psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	E:E:E62	E:E:N60	5.26	No	No	0	3	3
2	E:E:V65	E:E:Y61	6.31	No	Yes	1	5	8
3	E:E:A104	E:E:Y61	4	No	Yes	0	9	8
4	E:E:F107	E:E:Y61	3.09	No	Yes	0	5	8
5	E:E:L109	E:E:Y61	3.52	No	Yes	1	7	8
6	E:E:N113	E:E:Y61	11.63	Yes	Yes	1	9	8
7	E:E:L115	E:E:Y61	5.86	No	Yes	1	4	8
8	E:E:A64	E:E:F103	5.55	No	No	0	3	1
9	E:E:L100	E:E:V65	2.98	Yes	No	1	8	5
10	E:E:I119	E:E:V65	3.07	No	No	1	5	5
11	E:E:C68	E:E:F67	4.19	No	No	0	9	1
12	E:E:C68	E:E:C99	7.28	No	No	0	9	9
13	E:E:W69	E:E:Y72	4.82	Yes	Yes	1	6	9
14	E:E:K73	E:E:W69	3.48	No	Yes	0	5	6
15	E:E:L96	E:E:W69	3.42	No	Yes	1	8	6
16	E:E:T123	E:E:W69	6.06	No	Yes	1	8	6
17	E:E:M76	E:E:Y72	10.78	Yes	Yes	1	9	9
18	E:E:P92	E:E:Y72	2.78	Yes	Yes	1	6	9
19	E:E:Y72	E:E:Y93	3.97	Yes	Yes	1	9	9
20	E:E:L96	E:E:Y72	14.07	No	Yes	1	8	9
21	E:E:T123	E:E:Y72	7.49	No	Yes	1	8	9
22	E:E:H127	E:E:Y72	4.36	Yes	Yes	1	8	9
23	E:E:P92	E:E:Q75	3.16	Yes	No	0	6	3
24	E:E:M76	E:E:W83	6.98	Yes	No	1	9	7
25	E:E:I89	E:E:M76	8.75	No	Yes	0	8	9
26	E:E:M76	E:E:P92	5.03	Yes	Yes	1	9	6
27	E:E:H127	E:E:M76	9.19	Yes	Yes	1	8	9
28	E:E:D77	E:E:P78	8.05	No	No	0	4	5
29	E:E:I79	E:E:K81	7.27	No	No	8	7	5
30	E:E:D82	E:E:I79	7	No	No	8	6	7
31	E:E:E80	E:E:W83	8.72	No	No	0	5	7
32	E:E:D82	E:E:K81	11.06	No	No	8	6	5
33	E:E:D82	E:E:M88	16.63	No	No	0	6	5
34	E:E:H127	E:E:W83	12.7	Yes	No	1	8	7
35	E:E:C131	E:E:C84	7.28	No	No	0	9	9
36	E:E:A87	E:E:D85	4.63	No	No	0	5	7
37	E:E:D85	E:E:M88	9.7	No	No	0	7	5
38	E:E:I89	E:E:W86	3.52	No	Yes	0	8	9
39	E:E:S90	E:E:W86	8.65	No	Yes	0	7	9
40	E:E:W86	R:R:D50	4.47	Yes	No	0	9	2
41	E:E:W86	R:R:Y53	5.79	Yes	No	0	9	1
42	E:E:P92	E:E:R91	2.88	Yes	No	0	6	6
43	E:E:H124	E:E:Y93	9.8	Yes	Yes	1	9	9
44	E:E:Y93	R:R:M49	3.59	Yes	Yes	1	9	4
45	E:E:Y93	R:R:Q52	6.76	Yes	Yes	1	9	6
46	E:E:S94	R:R:M49	6.13	No	Yes	0	8	4
47	E:E:I120	E:E:L96	2.85	No	No	0	9	8
48	E:E:E101	E:E:R97	6.98	No	Yes	1	8	7
49	E:E:F111	E:E:R97	10.69	Yes	Yes	1	8	7
50	E:E:R97	L:L:Y37	4.12	Yes	Yes	1	7	0
51	E:E:R97	R:R:M48	8.69	Yes	No	1	7	6
52	E:E:R97	R:R:M49	7.44	Yes	Yes	1	7	4
53	E:E:R97	R:R:Q52	10.51	Yes	Yes	1	7	6
54	E:E:R97	R:R:W76	5	Yes	Yes	1	7	8
55	E:E:R97	R:R:G78	3	Yes	Yes	1	7	5
56	E:E:C99	E:E:D98	3.11	No	No	0	9	1
57	E:E:D98	E:E:H102	6.3	No	No	0	1	1
58	E:E:F111	E:E:L100	4.87	Yes	Yes	1	8	8
59	E:E:A116	E:E:L100	4.73	No	Yes	1	9	8
60	E:E:I119	E:E:L100	5.71	No	Yes	1	5	8
61	E:E:I120	E:E:L100	2.85	No	Yes	0	9	8
62	E:E:E101	E:E:F111	7	No	Yes	1	8	8
63	E:E:E101	L:L:Y37	3.37	No	Yes	1	8	0
64	E:E:F107	E:E:L106	7.31	No	No	0	5	1
65	E:E:L109	E:E:N113	6.87	No	Yes	1	7	9
66	E:E:F111	E:E:P112	7.22	Yes	No	0	8	9
67	E:E:A116	E:E:F111	2.77	No	Yes	1	9	8
68	E:E:F111	L:L:Y37	3.09	Yes	Yes	1	8	0
69	E:E:E117	E:E:P112	4.72	No	No	0	8	9
70	E:E:L115	E:E:N113	5.49	No	Yes	1	4	9
71	E:E:A116	E:E:N113	4.69	No	Yes	1	9	9
72	E:E:L115	E:E:R118	6.07	No	No	0	4	4
73	E:E:E117	R:R:Y56	5.61	No	Yes	0	8	3
74	E:E:E117	R:R:T75	4.23	No	No	0	8	5
75	E:E:I120	R:R:Y56	12.09	No	Yes	0	9	3
76	E:E:F121	R:R:Y56	10.32	No	Yes	0	6	3
77	E:E:F121	R:R:M59	8.71	No	No	0	6	5
78	E:E:H124	E:E:T123	5.48	Yes	No	1	9	8
79	E:E:F128	E:E:H124	12.44	No	Yes	1	9	9
80	E:E:H124	R:R:Y53	5.44	Yes	No	1	9	1
81	E:E:H124	R:R:Y56	7.62	Yes	Yes	1	9	3
82	E:E:Q125	R:R:Q60	12.8	No	No	0	5	3
83	E:E:H127	E:E:I126	9.28	Yes	No	0	8	5
84	E:E:F128	R:R:Y53	10.32	No	No	1	9	1
85	E:E:Q135	E:E:V134	2.87	No	No	0	5	5
86	E:E:P136	E:E:Q135	3.16	No	No	0	6	5
87	E:E:Q135	E:E:S139	4.33	No	No	0	5	5
88	E:E:P136	R:R:K54	3.35	No	No	0	6	4
89	E:E:F138	E:E:T137	9.08	No	No	0	4	6
90	E:E:F138	R:R:F285	6.43	No	Yes	0	4	6
91	E:E:D140	E:E:P141	4.83	No	Yes	0	9	9
92	E:E:D140	R:R:T295	8.67	No	Yes	0	9	4
93	E:E:D140	R:R:H296	5.04	No	No	0	9	2
94	E:E:P141	E:E:P142	3.9	Yes	No	0	9	9
95	E:E:P141	R:R:Y284	22.25	Yes	No	0	9	2
96	E:E:P141	R:R:L297	4.93	Yes	Yes	0	9	4
97	E:E:D144	E:E:P142	4.83	No	No	9	7	9
98	E:E:P142	E:E:V145	3.53	No	No	9	9	7
99	E:E:D144	E:E:V145	5.84	No	No	9	7	7
100	E:E:I150	E:E:L146	2.85	No	No	0	9	8
101	E:E:M149	R:R:T280	4.52	No	No	0	9	4
102	E:E:M149	R:R:I300	2.92	No	No	0	9	8
103	E:E:I150	R:R:Y299	3.63	No	No	0	9	7
104	E:E:P153	R:R:P273	3.9	No	Yes	2	9	6
105	E:E:P153	R:R:P304	3.9	No	Yes	2	9	9
106	E:E:I154	R:R:P304	6.77	No	Yes	0	9	9
107	E:E:L156	E:E:L160	4.15	No	No	2	9	9
108	E:E:L156	R:R:F269	4.87	No	Yes	2	9	3
109	E:E:I157	E:E:P158	3.39	Yes	No	0	9	9
110	E:E:I157	E:E:I161	2.94	Yes	No	0	9	9
111	E:E:I157	R:R:F235	5.02	Yes	Yes	2	9	5
112	E:E:I157	R:R:F269	5.02	Yes	Yes	2	9	3
113	E:E:L160	R:R:L264	2.77	No	No	0	9	3
114	E:E:L160	R:R:F269	4.87	No	Yes	2	9	3
115	E:E:I161	R:R:I242	2.94	No	Yes	0	9	7
116	E:E:L163	R:R:W261	7.97	No	Yes	0	9	2
117	E:E:V164	R:R:Y262	8.83	No	Yes	0	9	7
118	E:E:V165	E:E:W166	4.9	No	No	0	9	8
119	E:E:S168	R:R:Q257	4.33	No	Yes	0	9	5
120	E:E:S168	R:R:W261	4.94	No	Yes	0	9	2
121	E:E:D170	E:E:S171	2.94	No	No	0	8	6
122	L:L:K1	L:L:R11	4.95	No	No	0	0	0
123	L:L:K1	R:R:V293	4.55	No	No	0	0	6
124	L:L:C2	L:L:T4	3.38	Yes	No	2	0	0
125	L:L:C2	L:L:C7	7.28	Yes	No	2	0	0
126	L:L:C2	R:R:Y299	8.06	Yes	No	0	0	7
127	L:L:C2	R:R:H302	2.95	Yes	Yes	2	0	6
128	L:L:N3	L:L:R11	4.82	No	No	0	0	0
129	L:L:N3	R:R:W361	18.08	No	No	0	0	4
130	L:L:N3	R:R:R362	4.82	No	Yes	0	0	4
131	L:L:T4	L:L:T6	3.14	No	Yes	2	0	0
132	L:L:C7	L:L:T4	3.38	No	No	2	0	0
133	L:L:A5	R:R:F356	2.77	No	Yes	0	0	7
134	L:L:T6	R:R:Y234	7.49	Yes	Yes	2	0	7
135	L:L:T6	R:R:H302	8.21	Yes	Yes	2	0	6
136	L:L:T6	R:R:V305	4.76	Yes	No	2	0	7
137	L:L:T6	R:R:M306	4.52	Yes	No	0	0	4
138	L:L:C7	R:R:H302	7.37	No	Yes	2	0	6
139	L:L:A8	L:L:R11	4.15	No	No	0	0	0
140	L:L:A8	R:R:H377	4.39	No	Yes	0	0	7
141	L:L:Q10	L:L:T9	4.25	Yes	No	0	0	0
142	L:L:Q10	R:R:Q227	6.4	Yes	Yes	2	0	7
143	L:L:Q10	R:R:M230	5.44	Yes	Yes	2	0	6
144	L:L:Q10	R:R:H302	7.42	Yes	Yes	2	0	6
145	L:L:L12	L:L:L16	4.15	No	Yes	3	0	0
146	L:L:L12	R:R:L148	2.77	No	Yes	3	0	5
147	L:L:L12	R:R:H377	6.43	No	Yes	3	0	7
148	L:L:A13	R:R:H201	2.93	No	No	0	0	6
149	L:L:N14	L:L:R18	6.03	No	No	0	0	0
150	L:L:N14	R:R:V293	7.39	No	No	0	0	6
151	L:L:F15	L:L:R18	5.34	Yes	No	0	0	0
152	L:L:F15	L:L:S19	13.21	Yes	No	0	0	0
153	L:L:F15	R:R:K141	9.93	Yes	No	0	0	3
154	L:L:F15	R:R:L142	6.09	Yes	No	0	0	2
155	L:L:F15	R:R:A145	2.77	Yes	No	0	0	4
156	L:L:L16	L:L:L23	5.54	Yes	No	3	0	0
157	L:L:L16	R:R:Y149	4.69	Yes	Yes	3	0	5
158	L:L:L16	R:R:V206	2.98	Yes	Yes	0	0	3
159	L:L:V17	R:R:V206	4.81	No	Yes	0	0	3
160	L:L:V17	R:R:V212	4.81	No	No	5	0	3
161	L:L:V17	R:R:L291	4.47	No	No	5	0	6
162	L:L:S19	L:L:S20	3.26	No	Yes	0	0	0
163	L:L:L23	L:L:S20	6.01	No	Yes	3	0	0
164	L:L:S20	R:R:L142	6.01	Yes	No	3	0	2
165	L:L:S20	R:R:Y146	6.36	Yes	No	3	0	2
166	L:L:N21	L:L:P25	11.4	No	No	0	0	0
167	L:L:N22	R:R:G209	5.09	No	No	0	0	3
168	L:L:L23	R:R:Y149	7.03	No	Yes	3	0	5
169	L:L:G24	L:L:P25	4.06	No	No	0	0	0
170	L:L:L27	L:L:P28	6.57	No	No	0	0	0
171	L:L:P29	R:R:D101	3.22	No	No	0	0	4
172	L:L:T30	R:R:F99	11.67	Yes	Yes	1	0	5
173	L:L:T30	R:R:D101	4.34	Yes	No	0	0	4
174	L:L:T30	R:R:F102	6.49	Yes	Yes	1	0	4
175	L:L:T30	R:R:N135	2.92	Yes	No	1	0	3
