psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	E:E:F107	E:E:N60	3.62	No	No	0	5	3
2	E:E:A104	E:E:Y61	4	No	Yes	5	9	8
3	E:E:L109	E:E:Y61	7.03	No	Yes	5	7	8
4	E:E:N113	E:E:Y61	10.47	Yes	Yes	5	9	8
5	E:E:L115	E:E:Y61	4.69	No	Yes	5	4	8
6	E:E:E62	E:E:L115	3.98	No	No	0	3	4
7	E:E:A64	E:E:F103	9.71	No	No	0	3	1
8	E:E:N70	E:E:Q66	11.88	No	No	0	2	4
9	E:E:F67	E:E:N70	3.62	No	No	0	1	2
10	E:E:C68	E:E:C99	7.28	No	No	0	9	9
11	E:E:C68	E:E:L100	4.76	No	No	0	9	8
12	E:E:W69	E:E:Y72	7.72	Yes	Yes	3	6	9
13	E:E:K73	E:E:W69	8.12	No	Yes	0	5	6
14	E:E:T123	E:E:W69	6.06	No	Yes	3	8	6
15	E:E:H127	E:E:W69	4.23	Yes	Yes	3	8	6
16	E:E:M76	E:E:Y72	7.18	No	Yes	3	9	9
17	E:E:L96	E:E:Y72	17.58	No	Yes	0	8	9
18	E:E:T123	E:E:Y72	4.99	No	Yes	3	8	9
19	E:E:H127	E:E:Y72	6.53	Yes	Yes	3	8	9
20	E:E:P92	E:E:Q75	7.9	No	No	0	6	3
21	E:E:M76	E:E:W83	12.8	No	No	3	9	7
22	E:E:H127	E:E:M76	9.19	Yes	No	3	8	9
23	E:E:D77	E:E:P78	8.05	No	No	0	4	5
24	E:E:D82	E:E:I79	5.6	No	No	0	6	7
25	E:E:I79	E:E:W83	8.22	No	No	0	7	7
26	E:E:D82	E:E:D85	5.32	No	No	0	6	7
27	E:E:D82	E:E:M88	4.16	No	No	0	6	5
28	E:E:H127	E:E:W83	13.75	Yes	No	3	8	7
29	E:E:C131	E:E:C84	7.28	No	No	0	9	9
30	E:E:A87	E:E:D85	4.63	No	No	0	5	7
31	E:E:S90	E:E:W86	7.41	No	No	0	7	9
32	E:E:W86	R:R:Y53	6.75	No	No	0	9	1
33	E:E:F128	E:E:I89	7.54	Yes	No	0	9	8
34	E:E:H124	E:E:Y93	8.71	No	No	0	9	9
35	E:E:Y93	R:R:M49	3.59	No	No	0	9	4
36	E:E:Y93	R:R:Q52	7.89	No	No	0	9	6
37	E:E:D98	E:E:S94	4.42	No	No	0	1	8
38	E:E:F111	E:E:R97	4.28	Yes	Yes	0	8	7
39	E:E:R97	R:R:M48	8.69	Yes	No	0	7	6
40	E:E:R97	R:R:M49	8.69	Yes	No	0	7	4
41	E:E:R97	R:R:Q52	11.68	Yes	No	0	7	6
42	E:E:D98	R:R:R45	7.15	No	No	0	1	7
43	E:E:E101	E:E:F111	5.83	No	Yes	0	8	8
44	E:E:E105	E:E:H102	4.92	No	No	0	5	1
45	E:E:A104	E:E:L109	4.73	No	No	5	9	7
46	E:E:E105	E:E:L106	3.98	No	No	0	5	1
47	E:E:F107	E:E:L106	4.87	No	No	0	5	1
48	E:E:L109	E:E:N113	6.87	No	Yes	5	7	9
49	E:E:G110	L:L:N35	5.09	No	No	0	5	0
50	E:E:F111	E:E:P112	5.78	Yes	No	0	8	9
51	E:E:A116	E:E:F111	4.16	No	Yes	0	9	8
52	E:E:P112	R:R:R126	4.32	No	No	0	9	4
53	E:E:L115	E:E:N113	4.12	No	Yes	5	4	9
54	E:E:A116	E:E:N113	4.69	No	Yes	0	9	9
55	E:E:E117	R:R:Y56	6.73	No	Yes	0	8	3
56	E:E:I120	R:R:Y56	13.3	No	Yes	0	9	3
57	E:E:F121	E:E:Q125	10.54	No	No	7	6	5
58	E:E:F121	R:R:Q60	4.68	No	No	7	6	3
59	E:E:F128	E:E:H124	6.79	Yes	No	0	9	9
60	E:E:H124	R:R:Y56	8.71	No	Yes	0	9	3
61	E:E:Q125	R:R:Q60	11.52	No	No	7	5	3
62	E:E:H127	E:E:I126	10.61	Yes	No	0	8	5
63	E:E:F128	E:E:H127	3.39	Yes	Yes	0	9	8
64	E:E:F128	R:R:Y53	8.25	Yes	No	0	9	1
65	E:E:L133	R:R:K54	8.46	No	No	0	4	4
66	E:E:L133	R:R:D57	13.57	No	No	0	4	4
67	E:E:P136	R:R:K54	3.35	No	No	0	6	4
68	E:E:F138	E:E:T137	12.97	No	No	0	4	6
69	E:E:F138	R:R:F285	21.43	No	No	0	4	6
70	E:E:D140	E:E:P141	4.83	No	Yes	0	9	9
71	E:E:D140	R:R:H296	6.3	No	No	0	9	2
72	E:E:L146	E:E:P141	9.85	No	Yes	0	8	9
73	E:E:P141	R:R:Y284	11.13	Yes	No	0	9	2
74	E:E:P141	R:R:L297	3.28	Yes	No	0	9	4
75	E:E:P142	E:E:V145	5.3	No	No	0	9	7
76	E:E:I150	E:E:L146	4.28	No	No	0	9	8
77	E:E:M149	R:R:T280	6.02	No	No	0	9	4
78	E:E:M149	R:R:I300	4.37	No	No	0	9	8
79	E:E:I154	R:R:P304	5.08	No	Yes	0	9	9
80	E:E:L156	R:R:F269	4.87	No	Yes	0	9	3
81	E:E:I157	E:E:P158	3.39	No	No	0	9	9
82	E:E:I157	R:R:F269	5.02	No	Yes	0	9	3
83	E:E:L160	R:R:L265	4.15	No	No	0	9	7
84	E:E:T162	E:E:W166	4.85	No	No	0	8	8
85	E:E:L163	R:R:W261	9.11	No	Yes	0	9	2
86	E:E:V164	R:R:Y262	6.31	No	No	0	9	7
87	E:E:V165	E:E:W166	3.68	No	No	0	9	8
88	E:E:S168	R:R:W261	6.18	No	Yes	0	9	2
89	E:E:D170	E:E:K169	4.15	No	No	0	8	9
90	L:L:?0	L:L:?101	40.12	No	No	8	0	0
91	L:L:?0	R:R:H296	3.46	No	No	8	0	2
92	L:L:?0	R:R:Y299	9.45	No	No	0	0	7
93	L:L:K1	R:R:F94	7.44	No	No	0	0	3
94	L:L:K1	R:R:E294	8.1	No	No	0	0	3
95	L:L:C2	L:L:C7	7.28	No	No	0	0	0
96	L:L:C2	R:R:V293	3.42	No	No	0	0	6
