psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	A:A:Q12	A:A:T9	4.25	No	No	0	2	6
2	A:A:K17	A:A:R13	4.95	No	No	0	4	4
3	A:A:E15	A:A:E16	5.07	No	No	7	6	4
4	A:A:E15	A:A:Q19	14.02	No	Yes	7	6	4
5	A:A:E16	A:A:Q19	3.82	No	Yes	7	4	4
6	A:A:K17	A:A:R20	3.71	No	No	0	4	3
7	A:A:Q19	B:B:D83	5.22	Yes	No	7	4	8
8	A:A:Q19	B:B:T86	9.92	Yes	No	7	4	6
9	A:A:Q19	B:B:N88	15.85	Yes	No	7	4	7
10	A:A:N23	B:B:N88	13.62	No	No	0	7	7
11	A:A:I26	B:B:A92	3.25	No	No	0	9	6
12	A:A:E27	B:B:K89	5.4	No	Yes	0	6	9
13	A:A:K28	A:A:K32	5.75	No	No	0	4	4
14	A:A:K34	A:A:R38	8.66	No	No	0	4	4
15	A:A:K34	B:B:L55	9.87	No	No	0	4	6
16	A:A:R42	A:A:Y37	9.26	Yes	Yes	1	9	4
17	A:A:Y37	B:B:L55	3.52	Yes	No	1	4	6
18	A:A:Y37	B:B:Q75	4.51	Yes	Yes	1	4	9
19	A:A:Y37	B:B:D76	4.6	Yes	Yes	1	4	9
20	A:A:N218	A:A:T40	7.31	No	No	0	4	7
21	A:A:H41	A:A:I383	6.63	No	Yes	0	6	8
22	A:A:H220	A:A:R42	5.64	Yes	Yes	1	7	9
23	A:A:D240	A:A:R42	4.76	No	Yes	0	6	9
24	A:A:R42	B:B:Q75	14.02	Yes	Yes	1	9	9
25	A:A:L43	A:A:T242	2.95	No	No	0	7	8
26	A:A:I245	A:A:L43	4.28	Yes	No	0	7	7
27	A:A:F222	A:A:L44	3.65	Yes	No	1	7	9
28	A:A:F238	A:A:L44	20.7	Yes	No	1	9	9
29	A:A:L45	A:A:M221	4.24	No	No	0	8	8
30	A:A:D223	A:A:L45	6.79	No	No	0	9	8
31	A:A:I245	A:A:L45	4.28	Yes	No	0	7	8
32	A:A:F246	A:A:L46	7.31	Yes	No	0	9	8
33	A:A:D223	A:A:F208	5.97	No	No	0	9	5
34	A:A:F208	A:A:G226	4.52	No	No	0	5	9
35	A:A:E209	A:A:H220	11.08	Yes	Yes	1	9	7
36	A:A:E209	A:A:F222	5.83	Yes	Yes	1	9	7
37	A:A:E209	B:B:S97	5.75	Yes	No	0	9	8
38	A:A:E209	B:B:W99	6.54	Yes	Yes	1	9	9
39	A:A:H220	A:A:K211	13.1	Yes	No	0	7	4
40	A:A:F212	A:A:F219	9.65	Yes	Yes	0	9	8
41	A:A:N218	A:A:Q213	10.56	No	No	0	4	3
42	A:A:F219	A:A:V214	3.93	Yes	No	14	8	6
43	A:A:F376	A:A:V214	11.8	Yes	No	14	8	6
44	A:A:D215	A:A:F376	7.17	No	Yes	0	5	8
45	A:A:K216	R:R:E255	8.1	No	No	0	4	6
46	A:A:F219	A:A:V217	7.87	Yes	No	0	8	5
47	A:A:V217	R:R:F253	3.93	No	No	0	5	6
48	A:A:F219	A:A:F376	4.29	Yes	Yes	14	8	8
49	A:A:H220	B:B:S98	6.97	Yes	No	1	7	8
50	A:A:H220	B:B:W99	5.29	Yes	Yes	1	7	9
51	A:A:F222	A:A:V224	3.93	Yes	No	0	7	9
52	A:A:F222	A:A:F238	6.43	Yes	Yes	1	7	9
53	A:A:F222	B:B:W99	8.02	Yes	Yes	1	7	9
54	A:A:F222	B:B:L117	4.87	Yes	Yes	1	7	9
55	A:A:V224	A:A:W234	9.81	No	Yes	0	9	9
56	A:A:Q227	A:A:W234	6.57	Yes	Yes	0	9	9
57	A:A:Q227	B:B:L117	3.99	Yes	Yes	1	9	9
58	A:A:Q227	B:B:N119	6.6	Yes	No	0	9	9
59	A:A:Q227	B:B:Y145	5.64	Yes	Yes	1	9	8
60	A:A:E230	A:A:R228	11.63	No	No	1	9	9
61	A:A:R228	B:B:T164	6.47	No	No	0	9	6
62	A:A:R228	B:B:D186	4.76	No	Yes	1	9	9
63	A:A:E230	B:B:D186	3.9	No	Yes	1	9	9
64	A:A:R231	A:A:W234	10	No	Yes	0	9	9
65	A:A:L272	A:A:R231	6.07	No	No	0	8	9
66	A:A:R232	B:B:C204	6.96	No	Yes	0	8	7
67	A:A:R232	B:B:D228	8.34	No	Yes	0	8	9
68	A:A:K233	B:B:D186	8.3	Yes	Yes	1	9	9
69	A:A:K233	B:B:M188	10.08	Yes	No	1	9	8
70	A:A:K233	B:B:C204	4.85	Yes	Yes	1	9	7
71	A:A:K233	B:B:D228	9.68	Yes	Yes	1	9	9
72	A:A:F238	A:A:W234	3.01	Yes	Yes	0	9	9
73	A:A:Q236	A:A:W281	4.38	No	Yes	0	8	5
74	A:A:C237	B:B:M101	3.24	No	No	0	8	9
75	A:A:F238	B:B:W99	9.02	Yes	Yes	1	9	9
76	A:A:N239	B:B:K57	5.6	No	Yes	1	8	9
77	A:A:N239	B:B:W332	9.04	No	Yes	1	8	9
78	A:A:D240	B:B:K57	4.15	No	Yes	0	6	9
79	A:A:A243	A:A:I288	3.25	No	No	0	8	9
80	A:A:I244	A:A:I285	4.42	No	No	15	8	7
81	A:A:F246	A:A:F273	6.43	Yes	Yes	3	9	9
82	A:A:F246	A:A:I276	3.77	Yes	No	3	9	8
83	A:A:F246	A:A:V287	7.87	Yes	Yes	3	9	6
84	A:A:N264	A:A:Q267	5.28	No	No	0	9	4
85	A:A:N264	A:A:Y311	26.75	No	No	0	9	6
86	A:A:F312	A:A:L266	4.87	No	No	0	8	8
87	A:A:I341	A:A:L266	5.71	No	No	0	8	8
88	A:A:L270	A:A:Q267	3.99	Yes	No	0	6	4
89	A:A:F345	A:A:L270	12.18	No	Yes	0	8	6
90	A:A:I348	A:A:L270	4.28	No	Yes	0	4	6
91	A:A:N271	A:A:S275	4.47	No	No	0	5	8
92	A:A:F273	A:A:W277	7.02	Yes	Yes	3	9	6
93	A:A:F273	A:A:V287	7.87	Yes	Yes	3	9	6
94	A:A:F273	A:A:F345	7.5	Yes	No	0	9	8
95	A:A:F273	A:A:I348	10.05	Yes	No	0	9	4
96	A:A:F273	A:A:S349	3.96	Yes	No	3	9	7
97	A:A:C359	A:A:F273	4.19	No	Yes	3	5	9
98	A:A:K274	A:A:N278	4.2	No	No	0	5	8
99	A:A:I348	A:A:K274	4.36	No	No	0	4	5
100	A:A:I276	A:A:V287	3.07	No	Yes	3	8	6
101	A:A:S349	A:A:W277	11.12	No	Yes	3	7	6
102	A:A:S352	A:A:W277	6.18	No	Yes	0	5	6
103	A:A:D354	A:A:W277	4.47	Yes	Yes	3	3	6
104	A:A:H357	A:A:W277	29.62	No	Yes	3	7	6
105	A:A:N278	A:A:S352	2.98	No	No	0	8	5
106	A:A:L282	A:A:N279	8.24	No	No	0	9	8
107	A:A:R280	A:A:W281	13.99	No	Yes	0	5	5
108	A:A:W281	B:B:D290	4.47	Yes	Yes	1	5	6
109	A:A:W281	B:B:R314	13	Yes	Yes	1	5	8
110	A:A:D354	A:A:R283	4.76	Yes	No	3	3	3
111	A:A:R283	A:A:R356	7.46	No	No	3	3	2
112	A:A:I285	A:A:T284	3.04	No	No	0	7	4
113	A:A:I382	A:A:S286	3.1	No	No	0	6	8
114	A:A:L289	A:A:V287	2.98	No	Yes	0	9	6
115	A:A:I288	A:A:V375	3.07	No	No	0	9	9
116	A:A:D378	A:A:I288	8.4	No	No	0	7	9
117	A:A:F345	A:A:L289	8.53	No	No	0	8	9
118	A:A:F290	A:A:H362	3.39	No	No	0	9	9
119	A:A:F290	A:A:N371	12.08	No	No	0	9	9
120	A:A:N292	A:A:T364	14.62	No	No	0	9	9
121	A:A:E309	A:A:F315	4.66	No	No	0	4	6
122	A:A:F312	A:A:Y311	3.09	No	No	0	8	6
123	A:A:E314	A:A:F340	3.5	No	Yes	0	6	7
124	A:A:F315	A:A:F340	4.29	No	Yes	0	6	7
125	A:A:A316	A:A:R317	4.15	No	No	0	2	2
126	A:A:P321	A:A:Y318	5.56	No	Yes	0	5	6
127	A:A:R336	A:A:Y318	6.17	No	Yes	0	5	6
128	A:A:F340	A:A:Y318	14.44	Yes	Yes	0	7	6
129	A:A:D343	A:A:Y318	9.2	No	Yes	0	3	6
130	A:A:P321	A:A:T320	3.5	No	No	0	5	1
131	A:A:R336	A:A:T320	5.17	No	No	0	5	1
132	A:A:D331	A:A:P332	4.83	No	No	0	4	1
133	A:A:D331	A:A:R333	3.57	No	No	0	4	5
134	A:A:D331	A:A:V334	8.76	No	No	0	4	4
135	A:A:K338	A:A:T335	4.5	No	No	0	5	4
136	A:A:K338	A:A:Y339	5.97	No	No	0	5	3
137	A:A:F363	A:A:K338	7.44	No	No	0	5	5
138	A:A:R342	A:A:Y339	7.2	No	No	0	4	3
139	A:A:P361	A:A:R342	4.32	No	No	0	5	4
140	A:A:F363	A:A:R342	10.69	No	No	0	5	4
141	A:A:E344	A:A:R347	3.49	No	No	0	5	4
142	A:A:C359	A:A:S349	5.16	No	No	3	5	7
143	A:A:G353	A:A:S352	3.71	No	No	0	4	5
144	A:A:D354	A:A:G355	3.35	Yes	No	0	3	2
145	A:A:D354	A:A:R356	5.96	Yes	No	3	3	2
146	A:A:D354	A:A:H357	16.39	Yes	No	3	3	7
147	A:A:Y358	A:A:Y360	8.94	No	Yes	0	4	8
148	A:A:D378	A:A:Y360	13.79	No	Yes	0	7	8
149	A:A:D381	A:A:Y360	6.9	No	Yes	16	8	8
150	A:A:I382	A:A:Y360	6.04	No	Yes	0	6	8
151	A:A:R385	A:A:Y360	4.12	No	Yes	16	5	8
152	A:A:H362	A:A:R374	14.67	No	No	0	9	4
153	A:A:D378	A:A:H362	13.87	No	No	0	7	9
154	A:A:C365	A:A:T364	3.38	No	No	0	8	9
155	A:A:N377	A:A:R373	4.82	No	No	0	4	5
156	A:A:F376	A:A:N377	3.62	Yes	No	0	8	4
157	A:A:C379	A:A:I383	3.27	No	Yes	0	8	8
158	A:A:Q384	A:A:R380	5.84	Yes	No	17	6	7
159	A:A:R380	R:R:V252	3.92	No	No	17	7	7
160	A:A:D381	A:A:R385	15.48	No	No	16	8	5
161	A:A:H387	A:A:I383	5.3	Yes	Yes	0	8	8
162	A:A:I383	R:R:V252	3.07	Yes	No	0	8	7
163	A:A:Q384	R:R:V252	7.16	Yes	No	17	6	7
164	A:A:Q384	R:R:K326	10.85	Yes	No	0	6	9
165	A:A:L394	A:A:R385	3.64	No	No	0	8	5
166	A:A:H387	A:A:M386	3.94	Yes	No	0	8	3
167	A:A:H387	R:R:L247	7.71	Yes	No	0	8	8
168	A:A:H387	R:R:T254	4.11	Yes	No	0	8	6
169	A:A:L388	R:R:L323	4.15	No	No	0	8	9
170	A:A:L394	A:A:R389	10.93	No	No	0	8	4
171	A:A:Q390	R:R:R180	11.68	No	No	0	4	9
172	A:A:Y391	R:R:R180	7.2	Yes	No	0	4	9
173	A:A:Y391	R:R:Y243	2.98	Yes	Yes	0	4	8
174	A:A:Y391	R:R:L244	14.07	Yes	No	0	4	9
175	A:A:L393	R:R:T345	2.95	No	No	0	8	9
176	A:A:L394	R:R:M327	4.24	No	Yes	0	8	7
177	B:B:L4	G:G:I9	4.28	No	No	0	4	2
178	B:B:L4	G:G:R13	9.72	No	No	0	4	6
179	B:B:L7	G:G:R13	6.07	No	No	0	8	6
180	B:B:Q13	B:B:Q9	7.68	No	No	0	1	3
181	B:B:E10	B:B:Q13	5.1	No	No	0	8	1
182	B:B:A11	G:G:V16	3.39	No	No	0	5	7
183	B:B:L14	G:G:A23	3.15	No	No	0	8	8
184	B:B:K15	G:G:L19	4.23	No	No	0	6	9
185	B:B:N16	B:B:R19	4.82	No	No	0	1	4
186	B:B:D20	B:B:N16	4.04	No	No	0	2	1
187	B:B:I18	B:B:R22	5.01	Yes	No	0	7	6
188	B:B:I18	G:G:L19	4.28	Yes	No	0	7	9
189	B:B:I18	G:G:A23	3.25	Yes	No	0	7	8
190	B:B:I18	G:G:R27	3.76	Yes	Yes	0	7	8
191	B:B:A21	G:G:R27	5.53	No	Yes	0	4	8
192	B:B:D258	B:B:R22	3.57	Yes	No	0	7	6
193	B:B:A26	B:B:Q259	4.55	No	No	0	3	6
194	B:B:D27	G:G:K29	6.91	No	No	0	8	4
195	B:B:D27	G:G:S31	5.89	No	No	0	8	9
196	B:B:Q32	B:B:T29	7.09	No	No	0	1	3
197	B:B:L30	B:B:T34	5.9	Yes	No	0	5	5
198	B:B:L261	B:B:L30	8.3	No	Yes	18	5	5
199	B:B:L30	B:B:M262	4.24	Yes	Yes	0	5	4
200	B:B:M262	B:B:S31	4.6	Yes	No	0	4	1
201	B:B:L300	B:B:T34	8.84	Yes	No	0	6	5
202	B:B:T34	G:G:M38	3.01	No	No	0	5	4
203	B:B:I37	B:B:K301	4.36	No	No	0	2	5
204	B:B:D38	B:B:P39	6.44	No	No	0	1	1
205	B:B:K301	B:B:P39	11.71	No	No	0	5	1
206	B:B:V40	G:G:L51	2.98	No	Yes	0	3	6
207	B:B:Q44	B:B:R42	16.35	No	No	19	4	2
208	B:B:R42	R:R:Q415	17.52	No	No	19	2	1
209	B:B:Q44	R:R:Q415	19.2	No	No	19	4	1
