psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	E:E:F107	E:E:N60	3.62	No	No	0	5	3
2	E:E:A104	E:E:Y61	4	No	Yes	5	9	8
3	E:E:L109	E:E:Y61	7.03	No	Yes	5	7	8
4	E:E:N113	E:E:Y61	10.47	Yes	Yes	5	9	8
5	E:E:L115	E:E:Y61	4.69	No	Yes	5	4	8
6	E:E:E62	E:E:L115	3.98	No	No	0	3	4
7	E:E:A64	E:E:F103	9.71	No	No	0	3	1
8	E:E:N70	E:E:Q66	11.88	No	No	0	2	4
9	E:E:F67	E:E:N70	3.62	No	No	0	1	2
10	E:E:C68	E:E:C99	7.28	No	No	0	9	9
11	E:E:C68	E:E:L100	4.76	No	No	0	9	8
12	E:E:W69	E:E:Y72	7.72	Yes	Yes	3	6	9
13	E:E:K73	E:E:W69	8.12	No	Yes	0	5	6
14	E:E:T123	E:E:W69	6.06	No	Yes	3	8	6
15	E:E:H127	E:E:W69	4.23	Yes	Yes	3	8	6
16	E:E:M76	E:E:Y72	7.18	No	Yes	3	9	9
17	E:E:L96	E:E:Y72	17.58	No	Yes	0	8	9
18	E:E:T123	E:E:Y72	4.99	No	Yes	3	8	9
19	E:E:H127	E:E:Y72	6.53	Yes	Yes	3	8	9
20	E:E:P92	E:E:Q75	7.9	No	No	0	6	3
21	E:E:M76	E:E:W83	12.8	No	No	3	9	7
22	E:E:H127	E:E:M76	9.19	Yes	No	3	8	9
23	E:E:D77	E:E:P78	8.05	No	No	0	4	5
24	E:E:D82	E:E:I79	5.6	No	No	0	6	7
25	E:E:I79	E:E:W83	8.22	No	No	0	7	7
26	E:E:D82	E:E:D85	5.32	No	No	0	6	7
27	E:E:D82	E:E:M88	4.16	No	No	0	6	5
28	E:E:H127	E:E:W83	13.75	Yes	No	3	8	7
29	E:E:C131	E:E:C84	7.28	No	No	0	9	9
30	E:E:A87	E:E:D85	4.63	No	No	0	5	7
31	E:E:S90	E:E:W86	7.41	No	No	0	7	9
32	E:E:W86	R:R:Y53	6.75	No	No	0	9	1
33	E:E:F128	E:E:I89	7.54	Yes	No	0	9	8
34	E:E:H124	E:E:Y93	8.71	No	No	0	9	9
35	E:E:Y93	R:R:M49	3.59	No	No	0	9	4
36	E:E:Y93	R:R:Q52	7.89	No	No	0	9	6
37	E:E:D98	E:E:S94	4.42	No	No	0	1	8
38	E:E:F111	E:E:R97	4.28	Yes	Yes	0	8	7
39	E:E:R97	R:R:M48	8.69	Yes	No	0	7	6
40	E:E:R97	R:R:M49	8.69	Yes	No	0	7	4
41	E:E:R97	R:R:Q52	11.68	Yes	No	0	7	6
42	E:E:D98	R:R:R45	7.15	No	No	0	1	7
43	E:E:E101	E:E:F111	5.83	No	Yes	0	8	8
44	E:E:E105	E:E:H102	4.92	No	No	0	5	1
45	E:E:A104	E:E:L109	4.73	No	No	5	9	7
46	E:E:E105	E:E:L106	3.98	No	No	0	5	1
47	E:E:F107	E:E:L106	4.87	No	No	0	5	1
48	E:E:L109	E:E:N113	6.87	No	Yes	5	7	9
49	E:E:G110	L:L:N35	5.09	No	No	0	5	0
50	E:E:F111	E:E:P112	5.78	Yes	No	0	8	9
51	E:E:A116	E:E:F111	4.16	No	Yes	0	9	8
52	E:E:P112	R:R:R126	4.32	No	No	0	9	4
53	E:E:L115	E:E:N113	4.12	No	Yes	5	4	9
54	E:E:A116	E:E:N113	4.69	No	Yes	0	9	9
55	E:E:E117	R:R:Y56	6.73	No	Yes	0	8	3
56	E:E:I120	R:R:Y56	13.3	No	Yes	0	9	3
57	E:E:F121	E:E:Q125	10.54	No	No	7	6	5
58	E:E:F121	R:R:Q60	4.68	No	No	7	6	3
59	E:E:F128	E:E:H124	6.79	Yes	No	0	9	9
60	E:E:H124	R:R:Y56	8.71	No	Yes	0	9	3
61	E:E:Q125	R:R:Q60	11.52	No	No	7	5	3
62	E:E:H127	E:E:I126	10.61	Yes	No	0	8	5
63	E:E:F128	E:E:H127	3.39	Yes	Yes	0	9	8
64	E:E:F128	R:R:Y53	8.25	Yes	No	0	9	1
65	E:E:L133	R:R:K54	8.46	No	No	0	4	4
66	E:E:L133	R:R:D57	13.57	No	No	0	4	4
67	E:E:P136	R:R:K54	3.35	No	No	0	6	4
68	E:E:F138	E:E:T137	12.97	No	No	0	4	6
69	E:E:F138	R:R:F285	21.43	No	No	0	4	6
70	E:E:D140	E:E:P141	4.83	No	Yes	0	9	9
71	E:E:D140	R:R:H296	6.3	No	No	0	9	2
72	E:E:L146	E:E:P141	9.85	No	Yes	0	8	9
73	E:E:P141	R:R:Y284	11.13	Yes	No	0	9	2
74	E:E:P141	R:R:L297	3.28	Yes	No	0	9	4
75	E:E:P142	E:E:V145	5.3	No	No	0	9	7
76	E:E:I150	E:E:L146	4.28	No	No	0	9	8
77	E:E:M149	R:R:T280	6.02	No	No	0	9	4
78	E:E:M149	R:R:I300	4.37	No	No	0	9	8
79	E:E:I154	R:R:P304	5.08	No	Yes	0	9	9
80	E:E:L156	R:R:F269	4.87	No	Yes	0	9	3
81	E:E:I157	E:E:P158	3.39	No	No	0	9	9
82	E:E:I157	R:R:F269	5.02	No	Yes	0	9	3
83	E:E:L160	R:R:L265	4.15	No	No	0	9	7
84	E:E:T162	E:E:W166	4.85	No	No	0	8	8
85	E:E:L163	R:R:W261	9.11	No	Yes	0	9	2
86	E:E:V164	R:R:Y262	6.31	No	No	0	9	7
87	E:E:V165	E:E:W166	3.68	No	No	0	9	8
88	E:E:S168	R:R:W261	6.18	No	Yes	0	9	2
89	E:E:D170	E:E:K169	4.15	No	No	0	8	9
90	L:L:?0	L:L:?101	19.79	No	No	8	0	0
91	L:L:?0	R:R:H296	3.46	No	No	8	0	2
92	L:L:?0	R:R:Y299	9.45	No	No	0	0	7
93	L:L:K1	R:R:F94	7.44	No	No	0	0	3
94	L:L:K1	R:R:E294	8.1	No	No	0	0	3
95	L:L:C2	L:L:C7	7.28	No	No	0	0	0
96	L:L:C2	R:R:V293	3.42	No	No	0	0	6
97	L:L:C2	R:R:L298	4.76	No	No	0	0	6
98	L:L:N3	L:L:R11	3.62	No	No	2	0	0
99	L:L:N3	R:R:W361	19.21	No	No	0	0	4
100	L:L:N3	R:R:R362	3.62	No	Yes	2	0	4
101	L:L:T4	L:L:T6	4.71	No	Yes	0	0	0
102	L:L:T4	R:R:M306	4.52	No	No	0	0	4
103	L:L:T6	R:R:Y234	8.74	Yes	Yes	2	0	7
104	L:L:T6	R:R:H302	6.85	Yes	No	0	0	6
105	L:L:T6	R:R:F356	5.19	Yes	Yes	2	0	7
106	L:L:C7	L:L:R11	4.18	No	No	0	0	0
107	L:L:A8	R:R:H377	4.39	No	Yes	0	0	7
108	L:L:Q10	R:R:H201	4.95	No	Yes	0	0	6
109	L:L:R11	R:R:R362	4.26	No	Yes	2	0	4
110	L:L:L12	R:R:L148	5.54	No	No	4	0	5
111	L:L:L12	R:R:H377	6.43	No	Yes	4	0	7
112	L:L:E14	L:L:R17	10.47	No	No	0	0	0
113	L:L:E14	R:R:V293	5.7	No	No	0	0	6
114	L:L:F15	L:L:S19	7.93	No	No	0	0	0
115	L:L:F15	R:R:K141	13.65	No	No	0	0	3
116	L:L:F15	R:R:L142	3.65	No	No	0	0	2
117	L:L:L16	R:R:Y149	3.52	No	Yes	0	0	5
118	L:L:H18	L:L:S19	6.97	No	No	0	0	0
119	L:L:H18	R:R:D97	7.56	No	No	0	0	2
120	L:L:S20	R:R:Y146	5.09	No	No	0	0	2
121	L:L:L27	L:L:N21	8.24	No	No	0	0	0
122	L:L:F23	R:R:Y146	7.22	No	No	0	0	2
123	L:L:G24	L:L:P25	4.06	No	No	0	0	0
124	L:L:T30	R:R:F99	16.86	No	Yes	1	0	5
125	L:L:T30	R:R:D101	10.12	No	Yes	1	0	4
126	L:L:T30	R:R:F102	3.89	No	Yes	1	0	4
127	L:L:G33	L:L:N31	3.39	No	No	1	0	0
128	L:L:N31	L:L:T36	5.85	No	Yes	1	0	0
129	L:L:V32	R:R:Y131	5.05	No	Yes	0	0	5
130	L:L:V32	R:R:N135	4.43	No	No	0	0	3
131	L:L:G33	L:L:T36	3.64	No	Yes	1	0	0
132	L:L:S34	R:R:H121	8.37	No	Yes	11	0	4
133	L:L:S34	R:R:N124	10.43	No	Yes	11	0	5
134	L:L:P37	L:L:T36	5.25	No	Yes	1	0	0
135	L:L:?38	L:L:T36	3.65	Yes	Yes	1	0	0
136	L:L:?38	L:L:P37	12.19	Yes	No	1	0	0
137	L:L:P37	R:R:W79	25.67	No	Yes	1	0	6
138	L:L:?38	R:R:W128	5.64	Yes	Yes	0	0	5
139	L:L:?38	R:R:S129	3.72	Yes	Yes	1	0	7
140	L:L:?38	R:R:Y131	5.8	Yes	Yes	1	0	5
141	L:L:?101	R:R:H296	6.15	No	No	8	0	2
142	R:R:L40	R:R:P100	3.28	No	No	0	5	4
143	R:R:K47	R:R:Y98	3.58	No	Yes	0	4	4
144	R:R:M48	R:R:Y98	13.17	No	Yes	0	6	4
145	R:R:D50	R:R:K54	5.53	No	No	0	2	4
146	R:R:Q52	R:R:W76	14.24	No	Yes	0	6	8
147	R:R:C55	R:R:W76	10.45	No	Yes	12	9	8
148	R:R:C55	R:R:C81	7.28	No	No	12	9	9
149	R:R:W76	R:R:Y56	10.61	Yes	Yes	0	8	3
150	R:R:D57	R:R:Q61	3.92	No	No	0	4	3
151	R:R:Q61	R:R:R58	22.2	No	No	0	3	3
152	R:R:L62	R:R:R58	3.64	No	No	0	3	3
153	R:R:M59	R:R:R74	12.41	No	Yes	0	5	4
154	R:R:L62	R:R:R74	4.86	No	Yes	0	3	4
155	R:R:C112	R:R:C72	7.28	No	No	1	9	9
156	R:R:C72	R:R:W118	14.37	No	Yes	1	9	9
157	R:R:D83	R:R:R74	8.34	No	Yes	0	5	4
158	R:R:D84	R:R:R74	13.1	No	Yes	0	4	4
159	R:R:T75	R:R:W118	6.06	No	Yes	0	5	9
160	R:R:G78	R:R:W76	8.44	No	Yes	0	5	8
161	R:R:C81	R:R:W76	3.92	No	Yes	12	9	8
162	R:R:D77	R:R:W82	11.17	No	Yes	1	9	9
163	R:R:D77	R:R:S129	5.89	No	Yes	1	9	7
164	R:R:D77	R:R:Y131	6.9	No	Yes	1	9	5
165	R:R:W79	R:R:Y98	4.82	Yes	Yes	1	6	4
166	R:R:F99	R:R:W79	9.02	Yes	Yes	1	5	6
