psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:C1	L:L:C7	7.28	Yes	No	1	0	0
2	L:L:C1	R:R:L298	7.94	Yes	No	0	0	6
3	L:L:C1	R:R:H302	13.27	Yes	Yes	1	0	6
4	L:L:N3	R:R:W361	15.82	No	No	0	0	4
5	L:L:N3	R:R:R362	4.82	No	Yes	0	0	4
6	L:L:S5	R:R:F356	6.61	No	Yes	0	0	7
7	L:L:T6	R:R:Y234	7.49	Yes	Yes	1	0	7
8	L:L:T6	R:R:H302	6.85	Yes	Yes	1	0	6
9	L:L:T6	R:R:V305	4.76	Yes	No	1	0	7
10	L:L:T6	R:R:M306	7.53	Yes	No	0	0	4
11	L:L:T6	R:R:F356	6.49	Yes	Yes	1	0	7
12	L:L:C7	R:R:H302	13.27	No	Yes	1	0	6
13	L:L:M8	R:R:D373	5.54	No	No	0	0	5
14	L:L:M8	R:R:M376	4.33	No	Yes	0	0	7
15	L:L:M8	R:R:H377	6.57	No	Yes	0	0	7
16	L:L:L9	R:R:I198	4.28	No	Yes	0	0	7
17	L:L:F16	L:L:Y12	9.28	Yes	Yes	4	0	0
18	L:L:Y12	R:R:A145	4	Yes	No	0	0	4
19	L:L:Y12	R:R:L148	5.86	Yes	Yes	4	0	5
20	L:L:Y12	R:R:Y149	5.96	Yes	Yes	4	0	5
21	L:L:Y12	R:R:H377	5.44	Yes	Yes	4	0	7
22	L:L:T13	R:R:H201	5.48	No	Yes	0	0	6
23	L:L:D15	L:L:Q14	6.53	No	Yes	0	0	0
24	L:L:K18	L:L:Q14	9.49	No	Yes	0	0	0
25	L:L:Q14	R:R:V293	4.3	Yes	No	0	0	6
26	L:L:Q14	R:R:E294	6.37	Yes	No	0	0	3
27	L:L:F16	L:L:H20	7.92	Yes	No	0	0	0
28	L:L:F16	R:R:Y146	5.16	Yes	No	0	0	2
29	L:L:F16	R:R:Y149	10.32	Yes	Yes	4	0	5
30	L:L:F16	R:R:V206	5.24	Yes	No	0	0	3
31	L:L:N17	L:L:T21	10.24	No	Yes	2	0	0
32	L:L:N17	R:R:V212	7.39	No	No	2	0	3
33	L:L:N17	R:R:L291	4.12	No	No	0	0	6
34	L:L:F19	L:L:H20	5.66	No	No	0	0	0
35	L:L:F19	R:R:L142	9.74	No	No	0	0	2
36	L:L:F22	L:L:T21	7.78	Yes	Yes	2	0	0
37	L:L:T21	R:R:G209	5.46	Yes	No	0	0	3
38	L:L:T21	R:R:V212	4.76	Yes	No	2	0	3
39	L:L:F22	R:R:L40	4.87	Yes	No	0	0	5
40	L:L:F22	R:R:Y41	11.35	Yes	No	2	0	3
41	L:L:F22	R:R:P100	13	Yes	No	2	0	4
42	L:L:Q24	R:R:D101	10.44	No	No	0	0	4
43	L:L:Q24	R:R:N135	3.96	No	No	0	0	3
44	L:L:T25	R:R:F99	10.38	No	No	0	0	5
45	L:L:T25	R:R:D101	5.78	No	No	0	0	4
46	L:L:T25	R:R:F102	6.49	No	Yes	0	0	4
47	L:L:I27	R:R:N135	14.16	No	No	0	0	3
48	L:L:?33	L:L:P32	12.19	No	No	6	0	0
49	L:L:P32	R:R:G78	4.06	No	No	6	0	5
50	L:L:P32	R:R:W79	4.05	No	Yes	6	0	6
51	L:L:?33	R:R:G78	4.23	No	No	6	0	5
52	L:L:?33	R:R:Y131	11.61	No	Yes	0	0	5
53	R:R:N288	R:R:P38	4.89	No	No	0	4	5
54	R:R:F39	R:R:V43	3.93	No	No	0	4	2
55	R:R:F285	R:R:F39	6.43	Yes	No	0	6	4
56	R:R:L40	R:R:S292	4.5	No	No	0	5	4
57	R:R:P100	R:R:Y41	8.34	No	No	2	4	3
58	R:R:R45	R:R:V42	6.54	No	No	0	7	1
59	R:R:K46	R:R:M49	5.76	No	No	0	4	4
60	R:R:D50	R:R:K46	4.15	No	No	0	2	4
61	R:R:D97	R:R:K47	8.3	No	No	0	2	4
62	R:R:K47	R:R:Y98	5.97	No	Yes	0	4	4
63	R:R:M48	R:R:W76	4.65	No	No	0	6	8
64	R:R:M48	R:R:W79	4.65	No	Yes	0	6	6
65	R:R:M49	R:R:Q52	4.08	No	No	11	4	6
66	R:R:M49	R:R:Y53	8.38	No	No	11	4	1
67	R:R:Q52	R:R:Y53	7.89	No	No	11	6	1
68	R:R:Q52	R:R:W76	14.24	No	No	0	6	8
69	R:R:C55	R:R:C81	7.28	No	No	0	9	9
70	R:R:Q60	R:R:Y56	16.91	No	No	0	3	3
71	R:R:C72	R:R:T85	5.07	No	Yes	5	9	7
72	R:R:C112	R:R:C72	7.28	No	No	0	9	9
73	R:R:C72	R:R:W118	20.89	No	Yes	5	9	9
74	R:R:N73	R:R:W118	5.65	No	Yes	0	4	9
75	R:R:D83	R:R:R74	8.34	No	No	0	5	4
76	R:R:D77	R:R:T75	5.78	No	No	0	9	5
77	R:R:C81	R:R:W76	6.53	No	No	0	9	8
78	R:R:D77	R:R:K110	4.15	No	Yes	0	9	8
79	R:R:D77	R:R:T127	8.67	No	No	0	9	4
80	R:R:G78	R:R:W79	5.63	No	Yes	6	5	6
81	R:R:W79	R:R:Y98	4.82	Yes	Yes	0	6	4
82	R:R:F99	R:R:W79	8.02	No	Yes	0	5	6
83	R:R:L80	R:R:W82	4.56	No	Yes	0	5	9
84	R:R:L80	R:R:P96	11.49	No	No	0	5	9
85	R:R:L80	R:R:Y131	5.86	No	Yes	0	5	5
86	R:R:S91	R:R:W82	8.65	No	Yes	0	5	9
87	R:R:Q93	R:R:W82	6.57	No	Yes	0	6	9
88	R:R:K110	R:R:W82	22.05	Yes	Yes	5	8	9
89	R:R:W118	R:R:W82	4.69	Yes	Yes	5	9	9
90	R:R:T85	R:R:W118	6.06	Yes	Yes	5	7	9
91	R:R:P86	R:R:V89	5.3	No	No	0	2	5
92	R:R:L90	R:R:Y111	4.69	No	Yes	0	4	4
93	R:R:K107	R:R:Y92	7.17	No	No	0	3	4
94	R:R:C134	R:R:C95	7.28	No	No	0	9	9
95	R:R:P96	R:R:Y98	5.56	No	Yes	0	9	4
96	R:R:F102	R:R:P96	5.78	Yes	No	0	4	9
97	R:R:D97	R:R:P104	4.83	No	No	0	2	3
98	R:R:F99	R:R:P100	4.33	No	No	0	5	4
99	R:R:F102	R:R:Y131	7.22	Yes	Yes	0	4	5
100	R:R:C134	R:R:F102	11.17	No	Yes	0	9	4
101	R:R:D103	R:R:P104	9.66	No	No	0	3	3
102	R:R:D103	R:R:S105	4.42	No	No	0	3	1
103	R:R:K366	R:R:S105	6.12	No	No	0	3	1
104	R:R:E106	R:R:M133	9.47	No	No	0	4	5
105	R:R:V108	R:R:Y131	5.05	No	Yes	0	7	5
106	R:R:N130	R:R:T109	8.77	Yes	No	0	8	5
107	R:R:K110	R:R:W118	10.44	Yes	Yes	5	8	9
108	R:R:K110	R:R:S129	10.71	Yes	No	0	8	7
109	R:R:D113	R:R:Y111	9.2	No	Yes	0	5	4
110	R:R:F119	R:R:Y111	4.13	No	Yes	0	4	4
111	R:R:H121	R:R:P122	9.15	No	No	0	4	5
112	R:R:E123	R:R:H121	8.62	No	No	0	4	4
113	R:R:H121	R:R:N124	20.41	No	No	0	4	5
114	R:R:N124	R:R:R126	7.23	No	No	0	5	4
115	R:R:N130	R:R:W128	7.91	Yes	No	8	8	5
116	H:H:?1	R:R:W128	4.09	No	No	8	0	5
117	R:R:S129	R:R:Y131	6.36	No	Yes	0	7	5
118	R:R:N130	R:R:T132	10.24	Yes	Yes	8	8	6
119	H:H:?1	R:R:N130	25.87	No	Yes	8	0	8
120	R:R:M133	R:R:T132	4.52	No	Yes	0	5	6
121	H:H:?1	R:R:T132	17.19	No	Yes	8	0	6
122	R:R:F137	R:R:M133	4.98	No	No	0	1	5
123	R:R:F137	R:R:K141	4.96	No	No	0	1	3
124	R:R:L142	R:R:Y146	7.03	No	No	0	2	2
125	R:R:N144	R:R:Y374	5.81	No	Yes	0	4	6
126	R:R:Y146	R:R:Y150	3.97	No	No	0	2	4
127	R:R:H377	R:R:L148	6.43	Yes	Yes	4	7	5
128	R:R:Y149	R:R:Y150	3.97	Yes	No	0	5	4
129	R:R:I153	R:R:Y149	4.84	No	Yes	0	7	5
130	R:R:L202	R:R:Y149	4.69	No	Yes	0	7	5
131	R:R:P207	R:R:Y149	6.95	No	Yes	0	3	5
132	R:R:A152	R:R:H381	7.32	No	No	0	7	9
133	R:R:F382	R:R:G155	9.03	No	No	0	7	8
134	R:R:H156	R:R:S195	5.58	Yes	No	0	7	7
135	R:R:H156	R:R:I198	11.93	Yes	Yes	0	7	7
136	R:R:H156	R:R:H381	11.94	Yes	No	0	7	9
137	R:R:F385	R:R:L158	14.61	Yes	No	0	5	4
138	R:R:I160	R:R:S195	6.19	No	No	0	5	7
139	R:R:F161	R:R:I165	5.02	No	No	0	4	5
140	R:R:F385	R:R:T162	10.38	Yes	No	0	5	6
141	R:R:F393	R:R:T162	5.19	Yes	No	0	8	6
142	R:R:F188	R:R:L163	4.87	No	No	0	8	8
143	R:R:I192	R:R:L163	4.28	No	No	0	7	8
144	R:R:C392	R:R:S166	6.89	Yes	No	12	9	9
145	R:R:F393	R:R:S166	5.28	Yes	No	12	8	9
146	R:R:F170	R:R:L176	4.87	Yes	Yes	0	8	9
147	R:R:F170	R:R:V181	9.18	Yes	No	0	8	9
148	R:R:F170	R:R:F188	5.36	Yes	No	0	8	8
149	R:R:C392	R:R:F170	5.59	Yes	Yes	0	9	8
150	R:R:F172	R:R:F173	8.57	No	No	0	2	7
151	R:R:F173	R:R:Q405	5.86	No	No	0	7	4
152	R:R:E397	R:R:L176	3.98	No	Yes	0	9	9
153	R:R:L176	R:R:V398	5.96	Yes	No	0	9	9
154	R:R:L176	R:R:T401	4.42	Yes	No	0	9	7
155	R:R:C178	R:R:R180	5.57	No	No	0	8	9
156	R:R:Q179	R:R:Y243	9.02	No	Yes	0	7	8
157	R:R:L259	R:R:Q179	7.99	No	No	0	5	7
158	R:R:K185	R:R:V181	4.55	No	No	0	6	9
159	R:R:L183	R:R:W236	4.56	No	Yes	3	8	9
160	R:R:L183	R:R:Y243	5.86	No	Yes	3	8	8
161	R:R:L183	R:R:Y262	4.69	No	No	3	8	7
162	R:R:E240	R:R:H184	16	No	No	0	9	9
163	R:R:H184	R:R:Y391	8.71	No	No	0	9	8
164	R:R:N186	R:R:W236	12.43	No	Yes	3	9	9
165	R:R:N186	R:R:Y263	6.98	No	No	0	9	5
166	R:R:N186	R:R:W267	6.78	No	No	3	9	9
167	R:R:M187	R:R:Y191	7.18	No	Yes	0	8	8
168	R:R:E240	R:R:M187	12.18	No	No	0	9	8
169	R:R:L189	R:R:L193	6.92	No	No	0	3	6
170	R:R:N233	R:R:T190	7.31	Yes	No	0	9	9
171	R:R:N233	R:R:Y191	13.96	Yes	Yes	9	9	8
172	R:R:M237	R:R:Y191	5.99	No	Yes	9	9	8
173	R:R:Q383	R:R:Y191	13.53	No	Yes	9	9	8
174	R:R:G384	R:R:Y191	8.69	No	Yes	0	9	8
175	R:R:V387	R:R:Y191	6.31	No	Yes	0	9	8
176	R:R:I192	R:R:M196	4.37	No	No	0	7	4
177	R:R:L193	R:R:M229	9.9	No	No	0	6	4
178	R:R:I198	R:R:N194	5.66	Yes	No	0	7	8
179	R:R:M229	R:R:N194	4.21	No	No	0	4	8
180	R:R:N194	R:R:N233	9.54	No	Yes	0	8	9
