17	1	Yes	No	0	6	0	1
L:L:C3	R:R:H302	2.95	1	Yes	No	0	6	0	1
L:L:N4	R:R:W361	6.78	0	No	No	0	4	0	1
L:L:A6	R:R:F356	5.55	0	No	Yes	0	7	0	1
L:L:A6	R:R:M376	3.22	0	No	No	0	7	0	1
L:L:T7	R:R:Y234	8.74	1	Yes	Yes	0	7	0	1
L:L:T7	R:R:H302	10.95	1	Yes	No	0	6	0	1
L:L:T7	R:R:V305	3.17	1	Yes	No	0	7	0	1
L:L:T7	R:R:F356	3.89	1	Yes	Yes	0	7	0	1
L:L:C8	R:R:H302	8.85	1	Yes	No	0	6	0	1
L:L:A9	R:R:H377	2.93	0	No	Yes	0	7	0	1
L:L:T10	R:R:H381	6.85	0	No	Yes	0	9	0	1
L:L:Q11	R:R:H226	4.95	1	Yes	Yes	0	6	0	1
L:L:Q11	R:R:Q227	5.12	1	Yes	Yes	0	7	0	1
L:L:Q11	R:R:M230	6.8	1	Yes	No	0	6	0	1
L:L:L13	R:R:H377	5.14	0	No	Yes	0	7	0	1
L:L:A14	R:R:H201	2.93	0	No	Yes	0	6	0	1
L:L:E15	R:R:V293	5.7	1	Yes	No	0	6	0	1
L:L:E15	R:R:E294	3.81	1	Yes	No	0	3	0	1
L:L:F16	R:R:D103	3.58	0	Yes	Yes	0	3	0	1
L:L:F16	R:R:K141	4.96	0	Yes	No	0	3	0	1
L:L:L17	R:R:Y149	5.86	0	No	Yes	0	5	0	1
L:L:R18	R:R:V212	7.85	0	No	No	0	3	0	1
L:L:R18	R:R:L291	9.72	0	No	No	0	6	0	1
L:L:S20	R:R:L142	6.01	0	No	No	0	2	0	1
L:L:F24	R:R:Y146	4.13	0	Yes	No	0	2	0	1
L:L:F24	R:R:Y149	5.16	0	Yes	Yes	0	5	0	1
L:L:F24	R:R:P207	5.78	0	Yes	No	0	3	0	1
L:L:P30	R:R:D101	3.22	0	No	No	0	4	0	1
L:L:T31	R:R:F99	6.49	2	No	Yes	0	5	0	1
L:L:T31	R:R:F102	6.49	2	No	Yes	0	4	0	1
L:L:T31	R:R:N135	2.92	2	No	Yes	0	3	0	1
L:L:V33	R:R:T132	4.76	0	No	No	0	6	0	1
L:L:V33	R:R:N135	7.39	0	No	Yes	0	3	0	1
L:L:G34	R:R:W128	4.22	0	No	No	0	5	0	1
L:L:S35	R:R:H121	6.97	6	Yes	No	0	4	0	1
L:L:S35	R:R:N124	4.47	6	Yes	No	0	5	0	1
L:L:S35	R:R:W128	4.94	6	Yes	No	0	5	0	1
L:L:T37	R:R:W79	7.28	0	No	Yes	0	6	0	1
L:L:P38	R:R:D77	4.83	0	No	Yes	0	9	0	1
L:L:?102	R:R:H296	6.15	1	No	No	0	2	0	1
R:R:D77	R:R:K110	4.15	2	Yes	Yes	9	8	1	2
R:R:D77	R:R:S129	4.42	2	Yes	Yes	9	7	1	2
R:R:D77	R:R:Y131	4.6	2	Yes	Yes	9	5	1	2
R:R:W79	R:R:Y98	2.89	2	Yes	Yes	6	4	1	2
R:R:F99	R:R:W79	12.03	2	Yes	Yes	5	6	1	1
R:R:F102	R:R:W79	5.01	2	Yes	Yes	4	6	1	1
R:R:W79	R:R:Y131	4.82	2	Yes	Yes	6	5	1	2
R:R:C95	R:R:P96	3.77	2	Yes	Yes	9	9	2	2
R:R:C95	R:R:F102	5.59	2	Yes	Yes	9	4	2	1
R:R:C134	R:R:C95	7.28	0	No	Yes	9	9	2	2
R:R:P96	R:R:Y98	12.52	2	Yes	Yes	9	4	2	2
R:R:F102	R:R:P96	5.78	2	Yes	Yes	4	9	1	2
R:R:F99	R:R:Y98	6.19	2	Yes	Yes	5	4	1	2
R:R:F102	R:R:F99	18.22	2	Yes	Yes	4	5	1	1
R:R:D101	R:R:N135	6.73	0	No	Yes	4	3	1	1
R:R:D101	R:R:T138	5.78	0	No	No	4	2	1	2
R:R:F102	R:R:N135	8.46	2	Yes	Yes	4	3	1	1
R:R:D103	R:R:P104	4.83	0	Yes	No	3	3	1	2
R:R:D103	R:R:S105	8.83	0	Yes	No	3	1	1	2
R:R:K110	R:R:S129	7.65	2	Yes	Yes	8	7	2	2
R:R:H121	R:R:P122	4.58	6	No	No	4	5	1	2
R:R:H121	R:R:W128	20.1	6	No	No	4	5	1	1
R:R:S129	R:R:Y131	3.82	2	Yes	Yes	7	5	2	2
R:R:N130	R:R:T132	4.39	0	No	No	8	6	2	1
R:R:C134	R:R:N135	3.15	0	No	Yes	9	3	2	1
R:R:H377	R:R:L148	14.14	0	Yes	No	7	5	1	2
R:R:Y149	R:R:Y150	4.96	0	Yes	No	5	4	1	2
R:R:I153	R:R:Y149	8.46	0	No	Yes	7	5	2	1
R:R:L202	R:R:Y149	9.38	0	No	Yes	7	5	2	1
R:R:A152	R:R:H381	7.32	0	No	Yes	7	9	2	1
R:R:H156	R:R:I198	11.93	0	Yes	No	7	7	2	2
R:R:H156	R:R:H381	9.55	0	Yes	Yes	7	9	2	1
R:R:H226	R:R:I197	3.98	1	Yes	No	6	5	1	2
R:R:H226	R:R:I198	3.98	1	Yes	No	6	7	1	2
R:R:H201	R:R:V206	4.15	0	Yes	No	6	3	1	2
R:R:H201	R:R:H223	3.58	0	Yes	No	6	5	1	2
R:R:P207	R:R:V206	5.3	0	No	No	3	3	1	2
R:R:G209	R:R:R213	3	0	No	No	3	2	1	2
R:R:N288	R:R:V212	4.43	0	No	No	4	3	2	1
R:R:H223	R:R:Q227	9.89	0	No	Yes	5	7	2	1
R:R:H223	R:R:L291	7.71	0	No	No	5	6	2	1
R:R:H226	R:R:M230	3.94	1	Yes	No	6	6	1	1
R:R:H277	R:R:Q227	4.95	1	Yes	Yes	7	7	2	1