210	B:B:K337	B:B:T47	13.51	Yes	No	0	6	3
211	B:B:T47	B:B:W339	10.92	No	No	0	3	9
212	B:B:I338	B:B:R49	6.26	No	No	11	5	7
213	B:B:R49	G:G:F61	5.34	No	Yes	11	7	8
214	B:B:R49	G:G:R62	4.26	No	No	0	7	7
215	B:B:R52	B:B:T50	9.06	No	No	0	7	3
216	B:B:K337	B:B:T50	10.51	Yes	No	0	6	3
217	B:B:L51	B:B:L70	4.15	Yes	No	5	9	5
218	B:B:L51	B:B:W82	18.22	Yes	Yes	5	9	9
219	B:B:L51	B:B:T87	2.95	Yes	No	0	9	5
220	B:B:L336	B:B:L51	5.54	No	Yes	0	7	9
221	B:B:F335	B:B:R52	7.48	No	No	0	4	7
222	B:B:R52	R:R:R174	4.26	No	No	0	7	7
223	B:B:G53	B:B:K89	3.49	No	Yes	0	9	9
224	B:B:H54	B:B:I58	10.61	Yes	No	0	9	9
225	B:B:H54	B:B:S72	9.76	Yes	No	5	9	9
226	B:B:H54	B:B:S74	6.97	Yes	No	0	9	9
227	B:B:H54	B:B:I80	11.93	Yes	Yes	5	9	8
228	B:B:H54	B:B:W82	7.41	Yes	Yes	5	9	9
229	B:B:D76	B:B:L55	8.14	Yes	No	1	9	6
230	B:B:A56	B:B:Q75	4.55	No	Yes	0	7	9
231	B:B:K57	B:B:Y59	5.97	Yes	Yes	1	9	8
232	B:B:K57	B:B:Q75	4.07	Yes	Yes	1	9	9
233	B:B:K57	B:B:W332	13.92	Yes	Yes	1	9	9
234	B:B:I58	B:B:L336	5.71	No	No	0	9	7
235	B:B:Q75	B:B:Y59	7.89	Yes	Yes	1	9	8
236	B:B:W332	B:B:Y59	5.79	Yes	Yes	1	9	8
237	B:B:A328	B:B:M61	3.22	No	No	0	5	6
238	B:B:H62	B:B:Y105	3.27	No	Yes	0	6	6
239	B:B:H62	B:B:R150	7.9	No	No	0	6	6
240	B:B:L70	B:B:W63	7.97	No	Yes	0	5	7
241	B:B:T321	B:B:W63	9.7	No	Yes	0	7	7
242	B:B:A328	B:B:W63	5.19	No	Yes	0	5	7
243	B:B:G64	B:B:Y105	4.35	No	Yes	0	5	6
244	B:B:D66	B:B:R68	3.57	No	Yes	0	8	5
245	B:B:S67	B:B:T321	7.99	No	No	20	5	7
246	B:B:D323	B:B:S67	8.83	No	No	20	7	5
247	B:B:L69	B:B:R68	4.86	No	Yes	0	5	5
248	B:B:D83	B:B:R68	15.48	No	Yes	0	8	5
249	B:B:R68	B:B:Y85	12.35	Yes	Yes	0	5	4
250	B:B:L70	B:B:W82	4.56	No	Yes	5	5	9
251	B:B:I81	B:B:V71	6.14	No	No	6	7	8
252	B:B:V71	B:B:Y105	5.05	No	Yes	6	8	6
253	B:B:V112	B:B:V71	3.21	Yes	No	6	8	8
254	B:B:S72	B:B:W82	7.41	No	Yes	5	9	9
255	B:B:L336	B:B:S72	3	No	No	0	7	9
256	B:B:D76	B:B:S74	8.83	Yes	No	0	9	9
257	B:B:Q75	B:B:W99	5.48	Yes	Yes	1	9	9
258	B:B:D76	B:B:K78	8.3	Yes	Yes	0	9	8
259	B:B:G77	B:B:L95	5.13	No	Yes	0	8	8
260	B:B:A92	B:B:K78	3.21	No	Yes	0	6	8
261	B:B:K78	B:B:P94	10.04	Yes	No	0	8	5
262	B:B:I93	B:B:L79	8.56	Yes	Yes	0	7	7
263	B:B:L79	B:B:L95	5.54	Yes	Yes	0	7	8
264	B:B:C103	B:B:L79	4.76	No	Yes	0	8	7
265	B:B:L79	B:B:V112	2.98	Yes	Yes	0	7	8
266	B:B:I80	B:B:W82	9.4	Yes	Yes	5	8	9
267	B:B:I80	B:B:K89	4.36	Yes	Yes	5	8	9
268	B:B:H91	B:B:I81	9.28	No	No	0	5	7
269	B:B:I81	B:B:V112	3.07	No	Yes	6	7	8
270	B:B:K89	B:B:W82	12.76	Yes	Yes	5	9	9
271	B:B:D83	B:B:T86	8.67	No	No	7	8	6
272	B:B:S84	B:B:Y85	6.36	No	Yes	11	5	4
273	B:B:S84	G:G:F61	5.28	No	Yes	11	5	8
274	B:B:Y85	G:G:P60	9.74	Yes	No	0	4	9
275	B:B:Y85	G:G:F61	16.5	Yes	Yes	11	4	8
276	B:B:N88	B:B:T86	7.31	No	No	7	7	6
277	B:B:H91	B:B:V90	5.54	No	No	0	5	5
278	B:B:I93	B:B:P94	3.39	Yes	No	0	7	5
279	B:B:I93	B:B:Y124	10.88	Yes	Yes	0	7	6
280	B:B:I93	B:B:V133	6.14	Yes	No	0	7	4
281	B:B:L95	B:B:V100	4.47	Yes	No	0	8	9
282	B:B:C114	B:B:L95	3.17	No	Yes	6	8	8
283	B:B:L95	B:B:Y124	4.69	Yes	Yes	6	8	6
284	B:B:D118	B:B:S97	10.31	No	No	0	9	8
285	B:B:S98	B:B:W99	6.18	No	Yes	1	8	9
286	B:B:L117	B:B:W99	3.42	Yes	Yes	1	9	9
287	B:B:G116	B:B:V100	3.68	No	No	0	9	9
288	B:B:C149	B:B:T102	3.38	No	No	0	8	8
289	B:B:G109	B:B:Y105	5.79	No	Yes	0	5	6
290	B:B:V112	B:B:Y105	3.79	Yes	Yes	6	8	6
291	B:B:L126	B:B:Y105	3.52	No	Yes	0	5	6
292	B:B:F151	B:B:P107	4.33	Yes	No	0	9	6
293	B:B:N110	B:B:S108	7.45	No	No	0	4	6
294	B:B:D154	B:B:S108	8.83	No	No	0	6	6
295	B:B:N110	B:B:Y111	3.49	No	Yes	0	4	4
296	B:B:K127	B:B:N110	6.99	No	No	0	4	4
297	B:B:N125	B:B:Y111	11.63	No	Yes	0	4	4
298	B:B:D154	B:B:Y111	8.05	No	Yes	0	6	4
299	B:B:V112	B:B:Y124	3.79	Yes	Yes	6	8	6
300	B:B:C114	B:B:S122	3.44	No	No	0	8	8
301	B:B:C114	B:B:Y124	5.38	No	Yes	6	8	6
302	B:B:G115	B:B:L146	5.13	No	No	0	9	7
303	B:B:D118	B:B:G116	3.35	No	No	0	9	9
304	B:B:L117	B:B:Y145	3.52	Yes	Yes	1	9	8
305	B:B:D118	B:B:I120	7	No	No	0	9	6
306	B:B:I120	B:B:S122	3.1	No	No	0	6	8
307	B:B:C121	B:B:L139	3.17	No	No	0	8	9
308	B:B:C121	B:B:T159	3.38	No	Yes	0	8	9
309	B:B:I123	B:B:S136	3.1	No	No	0	6	4
310	B:B:I123	B:B:I171	4.42	No	No	0	6	6
311	B:B:V135	B:B:Y124	3.79	No	Yes	0	4	6
312	B:B:K127	B:B:N125	6.99	No	No	0	4	4
313	B:B:N125	B:B:T128	4.39	No	No	0	4	3
314	B:B:E130	B:B:G131	3.27	No	No	0	3	4
315	B:B:G174	B:B:R137	3	No	No	0	4	5
316	B:B:L139	B:B:W169	17.08	No	Yes	0	9	8
317	B:B:H142	B:B:S161	13.95	No	No	1	9	9
318	B:B:D163	B:B:H142	7.56	No	No	0	9	9
319	B:B:H142	B:B:T165	8.21	No	No	1	9	7
320	B:B:D163	B:B:T143	11.56	No	No	0	9	5
321	B:B:D163	B:B:G144	3.35	No	No	0	9	8
322	B:B:G162	B:B:Y145	5.79	No	Yes	1	9	8
323	B:B:D186	B:B:Y145	11.49	Yes	Yes	1	9	8
324	B:B:C149	B:B:L146	3.17	No	No	8	8	7
325	B:B:L146	B:B:T159	4.42	No	Yes	8	7	9
326	B:B:S147	B:B:S160	4.89	No	No	0	9	6
327	B:B:C148	B:B:R150	5.57	No	No	0	6	6
328	B:B:C148	B:B:S189	3.44	No	No	0	6	7
329	B:B:C148	B:B:L190	3.17	No	Yes	0	6	5
330	B:B:C149	B:B:T159	3.38	No	Yes	8	8	9
331	B:B:F151	B:B:I157	10.05	Yes	No	0	9	7
332	B:B:L152	B:B:Q156	5.32	No	No	0	3	5
333	B:B:D153	B:B:N155	4.04	No	No	0	5	3
334	B:B:D153	B:B:Q156	6.53	No	No	0	5	5
335	B:B:E172	B:B:N155	5.26	No	No	0	6	3
336	B:B:I157	B:B:W169	4.7	No	Yes	0	7	8
337	B:B:I157	B:B:I171	4.42	No	No	0	7	6
338	B:B:L190	B:B:V158	2.98	Yes	No	0	5	5
339	B:B:T159	B:B:W169	8.49	Yes	Yes	8	9	8
340	B:B:S160	B:B:V187	3.23	No	No	0	6	9
341	B:B:L190	B:B:S160	3	Yes	No	0	5	6
342	B:B:G162	B:B:S161	3.71	No	No	1	9	9
343	B:B:S161	B:B:T165	4.8	No	No	1	9	7
344	B:B:D186	B:B:G162	5.03	Yes	No	1	9	9
345	B:B:T165	B:B:T179	3.14	No	No	0	7	4
346	B:B:C166	B:B:F180	4.19	No	Yes	4	8	7
347	B:B:C166	B:B:F199	5.59	No	Yes	4	8	9
348	B:B:C166	B:B:S201	3.44	No	No	0	8	9
349	B:B:A167	B:B:W169	3.89	No	Yes	8	4	8
350	B:B:A167	B:B:Q176	6.06	No	No	8	4	4
351	B:B:L168	B:B:T177	4.42	No	No	0	6	4
352	B:B:L168	B:B:T178	2.95	No	No	0	6	4
353	B:B:Q176	B:B:W169	12.05	No	Yes	8	4	8
354	B:B:D170	B:B:E172	7.8	No	No	21	9	6
355	B:B:D170	B:B:T173	14.45	No	Yes	21	9	5
356	B:B:D170	B:B:T177	5.78	No	No	0	9	4
357	B:B:E172	B:B:T173	9.88	No	Yes	21	6	5
358	B:B:G174	B:B:T173	3.64	No	Yes	0	4	5
359	B:B:Q176	B:B:T179	9.92	No	No	0	4	4
360	B:B:F180	B:B:T178	3.89	Yes	No	0	7	4
361	B:B:F180	B:B:F199	9.65	Yes	Yes	4	7	9
362	B:B:F180	B:B:W211	12.03	Yes	Yes	4	7	8
363	B:B:F180	B:B:G216	3.01	Yes	No	0	7	4
364	B:B:H183	B:B:V187	8.3	Yes	No	0	9	9
365	B:B:A203	B:B:H183	7.32	No	Yes	0	8	9
366	B:B:H183	B:B:K209	15.72	Yes	Yes	0	9	6
367	B:B:D205	B:B:T184	11.56	No	No	0	9	3
368	B:B:C204	B:B:G185	3.92	Yes	No	0	7	5
369	B:B:C204	B:B:D186	4.67	Yes	Yes	1	7	9
370	B:B:S201	B:B:V187	3.23	No	No	0	9	9
371	B:B:F199	B:B:L190	6.09	Yes	Yes	0	9	5
372	B:B:I232	B:B:S191	3.1	No	No	0	8	8
373	B:B:F234	B:B:S191	5.28	Yes	No	0	5	8
374	B:B:F199	B:B:L192	3.65	Yes	No	0	9	5
375	B:B:A193	B:B:D195	3.09	No	No	0	4	5
376	B:B:A193	B:B:L198	3.15	No	No	0	4	3
377	B:B:F234	B:B:P194	4.33	Yes	No	2	5	4
378	B:B:G238	B:B:P194	4.06	No	No	2	7	4
379	B:B:D195	B:B:R197	3.57	No	Yes	0	5	5
380	B:B:D212	B:B:R197	3.57	No	Yes	0	9	5
381	B:B:R197	B:B:V213	5.23	Yes	No	0	5	4
382	B:B:R197	B:B:R214	12.79	Yes	No	0	5	9
383	B:B:L198	B:B:L210	5.54	No	No	0	3	5
384	B:B:F199	B:B:W211	13.03	Yes	Yes	4	9	8
385	B:B:F234	B:B:V200	3.93	Yes	No	2	5	6
386	B:B:F241	B:B:V200	13.11	Yes	No	2	6	6
387	B:B:S201	B:B:W211	6.18	No	Yes	0	9	8
388	B:B:G202	B:B:I229	3.53	No	No	0	6	7
389	B:B:D205	B:B:S207	5.89	No	No	0	9	5
390	B:B:K209	B:B:W211	8.12	Yes	Yes	4	6	8
391	B:B:C218	B:B:K209	9.7	Yes	Yes	4	5	6
392	B:B:K209	B:B:T221	13.51	Yes	No	4	6	7
393	B:B:D212	B:B:E215	16.89	No	No	22	9	3
394	B:B:D212	B:B:R219	7.15	No	No	22	9	5
395	B:B:E215	B:B:R219	3.49	No	No	22	3	5
396	B:B:M217	G:G:Q18	6.8	No	No	4	3	9
397	B:B:M217	G:G:M21	4.33	No	No	4	3	1
398	B:B:C218	B:B:T221	3.38	Yes	No	4	5	7
399	B:B:C218	G:G:E22	3.04	Yes	No	4	5	9
400	B:B:F222	B:B:Q220	7.03	Yes	No	2	8	7
401	B:B:D258	B:B:Q220	5.22	Yes	No	2	7	7
402	B:B:T221	G:G:E22	8.47	No	No	4	7	9
403	B:B:F222	B:B:F241	6.43	Yes	Yes	2	8	6
404	B:B:F222	B:B:F253	9.65	Yes	Yes	2	8	6
405	B:B:D258	B:B:F222	4.78	Yes	Yes	2	7	8
406	B:B:E260	B:B:G224	3.27	No	No	0	6	6
407	B:B:H225	B:B:I229	9.28	Yes	No	0	9	7
408	B:B:H225	B:B:T243	10.95	Yes	No	2	9	8
409	B:B:H225	B:B:S245	9.76	Yes	No	2	9	9
410	B:B:H225	B:B:R251	5.64	Yes	No	2	9	8
411	B:B:F253	B:B:H225	4.53	Yes	Yes	2	6	9
412	B:B:D247	B:B:E226	7.8	No	No	0	9	3
413	B:B:D228	B:B:S227	5.89	Yes	No	1	9	6
414	B:B:D246	B:B:S227	5.89	No	No	1	9	6
415	B:B:D228	B:B:D246	7.98	Yes	No	1	9	9
416	B:B:I232	B:B:T243	4.56	No	No	0	8	8