181	R:R:H226	R:R:I197	3.98	No	No	0	6	5
182	R:R:H226	R:R:I198	5.3	No	Yes	0	6	7
183	R:R:H201	R:R:V205	12.45	Yes	No	0	6	7
184	R:R:H201	R:R:V206	5.54	Yes	No	0	6	3
185	R:R:E204	R:R:V203	4.28	No	No	0	4	3
186	R:R:P207	R:R:V206	5.3	No	No	0	3	3
187	R:R:E210	R:R:N208	6.57	No	No	0	3	3
188	R:R:E210	R:R:R213	4.65	No	No	0	3	2
189	R:R:L211	R:R:R214	6.07	No	No	0	1	4
190	R:R:C289	R:R:V212	5.12	No	No	0	9	3
191	R:R:D215	R:R:K220	4.15	No	No	0	6	7
192	R:R:D215	R:R:N288	13.46	No	No	0	6	4
193	R:R:P216	R:R:S218	5.34	No	No	0	4	3
194	R:R:C219	R:R:P216	7.53	No	No	0	9	4
195	R:R:C219	R:R:C289	7.28	No	No	0	9	9
196	R:R:K220	R:R:N286	5.6	No	No	0	7	7
197	R:R:K220	R:R:W290	22.05	No	Yes	0	7	9
198	R:R:H223	R:R:Q227	8.65	No	Yes	0	5	7
199	R:R:H223	R:R:W290	10.58	No	Yes	0	5	9
200	R:R:F224	R:R:F225	4.29	Yes	No	0	5	5
201	R:R:F224	R:R:T274	5.19	Yes	No	0	5	6
202	R:R:H226	R:R:Q227	4.95	No	Yes	0	6	7
203	R:R:M230	R:R:Q227	5.44	No	Yes	0	6	7
204	R:R:I301	R:R:Q227	4.12	No	Yes	0	7	7
205	R:R:C232	R:R:Y228	9.41	No	No	0	8	8
206	R:R:L271	R:R:Y228	8.21	No	No	0	4	8
207	R:R:M230	R:R:Y234	5.99	No	Yes	0	6	7
208	R:R:H302	R:R:M230	3.94	Yes	No	0	6	6
209	R:R:C232	R:R:W267	3.92	No	No	0	8	9
210	R:R:C232	R:R:P270	7.53	No	Yes	0	8	9
211	R:R:M237	R:R:N233	4.21	No	Yes	9	9	9
212	R:R:V305	R:R:Y234	8.83	No	Yes	1	7	7
213	R:R:F356	R:R:Y234	12.38	Yes	Yes	1	7	7
214	R:R:F235	R:R:F269	8.57	Yes	No	13	5	3
215	R:R:F235	R:R:P270	5.78	Yes	Yes	13	5	9
216	R:R:A308	R:R:F235	4.16	No	Yes	0	7	5
217	R:R:C239	R:R:W236	6.53	No	Yes	0	7	9
218	R:R:G266	R:R:W236	8.44	No	Yes	0	9	9
219	R:R:W236	R:R:W267	17.81	Yes	No	3	9	9
220	R:R:M237	R:R:Q383	5.44	No	No	9	9	9
221	R:R:I242	R:R:L238	7.14	No	No	0	7	8
222	R:R:A308	R:R:L238	4.73	No	No	0	7	8
223	R:R:L238	R:R:N312	9.61	No	No	0	8	9
224	R:R:C239	R:R:L265	4.76	No	No	0	7	7
225	R:R:E240	R:R:L351	9.28	No	No	0	9	9
226	R:R:L247	R:R:Y243	14.07	No	Yes	0	8	8
227	R:R:Y243	R:R:Y262	6.95	Yes	No	3	8	7
228	R:R:I248	R:R:L244	4.28	No	No	0	7	9
229	R:R:I319	R:R:L244	4.28	No	No	0	9	9
230	R:R:H245	R:R:V249	15.22	Yes	No	0	8	6
231	R:R:H245	R:R:V250	4.15	Yes	No	0	8	5
232	R:R:F315	R:R:H245	23.76	No	Yes	0	8	8
233	R:R:H245	R:R:N318	7.65	Yes	No	0	8	8
234	R:R:Q257	R:R:T246	5.67	No	No	0	5	7
235	R:R:Q257	R:R:Y262	7.89	No	No	0	5	7
236	R:R:R258	R:R:R260	7.46	No	No	0	5	3
237	R:R:R258	R:R:W261	16.99	No	No	0	5	2
238	R:R:L259	R:R:Y263	4.69	No	No	0	5	5
239	R:R:F269	R:R:P270	4.33	No	Yes	13	3	9
240	R:R:I276	R:R:I300	4.42	No	No	0	5	8
241	R:R:H277	R:R:L298	10.29	No	No	0	7	6
242	R:R:H277	R:R:I301	11.93	No	No	0	7	7
243	R:R:L297	R:R:T280	7.37	No	No	0	4	4
244	R:R:F285	R:R:R281	4.28	Yes	Yes	7	6	7
245	R:R:D287	R:R:R281	8.34	No	Yes	7	3	7
246	R:R:R281	R:R:W290	16.99	Yes	Yes	0	7	9
247	R:R:R281	R:R:T295	6.47	Yes	Yes	7	7	4
248	R:R:V283	R:R:Y284	12.62	No	No	0	3	2
249	R:R:D287	R:R:F285	7.17	No	Yes	7	3	6
250	R:R:F285	R:R:T295	7.78	Yes	Yes	7	6	4
251	R:R:D287	R:R:S292	11.78	No	No	0	3	4
252	R:R:C289	R:R:L291	4.76	No	No	0	9	6
253	R:R:L297	R:R:T295	4.42	No	Yes	0	4	4
254	R:R:L298	R:R:T295	4.42	No	Yes	0	6	4
255	R:R:G303	R:R:P304	4.06	No	No	0	4	9
256	R:R:F315	R:R:V311	5.24	No	No	0	8	6
257	R:R:L352	R:R:N312	5.49	Yes	No	0	9	9
258	R:R:F313	R:R:L317	7.31	No	No	0	6	5
259	R:R:F313	R:R:V357	6.55	No	No	0	6	7
260	R:R:L316	R:R:L348	4.15	No	No	0	9	9
261	R:R:I354	R:R:L316	5.71	No	No	0	6	9
262	R:R:K326	R:R:V322	4.55	No	No	0	9	8
263	R:R:M337	R:R:V324	4.56	Yes	No	0	7	5
264	R:R:E332	R:R:M327	9.47	No	Yes	0	5	7
265	R:R:M327	R:R:M337	7.22	Yes	Yes	0	7	7
266	R:R:E332	R:R:H336	4.92	No	No	0	5	6
267	R:R:A333	R:R:H336	4.39	No	No	0	5	6
268	R:R:H336	R:R:S335	5.58	No	No	0	6	6
269	R:R:K343	R:R:M346	8.64	No	No	0	8	8
270	R:R:I347	R:R:I390	5.89	No	No	0	8	8
271	R:R:I354	R:R:V349	9.22	No	No	0	6	8
272	R:R:L351	R:R:L352	4.15	No	Yes	0	9	9
273	R:R:L351	R:R:Y391	15.24	No	No	0	9	8
274	R:R:I354	R:R:L352	4.28	No	Yes	0	6	9
275	R:R:G353	R:R:Q355	4.93	No	Yes	0	9	8
276	R:R:F356	R:R:Q355	9.37	Yes	Yes	0	7	8
277	R:R:L379	R:R:Q355	3.99	No	Yes	0	5	8
278	R:R:Q355	R:R:Q383	10.24	Yes	No	0	8	9
279	R:R:F356	R:R:I380	10.05	Yes	No	0	7	6
280	R:R:F359	R:R:V358	5.24	No	No	0	6	5
281	R:R:F359	R:R:Y372	5.16	No	Yes	10	6	7
282	R:R:F359	R:R:M376	4.98	No	Yes	10	6	7
283	R:R:G369	R:R:R362	4.5	No	Yes	0	4	4
284	R:R:R362	R:R:Y372	9.26	Yes	Yes	0	4	7
285	R:R:D373	R:R:R362	13.1	No	Yes	0	5	4
286	R:R:G369	R:R:P363	4.06	No	No	0	4	7
287	R:R:P363	R:R:Y372	5.56	No	Yes	0	7	7
288	R:R:L368	R:R:N365	8.24	No	No	0	3	4
289	R:R:K370	R:R:Y374	7.17	No	Yes	0	4	6
290	R:R:M376	R:R:Y372	10.78	Yes	Yes	10	7	7
291	R:R:H377	R:R:H381	9.55	Yes	No	0	7	9
292	R:R:F382	R:R:F386	4.29	No	No	0	7	5
293	R:R:F385	R:R:F386	4.29	Yes	No	0	5	5
294	R:R:F385	R:R:T389	5.19	Yes	No	0	5	5
295	R:R:F393	R:R:T389	6.49	Yes	No	0	8	5
296	R:R:I390	R:R:Y391	4.84	No	No	0	8	8
297	R:R:C392	R:R:F393	4.19	Yes	Yes	12	9	8
298	R:R:N395	R:R:V398	7.39	No	No	0	9	9
299	R:R:N396	R:R:Q399	3.96	No	No	0	6	7
300	R:R:Q405	R:R:R404	9.35	No	No	0	4	7
301	L:L:T21	R:R:R213	3.88	Yes	No	0	0	2
302	R:R:H201	R:R:L222	3.86	Yes	No	0	6	6
303	R:R:V147	R:R:Y374	3.79	No	Yes	0	4	6
304	R:R:F315	R:R:I242	3.77	No	No	0	8	7
305	R:R:T109	R:R:Y92	3.75	No	No	0	5	4
306	L:L:F22	L:L:K18	3.72	Yes	No	0	0	0
307	R:R:M59	R:R:R74	3.72	No	No	0	5	4
308	R:R:G384	R:R:S159	3.71	No	No	0	9	9
309	R:R:F356	R:R:L309	3.65	Yes	No	0	7	7
310	R:R:N125	R:R:R126	3.62	No	No	0	7	4
311	R:R:M337	R:R:Y338	3.59	Yes	No	0	7	7
312	R:R:D84	R:R:R74	3.57	No	No	0	4	4
313	R:R:P273	R:R:V272	3.53	No	No	0	6	4
314	R:R:P350	R:R:V349	3.53	No	No	0	9	8
315	R:R:L90	R:R:Y92	3.52	No	No	0	4	4
316	R:R:L148	R:R:Y374	3.52	Yes	Yes	0	5	6
317	R:R:L163	R:R:Y191	3.52	No	Yes	0	8	8
318	R:R:P139	R:R:T138	3.5	No	No	0	3	2
319	R:R:G44	R:R:K47	3.49	No	No	0	4	4
320	L:L:L4	R:R:W361	3.42	No	No	0	0	4
321	R:R:A388	R:R:S166	3.42	No	No	0	8	9
322	R:R:C178	R:R:V181	3.42	No	No	0	8	9
323	R:R:L211	R:R:P216	3.28	No	No	0	1	4
324	R:R:L368	R:R:P363	3.28	No	No	0	3	7
325	R:R:C392	R:R:I169	3.27	Yes	No	0	9	8
326	R:R:T345	R:R:V320	3.17	No	No	0	9	7
327	R:R:I192	R:R:V164	3.07	No	No	0	7	4
328	R:R:I248	R:R:V249	3.07	No	No	0	7	6
329	R:R:I248	R:R:V322	3.07	No	No	0	7	8
330	L:L:I27	R:R:T132	3.04	No	Yes	0	0	6
331	L:L:V29	R:R:N124	2.96	No	No	0	0	5
332	R:R:L259	R:R:T182	2.95	No	No	0	5	5
333	R:R:L316	R:R:T345	2.95	No	No	0	9	9
334	R:R:I371	R:R:M367	2.92	No	No	0	5	4
335	R:R:K340	R:R:M327	2.88	No	Yes	0	8	7
336	R:R:I200	R:R:L222	2.85	No	No	0	6	6
337	L:L:Q24	R:R:T138	2.83	No	No	0	0	2
338	R:R:L323	R:R:M327	2.83	No	Yes	0	9	7
339	R:R:K185	R:R:L167	2.82	No	No	0	6	6
340	R:R:M367	R:R:N365	2.8	No	No	0	4	4
341	R:R:D50	R:R:K54	2.77	No	No	0	2	4
342	R:R:A278	R:R:F224	2.77	No	Yes	0	6	5
343	R:R:E204	R:R:I200	2.73	No	No	0	4	6
344	L:L:C1	R:R:Y299	2.69	Yes	No	0	0	7
345	R:R:A51	R:R:Y98	2.67	No	Yes	0	8	4
346	R:R:H156	R:R:I199	2.65	Yes	No	0	7	7
347	R:R:H277	R:R:I300	2.65	No	No	0	7	8
348	R:R:F173	R:R:V402	2.62	No	No	0	7	5
349	R:R:F314	R:R:V310	2.62	No	No	0	5	4
350	R:R:F313	R:R:V358	2.62	No	No	0	6	5
351	R:R:R328	R:R:V324	2.62	No	No	0	6	5
352	L:L:A31	R:R:W128	2.59	No	No	0	0	5
353	R:R:F224	R:R:T275	2.59	Yes	No	0	5	3
354	R:R:A278	R:R:W290	2.59	No	Yes	0	6	9
355	R:R:A282	R:R:W290	2.59	No	Yes	0	3	9
356	R:R:R404	R:R:T401	2.59	No	No	0	7	7