R:R:I301	R:R:Q227	5.49	1	No	Yes	7	7	2	1
R:R:M230	R:R:Y234	4.79	1	No	Yes	6	7	1	1
R:R:M237	R:R:Y234	5.99	1	Yes	Yes	9	7	2	1
R:R:V305	R:R:Y234	11.36	1	No	Yes	7	7	1	1
R:R:F356	R:R:Y234	11.35	1	Yes	Yes	7	7	1	1
R:R:H277	R:R:L298	3.86	1	Yes	No	7	6	2	1
R:R:H277	R:R:I301	13.26	1	Yes	No	7	7	2	2
R:R:C289	R:R:L291	4.76	0	No	No	9	6	2	1
R:R:L298	R:R:V293	2.98	1	No	No	6	6	1	1
R:R:L309	R:R:V305	2.98	0	No	No	7	7	2	1
R:R:F356	R:R:L309	4.87	1	Yes	No	7	7	1	2
R:R:G353	R:R:Q355	3.29	1	No	No	9	8	2	2
R:R:F356	R:R:G353	3.01	1	Yes	No	7	9	1	2
R:R:F356	R:R:Q355	4.68	1	Yes	No	7	8	1	2
R:R:F356	R:R:I380	10.05	1	Yes	No	7	6	1	2
R:R:P360	R:R:W361	4.05	0	No	No	5	4	2	1
R:R:M376	R:R:Y372	3.59	0	No	Yes	7	7	1	2
R:R:I380	R:R:M376	5.83	0	No	No	6	7	2	1
R:R:H377	R:R:H381	8.36	0	Yes	Yes	7	9	1	1
R:R:H381	R:R:I380	3.98	0	Yes	No	9	6	1	2
L:L:F16	R:R:A145	2.77	0	Yes	No	0	4	0	1
R:R:H201	R:R:V205	2.77	0	Yes	No	6	7	1	2
R:R:E123	R:R:N124	2.63	0	No	No	4	5	2	1
R:R:H296	R:R:Y299	2.18	1	No	No	2	7	1	2
L:L:N23	R:R:G209	1.7	0	No	No	0	3	0	1
R:R:D77	R:R:G78	1.68	2	Yes	No	9	5	1	2
R:R:A136	R:R:T132	1.68	0	No	No	2	6	2	1
L:L:L13	R:R:A145	1.58	0	No	No	0	4	0	1
L:L:L17	R:R:A145	1.58	0	No	No	0	4	0	1
L:L:T7	R:R:M306	1.51	1	Yes	No	0	4	0	1
R:R:D103	R:R:T138	1.45	0	Yes	No	3	2	1	2
R:R:F99	R:R:P100	1.44	2	Yes	No	5	4	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9BUC_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.85
Number of Linked Nodes	378
Number of Links	442
Number of Hubs	65
Number of Links mediated by Hubs	239
Number of Communities	13
Number of Nodes involved in Communities	94
Number of Links involved in Communities	126

Path Summary
Number Of Nodes in MetaPath	99
Number Of Links MetaPath	98
Number of Shortest Paths	157207
Length Of Smallest Path	3
Average Path Length	18.3157
Length of Longest Path	44
Minimum Path Strength	1.12
Average Path Strength	5.5944
Maximum Path Strength	21.125
Minimum Path Correlation	0.7
Average Path Correlation	0.958548
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.84615
Average % Of Corr. Nodes	54.7993
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	49.0416
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • positive regulation of cell communication • regulation of cellular process • positive regulation of signal transduction • response to stimulus • signaling • positive regulation of biological process • regulation of signal transduction • intracellular signal transduction • cell communication • positive regulation of response to stimulus • regulation of intracellular signal transduction • intracellular signaling cassette • regulation of calcium-mediated signaling • positive regulation of calcium-mediated signaling • signal transduction • positive regulation of cellular process • regulation of biological process • regulation of signaling • biological regulation • positive regulation of intracellular signal transduction • regulation of response to stimulus • calcium-mediated signaling • regulation of cell communication • cellular process • positive regulation of signaling • apoptotic process • cell death • programmed cell death • positive regulation of programmed cell death • regulation of apoptotic process • regulation of programmed cell death • positive regulation of apoptotic process • behavior • multicellular