psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I84	R:R:V82	7.68	No	No	0	4	6
2	R:R:I84	R:R:L143	8.56	No	No	0	4	4
3	R:R:L88	R:R:S139	7.51	No	Yes	5	6	6
4	R:R:L143	R:R:L88	6.92	No	No	0	4	6
5	R:R:L88	R:R:W371	14.81	No	No	5	6	6
6	R:R:L90	R:R:L94	6.92	No	No	0	4	4
7	R:R:P136	R:R:T92	3.5	No	No	0	8	6
8	R:R:N99	R:R:T95	4.39	Yes	Yes	0	9	8
9	R:R:A131	R:R:T95	3.36	No	Yes	0	7	8
10	R:R:M135	R:R:T95	4.52	No	Yes	0	8	8
11	R:R:L378	R:R:T95	7.37	No	Yes	0	7	8
12	R:R:D127	R:R:N99	8.08	Yes	Yes	0	9	9
13	R:R:L128	R:R:N99	6.87	No	Yes	0	8	9
14	R:R:C100	R:R:L128	4.76	No	No	0	4	8
15	R:R:A124	R:R:V102	3.39	No	No	0	9	9
16	R:R:F108	R:R:I104	7.54	No	No	0	4	5
17	R:R:S105	R:R:Y395	6.36	No	Yes	0	8	7
18	R:R:V106	R:R:V121	4.81	No	No	0	8	5
19	R:R:K111	R:R:V109	4.55	No	No	0	5	6
20	R:R:L112	R:R:V109	7.45	Yes	No	0	8	6
21	R:R:K110	R:R:R113	8.66	No	No	0	6	8
22	R:R:K111	R:R:T394	7.51	No	No	0	5	8
23	R:R:L112	R:R:L391	5.54	Yes	Yes	0	8	8
24	R:R:L112	R:R:T394	7.37	Yes	No	0	8	8
25	R:R:M199	R:R:P115	3.35	Yes	No	0	7	5
26	R:R:L391	R:R:N117	5.49	Yes	No	0	8	9
27	R:R:M199	R:R:Y118	4.79	Yes	No	0	7	5
28	R:R:I176	R:R:L119	5.71	Yes	No	0	9	8
29	R:R:D179	R:R:L119	4.07	No	No	0	9	8
30	R:R:L119	R:R:M199	5.65	No	Yes	0	8	7
31	R:R:I120	R:R:I176	4.42	No	Yes	2	8	9
32	R:R:I120	R:R:Y384	4.84	No	Yes	2	8	9
33	R:R:S122	R:R:T172	4.8	No	No	0	9	8
34	R:R:I203	R:R:S122	10.84	No	No	0	7	9
35	R:R:D127	R:R:L123	4.07	Yes	No	6	9	9
36	R:R:L123	R:R:T172	7.37	No	No	0	9	8
37	R:R:L123	R:R:N380	4.12	No	No	6	9	9
38	R:R:D127	R:R:S377	10.31	Yes	No	0	9	9
39	R:R:D127	R:R:N380	9.42	Yes	No	6	9	9
40	R:R:C165	R:R:S129	3.44	No	No	0	7	6
41	R:R:V130	R:R:V134	6.41	No	Yes	0	8	8
42	R:R:M135	R:R:V130	4.56	No	No	0	8	8
43	R:R:D162	R:R:V134	10.22	No	Yes	1	7	8
44	R:R:C165	R:R:V134	3.42	No	Yes	0	7	8
45	R:R:V134	R:R:Y374	3.79	Yes	Yes	1	8	7
46	R:R:M135	R:R:Y374	10.78	No	Yes	0	8	7
47	R:R:F137	R:R:F154	8.57	No	Yes	0	5	5
48	R:R:D142	R:R:V138	8.76	No	No	9	4	7
49	R:R:R367	R:R:V138	3.92	No	No	9	5	7
50	R:R:S139	R:R:W371	4.94	Yes	No	5	6	6
51	R:R:D142	R:R:T141	7.23	No	No	0	4	4
52	R:R:F150	R:R:T141	3.89	Yes	No	0	6	4
53	R:R:D142	R:R:R367	13.1	No	No	9	4	5
54	R:R:K147	R:R:K229	5.75	No	No	0	4	2
55	R:R:F150	R:R:W148	7.02	Yes	Yes	4	6	8
56	R:R:F154	R:R:W148	7.02	Yes	Yes	4	5	8
57	R:R:C155	R:R:W148	5.22	No	Yes	4	9	8
58	R:R:F158	R:R:W148	7.02	No	Yes	0	6	8
59	R:R:C231	R:R:W148	18.28	No	Yes	4	9	8
60	R:R:F150	R:R:F154	11.79	Yes	Yes	4	6	5
61	R:R:H152	R:R:N226	10.2	No	No	0	3	3
62	R:R:F153	R:R:V157	3.93	No	No	0	1	4
63	R:R:C155	R:R:N226	7.87	No	No	0	9	3
64	R:R:C155	R:R:C231	7.28	No	No	4	9	9