417	B:B:C233	B:B:S277	6.89	No	No	0	3	5
418	B:B:F234	B:B:G238	4.52	Yes	No	2	5	7
419	B:B:F234	B:B:F241	3.22	Yes	Yes	2	5	6
420	B:B:F235	B:B:P236	10.11	Yes	No	2	6	7
421	B:B:F235	B:B:N237	12.08	Yes	Yes	2	6	5
422	B:B:F235	B:B:F278	10.72	Yes	Yes	2	6	7
423	B:B:F235	B:B:G282	4.52	Yes	No	2	6	9
424	B:B:F235	G:G:L37	3.65	Yes	No	2	6	7
425	B:B:F235	G:G:Y40	5.16	Yes	No	2	6	6
426	B:B:F278	B:B:P236	5.78	Yes	No	2	7	7
427	B:B:G282	B:B:P236	4.06	No	No	2	9	7
428	B:B:G238	B:B:N237	3.39	No	Yes	2	7	5
429	B:B:N237	B:B:N239	13.62	Yes	No	0	5	2
430	B:B:N237	G:G:L37	4.12	Yes	No	2	5	7
431	B:B:N237	G:G:Y40	13.96	Yes	No	2	5	6
432	B:B:N239	B:B:R256	4.82	No	Yes	0	2	9
433	B:B:A240	G:G:L37	3.15	No	No	0	6	7
434	B:B:F241	B:B:F253	7.5	Yes	Yes	2	6	6
435	B:B:F241	B:B:L255	3.65	Yes	No	0	6	6
436	B:B:A242	B:B:L285	3.15	No	Yes	0	4	6
437	B:B:F253	B:B:T243	7.78	Yes	No	2	6	8
438	B:B:G244	B:B:I273	5.29	No	No	0	5	6
439	B:B:D247	B:B:S245	8.83	No	No	2	9	9
440	B:B:S245	B:B:T249	3.2	No	Yes	2	9	6
441	B:B:D247	B:B:T249	14.45	No	Yes	2	9	6
442	B:B:A248	B:B:I269	3.25	No	Yes	0	5	4
443	B:B:T249	B:B:T263	3.14	Yes	No	2	6	1
444	B:B:S265	B:B:T249	4.8	No	Yes	2	2	6
445	B:B:C250	B:B:Y264	4.03	No	Yes	2	8	5
446	B:B:C250	B:B:L285	3.17	No	Yes	2	8	6
447	B:B:F253	B:B:R251	4.28	Yes	No	2	6	8
448	B:B:R251	B:B:T263	14.23	No	No	2	8	1
449	B:B:L252	B:B:Y264	3.52	No	Yes	0	7	5
450	B:B:E260	B:B:F253	7	No	Yes	0	6	6
451	B:B:D254	B:B:R256	3.57	No	Yes	0	9	9
452	B:B:A257	B:B:D254	4.63	No	No	0	7	9
453	B:B:D254	G:G:A33	4.63	No	No	0	9	7
454	B:B:R256	G:G:I28	8.77	Yes	No	0	9	4
455	B:B:R256	G:G:D36	5.96	Yes	No	0	9	5
456	B:B:D258	G:G:R27	10.72	Yes	Yes	0	7	8
457	B:B:Q259	G:G:V30	4.3	No	No	0	6	8
458	B:B:M262	B:B:Y264	5.99	Yes	Yes	0	4	5
459	B:B:A302	B:B:M262	3.22	No	Yes	0	2	4
460	B:B:S265	B:B:T263	3.2	No	No	2	2	1
461	B:B:L285	B:B:Y264	3.52	Yes	Yes	2	6	5
462	B:B:W297	B:B:Y264	13.5	Yes	Yes	2	8	5
463	B:B:H266	B:B:I269	5.3	Yes	Yes	2	4	4
464	B:B:H266	B:B:W297	5.29	Yes	Yes	2	4	8
465	B:B:H266	B:B:R304	11.28	Yes	No	2	4	5
466	B:B:D267	B:B:N268	8.08	No	No	0	3	4
467	B:B:I269	B:B:Y289	9.67	Yes	Yes	2	4	7
468	B:B:I269	B:B:R304	5.01	Yes	No	2	4	5
469	B:B:C271	B:B:Y289	4.03	No	Yes	0	5	7
470	B:B:C271	B:B:D290	3.11	No	Yes	0	5	6
471	B:B:C271	B:B:D291	10.89	No	No	0	5	8
472	B:B:I273	B:B:Y289	7.25	No	Yes	0	6	7
473	B:B:R314	B:B:T274	6.47	Yes	No	0	8	8
474	B:B:L318	B:B:S275	4.5	Yes	No	0	6	8
475	B:B:L285	B:B:V276	2.98	Yes	No	0	6	6
476	B:B:L318	B:B:S277	3	Yes	No	0	6	5
477	B:B:F278	B:B:G282	4.52	Yes	No	2	7	9
478	B:B:F278	B:B:L285	4.87	Yes	Yes	2	7	6
479	B:B:L284	B:B:S279	4.5	No	No	0	5	9
480	B:B:S279	G:G:D48	8.83	No	Yes	0	9	9
481	B:B:G324	B:B:K280	3.49	No	Yes	0	9	1
482	B:B:K280	G:G:H44	3.93	Yes	Yes	2	1	6
483	B:B:K280	G:G:E47	6.75	Yes	No	2	1	3
484	B:B:K280	G:G:D48	4.15	Yes	Yes	0	1	9
485	B:B:S281	G:G:D48	8.83	No	Yes	0	9	9
486	B:B:D298	B:B:R283	15.48	No	No	0	9	9
487	B:B:L300	B:B:R283	3.64	Yes	No	0	6	9
488	B:B:L284	B:B:V296	4.47	No	Yes	0	5	5
489	B:B:L286	B:B:V296	4.47	No	Yes	0	7	5
490	B:B:L286	B:B:L318	4.15	No	Yes	0	7	6
491	B:B:L286	B:B:V327	4.47	No	No	0	7	6
492	B:B:N295	B:B:Y289	6.98	Yes	Yes	2	6	7
493	B:B:W297	B:B:Y289	3.86	Yes	Yes	2	8	7
494	B:B:D290	B:B:R314	15.48	Yes	Yes	1	6	8
495	B:B:D291	B:B:N293	4.04	No	No	0	8	5
496	B:B:F292	B:B:N313	4.83	No	No	0	4	7
497	B:B:C294	B:B:L308	4.76	No	No	0	5	7
498	B:B:N295	B:B:W297	3.39	Yes	Yes	2	6	8
499	B:B:N295	B:B:R304	8.44	Yes	No	2	6	5
500	B:B:N295	B:B:V307	4.43	Yes	No	0	6	3
501	B:B:A305	B:B:V296	3.39	No	Yes	0	4	5
502	B:B:G306	B:B:V296	3.68	No	Yes	0	4	5
503	B:B:D298	B:B:K301	6.91	No	No	0	9	5
504	B:B:L300	G:G:C41	3.17	Yes	No	0	6	7
505	B:B:V307	R:R:I411	3.07	No	No	0	3	4
506	B:B:L308	B:B:W339	23.92	No	No	0	7	9
507	B:B:G310	B:B:K337	3.49	No	Yes	0	5	6
508	B:B:H311	B:B:T329	8.21	Yes	No	0	9	8
509	B:B:H311	B:B:S331	12.55	Yes	No	23	9	9
510	B:B:D333	B:B:H311	6.3	No	Yes	23	9	9
511	B:B:H311	B:B:K337	3.93	Yes	Yes	0	9	6
512	B:B:D312	B:B:D333	5.32	No	No	0	5	9
513	B:B:D312	R:R:R404	10.72	No	No	0	5	7
514	B:B:N313	B:B:R314	3.62	No	Yes	1	7	8
515	B:B:N313	B:B:W332	4.52	No	Yes	1	7	9
516	B:B:R314	B:B:W332	23.99	Yes	Yes	1	8	9
517	B:B:S316	B:B:W332	9.88	No	Yes	0	9	9
518	B:B:L318	B:B:T329	2.95	Yes	No	0	6	8
519	B:B:V320	B:B:V327	8.02	No	No	0	7	6
520	B:B:D323	B:B:T321	5.78	No	No	20	7	7
521	B:B:D323	B:B:M325	5.54	No	Yes	0	7	5
522	B:B:M325	G:G:P49	3.35	Yes	No	0	5	7
523	B:B:M325	G:G:P60	6.71	Yes	No	0	5	9
524	B:B:M325	G:G:F61	4.98	Yes	Yes	0	5	8
525	B:B:A326	G:G:F61	8.32	No	Yes	0	7	8
526	B:B:V327	G:G:L50	4.47	No	No	0	6	9
527	B:B:A328	B:B:I338	3.25	No	No	0	5	5
528	B:B:T329	B:B:W339	6.06	No	No	0	8	9
529	B:B:D333	B:B:S331	10.31	No	No	23	9	9
530	B:B:F335	B:B:S334	7.93	No	No	0	4	4
531	B:B:I338	G:G:F61	3.77	No	Yes	11	5	8
532	B:B:N340	G:G:N59	10.9	No	No	0	9	9
533	B:B:N340	G:G:F61	6.04	No	Yes	0	9	8
534	G:G:Q11	G:G:S8	4.33	No	No	0	3	4
535	G:G:A12	G:G:Q11	3.03	No	No	0	5	3
536	G:G:M21	G:G:Q18	4.08	No	No	4	1	9
537	G:G:I25	G:G:R27	12.53	No	Yes	0	2	8
538	G:G:I28	G:G:K32	7.27	No	No	0	4	5
539	G:G:D36	G:G:K32	4.15	No	No	0	5	5
540	G:G:E42	G:G:M38	5.41	No	No	0	1	4
541	G:G:H44	G:G:Y40	7.62	Yes	No	2	6	6
542	G:G:A43	G:G:H44	4.39	No	Yes	0	4	6
543	G:G:E47	G:G:H44	3.69	No	Yes	2	3	6
544	G:G:D48	G:G:P49	4.83	Yes	No	0	9	7
545	G:G:D48	G:G:L50	4.07	Yes	No	0	9	9
546	G:G:D48	G:G:L51	4.07	Yes	Yes	0	9	6
547	G:G:L51	G:G:T52	2.95	Yes	No	0	6	4
548	G:G:P53	G:G:T52	3.5	No	No	0	8	4
549	G:G:P55	G:G:V54	3.53	No	No	24	5	6
550	G:G:E58	G:G:V54	4.28	No	No	24	5	6
551	G:G:N59	G:G:V54	4.43	No	No	0	9	6
552	G:G:E58	G:G:P55	12.58	No	No	24	5	5
553	G:G:E58	G:G:S57	7.19	No	No	0	5	6
554	G:G:N59	G:G:P60	6.52	No	No	0	9	9
555	R:R:P139	R:R:T138	3.5	No	No	0	3	2
556	R:R:E140	R:R:N144	3.94	Yes	No	0	2	4
557	R:R:E140	R:R:K366	8.1	Yes	No	25	2	3
558	R:R:E140	R:R:K370	8.1	Yes	No	25	2	4
559	R:R:L142	R:R:Y146	4.69	No	No	0	2	2
560	R:R:N144	R:R:Y374	8.14	No	No	0	4	6
561	R:R:H377	R:R:L148	12.86	No	No	0	7	5
562	R:R:I153	R:R:Y149	4.84	No	Yes	0	7	5
563	R:R:L202	R:R:Y149	7.03	No	Yes	0	7	5
564	R:R:F382	R:R:L151	3.65	Yes	No	0	7	5
565	R:R:F382	R:R:G155	9.03	Yes	No	0	7	8
566	R:R:H156	R:R:S195	8.37	Yes	No	0	7	7
567	R:R:H156	R:R:I198	10.61	Yes	No	0	7	7
568	R:R:H156	R:R:H381	8.36	Yes	Yes	0	7	9
569	R:R:F385	R:R:L158	4.87	Yes	No	0	5	4
570	R:R:I160	R:R:I192	4.42	No	No	0	5	7
571	R:R:I160	R:R:S195	6.19	No	No	0	5	7
572	R:R:F161	R:R:I165	7.54	No	No	0	4	5
573	R:R:F385	R:R:T162	10.38	Yes	No	0	5	6
574	R:R:F188	R:R:L163	8.53	Yes	No	0	8	8
575	R:R:L163	R:R:Y191	4.69	No	Yes	0	8	8
576	R:R:A388	R:R:L163	4.73	No	No	0	8	8
577	R:R:F188	R:R:S166	5.28	Yes	No	0	8	9
578	R:R:C392	R:R:S166	6.89	No	No	0	9	9
579	R:R:F188	R:R:L167	6.09	Yes	No	0	8	6
580	R:R:F170	R:R:I169	3.77	Yes	No	12	8	8
581	R:R:C392	R:R:I169	3.27	No	No	12	9	8
582	R:R:F170	R:R:L176	10.96	Yes	Yes	12	8	9
583	R:R:F170	R:R:V181	5.24	Yes	Yes	12	8	9
584	R:R:F170	R:R:F188	3.22	Yes	Yes	0	8	8
585	R:R:C392	R:R:F170	6.98	No	Yes	12	9	8
586	R:R:K185	R:R:V171	3.04	No	No	0	6	4
587	R:R:F172	R:R:F173	8.57	No	Yes	0	2	7
588	R:R:F173	R:R:T401	6.49	Yes	No	0	7	7
589	R:R:L176	R:R:V181	4.47	Yes	Yes	12	9	9
590	R:R:E397	R:R:L176	13.25	No	Yes	0	9	9
591	R:R:L176	R:R:V398	5.96	Yes	No	0	9	9
592	R:R:G177	R:R:V181	5.52	No	Yes	0	7	9
593	R:R:C178	R:R:V181	3.42	No	Yes	0	8	9
594	R:R:Q179	R:R:Y243	4.51	Yes	Yes	0	7	8
595	R:R:Q179	R:R:Q257	3.84	Yes	No	26	7	5
596	R:R:L259	R:R:Q179	10.65	Yes	Yes	26	5	7
597	R:R:H184	R:R:R180	6.77	No	No	0	9	9
598	R:R:L183	R:R:Y243	7.03	No	Yes	0	8	8
599	R:R:L183	R:R:L259	5.54	No	Yes	0	8	5
600	R:R:E240	R:R:H184	8.62	No	No	0	9	9
601	R:R:N186	R:R:W236	9.04	No	Yes	0	9	9
602	R:R:N186	R:R:Y263	6.98	No	No	0	9	5
603	R:R:M187	R:R:T190	3.01	Yes	No	0	8	9
604	R:R:M187	R:R:Y191	7.18	Yes	Yes	0	8	8
605	R:R:M187	R:R:W236	3.49	Yes	Yes	0	8	9
606	R:R:E240	R:R:M187	5.41	No	Yes	0	9	8
607	R:R:L189	R:R:L193	4.15	No	No	0	3	6
608	R:R:N233	R:R:T190	7.31	No	No	0	9	9
609	R:R:N233	R:R:Y191	12.79	No	Yes	0	9	8
610	R:R:Q383	R:R:Y191	4.51	No	Yes	0	9	8
611	R:R:V387	R:R:Y191	5.05	No	Yes	0	9	8
612	R:R:L193	R:R:M229	8.48	No	No	0	6	4
613	R:R:N194	R:R:N233	5.45	No	No	0	8	9
614	R:R:H226	R:R:I197	3.98	Yes	No	0	6	5
615	R:R:H226	R:R:I198	6.63	Yes	No	0	6	7
616	R:R:E204	R:R:I200	8.2	No	No	0	4	6
617	R:R:H201	R:R:V205	4.15	No	No	0	6	7
618	R:R:D215	R:R:P216	8.05	No	No	0	6	4
619	R:R:D215	R:R:V217	7.3	No	No	0	6	3
620	R:R:D215	R:R:S218	5.89	No	No	0	6	3
621	R:R:C219	R:R:C289	7.28	No	No	0	9	9
622	R:R:A282	R:R:K220	3.21	No	No	27	3	7