organismal process • eating behavior • feeding behavior • cell-cell signaling • amylin receptor 1 signaling pathway • amylin receptor signaling pathway • calcitonin family receptor signaling pathway • G protein-coupled receptor signaling pathway • regulation of cellular component organization • negative regulation of cellular component organization • protein-containing complex organization • negative regulation of biological process • regulation of cellular component biogenesis • negative regulation of protein-containing complex assembly • cellular component organization • cellular component biogenesis • regulation of protein-containing complex assembly • cellular component assembly • protein-containing complex assembly • negative regulation of cellular process • cellular component organization or biogenesis • myeloid leukocyte differentiation • regulation of leukocyte differentiation • cellular developmental process • regulation of developmental process • cell development • regulation of cell differentiation • regulation of cell development • regulation of osteoclast differentiation • multicellular organism development • cell differentiation • osteoclast differentiation • anatomical structure development • regulation of immune system process • regulation of multicellular organismal process • negative regulation of cell differentiation • negative regulation of hemopoiesis • developmental process • regulation of multicellular organismal development • negative regulation of leukocyte differentiation • hemopoiesis • regulation of myeloid cell differentiation • negative regulation of developmental process • regulation of myeloid leukocyte differentiation • negative regulation of myeloid cell differentiation • negative regulation of osteoclast differentiation • negative regulation of myeloid leukocyte differentiation • negative regulation of cell development • myeloid cell differentiation • negative regulation of immune system process • immune system process • regulation of hemopoiesis • negative regulation of multicellular organismal process • leukocyte differentiation • positive regulation of MAPK cascade • regulation of MAPK cascade • MAPK cascade • negative regulation of tissue remodeling • homeostatic process • negative regulation of bone remodeling • regulation of bone remodeling • tissue homeostasis • regulation of tissue remodeling • regulation of bone resorption • bone resorption • negative regulation of bone resorption • multicellular organismal-level homeostasis • tissue remodeling • bone remodeling • anatomical structure homeostasis • amylin receptor 2 signaling pathway • system process • sensory perception • nervous system process • sensory perception of pain • positive regulation of cAMP/PKA signal transduction • cAMP/PKA signal transduction • regulation of cAMP/PKA signal transduction • negative regulation of amyloid fibril formation • regulation of amyloid fibril formation • amyloid fibril formation • regulation of primary metabolic process • negative regulation of supramolecular fiber organization • protein metabolic process • negative regulation of protein metabolic process • negative regulation of macromolecule metabolic process • regulation of protein metabolic process • negative regulation