167	R:R:W79	R:R:Y131	16.4	Yes	Yes	1	6	5
168	R:R:L80	R:R:W82	3.42	Yes	Yes	1	5	9
169	R:R:L80	R:R:Q93	14.64	Yes	No	1	5	6
170	R:R:L80	R:R:P96	6.57	Yes	No	0	5	9
171	R:R:L80	R:R:Y131	7.03	Yes	Yes	1	5	5
172	R:R:S91	R:R:W82	4.94	No	Yes	0	5	9
173	R:R:Q93	R:R:W82	5.48	No	Yes	1	6	9
174	R:R:K110	R:R:W82	29.01	No	Yes	1	8	9
175	R:R:S129	R:R:W82	3.71	Yes	Yes	1	7	9
176	R:R:C112	R:R:T85	3.38	No	No	1	9	7
177	R:R:T85	R:R:W118	6.06	No	Yes	1	7	9
178	R:R:P86	R:R:V89	8.84	No	No	0	2	5
179	R:R:G88	R:R:Y111	4.35	No	No	0	8	4
180	R:R:L90	R:R:Y92	5.86	No	No	13	4	4
181	R:R:L90	R:R:T109	5.9	No	No	13	4	5
182	R:R:L90	R:R:Y111	7.03	No	No	0	4	4
183	R:R:K107	R:R:Y92	8.36	No	No	0	3	4
184	R:R:T109	R:R:Y92	6.24	No	No	13	5	4
185	R:R:F94	R:R:K107	3.72	No	No	0	3	3
186	R:R:C95	R:R:V108	3.42	No	No	0	9	7
187	R:R:C134	R:R:C95	7.28	No	No	0	9	9
188	R:R:P96	R:R:Y98	15.3	No	Yes	0	9	4
189	R:R:F102	R:R:P96	5.78	Yes	No	0	4	9
190	R:R:F99	R:R:Y98	6.19	Yes	Yes	1	5	4
191	R:R:D101	R:R:F99	3.58	Yes	Yes	1	4	5
192	R:R:F102	R:R:F99	10.72	Yes	Yes	1	4	5
193	R:R:D101	R:R:F102	3.58	Yes	Yes	1	4	4
194	R:R:D101	R:R:N135	8.08	Yes	No	1	4	3
195	R:R:C134	R:R:F102	12.57	No	Yes	0	9	4
196	R:R:F102	R:R:N135	8.46	Yes	No	1	4	3
197	R:R:D103	R:R:S105	10.31	No	No	0	3	1
198	R:R:D103	R:R:E106	5.2	No	No	0	3	4
199	R:R:E106	R:R:F137	7	No	Yes	14	4	1
200	R:R:E106	R:R:K366	5.4	No	No	14	4	3
201	R:R:V108	R:R:Y131	13.88	No	Yes	0	7	5
202	R:R:N130	R:R:T109	4.39	No	No	0	8	5
203	R:R:K110	R:R:W118	10.44	No	Yes	1	8	9
204	R:R:K110	R:R:S129	7.65	No	Yes	1	8	7
205	R:R:C112	R:R:W118	3.92	No	Yes	1	9	9
206	R:R:T127	R:R:W118	4.85	No	Yes	0	4	9
207	R:R:F119	R:R:W128	6.01	No	Yes	0	4	5
208	R:R:H121	R:R:P122	7.63	Yes	No	0	4	5
209	R:R:H121	R:R:N124	3.83	Yes	Yes	11	4	5
210	R:R:H121	R:R:W128	11.64	Yes	Yes	0	4	5
211	R:R:E123	R:R:N124	3.94	No	Yes	0	4	5
212	R:R:N124	R:R:R126	7.23	Yes	No	0	5	4
213	R:R:N130	R:R:W128	9.04	No	Yes	0	8	5
214	R:R:S129	R:R:Y131	6.36	Yes	Yes	1	7	5
215	R:R:N130	R:R:T132	4.39	No	No	0	8	6
216	R:R:A136	R:R:F137	8.32	No	Yes	0	2	1
217	R:R:F137	R:R:K366	11.17	Yes	No	14	1	3
218	R:R:P139	R:R:T138	3.5	No	No	0	3	2
219	R:R:L142	R:R:Y146	7.03	No	No	0	2	2
220	R:R:K370	R:R:N144	4.2	No	No	4	4	4
221	R:R:N144	R:R:Y374	5.81	No	Yes	4	4	6
222	R:R:H377	R:R:L148	14.14	Yes	No	4	7	5
223	R:R:Y149	R:R:Y150	3.97	Yes	No	0	5	4
224	R:R:I153	R:R:Y149	10.88	No	Yes	0	7	5
225	R:R:L202	R:R:Y149	7.03	No	Yes	0	7	5
226	R:R:A152	R:R:H381	7.32	No	Yes	0	7	9
227	R:R:G155	R:R:V154	3.68	No	No	0	8	6
228	R:R:F382	R:R:G155	6.02	No	No	0	7	8
229	R:R:H156	R:R:S195	9.76	Yes	No	0	7	7
230	R:R:H156	R:R:I198	10.61	Yes	Yes	0	7	7
231	R:R:H156	R:R:I199	3.98	Yes	No	0	7	7
232	R:R:H156	R:R:H381	4.78	Yes	Yes	0	7	9
233	R:R:F385	R:R:L158	6.09	No	No	0	5	4
234	R:R:G384	R:R:S159	3.71	No	No	0	9	9
235	R:R:I160	R:R:I192	4.42	No	No	0	5	7
236	R:R:I160	R:R:S195	6.19	No	No	0	5	7
237	R:R:F161	R:R:I165	5.02	No	No	0	4	5
238	R:R:F385	R:R:T162	7.78	No	No	0	5	6
239	R:R:A388	R:R:T162	3.36	No	No	0	8	6
240	R:R:F188	R:R:L163	6.09	No	No	0	8	8
241	R:R:I192	R:R:L163	4.28	No	No	0	7	8
242	R:R:F393	R:R:I165	3.77	No	No	0	8	5
243	R:R:A388	R:R:S166	3.42	No	No	0	8	9
244	R:R:C392	R:R:S166	6.89	No	No	0	9	9
245	R:R:F393	R:R:S166	3.96	No	No	0	8	9
246	R:R:F188	R:R:L167	3.65	No	No	0	8	6
247	R:R:F170	R:R:V181	6.55	No	No	0	8	9
248	R:R:F170	R:R:H184	5.66	No	Yes	0	8	9
249	R:R:F170	R:R:K185	3.72	No	No	0	8	6
250	R:R:F172	R:R:F173	15	No	Yes	0	2	7
251	R:R:F173	R:R:L176	3.65	Yes	No	0	7	9
252	R:R:F173	R:R:T401	5.19	Yes	No	0	7	7
253	R:R:F173	R:R:V402	3.93	Yes	No	0	7	5
254	R:R:C178	R:R:V181	3.42	No	No	0	8	9
255	R:R:Q179	R:R:Y243	6.76	No	Yes	0	7	8
256	R:R:K256	R:R:Q179	5.42	No	No	0	5	7
257	R:R:L259	R:R:Q179	3.99	No	No	0	5	7
258	R:R:H184	R:R:R180	10.16	Yes	No	0	9	9
259	R:R:E240	R:R:L183	5.3	No	No	0	9	8
260	R:R:L183	R:R:Y243	4.69	No	Yes	0	8	8
261	R:R:E240	R:R:H184	11.08	No	Yes	0	9	9
262	R:R:H184	R:R:Y391	5.44	Yes	No	0	9	8
263	R:R:N186	R:R:W236	13.56	No	Yes	2	9	9
264	R:R:N186	R:R:Y263	5.81	No	No	2	9	5
265	R:R:M187	R:R:Y191	4.79	No	Yes	0	8	8
266	R:R:M187	R:R:W236	3.49	No	Yes	0	8	9
267	R:R:E240	R:R:M187	5.41	No	No	0	9	8
268	R:R:L189	R:R:L193	4.15	No	No	0	3	6
269	R:R:N233	R:R:T190	7.31	Yes	No	2	9	9
270	R:R:T190	R:R:W236	4.85	No	Yes	2	9	9
271	R:R:T190	R:R:W267	6.06	No	No	2	9	9
272	R:R:N233	R:R:Y191	13.96	Yes	Yes	2	9	8
273	R:R:M237	R:R:Y191	4.79	Yes	Yes	2	9	8
274	R:R:Q383	R:R:Y191	7.89	No	Yes	2	9	8
275	R:R:G384	R:R:Y191	4.35	No	Yes	0	9	8
276	R:R:L193	R:R:M229	7.07	No	No	0	6	4
277	R:R:I198	R:R:N194	5.66	Yes	No	0	7	8
278	R:R:N194	R:R:N233	4.09	No	Yes	0	8	9
279	R:R:H226	R:R:I197	3.98	No	No	0	6	5
280	R:R:H226	R:R:I198	6.63	No	Yes	0	6	7
281	R:R:H201	R:R:V205	9.69	Yes	No	0	6	7
282	R:R:P207	R:R:V206	7.07	No	No	0	3	3
283	R:R:E210	R:R:N208	5.26	No	No	0	3	3
284	R:R:L211	R:R:N208	5.49	No	No	0	1	3
285	R:R:E210	R:R:R213	5.82	No	No	0	3	2
286	R:R:E210	R:R:R214	10.47	No	No	0	3	4
287	R:R:L211	R:R:P216	3.28	No	No	0	1	4
288	R:R:C289	R:R:V212	8.54	No	No	0	9	3
289	R:R:D215	R:R:K220	6.91	No	No	0	6	7
290	R:R:D215	R:R:N288	17.5	No	No	0	6	4
291	R:R:I221	R:R:V217	4.61	No	No	0	4	3
292	R:R:C219	R:R:C289	7.28	No	No	0	9	9
293	R:R:K220	R:R:N286	4.2	No	No	6	7	7
294	R:R:K220	R:R:W290	23.21	No	Yes	6	7	9
295	R:R:F225	R:R:I221	3.77	No	No	0	5	4
296	R:R:H223	R:R:Q227	14.84	No	No	0	5	7
297	R:R:H223	R:R:R281	5.64	No	Yes	0	5	7
298	R:R:F224	R:R:T274	6.49	No	No	0	5	6
299	R:R:H226	R:R:Q227	6.18	No	No	0	6	7
300	R:R:I301	R:R:Q227	4.12	No	No	0	7	7
301	R:R:C232	R:R:Y228	9.41	No	No	0	8	8
302	R:R:L271	R:R:Y228	9.38	No	No	0	4	8
303	R:R:M230	R:R:Y234	3.59	No	Yes	0	6	7
304	R:R:H302	R:R:M230	5.25	No	No	0	6	6
305	R:R:A231	R:R:P270	3.74	No	Yes	0	5	9
306	R:R:C232	R:R:W267	5.22	No	No	0	8	9
307	R:R:C232	R:R:P270	7.53	No	Yes	0	8	9
308	R:R:M237	R:R:N233	7.01	Yes	Yes	2	9	9
309	R:R:M237	R:R:Y234	3.59	Yes	Yes	2	9	7
310	R:R:V305	R:R:Y234	16.4	No	Yes	0	7	7
311	R:R:L309	R:R:Y234	3.52	No	Yes	2	7	7
312	R:R:F356	R:R:Y234	12.38	Yes	Yes	2	7	7
313	R:R:F235	R:R:F269	8.57	No	Yes	9	5	3
314	R:R:F235	R:R:P270	4.33	No	Yes	9	5	9
315	R:R:W236	R:R:Y263	3.86	Yes	No	2	9	5
316	R:R:G266	R:R:W236	7.04	No	Yes	0	9	9
317	R:R:W236	R:R:W267	18.74	Yes	No	2	9	9
318	R:R:M237	R:R:Q383	5.44	Yes	No	2	9	9
319	R:R:I242	R:R:L238	7.14	Yes	No	0	7	8
320	R:R:A308	R:R:L238	6.3	No	No	0	7	8
321	R:R:L238	R:R:N312	4.12	No	No	0	8	9
322	R:R:C239	R:R:L265	4.76	No	No	0	7	7
323	R:R:G241	R:R:N312	5.09	No	No	0	8	9
324	R:R:F315	R:R:I242	3.77	No	Yes	0	8	7
325	R:R:T246	R:R:Y243	3.75	No	Yes	0	7	8
326	R:R:Y243	R:R:Y262	3.97	Yes	No	0	8	7