65	R:R:N156	R:R:N224	8.17	No	No	0	5	3
66	R:R:I159	R:R:N224	5.66	No	No	0	6	3
67	R:R:I159	R:R:I233	4.42	No	No	0	6	4
68	R:R:A160	R:R:T214	5.03	No	No	0	6	7
69	R:R:D162	R:R:Y374	5.75	No	Yes	1	7	7
70	L:L:?1	R:R:D162	9.55	Yes	No	1	0	7
71	R:R:I213	R:R:V163	4.61	No	No	0	6	6
72	L:L:?1	R:R:V163	15.73	Yes	No	0	0	6
73	R:R:M164	R:R:W207	4.65	No	No	0	5	9
74	R:R:C166	R:R:W340	5.22	No	Yes	1	7	8
75	L:L:?1	R:R:C166	5.59	Yes	No	1	0	7
76	R:R:S210	R:R:T167	6.4	No	No	0	8	7
77	R:R:A247	R:R:T167	5.03	No	No	0	7	7
78	R:R:A168	R:R:W207	7.78	No	No	0	7	9
79	R:R:A168	R:R:S210	3.42	No	No	0	7	8
80	R:R:F336	R:R:I170	5.02	No	No	0	9	8
81	R:R:I170	R:R:W340	5.87	No	Yes	0	8	8
82	R:R:M171	R:R:V206	4.56	No	No	0	6	7
83	R:R:L209	R:R:M171	9.9	No	No	0	5	6
84	R:R:M171	R:R:P251	3.35	No	No	0	6	9
85	R:R:L173	R:R:Y384	7.03	No	Yes	0	8	9
86	R:R:C174	R:R:V254	3.42	No	No	0	7	6
87	R:R:I176	R:R:R180	3.76	Yes	No	2	9	9
88	R:R:I176	R:R:Y384	7.25	Yes	Yes	2	9	9
89	R:R:M255	R:R:S177	6.13	No	No	2	8	8
90	R:R:S177	R:R:Y259	10.17	No	Yes	2	8	9
91	R:R:D179	R:R:Y190	6.9	No	Yes	8	9	8
92	R:R:D179	R:R:Q194	5.22	No	No	8	9	6
93	R:R:R180	R:R:Y384	4.12	No	Yes	2	9	9
94	R:R:T185	R:R:Y181	9.99	No	Yes	0	6	8
95	R:R:M258	R:R:Y181	13.17	No	Yes	0	6	8
96	R:R:Q261	R:R:Y181	9.02	No	Yes	0	5	8
97	R:R:I262	R:R:Y181	3.63	No	Yes	0	9	8
98	R:R:L182	R:R:R186	4.86	No	No	0	4	5
99	R:R:L182	R:R:Y190	14.07	No	Yes	0	4	8
100	R:R:I184	R:R:I262	8.83	No	No	0	9	9
101	R:R:R193	R:R:T189	5.17	No	No	0	4	4
102	R:R:Q194	R:R:Y190	11.27	No	Yes	8	6	8
103	R:R:P191	R:R:Q194	4.74	No	No	0	5	6
104	R:R:G196	R:R:N195	3.39	No	No	0	3	8
105	R:R:K197	R:R:N195	6.99	No	No	0	5	8
106	R:R:C198	R:R:N195	4.72	No	No	0	6	8
107	R:R:G196	R:R:M199	3.49	No	Yes	0	3	7
108	R:R:C198	R:R:M202	4.86	No	No	0	6	6
109	R:R:L209	R:R:S212	4.5	No	No	0	5	4
110	R:R:F219	R:R:L215	7.31	No	No	0	5	5
111	R:R:P216	R:R:P217	5.84	Yes	No	10	6	6
112	R:R:P216	R:R:Y239	6.95	Yes	Yes	10	6	7
113	R:R:P217	R:R:Y239	11.13	No	Yes	10	6	7
114	R:R:G220	R:R:Q223	4.93	No	No	0	5	3
115	R:R:A222	R:R:S234	3.42	No	No	0	5	3
116	R:R:A222	R:R:Y239	5.34	No	Yes	0	5	7
117	R:R:N224	R:R:N226	5.45	No	No	0	3	3
118	R:R:L232	R:R:V225	4.47	No	No	0	3	1
119	R:R:L232	R:R:Q235	3.99	No	No	0	3	4
120	R:R:I233	R:R:Y239	4.84	No	Yes	0	4	7
121	L:L:?1	R:R:I233	6.28	Yes	No	0	0	4
122	R:R:Q235	R:R:R350	5.84	No	Yes	0	4	3
123	R:R:F237	R:R:P351	10.11	No	No	0	3	5
124	R:R:F237	R:R:F352	5.36	No	No	0	3	5
125	R:R:S243	R:R:Y239	6.36	No	Yes	0	6	7
126	R:R:V246	R:R:Y242	8.83	No	No	0	4	5
127	L:L:?1	R:R:S243	9.25	Yes	No	0	0	6
128	R:R:T244	R:R:Y249	8.74	No	Yes	1	6	5
129	R:R:F344	R:R:T244	6.49	Yes	No	1	7	6