of metabolic process • primary metabolic process • regulation of macromolecule metabolic process • regulation of supramolecular fiber organization • metabolic process • macromolecule metabolic process • supramolecular fiber organization • regulation of metabolic process • amylin receptor 3 signaling pathway • cellular anatomical structure • extracellular region • somatodendritic compartment • cell body • neuronal cell body • extracellular space • binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • sensory perception of chemical stimulus • sensory perception of smell • cellular response to nitrogen compound • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular response to hormone stimulus • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • adaptive thermogenesis • positive regulation of metabolic process • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • localization • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • regulation of protein transport • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • inflammatory response to antigenic stimulus • regulation of response to stress • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • organelle • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of taste • sensory organ development • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • cell population proliferation • small GTPase-mediated signal transduction • Ras protein signal transduction • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • amide binding • amyloid-beta binding • peptide binding • calcitonin family receptor activity • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • calcitonin receptor activity • amylin receptor activity • calcitonin gene-related peptide receptor activity • calcitonin binding • calcitonin family binding • peptide hormone binding • hormone binding • positive regulation of cytosolic calcium ion concentration • catabolic process • RNA metabolic process • macromolecule catabolic process • nucleobase-containing compound metabolic process • post-transcriptional regulation of gene expression • regulation of RNA metabolic process • regulation of mRNA catabolic process • regulation of nucleobase-containing compound metabolic process • RNA catabolic process • regulation of biosynthetic process • mRNA catabolic process • regulation of catabolic process • gene expression • mRNA metabolic process • macromolecule biosynthetic process • nucleic acid metabolic process • nucleobase-containing compound catabolic process • regulation of mRNA stability • regulation of gene expression • negative regulation of gene expression • biosynthetic process • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • regulation of RNA stability • nucleic acid catabolic process • regulation of macromolecule biosynthetic process • regulation of mRNA metabolic process • positive regulation of ERK1 and ERK2 cascade • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of macromolecule biosynthetic process • positive regulation of gene expression • positive regulation of biosynthetic process • positive regulation of macromolecule metabolic process • regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • phosphatidylinositol 3-kinase/protein kinase B signal transduction • response to corticosteroid • response to steroid hormone • response to glucocorticoid • response to amyloid-beta • cell surface receptor signaling pathway • calcitonin gene-related peptide receptor signaling pathway • ossification • regulation of ossification • negative regulation of ossification • amylin receptor complex • amylin receptor complex 3 • receptor complex • plasma membrane signaling receptor complex • G protein-coupled receptor complex • calcitonin family receptor complex • amylin receptor complex 2 • amylin receptor complex 1 • axon • acrosomal vesicle • intracellular vesicle • cytoplasmic vesicle • secretory granule • secretory vesicle
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	GGL
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	GGL
Name	Glutamic acid
Synonyms	Glutamic acid
Identifier
Formula	C5 H9 N O4
Molecular Weight	147.129
SMILES
PubChem	44272391
Formal Charge	0
Total Atoms	19
Total Chiral Atoms	1
Total Bonds	18
Total Aromatic Bonds	0


Code	A1B
PDB Residues	L:L:?102
Environment Details	Open EMBL-EBI Page
Code	A1B
Name	1-deoxy-alpha-L-xylulofuranose-1,2-borate
Synonyms
Identifier
Formula	C5 H10 B O6
Molecular Weight	176.94
SMILES
PubChem	118797262
Formal Charge	-1
Total Atoms	22
Total Chiral Atoms	3
Total Bonds	23
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P30988
Sequence	>9BUC_nogp_Chain_R Y V V G R K K M M D A Q Y K C Y D R Y C N R T W D G W L C W D D T P A G V L S Y Q F C P D Y F P D F D P S E K V T K Y C D E K G V W F K H P E N N R T W S N Y T M C N A F T P E K L K N A Y V L Y Y L A I V G H S L S I F T L V I S L G I F V F F R S L G C Q R V T L H K N M F L T Y I L N S M I I I I H L V E V V P N G E L V R R D P V S C K I L H F F H Q Y M M A C N Y F W M L C E G I Y L H T L I V V A V F T E K Q R L R W Y Y L L G W G F P L V P T T I H A I T R A V Y F N D N C W L S V E T H L L Y I I H G P V M A A L V V N F F F L L N I V R V L V T K M R E T H E A E S H M Y L K A V K A T M I L V P L L G I Q F V V F P W R P S N K M L G K I Y D Y V M H S L I H F Q G F F V A T I Y C F C N N E V Q T T V K R Q W A Q F K I Q W Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7X5H	A	Amine	5-Hydroxytryptamine	5-HT_5A	Homo sapiens	5-CT	-	Gi1/β1/γ2	3.1	2022-09-14	doi.org/10.1038/s41421-022-00412-3
	7X5H (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_5A	Homo sapiens	5-CT	-		3.1	2022-09-14	doi.org/10.1038/s41421-022-00412-3
	7UM5	A	Amine	5-Hydroxytryptamine	5-HT_5A	Homo sapiens	5-CT	-	chim(NtGi1-Go)/β1/γ2	2.73	2022-07-20	doi.org/10.1038/s41594-022-00796-6
	7UM5 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_5A	Homo sapiens	5-CT	-		2.73	2022-07-20	doi.org/10.1038/s41594-022-00796-6
	7XTC	A	Amine	5-Hydroxytryptamine	5-HT₇	Homo sapiens	5-CT	-	Gs/β1/γ2	3.2	2022-07-27	doi.org/10.1016/j.molcel.2022.05.031
	7XTC (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT₇	Homo sapiens	5-CT	-		3.2	2022-07-27	doi.org/10.1016/j.molcel.2022.05.031
	6E67	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	-	Gs(CT)	3.7	2019-06-05	doi.org/10.1016/j.cell.2019.04.021
	6NIY	B1	Peptide	Calcitonin	CT	Homo sapiens	Adrenomedullin	-	Gs/β1/γ2	3.34	2019-01-23	doi.org/10.1021/acsptsci.8b00056
	6NIY (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	Adrenomedullin	-		3.34	2019-01-23	doi.org/10.1021/acsptsci.8b00056