327	R:R:I319	R:R:L244	4.28	No	No	0	9	9
328	R:R:L244	R:R:L348	4.15	No	No	0	9	9
329	R:R:H245	R:R:V249	6.92	No	Yes	0	8	6
330	R:R:F315	R:R:H245	28.28	No	No	0	8	8
331	R:R:H245	R:R:N318	5.1	No	No	0	8	8
332	R:R:A251	R:R:T254	5.03	No	No	0	6	6
333	R:R:Q257	R:R:Y262	5.64	No	No	0	5	7
334	R:R:R258	R:R:R260	10.66	No	No	0	5	3
335	R:R:L259	R:R:Y263	5.86	No	No	0	5	5
336	R:R:F269	R:R:P270	4.33	Yes	Yes	9	3	9
337	R:R:P273	R:R:V272	3.53	No	No	0	6	4
338	R:R:H277	R:R:R281	12.41	No	Yes	0	7	7
339	R:R:H277	R:R:L298	3.86	No	No	0	7	6
340	R:R:H277	R:R:I301	10.61	No	No	0	7	7
341	R:R:L297	R:R:T280	5.9	No	No	0	4	4
342	R:R:D287	R:R:R281	10.72	Yes	Yes	6	3	7
343	R:R:R281	R:R:W290	19.99	Yes	Yes	6	7	9
344	R:R:V283	R:R:Y284	5.05	No	No	0	3	2
345	R:R:D287	R:R:F285	9.55	Yes	No	0	3	6
346	R:R:F285	R:R:T295	11.67	No	No	0	6	4
347	R:R:N286	R:R:W290	4.52	No	Yes	6	7	9
348	R:R:D287	R:R:W290	3.35	Yes	Yes	6	3	9
349	R:R:D287	R:R:S292	4.42	Yes	No	0	3	4
350	R:R:C289	R:R:L291	7.94	No	No	0	9	6
351	R:R:E294	R:R:V293	5.7	No	No	0	3	6
352	R:R:L297	R:R:T295	4.42	No	No	0	4	4
353	R:R:G303	R:R:P304	4.06	No	Yes	0	4	9
354	R:R:F356	R:R:L309	3.65	Yes	No	2	7	7
355	R:R:F315	R:R:V311	5.24	No	No	0	8	6
356	R:R:L352	R:R:N312	5.49	No	No	0	9	9
357	R:R:F313	R:R:L317	8.53	No	No	0	6	5
358	R:R:F313	R:R:I354	5.02	No	No	0	6	6
359	R:R:L316	R:R:L348	4.15	No	No	0	9	9
360	R:R:I354	R:R:L316	5.71	No	No	0	6	9
361	R:R:N318	R:R:R321	4.82	No	No	0	8	8
362	R:R:M327	R:R:M337	4.33	No	No	0	7	7
363	R:R:K340	R:R:M327	5.76	No	No	0	8	7
364	R:R:E332	R:R:T330	4.23	No	No	0	5	5
365	R:R:A333	R:R:H336	4.39	No	No	0	5	6
366	R:R:E334	R:R:Y338	7.86	No	No	0	6	7
367	R:R:P350	R:R:V349	3.53	No	No	0	9	8
368	R:R:L351	R:R:L352	4.15	No	No	0	9	9
369	R:R:L351	R:R:Y391	17.58	No	No	0	9	8
370	R:R:I354	R:R:L352	5.71	No	No	0	6	9
371	R:R:F356	R:R:Q355	14.05	Yes	Yes	2	7	8
372	R:R:L379	R:R:Q355	13.31	No	Yes	0	5	8
373	R:R:I380	R:R:Q355	4.12	No	Yes	2	6	8
374	R:R:Q355	R:R:Q383	14.08	Yes	No	2	8	9
375	R:R:F356	R:R:M376	3.73	Yes	Yes	2	7	7
376	R:R:F356	R:R:I380	7.54	Yes	No	2	7	6
377	R:R:F359	R:R:V358	11.8	Yes	No	0	6	5
378	R:R:F359	R:R:Y372	5.16	Yes	Yes	2	6	7
379	R:R:F359	R:R:M376	3.73	Yes	Yes	2	6	7
380	R:R:G369	R:R:R362	6	No	Yes	0	4	4
381	R:R:R362	R:R:Y372	6.17	Yes	Yes	2	4	7
382	R:R:D373	R:R:R362	15.48	No	Yes	0	5	4
383	R:R:L368	R:R:P363	3.28	No	No	0	3	7
384	R:R:P363	R:R:Y372	11.13	No	Yes	0	7	7
385	R:R:L368	R:R:N365	10.98	No	No	0	3	4
386	R:R:K370	R:R:Y374	3.58	No	Yes	4	4	6
387	R:R:M376	R:R:Y372	8.38	Yes	Yes	2	7	7
388	R:R:I380	R:R:M376	5.83	No	Yes	2	6	7
389	R:R:H377	R:R:H381	9.55	Yes	Yes	0	7	9
390	R:R:F385	R:R:F386	5.36	No	No	0	5	5
391	R:R:F393	R:R:T389	3.89	No	No	0	8	5
392	R:R:I390	R:R:Y391	7.25	No	No	0	8	8
393	R:R:E397	R:R:N395	10.52	No	No	0	9	9
394	R:R:N395	R:R:V398	8.87	No	No	0	9	9
395	R:R:R404	R:R:T400	3.88	No	No	0	7	4
396	R:R:V402	R:R:W406	3.68	No	No	0	5	6
397	R:R:Q405	R:R:W406	4.38	No	No	0	4	6
398	R:R:C392	R:R:I169	3.27	No	No	0	9	8
399	E:E:N113	E:E:P114	3.26	Yes	No	0	9	5
400	R:R:C55	R:R:M59	3.24	No	No	0	9	5
401	L:L:A5	R:R:M376	3.22	No	Yes	0	0	7
402	R:R:D103	R:R:P104	3.22	No	No	0	3	3
403	R:R:F382	R:R:F386	3.22	No	No	0	7	5
404	E:E:P136	E:E:Q135	3.16	No	No	0	6	5
405	E:E:A116	E:E:L100	3.15	No	No	0	9	8
406	L:L:L16	R:R:A145	3.15	No	No	0	0	4
407	R:R:A388	R:R:L163	3.15	No	No	0	8	8
408	R:R:A344	R:R:L323	3.15	No	No	0	9	9
409	R:R:E294	R:R:P104	3.14	No	No	0	3	3
410	R:R:C219	R:R:D215	3.11	No	No	0	9	6
411	R:R:F39	R:R:Y41	3.09	No	No	0	4	3
412	E:E:I119	E:E:V65	3.07	No	No	0	5	5
413	R:R:I248	R:R:V249	3.07	No	Yes	0	7	6
414	R:R:I276	R:R:V272	3.07	No	No	0	5	4
415	E:E:M149	E:E:V145	3.04	No	No	0	9	7
416	R:R:M337	R:R:V324	3.04	No	No	0	7	5
417	R:R:F356	R:R:G353	3.01	Yes	No	0	7	9
418	E:E:R167	R:R:W261	3	No	Yes	0	8	2
419	L:L:L16	L:L:S20	3	No	No	0	0	0
420	R:R:K120	R:R:T127	3	No	No	0	1	4
421	R:R:L176	R:R:S175	3	No	No	0	9	8
422	E:E:L100	E:E:V65	2.98	No	No	0	8	5
423	E:E:V164	R:R:L265	2.98	No	No	0	9	7
424	R:R:L316	R:R:V320	2.98	No	No	0	9	7
425	R:R:L259	R:R:T182	2.95	No	No	0	5	5
426	E:E:I161	R:R:I242	2.94	No	Yes	10	9	7
427	R:R:I197	R:R:M229	2.92	No	No	0	5	4
428	E:E:S168	R:R:Q257	2.89	No	No	0	9	5
429	R:R:F235	R:R:P304	2.89	No	Yes	0	5	9
430	E:E:P92	E:E:R91	2.88	No	No	0	6	6
431	E:E:I151	E:E:L147	2.85	No	No	0	6	7
432	R:R:I198	R:R:L202	2.85	Yes	No	0	7	7
433	E:E:C68	E:E:F103	2.79	No	No	0	9	1
434	R:R:H201	R:R:V206	2.77	Yes	No	0	6	3
435	R:R:A278	R:R:F224	2.77	No	No	0	6	5
436	R:R:F314	R:R:V310	2.62	No	No	0	5	4
437	R:R:F313	R:R:V357	2.62	No	No	0	6	7
438	R:R:R328	R:R:V324	2.62	No	No	0	6	5
439	E:E:D144	E:E:E143	2.6	No	No	0	7	7
440	E:E:R91	E:E:T95	2.59	No	No	0	6	2
441	R:R:A278	R:R:W290	2.59	No	Yes	0	6	9
442	R:R:A282	R:R:W290	2.59	No	Yes	0	3	9
443	R:R:H201	R:R:L222	2.57	Yes	No	0	6	6
444	R:R:H201	R:R:L291	2.57	Yes	No	0	6	6
445	R:R:V147	R:R:Y374	2.52	No	Yes	0	4	6
446	R:R:V387	R:R:Y191	2.52	No	Yes	0	9	8
447	R:R:F173	R:R:I169	2.51	Yes	No	0	7	8
448	R:R:F137	R:R:M133	2.49	Yes	No	0	1	5
449	R:R:M48	R:R:R45	2.48	No	No	0	6	7
450	R:R:K256	R:R:R258	2.48	No	No	0	5	5
451	R:R:F382	R:R:L151	2.44	No	No	0	7	5
452	R:R:M337	R:R:Y338	2.39	No	No	0	7	7
453	R:R:L247	R:R:Y243	2.34	No	Yes	0	8	8
454	R:R:L264	R:R:W261	2.28	No	Yes	0	3	2
455	E:E:F67	E:E:H71	2.26	No	No	0	1	1
456	R:R:G268	R:R:P270	2.03	No	Yes	0	6	9
457	E:E:P153	R:R:P273	1.95	No	No	0	9	6
458	E:E:P153	R:R:P304	1.95	No	Yes	0	9	9
459	L:L:P28	L:L:P29	1.95	No	No	0	0	0
460	R:R:C219	R:R:P216	1.88	No	No	0	9	4
461	E:E:A152	E:E:P153	1.87	No	No	0	7	9
462	R:R:A87	R:R:P70	1.87	No	No	0	4	1
463	R:R:G44	R:R:V43	1.84	No	No	0	4	2
464	R:R:P216	R:R:S218	1.78	No	No	0	4	3
465	R:R:P350	R:R:V387	1.77	No	No	0	9	9
466	R:R:P86	R:R:T85	1.75	No	No	0	2	7
467	R:R:G44	R:R:K47	1.74	No	No	0	4	4
468	R:R:G168	R:R:L167	1.71	No	No	0	1	6
469	L:L:A13	R:R:V206	1.7	No	No	0	0	3
470	L:L:G24	L:L:N21	1.7	No	No	0	0	0
471	L:L:G24	L:L:N22	1.7	No	No	0	0	0
472	R:R:A341	R:R:V324	1.7	No	No	0	9	5
473	E:E:I89	E:E:P92	1.69	No	No	0	8	6
474	L:L:L27	L:L:P28	1.64	No	No	0	0	0
475	R:R:L62	R:R:P63	1.64	No	No	0	3	1
476	R:R:D101	R:R:P100	1.61	Yes	No	0	4	4
477	L:L:S19	R:R:T138	1.6	No	No	0	0	2
478	R:R:V249	R:R:V250	1.6	Yes	No	0	6	5
479	R:R:V249	R:R:V322	1.6	Yes	No	0	6	8
480	R:R:V310	R:R:V357	1.6	No	No	0	4	7
481	R:R:V398	R:R:V402	1.6	No	No	0	9	5
482	R:R:T345	R:R:V320	1.59	No	No	0	9	7
483	R:R:T345	R:R:V349	1.59	No	No	0	9	8
484	E:E:E143	E:E:P142	1.57	No	No	0	7	9
485	R:R:E140	R:R:P139	1.57	No	No	0	2	3
486	R:R:T274	R:R:T275	1.57	No	No	0	6	3
487	E:E:I161	E:E:V165	1.54	No	No	10	9	9
488	E:E:V165	R:R:I242	1.54	No	Yes	10	9	7