357	R:R:Q405	R:R:Q408	2.56	No	No	0	4	7
358	R:R:F393	R:R:I165	2.51	Yes	No	0	8	5
359	R:R:F314	R:R:L317	2.44	No	No	0	5	5
360	R:R:N318	R:R:R321	2.41	No	No	0	8	8
361	R:R:L264	R:R:W261	2.28	No	No	0	3	2
362	R:R:H296	R:R:Y299	2.18	No	No	0	2	7
363	R:R:G268	R:R:P270	2.03	No	Yes	0	6	9
364	R:R:A231	R:R:P270	1.87	No	Yes	0	5	9
365	L:L:G2	R:R:V293	1.84	No	No	0	0	6
366	L:L:G10	R:R:V293	1.84	No	No	0	0	6
367	L:L:G30	L:L:V29	1.84	No	No	0	0	0
368	L:L:G2	L:L:T11	1.82	No	No	0	0	0
369	R:R:P86	R:R:T85	1.75	No	Yes	0	2	7
370	R:R:G241	R:R:L352	1.71	No	Yes	0	8	9
371	R:R:G268	R:R:L264	1.71	No	No	0	6	3
372	R:R:A251	R:R:V250	1.7	No	No	0	6	5
373	R:R:I300	R:R:P273	1.69	No	No	0	8	6
374	R:R:C394	R:R:T389	1.69	No	No	0	5	5
375	R:R:A251	R:R:T254	1.68	No	No	0	6	6
376	R:R:M306	R:R:P360	1.68	No	No	0	4	5
377	R:R:A344	R:R:L323	1.58	No	No	0	9	9
378	R:R:T400	R:R:T401	1.57	No	No	0	4	7
379	R:R:I153	R:R:S157	1.55	No	No	0	7	7
380	R:R:I199	R:R:S157	1.55	No	No	0	7	7
381	R:R:A136	R:R:D101	1.54	No	No	0	2	4
382	R:R:I221	R:R:V217	1.54	No	No	0	4	3
383	R:R:I279	R:R:V283	1.54	No	No	0	3	3
384	R:R:K120	R:R:V117	1.52	No	No	0	1	5
385	R:R:K185	R:R:V171	1.52	No	No	0	6	4
386	R:R:M376	R:R:V375	1.52	Yes	No	0	7	4
387	R:R:L151	R:R:S378	1.5	No	No	0	5	5
388	R:R:D113	R:R:V117	1.46	No	No	0	5	5
389	R:R:N396	R:R:T400	1.46	No	No	0	6	4
390	R:R:D83	R:R:T85	1.45	No	Yes	0	5	7
391	R:R:G88	R:R:Y111	1.45	No	Yes	0	8	4
392	L:L:F22	L:L:P23	1.44	Yes	No	0	0	0
393	R:R:F119	R:R:P122	1.44	No	No	0	4	5
394	R:R:F235	R:R:P304	1.44	Yes	No	0	5	9
395	R:R:C55	R:R:R58	1.39	No	No	0	9	3
396	R:R:L148	R:R:L151	1.38	Yes	No	0	5	5
397	R:R:E140	R:R:K143	1.35	No	No	0	2	1
398	R:R:E334	R:R:M337	1.35	No	Yes	0	6	7
399	R:R:E255	R:R:L247	1.33	No	No	0	6	8
400	R:R:F225	R:R:I221	1.26	No	No	0	5	4
401	R:R:T280	R:R:Y284	1.25	No	No	0	4	2
402	R:R:M59	R:R:Y56	1.2	No	No	0	5	3
403	R:R:D57	R:R:Y56	1.15	No	No	0	4	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:C1	7.795	4	1	0
2	L:L:T6	6.624	5	1	0
3	L:L:Y12	6.108	5	4	0
4	L:L:Q14	6.6725	4	0	0
5	L:L:F16	7.584	5	4	0
6	L:L:T21	6.424	5	2	0
7	L:L:F22	7.02667	6	2	0
8	R:R:W79	5.434	5	6	6
9	R:R:W82	9.304	5	5	9
10	R:R:T85	3.5825	4	5	7
11	R:R:Y98	4.755	4	0	4
12	R:R:F102	7.665	4	0	4
13	R:R:K110	11.8375	4	5	8
14	R:R:Y111	4.8675	4	0	4
15	R:R:W118	9.546	5	5	9
16	R:R:N130	13.1975	4	8	8
17	R:R:Y131	7.22	5	0	5
18	R:R:T132	8.7475	4	8	6
19	R:R:L148	4.2975	4	4	5
20	R:R:Y149	6.12167	6	4	5
21	R:R:H156	8.025	4	0	7
22	R:R:F170	6.25	4	0	8
23	R:R:L176	4.8075	4	0	9
24	R:R:Y191	8.45429	7	9	8
25	R:R:I198	6.7925	4	0	7
26	R:R:H201	6.8325	4	0	6
27	R:R:F224	3.71	4	0	5
28	R:R:Q227	5.79	4	0	7
29	R:R:N233	8.755	4	9	9
30	R:R:Y234	8.6725	4	1	7
31	R:R:F235	4.9875	4	13	5
32	R:R:W236	9.954	5	3	9
33	R:R:Y243	8.975	4	3	8
34	R:R:H245	12.695	4	0	8
35	R:R:P270	4.308	5	13	9
36	R:R:R281	9.02	4	7	7
37	R:R:F285	6.415	4	7	6
38	R:R:W290	10.96	5	0	9
39	R:R:T295	5.7725	4	7	4
40	R:R:H302	9.3325	4	1	6
41	R:R:M327	5.6	4	0	7
42	R:R:M337	4.18	4	0	7
43	R:R:L352	3.9075	4	0	9
44	R:R:Q355	7.1325	4	0	8
45	R:R:F356	8.09167	6	1	7
46	R:R:R362	7.92	4	0	4
47	R:R:Y372	7.69	4	10	7
48	R:R:Y374	5.0725	4	0	6
49	R:R:M376	5.4025	4	10	7
50	R:R:H377	6.9975	4	4	7
51	R:R:F385	8.6175	4	0	5
52	R:R:C392	4.985	4	12	9
53	R:R:F393	4.732	5	12	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:C1	R:R:H302	13.4812	13.27	Yes	Yes	1	0	6
2	R:R:H226	R:R:Q227	82.3292	4.95	No	Yes	0	6	7
3	R:R:H226	R:R:I198	82.1603	5.3	No	Yes	0	6	7
4	R:R:H156	R:R:I198	46.1101	11.93	Yes	Yes	0	7	7
5	R:R:H156	R:R:H381	38.9915	11.94	Yes	No	0	7	9
6	R:R:H377	R:R:H381	37.6609	9.55	Yes	No	0	7	9
7	L:L:M8	R:R:H377	18.2599	6.57	No	Yes	0	0	7
8	L:L:T6	R:R:H302	13.3309	6.85	Yes	Yes	1	0	6
9	L:L:T6	R:R:F356	10.8921	6.49	Yes	Yes	1	0	7
10	L:L:M8	R:R:M376	12.4987	4.33	No	Yes	0	0	7
11	L:L:Y12	R:R:H377	15.5595	5.44	Yes	Yes	4	0	7
12	L:L:F16	L:L:Y12	10.8159	9.28	Yes	Yes	4	0	0
13	L:L:C1	R:R:L298	15.2547	7.94	Yes	No	0	0	6
14	R:R:L298	R:R:T295	20.952	4.42	No	Yes	0	6	4
15	R:R:R281	R:R:T295	12.0538	6.47	Yes	Yes	7	7	4
16	R:R:D287	R:R:R281	88.5394	8.34	No	Yes	7	3	7
17	R:R:D287	R:R:S292	100	11.78	No	No	0	3	4
18	R:R:L40	R:R:S292	99.7652	4.5	No	No	0	5	4
19	L:L:F22	R:R:L40	99.5263	4.87	Yes	No	0	0	5
20	R:R:F285	R:R:T295	11.5656	7.78	Yes	Yes	7	6	4
21	R:R:D287	R:R:F285	11.6892	7.17	No	Yes	7	3	6
22	L:L:F22	L:L:T21	12.715	7.78	Yes	Yes	2	0	0
23	L:L:F22	R:R:P100	91.9174	13	Yes	No	2	0	4
24	R:R:F99	R:R:P100	91.868	4.33	No	No	0	5	4
25	L:L:T25	R:R:F99	64.9797	10.38	No	No	0	0	5
26	L:L:T25	R:R:D101	30.2354	5.78	No	No	0	0	4
27	L:L:Q24	R:R:D101	28.6947	10.44	No	No	0	0	4
28	L:L:Q24	R:R:N135	26.3528	3.96	No	No	0	0	3
29	L:L:T25	R:R:F102	44.7692	6.49	No	Yes	0	0	4
30	L:L:I27	R:R:N135	25.5639	14.16	No	No	0	0	3
31	R:R:F99	R:R:W79	30.1736	8.02	No	Yes	0	5	6
32	R:R:F102	R:R:Y131	28.4764	7.22	Yes	Yes	0	4	5
33	R:R:R281	R:R:W290	80.6649	16.99	Yes	Yes	0	7	9
34	R:R:W79	R:R:Y98	19.6626	4.82	Yes	Yes	0	6	4
35	R:R:F102	R:R:P96	14.6738	5.78	Yes	No	0	4	9
36	R:R:L80	R:R:P96	25.7183	11.49	No	No	0	5	9
37	R:R:L80	R:R:W82	36.8144	4.56	No	Yes	0	5	9
38	R:R:W118	R:R:W82	30.2581	4.69	Yes	Yes	5	9	9
39	R:R:T85	R:R:W118	29.1438	6.06	Yes	Yes	5	7	9
40	R:R:D83	R:R:T85	20.4721	1.45	No	Yes	0	5	7
41	R:R:D83	R:R:R74	17.5596	8.34	No	No	0	5	4
42	R:R:M59	R:R:R74	11.7222	3.72	No	No	0	5	4
43	R:R:P96	R:R:Y98	14.1568	5.56	No	Yes	0	9	4
44	R:R:L80	R:R:Y131	13.3	5.86	No	Yes	0	5	5
45	R:R:S129	R:R:Y131	14.2948	6.36	No	Yes	0	7	5
46	R:R:K110	R:R:S129	13.508	10.71	Yes	No	0	8	7
47	R:R:K110	R:R:W118	10.4657	10.44	Yes	Yes	5	8	9
48	L:L:I27	R:R:T132	24.7873	3.04	No	Yes	0	0	6
49	R:R:N130	R:R:T132	18.1652	10.24	Yes	Yes	8	8	6
50	R:R:N130	R:R:T109	15.7181	8.77	Yes	No	0	8	5
51	R:R:T109	R:R:Y92	14.8798	3.75	No	No	0	5	4
52	R:R:L90	R:R:Y92	13.1908	3.52	No	No	0	4	4
53	R:R:L90	R:R:Y111	12.3401	4.69	No	Yes	0	4	4
54	R:R:F356	R:R:Q355	11.3741	9.37	Yes	Yes	0	7	8
55	R:R:L163	R:R:Y191	35.3354	3.52	No	Yes	0	8	8
56	R:R:F188	R:R:L163	32.6083	4.87	No	No	0	8	8
57	R:R:F170	R:R:F188	31.9141	5.36	Yes	No	0	8	8
58	R:R:C392	R:R:F170	16.4329	5.59	Yes	Yes	0	9	8
59	R:R:C392	R:R:F393	13.2114	4.19	Yes	Yes	12	9	8
60	R:R:F170	R:R:L176	11.6769	4.87	Yes	Yes	0	8	9
61	R:R:M187	R:R:Y191	49.7065	7.18	No	Yes	0	8	8
62	R:R:E240	R:R:M187	49.1256	12.18	No	No	0	9	8
63	R:R:E240	R:R:L351	45.7806	9.28	No	No	0	9	9
64	R:R:L351	R:R:L352	43.5045	4.15	No	Yes	0	9	9
65	R:R:L352	R:R:N312	37.7948	5.49	Yes	No	0	9	9
66	R:R:L238	R:R:N312	37.1398	9.61	No	No	0	8	9
67	R:R:A308	R:R:L238	26.0994	4.73	No	No	0	7	8
68	R:R:A308	R:R:F235	25.3744	4.16	No	Yes	0	7	5
69	R:R:F235	R:R:P270	22.3753	5.78	Yes	Yes	13	5	9
70	R:R:C232	R:R:P270	17.127	7.53	No	Yes	0	8	9
71	R:R:C232	R:R:W267	14.7912	3.92	No	No	0	8	9
72	R:R:I198	R:R:N194	69.573	5.66	Yes	No	0	7	8
73	R:R:N233	R:R:Y191	66.5966	13.96	Yes	Yes	9	9	8
74	R:R:N194	R:R:N233	68.3701	9.54	No	Yes	0	8	9
75	R:R:H223	R:R:Q227	81.4641	8.65	No	Yes	0	5	7
76	R:R:I242	R:R:L238	12.4184	7.14	No	No	0	7	8
77	R:R:F315	R:R:I242	11.6192	3.77	No	No	0	8	7
78	R:R:F315	R:R:H245	10.0084	23.76	No	Yes	0	8	8
79	R:R:H223	R:R:W290	81.4146	10.58	No	Yes	0	5	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:C1	R:R:L298	7.94	1	Yes	No	0	6	0	1
L:L:C1	R:R:H302	13.27	1	Yes	Yes	0	6	0	1