176	L:L:N31	L:L:T36	8.77	No	No	0	0	0
177	L:L:V32	R:R:N135	11.82	No	No	0	0	3
178	L:L:N35	L:L:S34	2.98	No	Yes	6	0	0
179	L:L:S34	R:R:H121	8.37	Yes	Yes	6	0	4
180	L:L:S34	R:R:E123	5.75	Yes	No	6	0	4
181	L:L:S34	R:R:N124	5.96	Yes	No	6	0	5
182	L:L:N35	R:R:N124	4.09	No	No	6	0	5
183	L:L:T36	R:R:W79	3.64	No	Yes	0	0	6
184	L:L:?38	L:L:Y37	2.9	Yes	Yes	1	0	0
185	L:L:Y37	R:R:D77	4.6	Yes	Yes	1	0	9
186	L:L:Y37	R:R:G78	10.14	Yes	Yes	1	0	5
187	L:L:Y37	R:R:W79	12.54	Yes	Yes	1	0	6
188	L:L:?38	R:R:D77	3.36	Yes	Yes	1	0	9
189	L:L:?38	R:R:W128	11.28	Yes	Yes	0	0	5
190	L:L:?38	R:R:S129	3.72	Yes	Yes	1	0	7
191	R:R:L40	R:R:R213	3.64	No	No	0	5	2
192	R:R:V42	R:R:Y41	3.79	No	No	0	1	3
193	R:R:K46	R:R:K47	4.31	No	Yes	1	4	4
194	R:R:D97	R:R:K47	5.53	No	Yes	0	2	4
195	R:R:M48	R:R:M49	4.33	No	Yes	1	6	4
196	R:R:M48	R:R:Y98	4.79	No	Yes	1	6	4
197	R:R:M49	R:R:Q52	6.8	Yes	Yes	1	4	6
198	R:R:D50	R:R:K54	13.83	No	No	0	2	4
199	R:R:Q52	R:R:Y56	3.38	Yes	Yes	1	6	3
200	R:R:Q52	R:R:W76	13.14	Yes	Yes	1	6	8
201	R:R:C55	R:R:W76	10.45	No	Yes	1	9	8
202	R:R:C55	R:R:C81	7.28	No	No	1	9	9
203	R:R:W76	R:R:Y56	10.61	Yes	Yes	1	8	3
204	R:R:D57	R:R:Q61	13.05	No	No	0	4	3
205	R:R:L62	R:R:R58	12.15	Yes	No	0	3	3
206	R:R:M59	R:R:R74	11.17	No	No	0	5	4
207	R:R:E68	R:R:Y65	4.49	No	No	0	1	3
208	R:R:Y65	R:R:Y71	42.69	No	No	11	3	3
209	R:R:D84	R:R:Y65	11.49	No	No	11	4	3
210	R:R:G69	R:R:P70	4.06	No	No	0	1	1
211	R:R:N73	R:R:Y71	6.98	No	No	0	4	3
212	R:R:D84	R:R:Y71	12.64	No	No	11	4	3
213	R:R:C72	R:R:T85	5.07	No	Yes	1	9	7
214	R:R:C112	R:R:C72	7.28	No	No	1	9	9
215	R:R:C72	R:R:W118	13.06	No	Yes	1	9	9
216	R:R:T75	R:R:W118	3.64	No	Yes	0	5	9
217	R:R:G78	R:R:W76	4.22	Yes	Yes	1	5	8
218	R:R:C81	R:R:W76	3.92	No	Yes	1	9	8
219	R:R:D77	R:R:G78	3.35	Yes	Yes	1	9	5
220	R:R:D77	R:R:W82	4.47	Yes	Yes	1	9	9
221	R:R:D77	R:R:S129	8.83	Yes	Yes	1	9	7
222	R:R:D77	R:R:Y131	10.34	Yes	Yes	1	9	5
223	R:R:W79	R:R:Y98	5.79	Yes	Yes	1	6	4
224	R:R:F99	R:R:W79	10.02	Yes	Yes	1	5	6
225	R:R:F102	R:R:W79	5.01	Yes	Yes	1	4	6
226	R:R:W79	R:R:Y131	13.5	Yes	Yes	1	6	5
227	R:R:L80	R:R:W82	4.56	Yes	Yes	1	5	9
228	R:R:L80	R:R:Q93	18.63	Yes	No	1	5	6
229	R:R:L80	R:R:P96	11.49	Yes	Yes	1	5	9
230	R:R:L80	R:R:V108	2.98	Yes	Yes	1	5	7
231	R:R:L80	R:R:Y131	4.69	Yes	Yes	1	5	5
232	R:R:S91	R:R:W82	9.88	No	Yes	1	5	9
233	R:R:Q93	R:R:W82	12.05	No	Yes	1	6	9
234	R:R:V108	R:R:W82	4.9	Yes	Yes	1	7	9
235	R:R:K110	R:R:W82	16.24	Yes	Yes	1	8	9
236	R:R:S129	R:R:W82	3.71	Yes	Yes	1	7	9
237	R:R:P86	R:R:T85	3.5	No	Yes	0	2	7
238	R:R:C112	R:R:T85	3.38	No	Yes	1	9	7
239	R:R:T85	R:R:W118	7.28	Yes	Yes	1	7	9
240	R:R:P86	R:R:V89	8.84	No	No	0	2	5
241	R:R:K110	R:R:S91	4.59	Yes	No	1	8	5
242	R:R:C95	R:R:V108	3.42	No	Yes	0	9	7
243	R:R:C134	R:R:C95	7.28	No	No	0	9	9
244	R:R:P96	R:R:Y98	13.91	Yes	Yes	1	9	4
245	R:R:F102	R:R:P96	5.78	Yes	Yes	1	4	9
246	R:R:P96	R:R:Y131	2.78	Yes	Yes	1	9	5
247	R:R:F99	R:R:Y98	5.16	Yes	Yes	1	5	4
248	R:R:F102	R:R:F99	10.72	Yes	Yes	1	4	5
249	R:R:C134	R:R:F102	8.38	No	Yes	0	9	4
250	R:R:F102	R:R:N135	6.04	Yes	No	1	4	3
251	R:R:D103	R:R:P104	6.44	Yes	No	0	3	3
252	R:R:D103	R:R:S105	8.83	Yes	No	0	3	1
253	R:R:D103	R:R:E106	5.2	Yes	Yes	0	3	4
254	R:R:D103	R:R:K141	2.77	Yes	No	0	3	3
255	R:R:E106	R:R:M133	13.53	Yes	No	0	4	5
256	R:R:E106	R:R:F137	5.83	Yes	No	12	4	1
257	R:R:E106	R:R:K366	5.4	Yes	No	12	4	3
258	R:R:K107	R:R:T109	4.5	No	No	0	3	5
259	R:R:K107	R:R:M133	5.76	No	No	0	3	5
260	R:R:V108	R:R:Y131	12.62	Yes	Yes	1	7	5
261	R:R:N130	R:R:T109	5.85	No	No	0	8	5
262	R:R:K110	R:R:W118	17.4	Yes	Yes	1	8	9
263	R:R:K110	R:R:T127	3	Yes	No	0	8	4
264	R:R:K110	R:R:S129	12.24	Yes	Yes	1	8	7
265	R:R:F119	R:R:Y111	6.19	No	No	0	4	4
266	R:R:C112	R:R:W118	7.84	No	Yes	1	9	9
267	R:R:D113	R:R:V117	7.3	No	No	0	5	5
268	R:R:F119	R:R:W128	4.01	No	Yes	0	4	5
269	R:R:K120	R:R:T127	7.51	No	No	0	1	4
270	R:R:H121	R:R:P122	10.68	Yes	No	0	4	5
271	R:R:E123	R:R:H121	4.92	No	Yes	6	4	4
272	R:R:H121	R:R:W128	19.04	Yes	Yes	0	4	5
273	R:R:N124	R:R:R126	4.82	No	No	0	5	4
274	R:R:N125	R:R:R126	4.82	No	No	0	7	4
275	R:R:N130	R:R:W128	11.3	No	Yes	0	8	5
276	R:R:S129	R:R:Y131	5.09	Yes	Yes	1	7	5
277	R:R:N130	R:R:T132	7.31	No	No	0	8	6
278	R:R:F137	R:R:K366	8.69	No	No	12	1	3
279	R:R:P139	R:R:T138	3.5	No	No	0	3	2
280	R:R:E140	R:R:K143	9.45	No	No	0	2	1
281	R:R:E140	R:R:N144	3.94	No	No	0	2	4
282	R:R:L142	R:R:Y146	10.55	No	No	3	2	2
283	R:R:K370	R:R:N144	5.6	No	No	3	4	4
284	R:R:N144	R:R:Y374	4.65	No	Yes	3	4	6
285	R:R:V147	R:R:Y374	3.79	No	Yes	0	4	6
286	R:R:D373	R:R:L148	4.07	No	Yes	0	5	5
287	R:R:H377	R:R:L148	10.29	Yes	Yes	3	7	5
288	R:R:Y149	R:R:Y150	11.91	Yes	No	0	5	4
289	R:R:L202	R:R:Y149	4.69	No	Yes	0	7	5
290	R:R:I153	R:R:Y150	4.84	No	No	0	7	4
291	R:R:L151	R:R:S378	6.01	No	No	0	5	5
292	R:R:F382	R:R:L151	3.65	No	No	0	7	5
293	R:R:A152	R:R:H381	7.32	No	Yes	0	7	9
294	R:R:I153	R:R:L202	2.85	No	No	0	7	7
295	R:R:F382	R:R:G155	9.03	No	No	0	7	8
296	R:R:H156	R:R:S195	9.76	Yes	No	0	7	7
297	R:R:H156	R:R:I198	5.3	Yes	Yes	0	7	7
298	R:R:H156	R:R:H381	11.94	Yes	Yes	0	7	9
299	R:R:F385	R:R:L158	3.65	Yes	No	0	5	4
300	R:R:G384	R:R:S159	3.71	No	No	0	9	9
301	R:R:I160	R:R:S195	3.1	No	No	0	5	7
302	R:R:F161	R:R:I165	3.77	No	No	0	4	5
303	R:R:F385	R:R:T162	7.78	Yes	No	0	5	6
304	R:R:A388	R:R:T162	3.36	No	No	0	8	6
305	R:R:F393	R:R:T162	3.89	Yes	No	0	8	6
306	R:R:F188	R:R:L163	6.09	Yes	No	0	8	8
307	R:R:I192	R:R:L163	2.85	No	No	0	7	8
308	R:R:A388	R:R:L163	3.15	No	No	0	8	8
309	R:R:F393	R:R:I165	3.77	Yes	No	0	8	5
310	R:R:A388	R:R:S166	3.42	No	No	0	8	9
311	R:R:C392	R:R:S166	6.89	No	No	13	9	9
312	R:R:F393	R:R:S166	6.61	Yes	No	13	8	9
313	R:R:K185	R:R:L167	2.82	No	No	0	6	6
314	R:R:F188	R:R:L167	3.65	Yes	No	0	8	6
315	R:R:F173	R:R:I169	3.77	Yes	No	0	7	8
316	R:R:F170	R:R:L176	3.65	Yes	No	0	8	9
317	R:R:F170	R:R:V181	11.8	Yes	No	0	8	9
318	R:R:F170	R:R:H184	5.66	Yes	Yes	0	8	9
319	R:R:F170	R:R:K185	3.72	Yes	No	0	8	6
320	R:R:F170	R:R:F188	6.43	Yes	Yes	0	8	8
321	R:R:F172	R:R:F173	8.57	No	Yes	0	2	7
322	R:R:F173	R:R:Q405	10.54	Yes	No	0	7	4
323	R:R:S175	R:R:T401	3.2	No	No	0	8	7
324	R:R:L176	R:R:V398	4.47	No	No	0	9	9
325	R:R:L176	R:R:T401	4.42	No	No	0	9	7
326	R:R:C178	R:R:R180	5.57	No	No	0	8	9
327	R:R:C178	R:R:V181	3.42	No	No	0	8	9
328	R:R:Q179	R:R:Y243	10.15	Yes	Yes	0	7	8
329	R:R:K256	R:R:Q179	12.2	No	Yes	0	5	7
330	R:R:Q179	R:R:Q257	6.4	Yes	Yes	0	7	5
331	R:R:L259	R:R:Q179	9.32	Yes	Yes	0	5	7
332	R:R:H184	R:R:R180	6.77	Yes	No	0	9	9
333	R:R:E397	R:R:R180	3.49	No	No	0	9	9
334	R:R:L259	R:R:T182	2.95	Yes	No	0	5	5
335	R:R:L183	R:R:W236	3.42	Yes	Yes	2	8	9
336	R:R:L183	R:R:Y243	4.69	Yes	Yes	2	8	8
337	R:R:L183	R:R:L259	2.77	Yes	Yes	2	8	5
338	R:R:L183	R:R:Y262	4.69	Yes	Yes	2	8	7
339	R:R:E240	R:R:H184	9.85	No	Yes	0	9	9
340	R:R:H184	R:R:Y391	3.27	Yes	No	0	9	8
341	R:R:N186	R:R:W236	11.3	No	Yes	2	9	9
342	R:R:N186	R:R:Y263	5.81	No	No	2	9	5
343	R:R:N186	R:R:W267	7.91	No	Yes	2	9	9
344	R:R:M187	R:R:Y191	8.38	No	Yes	2	8	8
345	R:R:M187	R:R:M237	4.33	No	Yes	2	8	9