623	R:R:K220	R:R:N288	20.98	No	No	27	7	4
624	R:R:H223	R:R:Q227	4.95	No	No	0	5	7
625	R:R:F224	R:R:T274	7.78	No	No	0	5	6
626	R:R:A278	R:R:F224	5.55	No	No	0	6	5
627	R:R:H226	R:R:Q227	4.95	Yes	No	0	6	7
628	R:R:H226	R:R:M230	3.94	Yes	No	0	6	6
629	R:R:I301	R:R:Q227	4.12	No	No	0	7	7
630	R:R:L271	R:R:Y228	5.86	No	No	28	4	8
631	R:R:T274	R:R:Y228	6.24	No	No	28	6	8
632	R:R:C232	R:R:W267	7.84	No	No	0	8	9
633	R:R:C232	R:R:P270	3.77	No	No	0	8	9
634	R:R:V305	R:R:Y234	3.79	No	No	0	7	7
635	R:R:L309	R:R:Y234	4.69	No	No	29	7	7
636	R:R:F356	R:R:Y234	8.25	Yes	No	29	7	7
637	R:R:F235	R:R:F269	5.36	Yes	No	0	5	3
638	R:R:F235	R:R:P270	4.33	Yes	No	0	5	9
639	R:R:C239	R:R:W236	9.14	No	Yes	0	7	9
640	R:R:A308	R:R:L238	4.73	No	No	0	7	8
641	R:R:C239	R:R:Y262	5.38	No	Yes	0	7	7
642	R:R:C239	R:R:L265	3.17	No	No	0	7	7
643	R:R:G241	R:R:N312	3.39	No	Yes	0	8	9
644	R:R:I242	R:R:Y262	4.84	No	Yes	0	7	7
645	R:R:F315	R:R:I242	3.77	Yes	No	0	8	7
646	R:R:Y243	R:R:Y262	4.96	Yes	Yes	0	8	7
647	R:R:I319	R:R:L244	4.28	No	No	0	9	9
648	R:R:H245	R:R:V249	6.92	Yes	No	0	8	6
649	R:R:F315	R:R:H245	6.79	Yes	Yes	0	8	8
650	R:R:H245	R:R:N318	6.38	Yes	No	0	8	8
651	R:R:H245	R:R:I319	6.63	Yes	No	0	8	9
652	R:R:T246	R:R:Y262	3.75	No	Yes	0	7	7
653	R:R:I248	R:R:I319	4.42	No	No	0	7	9
654	R:R:E255	R:R:F253	12.83	No	No	0	6	6
655	R:R:L259	R:R:Q257	6.65	Yes	No	26	5	5
656	R:R:L259	R:R:Y263	14.07	Yes	No	0	5	5
657	R:R:L264	R:R:R260	8.5	No	No	0	3	3
658	R:R:L271	R:R:T274	4.42	No	No	28	4	6
659	R:R:L271	R:R:T275	2.95	No	No	0	4	3
660	R:R:P273	R:R:V272	3.53	No	No	0	6	4
661	R:R:I276	R:R:V272	3.07	No	No	0	5	4
662	R:R:I276	R:R:T280	3.04	No	No	0	5	4
663	R:R:H277	R:R:R281	7.9	Yes	Yes	10	7	7
664	R:R:H277	R:R:L291	3.86	Yes	Yes	10	7	6
665	R:R:H277	R:R:L298	3.86	Yes	No	0	7	6
666	R:R:H277	R:R:I300	6.63	Yes	No	0	7	8
667	R:R:H277	R:R:I301	10.61	Yes	No	0	7	7
668	R:R:R281	R:R:Y284	7.2	Yes	No	0	7	2
669	R:R:N286	R:R:R281	3.62	No	Yes	10	7	7
670	R:R:L291	R:R:R281	3.64	Yes	Yes	10	6	7
671	R:R:E294	R:R:R281	13.96	No	Yes	10	3	7
672	R:R:L297	R:R:R281	9.72	No	Yes	10	4	7
673	R:R:A282	R:R:N288	3.13	No	No	27	3	4
674	R:R:F285	R:R:N288	9.67	No	No	0	6	4
675	R:R:D287	R:R:N286	6.73	No	No	0	3	7
676	R:R:L291	R:R:N286	4.12	Yes	No	10	6	7
677	R:R:D287	R:R:W290	5.58	No	No	0	3	9
678	R:R:C289	R:R:W290	18.28	No	No	0	9	9
679	R:R:S292	R:R:W290	4.94	No	No	0	4	9
680	R:R:E294	R:R:L291	5.3	No	Yes	10	3	6
681	R:R:E294	R:R:L297	6.63	No	No	10	3	4
682	R:R:H296	R:R:T295	4.11	No	No	0	2	4
683	R:R:H302	R:R:L298	7.71	No	No	0	6	6
684	R:R:G303	R:R:Y299	4.35	No	No	0	4	7
685	R:R:H302	R:R:I301	9.28	No	No	0	6	7
686	R:R:G303	R:R:P304	4.06	No	No	0	4	9
687	R:R:F356	R:R:L309	4.87	Yes	No	29	7	7
688	R:R:V310	R:R:V357	3.21	No	No	0	4	7
689	R:R:F314	R:R:V311	3.93	No	No	31	5	6
690	R:R:F315	R:R:V311	5.24	Yes	No	31	8	6
691	R:R:L352	R:R:N312	9.61	No	Yes	30	9	9
692	R:R:I354	R:R:N312	5.66	Yes	Yes	30	6	9
693	R:R:F313	R:R:L317	9.74	Yes	No	0	6	5
694	R:R:F313	R:R:I354	3.77	Yes	Yes	0	6	6
695	R:R:F313	R:R:V357	9.18	Yes	No	0	6	7
696	R:R:F313	R:R:V358	3.93	Yes	No	0	6	5
697	R:R:F314	R:R:F315	6.43	No	Yes	31	5	8
698	R:R:L316	R:R:V349	7.45	No	No	0	9	8
699	R:R:I354	R:R:L316	5.71	Yes	No	0	6	9
700	R:R:N318	R:R:R321	3.62	No	No	0	8	8
701	R:R:K326	R:R:V322	3.04	No	No	0	9	8
702	R:R:L323	R:R:M327	5.65	No	Yes	0	9	7
703	R:R:M327	R:R:Y338	7.18	Yes	No	0	7	7
704	R:R:A341	R:R:M327	3.22	No	Yes	0	9	7
705	R:R:T330	R:R:Y338	4.99	No	No	0	5	7
706	R:R:T345	R:R:V342	3.17	No	No	0	9	8
707	R:R:I390	R:R:L348	4.28	No	No	0	8	9
708	R:R:P350	R:R:V349	5.3	No	No	0	9	8
709	R:R:F386	R:R:L351	4.87	No	No	9	5	9
710	R:R:L351	R:R:V387	2.98	No	No	9	9	9
711	R:R:L351	R:R:Y391	3.52	No	Yes	9	9	8
712	R:R:I354	R:R:L352	5.71	Yes	No	30	6	9
713	R:R:F356	R:R:Q355	14.05	Yes	No	0	7	8
714	R:R:L379	R:R:Q355	5.32	No	No	0	5	8
715	R:R:Q355	R:R:Q383	6.4	No	No	0	8	9
716	R:R:F356	R:R:I380	6.28	Yes	No	0	7	6
717	R:R:F359	R:R:P360	4.33	No	No	13	6	5
718	R:R:F359	R:R:Y372	4.13	No	Yes	13	6	7
719	R:R:F359	R:R:M376	3.73	No	No	13	6	7
720	R:R:P360	R:R:Y372	4.17	No	Yes	13	5	7
721	R:R:M376	R:R:P360	3.35	No	No	13	7	5
722	R:R:K366	R:R:K370	4.31	No	No	25	3	4
723	R:R:D373	R:R:Y372	3.45	No	Yes	0	5	7
724	R:R:D373	R:R:H377	3.78	No	No	0	5	7
725	R:R:H377	R:R:H381	8.36	No	Yes	0	7	9
726	R:R:H381	R:R:I380	3.98	Yes	No	0	9	6
727	R:R:F382	R:R:F385	4.29	Yes	Yes	9	7	5
728	R:R:F382	R:R:F386	3.22	Yes	No	9	7	5
729	R:R:F385	R:R:F386	4.29	Yes	No	9	5	5
730	R:R:V387	R:R:Y391	6.31	No	Yes	9	9	8
731	R:R:I390	R:R:Y391	4.84	No	Yes	0	8	8
732	R:R:N395	R:R:V398	5.91	No	No	0	9	9
733	R:R:N396	R:R:Q399	6.6	No	No	0	6	7
734	R:R:E397	R:R:T401	7.06	No	No	0	9	7
735	R:R:R404	R:R:T401	6.47	No	No	0	7	7
736	R:R:K403	R:R:W406	6.96	No	No	0	6	6
737	R:R:K410	R:R:W406	11.6	No	No	0	4	6
738	R:R:F409	R:R:W413	9.02	No	No	0	3	3
739	R:R:Q412	R:R:R416	17.52	No	No	0	4	2
740	R:R:R416	R:R:W413	4	No	No	0	2	3
741	R:R:W413	R:R:W417	14.06	No	No	0	3	2
742	R:R:I276	R:R:I300	2.94	No	No	0	5	8
743	R:R:A152	R:R:H381	2.93	No	Yes	0	7	9
744	A:A:D33	A:A:V36	2.92	No	No	0	5	2
745	A:A:N371	A:A:T364	2.92	No	No	0	9	9
746	R:R:I160	R:R:M196	2.92	No	No	0	5	4
747	R:R:I371	R:R:M367	2.92	No	No	0	5	4
748	R:R:N396	R:R:T400	2.92	No	No	0	6	4
749	R:R:G384	R:R:Y191	2.9	No	Yes	0	9	8
750	R:R:G369	R:R:Y372	2.9	No	Yes	0	4	7
751	B:B:D322	B:B:T65	2.89	No	No	0	1	1
752	R:R:F235	R:R:P304	2.89	Yes	No	0	5	9
753	A:A:Q384	R:R:V249	2.87	Yes	No	0	6	6
754	B:B:E138	B:B:S122	2.87	No	No	0	6	8
755	B:B:V307	R:R:Q415	2.87	No	No	0	3	1
756	A:A:L30	B:B:I80	2.85	No	Yes	0	5	8
757	A:A:I244	A:A:L46	2.85	No	No	0	8	8
758	R:R:I198	R:R:L202	2.85	No	No	0	7	7
759	R:R:I371	R:R:L368	2.85	No	No	0	5	3
760	B:B:L308	B:B:M45	2.83	No	No	0	7	4
761	B:B:Q175	B:B:T173	2.83	No	Yes	0	4	5
762	R:R:Q179	R:R:T182	2.83	Yes	No	0	7	5
763	R:R:K185	R:R:L167	2.82	No	No	0	6	6
764	B:B:G319	B:B:W63	2.81	No	Yes	0	5	7
765	B:B:G141	B:B:W169	2.81	No	Yes	0	5	8
766	R:R:G266	R:R:W236	2.81	No	Yes	0	9	9
767	G:G:K20	G:G:N24	2.8	No	No	0	6	1
768	A:A:H357	A:A:S286	2.79	No	No	0	7	8
769	B:B:C25	G:G:R27	2.79	No	Yes	0	3	8
770	B:B:H183	B:B:S207	2.79	Yes	No	0	9	5
771	A:A:A337	A:A:F315	2.77	No	No	0	8	6
772	A:A:L388	A:A:L393	2.77	No	No	0	8	8
773	B:B:A104	B:B:F151	2.77	No	Yes	0	7	9
774	B:B:A106	B:B:F151	2.77	No	Yes	0	6	9
775	B:B:A113	B:B:F151	2.77	No	Yes	0	9	9
776	B:B:A193	B:B:F234	2.77	No	Yes	0	4	5
777	B:B:A208	B:B:F241	2.77	No	Yes	0	6	6
778	B:B:L210	B:B:L255	2.77	No	No	0	5	6
779	R:R:H245	R:R:V250	2.77	Yes	No	0	8	5
780	R:R:L238	R:R:N312	2.75	No	Yes	0	8	9
781	R:R:M237	R:R:Q383	2.72	No	No	0	9	9
782	A:A:K216	A:A:Q213	2.71	No	No	0	4	3
783	R:R:E255	R:R:K256	2.7	No	No	0	6	5
784	B:B:A106	B:B:Y111	2.67	No	Yes	0	6	4
785	B:B:A287	B:B:Y289	2.67	No	Yes	0	6	7
786	B:B:L14	B:B:Q17	2.66	No	No	0	8	4
787	A:A:E344	A:A:L270	2.65	No	Yes	0	5	6
788	R:R:H156	R:R:I199	2.65	Yes	No	0	7	7
789	R:R:F385	R:R:S159	2.64	Yes	No	0	5	9
790	R:R:F235	R:R:V305	2.62	Yes	No	0	5	7
791	A:A:D310	A:A:E309	2.6	No	No	0	3	4
792	R:R:R404	R:R:T400	2.59	No	No	0	7	4
793	B:B:Q6	B:B:Q9	2.56	No	No	0	1	3
794	R:R:Q405	R:R:Q408	2.56	No	No	0	4	7
795	R:R:V203	R:R:Y149	2.52	No	Yes	0	3	5
796	R:R:V349	R:R:Y391	2.52	No	Yes	0	8	8
797	A:A:F212	A:A:I372	2.51	Yes	No	0	9	8
798	A:A:F290	A:A:I245	2.51	No	Yes	0	9	7
799	R:R:F225	R:R:I221	2.51	No	No	0	5	4
800	A:A:F212	A:A:M221	2.49	Yes	No	0	9	8
801	R:R:M337	R:R:R328	2.48	No	No	0	7	6
802	A:A:F363	A:A:L291	2.44	No	No	0	5	8
803	A:A:N279	A:A:R280	2.41	No	No	0	8	5
804	B:B:N340	B:B:R48	2.41	No	No	0	9	7
805	R:R:M229	R:R:Y228	2.39	No	No	0	4	8
806	R:R:K340	R:R:Y338	2.39	No	No	0	8	7
807	B:B:D5	B:B:R8	2.38	No	No	0	1	3
808	A:A:L346	A:A:Y358	2.34	No	No	0	4	4
809	A:A:L393	A:A:Y391	2.34	No	Yes	0	8	4
810	B:B:Q259	B:B:R22	2.34	No	No	0	6	6
811	R:R:F173	R:R:Q405	2.34	Yes	No	0	7	4
812	A:A:E344	A:A:F340	2.33	No	Yes	0	5	7
813	R:R:L189	R:R:W267	2.28	No	No	0	3	9
814	R:R:N414	R:R:W417	2.26	No	No	0	4	2
815	B:B:R46	B:B:R48	2.13	No	No	0	5	7
816	A:A:G225	A:A:G226	2.11	No	No	0	9	9
817	R:R:R258	R:R:W261	2	No	No	0	5	2
818	R:R:Y149	R:R:Y150	1.99	Yes	No	0	5	4
819	B:B:C294	B:B:G288	1.96	No	No	0	5	7
820	R:R:A231	R:R:P270	1.87	No	No	0	5	9
821	B:B:G330	B:B:S331	1.86	No	No	0	5	9
822	A:A:G47	A:A:V247	1.84	No	No	0	9	7
823	B:B:G41	B:B:V40	1.84	No	No	0	1	3
824	B:B:G288	B:B:V315	1.84	No	No	0	7	7
825	R:R:G155	R:R:V154	1.84	No	No	0	8	6
826	R:R:G168	R:R:V171	1.84	No	No	0	1	4
827	B:B:G131	B:B:T128	1.82	No	No	0	4	3
828	B:B:G182	B:B:T181	1.82	No	No	0	6	2