L:L:N3	R:R:W361	15.82	0	No	No	0	4	0	1
L:L:N3	R:R:R362	4.82	0	No	Yes	0	4	0	1
L:L:S5	R:R:F356	6.61	0	No	Yes	0	7	0	1
L:L:T6	R:R:Y234	7.49	1	Yes	Yes	0	7	0	1
L:L:T6	R:R:H302	6.85	1	Yes	Yes	0	6	0	1
L:L:T6	R:R:V305	4.76	1	Yes	No	0	7	0	1
L:L:T6	R:R:M306	7.53	1	Yes	No	0	4	0	1
L:L:T6	R:R:F356	6.49	1	Yes	Yes	0	7	0	1
L:L:C7	R:R:H302	13.27	1	No	Yes	0	6	0	1
L:L:M8	R:R:D373	5.54	0	No	No	0	5	0	1
L:L:M8	R:R:M376	4.33	0	No	Yes	0	7	0	1
L:L:M8	R:R:H377	6.57	0	No	Yes	0	7	0	1
L:L:L9	R:R:I198	4.28	0	No	Yes	0	7	0	1
L:L:Y12	R:R:A145	4	4	Yes	No	0	4	0	1
L:L:Y12	R:R:L148	5.86	4	Yes	Yes	0	5	0	1
L:L:Y12	R:R:Y149	5.96	4	Yes	Yes	0	5	0	1
L:L:Y12	R:R:H377	5.44	4	Yes	Yes	0	7	0	1
L:L:T13	R:R:H201	5.48	0	No	Yes	0	6	0	1
L:L:Q14	R:R:V293	4.3	0	Yes	No	0	6	0	1
L:L:Q14	R:R:E294	6.37	0	Yes	No	0	3	0	1
L:L:F16	R:R:Y146	5.16	4	Yes	No	0	2	0	1
L:L:F16	R:R:Y149	10.32	4	Yes	Yes	0	5	0	1
L:L:F16	R:R:V206	5.24	4	Yes	No	0	3	0	1
L:L:N17	R:R:V212	7.39	2	No	No	0	3	0	1
L:L:N17	R:R:L291	4.12	2	No	No	0	6	0	1
L:L:F19	R:R:L142	9.74	0	No	No	0	2	0	1
L:L:T21	R:R:G209	5.46	2	Yes	No	0	3	0	1
L:L:T21	R:R:V212	4.76	2	Yes	No	0	3	0	1
L:L:F22	R:R:L40	4.87	2	Yes	No	0	5	0	1
L:L:F22	R:R:Y41	11.35	2	Yes	No	0	3	0	1
L:L:F22	R:R:P100	13	2	Yes	No	0	4	0	1
L:L:Q24	R:R:D101	10.44	0	No	No	0	4	0	1
L:L:Q24	R:R:N135	3.96	0	No	No	0	3	0	1
L:L:T25	R:R:F99	10.38	0	No	No	0	5	0	1
L:L:T25	R:R:D101	5.78	0	No	No	0	4	0	1
L:L:T25	R:R:F102	6.49	0	No	Yes	0	4	0	1
L:L:I27	R:R:N135	14.16	0	No	No	0	3	0	1
L:L:P32	R:R:G78	4.06	6	No	No	0	5	0	1
L:L:P32	R:R:W79	4.05	6	No	Yes	0	6	0	1
L:L:?33	R:R:G78	4.23	6	No	No	0	5	0	1
L:L:?33	R:R:Y131	11.61	6	No	Yes	0	5	0	1
R:R:L40	R:R:S292	4.5	0	No	No	5	4	1	2
R:R:P100	R:R:Y41	8.34	2	No	No	4	3	1	1
R:R:M48	R:R:W79	4.65	0	No	Yes	6	6	2	1
R:R:G78	R:R:W79	5.63	6	No	Yes	5	6	1	1
R:R:W79	R:R:Y98	4.82	6	Yes	Yes	6	4	1	2
R:R:F99	R:R:W79	8.02	0	No	Yes	5	6	1	1
R:R:L80	R:R:P96	11.49	0	No	No	5	9	2	2
R:R:L80	R:R:Y131	5.86	0	No	Yes	5	5	2	1
R:R:P96	R:R:Y98	5.56	0	No	Yes	9	4	2	2
R:R:F102	R:R:P96	5.78	0	Yes	No	4	9	1	2
R:R:F99	R:R:P100	4.33	0	No	No	5	4	1	1
R:R:F102	R:R:Y131	7.22	0	Yes	Yes	4	5	1	1
R:R:C134	R:R:F102	11.17	0	No	Yes	9	4	2	1
R:R:V108	R:R:Y131	5.05	0	No	Yes	7	5	2	1
R:R:H121	R:R:N124	20.41	0	No	No	4	5	2	1
R:R:N124	R:R:R126	7.23	0	No	No	5	4	1	2
R:R:N130	R:R:W128	7.91	8	Yes	No	8	5	2	1
H:H:?1	R:R:W128	4.09	8	No	No	0	5	2	1
R:R:S129	R:R:Y131	6.36	0	No	Yes	7	5	2	1
R:R:N130	R:R:T132	10.24	8	Yes	Yes	8	6	2	1
H:H:?1	R:R:N130	25.87	8	No	Yes	0	8	2	2
R:R:M133	R:R:T132	4.52	0	No	Yes	5	6	2	1
H:H:?1	R:R:T132	17.19	8	No	Yes	0	6	2	1
R:R:L142	R:R:Y146	7.03	0	No	No	2	2	1	1
R:R:Y146	R:R:Y150	3.97	0	No	No	2	4	1	2
R:R:H377	R:R:L148	6.43	4	Yes	Yes	7	5	1	1
R:R:Y149	R:R:Y150	3.97	4	Yes	No	5	4	1	2
R:R:I153	R:R:Y149	4.84	0	No	Yes	7	5	2	1
R:R:L202	R:R:Y149	4.69	0	No	Yes	7	5	2	1
R:R:P207	R:R:Y149	6.95	0	No	Yes	3	5	2	1
R:R:H156	R:R:I198	11.93	0	Yes	Yes	7	7	2	1
R:R:H156	R:R:H381	11.94	0	Yes	No	7	9	2	2
R:R:I198	R:R:N194	5.66	0	Yes	No	7	8	1	2
R:R:H226	R:R:I198	5.3	0	No	Yes	6	7	2	1
R:R:H201	R:R:V205	12.45	0	Yes	No	6	7	1	2
R:R:H201	R:R:V206	5.54	0	Yes	No	6	3	1	1
R:R:P207	R:R:V206	5.3	0	No	No	3	3	2	1
R:R:E210	R:R:R213	4.65	0	No	No	3	2	2	1
R:R:C289	R:R:V212	5.12	0	No	No	9	3	2	1
R:R:M230	R:R:Y234	5.99	0	No	Yes	6	7	2	1
R:R:H302	R:R:M230	3.94	1	Yes	No	6	6	1	2
R:R:V305	R:R:Y234	8.83	1	No	Yes	7	7	1	1
R:R:F356	R:R:Y234	12.38	1	Yes	Yes	7	7	1	1
R:R:H277	R:R:L298	10.29	0	No	No	7	6	2	1
R:R:C289	R:R:L291	4.76	0	No	No	9	6	2	1
R:R:L298	R:R:T295	4.42	0	No	Yes	6	4	1	2
R:R:F356	R:R:Q355	9.37	1	Yes	Yes	7	8	1	2
R:R:F356	R:R:I380	10.05	1	Yes	No	7	6	1	2
R:R:F359	R:R:Y372	5.16	10	No	Yes	6	7	2	2
R:R:F359	R:R:M376	4.98	10	No	Yes	6	7	2	1
R:R:G369	R:R:R362	4.5	0	No	Yes	4	4	2	1
R:R:R362	R:R:Y372	9.26	0	Yes	Yes	4	7	1	2
R:R:D373	R:R:R362	13.1	0	No	Yes	5	4	1	1
R:R:M376	R:R:Y372	10.78	10	Yes	Yes	7	7	1	2
R:R:H377	R:R:H381	9.55	4	Yes	No	7	9	1	2
L:L:T21	R:R:R213	3.88	2	Yes	No	0	2	0	1
R:R:H201	R:R:L222	3.86	0	Yes	No	6	6	1	2
R:R:F356	R:R:L309	3.65	1	Yes	No	7	7	1	2
R:R:L148	R:R:Y374	3.52	4	Yes	Yes	5	6	1	2
R:R:P139	R:R:T138	3.5	0	No	No	3	2	2	1
L:L:L4	R:R:W361	3.42	0	No	No	0	4	0	1
L:L:I27	R:R:T132	3.04	0	No	Yes	0	6	0	1
L:L:V29	R:R:N124	2.96	0	No	No	0	5	0	1
L:L:Q24	R:R:T138	2.83	0	No	No	0	2	0	1
L:L:C1	R:R:Y299	2.69	1	Yes	No	0	7	0	1
L:L:A31	R:R:W128	2.59	0	No	No	0	5	0	1
R:R:H296	R:R:Y299	2.18	0	No	No	2	7	2	1
L:L:G2	R:R:V293	1.84	0	No	No	0	6	0	1
L:L:G10	R:R:V293	1.84	0	No	No	0	6	0	1
R:R:M306	R:R:P360	1.68	0	No	No	4	5	1	2
R:R:A136	R:R:D101	1.54	0	No	No	2	4	2	1
R:R:M376	R:R:V375	1.52	10	Yes	No	7	4	1	2
R:R:L148	R:R:L151	1.38	4	Yes	No	5	5	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7TYO_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.92
Number of Linked Nodes	367
Number of Links	403
Number of Hubs	53
Number of Links mediated by Hubs	199
Number of Communities	13
Number of Nodes involved in Communities	57
Number of Links involved in Communities	67

Path Summary
Number Of Nodes in MetaPath	80
Number Of Links MetaPath	79
Number of Shortest Paths	89685
Length Of Smallest Path	3
Average Path Length	19.4229
Length of Longest Path	48
Minimum Path Strength	1.175
Average Path Strength	7.45166
Maximum Path Strength	19.52
Minimum Path Correlation	0.7
Average Path Correlation	0.957354
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	2.77778
Average % Of Corr. Nodes	54.7864
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	40.0331
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• amyloid-beta binding • binding • peptide binding • calcitonin family receptor activity • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • calcitonin receptor activity • amylin receptor activity • calcitonin gene-related peptide receptor activity • calcitonin binding • calcitonin family binding • peptide hormone binding • hormone binding • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • cellular response to stimulus • positive regulation of cell communication • regulation of cellular process • positive regulation of signal transduction • response to stimulus • signaling • positive regulation of biological process • regulation of signal transduction • intracellular signal transduction • cell communication • positive regulation of response to stimulus