97	L:L:C2	R:R:L298	4.76	No	No	0	0	6
98	L:L:N3	L:L:R11	3.62	No	No	2	0	0
99	L:L:N3	R:R:W361	19.21	No	No	0	0	4
100	L:L:N3	R:R:R362	3.62	No	Yes	2	0	4
101	L:L:T4	L:L:T6	4.71	No	Yes	0	0	0
102	L:L:T4	R:R:M306	4.52	No	No	0	0	4
103	L:L:T6	R:R:Y234	8.74	Yes	Yes	2	0	7
104	L:L:T6	R:R:H302	6.85	Yes	No	0	0	6
105	L:L:T6	R:R:F356	5.19	Yes	Yes	2	0	7
106	L:L:C7	L:L:R11	4.18	No	No	0	0	0
107	L:L:A8	R:R:H377	4.39	No	Yes	0	0	7
108	L:L:Q10	R:R:H201	4.95	No	Yes	0	0	6
109	L:L:R11	R:R:R362	4.26	No	Yes	2	0	4
110	L:L:L12	R:R:L148	5.54	No	No	4	0	5
111	L:L:L12	R:R:H377	6.43	No	Yes	4	0	7
112	L:L:E14	L:L:R17	10.47	No	No	0	0	0
113	L:L:E14	R:R:V293	5.7	No	No	0	0	6
114	L:L:F15	L:L:S19	7.93	No	No	0	0	0
115	L:L:F15	R:R:K141	13.65	No	No	0	0	3
116	L:L:F15	R:R:L142	3.65	No	No	0	0	2
117	L:L:L16	R:R:Y149	3.52	No	Yes	0	0	5
118	L:L:H18	L:L:S19	6.97	No	No	0	0	0
119	L:L:H18	R:R:D97	7.56	No	No	0	0	2
120	L:L:S20	R:R:Y146	5.09	No	No	0	0	2
121	L:L:L27	L:L:N21	8.24	No	No	0	0	0
122	L:L:F23	R:R:Y146	7.22	No	No	0	0	2
123	L:L:G24	L:L:P25	4.06	No	No	0	0	0
124	L:L:T30	R:R:F99	16.86	No	Yes	1	0	5
125	L:L:T30	R:R:D101	10.12	No	Yes	1	0	4
126	L:L:T30	R:R:F102	3.89	No	Yes	1	0	4
127	L:L:G33	L:L:N31	3.39	No	No	1	0	0
128	L:L:N31	L:L:T36	5.85	No	Yes	1	0	0
129	L:L:V32	R:R:Y131	5.05	No	Yes	0	0	5
130	L:L:V32	R:R:N135	4.43	No	No	0	0	3
131	L:L:G33	L:L:T36	3.64	No	Yes	1	0	0
132	L:L:S34	R:R:H121	8.37	No	Yes	11	0	4
133	L:L:S34	R:R:N124	10.43	No	Yes	11	0	5
134	L:L:P37	L:L:T36	5.25	No	Yes	1	0	0
135	L:L:?38	L:L:T36	3.65	Yes	Yes	1	0	0
136	L:L:?38	L:L:P37	12.19	Yes	No	1	0	0
137	L:L:P37	R:R:W79	25.67	No	Yes	1	0	6
138	L:L:?38	R:R:W128	5.64	Yes	Yes	0	0	5
139	L:L:?38	R:R:S129	3.72	Yes	Yes	1	0	7
140	L:L:?38	R:R:Y131	5.8	Yes	Yes	1	0	5
141	L:L:?101	R:R:H296	12.48	No	No	8	0	2
142	R:R:L40	R:R:P100	3.28	No	No	0	5	4
143	R:R:K47	R:R:Y98	3.58	No	Yes	0	4	4
144	R:R:M48	R:R:Y98	13.17	No	Yes	0	6	4
145	R:R:D50	R:R:K54	5.53	No	No	0	2	4
146	R:R:Q52	R:R:W76	14.24	No	Yes	0	6	8
147	R:R:C55	R:R:W76	10.45	No	Yes	12	9	8
148	R:R:C55	R:R:C81	7.28	No	No	12	9	9
149	R:R:W76	R:R:Y56	10.61	Yes	Yes	0	8	3
150	R:R:D57	R:R:Q61	3.92	No	No	0	4	3
151	R:R:Q61	R:R:R58	22.2	No	No	0	3	3
152	R:R:L62	R:R:R58	3.64	No	No	0	3	3
153	R:R:M59	R:R:R74	12.41	No	Yes	0	5	4
154	R:R:L62	R:R:R74	4.86	No	Yes	0	3	4
155	R:R:C112	R:R:C72	7.28	No	No	1	9	9
156	R:R:C72	R:R:W118	14.37	No	Yes	1	9	9
157	R:R:D83	R:R:R74	8.34	No	Yes	0	5	4
158	R:R:D84	R:R:R74	13.1	No	Yes	0	4	4
159	R:R:T75	R:R:W118	6.06	No	Yes	0	5	9
160	R:R:G78	R:R:W76	8.44	No	Yes	0	5	8
161	R:R:C81	R:R:W76	3.92	No	Yes	12	9	8
162	R:R:D77	R:R:W82	11.17	No	Yes	1	9	9
163	R:R:D77	R:R:S129	5.89	No	Yes	1	9	7
164	R:R:D77	R:R:Y131	6.9	No	Yes	1	9	5
165	R:R:W79	R:R:Y98	4.82	Yes	Yes	1	6	4
166	R:R:F99	R:R:W79	9.02	Yes	Yes	1	5	6
167	R:R:W79	R:R:Y131	16.4	Yes	Yes	1	6	5
168	R:R:L80	R:R:W82	3.42	Yes	Yes	1	5	9
169	R:R:L80	R:R:Q93	14.64	Yes	No	1	5	6
170	R:R:L80	R:R:P96	6.57	Yes	No	0	5	9
171	R:R:L80	R:R:Y131	7.03	Yes	Yes	1	5	5
172	R:R:S91	R:R:W82	4.94	No	Yes	0	5	9
173	R:R:Q93	R:R:W82	5.48	No	Yes	1	6	9
174	R:R:K110	R:R:W82	29.01	No	Yes	1	8	9
175	R:R:S129	R:R:W82	3.71	Yes	Yes	1	7	9
176	R:R:C112	R:R:T85	3.38	No	No	1	9	7
177	R:R:T85	R:R:W118	6.06	No	Yes	1	7	9
178	R:R:P86	R:R:V89	8.84	No	No	0	2	5
179	R:R:G88	R:R:Y111	4.35	No	No	0	8	4
180	R:R:L90	R:R:Y92	5.86	No	No	13	4	4
181	R:R:L90	R:R:T109	5.9	No	No	13	4	5
182	R:R:L90	R:R:Y111	7.03	No	No	0	4	4
183	R:R:K107	R:R:Y92	8.36	No	No	0	3	4
184	R:R:T109	R:R:Y92	6.24	No	No	13	5	4
185	R:R:F94	R:R:K107	3.72	No	No	0	3	3
186	R:R:C95	R:R:V108	3.42	No	No	0	9	7
187	R:R:C134	R:R:C95	7.28	No	No	0	9	9
188	R:R:P96	R:R:Y98	15.3	No	Yes	0	9	4
189	R:R:F102	R:R:P96	5.78	Yes	No	0	4	9
190	R:R:F99	R:R:Y98	6.19	Yes	Yes	1	5	4
191	R:R:D101	R:R:F99	3.58	Yes	Yes	1	4	5