130	R:R:T244	R:R:T348	4.71	No	No	1	6	6
131	L:L:?1	R:R:A247	4.16	Yes	No	0	0	7
132	R:R:F248	R:R:Y249	5.16	Yes	Yes	0	7	5
133	R:R:F248	R:R:M252	7.46	Yes	Yes	0	7	6
134	R:R:F248	R:R:L341	4.87	Yes	Yes	0	7	6
135	R:R:F248	R:R:F344	23.58	Yes	Yes	0	7	7
136	R:R:T348	R:R:Y249	9.99	No	Yes	1	6	5
137	R:R:I250	R:R:P251	3.39	No	No	0	6	9
138	R:R:L256	R:R:M252	9.9	No	Yes	0	5	6
139	R:R:F336	R:R:M252	6.22	No	Yes	0	9	6
140	R:R:M252	R:R:T337	4.52	Yes	No	0	6	6
141	R:R:M255	R:R:Y259	5.99	No	Yes	2	8	9
142	R:R:F336	R:R:M255	8.71	No	No	0	9	8
143	R:R:F257	R:R:M258	3.73	No	No	0	4	6
144	R:R:F257	R:R:Q261	16.4	No	No	0	4	5
145	R:R:L329	R:R:Y259	3.52	Yes	Yes	0	8	9
146	R:R:I332	R:R:Y259	3.63	No	Yes	0	8	9
147	R:R:Y259	R:R:Y384	3.97	Yes	Yes	2	9	9
148	R:R:R267	R:R:Y263	5.14	No	No	0	5	5
149	R:R:A326	R:R:Y263	5.34	No	No	0	7	5
150	R:R:L329	R:R:Y263	3.52	Yes	No	0	8	5
151	R:R:H273	R:R:K272	6.55	No	No	0	5	4
152	R:R:F275	R:R:P276	4.33	No	No	0	3	3
153	R:R:F275	R:R:F278	31.08	No	No	0	3	1
154	R:R:F387	R:R:T328	12.97	No	No	0	7	9
155	R:R:F387	R:R:I331	6.28	No	No	0	7	7
156	R:R:L341	R:R:T337	4.42	Yes	No	0	6	6
157	R:R:C339	R:R:N376	6.3	No	No	0	9	9
158	R:R:F344	R:R:W340	4.01	Yes	Yes	1	7	8
159	R:R:G373	R:R:W340	8.44	No	Yes	0	7	8
160	R:R:N376	R:R:W340	16.95	No	Yes	0	9	8
161	L:L:?1	R:R:W340	4.01	Yes	Yes	1	0	8
162	R:R:L341	R:R:P342	3.28	Yes	No	0	6	9
163	R:R:L341	R:R:L345	8.3	Yes	No	0	6	6
164	R:R:F369	R:R:P342	10.11	No	No	0	5	9
165	R:R:F343	R:R:L370	7.31	No	No	0	7	6
166	L:L:?1	R:R:F343	7.5	Yes	No	0	0	7
167	L:L:?1	R:R:F344	12.86	Yes	Yes	1	0	7
168	R:R:L346	R:R:R350	3.64	No	Yes	0	5	3
169	R:R:F369	R:R:L346	8.53	No	No	0	5	5
170	L:L:?1	R:R:S347	9.25	Yes	No	0	0	6
171	R:R:I361	R:R:R350	6.26	No	Yes	3	4	3
172	R:R:E366	R:R:R350	4.65	No	Yes	3	4	3
173	R:R:I361	R:R:P362	3.39	No	No	3	4	3
174	R:R:E366	R:R:I361	9.56	No	No	3	4	4
175	R:R:P362	R:R:W364	9.46	No	No	3	3	1
176	R:R:P362	R:R:V365	5.3	No	No	3	3	5
177	R:R:L363	R:R:R367	3.64	No	No	0	1	5
178	R:R:V365	R:R:W364	9.81	No	No	3	5	1
179	R:R:F369	R:R:T368	3.89	No	No	0	5	4
180	R:R:L370	R:R:Y374	14.07	No	Yes	0	6	7
181	R:R:N376	R:R:N380	10.9	No	No	0	9	9
182	R:R:F382	R:R:I379	3.77	No	No	0	7	6
183	R:R:I383	R:R:Y384	3.63	No	Yes	0	8	9
184	R:R:F386	R:R:F387	7.5	No	No	0	5	7
185	R:R:D390	R:R:N388	13.46	No	No	7	6	8
186	R:R:L391	R:R:N388	6.87	Yes	No	7	8	8
187	R:R:D390	R:R:L391	8.14	No	Yes	7	6	8
188	R:R:L391	R:R:Y395	4.69	Yes	Yes	0	8	7
189	R:R:C401	R:R:S397	3.44	No	No	0	9	4
190	R:R:L399	R:R:Q400	3.99	No	No	0	6	4
191	R:R:Q402	R:R:Y403	9.02	No	No	0	2	3
192	R:R:C174	R:R:I178	3.27	No	No	0	7	6