Gene Ontology	Biological Process	• positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • cellular response to stimulus • positive regulation of cell communication • regulation of cellular process • positive regulation of signal transduction • response to stimulus • signaling • positive regulation of biological process • regulation of signal transduction • intracellular signal transduction • cell communication • positive regulation of response to stimulus • regulation of intracellular signal transduction • intracellular signaling cassette • regulation of calcium-mediated signaling • positive regulation of calcium-mediated signaling • signal transduction • positive regulation of cellular process • regulation of biological process • regulation of signaling • positive regulation of intracellular signal transduction • regulation of response to stimulus • calcium-mediated signaling • regulation of cell communication • cellular process • positive regulation of signaling • catabolic process • negative regulation of biological process • RNA metabolic process • macromolecule catabolic process • regulation of primary metabolic process • nucleobase-containing compound metabolic process • post-transcriptional regulation of gene expression • regulation of RNA metabolic process • regulation of mRNA catabolic process • negative regulation of cellular process • regulation of nucleobase-containing compound metabolic process • RNA catabolic process • negative regulation of macromolecule metabolic process • regulation of biosynthetic process • mRNA catabolic process • negative regulation of metabolic process • primary metabolic process • regulation of macromolecule metabolic process • regulation of catabolic process • gene expression • mRNA metabolic process • macromolecule biosynthetic process • nucleic acid metabolic process • nucleobase-containing compound catabolic process • regulation of mRNA stability • regulation of gene expression • negative regulation of gene expression • biosynthetic process • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • regulation of RNA stability • nucleic acid catabolic process • metabolic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • regulation of mRNA metabolic process • regulation of metabolic process • positive regulation of ERK1 and ERK2 cascade • positive regulation of MAPK cascade • regulation of MAPK cascade • MAPK cascade • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of macromolecule biosynthetic process • positive regulation of metabolic process • positive regulation of gene expression • positive regulation of biosynthetic process • positive regulation of macromolecule metabolic process • amylin receptor 1 signaling pathway • amylin receptor signaling pathway • calcitonin family receptor signaling pathway • G protein-coupled receptor signaling pathway • regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • phosphatidylinositol 3-kinase/protein kinase B signal transduction • response to corticosteroid • response to lipid • response to hormone • response to steroid hormone • response to chemical • response to endogenous stimulus • response to glucocorticoid • adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • response to amyloid-beta • cell surface receptor signaling pathway • calcitonin gene-related peptide receptor signaling pathway • multicellular organismal process • ossification • amylin receptor 2 signaling pathway • developmental process • myeloid leukocyte differentiation • cellular developmental process • hemopoiesis • cell development • myeloid cell differentiation • cell differentiation • osteoclast differentiation • anatomical structure development • leukocyte differentiation • positive regulation of cAMP/PKA signal transduction • cAMP/PKA signal transduction • regulation of cAMP/PKA signal transduction • regulation of multicellular organismal process • negative regulation of multicellular organismal process • regulation of ossification • negative regulation of ossification • amylin receptor 3 signaling pathway • membrane-bounded organelle • cell projection • cellular anatomical structure • organelle • cilium • plasma membrane bounded cell projection • cell periphery • plasma membrane • membrane • protein-containing complex • amylin receptor complex • plasma membrane protein complex • amylin receptor complex 3 • membrane protein complex
Gene Ontology	Cellular Component	• membrane-bounded organelle • cell projection • cellular anatomical structure • organelle • cilium • plasma membrane bounded cell projection • cell periphery • plasma membrane • membrane • protein-containing complex • amylin receptor complex • plasma membrane protein complex • amylin receptor complex 3 • membrane protein complex • receptor complex • plasma membrane signaling receptor complex • G protein-coupled receptor complex • calcitonin family receptor complex • amylin receptor complex 2 • amylin receptor complex 1 • axon • neuron projection • acrosomal vesicle • intracellular anatomical structure • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle • secretory granule • secretory vesicle • cytoplasm • vesicle • hormone activity • molecular function activator activity • molecular function regulator activity • signaling receptor regulator activity • receptor ligand activity • signaling receptor activator activity • calcitonin receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • identical protein binding • regulation of cellular process • negative regulation of biological process • RNA metabolic process • regulation of primary metabolic process • negative regulation of RNA biosynthetic process • RNA biosynthetic process • nucleobase-containing compound metabolic process • DNA-templated transcription • nucleic acid biosynthetic process • regulation of RNA metabolic process • negative regulation of cellular process • negative regulation of nucleobase-containing compound metabolic process • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • negative regulation of macromolecule metabolic process • regulation of biosynthetic process • negative regulation of DNA-templated transcription • regulation of biological process • negative regulation of metabolic process • biological regulation • primary metabolic process • regulation of macromolecule metabolic process • nucleobase-containing compound biosynthetic process • gene expression • macromolecule biosynthetic process • nucleic acid metabolic process • regulation of gene expression • biosynthetic process • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • metabolic process • cellular process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • regulation of DNA-templated transcription • regulation of metabolic process • negative regulation of RNA metabolic process • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • inorganic ion homeostasis • intracellular calcium ion homeostasis • homeostatic process • calcium ion homeostasis • regulation of cytosolic calcium ion concentration • cellular homeostasis • chemical homeostasis • intracellular monoatomic cation homeostasis • monoatomic ion homeostasis • intracellular chemical homeostasis • monoatomic cation homeostasis • intracellular monoatomic ion homeostasis • cellular response to endogenous stimulus • cellular response to growth factor stimulus • response to stimulus • response to endogenous stimulus • cellular response to nerve growth factor stimulus • response to nerve growth factor • response to growth factor • regulation of protein modification process • positive regulation of phosphorylation • regulation of catalytic activity • regulation of protein phosphorylation • positive regulation of protein metabolic process • positive regulation of biological process • regulation of transferase activity • positive