829	B:B:A73	B:B:C103	1.81	No	No	0	9	8
830	B:B:A60	B:B:A73	1.79	No	No	0	7	9
831	R:R:G353	R:R:I354	1.76	No	Yes	0	9	6
832	B:B:P107	B:B:T65	1.75	No	No	0	6	1
833	B:B:G182	B:B:K209	1.74	No	Yes	0	6	6
834	B:B:A231	B:B:S189	1.71	No	No	0	5	7
835	B:B:A231	B:B:S275	1.71	No	No	0	5	8
836	R:R:G369	R:R:L368	1.71	No	No	0	4	3
837	A:A:A269	A:A:V248	1.7	No	No	0	9	7
838	B:B:G131	B:B:N132	1.7	No	No	0	4	3
839	B:B:D246	B:B:G272	1.68	No	No	0	9	4
840	B:B:D290	B:B:G272	1.68	Yes	No	0	6	4
841	R:R:A251	R:R:T246	1.68	No	No	0	6	7
842	A:A:L346	A:A:P361	1.64	No	No	0	4	5
843	B:B:C25	G:G:K29	1.62	No	No	0	3	4
844	B:B:I33	G:G:A34	1.62	No	No	0	3	6
845	B:B:A140	B:B:I120	1.62	No	No	0	5	6
846	R:R:S292	R:R:V293	1.62	No	No	0	4	6
847	G:G:A10	G:G:K14	1.61	No	No	0	2	4
848	B:B:S31	B:B:T29	1.6	No	No	0	1	3
849	B:B:S207	B:B:T223	1.6	No	No	0	5	2
850	R:R:V320	R:R:V342	1.6	No	No	0	7	8
851	R:R:T325	R:R:V322	1.59	No	No	0	7	8
852	A:A:Q29	B:B:P94	1.58	No	No	0	4	5
853	B:B:L30	G:G:A34	1.58	Yes	No	18	5	6
854	B:B:L261	G:G:A34	1.58	No	No	18	5	6
855	B:B:A299	B:B:L300	1.58	No	Yes	0	5	6
856	G:G:A45	G:G:L51	1.58	No	Yes	0	4	6
857	A:A:A39	A:A:N218	1.56	No	No	0	5	4
858	B:B:A309	B:B:N293	1.56	No	No	0	3	5
859	A:A:I244	A:A:V241	1.54	No	No	15	8	9
860	A:A:I285	A:A:V241	1.54	No	No	15	7	9
861	A:A:I245	A:A:V247	1.54	Yes	No	0	7	7
862	B:B:A28	B:B:D27	1.54	No	No	0	4	8
863	B:B:I43	B:B:V40	1.54	No	No	0	3	3
864	G:G:A39	G:G:D36	1.54	No	No	0	3	5
865	R:R:I192	R:R:V164	1.54	No	No	0	7	4
866	R:R:I221	R:R:V217	1.54	No	No	0	4	3
867	B:B:C218	G:G:Q18	1.53	Yes	No	4	5	9
868	R:R:K143	R:R:V147	1.52	No	No	0	1	4
869	R:R:M337	R:R:V324	1.52	No	No	0	7	5
870	R:R:M376	R:R:V375	1.52	No	No	0	7	4
871	R:R:I390	R:R:T389	1.52	No	No	0	8	5
872	B:B:R42	R:R:G418	1.5	No	No	0	2	1
873	R:R:L158	R:R:S157	1.5	No	No	0	4	7
874	A:A:L291	A:A:V248	1.49	No	No	0	8	7
875	B:B:L7	G:G:V16	1.49	No	No	0	8	7
876	R:R:L339	R:R:V342	1.49	No	No	0	6	8
877	A:A:I235	A:A:I276	1.47	No	No	0	9	8
878	B:B:L152	B:B:T196	1.47	No	No	0	3	1
879	B:B:D312	R:R:S175	1.47	No	No	0	5	8
880	R:R:I197	R:R:I200	1.47	No	No	0	5	6
881	B:B:A206	B:B:H225	1.46	No	Yes	0	4	9
882	A:A:I26	A:A:K25	1.45	No	No	0	9	5
883	A:A:F312	A:A:P313	1.44	No	No	0	8	6
884	R:R:G418	R:R:W417	1.41	No	No	0	1	2
885	A:A:K233	B:B:N230	1.4	Yes	No	1	9	9
886	B:B:M188	B:B:N230	1.4	No	No	1	8	9
887	A:A:D33	B:B:K78	1.38	No	Yes	0	5	8
888	A:A:A351	A:A:R347	1.38	No	No	0	4	4
889	A:A:E21	A:A:K25	1.35	No	No	0	2	5
890	A:A:C237	B:B:Y59	1.34	No	Yes	0	8	8
891	B:B:E10	B:B:L7	1.33	No	No	0	8	8
892	R:R:E204	R:R:L222	1.33	No	No	0	4	6
893	R:R:F382	R:R:S378	1.32	Yes	No	0	7	5
894	A:A:E392	R:R:N395	1.31	No	No	0	6	9
895	A:A:E392	R:R:N396	1.31	No	No	0	6	6
896	R:R:F173	R:R:V402	1.31	Yes	No	0	7	5
897	A:A:F212	A:A:T210	1.3	Yes	No	0	9	7
898	R:R:F161	R:R:T162	1.3	No	No	0	4	6
899	R:R:F393	R:R:T389	1.3	No	No	0	8	5
900	R:R:H201	R:R:L222	1.29	No	No	0	6	6
901	B:B:D267	B:B:H266	1.26	No	Yes	0	3	4
902	R:R:K256	R:R:R258	1.24	No	No	0	5	5
903	B:B:N132	B:B:R134	1.21	No	No	0	3	3
904	R:R:E140	R:R:F137	1.17	Yes	No	0	2	1
905	A:A:E268	A:A:R265	1.16	No	No	0	9	9
906	R:R:H331	R:R:R328	1.13	No	No	0	7	6
907	A:A:Y358	R:R:H331	1.09	No	No	0	4	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	A:A:Q19	9.766	5	7	4
2	A:A:Y37	5.4725	4	1	4
3	A:A:R42	8.42	4	1	9
4	A:A:E209	7.3	4	1	9
5	A:A:F212	3.9875	4	0	9
6	A:A:F219	6.435	4	14	8
7	A:A:H220	8.416	5	1	7
8	A:A:F222	5.455	6	1	7
9	A:A:Q227	5.7	4	1	9
10	A:A:K233	6.862	5	1	9
11	A:A:W234	7.3475	4	0	9
12	A:A:F238	9.79	4	1	9
13	A:A:I245	3.1525	4	0	7
14	A:A:F246	6.345	4	3	9
15	A:A:L270	5.775	4	0	6
16	A:A:F273	6.71714	7	3	9
17	A:A:W277	11.682	5	3	6
18	A:A:W281	8.96	4	1	5
19	A:A:V287	5.4475	4	3	6
20	A:A:Y318	8.8425	4	0	6
21	A:A:F340	6.14	4	0	7
22	A:A:D354	6.986	5	3	3
23	A:A:Y360	7.958	5	16	8
24	A:A:F376	6.72	4	14	8
25	A:A:I383	4.5675	4	0	8
26	A:A:Q384	6.68	4	17	6
27	A:A:H387	5.265	4	0	8
28	A:A:Y391	6.6475	4	0	4
29	B:B:I18	4.075	4	0	7
30	B:B:L30	5.005	4	18	5
31	B:B:L51	7.715	4	5	9
32	B:B:H54	9.336	5	5	9
33	B:B:K57	6.742	5	1	9
34	B:B:Y59	5.2475	4	1	8
35	B:B:W63	6.4175	4	0	7
36	B:B:R68	9.065	4	0	5
37	B:B:Q75	6.75333	6	1	9
38	B:B:D76	7.4675	4	1	9
39	B:B:K78	5.7325	4	0	8
40	B:B:L79	5.46	4	0	7
41	B:B:I80	7.135	4	5	8
42	B:B:W82	9.96	6	5	9
43	B:B:Y85	11.2375	4	11	4
44	B:B:K89	6.5025	4	5	9
45	B:B:I93	7.2425	4	0	7
46	B:B:L95	4.6	5	6	8
47	B:B:W99	6.27857	7	1	9
48	B:B:Y105	4.295	6	6	6
49	B:B:Y111	6.46	4	0	4
50	B:B:V112	3.368	5	6	8
51	B:B:L117	3.95	4	1	9
52	B:B:Y124	5.706	5	6	6
53	B:B:Y145	6.61	4	1	8
54	B:B:F151	4.538	5	0	9
55	B:B:T159	4.9175	4	8	9
56	B:B:W169	8.17	6	8	8
57	B:B:T173	7.7	4	21	5
58	B:B:F180	6.554	5	4	7
59	B:B:H183	8.5325	4	0	9
60	B:B:D186	6.35833	6	1	9
61	B:B:L190	3.81	4	0	5
62	B:B:R197	6.29	4	0	5
63	B:B:F199	7.602	5	4	9
64	B:B:C204	5.1	4	1	7
65	B:B:K209	9.758	5	4	6
66	B:B:W211	9.84	4	4	8
67	B:B:C218	4.4125	4	4	5
68	B:B:F222	6.9725	4	2	8
69	B:B:H225	6.93667	6	2	9
70	B:B:D228	7.9725	4	1	9
71	B:B:F234	4.00833	6	2	5
72	B:B:F235	7.70667	6	2	6
73	B:B:N237	9.434	5	2	5
74	B:B:F241	6.11333	6	2	6
75	B:B:T249	6.3975	4	2	6
76	B:B:F253	6.79	6	2	6
77	B:B:R256	5.78	4	0	9
78	B:B:D258	6.0725	4	2	7
79	B:B:M262	4.5125	4	0	4
80	B:B:Y264	6.112	5	2	5
81	B:B:H266	5.7825	4	2	4
82	B:B:I269	5.8075	4	2	4
83	B:B:F278	6.4725	4	2	7
84	B:B:K280	4.58	4	2	1
85	B:B:L285	3.538	5	2	6
86	B:B:Y289	5.74333	6	2	7
87	B:B:D290	6.185	4	1	6
88	B:B:N295	5.81	4	2	6
89	B:B:V296	4.0025	4	0	5
90	B:B:W297	6.51	4	2	8
91	B:B:L300	4.3075	4	0	6
92	B:B:H311	7.7475	4	23	9
93	B:B:R314	12.512	5	1	8
94	B:B:L318	3.65	4	0	6
95	B:B:M325	5.145	4	0	5
96	B:B:W332	11.19	6	1	9
97	B:B:K337	7.86	4	0	6
98	G:G:R27	7.066	5	0	8
99	G:G:H44	4.9075	4	2	6
100	G:G:D48	5.79667	6	0	9
101	G:G:L51	2.895	4	0	6
102	G:G:F61	7.17571	7	11	8
103	R:R:E140	5.3275	4	25	2
104	R:R:Y149	4.095	4	0	5
105	R:R:H156	7.4975	4	0	7
106	R:R:F170	6.034	5	12	8
107	R:R:F173	4.6775	4	0	7
108	R:R:L176	8.66	4	12	9
109	R:R:Q179	5.4575	4	26	7
110	R:R:V181	4.6625	4	12	9
111	R:R:M187	4.7725	4	0	8
112	R:R:F188	5.78	4	0	8
113	R:R:Y191	6.18667	6	0	8
114	R:R:H226	4.875	4	0	6
115	R:R:F235	3.8	4	0	5
116	R:R:W236	6.12	4	0	9
117	R:R:Y243	4.87	4	0	8
118	R:R:H245	5.898	5	0	8
119	R:R:L259	9.2275	4	26	5
120	R:R:Y262	4.7325	4	0	7
121	R:R:H277	6.572	5	10	7
122	R:R:R281	7.67333	6	10	7
123	R:R:L291	4.23	4	10	6
124	R:R:N312	5.3525	4	30	9
125	R:R:F313	6.655	4	0	6
126	R:R:F315	5.5575	4	31	8
127	R:R:M327	5.0725	4	0	7
128	R:R:I354	4.522	5	30	6
129	R:R:F356	8.3625	4	29	7
130	R:R:Y372	3.6625	4	13	7
131	R:R:H381	5.9075	4	0	9
132	R:R:F382	4.302	5	9	7
133	R:R:F385	5.294	5	9	5
134	R:R:Y391	4.2975	4	9	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	B:B:D76	B:B:K78	26.2934	8.3	Yes	Yes	0	9	8
2	A:A:Y37	B:B:D76	26.8954	4.6	Yes	Yes	1	4	9
3	A:A:Y37	B:B:Q75	25.5171	4.51	Yes	Yes	1	4	9
4	B:B:M325	G:G:P49	11.4299	3.35	Yes	No	0	5	7
5	G:G:D48	G:G:P49	11.5536	4.83	Yes	No	0	9	7
6	G:G:D48	G:G:L50	30.9904	4.07	Yes	No	0	9	9
7	B:B:V327	G:G:L50	31.0308	4.47	No	No	0	6	9
8	B:B:L286	B:B:V327	31.1172	4.47	No	No	0	7	6
9	B:B:L286	B:B:L318	31.8635	4.15	No	Yes	0	7	6
10	B:B:L318	B:B:T329	100	2.95	Yes	No	0	6	8
11	B:B:H311	B:B:T329	98.6938	8.21	Yes	No	0	9	8
12	B:B:D333	B:B:H311	97.0712	6.3	No	Yes	23	9	9
13	B:B:D312	B:B:D333	97.1239	5.32	No	No	0	5	9
14	B:B:D312	R:R:R404	96.8092	10.72	No	No	0	5	7
15	R:R:R404	R:R:T401	95.4486	6.47	No	No	0	7	7
16	R:R:E397	R:R:T401	94.4742	7.06	No	No	0	9	7
17	R:R:E397	R:R:L176	94.3104	13.25	No	Yes	0	9	9
18	R:R:F170	R:R:L176	93.5798	10.96	Yes	Yes	12	8	9
19	R:R:F170	R:R:F188	93.1013	3.22	Yes	Yes	0	8	8
20	R:R:F188	R:R:L163	92.1678	8.53	Yes	No	0	8	8
21	R:R:L163	R:R:Y191	91.8195	4.69	No	Yes	0	8	8
22	R:R:M187	R:R:Y191	62.8205	7.18	Yes	Yes	0	8	8
23	R:R:E240	R:R:M187	50.0757	5.41	No	Yes	0	9	8
24	R:R:E240	R:R:H184	49.814	8.62	No	No	0	9	9
25	R:R:H184	R:R:R180	49.5577	6.77	No	No	0	9	9
26	A:A:Y391	R:R:R180	49.0472	7.2	Yes	No	0	4	9
27	A:A:L393	A:A:Y391	49.8415	2.34	No	Yes	0	8	4
28	A:A:L388	A:A:L393	48.4321	2.77	No	No	0	8	8
29	A:A:L388	R:R:L323	48.1485	4.15	No	No	0	8	9
30	R:R:L323	R:R:M327	47.8644	5.65	No	Yes	0	9	7
31	A:A:L394	R:R:M327	46.4354	4.24	No	Yes	0	8	7
32	A:A:L394	A:A:R385	45.8598	3.64	No	No	0	8	5
33	A:A:R385	A:A:Y360	45.2433	4.12	No	Yes	16	5	8
34	A:A:D378	A:A:Y360	14.9135	13.79	No	Yes	0	7	8
35	A:A:D378	A:A:H362	13.5357	13.87	No	No	0	7	9
36	A:A:F290	A:A:H362	12.8435	3.39	No	No	0	9	9
37	A:A:F290	A:A:I245	11.1031	2.51	No	Yes	0	9	7