192	R:R:F102	R:R:F99	10.72	Yes	Yes	1	4	5
193	R:R:D101	R:R:F102	3.58	Yes	Yes	1	4	4
194	R:R:D101	R:R:N135	8.08	Yes	No	1	4	3
195	R:R:C134	R:R:F102	12.57	No	Yes	0	9	4
196	R:R:F102	R:R:N135	8.46	Yes	No	1	4	3
197	R:R:D103	R:R:S105	10.31	No	No	0	3	1
198	R:R:D103	R:R:E106	5.2	No	No	0	3	4
199	R:R:E106	R:R:F137	7	No	Yes	14	4	1
200	R:R:E106	R:R:K366	5.4	No	No	14	4	3
201	R:R:V108	R:R:Y131	13.88	No	Yes	0	7	5
202	R:R:N130	R:R:T109	4.39	No	No	0	8	5
203	R:R:K110	R:R:W118	10.44	No	Yes	1	8	9
204	R:R:K110	R:R:S129	7.65	No	Yes	1	8	7
205	R:R:C112	R:R:W118	3.92	No	Yes	1	9	9
206	R:R:T127	R:R:W118	4.85	No	Yes	0	4	9
207	R:R:F119	R:R:W128	6.01	No	Yes	0	4	5
208	R:R:H121	R:R:P122	7.63	Yes	No	0	4	5
209	R:R:H121	R:R:N124	3.83	Yes	Yes	11	4	5
210	R:R:H121	R:R:W128	11.64	Yes	Yes	0	4	5
211	R:R:E123	R:R:N124	3.94	No	Yes	0	4	5
212	R:R:N124	R:R:R126	7.23	Yes	No	0	5	4
213	R:R:N130	R:R:W128	9.04	No	Yes	0	8	5
214	R:R:S129	R:R:Y131	6.36	Yes	Yes	1	7	5
215	R:R:N130	R:R:T132	4.39	No	No	0	8	6
216	R:R:A136	R:R:F137	8.32	No	Yes	0	2	1
217	R:R:F137	R:R:K366	11.17	Yes	No	14	1	3
218	R:R:P139	R:R:T138	3.5	No	No	0	3	2
219	R:R:L142	R:R:Y146	7.03	No	No	0	2	2
220	R:R:K370	R:R:N144	4.2	No	No	4	4	4
221	R:R:N144	R:R:Y374	5.81	No	Yes	4	4	6
222	R:R:H377	R:R:L148	14.14	Yes	No	4	7	5
223	R:R:Y149	R:R:Y150	3.97	Yes	No	0	5	4
224	R:R:I153	R:R:Y149	10.88	No	Yes	0	7	5
225	R:R:L202	R:R:Y149	7.03	No	Yes	0	7	5
226	R:R:A152	R:R:H381	7.32	No	Yes	0	7	9
227	R:R:G155	R:R:V154	3.68	No	No	0	8	6
228	R:R:F382	R:R:G155	6.02	No	No	0	7	8
229	R:R:H156	R:R:S195	9.76	Yes	No	0	7	7
230	R:R:H156	R:R:I198	10.61	Yes	Yes	0	7	7
231	R:R:H156	R:R:I199	3.98	Yes	No	0	7	7
232	R:R:H156	R:R:H381	4.78	Yes	Yes	0	7	9
233	R:R:F385	R:R:L158	6.09	No	No	0	5	4
234	R:R:G384	R:R:S159	3.71	No	No	0	9	9
235	R:R:I160	R:R:I192	4.42	No	No	0	5	7
236	R:R:I160	R:R:S195	6.19	No	No	0	5	7
237	R:R:F161	R:R:I165	5.02	No	No	0	4	5
238	R:R:F385	R:R:T162	7.78	No	No	0	5	6
239	R:R:A388	R:R:T162	3.36	No	No	0	8	6
240	R:R:F188	R:R:L163	6.09	No	No	0	8	8
241	R:R:I192	R:R:L163	4.28	No	No	0	7	8
242	R:R:F393	R:R:I165	3.77	No	No	0	8	5
243	R:R:A388	R:R:S166	3.42	No	No	0	8	9
244	R:R:C392	R:R:S166	6.89	No	No	0	9	9
245	R:R:F393	R:R:S166	3.96	No	No	0	8	9
246	R:R:F188	R:R:L167	3.65	No	No	0	8	6
247	R:R:F170	R:R:V181	6.55	No	No	0	8	9
248	R:R:F170	R:R:H184	5.66	No	Yes	0	8	9
249	R:R:F170	R:R:K185	3.72	No	No	0	8	6
250	R:R:F172	R:R:F173	15	No	Yes	0	2	7
251	R:R:F173	R:R:L176	3.65	Yes	No	0	7	9
252	R:R:F173	R:R:T401	5.19	Yes	No	0	7	7
253	R:R:F173	R:R:V402	3.93	Yes	No	0	7	5
254	R:R:C178	R:R:V181	3.42	No	No	0	8	9
255	R:R:Q179	R:R:Y243	6.76	No	Yes	0	7	8
256	R:R:K256	R:R:Q179	5.42	No	No	0	5	7
257	R:R:L259	R:R:Q179	3.99	No	No	0	5	7
258	R:R:H184	R:R:R180	10.16	Yes	No	0	9	9
259	R:R:E240	R:R:L183	5.3	No	No	0	9	8
260	R:R:L183	R:R:Y243	4.69	No	Yes	0	8	8
261	R:R:E240	R:R:H184	11.08	No	Yes	0	9	9
262	R:R:H184	R:R:Y391	5.44	Yes	No	0	9	8
263	R:R:N186	R:R:W236	13.56	No	Yes	2	9	9
264	R:R:N186	R:R:Y263	5.81	No	No	2	9	5
265	R:R:M187	R:R:Y191	4.79	No	Yes	0	8	8
266	R:R:M187	R:R:W236	3.49	No	Yes	0	8	9
267	R:R:E240	R:R:M187	5.41	No	No	0	9	8
268	R:R:L189	R:R:L193	4.15	No	No	0	3	6
269	R:R:N233	R:R:T190	7.31	Yes	No	2	9	9
270	R:R:T190	R:R:W236	4.85	No	Yes	2	9	9
271	R:R:T190	R:R:W267	6.06	No	No	2	9	9
272	R:R:N233	R:R:Y191	13.96	Yes	Yes	2	9	8
273	R:R:M237	R:R:Y191	4.79	Yes	Yes	2	9	8
274	R:R:Q383	R:R:Y191	7.89	No	Yes	2	9	8
275	R:R:G384	R:R:Y191	4.35	No	Yes	0	9	8
276	R:R:L193	R:R:M229	7.07	No	No	0	6	4
277	R:R:I198	R:R:N194	5.66	Yes	No	0	7	8
278	R:R:N194	R:R:N233	4.09	No	Yes	0	8	9
279	R:R:H226	R:R:I197	3.98	No	No	0	6	5
280	R:R:H226	R:R:I198	6.63	No	Yes	0	6	7
281	R:R:H201	R:R:V205	9.69	Yes	No	0	6	7
282	R:R:P207	R:R:V206	7.07	No	No	0	3	3
283	R:R:E210	R:R:N208	5.26	No	No	0	3	3