489	R:R:I153	R:R:V203	1.54	No	No	0	7	3
490	R:R:I165	R:R:V164	1.54	No	No	0	5	4
491	R:R:I199	R:R:V203	1.54	No	No	0	7	3
492	E:E:S90	R:R:K46	1.53	No	No	0	7	4
493	R:R:K46	R:R:V42	1.52	No	No	0	4	1
494	R:R:K120	R:R:V117	1.52	No	No	0	1	5
495	R:R:K185	R:R:V171	1.52	No	No	0	6	4
496	R:R:I279	R:R:T275	1.52	No	No	0	3	3
497	R:R:K326	R:R:V322	1.52	No	No	0	9	8
498	R:R:M346	R:R:V342	1.52	No	No	0	8	8
499	E:E:G110	R:R:R126	1.5	No	No	0	5	4
500	R:R:L151	R:R:S378	1.5	No	No	0	5	5
501	R:R:D113	R:R:V117	1.46	No	No	0	5	5
502	R:R:I200	R:R:M196	1.46	No	No	0	6	4
503	R:R:I371	R:R:M367	1.46	No	No	0	5	4
504	R:R:N396	R:R:T400	1.46	No	No	0	6	4
505	E:E:F159	E:E:P158	1.44	No	No	0	8	9
506	R:R:F359	R:R:P360	1.44	Yes	No	0	6	5
507	R:R:I200	R:R:L222	1.43	No	No	0	6	6
508	R:R:I347	R:R:L348	1.43	No	No	0	8	9
509	R:R:L323	R:R:M327	1.41	No	No	0	9	7
510	E:E:C155	E:E:F159	1.4	No	No	0	7	8
511	R:R:K120	R:R:N125	1.4	No	No	0	1	7
512	R:R:M367	R:R:N365	1.4	No	No	0	4	4
513	E:E:I126	E:E:Q125	1.37	No	No	0	5	5
514	L:L:T9	R:R:H381	1.37	No	Yes	0	0	9
515	E:E:D74	E:E:N70	1.35	No	No	0	1	2
516	R:R:D84	R:R:N73	1.35	No	No	0	4	4
517	R:R:E140	R:R:K143	1.35	No	No	0	2	1
518	R:R:E255	R:R:K256	1.35	No	No	0	6	5
519	R:R:A51	R:R:Y98	1.33	No	Yes	0	8	4
520	R:R:N396	R:R:Q399	1.32	No	No	0	6	7
521	R:R:E397	R:R:N396	1.31	No	No	0	9	6
522	E:E:E101	E:E:E105	1.27	No	No	0	8	5
523	E:E:H71	E:E:Q75	1.24	No	No	0	1	3
524	R:R:E332	R:R:H336	1.23	No	No	0	5	6
525	R:R:F39	R:R:L40	1.22	No	No	0	4	5
526	E:E:E122	E:E:F121	1.17	No	No	0	4	6
527	R:R:L148	R:R:Y374	1.17	No	Yes	4	5	6
528	E:E:E117	E:E:R118	1.16	No	No	0	8	4
529	R:R:F224	R:R:F225	1.07	No	No	0	5	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	E:E:Y61	6.5475	4	5	8
2	E:E:W69	6.5325	4	3	6
3	E:E:Y72	8.8	5	3	9
4	E:E:R97	8.335	4	0	7
5	E:E:F111	5.0125	4	0	8
6	E:E:N113	5.882	5	5	9
7	E:E:H127	7.95	6	3	8
8	E:E:F128	6.4925	4	0	9
9	E:E:P141	7.2725	4	0	9
10	L:L:T6	6.3725	4	2	0
11	L:L:T36	4.5975	4	1	0
12	L:L:?38	6.2	5	1	0
13	R:R:Y56	9.8375	4	0	3
14	R:R:R74	9.6775	4	0	4
15	R:R:W76	9.532	5	12	8
16	R:R:W79	13.9775	4	1	6
17	R:R:L80	7.915	4	1	5
18	R:R:W82	9.62167	6	1	9
19	R:R:Y98	7.39833	6	1	4
20	R:R:F99	9.274	5	1	5
21	R:R:D101	5.394	5	1	4
22	R:R:F102	7.5	6	1	4
23	R:R:W118	7.61667	6	1	9
24	R:R:H121	7.8675	4	11	4
25	R:R:N124	6.3575	4	11	5
26	R:R:W128	8.0825	4	0	5
27	R:R:S129	5.466	5	1	7
28	R:R:Y131	8.77429	7	1	5
29	R:R:F137	7.245	4	14	1
30	R:R:Y149	6.35	4	0	5
31	R:R:H156	7.2825	4	0	7
32	R:R:F173	6.056	5	0	7
33	R:R:H184	8.085	4	0	9
34	R:R:Y191	6.38333	6	2	8
35	R:R:I198	6.4375	4	0	7
36	R:R:H201	4.51	5	0	6
37	R:R:N233	8.0925	4	2	9
38	R:R:Y234	8.03667	6	2	7
39	R:R:W236	8.59	6	2	9
40	R:R:M237	5.2075	4	2	9
41	R:R:I242	3.8475	4	10	7
42	R:R:Y243	4.302	5	0	8
43	R:R:V249	3.2975	4	0	6
44	R:R:W261	5.1425	4	0	2
45	R:R:F269	5.6975	4	9	3
46	R:R:P270	4.392	5	9	9
47	R:R:R281	12.19	4	6	7
48	R:R:D287	7.01	4	6	3
49	R:R:W290	9.375	6	6	9
50	R:R:P304	3.495	4	0	9
51	R:R:Q355	11.39	4	2	8
52	R:R:F356	7.07857	7	2	7
53	R:R:F359	5.5325	4	2	6
54	R:R:R362	7.106	5	2	4
55	R:R:Y372	7.71	4	2	7
56	R:R:Y374	3.27	4	4	6
57	R:R:M376	4.978	5	2	7
58	R:R:H377	8.6275	4	4	7
59	R:R:H381	5.755	4	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	E:E:F111	E:E:R97	26.5004	4.28	Yes	Yes	0	8	7
2	E:E:R97	R:R:M49	29.4315	8.69	Yes	No	0	7	4
3	E:E:Y93	R:R:M49	28.6791	3.59	No	No	0	9	4
4	E:E:H124	E:E:Y93	55.8089	8.71	No	No	0	9	9
5	E:E:F128	E:E:H124	54.6453	6.79	Yes	No	0	9	9
6	E:E:F128	E:E:I89	15.7275	7.54	Yes	No	0	9	8
7	E:E:I89	E:E:P92	14.1588	1.69	No	No	0	8	6
8	E:E:R97	R:R:Q52	47.2384	11.68	Yes	No	0	7	6
9	E:E:Y93	R:R:Q52	28.6855	7.89	No	No	0	9	6
10	E:E:F128	E:E:H127	29.804	3.39	Yes	Yes	0	9	8
11	E:E:R97	R:R:M48	52.4547	8.69	Yes	No	0	7	6
12	E:E:F111	E:E:P112	30.4026	5.78	Yes	No	0	8	9
13	E:E:P112	R:R:R126	30.5877	4.32	No	No	0	9	4
14	R:R:Q52	R:R:W76	17.8418	14.24	No	Yes	0	6	8
15	R:R:C55	R:R:W76	12.7252	10.45	No	Yes	12	9	8
16	R:R:C55	R:R:M59	11.9434	3.24	No	No	0	9	5
17	R:R:M59	R:R:R74	11.1533	12.41	No	Yes	0	5	4
18	R:R:N124	R:R:R126	31.1678	7.23	Yes	No	0	5	4
19	R:R:H121	R:R:N124	31.5321	3.83	Yes	Yes	11	4	5
20	R:R:H121	R:R:W128	32.2386	11.64	Yes	Yes	0	4	5
21	R:R:N130	R:R:W128	99.0391	9.04	No	Yes	0	8	5
22	R:R:N130	R:R:T109	99.1438	4.39	No	No	0	8	5
23	R:R:T109	R:R:Y92	98.6256	6.24	No	No	13	5	4
24	R:R:K107	R:R:Y92	99.3895	8.36	No	No	0	3	4
25	R:R:F94	R:R:K107	99.4359	3.72	No	No	0	3	3
26	L:L:K1	R:R:F94	99.4791	7.44	No	No	0	0	3
27	L:L:K1	R:R:E294	99.5333	8.1	No	No	0	0	3
28	R:R:E294	R:R:V293	99.8966	5.7	No	No	0	3	6
29	L:L:C2	R:R:V293	100	3.42	No	No	0	0	6
30	L:L:C2	R:R:L298	50.6973	4.76	No	No	0	0	6
31	R:R:H277	R:R:L298	50.5985	3.86	No	No	0	7	6
32	R:R:H277	R:R:R281	12.5929	12.41	No	Yes	0	7	7
33	R:R:H277	R:R:I301	37.968	10.61	No	No	0	7	7
34	R:R:I301	R:R:Q227	37.8288	4.12	No	No	0	7	7
35	R:R:H226	R:R:Q227	43.3708	6.18	No	No	0	6	7
36	R:R:H226	R:R:I198	42.7047	6.63	No	Yes	0	6	7
37	R:R:I198	R:R:N194	30.4338	5.66	Yes	No	0	7	8
38	R:R:N194	R:R:N233	30.2354	4.09	No	Yes	0	8	9
39	L:L:C2	L:L:C7	50.8865	7.28	No	No	0	0	0
40	L:L:C7	L:L:R11	50.7749	4.18	No	No	0	0	0
41	L:L:R11	R:R:R362	50.1323	4.26	No	Yes	2	0	4
42	R:R:R362	R:R:Y372	50.3633	6.17	Yes	Yes	2	4	7
43	R:R:M376	R:R:Y372	49.3794	8.38	Yes	Yes	2	7	7
44	R:R:F356	R:R:M376	33.923	3.73	Yes	Yes	2	7	7
45	R:R:F356	R:R:Y234	17.0449	12.38	Yes	Yes	2	7	7
46	R:R:M237	R:R:Y234	17.523	3.59	Yes	Yes	2	9	7
47	R:R:M237	R:R:Y191	15.529	4.79	Yes	Yes	2	9	8
48	R:R:M187	R:R:Y191	48.362	4.79	No	Yes	0	8	8
49	R:R:E240	R:R:M187	47.6298	5.41	No	No	0	9	8
50	R:R:E240	R:R:L183	14.2833	5.3	No	No	0	9	8
51	R:R:L183	R:R:Y243	13.3618	4.69	No	Yes	0	8	8
52	R:R:Y243	R:R:Y262	10.4285	3.97	Yes	No	0	8	7
53	R:R:F356	R:R:Q355	15.761	14.05	Yes	Yes	2	7	8
54	R:R:Q355	R:R:Q383	31.1472	14.08	Yes	No	2	8	9
55	R:R:Q383	R:R:Y191	30.6506	7.89	No	Yes	2	9	8
56	R:R:I380	R:R:M376	15.9034	5.83	No	Yes	2	6	7
57	R:R:I380	R:R:Q355	15.8184	4.12	No	Yes	2	6	8
58	R:R:N233	R:R:Y191	19.5317	13.96	Yes	Yes	2	9	8
59	R:R:E240	R:R:H184	33.3098	11.08	No	Yes	0	9	9
60	R:R:H184	R:R:Y391	26.9658	5.44	Yes	No	0	9	8
61	R:R:L351	R:R:Y391	25.1468	17.58	No	No	0	9	8
62	R:R:L351	R:R:L352	24.2368	4.15	No	No	0	9	9
63	R:R:L352	R:R:N312	17.7426	5.49	No	No	0	9	9
64	R:R:L238	R:R:N312	15.8905	4.12	No	No	0	8	9
65	R:R:I242	R:R:L238	14.0348	7.14	Yes	No	0	7	8
66	R:R:H156	R:R:I198	16.6025	10.61	Yes	Yes	0	7	7
67	R:R:R281	R:R:W290	10.3853	19.99	Yes	Yes	6	7	9
68	R:R:M48	R:R:Y98	54.2765	13.17	No	Yes	0	6	4
69	R:R:W79	R:R:Y98	54.4712	4.82	Yes	Yes	1	6	4
70	L:L:P37	R:R:W79	28.9814	25.67	No	Yes	1	0	6