regulation of phosphate metabolic process • positive regulation of metabolic process • positive regulation of molecular function • positive regulation of protein modification process • phosphate-containing compound metabolic process • positive regulation of macromolecule metabolic process • protein metabolic process • positive regulation of protein kinase activity • phosphorus metabolic process • protein modification process • positive regulation of protein phosphorylation • positive regulation of cellular process • protein phosphorylation • positive regulation of phosphorus metabolic process • phosphorylation • regulation of protein metabolic process • positive regulation of catalytic activity • regulation of protein kinase activity • regulation of molecular function • positive regulation of kinase activity • regulation of kinase activity • activation of protein kinase activity • macromolecule modification • regulation of phosphorylation • regulation of phosphorus metabolic process • developmental process • multicellular organism development • multicellular organismal process • multi-multicellular organism process • reproductive process • anatomical structure development • female pregnancy • embryo implantation • multi-organism reproductive process • cellular response to stimulus • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • regulation of tube diameter • system process • regulation of tube size • circulatory system process • vascular process in circulatory system • blood vessel diameter maintenance • vasodilation • blood circulation • regulation of anatomical structure size • response to peptide • cellular response to tumor necrosis factor • response to chemical • response to cytokine • cellular response to cytokine stimulus • response to tumor necrosis factor • negative regulation of tissue remodeling • negative regulation of bone remodeling • regulation of bone remodeling • tissue homeostasis • regulation of tissue remodeling • regulation of bone resorption • bone resorption • negative regulation of bone resorption • multicellular organismal-level homeostasis • tissue remodeling • bone remodeling • anatomical structure homeostasis • regulation of multicellular organismal process • negative regulation of multicellular organismal process • calcitonin family receptor signaling pathway • cell chemotaxis • chemotaxis • response to external stimulus • monocyte chemotaxis • leukocyte migration • cellular response to chemical stimulus • taxis • immune system process • mononuclear cell migration • myeloid leukocyte migration • cell migration • cell motility • leukocyte chemotaxis • locomotion • amylin receptor signaling pathway • amylin receptor 2 signaling pathway • regulation of system process • muscle contraction • muscle system process • regulation of muscle system process • negative regulation of muscle contraction • smooth muscle contraction • regulation of smooth muscle contraction • regulation of muscle contraction • negative regulation of smooth muscle contraction • regulation of blood pressure • negative regulation of blood pressure • dense core granule • neuronal dense core vesicle • neuron to neuron synapse • synapse • cell junction • hippocampal mossy fiber to CA3 synapse • extracellular region • somatodendritic compartment • cell body • neuronal cell body • extracellular space • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to monoamine stimulus • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • extrinsic component of plasma membrane • catalytic complex • cytoplasmic side of membrane • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular membrane-bounded organelle • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • organelle membrane • cytosol • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • dopamine receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • glucose homeostasis • carbohydrate homeostasis • intracellular glucose homeostasis • neuromuscular process • skeletal muscle contraction • striated muscle contraction • multicellular organismal movement • musculoskeletal movement • regulation of striated muscle contraction • regulation of skeletal muscle contraction • sensory perception of smell • response to peptide hormone • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • skeletal system development • bone development • response to pH • cellular response to pH • response to abiotic stimulus • cellular response to acidic pH • response to acidic pH • cellular response to abiotic stimulus • cellular response to environmental stimulus • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • adaptive thermogenesis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • positive regulation of cell communication • regulation of localization • establishment of protein localization • nitrogen compound transport • positive regulation of establishment of protein localization • localization • establishment of localization in cell • positive regulation of insulin secretion involved in cellular response to glucose stimulus • positive regulation of insulin secretion • intracellular protein localization • regulation of peptide hormone secretion • regulation of hormone levels • positive regulation of peptide hormone secretion • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • cellular response to carbohydrate stimulus • response to glucose • positive regulation of protein localization • insulin secretion involved in cellular response to glucose stimulus • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • positive regulation of secretion by cell • hormone secretion • protein localization to extracellular region • positive regulation of protein transport • peptide secretion • regulation of secretion by cell • secretion by cell • positive regulation of hormone secretion • response to monosaccharide • response to carbohydrate • positive regulation of secretion • signal release • cellular response to hexose stimulus • cellular response to monosaccharide stimulus • positive regulation of peptide secretion • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cellular response to glucose stimulus • regulation of protein transport • positive regulation of protein secretion • peptide transport • response to hexose • positive regulation of transport • regulation of cellular localization • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • regulation of insulin secretion involved in cellular response to glucose stimulus • hormone transport • regulation of cell communication • insulin secretion • positive regulation of signaling • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • serotonin receptor signaling pathway • adenylate cyclase-activating serotonin receptor signaling pathway • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • positive regulation of lyase activity • cell surface receptor signaling pathway • bile acid signaling pathway • adenylate cyclase-activating G protein-coupled bile acid receptor signaling pathway • renal system process • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • trans-Golgi network