284	R:R:L211	R:R:N208	5.49	No	No	0	1	3
285	R:R:E210	R:R:R213	5.82	No	No	0	3	2
286	R:R:E210	R:R:R214	10.47	No	No	0	3	4
287	R:R:L211	R:R:P216	3.28	No	No	0	1	4
288	R:R:C289	R:R:V212	8.54	No	No	0	9	3
289	R:R:D215	R:R:K220	6.91	No	No	0	6	7
290	R:R:D215	R:R:N288	17.5	No	No	0	6	4
291	R:R:I221	R:R:V217	4.61	No	No	0	4	3
292	R:R:C219	R:R:C289	7.28	No	No	0	9	9
293	R:R:K220	R:R:N286	4.2	No	No	6	7	7
294	R:R:K220	R:R:W290	23.21	No	Yes	6	7	9
295	R:R:F225	R:R:I221	3.77	No	No	0	5	4
296	R:R:H223	R:R:Q227	14.84	No	No	0	5	7
297	R:R:H223	R:R:R281	5.64	No	Yes	0	5	7
298	R:R:F224	R:R:T274	6.49	No	No	0	5	6
299	R:R:H226	R:R:Q227	6.18	No	No	0	6	7
300	R:R:I301	R:R:Q227	4.12	No	No	0	7	7
301	R:R:C232	R:R:Y228	9.41	No	No	0	8	8
302	R:R:L271	R:R:Y228	9.38	No	No	0	4	8
303	R:R:M230	R:R:Y234	3.59	No	Yes	0	6	7
304	R:R:H302	R:R:M230	5.25	No	No	0	6	6
305	R:R:A231	R:R:P270	3.74	No	Yes	0	5	9
306	R:R:C232	R:R:W267	5.22	No	No	0	8	9
307	R:R:C232	R:R:P270	7.53	No	Yes	0	8	9
308	R:R:M237	R:R:N233	7.01	Yes	Yes	2	9	9
309	R:R:M237	R:R:Y234	3.59	Yes	Yes	2	9	7
310	R:R:V305	R:R:Y234	16.4	No	Yes	0	7	7
311	R:R:L309	R:R:Y234	3.52	No	Yes	2	7	7
312	R:R:F356	R:R:Y234	12.38	Yes	Yes	2	7	7
313	R:R:F235	R:R:F269	8.57	No	Yes	9	5	3
314	R:R:F235	R:R:P270	4.33	No	Yes	9	5	9
315	R:R:W236	R:R:Y263	3.86	Yes	No	2	9	5
316	R:R:G266	R:R:W236	7.04	No	Yes	0	9	9
317	R:R:W236	R:R:W267	18.74	Yes	No	2	9	9
318	R:R:M237	R:R:Q383	5.44	Yes	No	2	9	9
319	R:R:I242	R:R:L238	7.14	Yes	No	0	7	8
320	R:R:A308	R:R:L238	6.3	No	No	0	7	8
321	R:R:L238	R:R:N312	4.12	No	No	0	8	9
322	R:R:C239	R:R:L265	4.76	No	No	0	7	7
323	R:R:G241	R:R:N312	5.09	No	No	0	8	9
324	R:R:F315	R:R:I242	3.77	No	Yes	0	8	7
325	R:R:T246	R:R:Y243	3.75	No	Yes	0	7	8
326	R:R:Y243	R:R:Y262	3.97	Yes	No	0	8	7
327	R:R:I319	R:R:L244	4.28	No	No	0	9	9
328	R:R:L244	R:R:L348	4.15	No	No	0	9	9
329	R:R:H245	R:R:V249	6.92	No	Yes	0	8	6
330	R:R:F315	R:R:H245	28.28	No	No	0	8	8
331	R:R:H245	R:R:N318	5.1	No	No	0	8	8
332	R:R:A251	R:R:T254	5.03	No	No	0	6	6
333	R:R:Q257	R:R:Y262	5.64	No	No	0	5	7
334	R:R:R258	R:R:R260	10.66	No	No	0	5	3
335	R:R:L259	R:R:Y263	5.86	No	No	0	5	5
336	R:R:F269	R:R:P270	4.33	Yes	Yes	9	3	9
337	R:R:P273	R:R:V272	3.53	No	No	0	6	4
338	R:R:H277	R:R:R281	12.41	No	Yes	0	7	7
339	R:R:H277	R:R:L298	3.86	No	No	0	7	6
340	R:R:H277	R:R:I301	10.61	No	No	0	7	7
341	R:R:L297	R:R:T280	5.9	No	No	0	4	4
342	R:R:D287	R:R:R281	10.72	Yes	Yes	6	3	7
343	R:R:R281	R:R:W290	19.99	Yes	Yes	6	7	9
344	R:R:V283	R:R:Y284	5.05	No	No	0	3	2
345	R:R:D287	R:R:F285	9.55	Yes	No	0	3	6
346	R:R:F285	R:R:T295	11.67	No	No	0	6	4
347	R:R:N286	R:R:W290	4.52	No	Yes	6	7	9
348	R:R:D287	R:R:W290	3.35	Yes	Yes	6	3	9
349	R:R:D287	R:R:S292	4.42	Yes	No	0	3	4
350	R:R:C289	R:R:L291	7.94	No	No	0	9	6
351	R:R:E294	R:R:V293	5.7	No	No	0	3	6
352	R:R:L297	R:R:T295	4.42	No	No	0	4	4
353	R:R:G303	R:R:P304	4.06	No	Yes	0	4	9
354	R:R:F356	R:R:L309	3.65	Yes	No	2	7	7
355	R:R:F315	R:R:V311	5.24	No	No	0	8	6
356	R:R:L352	R:R:N312	5.49	No	No	0	9	9
357	R:R:F313	R:R:L317	8.53	No	No	0	6	5
358	R:R:F313	R:R:I354	5.02	No	No	0	6	6
359	R:R:L316	R:R:L348	4.15	No	No	0	9	9
360	R:R:I354	R:R:L316	5.71	No	No	0	6	9
361	R:R:N318	R:R:R321	4.82	No	No	0	8	8
362	R:R:M327	R:R:M337	4.33	No	No	0	7	7
363	R:R:K340	R:R:M327	5.76	No	No	0	8	7
364	R:R:E332	R:R:T330	4.23	No	No	0	5	5
365	R:R:A333	R:R:H336	4.39	No	No	0	5	6
366	R:R:E334	R:R:Y338	7.86	No	No	0	6	7
367	R:R:P350	R:R:V349	3.53	No	No	0	9	8
368	R:R:L351	R:R:L352	4.15	No	No	0	9	9
369	R:R:L351	R:R:Y391	17.58	No	No	0	9	8
370	R:R:I354	R:R:L352	5.71	No	No	0	6	9
371	R:R:F356	R:R:Q355	14.05	Yes	Yes	2	7	8
372	R:R:L379	R:R:Q355	13.31	No	Yes	0	5	8
373	R:R:I380	R:R:Q355	4.12	No	Yes	2	6	8
374	R:R:Q355	R:R:Q383	14.08	Yes	No	2	8	9
375	R:R:F356	R:R:M376	3.73	Yes	Yes	2	7	7