	5UZ7	B1	Peptide	Calcitonin	CT	Homo sapiens	-	-	Gs/β1/γ2	4.1	2017-05-03	doi.org/10.1038/nature22327
	5UZ7 (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	-	-		4.1	2017-05-03	doi.org/10.1038/nature22327
	8F0J	B1	Peptide	Calcitonin	CT	Homo sapiens	Pramlintide Analogue San45	-	Gs/β1/γ2	2	2023-08-02	doi.org/10.1038/s41589-023-01393-4
	8F0J (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	Pramlintide Analogue San45	-		2	2023-08-02	doi.org/10.1038/s41589-023-01393-4
	7TYL	B1	Peptide	Calcitonin	CT	Homo sapiens	Amylin	-	Gs/β1/γ2	3.3	2022-03-23	doi.org/10.1126/science.abm9609
	7TYL (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	Amylin	-		3.3	2022-03-23	doi.org/10.1126/science.abm9609
	7TYO	B1	Peptide	Calcitonin	CT	Homo sapiens	Calcitonin	-	Gs/β1/γ2	2.7	2022-03-23	doi.org/10.1126/science.abm9609
	7TYO (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	Calcitonin	-		2.7	2022-03-23	doi.org/10.1126/science.abm9609
	7TYI	B1	Peptide	Calcitonin	CT	Homo sapiens	Amylin	-	Gs/β1/γ2	3.3	2022-03-30	doi.org/10.1126/science.abm9609
	7TYI (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	Amylin	-		3.3	2022-03-30	doi.org/10.1126/science.abm9609
	7TYN	B1	Peptide	Calcitonin	CT	Homo sapiens	Calcitonin-1	-	Gs/β1/γ2	2.6	2022-03-30	doi.org/10.1126/science.abm9609
	7TYN (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	Calcitonin-1	-		2.6	2022-03-30	doi.org/10.1126/science.abm9609
	9BUB	B1	Peptide	Calcitonin	CT	Homo sapiens	Cagrilintide	-	Gs/β1/γ2	2.3	2025-04-23	doi.org/10.1038/s41467-025-58680-y
	9BUB (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	Cagrilintide	-		2.3	2025-04-23	doi.org/10.1038/s41467-025-58680-y
	9BLB	B1	Peptide	Calcitonin	CT	Homo sapiens	Cagrilintide backbone (non-acylated)	-	Gs/β1/γ2	3.2	2025-04-16	To be published
	9BLB (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	Cagrilintide backbone (non-acylated)	-		3.2	2025-04-16	To be published
	9BLC	B1	Peptide	Calcitonin	CT	Homo sapiens	Cagrilintide backbone (non-acylated)	-	Gs/β1/γ2	3.3	2025-04-16	To be published
	9BLC (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	Cagrilintide backbone (non-acylated)	-		3.3	2025-04-16	To be published
	9BUE	B1	Peptide	Calcitonin	CT	Homo sapiens	Cagrilintide	-	Gs/β1/γ2	3.6	2025-04-16	To be published
	9BUE (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	Cagrilintide	-		3.6	2025-04-16	To be published
	9BUC	B1	Peptide	Calcitonin	CT	Homo sapiens	Cagrilintide	-	Gs/β1/γ2	3.4	2025-04-23	To be published
	9BUC (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	Cagrilintide	-		3.4	2025-04-23	To be published
	9BUD	B1	Peptide	Calcitonin	CT	Homo sapiens	Cagrilintide	-	Gs/β1/γ2	2.5	2025-04-23	To be published
	9BUD (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	Cagrilintide	-		2.5	2025-04-23	To be published
	9AUC	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Calcitonin gene-related peptide-1	-	Gs/β1/γ2; RAMP1	2.4	2024-04-24	doi.org/10.1021/acs.biochem.4c00114
	9AUC (No Gprot)	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Calcitonin gene-related peptide-1	-		2.4	2024-04-24	doi.org/10.1021/acs.biochem.4c00114
	7TYF	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Amylin	-	Gs/β1/γ2; RAMP1	2.2	2022-03-23	doi.org/10.1126/science.abm9609