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	NH2
PDB Residues	L:L:?33
Environment Details	Open EMBL-EBI Page
Code	NH2
Name	AMINO GROUP
Synonyms
Identifier
Formula	H2 N
Molecular Weight	16.023
SMILES
PubChem	123329
Formal Charge	0
Total Atoms	3
Total Chiral Atoms	0
Total Bonds	2
Total Aromatic Bonds	0


Code	NAG
PDB Residues	H:H:?1
Environment Details	Open EMBL-EBI Page
Code	NAG
Name	N-Acetylglucosamine
Synonyms	N-Acetylchitosamine
Identifier
Formula	C8 H15 N O6
Molecular Weight	221.208
SMILES
PubChem	24139
Formal Charge	0
Total Atoms	30
Total Chiral Atoms	5
Total Bonds	30
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	L
Protein	Calcitonin
UniProt	P01258
Sequence	>7TYO_nogp_Chain_L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	R
Protein	Receptor
UniProt	P30988
Sequence	>7TYO_nogp_Chain_R P F L Y V V G R K K M M D A Q Y K C Y D R M Q Y C N R T W D G W L C W D D T P A G V L S Y Q F C P D Y F P D F D P S E K V T K Y C D V W F K H P E N N R T W S N Y T M C N A F T P E K L K N A Y V L Y Y L A I V G H S L S I F T L V I S L G I F V F F R S L G C Q R V T L H K N M F L T Y I L N S M I I I I H L V E V V P N G E L V R R D P V S C K I L H F F H Q Y M M A C N Y F W M L C E G I Y L H T L I V V A V F T E K Q R L R W Y Y L L G W G F P L V P T T I H A I T R A V Y F N D N C W L S V E T H L L Y I I H G P V M A A L V V N F F F L L N I V R V L V T K M R E T H E A E S H M Y L K A V K A T M I L V P L L G I Q F V V F P W R P S N K M L G K I Y D Y V M H S L I H F Q G F F V A T I Y C F C N N E V Q T T V K R Q W A Q F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	3DQB	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	Gt(CT)	3.2	2008-09-23	doi.org/10.1038/nature07330
	3PQR	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gt(CT)	2.85	2011-03-09	doi.org/10.1038/nature09789
	2X72	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gt(CT)	3	2011-03-16	doi.org/10.1038/nature09795
	4A4M	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gt(CT)	3.3	2012-01-25	doi.org/10.1073/pnas.1114089108
	4BEY	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	Gt(CT)	2.9	2013-05-08	doi.org/10.1038/embor.2013.44
	4J4Q	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl β-D-Glucopyranoside	-	Gt(CT)	2.65	2013-10-30	doi.org/10.1002/anie.201302374
	4X1H	A	Sensory	Opsins	Rhodopsin	Bos taurus	Nonyl-β-D-Glucopyranoside	-	Gt(CT)	2.29	2015-11-04	doi.org/10.1016/j.str.2015.09.015
	5EN0	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gt(CT)	2.81	2016-08-10	doi.org/10.15252/embr.201642671
	5UZ7	B1	Peptide	Calcitonin	CT	Homo sapiens	-	-	Gs/β1/γ2	4.1	2017-05-03	doi.org/10.1038/nature22327
	5UZ7 (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	-	-		4.1	2017-05-03	doi.org/10.1038/nature22327
	5WKT	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl-β-D-Glucopyranoside	-	Gt(CT)	3.2	2017-12-13	doi.org/10.1038/nprot.2017.135
	6E3Y	B1	Peptide	Calcitonin	CT Like	Homo sapiens	Calcitonin gene-related peptide-1	-	Gs/β1/γ2; RAMP1	3.3	2018-09-19	doi.org/10.1038/s41586-018-0535-y
	6E3Y (No Gprot)	B1	Peptide	Calcitonin	CT Like	Homo sapiens	Calcitonin gene-related peptide-1	-		3.3	2018-09-19	doi.org/10.1038/s41586-018-0535-y
	6NIY	B1	Peptide	Calcitonin	CT	Homo sapiens	Calcitonin-1	-	Gs/β1/γ2	3.34	2019-01-23	doi.org/10.1021/acsptsci.8b00056
	6NIY (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	Calcitonin-1	-		3.34	2019-01-23	doi.org/10.1021/acsptsci.8b00056
	6E67	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	-	Gs(CT)	3.7	2019-06-05	doi.org/10.1016/j.cell.2019.04.021
	6TP4	A	Peptide	Orexin	OX₁	Homo sapiens	ACT-462206	-	-	3.01	2020-01-01	doi.org/10.1021/acs.jmedchem.9b01787
	6NWE	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl-β-D-Glucopyranoside	-	Gt(CT)	2.71	2020-02-12	To be published
	6UUN	B1	Peptide	Calcitonin	CT Like (AM1)	Homo sapiens	Adrenomedullin	-	Gs/β1/γ2; RAMP2	3	2020-03-25	doi.org/10.1021/acsptsci.9b00080
	6UUN (No Gprot)	B1	Peptide	Calcitonin	CT Like (AM1)	Homo sapiens	Adrenomedullin	-		3	2020-03-25	doi.org/10.1021/acsptsci.9b00080
	6UUS	B1	Peptide	Calcitonin	CT Like (AM2)	Homo sapiens	Adrenomedullin	-	Gs/β1/γ2; RAMP3	2.4	2020-04-01	doi.org/10.1021/acsptsci.9b00080
	6UUS (No Gprot)	B1	Peptide	Calcitonin	CT Like (AM2)	Homo sapiens	Adrenomedullin	-		2.4	2020-04-01	doi.org/10.1021/acsptsci.9b00080
	6UVA	B1	Peptide	Calcitonin	CT Like (AM2)	Homo sapiens	Adrenomedullin-2	-	Gs/β1/γ2; RAMP3	2.3	2020-04-01	doi.org/10.1021/acsptsci.9b00080
	6UVA (No Gprot)	B1	Peptide	Calcitonin	CT Like (AM2)	Homo sapiens	Adrenomedullin-2	-		2.3	2020-04-01	doi.org/10.1021/acsptsci.9b00080
	6PEL	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	Citronellol	Gt(CT)	3.19	2020-06-24	To be published
	6PGS	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	Geraniol	Gt(CT)	2.9	2020-07-01	To be published
	6PH7	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	Nerol	Gt(CT)	2.9	2020-07-01	To be published
	7KNT	B1	Peptide	Calcitonin	CT Like	Homo sapiens	-	-	RAMP1	3.15	2021-02-24	doi.org/10.1126/science.abf7258
	7KNU	B1	Peptide	Calcitonin	CT Like	Homo sapiens	Calcitonin gene-related peptide-1	-	RAMP1	3.49	2021-02-24	doi.org/10.1126/science.abf7258
	7TYL	B1	Peptide	Calcitonin	CT	Homo sapiens	Amylin	-	Gs/β1/γ2	3.3	2022-03-23	doi.org/10.1126/science.abm9609
	7TYL (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	Amylin	-		3.3	2022-03-23	doi.org/10.1126/science.abm9609
	7TYO	B1	Peptide	Calcitonin	CT	Homo sapiens	Calcitonin	-	Gs/β1/γ2	2.7	2022-03-23	doi.org/10.1126/science.abm9609
	7TYO (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	Calcitonin	-		2.7	2022-03-23	doi.org/10.1126/science.abm9609
	7TYF	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Amylin	-	Gs/β1/γ2; RAMP1	2.2	2022-03-23	doi.org/10.1126/science.abm9609
	7TYF (No Gprot)	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Amylin	-		2.2	2022-03-23	doi.org/10.1126/science.abm9609
	7TYW	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Calcitonin-1	-	Gs/β1/γ2; RAMP1	3	2022-03-23	doi.org/10.1126/science.abm9609
	7TYW (No Gprot)	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Calcitonin-1	-		3	2022-03-23	doi.org/10.1126/science.abm9609
	7TYH	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Calcitonin	-	Gs/β1/γ2; RAMP2	3.3	2022-03-23	doi.org/10.1126/science.abm9609
	7TYH (No Gprot)	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Calcitonin	-		3.3	2022-03-23	doi.org/10.1126/science.abm9609
	7TYY	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Calcitonin-1	-	Gs/β1/γ2; RAMP2	3	2022-03-23	doi.org/10.1126/science.abm9609
	7TYY (No Gprot)	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Calcitonin-1	-		3	2022-03-23	doi.org/10.1126/science.abm9609
	7TZF	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Amylin	-	Gs/β1/γ2; RAMP3	2.4	2022-03-23	doi.org/10.1126/science.abm9609