71	R:R:W79	R:R:Y131	29.9446	16.4	Yes	Yes	1	6	5
72	L:L:?38	L:L:P37	28.9726	12.19	Yes	No	1	0	0
73	L:L:?38	R:R:Y131	32.9156	5.8	Yes	Yes	1	0	5
74	L:L:?38	R:R:W128	67.1583	5.64	Yes	Yes	0	0	5
75	R:R:H156	R:R:S195	12.5856	9.76	Yes	No	0	7	7
76	R:R:I160	R:R:S195	12.2888	6.19	No	No	0	5	7
77	R:R:I160	R:R:I192	11.9912	4.42	No	No	0	5	7
78	R:R:I192	R:R:L163	11.6926	4.28	No	No	0	7	8
79	R:R:A388	R:R:L163	10.4891	3.15	No	No	0	8	8
80	R:R:V387	R:R:Y191	14.665	2.52	No	Yes	0	9	8
81	R:R:P350	R:R:V387	13.7399	1.77	No	No	0	9	9
82	R:R:P350	R:R:V349	12.8184	3.53	No	No	0	9	8
83	R:R:T345	R:R:V349	11.8975	1.59	No	No	0	9	8
84	R:R:T345	R:R:V320	10.9797	1.59	No	No	0	9	7
85	R:R:L316	R:R:V320	10.0739	2.98	No	No	0	9	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
E:E:G110	L:L:N35	5.09	0	No	No	5	0	1	0
E:E:D140	R:R:H296	6.3	0	No	No	9	2	2	1
L:L:?0	R:R:H296	3.46	8	No	No	0	2	0	1
L:L:?0	R:R:Y299	9.45	8	No	No	0	7	0	1
L:L:K1	R:R:F94	7.44	0	No	No	0	3	0	1
L:L:K1	R:R:E294	8.1	0	No	No	0	3	0	1
L:L:C2	R:R:V293	3.42	0	No	No	0	6	0	1
L:L:C2	R:R:L298	4.76	0	No	No	0	6	0	1
L:L:N3	R:R:W361	19.21	2	No	No	0	4	0	1
L:L:N3	R:R:R362	3.62	2	No	Yes	0	4	0	1
L:L:T4	R:R:M306	4.52	0	No	No	0	4	0	1
L:L:T6	R:R:Y234	8.74	2	Yes	Yes	0	7	0	1
L:L:T6	R:R:H302	6.85	2	Yes	No	0	6	0	1
L:L:T6	R:R:F356	5.19	2	Yes	Yes	0	7	0	1
L:L:A8	R:R:H377	4.39	0	No	Yes	0	7	0	1
L:L:Q10	R:R:H201	4.95	0	No	Yes	0	6	0	1
L:L:R11	R:R:R362	4.26	2	No	Yes	0	4	0	1
L:L:L12	R:R:L148	5.54	4	No	No	0	5	0	1
L:L:L12	R:R:H377	6.43	4	No	Yes	0	7	0	1
L:L:E14	R:R:V293	5.7	0	No	No	0	6	0	1
L:L:F15	R:R:K141	13.65	0	No	No	0	3	0	1
L:L:F15	R:R:L142	3.65	0	No	No	0	2	0	1
L:L:L16	R:R:Y149	3.52	0	No	Yes	0	5	0	1
L:L:H18	R:R:D97	7.56	0	No	No	0	2	0	1
L:L:S20	R:R:Y146	5.09	0	No	No	0	2	0	1
L:L:F23	R:R:Y146	7.22	0	No	No	0	2	0	1
L:L:T30	R:R:F99	16.86	1	No	Yes	0	5	0	1
L:L:T30	R:R:D101	10.12	1	No	Yes	0	4	0	1
L:L:T30	R:R:F102	3.89	1	No	Yes	0	4	0	1
L:L:V32	R:R:Y131	5.05	0	No	Yes	0	5	0	1
L:L:V32	R:R:N135	4.43	0	No	No	0	3	0	1
L:L:S34	R:R:H121	8.37	11	No	Yes	0	4	0	1
L:L:S34	R:R:N124	10.43	11	No	Yes	0	5	0	1
L:L:P37	R:R:W79	25.67	1	No	Yes	0	6	0	1
L:L:?38	R:R:W128	5.64	1	Yes	Yes	0	5	0	1
L:L:?38	R:R:S129	3.72	1	Yes	Yes	0	7	0	1
L:L:?38	R:R:Y131	5.8	1	Yes	Yes	0	5	0	1
L:L:?101	R:R:H296	6.15	8	No	No	0	2	0	1
R:R:D77	R:R:W82	11.17	1	No	Yes	9	9	2	2
R:R:D77	R:R:S129	5.89	1	No	Yes	9	7	2	1
R:R:D77	R:R:Y131	6.9	1	No	Yes	9	5	2	1
R:R:W79	R:R:Y98	4.82	1	Yes	Yes	6	4	1	2
R:R:F99	R:R:W79	9.02	1	Yes	Yes	5	6	1	1
R:R:W79	R:R:Y131	16.4	1	Yes	Yes	6	5	1	1
R:R:L80	R:R:W82	3.42	1	Yes	Yes	5	9	2	2
R:R:L80	R:R:P96	6.57	1	Yes	No	5	9	2	2
R:R:L80	R:R:Y131	7.03	1	Yes	Yes	5	5	2	1
R:R:K110	R:R:W82	29.01	1	No	Yes	8	9	2	2
R:R:S129	R:R:W82	3.71	1	Yes	Yes	7	9	1	2
R:R:F94	R:R:K107	3.72	0	No	No	3	3	1	2
R:R:P96	R:R:Y98	15.3	0	No	Yes	9	4	2	2
R:R:F102	R:R:P96	5.78	1	Yes	No	4	9	1	2
R:R:F99	R:R:Y98	6.19	1	Yes	Yes	5	4	1	2
R:R:D101	R:R:F99	3.58	1	Yes	Yes	4	5	1	1
R:R:F102	R:R:F99	10.72	1	Yes	Yes	4	5	1	1
R:R:D101	R:R:F102	3.58	1	Yes	Yes	4	4	1	1
R:R:D101	R:R:N135	8.08	1	Yes	No	4	3	1	1
R:R:C134	R:R:F102	12.57	0	No	Yes	9	4	2	1
R:R:F102	R:R:N135	8.46	1	Yes	No	4	3	1	1
R:R:V108	R:R:Y131	13.88	0	No	Yes	7	5	2	1
R:R:K110	R:R:S129	7.65	1	No	Yes	8	7	2	1
R:R:F119	R:R:W128	6.01	0	No	Yes	4	5	2	1
R:R:H121	R:R:P122	7.63	11	Yes	No	4	5	1	2
R:R:H121	R:R:N124	3.83	11	Yes	Yes	4	5	1	1
R:R:H121	R:R:W128	11.64	11	Yes	Yes	4	5	1	1
R:R:E123	R:R:N124	3.94	0	No	Yes	4	5	2	1
R:R:N124	R:R:R126	7.23	11	Yes	No	5	4	1	2
R:R:N130	R:R:W128	9.04	0	No	Yes	8	5	2	1
R:R:S129	R:R:Y131	6.36	1	Yes	Yes	7	5	1	1
R:R:P139	R:R:T138	3.5	0	No	No	3	2	2	1
R:R:L142	R:R:Y146	7.03	0	No	No	2	2	1	1
R:R:H377	R:R:L148	14.14	4	Yes	No	7	5	1	1
R:R:Y149	R:R:Y150	3.97	0	Yes	No	5	4	1	2
R:R:I153	R:R:Y149	10.88	0	No	Yes	7	5	2	1
R:R:L202	R:R:Y149	7.03	0	No	Yes	7	5	2	1
R:R:A152	R:R:H381	7.32	0	No	Yes	7	9	2	1
R:R:H156	R:R:H381	4.78	0	Yes	Yes	7	9	2	1
R:R:H201	R:R:V205	9.69	0	Yes	No	6	7	1	2
R:R:P207	R:R:V206	7.07	0	No	No	3	3	2	1
R:R:M230	R:R:Y234	3.59	0	No	Yes	6	7	2	1
R:R:H302	R:R:M230	5.25	0	No	No	6	6	1	2
R:R:M237	R:R:Y234	3.59	2	Yes	Yes	9	7	2	1
R:R:V305	R:R:Y234	16.4	0	No	Yes	7	7	2	1
R:R:L309	R:R:Y234	3.52	2	No	Yes	7	7	2	1
R:R:F356	R:R:Y234	12.38	2	Yes	Yes	7	7	1	1
R:R:H277	R:R:L298	3.86	0	No	No	7	6	2	1
R:R:E294	R:R:V293	5.7	0	No	No	3	6	1	1
R:R:F356	R:R:L309	3.65	2	Yes	No	7	7	1	2
R:R:F356	R:R:Q355	14.05	2	Yes	Yes	7	8	1	2
R:R:I380	R:R:Q355	4.12	2	No	Yes	6	8	2	2
R:R:F356	R:R:M376	3.73	2	Yes	Yes	7	7	1	1
R:R:F356	R:R:I380	7.54	2	Yes	No	7	6	1	2
R:R:F359	R:R:Y372	5.16	2	Yes	Yes	6	7	2	2
R:R:F359	R:R:M376	3.73	2	Yes	Yes	6	7	2	1
R:R:G369	R:R:R362	6	0	No	Yes	4	4	2	1
R:R:R362	R:R:Y372	6.17	2	Yes	Yes	4	7	1	2
R:R:D373	R:R:R362	15.48	0	No	Yes	5	4	2	1
R:R:M376	R:R:Y372	8.38	2	Yes	Yes	7	7	1	2
R:R:I380	R:R:M376	5.83	2	No	Yes	6	7	2	1
R:R:H377	R:R:H381	9.55	4	Yes	Yes	7	9	1	1
L:L:A5	R:R:M376	3.22	0	No	Yes	0	7	0	1
L:L:L16	R:R:A145	3.15	0	No	No	0	4	0	1
R:R:E294	R:R:P104	3.14	0	No	No	3	3	1	2
R:R:F356	R:R:G353	3.01	2	Yes	No	7	9	1	2
R:R:H201	R:R:V206	2.77	0	Yes	No	6	3	1	1
R:R:H201	R:R:L222	2.57	0	Yes	No	6	6	1	2
R:R:H201	R:R:L291	2.57	0	Yes	No	6	6	1	2
L:L:A13	R:R:V206	1.7	0	No	No	0	3	0	1
R:R:D101	R:R:P100	1.61	1	Yes	No	4	4	1	2
L:L:S19	R:R:T138	1.6	0	No	No	0	2	0	1
E:E:G110	R:R:R126	1.5	0	No	No	5	4	1	2
L:L:T9	R:R:H381	1.37	0	No	Yes	0	9	0	1
R:R:L148	R:R:Y374	1.17	4	No	Yes	5	6	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9BQ3_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.28
Number of Linked Nodes	480
Number of Links	529
Number of Hubs	59
Number of Links mediated by Hubs	229
Number of Communities	14
Number of Nodes involved in Communities	90
Number of Links involved in Communities	122

Path Summary
Number Of Nodes in MetaPath	86
Number Of Links MetaPath	85
Number of Shortest Paths	290076
Length Of Smallest Path	3
Average Path Length	29.1064
Length of Longest Path	52
Minimum Path Strength	1.315
Average Path Strength	6.86667
Maximum Path Strength	21.6
Minimum Path Correlation	0.7
Average Path Correlation	0.961407
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	2.63158
Average % Of Corr. Nodes	44.9828
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	31.8498