193	R:R:N99	R:R:P381	3.26	Yes	No	0	9	9
194	R:R:A131	R:R:I96	3.25	No	No	0	7	6
195	R:R:A133	R:R:M161	3.22	No	No	0	5	5
196	R:R:S139	R:R:T92	3.2	Yes	No	0	6	6
197	R:R:T214	R:R:V163	3.17	No	No	0	7	6
198	R:R:P115	R:R:Q114	3.16	No	No	0	5	7
199	R:R:R113	R:R:Y118	3.09	No	No	0	8	5
200	R:R:I96	R:R:T92	3.04	No	No	0	6	6
201	R:R:M202	R:R:V175	3.04	No	No	0	6	6
202	R:R:M258	R:R:V254	3.04	No	No	0	6	6
203	R:R:L101	R:R:S105	3	No	No	0	7	8
204	R:R:L125	R:R:V103	2.98	No	No	0	6	7
205	R:R:L112	R:R:V106	2.98	Yes	No	0	8	8
206	R:R:L125	R:R:V121	2.98	No	No	0	6	5
207	R:R:L128	R:R:V132	2.98	No	No	0	8	4
208	R:R:L209	R:R:V246	2.98	No	No	0	5	4
209	R:R:L256	R:R:V333	2.98	No	No	0	5	8
210	R:R:L93	R:R:T89	2.95	No	No	0	5	4
211	R:R:D127	R:R:S169	2.94	Yes	No	0	9	9
212	R:R:I379	R:R:I383	2.94	No	No	0	6	8
213	R:R:I149	R:R:K229	2.91	No	No	0	3	2
214	R:R:P351	R:R:R350	2.88	No	Yes	0	5	3
215	R:R:I91	R:R:L378	2.85	No	No	0	7	7
216	R:R:I262	R:R:L329	2.85	No	Yes	0	9	8
217	R:R:G151	R:R:W148	2.81	No	Yes	0	7	8
218	R:R:H273	R:R:S269	2.79	No	No	0	5	7
219	R:R:P216	R:R:W221	2.7	Yes	No	0	6	6
220	R:R:F154	R:R:V157	2.62	Yes	No	0	5	4
221	L:L:?1	R:R:T240	2.59	Yes	No	0	0	6
222	R:R:V102	R:R:Y395	2.52	No	Yes	0	9	7
223	R:R:F150	R:R:I149	2.51	Yes	No	0	6	3
224	R:R:L398	R:R:Y395	2.34	No	Yes	0	5	7
225	R:R:R392	R:R:R396	2.13	No	No	0	9	4
226	R:R:G145	R:R:G146	2.11	No	No	0	4	3
227	R:R:R193	R:R:Y190	2.06	No	Yes	0	4	8
228	R:R:A97	R:R:G98	1.95	No	No	0	3	8
229	R:R:C174	R:R:P251	1.88	No	No	0	7	9
230	R:R:G334	R:R:V333	1.84	No	No	0	5	8
231	R:R:A266	R:R:A325	1.79	No	No	0	8	8
232	R:R:P381	R:R:V102	1.77	No	No	0	9	9
233	R:R:G85	R:R:I84	1.76	No	No	0	5	4
234	R:R:G145	R:R:I144	1.76	No	No	0	4	5
235	R:R:G98	R:R:L101	1.71	No	No	0	8	7
236	R:R:G183	R:R:L182	1.71	No	No	0	8	4
237	R:R:D236	R:R:G238	1.68	No	No	0	5	3
238	R:R:C100	R:R:I104	1.64	No	No	0	4	5
239	R:R:L215	R:R:P216	1.64	No	Yes	0	5	6
240	R:R:C165	R:R:M161	1.62	No	No	0	7	5
241	R:R:A211	R:R:M164	1.61	No	No	0	5	5
242	R:R:S139	R:R:T89	1.6	Yes	No	0	6	4
243	R:R:T141	R:R:V140	1.59	No	No	0	4	4
244	R:R:A325	R:R:L329	1.58	No	Yes	0	8	8
245	R:R:I87	R:R:V83	1.54	No	No	0	5	4
246	R:R:I144	R:R:V140	1.54	No	No	0	5	4
247	R:R:I241	R:R:T348	1.52	No	No	0	6	6
248	R:R:I331	R:R:T327	1.52	No	No	0	7	7
249	R:R:I332	R:R:T328	1.52	No	No	0	8	9
250	R:R:F237	R:R:G238	1.51	No	No	0	3	3
251	R:R:F278	R:R:G277	1.51	No	No	0	1	2
252	R:R:I87	R:R:I91	1.47	No	No	0	5	7
253	R:R:D227	R:R:V230	1.46	No	No	0	1	3
254	R:R:P187	R:R:R186	1.44	No	No	0	8	5
255	R:R:F278	R:R:P279	1.44	No	No	0	1	2
256	R:R:C107	R:R:F108	1.4	No	No	0	4	4
257	R:R:L378	R:R:L94	1.38	No	No	0	7	4