346	R:R:E240	R:R:M187	12.18	No	No	0	9	8
347	R:R:F188	R:R:V387	3.93	Yes	No	0	8	9
348	R:R:L189	R:R:L193	2.77	No	No	0	3	6
349	R:R:L189	R:R:W267	3.42	No	Yes	0	3	9
350	R:R:N233	R:R:T190	8.77	Yes	No	2	9	9
351	R:R:T190	R:R:W236	6.06	No	Yes	2	9	9
352	R:R:T190	R:R:W267	3.64	No	Yes	2	9	9
353	R:R:N233	R:R:Y191	12.79	Yes	Yes	2	9	8
354	R:R:M237	R:R:Y191	5.99	Yes	Yes	2	9	8
355	R:R:Q383	R:R:Y191	12.4	Yes	Yes	2	9	8
356	R:R:G384	R:R:Y191	5.79	No	Yes	0	9	8
357	R:R:V387	R:R:Y191	6.31	No	Yes	0	9	8
358	R:R:L193	R:R:M229	4.24	No	No	0	6	4
359	R:R:I198	R:R:N194	5.66	Yes	No	0	7	8
360	R:R:N194	R:R:N233	9.54	No	Yes	0	8	9
361	R:R:H226	R:R:I197	3.98	No	No	0	6	5
362	R:R:I197	R:R:M229	2.92	No	No	0	5	4
363	R:R:I198	R:R:L202	2.85	Yes	No	0	7	7
364	R:R:H226	R:R:I198	3.98	No	Yes	0	6	7
365	R:R:E204	R:R:I200	5.47	No	No	0	4	6
366	R:R:H201	R:R:V205	9.69	No	No	0	6	7
367	R:R:H201	R:R:V206	2.77	No	Yes	0	6	3
368	R:R:P207	R:R:V206	3.53	No	Yes	0	3	3
369	R:R:L211	R:R:N208	5.49	Yes	No	0	1	3
370	R:R:E210	R:R:R214	15.12	No	No	0	3	4
371	R:R:L211	R:R:R214	3.64	Yes	No	0	1	4
372	R:R:L211	R:R:P216	6.57	Yes	No	5	1	4
373	R:R:C219	R:R:L211	3.17	No	Yes	5	9	1
374	R:R:C289	R:R:V212	6.83	No	No	5	9	3
375	R:R:L291	R:R:V212	2.98	No	No	5	6	3
376	R:R:D215	R:R:K220	8.3	No	No	0	6	7
377	R:R:D215	R:R:N288	17.5	No	No	0	6	4
378	R:R:P216	R:R:S218	3.56	No	No	0	4	3
379	R:R:C219	R:R:P216	7.53	No	No	5	9	4
380	R:R:C219	R:R:C289	7.28	No	No	5	9	9
381	R:R:K220	R:R:N286	5.6	No	No	4	7	7
382	R:R:K220	R:R:W290	24.37	No	Yes	4	7	9
383	R:R:H223	R:R:Q227	12.36	No	Yes	0	5	7
384	R:R:H223	R:R:W290	10.58	No	Yes	0	5	9
385	R:R:F224	R:R:F225	4.29	Yes	No	0	5	5
386	R:R:F224	R:R:T274	7.78	Yes	No	0	5	6
387	R:R:A278	R:R:F224	2.77	No	Yes	0	6	5
388	R:R:H226	R:R:Q227	4.95	No	Yes	0	6	7
389	R:R:M230	R:R:Q227	4.08	Yes	Yes	2	6	7
390	R:R:I301	R:R:Q227	9.61	No	Yes	0	7	7
391	R:R:C232	R:R:Y228	9.41	No	Yes	2	8	8
392	R:R:P270	R:R:Y228	2.78	Yes	Yes	2	9	8
393	R:R:L271	R:R:Y228	4.69	No	Yes	0	4	8
394	R:R:T274	R:R:Y228	3.75	No	Yes	0	6	8
395	R:R:M230	R:R:Y234	4.79	Yes	Yes	2	6	7
396	R:R:H302	R:R:M230	5.25	Yes	Yes	2	6	6
397	R:R:A231	R:R:P270	3.74	No	Yes	0	5	9
398	R:R:C232	R:R:W267	5.22	No	Yes	2	8	9
399	R:R:C232	R:R:P270	7.53	No	Yes	2	8	9
400	R:R:M237	R:R:N233	4.21	Yes	Yes	2	9	9
401	R:R:M237	R:R:Y234	4.79	Yes	Yes	2	9	7
402	R:R:V305	R:R:Y234	8.83	No	Yes	2	7	7
403	R:R:F356	R:R:Y234	12.38	Yes	Yes	2	7	7
404	R:R:F235	R:R:F269	8.57	Yes	Yes	2	5	3
405	R:R:F235	R:R:P270	4.33	Yes	Yes	2	5	9
406	R:R:A308	R:R:F235	4.16	No	Yes	0	7	5
407	R:R:C239	R:R:W236	6.53	No	Yes	0	7	9
408	R:R:W236	R:R:Y263	3.86	Yes	No	2	9	5
409	R:R:G266	R:R:W236	8.44	No	Yes	0	9	9
410	R:R:W236	R:R:W267	14.99	Yes	Yes	2	9	9
411	R:R:L309	R:R:M237	2.83	No	Yes	0	7	9
412	R:R:M237	R:R:Q383	5.44	Yes	Yes	2	9	9
413	R:R:I242	R:R:L238	7.14	Yes	No	0	7	8
414	R:R:A308	R:R:L238	3.15	No	No	0	7	8
415	R:R:L238	R:R:V311	2.98	No	No	0	8	6
416	R:R:C239	R:R:L265	4.76	No	No	0	7	7
417	R:R:E240	R:R:L351	6.63	No	No	0	9	9
418	R:R:I242	R:R:Y262	4.84	Yes	Yes	0	7	7
419	R:R:F315	R:R:I242	5.02	No	Yes	0	8	7
420	R:R:L247	R:R:Y243	15.24	No	Yes	0	8	8
421	R:R:Y243	R:R:Y262	5.96	Yes	Yes	2	8	7
422	R:R:I248	R:R:L244	4.28	No	Yes	0	7	9
423	R:R:I319	R:R:L244	4.28	No	Yes	0	9	9
424	R:R:L244	R:R:L348	2.77	Yes	No	0	9	9
425	R:R:H245	R:R:V249	12.45	Yes	No	14	8	6
426	R:R:H245	R:R:V250	2.77	Yes	Yes	0	8	5
427	R:R:F315	R:R:H245	20.36	No	Yes	0	8	8
428	R:R:H245	R:R:N318	6.38	Yes	No	14	8	8
429	R:R:T246	R:R:V250	4.76	No	Yes	0	7	5
430	R:R:I248	R:R:V249	3.07	No	No	0	7	6
431	R:R:I248	R:R:V322	3.07	No	No	0	7	8
432	R:R:N318	R:R:V249	2.96	No	No	14	8	6
433	R:R:Q257	R:R:T254	4.25	Yes	No	0	5	6
434	R:R:Q257	R:R:Y262	5.64	Yes	Yes	0	5	7
435	R:R:R258	R:R:R260	12.79	No	No	10	5	3
436	R:R:R258	R:R:W261	4	No	Yes	10	5	2
437	R:R:L259	R:R:Y262	3.52	Yes	Yes	2	5	7
438	R:R:L259	R:R:Y263	8.21	Yes	No	2	5	5
439	R:R:R260	R:R:W261	7	No	Yes	10	3	2
440	R:R:F269	R:R:P270	4.33	Yes	Yes	2	3	9
441	R:R:F269	R:R:V272	3.93	Yes	No	2	3	4
442	R:R:F269	R:R:P273	5.78	Yes	Yes	2	3	6
443	R:R:P273	R:R:V272	7.07	Yes	No	2	6	4
444	R:R:P273	R:R:P304	3.9	Yes	Yes	2	6	9
445	R:R:I276	R:R:I300	2.94	No	No	0	5	8
446	R:R:H277	R:R:R281	9.03	No	Yes	0	7	7
447	R:R:H277	R:R:I301	11.93	No	No	0	7	7
448	R:R:L297	R:R:T280	7.37	Yes	No	0	4	4
449	R:R:F285	R:R:R281	5.34	Yes	Yes	4	6	7
450	R:R:R281	R:R:W290	13	Yes	Yes	4	7	9
451	R:R:R281	R:R:T295	5.17	Yes	Yes	4	7	4
452	R:R:V283	R:R:Y284	5.05	No	No	0	3	2
453	R:R:D287	R:R:F285	4.78	No	Yes	4	3	6
454	R:R:F285	R:R:S292	5.28	Yes	No	4	6	4
455	R:R:F285	R:R:T295	12.97	Yes	Yes	4	6	4
456	R:R:N286	R:R:W290	5.65	No	Yes	4	7	9
457	R:R:D287	R:R:S292	7.36	No	No	4	3	4
458	R:R:C289	R:R:L291	3.17	No	No	5	9	6
459	R:R:E294	R:R:S292	2.87	No	No	0	3	4
460	R:R:L298	R:R:V293	2.98	No	No	0	6	6
461	R:R:L297	R:R:T295	5.9	Yes	Yes	0	4	4
462	R:R:H296	R:R:Y299	3.27	No	No	0	2	7
463	R:R:I300	R:R:L297	2.85	No	Yes	0	8	4
464	R:R:G303	R:R:P304	4.06	No	Yes	0	4	9
465	R:R:F356	R:R:L309	3.65	Yes	No	0	7	7
466	R:R:F315	R:R:V311	5.24	No	No	0	8	6
467	R:R:L352	R:R:N312	9.61	Yes	No	0	9	9
468	R:R:F313	R:R:L317	6.09	Yes	No	0	6	5
469	R:R:F313	R:R:I354	3.77	Yes	Yes	0	6	6
470	R:R:F313	R:R:V357	5.24	Yes	No	0	6	7
471	R:R:L316	R:R:V320	2.98	Yes	No	0	9	7
472	R:R:L316	R:R:L348	4.15	Yes	No	0	9	9
473	R:R:L316	R:R:L352	2.77	Yes	Yes	15	9	9
474	R:R:I354	R:R:L316	5.71	Yes	Yes	15	6	9
475	R:R:T345	R:R:V320	3.17	No	No	0	9	7
476	R:R:K326	R:R:V322	4.55	No	No	0	9	8
477	R:R:E329	R:R:T325	2.82	No	No	0	6	7
478	R:R:E332	R:R:M327	5.41	No	No	0	5	7
479	R:R:M327	R:R:M337	4.33	No	No	0	7	7
480	R:R:K340	R:R:M327	5.76	No	No	0	8	7
481	R:R:M337	R:R:R328	4.96	No	No	0	7	6
482	R:R:E332	R:R:T330	4.23	No	No	0	5	5
483	R:R:E332	R:R:H336	11.08	No	No	0	5	6
484	R:R:H336	R:R:K340	14.41	No	No	0	6	8
485	R:R:I347	R:R:I390	4.42	No	No	0	8	8
486	R:R:P350	R:R:V349	3.53	No	No	0	9	8
487	R:R:I354	R:R:V349	7.68	Yes	No	0	6	8
488	R:R:F386	R:R:P350	2.89	No	No	0	5	9
489	R:R:I390	R:R:P350	3.39	No	No	0	8	9
490	R:R:L351	R:R:L352	4.15	No	Yes	0	9	9
491	R:R:L351	R:R:Y391	18.76	No	No	0	9	8
492	R:R:I354	R:R:L352	4.28	Yes	Yes	15	6	9
493	R:R:G353	R:R:Q355	3.29	No	Yes	2	9	8
494	R:R:F356	R:R:G353	3.01	Yes	No	2	7	9
495	R:R:F356	R:R:Q355	12.88	Yes	Yes	2	7	8
496	R:R:L379	R:R:Q355	7.99	No	Yes	0	5	8
497	R:R:Q355	R:R:Q383	12.8	Yes	Yes	2	8	9
498	R:R:F356	R:R:I380	5.02	Yes	No	0	7	6
499	R:R:F356	R:R:Q383	4.68	Yes	Yes	2	7	9
500	R:R:F359	R:R:V358	7.87	No	No	0	6	5
501	R:R:F359	R:R:M376	4.98	No	No	0	6	7
502	R:R:P363	R:R:R362	2.88	Yes	Yes	7	7	4
503	R:R:G369	R:R:R362	4.5	No	Yes	7	4	4
504	R:R:R362	R:R:Y372	7.2	Yes	No	7	4	7
505	R:R:D373	R:R:R362	13.1	No	Yes	0	5	4
506	R:R:L368	R:R:P363	3.28	No	Yes	0	3	7
507	R:R:G369	R:R:P363	6.09	No	Yes	7	4	7
508	R:R:P363	R:R:Y372	11.13	Yes	No	7	7	7
509	R:R:L368	R:R:N365	8.24	No	No	0	3	4
510	R:R:K370	R:R:Y374	4.78	No	Yes	3	4	6
511	R:R:M376	R:R:Y372	11.97	No	No	0	7	7
512	R:R:I380	R:R:M376	2.92	No	No	0	6	7
513	R:R:H377	R:R:H381	10.75	Yes	Yes	0	7	9