38	R:R:M187	R:R:W236	12.3709	3.49	Yes	Yes	0	8	9
39	B:B:Q75	B:B:W99	20.1125	5.48	Yes	Yes	1	9	9
40	A:A:I382	A:A:Y360	26.9091	6.04	No	Yes	0	6	8
41	A:A:I382	A:A:S286	26.5857	3.1	No	No	0	6	8
42	A:A:H357	A:A:S286	26.2617	2.79	No	No	0	7	8
43	A:A:H357	A:A:W277	24.5539	29.62	No	Yes	3	7	6
44	A:A:F273	A:A:W277	22.2626	7.02	Yes	Yes	3	9	6
45	A:A:E209	B:B:W99	24.6052	6.54	Yes	Yes	1	9	9
46	A:A:E209	B:B:S97	51.1892	5.75	Yes	No	0	9	8
47	B:B:L117	B:B:W99	37.4863	3.42	Yes	Yes	1	9	9
48	B:B:L117	B:B:Y145	55.3398	3.52	Yes	Yes	1	9	8
49	B:B:K280	G:G:D48	25.1816	4.15	Yes	Yes	0	1	9
50	B:B:K280	G:G:H44	24.8016	3.93	Yes	Yes	2	1	6
51	G:G:H44	G:G:Y40	24.7054	7.62	Yes	No	2	6	6
52	B:B:F235	G:G:Y40	12.3656	5.16	Yes	No	2	6	6
53	B:B:F235	B:B:F278	16.713	10.72	Yes	Yes	2	6	7
54	B:B:F278	B:B:L285	16.7635	4.87	Yes	Yes	2	7	6
55	B:B:L285	B:B:Y264	16.3324	3.52	Yes	Yes	2	6	5
56	B:B:W297	B:B:Y264	14.4939	13.5	Yes	Yes	2	8	5
57	B:B:W297	B:B:Y289	11.1444	3.86	Yes	Yes	2	8	7
58	B:B:C271	B:B:Y289	12.351	4.03	No	Yes	0	5	7
59	B:B:C271	B:B:D290	12.2141	3.11	No	Yes	0	5	6
60	A:A:E344	A:A:L270	10.6272	2.65	No	Yes	0	5	6
61	B:B:N237	G:G:Y40	12.2601	13.96	Yes	No	2	5	6
62	B:B:G238	B:B:N237	14.6655	3.39	No	Yes	2	7	5
63	B:B:F234	B:B:G238	14.2246	4.52	Yes	No	2	5	7
64	B:B:F234	B:B:F241	10.9368	3.22	Yes	Yes	2	5	6
65	B:B:L318	B:B:S275	76.1686	4.5	Yes	No	0	6	8
66	B:B:A231	B:B:S275	76.1877	1.71	No	No	0	5	8
67	B:B:A231	B:B:S189	76.227	1.71	No	No	0	5	7
68	B:B:C148	B:B:S189	76.2797	3.44	No	No	0	6	7
69	B:B:C148	B:B:R150	78.4784	5.57	No	No	0	6	6
70	B:B:H62	B:B:R150	78.5485	7.9	No	No	0	6	6
71	B:B:H62	B:B:Y105	78.6478	3.27	No	Yes	0	6	6
72	B:B:K78	B:B:P94	27.0376	10.04	Yes	No	0	8	5
73	B:B:I93	B:B:P94	27.2541	3.39	Yes	No	0	7	5
74	B:B:I93	B:B:L79	13.7498	8.56	Yes	Yes	0	7	7
75	B:B:L79	B:B:V112	31.136	2.98	Yes	Yes	0	7	8
76	B:B:V112	B:B:Y105	78.5123	3.79	Yes	Yes	6	8	6
77	B:B:I93	B:B:Y124	13.729	10.88	Yes	Yes	0	7	6
78	B:B:V112	B:B:Y124	48.2296	3.79	Yes	Yes	6	8	6
79	B:B:L79	B:B:L95	17.6479	5.54	Yes	Yes	0	7	8
80	B:B:L95	B:B:Y124	17.5604	4.69	Yes	Yes	6	8	6
81	B:B:L95	B:B:V100	34.4754	4.47	Yes	No	0	8	9
82	B:B:C114	B:B:Y124	17.6437	5.38	No	Yes	6	8	6
83	B:B:D118	B:B:S97	51.4044	10.31	No	No	0	9	8
84	B:B:D118	B:B:G116	34.1506	3.35	No	No	0	9	9
85	B:B:G116	B:B:V100	34.2928	3.68	No	No	0	9	9
86	B:B:G162	B:B:Y145	46.9702	5.79	No	Yes	1	9	8
87	B:B:G162	B:B:S161	47.941	3.71	No	No	1	9	9
88	B:B:S161	B:B:T165	42.3771	4.8	No	No	1	9	7
89	B:B:T165	B:B:T179	41.3138	3.14	No	No	0	7	4
90	B:B:Q176	B:B:T179	40.2073	9.92	No	No	0	4	4
91	B:B:Q176	B:B:W169	37.9831	12.05	No	Yes	8	4	8
92	B:B:I157	B:B:W169	26.8855	4.7	No	Yes	0	7	8
93	B:B:F151	B:B:I157	22.427	10.05	Yes	No	0	9	7
94	B:B:A106	B:B:F151	15.7224	2.77	No	Yes	0	6	9
95	B:B:A106	B:B:Y111	14.603	2.67	No	Yes	0	6	4
96	B:B:C114	B:B:S122	17.5144	3.44	No	No	0	8	8
97	B:B:D118	B:B:I120	17.4813	7	No	No	0	9	6
98	B:B:I120	B:B:S122	17.46	3.1	No	No	0	6	8
99	B:B:C148	B:B:L190	17.1685	3.17	No	Yes	0	6	5
100	B:B:F199	B:B:L190	12.5232	6.09	Yes	Yes	0	9	5
101	R:R:Q383	R:R:Y191	32.4873	4.51	No	Yes	0	9	8
102	R:R:Q355	R:R:Q383	31.8658	6.4	No	No	0	8	9
103	R:R:F356	R:R:Q355	31.2437	14.05	Yes	No	0	7	8
104	R:R:F356	R:R:I380	24.2069	6.28	Yes	No	0	7	6
105	R:R:H381	R:R:I380	23.881	3.98	Yes	No	0	9	6
106	R:R:H156	R:R:H381	18.5816	8.36	Yes	Yes	0	7	9
107	R:R:H156	R:R:I198	16.2177	10.61	Yes	No	0	7	7
108	R:R:V387	R:R:Y191	12.4475	5.05	No	Yes	0	9	8
109	R:R:H226	R:R:I198	14.1696	6.63	Yes	No	0	6	7
110	R:R:H226	R:R:Q227	11.4075	4.95	Yes	No	0	6	7
111	R:R:I301	R:R:Q227	10.7113	4.12	No	No	0	7	7
112	A:A:E209	A:A:F222	25.0812	5.83	Yes	Yes	1	9	7
113	A:A:F222	B:B:L117	21.2849	4.87	Yes	Yes	1	7	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 5UZ7

PDB Summary
PDB	5UZ7
Class	B1
SubFamily	Peptide
Type	Calcitonin
SubType	CT
Species	Homo Sapiens
Ligand	-
Other Ligand(s)	-
Protein Partners	Gs/Beta1/Gamma2
PDB Resolution	4.1
Date	2017-05-03
D.O.I.	doi.org/10.1038/nature22327

Net Summary
I_min	2.95
Number of Linked Nodes	795
Number of Links	907
Number of Hubs	134
Number of Links mediated by Hubs	492
Number of Communities	31
Number of Nodes involved in Communities	201
Number of Links involved in Communities	264

Path Summary
Number Of Nodes in MetaPath	114
Number Of Links MetaPath	113
Number of Shortest Paths	576451
Length Of Smallest Path	3
Average Path Length	33.5432
Length of Longest Path	73
Minimum Path Strength	1.11
Average Path Strength	6.09641
Maximum Path Strength	20.37
Minimum Path Correlation	0.7
Average Path Correlation	0.972985
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	2.32558
Average % Of Corr. Nodes	46.2866
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	43.9991
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• amide binding • amyloid-beta binding • binding • peptide binding • calcitonin family receptor activity • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • calcitonin receptor activity • amylin receptor activity • calcitonin gene-related peptide receptor activity • calcitonin binding • calcitonin family binding • peptide hormone binding • hormone binding • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • cellular response to stimulus • positive regulation of cell communication • regulation of cellular process • positive regulation of signal transduction • response to stimulus • signaling • positive regulation of biological process • regulation of signal transduction • intracellular signal transduction • cell communication • positive regulation of response to stimulus
Gene Ontology	Biological Process	• positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • cellular response to stimulus • positive regulation of cell communication • regulation of cellular process • positive regulation of signal transduction • response to stimulus • signaling • positive regulation of biological process • regulation of signal transduction • intracellular signal transduction • cell communication • positive regulation of response to stimulus • regulation of intracellular signal transduction • intracellular signaling cassette • regulation of calcium-mediated signaling • positive regulation of calcium-mediated signaling • signal transduction • positive regulation of cellular process • regulation of biological process • regulation of signaling • positive regulation of intracellular signal transduction • regulation of response to stimulus • calcium-mediated signaling • regulation of cell communication • cellular process • positive regulation of signaling • catabolic process • negative regulation of biological process • RNA metabolic process • macromolecule catabolic process • regulation of primary metabolic process • nucleobase-containing compound metabolic process • post-transcriptional regulation of gene expression • regulation of RNA metabolic process • regulation of mRNA catabolic process • negative regulation of cellular process • regulation of nucleobase-containing compound metabolic process • RNA catabolic process • negative regulation of macromolecule metabolic process • regulation of biosynthetic process • mRNA catabolic process • negative regulation of metabolic process • primary metabolic process • regulation of macromolecule metabolic process • regulation of catabolic process • gene expression • mRNA metabolic process • macromolecule biosynthetic process • nucleic acid metabolic process • nucleobase-containing compound catabolic process • regulation of mRNA stability • regulation of gene expression • negative regulation of gene expression • biosynthetic process • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • regulation of RNA stability • nucleic acid catabolic process • metabolic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • regulation of mRNA metabolic process • regulation of metabolic process • positive regulation of ERK1 and ERK2 cascade • positive regulation of MAPK cascade • regulation of MAPK cascade • MAPK cascade • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of macromolecule biosynthetic process • positive regulation of metabolic process • positive regulation of gene expression • positive regulation of biosynthetic process • positive regulation of macromolecule metabolic process • amylin receptor 1 signaling pathway • amylin receptor