258	R:R:D227	R:R:K229	1.38	No	No	0	1	2
259	R:R:A270	R:R:R267	1.38	No	No	0	5	5
260	R:R:D227	R:R:D228	1.33	No	No	0	1	2
261	R:R:A245	R:R:Y249	1.33	No	Yes	0	4	5
262	R:R:A385	R:R:Y395	1.33	No	Yes	0	7	7
263	R:R:A126	R:R:W207	1.3	No	No	0	8	9
264	R:R:F219	R:R:L218	1.22	No	No	0	5	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:T95	4.91	4	0	8
2	R:R:N99	5.65	4	0	9
3	R:R:L112	5.835	4	0	8
4	R:R:D127	6.964	5	6	9
5	R:R:V134	5.96	4	1	8
6	R:R:S139	4.3125	4	5	6
7	R:R:W148	7.895	6	4	8
8	R:R:F150	6.3025	4	4	6
9	R:R:F154	7.5	4	4	5
10	R:R:I176	5.285	4	2	9
11	R:R:Y181	8.9525	4	0	8
12	R:R:Y190	8.575	4	8	8
13	R:R:M199	4.32	4	0	7
14	R:R:P216	4.2825	4	10	6
15	R:R:Y239	6.924	5	10	7
16	R:R:F248	10.2675	4	0	7
17	R:R:Y249	6.305	4	1	5
18	R:R:M252	7.025	4	0	6
19	R:R:Y259	5.456	5	2	9
20	R:R:L329	2.8675	4	0	8
21	R:R:W340	7.41667	6	1	8
22	R:R:L341	5.2175	4	0	6
23	R:R:F344	11.735	4	1	7
24	R:R:R350	4.654	5	3	3
25	R:R:Y374	8.5975	4	1	7
26	R:R:Y384	5.14	6	2	9
27	R:R:L391	6.146	5	7	8
28	R:R:Y395	3.448	5	0	7
29	L:L:?1	7.88818	11	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L88	R:R:S139	10.9045	7.51	No	Yes	5	6	6
2	R:R:S139	R:R:T92	19.4372	3.2	Yes	No	0	6	6
3	R:R:I96	R:R:T92	23.6054	3.04	No	No	0	6	6
4	R:R:A131	R:R:I96	25.6684	3.25	No	No	0	7	6
5	R:R:A131	R:R:T95	27.7174	3.36	No	Yes	0	7	8
6	R:R:L378	R:R:T95	13.0868	7.37	No	Yes	0	7	8
7	R:R:N99	R:R:T95	33.2257	4.39	Yes	Yes	0	9	8
8	R:R:M135	R:R:T95	44.025	4.52	No	Yes	0	8	8
9	R:R:D127	R:R:N99	51.1192	8.08	Yes	Yes	0	9	9
10	R:R:L128	R:R:N99	13.0868	6.87	No	Yes	0	8	9
11	R:R:P381	R:R:V102	45.5336	1.77	No	No	0	9	9
12	R:R:N99	R:R:P381	47.4423	3.26	Yes	No	0	9	9
13	R:R:V102	R:R:Y395	41.6743	2.52	No	Yes	0	9	7
14	R:R:L391	R:R:Y395	27.7244	4.69	Yes	Yes	0	8	7
15	R:R:L112	R:R:L391	19.4443	5.54	Yes	Yes	0	8	8
16	R:R:D127	R:R:N380	51.7648	9.42	Yes	No	6	9	9
17	R:R:N376	R:R:N380	57.9047	10.9	No	No	0	9	9
18	R:R:N376	R:R:W340	59.7011	16.95	No	Yes	0	9	8
19	R:R:I170	R:R:W340	78.4857	5.87	No	Yes	0	8	8
20	R:R:F336	R:R:I170	77.9735	5.02	No	No	0	9	8
21	R:R:F336	R:R:M255	100	8.71	No	No	0	9	8
22	R:R:M255	R:R:Y259	97.4177	5.99	No	Yes	2	8	9
23	R:R:Y259	R:R:Y384	54.5927	3.97	Yes	Yes	2	9	9
24	R:R:I176	R:R:Y384	43.1057	7.25	Yes	Yes	2	9	9
25	R:R:I176	R:R:L119	41.7936	5.71	Yes	No	0	9	8
26	R:R:L119	R:R:M199	22.7282	5.65	No	Yes	0	8	7
27	R:R:M135	R:R:Y374	42.4672	10.78	No	Yes	0	8	7
28	R:R:D162	R:R:Y374	40.4393	5.75	No	Yes	1	7	7
29	L:L:?1	R:R:D162	48.7615	9.55	Yes	No	1	0	7
30	L:L:?1	R:R:W340	65.8129	4.01	Yes	Yes	1	0	8
31	R:R:D179	R:R:L119	19.0794	4.07	No	No	0	9	8