514	R:R:H381	R:R:I380	5.3	Yes	No	0	9	6
515	R:R:F382	R:R:F386	4.29	No	No	0	7	5
516	R:R:F385	R:R:F386	4.29	Yes	No	0	5	5
517	R:R:F385	R:R:T389	7.78	Yes	No	0	5	5
518	R:R:I390	R:R:Y391	8.46	No	No	0	8	8
519	R:R:C392	R:R:F393	6.98	No	Yes	13	9	8
520	R:R:E397	R:R:N395	13.15	No	No	0	9	9
521	R:R:N395	R:R:V398	7.39	No	No	0	9	9
522	R:R:N396	R:R:T400	2.92	No	No	0	6	4
523	R:R:R404	R:R:T400	3.88	No	No	0	7	4
524	R:R:Q405	R:R:T401	2.83	No	No	0	4	7
525	L:L:L27	L:L:N21	2.75	No	No	0	0	0
526	E:E:H71	E:E:T95	2.74	No	No	0	1	2
527	R:R:E329	R:R:K326	2.7	No	No	0	6	9
528	E:E:A64	E:E:Y61	2.67	No	Yes	0	3	8
529	R:R:A51	R:R:Y98	2.67	No	Yes	0	8	4
530	R:R:L62	R:R:Q61	2.66	Yes	No	0	3	3
531	E:E:E143	E:E:L146	2.65	No	No	0	7	8
532	R:R:H156	R:R:I199	2.65	Yes	No	0	7	7
533	E:E:S94	R:R:R45	2.64	No	No	0	8	7
534	R:R:N396	R:R:Q399	2.64	No	No	0	6	7
535	R:R:F173	R:R:V402	2.62	Yes	No	0	7	5
536	R:R:F314	R:R:V310	2.62	No	No	0	5	4
537	E:E:R91	E:E:T95	2.59	No	No	0	6	2
538	R:R:F224	R:R:T275	2.59	Yes	No	0	5	3
539	E:E:L163	E:E:R167	2.43	No	No	0	9	8
540	R:R:K47	R:R:Y98	2.39	Yes	Yes	1	4	4
541	E:E:F121	R:R:Q60	2.34	No	No	0	6	3
542	R:R:L148	R:R:Y374	2.34	Yes	Yes	3	5	6
543	E:E:E122	E:E:W69	2.18	No	Yes	0	4	6
544	R:R:F313	R:R:F314	2.14	Yes	No	0	6	5
545	R:R:R45	R:R:Y41	2.06	No	No	0	7	3
546	R:R:G268	R:R:P270	2.03	No	Yes	0	6	9
547	L:L:P28	L:L:P29	1.95	No	No	0	0	0
548	E:E:A152	E:E:P153	1.87	No	No	0	7	9
549	L:L:G33	L:L:T36	1.82	No	No	0	0	0
550	R:R:G44	R:R:K47	1.74	No	Yes	0	4	4
551	E:E:G110	E:E:L109	1.71	No	No	0	5	7
552	R:R:G241	R:R:L244	1.71	No	Yes	0	8	9
553	R:R:G241	R:R:L352	1.71	No	Yes	0	8	9
554	R:R:A333	R:R:S335	1.71	No	No	0	5	6
555	R:R:G209	R:R:N208	1.7	No	No	0	3	3
556	R:R:A251	R:R:V250	1.7	No	Yes	0	6	5
557	R:R:A341	R:R:V324	1.7	No	No	0	9	5
558	E:E:I79	E:E:P78	1.69	No	No	0	7	5
559	R:R:C394	R:R:T389	1.69	No	No	0	5	5
560	R:R:M306	R:R:P360	1.68	No	No	0	4	5
561	E:E:C155	E:E:I151	1.64	No	No	0	7	6
562	R:R:L62	R:R:P63	1.64	Yes	No	0	3	1
563	R:R:G67	R:R:Q66	1.64	No	No	0	2	1
564	R:R:E68	R:R:G67	1.64	No	No	0	1	2
565	E:E:N113	E:E:P114	1.63	Yes	No	0	9	5
566	E:E:I154	R:R:A307	1.62	No	No	0	9	3
567	E:E:I157	R:R:A307	1.62	Yes	No	0	9	3
568	R:R:D101	R:R:P100	1.61	No	No	0	4	4
569	E:E:V165	R:R:V250	1.6	No	Yes	0	9	5
570	R:R:T325	R:R:V324	1.59	No	No	0	7	5
571	R:R:A344	R:R:L323	1.58	No	No	0	9	9
572	R:R:I199	R:R:S157	1.55	No	No	0	7	7
573	R:R:I153	R:R:V203	1.54	No	No	0	7	3
574	R:R:I165	R:R:V164	1.54	No	No	0	5	4
575	R:R:I199	R:R:V203	1.54	No	No	0	7	3
576	R:R:I221	R:R:V217	1.54	No	No	0	4	3
577	R:R:I371	R:R:V375	1.54	No	No	0	5	4
578	R:R:K46	R:R:V43	1.52	No	No	1	4	2
579	R:R:K47	R:R:V43	1.52	Yes	No	1	4	2
580	R:R:K185	R:R:V171	1.52	No	No	0	6	4
581	R:R:I279	R:R:T275	1.52	No	No	0	3	3
582	R:R:M346	R:R:V342	1.52	No	No	0	8	8
583	R:R:M346	R:R:T345	1.51	No	No	0	8	9
584	R:R:G209	R:R:R213	1.5	No	No	0	3	2
585	R:R:L222	R:R:V205	1.49	No	No	0	6	7
586	R:R:L379	R:R:V375	1.49	No	No	0	5	4
587	R:R:I160	R:R:M196	1.46	No	No	0	5	4
588	R:R:I197	R:R:M196	1.46	No	No	0	5	4
589	R:R:I200	R:R:M196	1.46	No	No	0	6	4
590	E:E:D98	E:E:T95	1.45	No	No	0	1	2
591	R:R:D103	R:R:T138	1.45	Yes	No	0	3	2
592	R:R:K340	R:R:K343	1.44	No	No	0	8	8
593	R:R:M367	R:R:N365	1.4	No	No	0	4	4
594	R:R:A136	R:R:F137	1.39	No	No	0	2	1
595	E:E:D74	E:E:N70	1.35	No	No	0	1	2
596	E:E:E143	E:E:L147	1.33	No	No	0	7	7
597	R:R:R321	R:R:V322	1.31	No	No	0	8	8
598	E:E:D77	E:E:E80	1.3	No	No	0	4	5
599	E:E:D170	R:R:E255	1.3	No	No	0	8	6
600	R:R:H336	R:R:L339	1.29	No	No	0	6	6
601	E:E:H71	E:E:N70	1.28	No	No	0	1	2
602	R:R:F225	R:R:I221	1.26	No	No	0	5	4
603	R:R:F39	R:R:L40	1.22	No	No	0	4	5
604	R:R:L62	R:R:R74	1.21	Yes	No	0	3	4
605	R:R:N73	R:R:R74	1.21	No	No	0	4	4
606	E:E:D170	R:R:R258	1.19	No	No	0	8	5
607	R:R:D83	R:R:R58	1.19	No	No	0	5	3
608	R:R:L90	R:R:Y111	1.17	No	No	0	4	4
609	E:E:N60	E:E:Y61	1.16	No	Yes	0	3	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	E:E:Y61	4.78	8	1	8
2	E:E:W69	3.992	5	1	6
3	E:E:Y72	6.89571	7	1	9
4	E:E:M76	8.146	5	1	9
5	E:E:W86	5.6075	4	0	9
6	E:E:P92	3.4625	4	1	6
7	E:E:Y93	6.03	4	1	9
8	E:E:R97	7.05375	8	1	7
9	E:E:L100	4.228	5	1	8
10	E:E:F111	5.94	6	1	8
11	E:E:N113	6.062	5	1	9
12	E:E:H124	8.156	5	1	9
13	E:E:H127	8.8825	4	1	8
14	E:E:P141	8.9775	4	0	9
15	E:E:I157	3.598	5	2	9
16	L:L:C2	5.4175	4	2	0
17	L:L:T6	5.624	5	2	0
18	L:L:Q10	5.8775	4	2	0
19	L:L:F15	7.468	5	0	0
20	L:L:L16	4.34	4	3	0
21	L:L:S20	5.41	4	3	0
22	L:L:T30	6.355	4	1	0
23	L:L:S34	5.765	4	6	0
24	L:L:Y37	5.82286	7	1	0
25	L:L:?38	5.315	4	1	0
26	R:R:K47	3.098	5	1	4
27	R:R:M49	5.658	5	1	4
28	R:R:Q52	8.118	5	1	6
29	R:R:Y56	8.27167	6	1	3
30	R:R:L62	4.415	4	0	3
31	R:R:W76	7.89	6	1	8
32	R:R:D77	5.825	6	1	9
33	R:R:G78	5.1775	4	1	5
34	R:R:W79	8.41667	6	1	6
35	R:R:L80	8.47	5	1	5
36	R:R:W82	7.97286	7	1	9
37	R:R:T85	4.8075	4	1	7
38	R:R:P96	8.49	4	1	9
39	R:R:Y98	5.785	6	1	4
40	R:R:F99	9.3925	4	1	5
41	R:R:F102	7.07	6	1	4
42	R:R:D103	4.938	5	0	3
43	R:R:E106	7.49	4	12	4
44	R:R:V108	5.98	4	1	7
45	R:R:K110	10.694	5	1	8
46	R:R:W118	9.844	5	1	9
47	R:R:H121	10.7525	4	6	4
48	R:R:W128	11.4075	4	0	5
49	R:R:S129	6.718	5	1	7
50	R:R:Y131	8.17	6	1	5
51	R:R:L148	4.8675	4	3	5
52	R:R:Y149	7.08	4	3	5
53	R:R:H156	7.4125	4	0	7
54	R:R:F170	6.252	5	0	8
55	R:R:F173	6.375	4	0	7
56	R:R:Q179	9.5175	4	0	7
57	R:R:L183	3.8925	4	2	8
58	R:R:H184	6.3875	4	0	9
59	R:R:F188	5.025	4	0	8
60	R:R:Y191	8.61	6	2	8
61	R:R:I198	4.4475	4	0	7
62	R:R:V206	3.5225	4	0	3
63	R:R:L211	4.7175	4	5	1
64	R:R:F224	4.3575	4	0	5
65	R:R:Q227	7.48	5	2	7
66	R:R:Y228	5.1575	4	2	8
67	R:R:M230	4.89	4	2	6
68	R:R:N233	8.8275	4	2	9
69	R:R:Y234	7.656	5	2	7
70	R:R:F235	5.52	4	2	5
71	R:R:W236	7.8	7	2	9
72	R:R:M237	4.59833	6	2	9
73	R:R:I242	4.985	4	0	7
74	R:R:Y243	9.01	4	2	8
75	R:R:L244	3.26	4	0	9
76	R:R:H245	10.49	4	14	8
77	R:R:V250	2.7075	4	0	5
78	R:R:Q257	5.155	4	0	5
79	R:R:L259	5.354	5	2	5
80	R:R:W261	5.9775	4	10	2
81	R:R:Y262	5.58	6	2	7
82	R:R:W267	7.036	5	2	9
83	R:R:F269	5.33857	7	2	3
84	R:R:P270	4.12333	6	2	9
85	R:R:P273	5.1625	4	2	6
86	R:R:R281	8.135	4	4	7
87	R:R:F285	6.96	5	4	6
88	R:R:W290	13.4	4	4	9
89	R:R:T295	8.1775	4	4	4
90	R:R:L297	5.2625	4	0	4
91	R:R:H302	6.24	5	2	6
92	R:R:P304	4.6575	4	2	9
93	R:R:F313	4.31	4	0	6
94	R:R:L316	3.9025	4	15	9
95	R:R:L352	4.504	5	15	9
96	R:R:I354	5.36	4	15	6
97	R:R:Q355	9.24	4	2	8
98	R:R:F356	6.34143	7	2	7
99	R:R:R362	6.5	5	7	4
100	R:R:P363	5.845	4	7	7
101	R:R:Y374	3.89	4	3	6
102	R:R:H377	7.965	4	3	7
103	R:R:H381	8.8275	4	0	9
104	R:R:Q383	8.83	4	2	9
105	R:R:F385	5.875	4	0	5
106	R:R:F393	5.3125	4	13	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	E:E:H124	R:R:Y56	13.9404	7.62	Yes	Yes	1	9	3
2	E:E:R97	R:R:M49	16.6149	7.44	Yes	Yes	1	7	4
3	E:E:Y93	R:R:M49	15.9679	3.59	Yes	Yes	1	9	4
4	E:E:R97	R:R:Q52	24.1013	10.51	Yes	Yes	1	7	6
5	E:E:Y93	R:R:Q52	15.7297	6.76	Yes	Yes	1	9	6
6	E:E:Y72	E:E:Y93	24.7892	3.97	Yes	Yes	1	9	9
7	E:E:D77	E:E:E80	10.2327	1.3	No	No	0	4	5
8	E:E:E80	E:E:W83	11.5093	8.72	No	No	0	5	7