376	R:R:F356	R:R:I380	7.54	Yes	No	2	7	6
377	R:R:F359	R:R:V358	11.8	Yes	No	0	6	5
378	R:R:F359	R:R:Y372	5.16	Yes	Yes	2	6	7
379	R:R:F359	R:R:M376	3.73	Yes	Yes	2	6	7
380	R:R:G369	R:R:R362	6	No	Yes	0	4	4
381	R:R:R362	R:R:Y372	6.17	Yes	Yes	2	4	7
382	R:R:D373	R:R:R362	15.48	No	Yes	0	5	4
383	R:R:L368	R:R:P363	3.28	No	No	0	3	7
384	R:R:P363	R:R:Y372	11.13	No	Yes	0	7	7
385	R:R:L368	R:R:N365	10.98	No	No	0	3	4
386	R:R:K370	R:R:Y374	3.58	No	Yes	4	4	6
387	R:R:M376	R:R:Y372	8.38	Yes	Yes	2	7	7
388	R:R:I380	R:R:M376	5.83	No	Yes	2	6	7
389	R:R:H377	R:R:H381	9.55	Yes	Yes	0	7	9
390	R:R:F385	R:R:F386	5.36	No	No	0	5	5
391	R:R:F393	R:R:T389	3.89	No	No	0	8	5
392	R:R:I390	R:R:Y391	7.25	No	No	0	8	8
393	R:R:E397	R:R:N395	10.52	No	No	0	9	9
394	R:R:N395	R:R:V398	8.87	No	No	0	9	9
395	R:R:R404	R:R:T400	3.88	No	No	0	7	4
396	R:R:V402	R:R:W406	3.68	No	No	0	5	6
397	R:R:Q405	R:R:W406	4.38	No	No	0	4	6
398	R:R:C392	R:R:I169	3.27	No	No	0	9	8
399	E:E:N113	E:E:P114	3.26	Yes	No	0	9	5
400	R:R:C55	R:R:M59	3.24	No	No	0	9	5
401	L:L:A5	R:R:M376	3.22	No	Yes	0	0	7
402	R:R:D103	R:R:P104	3.22	No	No	0	3	3
403	R:R:F382	R:R:F386	3.22	No	No	0	7	5
404	E:E:P136	E:E:Q135	3.16	No	No	0	6	5
405	E:E:A116	E:E:L100	3.15	No	No	0	9	8
406	L:L:L16	R:R:A145	3.15	No	No	0	0	4
407	R:R:A388	R:R:L163	3.15	No	No	0	8	8
408	R:R:A344	R:R:L323	3.15	No	No	0	9	9
409	R:R:E294	R:R:P104	3.14	No	No	0	3	3
410	R:R:C219	R:R:D215	3.11	No	No	0	9	6
411	R:R:F39	R:R:Y41	3.09	No	No	0	4	3
412	E:E:I119	E:E:V65	3.07	No	No	0	5	5
413	R:R:I248	R:R:V249	3.07	No	Yes	0	7	6
414	R:R:I276	R:R:V272	3.07	No	No	0	5	4
415	E:E:M149	E:E:V145	3.04	No	No	0	9	7
416	R:R:M337	R:R:V324	3.04	No	No	0	7	5
417	R:R:F356	R:R:G353	3.01	Yes	No	0	7	9
418	E:E:R167	R:R:W261	3	No	Yes	0	8	2
419	L:L:L16	L:L:S20	3	No	No	0	0	0
420	R:R:K120	R:R:T127	3	No	No	0	1	4
421	R:R:L176	R:R:S175	3	No	No	0	9	8
422	E:E:L100	E:E:V65	2.98	No	No	0	8	5
423	E:E:V164	R:R:L265	2.98	No	No	0	9	7
424	R:R:L316	R:R:V320	2.98	No	No	0	9	7
425	R:R:L259	R:R:T182	2.95	No	No	0	5	5
426	E:E:I161	R:R:I242	2.94	No	Yes	10	9	7
427	R:R:I197	R:R:M229	2.92	No	No	0	5	4
428	E:E:S168	R:R:Q257	2.89	No	No	0	9	5
429	R:R:F235	R:R:P304	2.89	No	Yes	0	5	9
430	E:E:P92	E:E:R91	2.88	No	No	0	6	6
431	E:E:I151	E:E:L147	2.85	No	No	0	6	7
432	R:R:I198	R:R:L202	2.85	Yes	No	0	7	7
433	E:E:C68	E:E:F103	2.79	No	No	0	9	1
434	R:R:H201	R:R:V206	2.77	Yes	No	0	6	3
435	R:R:A278	R:R:F224	2.77	No	No	0	6	5
436	R:R:F314	R:R:V310	2.62	No	No	0	5	4
437	R:R:F313	R:R:V357	2.62	No	No	0	6	7
438	R:R:R328	R:R:V324	2.62	No	No	0	6	5
439	E:E:D144	E:E:E143	2.6	No	No	0	7	7
440	E:E:R91	E:E:T95	2.59	No	No	0	6	2
441	R:R:A278	R:R:W290	2.59	No	Yes	0	6	9
442	R:R:A282	R:R:W290	2.59	No	Yes	0	3	9
443	R:R:H201	R:R:L222	2.57	Yes	No	0	6	6
444	R:R:H201	R:R:L291	2.57	Yes	No	0	6	6
445	R:R:V147	R:R:Y374	2.52	No	Yes	0	4	6
446	R:R:V387	R:R:Y191	2.52	No	Yes	0	9	8
447	R:R:F173	R:R:I169	2.51	Yes	No	0	7	8
448	R:R:F137	R:R:M133	2.49	Yes	No	0	1	5
449	R:R:M48	R:R:R45	2.48	No	No	0	6	7
450	R:R:K256	R:R:R258	2.48	No	No	0	5	5
451	R:R:F382	R:R:L151	2.44	No	No	0	7	5
452	R:R:M337	R:R:Y338	2.39	No	No	0	7	7
453	R:R:L247	R:R:Y243	2.34	No	Yes	0	8	8
454	R:R:L264	R:R:W261	2.28	No	Yes	0	3	2
455	E:E:F67	E:E:H71	2.26	No	No	0	1	1
456	R:R:G268	R:R:P270	2.03	No	Yes	0	6	9
457	E:E:P153	R:R:P273	1.95	No	No	0	9	6
458	E:E:P153	R:R:P304	1.95	No	Yes	0	9	9
459	L:L:P28	L:L:P29	1.95	No	No	0	0	0
460	R:R:C219	R:R:P216	1.88	No	No	0	9	4
461	E:E:A152	E:E:P153	1.87	No	No	0	7	9
462	R:R:A87	R:R:P70	1.87	No	No	0	4	1
463	R:R:G44	R:R:V43	1.84	No	No	0	4	2
464	R:R:P216	R:R:S218	1.78	No	No	0	4	3
465	R:R:P350	R:R:V387	1.77	No	No	0	9	9
466	R:R:P86	R:R:T85	1.75	No	No	0	2	7
467	R:R:G44	R:R:K47	1.74	No	No	0	4	4
468	R:R:G168	R:R:L167	1.71	No	No	0	1	6
469	L:L:A13	R:R:V206	1.7	No	No	0	0	3