signaling pathway • calcitonin family receptor signaling pathway • G protein-coupled receptor signaling pathway • regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • phosphatidylinositol 3-kinase/protein kinase B signal transduction • response to corticosteroid • response to lipid • response to hormone • response to steroid hormone • response to chemical • response to endogenous stimulus • response to glucocorticoid • adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • response to amyloid-beta • cell surface receptor signaling pathway • calcitonin gene-related peptide receptor signaling pathway • multicellular organismal process • ossification • amylin receptor 2 signaling pathway • developmental process • myeloid leukocyte differentiation • cellular developmental process • hemopoiesis • cell development • myeloid cell differentiation • cell differentiation • osteoclast differentiation • anatomical structure development • leukocyte differentiation • positive regulation of cAMP/PKA signal transduction • cAMP/PKA signal transduction • regulation of cAMP/PKA signal transduction • regulation of multicellular organismal process • negative regulation of multicellular organismal process • regulation of ossification • negative regulation of ossification • amylin receptor 3 signaling pathway • membrane-bounded organelle • cell projection • cellular anatomical structure • organelle • cilium • plasma membrane bounded cell projection • cell periphery • plasma membrane • membrane • protein-containing complex • amylin receptor complex • plasma membrane protein complex • amylin receptor complex 3 • membrane protein complex
Gene Ontology	Cellular Component	• membrane-bounded organelle • cell projection • cellular anatomical structure • organelle • cilium • plasma membrane bounded cell projection • cell periphery • plasma membrane • membrane • protein-containing complex • amylin receptor complex • plasma membrane protein complex • amylin receptor complex 3 • membrane protein complex • receptor complex • plasma membrane signaling receptor complex • G protein-coupled receptor complex • calcitonin family receptor complex • amylin receptor complex 2 • amylin receptor complex 1 • axon • neuron projection • acrosomal vesicle • intracellular anatomical structure • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle • secretory granule • secretory vesicle • cytoplasm • vesicle • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • extrinsic component of plasma membrane • catalytic complex • cytoplasmic side of membrane • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • extracellular membrane-bounded organelle • synapse • cell junction • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • organelle membrane • cytosol • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • molecular function regulator activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • sensory perception of smell • response to peptide hormone • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • skeletal system development • bone development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • localization • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • regulation of protein transport • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • trans-Golgi network
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	A
Protein	G Protein α Sub unit
UniProt	P63092
Sequence	>5UZ7_Chain_A T E D Q R N E E K A Q R E A N K K I E K Q L Q K D K Q V Y R A T H R L L L L G I F E T K F Q V D K V N F H M F D V G G Q R D E R R K W I Q C F N D V T A I I F V V A S N R L Q E A L N L F K S I W N N R W L R T I S V I L F L N E D Y F P E F A R Y T T P D P R V T R A K Y F I R D E F L R I S T A S G D G R H Y C Y P H F T C E N I R R V F N D C R D I I Q R M H L R Q Y E L L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	B
Protein	G Protein β Sub unit
UniProt	P62873
Sequence	>5UZ7_Chain_B Q S E L D Q L R Q E A E Q L K N Q I R D A R K A C A D A T L S Q I T N N I D P V G R I Q M R T R R T L R G H L A K I Y A M H W G T D S R L L V S A S Q D G K L I I W D S Y T T N K V H A I P L R S S W V M T C A Y A P S G N Y V A C G G L D N I C S I Y N L K T R E G N V R V S R E L A G H T G Y L S C C R F L D D N Q I V T S S G D T T C A L W D I E T G Q Q T T T F T G H T G D V M S L S L A P D T R L F V S G A C D A S A K L W D V R E G M C R Q T F T G H E S D I N A I C F F P N G N A F A T G S D D A T C R L F D L R A D Q E L M T Y S H D N I I C G I T S V S F S K S G R L L L A G Y D D F N C N V W D A L K A D R A G V L A G H D N R V S C L G V T D D G M A V A T G S W D S F L K I W N Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	G
Protein	G Protein γ Sub unit
UniProt	P59768
Sequence	>5UZ7_Chain_G S I A Q A R K L V E Q L K M E A N I D R I K V S K A A A D L M A Y C E A H A K E D P L L T P V P A S E N P F R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	R
Protein	Receptor
UniProt	P30988
Sequence	>5UZ7_Chain_R A F T P E K L K N A Y V L Y Y L A I V G H S L S I F T L V I S L G I F V F F R S L G C Q R V T L H K N M F L T Y I L N S M I I I I H L V E V R R D P V S C K I L H F F H Q Y M M A C N Y F W M L C E G I Y L H T L I V V A V F T E K Q R L R W Y Y L L G W G F P L V P T T I H A I T R A V Y F N D N C W L S V E T H L L Y I I H G P V M A A L V V N F F F L L N I V R V L V T K M R E T H M Y L K A V K A T M I L V P L L G I Q F V V F P K M L G K I Y D Y V M H S L I H F Q G F F V A T I Y C F C N N E V Q T T V K R Q W A Q F K I Q W N Q R W G Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7X5H	A	Amine	5-Hydroxytryptamine	5-HT_5A	Homo sapiens	5-CT	-	Gi1/β1/γ2	3.1	2022-09-14	doi.org/10.1038/s41421-022-00412-3
	7X5H (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_5A	Homo sapiens	5-CT	-		3.1	2022-09-14	doi.org/10.1038/s41421-022-00412-3
	7UM5	A	Amine	5-Hydroxytryptamine	5-HT_5A	Homo sapiens	5-CT	-	chim(NtGi1-Go)/β1/γ2	2.73	2022-07-20	doi.org/10.1038/s41594-022-00796-6
	7UM5 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_5A	Homo sapiens	5-CT	-		2.73	2022-07-20	doi.org/10.1038/s41594-022-00796-6
	7XTC	A	Amine	5-Hydroxytryptamine	5-HT₇	Homo sapiens	5-CT	-	Gs/β1/γ2	3.2	2022-07-27	doi.org/10.1016/j.molcel.2022.05.031
	7XTC (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT₇	Homo sapiens	5-CT	-		3.2	2022-07-27	doi.org/10.1016/j.molcel.2022.05.031
	6E67	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	-	Gs(CT)	3.7	2019-06-05	doi.org/10.1016/j.cell.2019.04.021
	6NIY	B1	Peptide	Calcitonin	CT	Homo sapiens	Adrenomedullin	-	Gs/β1/γ2	3.34	2019-01-23	doi.org/10.1021/acsptsci.8b00056
	6NIY (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	Adrenomedullin	-		3.34	2019-01-23	doi.org/10.1021/acsptsci.8b00056
	5UZ7	B1	Peptide	Calcitonin	CT	Homo sapiens	-	-	Gs/β1/γ2	4.1	2017-05-03	doi.org/10.1038/nature22327
	5UZ7 (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	-	-		4.1	2017-05-03	doi.org/10.1038/nature22327
	8F0J	B1	Peptide	Calcitonin	CT	Homo sapiens	Pramlintide Analogue San45	-	Gs/β1/γ2	2	2023-08-02	doi.org/10.1038/s41589-023-01393-4
	8F0J (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	Pramlintide Analogue San45	-		2	2023-08-02	doi.org/10.1038/s41589-023-01393-4
	7TYL	B1	Peptide	Calcitonin	CT	Homo sapiens	Amylin	-	Gs/β1/γ2	3.3	2022-03-23	doi.org/10.1126/science.abm9609
	7TYL (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	Amylin	-		3.3	2022-03-23	doi.org/10.1126/science.abm9609
	7TYO	B1	Peptide	Calcitonin	CT	Homo sapiens	Calcitonin	-	Gs/β1/γ2	2.7	2022-03-23	doi.org/10.1126/science.abm9609
	7TYO (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	Calcitonin	-		2.7	2022-03-23	doi.org/10.1126/science.abm9609
	7TYI	B1	Peptide	Calcitonin	CT	Homo sapiens	Amylin	-	Gs/β1/γ2	3.3	2022-03-30	doi.org/10.1126/science.abm9609
	7TYI (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	Amylin	-		3.3	2022-03-30	doi.org/10.1126/science.abm9609
	7TYN	B1	Peptide	Calcitonin	CT	Homo sapiens	Calcitonin-1	-	Gs/β1/γ2	2.6	2022-03-30	doi.org/10.1126/science.abm9609
	7TYN (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	Calcitonin-1	-		2.6	2022-03-30	doi.org/10.1126/science.abm9609
	9BUB	B1	Peptide	Calcitonin	CT	Homo sapiens	Cagrilintide	-	Gs/β1/γ2	2.3	2025-04-23	doi.org/10.1038/s41467-025-58680-y