9	E:E:H124	R:R:Y53	14.9573	5.44	Yes	No	1	9	1
10	E:E:W86	R:R:Y53	13.3	5.79	Yes	No	0	9	1
11	E:E:W86	R:R:D50	10.0051	4.47	Yes	No	0	9	2
12	R:R:W76	R:R:Y56	25.6696	10.61	Yes	Yes	1	8	3
13	E:E:F121	R:R:Y56	21.2668	10.32	No	Yes	0	6	3
14	E:E:F121	R:R:M59	17.7351	8.71	No	No	0	6	5
15	L:L:?38	L:L:Y37	76.8987	2.9	Yes	Yes	1	0	0
16	L:L:?38	R:R:W128	95.7209	11.28	Yes	Yes	0	0	5
17	R:R:N130	R:R:W128	97.6722	11.3	No	Yes	0	8	5
18	R:R:N130	R:R:T109	97.9894	5.85	No	No	0	8	5
19	R:R:K107	R:R:T109	98.1472	4.5	No	No	0	3	5
20	R:R:K107	R:R:M133	98.3043	5.76	No	No	0	3	5
21	R:R:E106	R:R:M133	98.4609	13.53	Yes	No	0	4	5
22	R:R:D103	R:R:E106	99.0862	5.2	Yes	Yes	0	3	4
23	R:R:D103	R:R:K141	99.8491	2.77	Yes	No	0	3	3
24	L:L:F15	R:R:K141	100	9.93	Yes	No	0	0	3
25	L:L:F15	L:L:S19	49.2223	13.21	Yes	No	0	0	0
26	L:L:S19	L:L:S20	49.2389	3.26	No	Yes	0	0	0
27	L:L:L23	L:L:S20	98.513	6.01	No	Yes	3	0	0
28	L:L:L23	R:R:Y149	83.4532	7.03	No	Yes	3	0	5
29	R:R:L202	R:R:Y149	85.9001	4.69	No	Yes	0	7	5
30	R:R:I198	R:R:L202	85.1432	2.85	Yes	No	0	7	7
31	R:R:H226	R:R:I198	27.4737	3.98	No	Yes	0	6	7
32	R:R:H226	R:R:Q227	26.0062	4.95	No	Yes	0	6	7
33	R:R:H223	R:R:Q227	10.15	12.36	No	Yes	0	5	7
34	L:L:F15	R:R:L142	49.3351	6.09	Yes	No	0	0	2
35	L:L:S20	R:R:L142	49.2386	6.01	Yes	No	3	0	2
36	R:R:R281	R:R:T295	11.2802	5.17	Yes	Yes	4	7	4
37	R:R:I198	R:R:N194	60.171	5.66	Yes	No	0	7	8
38	R:R:N194	R:R:N233	59.9821	9.54	No	Yes	0	8	9
39	R:R:N233	R:R:T190	28.2833	8.77	Yes	No	2	9	9
40	R:R:T190	R:R:W267	12.8551	3.64	No	Yes	2	9	9
41	R:R:C232	R:R:W267	12.4391	5.22	No	Yes	2	8	9
42	R:R:T190	R:R:W236	15.1113	6.06	No	Yes	2	9	9
43	R:R:L183	R:R:W236	11.9839	3.42	Yes	Yes	2	8	9
44	L:L:L16	L:L:L23	14.9653	5.54	Yes	No	3	0	0
45	R:R:M237	R:R:N233	18.8743	4.21	Yes	Yes	2	9	9
46	L:L:L16	R:R:V206	11.8288	2.98	Yes	Yes	0	0	3
47	L:L:Y37	R:R:W79	10.5013	12.54	Yes	Yes	1	0	6
48	R:R:M59	R:R:R74	16.5568	11.17	No	No	0	5	4
49	R:R:N233	R:R:Y191	25.9521	12.79	Yes	Yes	2	9	8
50	R:R:M187	R:R:Y191	13.8351	8.38	No	Yes	2	8	8
51	R:R:E240	R:R:M187	30.0411	12.18	No	No	0	9	8
52	R:R:M187	R:R:M237	16.7872	4.33	No	Yes	2	8	9
53	R:R:E240	R:R:L351	21.0535	6.63	No	No	0	9	9
54	R:R:V387	R:R:Y191	12.7815	6.31	No	Yes	0	9	8
55	R:R:F188	R:R:V387	12.4892	3.93	Yes	No	0	8	9
56	R:R:L351	R:R:L352	15.4222	4.15	No	Yes	0	9	9
57	E:E:R97	L:L:Y37	49.8659	4.12	Yes	Yes	1	7	0
58	R:R:G78	R:R:W76	18.8256	4.22	Yes	Yes	1	5	8
59	R:R:D77	R:R:G78	10.1486	3.35	Yes	Yes	1	9	5
60	L:L:?38	R:R:D77	12.6172	3.36	Yes	Yes	1	0	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
E:E:E101	E:E:R97	6.98	1	No	Yes	8	7	1	1
E:E:F111	E:E:R97	10.69	1	Yes	Yes	8	7	1	1
E:E:R97	L:L:Y37	4.12	1	Yes	Yes	7	0	1	0
E:E:R97	R:R:M48	8.69	1	Yes	No	7	6	1	2
E:E:R97	R:R:M49	7.44	1	Yes	Yes	7	4	1	2
E:E:R97	R:R:Q52	10.51	1	Yes	Yes	7	6	1	2
E:E:R97	R:R:W76	5	1	Yes	Yes	7	8	1	2
E:E:R97	R:R:G78	3	1	Yes	Yes	7	5	1	1
E:E:F111	E:E:L100	4.87	1	Yes	Yes	8	8	1	2
E:E:A116	E:E:L100	4.73	1	No	Yes	9	8	2	2
E:E:E101	E:E:F111	7	1	No	Yes	8	8	1	1
E:E:E101	L:L:Y37	3.37	1	No	Yes	8	0	1	0
E:E:F111	E:E:P112	7.22	1	Yes	No	8	9	1	2
E:E:A116	E:E:F111	2.77	1	No	Yes	9	8	2	1
E:E:F111	L:L:Y37	3.09	1	Yes	Yes	8	0	1	0
E:E:I150	R:R:Y299	3.63	0	No	No	9	7	2	1
L:L:K1	R:R:V293	4.55	0	No	No	0	6	0	1
L:L:C2	R:R:Y299	8.06	2	Yes	No	0	7	0	1
L:L:C2	R:R:H302	2.95	2	Yes	Yes	0	6	0	1
L:L:N3	R:R:W361	18.08	0	No	No	0	4	0	1
L:L:N3	R:R:R362	4.82	0	No	Yes	0	4	0	1
L:L:A5	R:R:F356	2.77	0	No	Yes	0	7	0	1
L:L:T6	R:R:Y234	7.49	2	Yes	Yes	0	7	0	1
L:L:T6	R:R:H302	8.21	2	Yes	Yes	0	6	0	1
L:L:T6	R:R:V305	4.76	2	Yes	No	0	7	0	1
L:L:T6	R:R:M306	4.52	2	Yes	No	0	4	0	1
L:L:C7	R:R:H302	7.37	2	No	Yes	0	6	0	1
L:L:A8	R:R:H377	4.39	0	No	Yes	0	7	0	1
L:L:Q10	R:R:Q227	6.4	2	Yes	Yes	0	7	0	1
L:L:Q10	R:R:M230	5.44	2	Yes	Yes	0	6	0	1
L:L:Q10	R:R:H302	7.42	2	Yes	Yes	0	6	0	1
L:L:L12	R:R:L148	2.77	3	No	Yes	0	5	0	1
L:L:L12	R:R:H377	6.43	3	No	Yes	0	7	0	1
L:L:A13	R:R:H201	2.93	0	No	No	0	6	0	1
L:L:N14	R:R:V293	7.39	0	No	No	0	6	0	1
L:L:F15	R:R:K141	9.93	0	Yes	No	0	3	0	1
L:L:F15	R:R:L142	6.09	0	Yes	No	0	2	0	1
L:L:F15	R:R:A145	2.77	0	Yes	No	0	4	0	1
L:L:L16	R:R:Y149	4.69	3	Yes	Yes	0	5	0	1
L:L:L16	R:R:V206	2.98	3	Yes	Yes	0	3	0	1
L:L:V17	R:R:V206	4.81	5	No	Yes	0	3	0	1
L:L:V17	R:R:V212	4.81	5	No	No	0	3	0	1
L:L:V17	R:R:L291	4.47	5	No	No	0	6	0	1
L:L:S20	R:R:L142	6.01	3	Yes	No	0	2	0	1
L:L:S20	R:R:Y146	6.36	3	Yes	No	0	2	0	1
L:L:N22	R:R:G209	5.09	0	No	No	0	3	0	1
L:L:L23	R:R:Y149	7.03	3	No	Yes	0	5	0	1
L:L:P29	R:R:D101	3.22	0	No	No	0	4	0	1
L:L:T30	R:R:F99	11.67	1	Yes	Yes	0	5	0	1
L:L:T30	R:R:D101	4.34	1	Yes	No	0	4	0	1
L:L:T30	R:R:F102	6.49	1	Yes	Yes	0	4	0	1
L:L:T30	R:R:N135	2.92	1	Yes	No	0	3	0	1
L:L:V32	R:R:N135	11.82	0	No	No	0	3	0	1
L:L:S34	R:R:H121	8.37	6	Yes	Yes	0	4	0	1
L:L:S34	R:R:E123	5.75	6	Yes	No	0	4	0	1
L:L:S34	R:R:N124	5.96	6	Yes	No	0	5	0	1
L:L:N35	R:R:N124	4.09	6	No	No	0	5	0	1
L:L:T36	R:R:W79	3.64	0	No	Yes	0	6	0	1
L:L:Y37	R:R:D77	4.6	1	Yes	Yes	0	9	0	1
L:L:Y37	R:R:G78	10.14	1	Yes	Yes	0	5	0	1
L:L:Y37	R:R:W79	12.54	1	Yes	Yes	0	6	0	1
L:L:?38	R:R:D77	3.36	1	Yes	Yes	0	9	0	1
L:L:?38	R:R:W128	11.28	1	Yes	Yes	0	5	0	1
L:L:?38	R:R:S129	3.72	1	Yes	Yes	0	7	0	1
R:R:M48	R:R:M49	4.33	1	No	Yes	6	4	2	2
R:R:M48	R:R:Y98	4.79	1	No	Yes	6	4	2	2
R:R:M49	R:R:Q52	6.8	1	Yes	Yes	4	6	2	2
R:R:Q52	R:R:W76	13.14	1	Yes	Yes	6	8	2	2
R:R:G78	R:R:W76	4.22	1	Yes	Yes	5	8	1	2
R:R:D77	R:R:G78	3.35	1	Yes	Yes	9	5	1	1
R:R:D77	R:R:W82	4.47	1	Yes	Yes	9	9	1	2
R:R:D77	R:R:S129	8.83	1	Yes	Yes	9	7	1	1
R:R:D77	R:R:Y131	10.34	1	Yes	Yes	9	5	1	2
R:R:W79	R:R:Y98	5.79	1	Yes	Yes	6	4	1	2
R:R:F99	R:R:W79	10.02	1	Yes	Yes	5	6	1	1
R:R:F102	R:R:W79	5.01	1	Yes	Yes	4	6	1	1
R:R:W79	R:R:Y131	13.5	1	Yes	Yes	6	5	1	2
R:R:K110	R:R:W82	16.24	1	Yes	Yes	8	9	2	2
R:R:S129	R:R:W82	3.71	1	Yes	Yes	7	9	1	2
R:R:P96	R:R:Y98	13.91	1	Yes	Yes	9	4	2	2
R:R:F102	R:R:P96	5.78	1	Yes	Yes	4	9	1	2
R:R:P96	R:R:Y131	2.78	1	Yes	Yes	9	5	2	2
R:R:F99	R:R:Y98	5.16	1	Yes	Yes	5	4	1	2
R:R:F102	R:R:F99	10.72	1	Yes	Yes	4	5	1	1
R:R:C134	R:R:F102	8.38	0	No	Yes	9	4	2	1
R:R:F102	R:R:N135	6.04	1	Yes	No	4	3	1	1
R:R:D103	R:R:K141	2.77	0	Yes	No	3	3	2	1
R:R:K110	R:R:S129	12.24	1	Yes	Yes	8	7	2	1
R:R:F119	R:R:W128	4.01	0	No	Yes	4	5	2	1
R:R:H121	R:R:P122	10.68	6	Yes	No	4	5	1	2
R:R:E123	R:R:H121	4.92	6	No	Yes	4	4	1	1
R:R:H121	R:R:W128	19.04	6	Yes	Yes	4	5	1	1
R:R:N124	R:R:R126	4.82	6	No	No	5	4	1	2
R:R:N130	R:R:W128	11.3	0	No	Yes	8	5	2	1
R:R:S129	R:R:Y131	5.09	1	Yes	Yes	7	5	1	2
R:R:L142	R:R:Y146	10.55	3	No	No	2	2	1	1
R:R:D373	R:R:L148	4.07	0	No	Yes	5	5	2	1
R:R:H377	R:R:L148	10.29	3	Yes	Yes	7	5	1	1
R:R:Y149	R:R:Y150	11.91	3	Yes	No	5	4	1	2
R:R:L202	R:R:Y149	4.69	0	No	Yes	7	5	2	1
R:R:H201	R:R:V205	9.69	0	No	No	6	7	1	2
R:R:H201	R:R:V206	2.77	0	No	Yes	6	3	1	1
R:R:P207	R:R:V206	3.53	0	No	Yes	3	3	2	1
R:R:C289	R:R:V212	6.83	5	No	No	9	3	2	1
R:R:L291	R:R:V212	2.98	5	No	No	6	3	1	1
R:R:H223	R:R:Q227	12.36	0	No	Yes	5	7	2	1
R:R:H226	R:R:Q227	4.95	0	No	Yes	6	7	2	1
R:R:M230	R:R:Q227	4.08	2	Yes	Yes	6	7	1	1