470	L:L:G24	L:L:N21	1.7	No	No	0	0	0
471	L:L:G24	L:L:N22	1.7	No	No	0	0	0
472	R:R:A341	R:R:V324	1.7	No	No	0	9	5
473	E:E:I89	E:E:P92	1.69	No	No	0	8	6
474	L:L:L27	L:L:P28	1.64	No	No	0	0	0
475	R:R:L62	R:R:P63	1.64	No	No	0	3	1
476	R:R:D101	R:R:P100	1.61	Yes	No	0	4	4
477	L:L:S19	R:R:T138	1.6	No	No	0	0	2
478	R:R:V249	R:R:V250	1.6	Yes	No	0	6	5
479	R:R:V249	R:R:V322	1.6	Yes	No	0	6	8
480	R:R:V310	R:R:V357	1.6	No	No	0	4	7
481	R:R:V398	R:R:V402	1.6	No	No	0	9	5
482	R:R:T345	R:R:V320	1.59	No	No	0	9	7
483	R:R:T345	R:R:V349	1.59	No	No	0	9	8
484	E:E:E143	E:E:P142	1.57	No	No	0	7	9
485	R:R:E140	R:R:P139	1.57	No	No	0	2	3
486	R:R:T274	R:R:T275	1.57	No	No	0	6	3
487	E:E:I161	E:E:V165	1.54	No	No	10	9	9
488	E:E:V165	R:R:I242	1.54	No	Yes	10	9	7
489	R:R:I153	R:R:V203	1.54	No	No	0	7	3
490	R:R:I165	R:R:V164	1.54	No	No	0	5	4
491	R:R:I199	R:R:V203	1.54	No	No	0	7	3
492	E:E:S90	R:R:K46	1.53	No	No	0	7	4
493	R:R:K46	R:R:V42	1.52	No	No	0	4	1
494	R:R:K120	R:R:V117	1.52	No	No	0	1	5
495	R:R:K185	R:R:V171	1.52	No	No	0	6	4
496	R:R:I279	R:R:T275	1.52	No	No	0	3	3
497	R:R:K326	R:R:V322	1.52	No	No	0	9	8
498	R:R:M346	R:R:V342	1.52	No	No	0	8	8
499	E:E:G110	R:R:R126	1.5	No	No	0	5	4
500	R:R:L151	R:R:S378	1.5	No	No	0	5	5
501	R:R:D113	R:R:V117	1.46	No	No	0	5	5
502	R:R:I200	R:R:M196	1.46	No	No	0	6	4
503	R:R:I371	R:R:M367	1.46	No	No	0	5	4
504	R:R:N396	R:R:T400	1.46	No	No	0	6	4
505	E:E:F159	E:E:P158	1.44	No	No	0	8	9
506	R:R:F359	R:R:P360	1.44	Yes	No	0	6	5
507	R:R:I200	R:R:L222	1.43	No	No	0	6	6
508	R:R:I347	R:R:L348	1.43	No	No	0	8	9
509	R:R:L323	R:R:M327	1.41	No	No	0	9	7
510	E:E:C155	E:E:F159	1.4	No	No	0	7	8
511	R:R:K120	R:R:N125	1.4	No	No	0	1	7
512	R:R:M367	R:R:N365	1.4	No	No	0	4	4
513	E:E:I126	E:E:Q125	1.37	No	No	0	5	5
514	L:L:T9	R:R:H381	1.37	No	Yes	0	0	9
515	E:E:D74	E:E:N70	1.35	No	No	0	1	2
516	R:R:D84	R:R:N73	1.35	No	No	0	4	4
517	R:R:E140	R:R:K143	1.35	No	No	0	2	1
518	R:R:E255	R:R:K256	1.35	No	No	0	6	5
519	R:R:A51	R:R:Y98	1.33	No	Yes	0	8	4
520	R:R:N396	R:R:Q399	1.32	No	No	0	6	7
521	R:R:E397	R:R:N396	1.31	No	No	0	9	6
522	E:E:E101	E:E:E105	1.27	No	No	0	8	5
523	E:E:H71	E:E:Q75	1.24	No	No	0	1	3
524	R:R:E332	R:R:H336	1.23	No	No	0	5	6
525	R:R:F39	R:R:L40	1.22	No	No	0	4	5
526	E:E:E122	E:E:F121	1.17	No	No	0	4	6
527	R:R:L148	R:R:Y374	1.17	No	Yes	4	5	6
528	E:E:E117	E:E:R118	1.16	No	No	0	8	4
529	R:R:F224	R:R:F225	1.07	No	No	0	5	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	E:E:Y61	6.5475	4	5	8
2	E:E:W69	6.5325	4	3	6
3	E:E:Y72	8.8	5	3	9
4	E:E:R97	8.335	4	0	7
5	E:E:F111	5.0125	4	0	8
6	E:E:N113	5.882	5	5	9
7	E:E:H127	7.95	6	3	8
8	E:E:F128	6.4925	4	0	9
9	E:E:P141	7.2725	4	0	9
10	L:L:T6	6.3725	4	2	0
11	L:L:T36	4.5975	4	1	0
12	L:L:?38	6.2	5	1	0
13	R:R:Y56	9.8375	4	0	3
14	R:R:R74	9.6775	4	0	4
15	R:R:W76	9.532	5	12	8
16	R:R:W79	13.9775	4	1	6
17	R:R:L80	7.915	4	1	5
18	R:R:W82	9.62167	6	1	9
19	R:R:Y98	7.39833	6	1	4
20	R:R:F99	9.274	5	1	5
21	R:R:D101	5.394	5	1	4
22	R:R:F102	7.5	6	1	4
23	R:R:W118	7.61667	6	1	9
24	R:R:H121	7.8675	4	11	4
25	R:R:N124	6.3575	4	11	5
26	R:R:W128	8.0825	4	0	5
27	R:R:S129	5.466	5	1	7
28	R:R:Y131	8.77429	7	1	5
29	R:R:F137	7.245	4	14	1
30	R:R:Y149	6.35	4	0	5
31	R:R:H156	7.2825	4	0	7
32	R:R:F173	6.056	5	0	7
33	R:R:H184	8.085	4	0	9
34	R:R:Y191	6.38333	6	2	8
35	R:R:I198	6.4375	4	0	7
36	R:R:H201	4.51	5	0	6
37	R:R:N233	8.0925	4	2	9
38	R:R:Y234	8.03667	6	2	7
39	R:R:W236	8.59	6	2	9
40	R:R:M237	5.2075	4	2	9
41	R:R:I242	3.8475	4	10	7
42	R:R:Y243	4.302	5	0	8
43	R:R:V249	3.2975	4	0	6
44	R:R:W261	5.1425	4	0	2
45	R:R:F269	5.6975	4	9	3
46	R:R:P270	4.392	5	9	9
47	R:R:R281	12.19	4	6	7
48	R:R:D287	7.01	4	6	3
49	R:R:W290	9.375	6	6	9
50	R:R:P304	3.495	4	0	9
51	R:R:Q355	11.39	4	2	8
52	R:R:F356	7.07857	7	2	7
53	R:R:F359	5.5325	4	2	6