32	R:R:C155	R:R:W148	38.692	5.22	No	Yes	4	9	8
33	R:R:C155	R:R:N226	41.8848	7.87	No	No	0	9	3
34	R:R:N224	R:R:N226	44.86	5.45	No	No	0	3	3
35	R:R:I159	R:R:N224	47.7791	5.66	No	No	0	6	3
36	R:R:I159	R:R:I233	49.2176	4.42	No	No	0	6	4
37	L:L:?1	R:R:I233	62.4447	6.28	Yes	No	0	0	4
38	R:R:F150	R:R:T141	16.062	3.89	Yes	No	0	6	4
39	R:R:F150	R:R:W148	27.3525	7.02	Yes	Yes	4	6	8
40	R:R:F150	R:R:I149	10.8554	2.51	Yes	No	0	6	3
41	L:L:?1	R:R:A247	14.813	4.16	Yes	No	0	0	7
42	R:R:A247	R:R:T167	13.0096	5.03	No	No	0	7	7
43	R:R:S210	R:R:T167	11.1922	6.4	No	No	0	8	7
44	R:R:L329	R:R:Y259	46.6704	3.52	Yes	Yes	0	8	9
45	R:R:I262	R:R:L329	35.0291	2.85	No	Yes	0	9	8
46	R:R:I262	R:R:Y181	31.5767	3.63	No	Yes	0	9	8
47	R:R:M258	R:R:Y181	24.4053	13.17	No	Yes	0	6	8
48	R:R:M258	R:R:V254	20.8827	3.04	No	No	0	6	6
49	R:R:C174	R:R:V254	19.0513	3.42	No	No	0	7	6
50	R:R:C174	R:R:P251	15.3463	1.88	No	No	0	7	9
51	R:R:M171	R:R:P251	11.5852	3.35	No	No	0	6	9
52	R:R:D179	R:R:Y190	13.4026	6.9	No	Yes	8	9	8
53	R:R:G196	R:R:M199	11.6132	3.49	No	Yes	0	3	7
54	R:R:L215	R:R:P216	10.1396	1.64	No	Yes	0	5	6
55	R:R:P216	R:R:Y239	16.7988	6.95	Yes	Yes	10	6	7
56	R:R:I233	R:R:Y239	16.1883	4.84	No	Yes	0	4	7
57	R:R:S243	R:R:Y239	14.2937	6.36	No	Yes	0	6	7
58	L:L:?1	R:R:S243	15.7884	9.25	Yes	No	0	0	6
59	L:L:?1	R:R:F344	23.8159	12.86	Yes	Yes	1	0	7
60	R:R:F248	R:R:F344	29.9768	23.58	Yes	Yes	0	7	7
61	R:R:F248	R:R:L341	32.0469	4.87	Yes	Yes	0	7	6
62	R:R:L341	R:R:P342	37.3798	3.28	Yes	No	0	6	9
63	R:R:F369	R:R:P342	35.4221	10.11	No	No	0	5	9
64	R:R:F369	R:R:L346	31.4645	8.53	No	No	0	5	5
65	R:R:L346	R:R:R350	29.4646	3.64	No	Yes	0	5	3
66	R:R:P351	R:R:R350	10.8343	2.88	No	Yes	0	5	3
67	R:R:F248	R:R:M252	19.0723	7.46	Yes	Yes	0	7	6
68	R:R:M252	R:R:T337	11.943	4.52	Yes	No	0	6	6
69	R:R:L341	R:R:T337	11.2764	4.42	Yes	No	0	6	6
70	R:R:I332	R:R:Y259	11.6132	3.63	No	Yes	0	8	9
71	R:R:F344	R:R:W340	11.6974	4.01	Yes	Yes	1	7	8
72	R:R:F336	R:R:M252	26.756	6.22	No	Yes	0	9	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D162	R:R:V134	10.22	1	No	Yes	7	8	1	2
R:R:V134	R:R:Y374	3.79	1	Yes	Yes	8	7	2	2
R:R:I159	R:R:I233	4.42	0	No	No	6	4	2	1
R:R:D162	R:R:Y374	5.75	1	No	Yes	7	7	1	2
L:L:?1	R:R:D162	9.55	1	Yes	No	0	7	0	1
R:R:I213	R:R:V163	4.61	0	No	No	6	6	2	1
L:L:?1	R:R:V163	15.73	1	Yes	No	0	6	0	1
R:R:C166	R:R:W340	5.22	1	No	Yes	7	8	1	1
L:L:?1	R:R:C166	5.59	1	Yes	No	0	7	0	1
R:R:A247	R:R:T167	5.03	0	No	No	7	7	1	2
R:R:I170	R:R:W340	5.87	0	No	Yes	8	8	2	1
R:R:I233	R:R:Y239	4.84	0	No	Yes	4	7	1	2
L:L:?1	R:R:I233	6.28	1	Yes	No	0	4	0	1
R:R:S243	R:R:Y239	6.36	0	No	Yes	6	7	1	2