R:R:I301	R:R:Q227	9.61	0	No	Yes	7	7	2	1
R:R:M230	R:R:Y234	4.79	2	Yes	Yes	6	7	1	1
R:R:H302	R:R:M230	5.25	2	Yes	Yes	6	6	1	1
R:R:M237	R:R:Y234	4.79	2	Yes	Yes	9	7	2	1
R:R:V305	R:R:Y234	8.83	2	No	Yes	7	7	1	1
R:R:F356	R:R:Y234	12.38	2	Yes	Yes	7	7	1	1
R:R:L309	R:R:M237	2.83	0	No	Yes	7	9	2	2
R:R:M237	R:R:Q383	5.44	2	Yes	Yes	9	9	2	2
R:R:C289	R:R:L291	3.17	5	No	No	9	6	2	1
R:R:L298	R:R:V293	2.98	0	No	No	6	6	2	1
R:R:H296	R:R:Y299	3.27	0	No	No	2	7	2	1
R:R:F356	R:R:L309	3.65	2	Yes	No	7	7	1	2
R:R:G353	R:R:Q355	3.29	2	No	Yes	9	8	2	2
R:R:F356	R:R:G353	3.01	2	Yes	No	7	9	1	2
R:R:F356	R:R:Q355	12.88	2	Yes	Yes	7	8	1	2
R:R:Q355	R:R:Q383	12.8	2	Yes	Yes	8	9	2	2
R:R:F356	R:R:I380	5.02	2	Yes	No	7	6	1	2
R:R:F356	R:R:Q383	4.68	2	Yes	Yes	7	9	1	2
R:R:P363	R:R:R362	2.88	7	Yes	Yes	7	4	2	1
R:R:G369	R:R:R362	4.5	7	No	Yes	4	4	2	1
R:R:R362	R:R:Y372	7.2	7	Yes	No	4	7	1	2
R:R:D373	R:R:R362	13.1	0	No	Yes	5	4	2	1
R:R:G369	R:R:P363	6.09	7	No	Yes	4	7	2	2
R:R:P363	R:R:Y372	11.13	7	Yes	No	7	7	2	2
R:R:H377	R:R:H381	10.75	3	Yes	Yes	7	9	1	2
R:R:H381	R:R:I380	5.3	0	Yes	No	9	6	2	2
R:R:L148	R:R:Y374	2.34	3	Yes	Yes	5	6	1	2
R:R:G209	R:R:N208	1.7	0	No	No	3	3	1	2
R:R:M306	R:R:P360	1.68	0	No	No	4	5	1	2
R:R:D101	R:R:P100	1.61	0	No	No	4	4	1	2
R:R:G209	R:R:R213	1.5	0	No	No	3	2	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7TYX_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.77
Number of Linked Nodes	484
Number of Links	609
Number of Hubs	106
Number of Links mediated by Hubs	376
Number of Communities	15
Number of Nodes involved in Communities	155
Number of Links involved in Communities	235

Path Summary
Number Of Nodes in MetaPath	61
Number Of Links MetaPath	60
Number of Shortest Paths	485662
Length Of Smallest Path	3
Average Path Length	24.8492
Length of Longest Path	47
Minimum Path Strength	1.21
Average Path Strength	6.54869
Maximum Path Strength	24.835
Minimum Path Correlation	0.7
Average Path Correlation	0.964666
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	2.5
Average % Of Corr. Nodes	48.0909
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	51.2138
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• molecular transducer activity • coreceptor activity • signaling receptor activity • calcitonin family binding • amide binding • binding • adrenomedullin binding • peptide hormone binding • hormone binding • calcitonin family receptor activity • peptide receptor activity • adrenomedullin receptor activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • transmembrane signaling receptor activity • developmental process • heart development • multicellular organism development • multicellular organismal process • anatomical structure development • animal organ development • circulatory system development • system development • system process • circulatory system process • regulation of blood pressure • biological regulation • regulation of biological quality • blood circulation
Gene Ontology	Biological Process	• developmental process • heart development • multicellular organism development • multicellular organismal process • anatomical structure development • animal organ development • circulatory system development • system development • system process • circulatory system process • regulation of blood pressure • biological regulation • regulation of biological quality • blood circulation • localization • import into cell • receptor internalization • transport • cellular process • receptor-mediated endocytosis • endocytosis • establishment of localization • vesicle-mediated transport • blood vessel morphogenesis • tube development • angiogenesis • vasculature development • anatomical structure morphogenesis • tube morphogenesis • anatomical structure formation involved in morphogenesis • blood vessel development • regulation of biosynthetic process • regulation of biological process • regulation of cellular process • positive regulation of biological process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • positive regulation of macromolecule biosynthetic process • regulation of gene expression • positive regulation of metabolic process • biosynthetic process • positive regulation of gene expression • positive regulation of biosynthetic process • regulation of macromolecule biosynthetic process • metabolic process • positive regulation of macromolecule metabolic process • macromolecule metabolic process • regulation of metabolic process • positive regulation of cellular process • regulation of developmental process • cellular developmental process • regulation of vasculogenesis • regulation of cell differentiation • vasculogenesis • positive regulation of developmental process • positive regulation of cell differentiation • cell differentiation • positive regulation of vasculogenesis • protein localization • establishment of protein localization • cellular localization • nitrogen compound transport • protein transport • cellular macromolecule localization • macromolecule localization • smooth muscle cell differentiation • cell development • muscle cell differentiation • muscle structure development • vascular associated smooth muscle cell differentiation • muscle cell development • vascular associated smooth muscle cell development • protein localization to cell periphery • protein localization to plasma membrane • localization within membrane • protein localization to membrane • cellular response to stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to stimulus • response to hormone • response to endogenous stimulus • response to chemical • cellular response to hormone stimulus • sprouting angiogenesis • negative regulation of vascular permeability • regulation of vascular permeability • vascular process in circulatory system • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • bicellular tight junction assembly • tight junction organization • apical junction assembly • cellular component organization • cellular component biogenesis • cell junction organization • cellular component assembly • cell junction assembly • tight junction assembly • cellular component organization or biogenesis • cell-cell junction assembly • cell-cell junction organization • intracellular transport • establishment of localization in cell • intracellular protein transport • regulation of signaling • regulation of signal transduction • regulation of response to stimulus • regulation of cell communication • regulation of G protein-coupled receptor signaling pathway • adrenomedullin receptor signaling pathway • calcitonin family receptor signaling pathway • regulation of vasculature development • regulation of multicellular organismal process • regulation of anatomical structure morphogenesis • regulation of multicellular