54	R:R:R362	7.106	5	2	4
55	R:R:Y372	7.71	4	2	7
56	R:R:Y374	3.27	4	4	6
57	R:R:M376	4.978	5	2	7
58	R:R:H377	8.6275	4	4	7
59	R:R:H381	5.755	4	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	E:E:F111	E:E:R97	26.5004	4.28	Yes	Yes	0	8	7
2	E:E:R97	R:R:M49	29.4315	8.69	Yes	No	0	7	4
3	E:E:Y93	R:R:M49	28.6791	3.59	No	No	0	9	4
4	E:E:H124	E:E:Y93	55.8089	8.71	No	No	0	9	9
5	E:E:F128	E:E:H124	54.6453	6.79	Yes	No	0	9	9
6	E:E:F128	E:E:I89	15.7275	7.54	Yes	No	0	9	8
7	E:E:I89	E:E:P92	14.1588	1.69	No	No	0	8	6
8	E:E:R97	R:R:Q52	47.2384	11.68	Yes	No	0	7	6
9	E:E:Y93	R:R:Q52	28.6855	7.89	No	No	0	9	6
10	E:E:F128	E:E:H127	29.804	3.39	Yes	Yes	0	9	8
11	E:E:R97	R:R:M48	52.4547	8.69	Yes	No	0	7	6
12	E:E:F111	E:E:P112	30.4026	5.78	Yes	No	0	8	9
13	E:E:P112	R:R:R126	30.5877	4.32	No	No	0	9	4
14	R:R:Q52	R:R:W76	17.8418	14.24	No	Yes	0	6	8
15	R:R:C55	R:R:W76	12.7252	10.45	No	Yes	12	9	8
16	R:R:C55	R:R:M59	11.9434	3.24	No	No	0	9	5
17	R:R:M59	R:R:R74	11.1533	12.41	No	Yes	0	5	4
18	R:R:N124	R:R:R126	31.1678	7.23	Yes	No	0	5	4
19	R:R:H121	R:R:N124	31.5321	3.83	Yes	Yes	11	4	5
20	R:R:H121	R:R:W128	32.2386	11.64	Yes	Yes	0	4	5
21	R:R:N130	R:R:W128	99.0391	9.04	No	Yes	0	8	5
22	R:R:N130	R:R:T109	99.1438	4.39	No	No	0	8	5
23	R:R:T109	R:R:Y92	98.6256	6.24	No	No	13	5	4
24	R:R:K107	R:R:Y92	99.3895	8.36	No	No	0	3	4
25	R:R:F94	R:R:K107	99.4359	3.72	No	No	0	3	3
26	L:L:K1	R:R:F94	99.4791	7.44	No	No	0	0	3
27	L:L:K1	R:R:E294	99.5333	8.1	No	No	0	0	3
28	R:R:E294	R:R:V293	99.8966	5.7	No	No	0	3	6
29	L:L:C2	R:R:V293	100	3.42	No	No	0	0	6
30	L:L:C2	R:R:L298	50.6973	4.76	No	No	0	0	6
31	R:R:H277	R:R:L298	50.5985	3.86	No	No	0	7	6
32	R:R:H277	R:R:R281	12.5929	12.41	No	Yes	0	7	7
33	R:R:H277	R:R:I301	37.968	10.61	No	No	0	7	7
34	R:R:I301	R:R:Q227	37.8288	4.12	No	No	0	7	7
35	R:R:H226	R:R:Q227	43.3708	6.18	No	No	0	6	7
36	R:R:H226	R:R:I198	42.7047	6.63	No	Yes	0	6	7
37	R:R:I198	R:R:N194	30.4338	5.66	Yes	No	0	7	8
38	R:R:N194	R:R:N233	30.2354	4.09	No	Yes	0	8	9
39	L:L:C2	L:L:C7	50.8865	7.28	No	No	0	0	0
40	L:L:C7	L:L:R11	50.7749	4.18	No	No	0	0	0
41	L:L:R11	R:R:R362	50.1323	4.26	No	Yes	2	0	4
42	R:R:R362	R:R:Y372	50.3633	6.17	Yes	Yes	2	4	7
43	R:R:M376	R:R:Y372	49.3794	8.38	Yes	Yes	2	7	7
44	R:R:F356	R:R:M376	33.923	3.73	Yes	Yes	2	7	7
45	R:R:F356	R:R:Y234	17.0449	12.38	Yes	Yes	2	7	7
46	R:R:M237	R:R:Y234	17.523	3.59	Yes	Yes	2	9	7
47	R:R:M237	R:R:Y191	15.529	4.79	Yes	Yes	2	9	8
48	R:R:M187	R:R:Y191	48.362	4.79	No	Yes	0	8	8
49	R:R:E240	R:R:M187	47.6298	5.41	No	No	0	9	8
50	R:R:E240	R:R:L183	14.2833	5.3	No	No	0	9	8
51	R:R:L183	R:R:Y243	13.3618	4.69	No	Yes	0	8	8
52	R:R:Y243	R:R:Y262	10.4285	3.97	Yes	No	0	8	7
53	R:R:F356	R:R:Q355	15.761	14.05	Yes	Yes	2	7	8
54	R:R:Q355	R:R:Q383	31.1472	14.08	Yes	No	2	8	9
55	R:R:Q383	R:R:Y191	30.6506	7.89	No	Yes	2	9	8
56	R:R:I380	R:R:M376	15.9034	5.83	No	Yes	2	6	7
57	R:R:I380	R:R:Q355	15.8184	4.12	No	Yes	2	6	8
58	R:R:N233	R:R:Y191	19.5317	13.96	Yes	Yes	2	9	8
59	R:R:E240	R:R:H184	33.3098	11.08	No	Yes	0	9	9
60	R:R:H184	R:R:Y391	26.9658	5.44	Yes	No	0	9	8
61	R:R:L351	R:R:Y391	25.1468	17.58	No	No	0	9	8
62	R:R:L351	R:R:L352	24.2368	4.15	No	No	0	9	9
63	R:R:L352	R:R:N312	17.7426	5.49	No	No	0	9	9
64	R:R:L238	R:R:N312	15.8905	4.12	No	No	0	8	9
65	R:R:I242	R:R:L238	14.0348	7.14	Yes	No	0	7	8
66	R:R:H156	R:R:I198	16.6025	10.61	Yes	Yes	0	7	7
67	R:R:R281	R:R:W290	10.3853	19.99	Yes	Yes	6	7	9
68	R:R:M48	R:R:Y98	54.2765	13.17	No	Yes	0	6	4
69	R:R:W79	R:R:Y98	54.4712	4.82	Yes	Yes	1	6	4
70	L:L:P37	R:R:W79	28.9814	25.67	No	Yes	1	0	6
71	R:R:W79	R:R:Y131	29.9446	16.4	Yes	Yes	1	6	5
72	L:L:?38	L:L:P37	28.9726	12.19	Yes	No	1	0	0
73	L:L:?38	R:R:Y131	32.9156	5.8	Yes	Yes	1	0	5
74	L:L:?38	R:R:W128	67.1583	5.64	Yes	Yes	0	0	5
75	R:R:H156	R:R:S195	12.5856	9.76	Yes	No	0	7	7