	7TZF (No Gprot)	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Amylin	-		2.4	2022-03-23	doi.org/10.1126/science.abm9609
	7TYI	B1	Peptide	Calcitonin	CT	Homo sapiens	Amylin	-	Gs/β1/γ2	3.3	2022-03-30	doi.org/10.1126/science.abm9609
	7TYI (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	Amylin	-		3.3	2022-03-30	doi.org/10.1126/science.abm9609
	7TYN	B1	Peptide	Calcitonin	CT	Homo sapiens	Calcitonin-1	-	Gs/β1/γ2	2.6	2022-03-30	doi.org/10.1126/science.abm9609
	7TYN (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	Calcitonin-1	-		2.6	2022-03-30	doi.org/10.1126/science.abm9609
	7TYX	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Amylin	-	Gs/β1/γ2; RAMP2	2.55	2022-03-30	doi.org/10.1126/science.abm9609
	7TYX (No Gprot)	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Amylin	-		2.55	2022-03-30	doi.org/10.1126/science.abm9609
	7UM5	A	Amine	5-Hydroxytryptamine	5-HT_5A	Homo sapiens	5-CT	-	chim(NtGi1-Go)/β1/γ2	2.73	2022-07-20	doi.org/10.1038/s41594-022-00796-6
	7UM5 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_5A	Homo sapiens	5-CT	-		2.73	2022-07-20	doi.org/10.1038/s41594-022-00796-6
	7XTC	A	Amine	5-Hydroxytryptamine	5-HT₇	Homo sapiens	5-CT	-	Gs/β1/γ2	3.2	2022-07-27	doi.org/10.1016/j.molcel.2022.05.031
	7XTC (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT₇	Homo sapiens	5-CT	-		3.2	2022-07-27	doi.org/10.1016/j.molcel.2022.05.031
	7X5H	A	Amine	5-Hydroxytryptamine	5-HT_5A	Homo sapiens	5-CT	-	Gi1/β1/γ2	3.1	2022-09-14	doi.org/10.1038/s41421-022-00412-3
	7X5H (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_5A	Homo sapiens	5-CT	-		3.1	2022-09-14	doi.org/10.1038/s41421-022-00412-3
	8F0J	B1	Peptide	Calcitonin	CT	Homo sapiens	Pramlintide Analogue San45	-	Gs/β1/γ2	2	2023-08-02	doi.org/10.1038/s41589-023-01393-4
	8F0J (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	Pramlintide Analogue San45	-		2	2023-08-02	doi.org/10.1038/s41589-023-01393-4
	8F0K	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Pramlintide Analogue San385	-	Gs/β1/γ2; RAMP3	1.9	2023-08-02	doi.org/10.1038/s41589-023-01393-4
	8F0K (No Gprot)	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Pramlintide Analogue San385	-		1.9	2023-08-02	doi.org/10.1038/s41589-023-01393-4
	8F2A	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Pramlintide Analogue San385	-	Gs/β1/γ2; RAMP3	2.2	2023-08-02	doi.org/10.1038/s41589-023-01393-4
	8F2A (No Gprot)	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Pramlintide Analogue San385	-		2.2	2023-08-02	doi.org/10.1038/s41589-023-01393-4
	8F2B	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Pramlintide Analogue San45	-	Gs/β1/γ2; RAMP3	2	2023-08-02	doi.org/10.1038/s41589-023-01393-4
	8F2B (No Gprot)	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Pramlintide Analogue San45	-		2	2023-08-02	doi.org/10.1038/s41589-023-01393-4
	8ZQE	A	Orphan	Orphan	GPR15	Homo sapiens	GPR15L(CT)	-	Gi1/β1/γ1	2.9	2024-07-10	doi.org/10.1038/s41421-024-00698-5
	8ZQE (No Gprot)	A	Orphan	Orphan	GPR15	Homo sapiens	GPR15L(CT)	-		2.9	2024-07-10	doi.org/10.1038/s41421-024-00698-5
	9MNI	B1	Peptide	Calcitonin	CTLike	Homo sapiens	dC2_05	-	RAMP1	4.06	2025-10-22	doi.org/10.1101/2025.03.23.644666
	9AUC	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Calcitonin gene-related peptide-1	-	Gs/β1/γ2; RAMP1	2.4	2024-04-24	doi.org/10.1021/acs.biochem.4c00114
	9AUC (No Gprot)	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Calcitonin gene-related peptide-1	-		2.4	2024-04-24	doi.org/10.1021/acs.biochem.4c00114
	9BLB	B1	Peptide	Calcitonin	CT	Homo sapiens	Cagrilintide (non-acylated)	-	Gs/β1/γ2	3.2	2025-04-16	doi.org/10.1038/s41467-025-58680-y
	9BLB (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	Cagrilintide (non-acylated)	-		3.2	2025-04-16	doi.org/10.1038/s41467-025-58680-y
	9BLC	B1	Peptide	Calcitonin	CT	Homo sapiens	Cagrilintide (non-acylated)	-	Gs/β1/γ2	3.3	2025-04-16	doi.org/10.1038/s41467-025-58680-y
	9BLC (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	Cagrilintide (non-acylated)	-		3.3	2025-04-16	doi.org/10.1038/s41467-025-58680-y
	9BUE	B1	Peptide	Calcitonin	CT	Homo sapiens	Cagrilintide	-	Gs/β1/γ2	3.6	2025-04-16	doi.org/10.1038/s41467-025-58680-y
	9BUE (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	Cagrilintide	-		3.6	2025-04-16	doi.org/10.1038/s41467-025-58680-y
	9BLW	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Cagrilintide (non-acylated)	-	Gs/β1/γ2; RAMP1	3.2	2025-04-16	doi.org/10.1038/s41467-025-58680-y
	9BLW (No Gprot)	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Cagrilintide (non-acylated)	-		3.2	2025-04-16	doi.org/10.1038/s41467-025-58680-y
	9BTW	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Cagrilintide	-	Gs/β1/γ2; RAMP3	3	2025-04-16	To be published
	9BTW (No Gprot)	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Cagrilintide	-		3	2025-04-16	To be published
	9BUB	B1	Peptide	Calcitonin	CT	Homo sapiens	Cagrilintide	-	Gs/β1/γ2	2.3	2025-04-23	doi.org/10.1038/s41467-025-58680-y
	9BUB (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	Cagrilintide	-		2.3	2025-04-23	doi.org/10.1038/s41467-025-58680-y
	9BUC	B1	Peptide	Calcitonin	CT	Homo sapiens	Cagrilintide	-	Gs/β1/γ2	3.4	2025-04-23	doi.org/10.1038/s41467-025-58680-y
	9BUC (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	Cagrilintide	-		3.4	2025-04-23	doi.org/10.1038/s41467-025-58680-y
	9BUD	B1	Peptide	Calcitonin	CT	Homo sapiens	Cagrilintide	-	Gs/β1/γ2	2.5	2025-04-23	doi.org/10.1038/s41467-025-58680-y
	9BUD (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	Cagrilintide	-		2.5	2025-04-23	doi.org/10.1038/s41467-025-58680-y
	9BP3	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Cagrilintide	-	Gs/β1/γ2; RAMP1	2.2	2025-04-23	doi.org/10.1038/s41467-025-58680-y
	9BP3 (No Gprot)	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Cagrilintide	-		2.2	2025-04-23	doi.org/10.1038/s41467-025-58680-y
	9BQ3	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Cagrilintide	-	Gs/β1/γ2; RAMP2	2.8	2025-04-23	doi.org/10.1038/s41467-025-58680-y
	9BQ3 (No Gprot)	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Cagrilintide	-		2.8	2025-04-23	doi.org/10.1038/s41467-025-58680-y
	9UAP	A	Amine	Acetylcholine (muscarinic)	M₁	Homo sapiens	-	-	G11(CT)	3.62	2025-10-29	To be published
	9UCP	A	Amine	Acetylcholine (muscarinic)	M₁	Homo sapiens	Iperoxo	-	G11(CT)	2.88	2025-10-29	To be published
	9WXM	A	Orphan	Orphan	GPR15	Homo sapiens	GPR15L(CT)	-	Gi3/β1/γ2	3.3	2025-11-19	10.1016/j.isci.2025.113935
	9WXM (No Gprot)	A	Orphan	Orphan	GPR15	Homo sapiens	GPR15L(CT)	-		3.3	2025-11-19	10.1016/j.isci.2025.113935
	9W6W	A	Amine	5-Hydroxytryptamine	5-HT_5A	Homo sapiens	5-CT	-	Gi1/β1/γ2	3.13	2025-11-26	10.1186/s43556-025-00359-3
	9W6W (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_5A	Homo sapiens	5-CT	-		3.13	2025-11-26	10.1186/s43556-025-00359-3

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7TYO_nogp.zip

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You can also read or download a guide explaining the meaning of all files and numerical data.