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• molecular transducer activity • coreceptor activity • signaling receptor activity • calcitonin family binding • amide binding • binding • adrenomedullin binding • peptide hormone binding • hormone binding • calcitonin family receptor activity • peptide receptor activity • adrenomedullin receptor activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • transmembrane signaling receptor activity • developmental process • heart development • multicellular organism development • multicellular organismal process • anatomical structure development • animal organ development • circulatory system development • system development • system process • circulatory system process • regulation of blood pressure • biological regulation • regulation of biological quality • blood circulation
Gene Ontology	Biological Process	• developmental process • heart development • multicellular organism development • multicellular organismal process • anatomical structure development • animal organ development • circulatory system development • system development • system process • circulatory system process • regulation of blood pressure • biological regulation • regulation of biological quality • blood circulation • localization • import into cell • receptor internalization • transport • cellular process • receptor-mediated endocytosis • endocytosis • establishment of localization • vesicle-mediated transport • blood vessel morphogenesis • tube development • angiogenesis • vasculature development • anatomical structure morphogenesis • tube morphogenesis • anatomical structure formation involved in morphogenesis • blood vessel development • regulation of biosynthetic process • regulation of biological process • regulation of cellular process • positive regulation of biological process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • positive regulation of macromolecule biosynthetic process • regulation of gene expression • positive regulation of metabolic process • biosynthetic process • positive regulation of gene expression • positive regulation of biosynthetic process • regulation of macromolecule biosynthetic process • metabolic process • positive regulation of macromolecule metabolic process • macromolecule metabolic process • regulation of metabolic process • positive regulation of cellular process • regulation of developmental process • cellular developmental process • regulation of vasculogenesis • regulation of cell differentiation • vasculogenesis • positive regulation of developmental process • positive regulation of cell differentiation • cell differentiation • positive regulation of vasculogenesis • establishment of protein localization • nitrogen compound transport • protein transport • macromolecule localization • intracellular protein localization • smooth muscle cell differentiation • cell development • muscle cell differentiation • muscle structure development • vascular associated smooth muscle cell differentiation • muscle cell development • vascular associated smooth muscle cell development • protein localization to cell periphery • cellular localization • protein localization to plasma membrane • localization within membrane • protein localization to membrane • cellular response to stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to stimulus • response to hormone • response to endogenous stimulus • response to chemical • cellular response to hormone stimulus • sprouting angiogenesis • negative regulation of vascular permeability • regulation of vascular permeability • vascular process in circulatory system • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • bicellular tight junction assembly • tight junction organization • apical junction assembly • cellular component organization • cellular component biogenesis • cell junction organization • cellular component assembly • cell junction assembly • tight junction assembly • cellular component organization or biogenesis • cell-cell junction assembly • cell-cell junction organization • intracellular transport • establishment of localization in cell • intracellular protein transport • regulation of signaling • regulation of signal transduction • regulation of response to stimulus • regulation of cell communication • regulation of G protein-coupled receptor signaling pathway • adrenomedullin receptor signaling pathway • calcitonin family receptor signaling pathway • regulation of vasculature development • regulation of multicellular organismal process • regulation of anatomical structure morphogenesis • regulation of multicellular organismal development • positive regulation of angiogenesis • positive regulation of vasculature development • regulation of angiogenesis • positive regulation of multicellular organismal process • extracellular matrix organization • basement membrane assembly • extracellular matrix assembly • basement membrane organization • extracellular structure organization • external encapsulating structure organization • amylin receptor signaling pathway • amylin receptor 2 signaling pathway • monoatomic ion transport • monoatomic cation transport • calcium ion transport • metal ion transport • negative regulation of endothelial cell apoptotic process • negative regulation of programmed cell death • regulation of apoptotic process • negative regulation of biological process • regulation of programmed cell death • cell death • negative regulation of apoptotic process • negative regulation of cellular process • endothelial cell apoptotic process • apoptotic process • programmed cell death • regulation of endothelial cell apoptotic process • adherens junction organization • adherens junction assembly • cellular response to growth factor stimulus • cellular response to vascular endothelial growth factor stimulus • response to growth factor • cellular anatomical structure • clathrin-coated pit • membrane • endomembrane system • cell surface • cell periphery • plasma membrane • intracellular anatomical structure • cytoplasm • protein-containing complex • plasma membrane protein complex • membrane protein complex • receptor complex • G protein-coupled receptor dimeric complex