	7TYF (No Gprot)	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Amylin	-		2.2	2022-03-23	doi.org/10.1126/science.abm9609
	7TYW	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Calcitonin-1	-	Gs/β1/γ2; RAMP1	3	2022-03-23	doi.org/10.1126/science.abm9609
	7TYW (No Gprot)	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Calcitonin-1	-		3	2022-03-23	doi.org/10.1126/science.abm9609
	9BLW	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Cagrilintide backbone (non-acylated)	-	Gs/β1/γ2; RAMP1	3.2	2025-04-16	To be published
	9BLW (No Gprot)	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Cagrilintide backbone (non-acylated)	-		3.2	2025-04-16	To be published
	9BP3	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Cagrilintide	-	Gs/β1/γ2; RAMP1	2.2	2025-04-23	To be published
	9BP3 (No Gprot)	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Cagrilintide	-		2.2	2025-04-23	To be published
	7TYH	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Calcitonin-1	-	Gs/β1/γ2; RAMP2	3.3	2022-03-23	doi.org/10.1126/science.abm9609
	7TYH (No Gprot)	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Calcitonin-1	-		3.3	2022-03-23	doi.org/10.1126/science.abm9609
	7TYY	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Calcitonin-1	-	Gs/β1/γ2; RAMP2	3	2022-03-23	doi.org/10.1126/science.abm9609
	7TYY (No Gprot)	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Calcitonin-1	-		3	2022-03-23	doi.org/10.1126/science.abm9609
	7TYX	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Amylin	-	Gs/β1/γ2; RAMP2	2.55	2022-03-30	doi.org/10.1126/science.abm9609
	7TYX (No Gprot)	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Amylin	-		2.55	2022-03-30	doi.org/10.1126/science.abm9609
	9BQ3	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Cagrilintide	-	Gs/β1/γ2; RAMP2	2.8	2025-04-23	To be published
	9BQ3 (No Gprot)	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Cagrilintide	-		2.8	2025-04-23	To be published
	8F0K	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Pramlintide Analogue San385	-	Gs/β1/γ2; RAMP3	1.9	2023-08-02	doi.org/10.1038/s41589-023-01393-4
	8F0K (No Gprot)	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Pramlintide Analogue San385	-		1.9	2023-08-02	doi.org/10.1038/s41589-023-01393-4
	8F2A	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Pramlintide Analogue San385	-	Gs/β1/γ2; RAMP3	2.2	2023-08-02	doi.org/10.1038/s41589-023-01393-4
	8F2A (No Gprot)	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Pramlintide Analogue San385	-		2.2	2023-08-02	doi.org/10.1038/s41589-023-01393-4
	8F2B	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Pramlintide Analogue San45	-	Gs/β1/γ2; RAMP3	2	2023-08-02	doi.org/10.1038/s41589-023-01393-4
	8F2B (No Gprot)	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Pramlintide Analogue San45	-		2	2023-08-02	doi.org/10.1038/s41589-023-01393-4
	7TZF	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Amylin	-	Gs/β1/γ2; RAMP3	2.4	2022-03-23	doi.org/10.1126/science.abm9609
	7TZF (No Gprot)	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Amylin	-		2.4	2022-03-23	doi.org/10.1126/science.abm9609
	9BTW	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Cagrilintide	-	Gs/β1/γ2; RAMP3	3	2025-04-16	To be published