L:L:?1	R:R:S243	9.25	1	Yes	No	0	6	0	1
R:R:F344	R:R:T244	6.49	1	Yes	No	7	6	1	2
L:L:?1	R:R:A247	4.16	1	Yes	No	0	7	0	1
R:R:F248	R:R:F344	23.58	0	Yes	Yes	7	7	2	1
R:R:F344	R:R:W340	4.01	1	Yes	Yes	7	8	1	1
R:R:G373	R:R:W340	8.44	0	No	Yes	7	8	2	1
R:R:N376	R:R:W340	16.95	0	No	Yes	9	8	2	1
L:L:?1	R:R:W340	4.01	1	Yes	Yes	0	8	0	1
R:R:F343	R:R:L370	7.31	0	No	No	7	6	1	2
L:L:?1	R:R:F343	7.5	1	Yes	No	0	7	0	1
L:L:?1	R:R:F344	12.86	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:S347	9.25	1	Yes	No	0	6	0	1
R:R:L370	R:R:Y374	14.07	0	No	Yes	6	7	2	2
R:R:T214	R:R:V163	3.17	0	No	No	7	6	2	1
L:L:?1	R:R:T240	2.59	1	Yes	No	0	6	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7XTC_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.28
Number of Linked Nodes	246
Number of Links	264
Number of Hubs	29
Number of Links mediated by Hubs	116
Number of Communities	10
Number of Nodes involved in Communities	46
Number of Links involved in Communities	53

Path Summary
Number Of Nodes in MetaPath	73
Number Of Links MetaPath	72
Number of Shortest Paths	33833
Length Of Smallest Path	3
Average Path Length	13.4915
Length of Longest Path	29
Minimum Path Strength	1.355
Average Path Strength	6.19261
Maximum Path Strength	18.22
Minimum Path Correlation	0.7
Average Path Correlation	0.957981
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.16667
Average % Of Corr. Nodes	69.4126
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	38.7727
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • molecular function activator activity • phosphorus-oxygen lyase activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • adenylate cyclase activator activity • adenylate cyclase activity • cation binding • metal ion binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • biological regulation • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of biological process • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • protein localization • regulation of localization • establishment of protein localization • nitrogen compound transport • localization • cellular macromolecule localization • regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • protein transport • regulation of cellular localization • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • neurotransmitter receptor activity • molecular transducer activity • signaling receptor activity • serotonin receptor activity • transmembrane signaling receptor activity • G protein-coupled amine receptor activity • G protein-coupled serotonin receptor