Gene Ontology	Cellular Component	• cellular anatomical structure • clathrin-coated pit • membrane • endomembrane system • cell surface • cell periphery • plasma membrane • intracellular anatomical structure • cytoplasm • protein-containing complex • plasma membrane protein complex • membrane protein complex • receptor complex • G protein-coupled receptor dimeric complex • adrenomedullin receptor complex • plasma membrane signaling receptor complex • G protein-coupled receptor complex • calcitonin family receptor complex • membrane-bounded organelle • intracellular organelle • organelle • lytic vacuole • vacuole • intracellular membrane-bounded organelle • lysosome • protein binding • binding • signaling receptor binding • amide binding • amyloid-beta binding • peptide binding • molecular function activator activity • molecular function regulator activity • signaling receptor regulator activity • receptor ligand activity • signaling receptor activator activity • hormone activity • lipid binding • identical protein binding • cellular response to stimulus • positive regulation of cell communication • regulation of cellular process • positive regulation of signal transduction • response to stimulus • signaling • positive regulation of biological process • regulation of signal transduction • intracellular signal transduction • cell communication • positive regulation of response to stimulus • regulation of intracellular signal transduction • intracellular signaling cassette • regulation of calcium-mediated signaling • positive regulation of calcium-mediated signaling • signal transduction • positive regulation of cellular process • regulation of biological process • regulation of signaling • biological regulation • positive regulation of intracellular signal transduction • regulation of response to stimulus • calcium-mediated signaling • regulation of cell communication • cellular process • positive regulation of signaling • apoptotic process • cell death • programmed cell death • positive regulation of programmed cell death • regulation of apoptotic process • regulation of programmed cell death • positive regulation of apoptotic process • behavior • multicellular organismal process • eating behavior • feeding behavior • cell-cell signaling • amylin receptor 1 signaling pathway • amylin receptor signaling pathway • calcitonin family receptor signaling pathway • G protein-coupled receptor signaling pathway • regulation of cellular component organization • negative regulation of cellular component organization • protein-containing complex organization • negative regulation of biological process • regulation of cellular component biogenesis • negative regulation of protein-containing complex assembly • cellular component organization • cellular component biogenesis • regulation of protein-containing complex assembly • cellular component assembly • protein-containing complex assembly • negative regulation of cellular process • cellular component organization or biogenesis • myeloid leukocyte differentiation • regulation of leukocyte differentiation • cellular developmental process • regulation of developmental process • cell development • regulation of cell differentiation • regulation of cell development • regulation of osteoclast differentiation • multicellular organism development • cell differentiation • osteoclast differentiation • anatomical structure development • regulation of immune system process • regulation of multicellular organismal process • negative regulation of cell differentiation • negative regulation of hemopoiesis • developmental process • regulation of multicellular organismal development • negative regulation of leukocyte differentiation • hemopoiesis • regulation of myeloid cell differentiation • negative regulation of developmental process • regulation of myeloid leukocyte differentiation • negative regulation of myeloid cell differentiation • negative regulation of osteoclast differentiation • negative regulation of myeloid leukocyte differentiation • negative regulation of cell development • myeloid cell differentiation • negative regulation of immune system process • immune system process • regulation of hemopoiesis • negative regulation of multicellular organismal process • leukocyte differentiation • positive regulation of MAPK cascade • regulation of MAPK cascade • MAPK cascade • negative regulation of tissue remodeling • homeostatic process • negative regulation of bone remodeling • regulation of bone remodeling • tissue homeostasis • regulation of tissue remodeling • regulation of bone resorption • bone resorption • negative regulation of bone resorption • multicellular organismal-level homeostasis • tissue remodeling • bone remodeling • anatomical structure homeostasis • amylin receptor 2 signaling pathway • system process • sensory perception • nervous system process • sensory perception of pain • positive regulation of cAMP/PKA signal transduction • cAMP/PKA signal transduction • regulation of cAMP/PKA signal transduction • negative regulation of amyloid fibril formation • regulation of amyloid fibril formation • amyloid fibril formation • regulation of primary metabolic process • negative regulation of supramolecular fiber organization • protein metabolic process • negative regulation of protein metabolic process • negative regulation of macromolecule metabolic process • regulation of protein metabolic process • negative regulation of metabolic process • primary metabolic process • regulation of macromolecule metabolic process • regulation of supramolecular fiber organization • metabolic process • macromolecule metabolic process • supramolecular fiber organization • regulation of metabolic process • amylin receptor 3 signaling pathway • extracellular region • somatodendritic compartment • cell body • neuronal cell body • extracellular space • calcitonin family receptor activity • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • calcitonin receptor activity • amylin receptor activity • calcitonin gene-related peptide receptor activity • calcitonin binding • calcitonin family binding • peptide hormone binding • hormone binding • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • catabolic process • RNA metabolic process • macromolecule catabolic process • nucleobase-containing compound metabolic process • post-transcriptional regulation of gene expression • regulation of RNA metabolic process • regulation of mRNA catabolic process • regulation of nucleobase-containing compound metabolic process • RNA catabolic process • regulation of biosynthetic process • mRNA catabolic process • regulation of catabolic process • gene expression • mRNA metabolic process • macromolecule biosynthetic process • nucleic acid metabolic process • nucleobase-containing