organismal development • positive regulation of angiogenesis • positive regulation of vasculature development • regulation of angiogenesis • positive regulation of multicellular organismal process • extracellular matrix organization • basement membrane assembly • extracellular matrix assembly • basement membrane organization • extracellular structure organization • external encapsulating structure organization • amylin receptor signaling pathway • amylin receptor 2 signaling pathway • monoatomic ion transport • monoatomic cation transport • calcium ion transport • metal ion transport • negative regulation of endothelial cell apoptotic process • negative regulation of programmed cell death • regulation of apoptotic process • negative regulation of biological process • regulation of programmed cell death • cell death • negative regulation of apoptotic process • negative regulation of cellular process • endothelial cell apoptotic process • apoptotic process • programmed cell death • regulation of endothelial cell apoptotic process • adherens junction organization • adherens junction assembly • cellular response to growth factor stimulus • cellular response to vascular endothelial growth factor stimulus • response to growth factor • cellular anatomical structure • clathrin-coated pit • membrane • endomembrane system • cell surface • cell periphery • plasma membrane • intracellular anatomical structure • cytoplasm • protein-containing complex • plasma membrane protein complex • membrane protein complex • receptor complex • G protein-coupled receptor dimeric complex
Gene Ontology	Cellular Component	• cellular anatomical structure • clathrin-coated pit • membrane • endomembrane system • cell surface • cell periphery • plasma membrane • intracellular anatomical structure • cytoplasm • protein-containing complex • plasma membrane protein complex • membrane protein complex • receptor complex • G protein-coupled receptor dimeric complex • adrenomedullin receptor complex • plasma membrane signaling receptor complex • G protein-coupled receptor complex • calcitonin family receptor complex • membrane-bounded organelle • intracellular organelle • organelle • lytic vacuole • vacuole • intracellular membrane-bounded organelle • lysosome • protein binding • binding • signaling receptor binding • molecular transducer activity • molecular function activator activity • signaling receptor activity • molecular function regulator activity • signaling receptor regulator activity • receptor ligand activity • signaling receptor activator activity • hormone activity • lipid binding • identical protein binding • cellular response to stimulus • positive regulation of cell communication • regulation of cellular process • positive regulation of signal transduction • response to stimulus • signaling • positive regulation of biological process • regulation of signal transduction • intracellular signal transduction • cell communication • positive regulation of response to stimulus • regulation of intracellular signal transduction • intracellular signaling cassette • regulation of calcium-mediated signaling • positive regulation of calcium-mediated signaling • signal transduction • positive regulation of cellular process • regulation of biological process • regulation of signaling • biological regulation • positive regulation of intracellular signal transduction • regulation of response to stimulus • calcium-mediated signaling • regulation of cell communication • cellular process • positive regulation of signaling • behavior • multicellular organismal process • eating behavior • feeding behavior • amylin receptor 1 signaling pathway • amylin receptor signaling pathway • calcitonin family receptor signaling pathway • G protein-coupled receptor signaling pathway • myeloid leukocyte differentiation • regulation of leukocyte differentiation • cellular developmental process • regulation of developmental process • negative regulation of biological process • cell development • regulation of cell differentiation • regulation of cell development • regulation of osteoclast differentiation • multicellular organism development • cell differentiation • osteoclast differentiation • anatomical structure development • negative regulation of cellular process • regulation of immune system process • regulation of multicellular organismal process • negative regulation of cell differentiation • negative regulation of hemopoiesis • developmental process • regulation of multicellular organismal development • negative regulation of leukocyte differentiation • hemopoiesis • regulation of myeloid cell differentiation • negative regulation of developmental process • regulation of myeloid leukocyte differentiation • negative regulation of myeloid cell differentiation • negative regulation of osteoclast differentiation • negative regulation of myeloid leukocyte differentiation • negative regulation of cell development • myeloid cell differentiation • negative regulation of immune system process • immune system process • regulation of hemopoiesis • negative regulation of multicellular organismal process • leukocyte differentiation • monosaccharide metabolic process • carbohydrate metabolic process • hexose metabolic process • small molecule metabolic process • metabolic process • primary metabolic process • glucose metabolic process • negative regulation of tissue remodeling • homeostatic process • negative regulation of bone remodeling • regulation of bone remodeling • tissue homeostasis • regulation of tissue remodeling • regulation of bone resorption • bone resorption • negative regulation of bone resorption • multicellular organismal-level homeostasis • tissue remodeling • bone remodeling • anatomical structure homeostasis • amylin receptor 2 signaling pathway • system process • sensory perception • nervous system process • sensory perception of pain • positive regulation of cAMP/PKA signal transduction • cAMP/PKA signal transduction • regulation of cAMP/PKA signal transduction • amylin receptor 3 signaling pathway • intracellular vesicle • cytoplasmic vesicle • secretory granule • secretory vesicle • vesicle • somatodendritic compartment • cell body • neuronal cell body • extracellular region • extracellular space • amide binding • amyloid-beta binding • peptide binding • calcitonin family receptor activity • peptide receptor activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • transmembrane signaling receptor activity • calcitonin receptor activity • amylin receptor activity • calcitonin gene-related peptide receptor activity • calcitonin binding • calcitonin family binding • peptide hormone binding • hormone binding • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • catabolic process • RNA metabolic process • macromolecule catabolic process • regulation of primary metabolic process • nucleobase-containing compound metabolic process • post-transcriptional regulation of gene expression • regulation of RNA metabolic process • regulation of mRNA catabolic process • regulation of nucleobase-containing compound metabolic process • RNA catabolic process • negative regulation of macromolecule metabolic process • regulation of biosynthetic process • mRNA catabolic process • negative regulation of metabolic process • regulation of macromolecule metabolic process • regulation of catabolic process • gene expression • mRNA metabolic process • macromolecule biosynthetic process • nucleic acid metabolic process • nucleobase-containing compound catabolic process • regulation of mRNA stability • regulation of gene expression • negative regulation of gene expression • biosynthetic process • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • regulation of RNA stability • nucleic acid catabolic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • regulation of mRNA metabolic process • regulation of metabolic process • positive regulation of ERK1 and ERK2 cascade • positive regulation of MAPK cascade • regulation of MAPK cascade • MAPK cascade • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of macromolecule biosynthetic process • positive regulation of metabolic process • positive regulation of gene expression • positive regulation of biosynthetic process • positive regulation of macromolecule metabolic process • regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • phosphatidylinositol 3-kinase/protein kinase B signal transduction • response to corticosteroid • response to lipid • response to hormone • response to steroid hormone • response to chemical • response to endogenous stimulus • response to glucocorticoid • adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • response to amyloid-beta • cell surface receptor signaling pathway • calcitonin gene-related peptide receptor signaling pathway • ossification • regulation of ossification • negative regulation of ossification • cell projection • cilium • plasma membrane bounded cell projection • amylin receptor complex • amylin receptor complex 3 • amylin receptor complex 2 • amylin receptor complex 1 • axon • neuron projection • acrosomal vesicle • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • phosphorus-oxygen lyase activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • adenylate cyclase activator activity • adenylate cyclase activity • cation binding • metal ion binding • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • sensory perception of chemical stimulus • sensory perception of smell • cellular response to nitrogen compound • response to peptide hormone • cellular response to peptide hormone stimulus • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • cellular response to hormone stimulus • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • adaptive thermogenesis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • protein localization • regulation of localization • establishment of protein localization • nitrogen compound transport • localization • cellular macromolecule localization • regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • protein transport • regulation of cellular localization • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • inflammatory response to antigenic stimulus • regulation of response to stress • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • extrinsic component of plasma membrane • catalytic complex • cytoplasmic side of membrane • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular membrane-bounded organelle • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • trans-Golgi network • organelle membrane • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of taste • sensory organ development • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • cell population proliferation • small GTPase-mediated signal transduction • Ras protein signal transduction • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • vacuolar membrane • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation
SCOP2	Domain Identifier	• RAMP1-like • G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• RAMP1-like • G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	NH2
PDB Residues	L:L:?38
Environment Details	Open EMBL-EBI Page
Code	NH2
Name	AMINO GROUP
Synonyms
Identifier
Formula	H2 N
Molecular Weight	16.023
SMILES
PubChem	123329
Formal Charge	0
Total Atoms	3
Total Chiral Atoms	0
Total Bonds	2
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	E
Protein	RAMP2
UniProt	O60895
Sequence	>7TYX_nogp_Chain_E N Y E T A V Q F C W N H Y K D Q M D P I E K D W C D W A M I S R P Y S T L R D C L E H F A E L F D L G F P N P L A E R I I F E T H Q I H F A N C S L V Q P T F S D P P E D V L L A M I I A P I C L I P F L I T L V V W R S K D S Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	R
Protein	Receptor
UniProt	P30988
Sequence	>7TYX_nogp_Chain_R F L Y V V G R K K M M D A Q Y K C Y D R M Q Q L P A Y Q G E G P Y C N R T W D G W L C W D D T P A G V L S Y Q F C P D Y F P D F D P S E K V T K Y C D V W F K H P E N N R T W S N Y T M C N A F T P E K L K N A Y V L Y Y L A I V G H S L S I F T L V I S L G I F V F F R S L G C Q R V T L H K N M F L T Y I L N S M I I I I H L V E V V P N G E L V R R D P V S C K I L H F F H Q Y M M A C N Y F W M L C E G I Y L H T L I V V A V F T E K Q R L R W Y Y L L G W G F P L V P T T I H A I T R A V Y F N D N C W L S V E T H L L Y I I H G P V M A A L V V N F F F L L N I V R V L V T K M R E T H E A E S H M Y L K A V K A T M I L V P L L G I Q F V V F P W R P S N K M L G K I Y D Y V M H S L I H F Q G F F V A T I Y C F C N N E V Q T T V K R Q W Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7TYX	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Amylin	-	Gs/β1/γ2; RAMP2	2.55	2022-03-30	10.1126/science.abm9609
	7TYX (No Gprot)	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Amylin	-		2.55	2022-03-30	10.1126/science.abm9609
	7TYY	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Calcitonin-1	-	Gs/β1/γ2; RAMP2	3	2022-03-23	10.1126/science.abm9609
	7TYY (No Gprot)	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Calcitonin-1	-		3	2022-03-23	10.1126/science.abm9609
	7TYH	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Calcitonin-1	-	Gs/β1/γ2; RAMP2	3.3	2022-03-23	10.1126/science.abm9609
	7TYH (No Gprot)	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Calcitonin-1	-		3.3	2022-03-23	10.1126/science.abm9609

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