	9BUB (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	Cagrilintide	-		2.3	2025-04-23	doi.org/10.1038/s41467-025-58680-y
	9BLB	B1	Peptide	Calcitonin	CT	Homo sapiens	Cagrilintide backbone (non-acylated)	-	Gs/β1/γ2	3.2	2025-04-16	To be published
	9BLB (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	Cagrilintide backbone (non-acylated)	-		3.2	2025-04-16	To be published
	9BLC	B1	Peptide	Calcitonin	CT	Homo sapiens	Cagrilintide backbone (non-acylated)	-	Gs/β1/γ2	3.3	2025-04-16	To be published
	9BLC (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	Cagrilintide backbone (non-acylated)	-		3.3	2025-04-16	To be published
	9BUE	B1	Peptide	Calcitonin	CT	Homo sapiens	Cagrilintide	-	Gs/β1/γ2	3.6	2025-04-16	To be published
	9BUE (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	Cagrilintide	-		3.6	2025-04-16	To be published
	9BUC	B1	Peptide	Calcitonin	CT	Homo sapiens	Cagrilintide	-	Gs/β1/γ2	3.4	2025-04-23	To be published
	9BUC (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	Cagrilintide	-		3.4	2025-04-23	To be published
	9BUD	B1	Peptide	Calcitonin	CT	Homo sapiens	Cagrilintide	-	Gs/β1/γ2	2.5	2025-04-23	To be published
	9BUD (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	Cagrilintide	-		2.5	2025-04-23	To be published
	9AUC	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Calcitonin gene-related peptide-1	-	Gs/β1/γ2; RAMP1	2.4	2024-04-24	doi.org/10.1021/acs.biochem.4c00114
	9AUC (No Gprot)	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Calcitonin gene-related peptide-1	-		2.4	2024-04-24	doi.org/10.1021/acs.biochem.4c00114
	7TYF	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Amylin	-	Gs/β1/γ2; RAMP1	2.2	2022-03-23	doi.org/10.1126/science.abm9609
	7TYF (No Gprot)	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Amylin	-		2.2	2022-03-23	doi.org/10.1126/science.abm9609
	7TYW	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Calcitonin-1	-	Gs/β1/γ2; RAMP1	3	2022-03-23	doi.org/10.1126/science.abm9609
	7TYW (No Gprot)	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Calcitonin-1	-		3	2022-03-23	doi.org/10.1126/science.abm9609
	9BLW	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Cagrilintide backbone (non-acylated)	-	Gs/β1/γ2; RAMP1	3.2	2025-04-16	To be published
	9BLW (No Gprot)	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Cagrilintide backbone (non-acylated)	-		3.2	2025-04-16	To be published
	9BP3	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Cagrilintide	-	Gs/β1/γ2; RAMP1	2.2	2025-04-23	To be published
	9BP3 (No Gprot)	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Cagrilintide	-		2.2	2025-04-23	To be published
	7TYH	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Calcitonin-1	-	Gs/β1/γ2; RAMP2	3.3	2022-03-23	doi.org/10.1126/science.abm9609
	7TYH (No Gprot)	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Calcitonin-1	-		3.3	2022-03-23	doi.org/10.1126/science.abm9609
	7TYY	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Calcitonin-1	-	Gs/β1/γ2; RAMP2	3	2022-03-23	doi.org/10.1126/science.abm9609
	7TYY (No Gprot)	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Calcitonin-1	-		3	2022-03-23	doi.org/10.1126/science.abm9609
	7TYX	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Amylin	-	Gs/β1/γ2; RAMP2	2.55	2022-03-30	doi.org/10.1126/science.abm9609
	7TYX (No Gprot)	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Amylin	-		2.55	2022-03-30	doi.org/10.1126/science.abm9609
	9BQ3	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Cagrilintide	-	Gs/β1/γ2; RAMP2	2.8	2025-04-23	To be published
	9BQ3 (No Gprot)	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Cagrilintide	-		2.8	2025-04-23	To be published
	8F0K	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Pramlintide Analogue San385	-	Gs/β1/γ2; RAMP3	1.9	2023-08-02	doi.org/10.1038/s41589-023-01393-4
	8F0K (No Gprot)	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Pramlintide Analogue San385	-		1.9	2023-08-02	doi.org/10.1038/s41589-023-01393-4
	8F2A	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Pramlintide Analogue San385	-	Gs/β1/γ2; RAMP3	2.2	2023-08-02	doi.org/10.1038/s41589-023-01393-4
	8F2A (No Gprot)	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Pramlintide Analogue San385	-		2.2	2023-08-02	doi.org/10.1038/s41589-023-01393-4
	8F2B	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Pramlintide Analogue San45	-	Gs/β1/γ2; RAMP3	2	2023-08-02	doi.org/10.1038/s41589-023-01393-4
	8F2B (No Gprot)	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Pramlintide Analogue San45	-		2	2023-08-02	doi.org/10.1038/s41589-023-01393-4
	7TZF	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Amylin	-	Gs/β1/γ2; RAMP3	2.4	2022-03-23	doi.org/10.1126/science.abm9609
	7TZF (No Gprot)	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Amylin	-		2.4	2022-03-23	doi.org/10.1126/science.abm9609
	9BTW	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Cagrilintide	-	Gs/β1/γ2; RAMP3	3	2025-04-16	To be published
	9BTW (No Gprot)	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Cagrilintide	-		3	2025-04-16	To be published
	6E3Y	B1	Peptide	Calcitonin	CT Like	Homo sapiens	Calcitonin gene-related peptide-1	-	Gs/β1/γ2; RAMP1	3.3	2018-09-19	doi.org/10.1038/s41586-018-0535-y
	6E3Y (No Gprot)	B1	Peptide	Calcitonin	CT Like	Homo sapiens	Calcitonin gene-related peptide-1	-		3.3	2018-09-19	doi.org/10.1038/s41586-018-0535-y
	7KNT	B1	Peptide	Calcitonin	CT Like	Homo sapiens	-	-	RAMP1	3.15	2021-02-24	doi.org/10.1126/science.abf7258
	7KNU	B1	Peptide	Calcitonin	CT Like	Homo sapiens	Calcitonin gene-related peptide-1	-	RAMP1	3.49	2021-02-24	doi.org/10.1126/science.abf7258
	6UUN	B1	Peptide	Calcitonin	CT Like (AM1)	Homo sapiens	Adrenomedullin	-	Gs/β1/γ2; RAMP2	3	2020-03-25	doi.org/10.1021/acsptsci.9b00080
	6UUN (No Gprot)	B1	Peptide	Calcitonin	CT Like (AM1)	Homo sapiens	Adrenomedullin	-		3	2020-03-25	doi.org/10.1021/acsptsci.9b00080
	6UUS	B1	Peptide	Calcitonin	CT Like (AM2)	Homo sapiens	Adrenomedullin	-	Gs/β1/γ2; RAMP3	2.4	2020-04-01	doi.org/10.1021/acsptsci.9b00080
	6UUS (No Gprot)	B1	Peptide	Calcitonin	CT Like (AM2)	Homo sapiens	Adrenomedullin	-		2.4	2020-04-01	doi.org/10.1021/acsptsci.9b00080
	6UVA	B1	Peptide	Calcitonin	CT Like (AM2)	Homo sapiens	Adrenomedullin-2	-	Gs/β1/γ2; RAMP3	2.3	2020-04-01	doi.org/10.1021/acsptsci.9b00080
	6UVA (No Gprot)	B1	Peptide	Calcitonin	CT Like (AM2)	Homo sapiens	Adrenomedullin-2	-		2.3	2020-04-01	doi.org/10.1021/acsptsci.9b00080
	6PH7	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	Nerol	Gt(CT)	2.9	2020-07-01	To be published
	6PGS	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	Geraniol	Gt(CT)	2.9	2020-07-01	To be published
	6PEL	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	Citronellol	Gt(CT)	3.19	2020-06-24	To be published
	4J4Q	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl β-D-Glucopyranoside	-	Gt(CT)	2.65	2013-10-30	doi.org/10.1002/anie.201302374
	4X1H	A	Sensory	Opsins	Rhodopsin	Bos taurus	Nonyl-β-D-Glucopyranoside	-	Gt(CT)	2.29	2015-11-04	doi.org/10.1016/j.str.2015.09.015
	4BEY	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	Gt(CT)	2.9	2013-05-08	doi.org/10.1038/embor.2013.44
	3DQB	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	Gt(CT)	3.2	2008-09-23	doi.org/10.1038/nature07330
	3PQR	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gt(CT)	2.85	2011-03-09	doi.org/10.1038/nature09789
	2X72	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gt(CT)	3	2011-03-16	doi.org/10.1038/nature09795
	5WKT	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl-β-D-Glucopyranoside	-	Gt(CT)	3.2	2017-12-13	doi.org/10.1038/nprot.2017.135
	4A4M	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gt(CT)	3.3	2012-01-25	doi.org/10.1073/pnas.1114089108
	5EN0	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gt(CT)	2.81	2016-08-10	doi.org/10.15252/embr.201642671
	6NWE	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl-β-D-Glucopyranoside	-	Gt(CT)	2.71	2020-02-12	To be published
	6TP4	A	Peptide	Orexin	OX₁	Homo sapiens	ACT-462206	-	-	3.01	2020-01-01	doi.org/10.1021/acs.jmedchem.9b01787

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