activity • G protein-coupled receptor activity • tetrapyrrole binding • heme binding • electron transfer activity • cation binding • transition metal ion binding • iron ion binding • ion binding • metal ion binding • small molecule binding • rhythmic process • circadian rhythm • serotonin receptor signaling pathway • adenylate cyclase-activating serotonin receptor signaling pathway • trans-synaptic signaling • anterograde trans-synaptic signaling • chemical synaptic transmission • smooth muscle contraction • muscle contraction • muscle system process • regulation of tube diameter • regulation of tube size • circulatory system process • vascular process in circulatory system • blood vessel diameter maintenance • regulation of biological quality • vasoconstriction • blood circulation • regulation of anatomical structure size • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • electron transport chain • metabolic process • generation of precursor metabolites and energy • somatodendritic compartment • dendrite • dendritic tree • nucleus • membrane-enclosed lumen • intracellular organelle lumen • nucleoplasm • organelle lumen • nuclear lumen • periplasmic space
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	8K3
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	8K3
Name	3-(2-azanylethyl)-1H-indole-5-carboxamide
Synonyms
Identifier
Formula	C11 H13 N3 O
Molecular Weight	203.24
SMILES
PubChem	1809
Formal Charge	0
Total Atoms	28
Total Chiral Atoms	0
Total Bonds	29
Total Aromatic Bonds	10


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P34969
Sequence	>7XTC_nogp_Chain_R E K V V I G S I L T L I T L L T I A G N C L V V I S V C F V K K L R Q P S N Y L I V S L A L A D L S V A V A V M P F V S V T D L I G G K W I F G H F F C N V F I A M D V M C C T A S I M T L C V I S I D R Y L G I T R P L T Y P V R Q N G K C M A K M I L S V W L L S A S I T L P P L F G W A Q N V N D D K V C L I S Q D F G Y T I Y S T A V A F Y I P M S V M L F M Y Y Q I Y K A A R K S A A K H K F P G F P K A A T T L G I I V G A F T V C W L P F F L L S T A R P F I C C I P L W V E R T F L W L G Y A N S L I N P F I Y A F F N R D L R T T Y R S L L Q C Q Y Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7XTC	A	Amine	5-Hydroxytryptamine	5-HT₇	Homo sapiens	5-CT	-	Gs/β1/γ2	3.2	2022-07-27	10.1016/j.molcel.2022.05.031
	7XTC (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT₇	Homo sapiens	5-CT	-		3.2	2022-07-27	10.1016/j.molcel.2022.05.031

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