	9BTW (No Gprot)	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Cagrilintide	-		3	2025-04-16	To be published
	6E3Y	B1	Peptide	Calcitonin	CT Like	Homo sapiens	Calcitonin gene-related peptide-1	-	Gs/β1/γ2; RAMP1	3.3	2018-09-19	doi.org/10.1038/s41586-018-0535-y
	6E3Y (No Gprot)	B1	Peptide	Calcitonin	CT Like	Homo sapiens	Calcitonin gene-related peptide-1	-		3.3	2018-09-19	doi.org/10.1038/s41586-018-0535-y
	7KNT	B1	Peptide	Calcitonin	CT Like	Homo sapiens	-	-	RAMP1	3.15	2021-02-24	doi.org/10.1126/science.abf7258
	7KNU	B1	Peptide	Calcitonin	CT Like	Homo sapiens	Calcitonin gene-related peptide-1	-	RAMP1	3.49	2021-02-24	doi.org/10.1126/science.abf7258
	6UUN	B1	Peptide	Calcitonin	CT Like (AM1)	Homo sapiens	Adrenomedullin	-	Gs/β1/γ2; RAMP2	3	2020-03-25	doi.org/10.1021/acsptsci.9b00080
	6UUN (No Gprot)	B1	Peptide	Calcitonin	CT Like (AM1)	Homo sapiens	Adrenomedullin	-		3	2020-03-25	doi.org/10.1021/acsptsci.9b00080
	6UUS	B1	Peptide	Calcitonin	CT Like (AM2)	Homo sapiens	Adrenomedullin	-	Gs/β1/γ2; RAMP3	2.4	2020-04-01	doi.org/10.1021/acsptsci.9b00080
	6UUS (No Gprot)	B1	Peptide	Calcitonin	CT Like (AM2)	Homo sapiens	Adrenomedullin	-		2.4	2020-04-01	doi.org/10.1021/acsptsci.9b00080
	6UVA	B1	Peptide	Calcitonin	CT Like (AM2)	Homo sapiens	Adrenomedullin-2	-	Gs/β1/γ2; RAMP3	2.3	2020-04-01	doi.org/10.1021/acsptsci.9b00080
	6UVA (No Gprot)	B1	Peptide	Calcitonin	CT Like (AM2)	Homo sapiens	Adrenomedullin-2	-		2.3	2020-04-01	doi.org/10.1021/acsptsci.9b00080
	6PH7	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	Nerol	Gt(CT)	2.9	2020-07-01	To be published
	6PGS	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	Geraniol	Gt(CT)	2.9	2020-07-01	To be published
	6PEL	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	Citronellol	Gt(CT)	3.19	2020-06-24	To be published
	4J4Q	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl β-D-Glucopyranoside	-	Gt(CT)	2.65	2013-10-30	doi.org/10.1002/anie.201302374
	4X1H	A	Sensory	Opsins	Rhodopsin	Bos taurus	Nonyl-β-D-Glucopyranoside	-	Gt(CT)	2.29	2015-11-04	doi.org/10.1016/j.str.2015.09.015
	4BEY	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	Gt(CT)	2.9	2013-05-08	doi.org/10.1038/embor.2013.44
	3DQB	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	Gt(CT)	3.2	2008-09-23	doi.org/10.1038/nature07330
	3PQR	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gt(CT)	2.85	2011-03-09	doi.org/10.1038/nature09789
	2X72	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gt(CT)	3	2011-03-16	doi.org/10.1038/nature09795
	5WKT	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl-β-D-Glucopyranoside	-	Gt(CT)	3.2	2017-12-13	doi.org/10.1038/nprot.2017.135
	4A4M	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gt(CT)	3.3	2012-01-25	doi.org/10.1073/pnas.1114089108
	5EN0	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gt(CT)	2.81	2016-08-10	doi.org/10.15252/embr.201642671
	6NWE	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl-β-D-Glucopyranoside	-	Gt(CT)	2.71	2020-02-12	To be published
	6TP4	A	Peptide	Orexin	OX₁	Homo sapiens	ACT-462206	-	-	3.01	2020-01-01	doi.org/10.1021/acs.jmedchem.9b01787

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9BUC_nogp.zip

You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.

You can also read or download a guide explaining the meaning of all files and numerical data.