compound catabolic process • regulation of mRNA stability • regulation of gene expression • negative regulation of gene expression • biosynthetic process • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • regulation of RNA stability • nucleic acid catabolic process • regulation of macromolecule biosynthetic process • regulation of mRNA metabolic process • positive regulation of ERK1 and ERK2 cascade • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of macromolecule biosynthetic process • positive regulation of metabolic process • positive regulation of gene expression • positive regulation of biosynthetic process • positive regulation of macromolecule metabolic process • regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • phosphatidylinositol 3-kinase/protein kinase B signal transduction • response to corticosteroid • response to lipid • response to hormone • response to steroid hormone • response to chemical • response to endogenous stimulus • response to glucocorticoid • adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • response to amyloid-beta • cell surface receptor signaling pathway • calcitonin gene-related peptide receptor signaling pathway • ossification • regulation of ossification • negative regulation of ossification • cell projection • cilium • plasma membrane bounded cell projection • amylin receptor complex • amylin receptor complex 3 • amylin receptor complex 2 • amylin receptor complex 1 • axon • neuron projection • acrosomal vesicle • intracellular vesicle • cytoplasmic vesicle • secretory granule • secretory vesicle • vesicle • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • sensory perception of chemical stimulus • sensory perception of smell • cellular response to nitrogen compound • response to peptide hormone • cellular response to peptide hormone stimulus • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • cellular response to hormone stimulus • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • adaptive thermogenesis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • localization • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • regulation of protein transport • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • inflammatory response to antigenic stimulus • regulation of response to stress • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • extrinsic component of plasma membrane • catalytic complex • cytoplasmic side of membrane • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular membrane-bounded organelle • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • trans-Golgi network • organelle membrane • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of taste • sensory organ development • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • cell population proliferation • small GTPase-mediated signal transduction • Ras protein signal transduction • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • vacuolar membrane • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation
SCOP2	Domain Identifier	• RAMP1-like • G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• RAMP1-like • G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	GGL
PDB Residues	L:L:?0
Environment Details	Open EMBL-EBI Page
Code	GGL
Name	Glutamic acid
Synonyms	Glutamic acid
Identifier
Formula	C5 H9 N O4
Molecular Weight	147.129
SMILES
PubChem	44272391
Formal Charge	0
Total Atoms	19
Total Chiral Atoms	1
Total Bonds	18
Total Aromatic Bonds	0


Code	NH2
PDB Residues	L:L:?38
Environment Details	Open EMBL-EBI Page
Code	NH2
Name	AMINO GROUP
Synonyms
Identifier
Formula	H2 N
Molecular Weight	16.023
SMILES
PubChem	123329
Formal Charge	0
Total Atoms	3
Total Chiral Atoms	0
Total Bonds	2
Total Aromatic Bonds	0


Code	A1B
PDB Residues	L:L:?101
Environment Details	Open EMBL-EBI Page
Code	A1B
Name	1-deoxy-alpha-L-xylulofuranose-1,2-borate
Synonyms
Identifier
Formula	C5 H10 B O6
Molecular Weight	176.94
SMILES
PubChem	118797262
Formal Charge	-1
Total Atoms	22
Total Chiral Atoms	3
Total Bonds	23
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	E
Protein	RAMP2
UniProt	O60895
Sequence	>9BQ3_nogp_Chain_E N Y E T A V Q F C W N H Y K D Q M D P I E K D W C D W A M I S R P Y S T L R D C L E H F A E L F D L G F P N P L A E R I I F E T H Q I H F A N C S L V Q P T F S D P P E D V L L A M I I A P I C L I P F L I T L V V W R S K D Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	R
Protein	Receptor
UniProt	P30988
Sequence	>9BQ3_nogp_Chain_R F L Y V V G R K K M M D A Q Y K C Y D R M Q Q L P A Y P Y C N R T W D G W L C W D D T P A G V L S Y Q F C P D Y F P D F D P S E K V T K Y C D V W F K H P E N N R T W S N Y T M C N A F T P E K L K N A Y V L Y Y L A I V G H S L S I F T L V I S L G I F V F F R S L G C Q R V T L H K N M F L T Y I L N S M I I I I H L V E V V P N G E L V R R D P V S C K I L H F F H Q Y M M A C N Y F W M L C E G I Y L H T L I V V A V F T E K Q R L R W Y Y L L G W G F P L V P T T I H A I T R A V Y F N D N C W L S V E T H L L Y I I H G P V M A A L V V N F F F L L N I V R V L V T K M R E T H E A E S H M Y L K A V K A T M I L V P L L G I Q F V V F P W R P S N K M L G K I Y D Y V M H S L I H F Q G F F V A T I Y C F C N N E V Q T T V K R Q W Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7TYH	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Calcitonin-1	-	Gs/β1/γ2; RAMP2	3.3	2022-03-23	doi.org/10.1126/science.abm9609
	7TYH (No Gprot)	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Calcitonin-1	-		3.3	2022-03-23	doi.org/10.1126/science.abm9609
	7TYY	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Calcitonin-1	-	Gs/β1/γ2; RAMP2	3	2022-03-23	doi.org/10.1126/science.abm9609
	7TYY (No Gprot)	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Calcitonin-1	-		3	2022-03-23	doi.org/10.1126/science.abm9609
	7TYX	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Amylin	-	Gs/β1/γ2; RAMP2	2.55	2022-03-30	doi.org/10.1126/science.abm9609
	7TYX (No Gprot)	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Amylin	-		2.55	2022-03-30	doi.org/10.1126/science.abm9609
	9BQ3	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Cagrilintide	-	Gs/β1/γ2; RAMP2	2.8	2025-04-23	To be published
	9BQ3 (No Gprot)	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Cagrilintide	-		2.8	2025-04-23	To be published

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