76	R:R:I160	R:R:S195	12.2888	6.19	No	No	0	5	7
77	R:R:I160	R:R:I192	11.9912	4.42	No	No	0	5	7
78	R:R:I192	R:R:L163	11.6926	4.28	No	No	0	7	8
79	R:R:A388	R:R:L163	10.4891	3.15	No	No	0	8	8
80	R:R:V387	R:R:Y191	14.665	2.52	No	Yes	0	9	8
81	R:R:P350	R:R:V387	13.7399	1.77	No	No	0	9	9
82	R:R:P350	R:R:V349	12.8184	3.53	No	No	0	9	8
83	R:R:T345	R:R:V349	11.8975	1.59	No	No	0	9	8
84	R:R:T345	R:R:V320	10.9797	1.59	No	No	0	9	7
85	R:R:L316	R:R:V320	10.0739	2.98	No	No	0	9	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
E:E:G110	L:L:N35	5.09	0	No	No	5	0	1	0
E:E:D140	R:R:H296	6.3	0	No	No	9	2	2	1
L:L:?0	R:R:H296	3.46	8	No	No	0	2	0	1
L:L:?0	R:R:Y299	9.45	8	No	No	0	7	0	1
L:L:K1	R:R:F94	7.44	0	No	No	0	3	0	1
L:L:K1	R:R:E294	8.1	0	No	No	0	3	0	1
L:L:C2	R:R:V293	3.42	0	No	No	0	6	0	1
L:L:C2	R:R:L298	4.76	0	No	No	0	6	0	1
L:L:N3	R:R:W361	19.21	2	No	No	0	4	0	1
L:L:N3	R:R:R362	3.62	2	No	Yes	0	4	0	1
L:L:T4	R:R:M306	4.52	0	No	No	0	4	0	1
L:L:T6	R:R:Y234	8.74	2	Yes	Yes	0	7	0	1
L:L:T6	R:R:H302	6.85	2	Yes	No	0	6	0	1
L:L:T6	R:R:F356	5.19	2	Yes	Yes	0	7	0	1
L:L:A8	R:R:H377	4.39	0	No	Yes	0	7	0	1
L:L:Q10	R:R:H201	4.95	0	No	Yes	0	6	0	1
L:L:R11	R:R:R362	4.26	2	No	Yes	0	4	0	1
L:L:L12	R:R:L148	5.54	4	No	No	0	5	0	1
L:L:L12	R:R:H377	6.43	4	No	Yes	0	7	0	1
L:L:E14	R:R:V293	5.7	0	No	No	0	6	0	1
L:L:F15	R:R:K141	13.65	0	No	No	0	3	0	1
L:L:F15	R:R:L142	3.65	0	No	No	0	2	0	1
L:L:L16	R:R:Y149	3.52	0	No	Yes	0	5	0	1
L:L:H18	R:R:D97	7.56	0	No	No	0	2	0	1
L:L:S20	R:R:Y146	5.09	0	No	No	0	2	0	1
L:L:F23	R:R:Y146	7.22	0	No	No	0	2	0	1
L:L:T30	R:R:F99	16.86	1	No	Yes	0	5	0	1
L:L:T30	R:R:D101	10.12	1	No	Yes	0	4	0	1
L:L:T30	R:R:F102	3.89	1	No	Yes	0	4	0	1
L:L:V32	R:R:Y131	5.05	0	No	Yes	0	5	0	1
L:L:V32	R:R:N135	4.43	0	No	No	0	3	0	1
L:L:S34	R:R:H121	8.37	11	No	Yes	0	4	0	1
L:L:S34	R:R:N124	10.43	11	No	Yes	0	5	0	1
L:L:P37	R:R:W79	25.67	1	No	Yes	0	6	0	1
L:L:?38	R:R:W128	5.64	1	Yes	Yes	0	5	0	1
L:L:?38	R:R:S129	3.72	1	Yes	Yes	0	7	0	1
L:L:?38	R:R:Y131	5.8	1	Yes	Yes	0	5	0	1
L:L:?101	R:R:H296	12.48	8	No	No	0	2	0	1
R:R:D77	R:R:W82	11.17	1	No	Yes	9	9	2	2
R:R:D77	R:R:S129	5.89	1	No	Yes	9	7	2	1
R:R:D77	R:R:Y131	6.9	1	No	Yes	9	5	2	1
R:R:W79	R:R:Y98	4.82	1	Yes	Yes	6	4	1	2
R:R:F99	R:R:W79	9.02	1	Yes	Yes	5	6	1	1
R:R:W79	R:R:Y131	16.4	1	Yes	Yes	6	5	1	1
R:R:L80	R:R:W82	3.42	1	Yes	Yes	5	9	2	2
R:R:L80	R:R:P96	6.57	1	Yes	No	5	9	2	2
R:R:L80	R:R:Y131	7.03	1	Yes	Yes	5	5	2	1
R:R:K110	R:R:W82	29.01	1	No	Yes	8	9	2	2
R:R:S129	R:R:W82	3.71	1	Yes	Yes	7	9	1	2
R:R:F94	R:R:K107	3.72	0	No	No	3	3	1	2
R:R:P96	R:R:Y98	15.3	0	No	Yes	9	4	2	2
R:R:F102	R:R:P96	5.78	1	Yes	No	4	9	1	2
R:R:F99	R:R:Y98	6.19	1	Yes	Yes	5	4	1	2
R:R:D101	R:R:F99	3.58	1	Yes	Yes	4	5	1	1
R:R:F102	R:R:F99	10.72	1	Yes	Yes	4	5	1	1
R:R:D101	R:R:F102	3.58	1	Yes	Yes	4	4	1	1
R:R:D101	R:R:N135	8.08	1	Yes	No	4	3	1	1
R:R:C134	R:R:F102	12.57	0	No	Yes	9	4	2	1
R:R:F102	R:R:N135	8.46	1	Yes	No	4	3	1	1
R:R:V108	R:R:Y131	13.88	0	No	Yes	7	5	2	1
R:R:K110	R:R:S129	7.65	1	No	Yes	8	7	2	1
R:R:F119	R:R:W128	6.01	0	No	Yes	4	5	2	1
R:R:H121	R:R:P122	7.63	11	Yes	No	4	5	1	2
R:R:H121	R:R:N124	3.83	11	Yes	Yes	4	5	1	1
R:R:H121	R:R:W128	11.64	11	Yes	Yes	4	5	1	1
R:R:E123	R:R:N124	3.94	0	No	Yes	4	5	2	1
R:R:N124	R:R:R126	7.23	11	Yes	No	5	4	1	2
R:R:N130	R:R:W128	9.04	0	No	Yes	8	5	2	1
R:R:S129	R:R:Y131	6.36	1	Yes	Yes	7	5	1	1
R:R:P139	R:R:T138	3.5	0	No	No	3	2	2	1
R:R:L142	R:R:Y146	7.03	0	No	No	2	2	1	1
R:R:H377	R:R:L148	14.14	4	Yes	No	7	5	1	1
R:R:Y149	R:R:Y150	3.97	0	Yes	No	5	4	1	2
R:R:I153	R:R:Y149	10.88	0	No	Yes	7	5	2	1
R:R:L202	R:R:Y149	7.03	0	No	Yes	7	5	2	1
R:R:A152	R:R:H381	7.32	0	No	Yes	7	9	2	1
R:R:H156	R:R:H381	4.78	0	Yes	Yes	7	9	2	1
R:R:H201	R:R:V205	9.69	0	Yes	No	6	7	1	2
R:R:P207	R:R:V206	7.07	0	No	No	3	3	2	1
R:R:M230	R:R:Y234	3.59	0	No	Yes	6	7	2	1
R:R:H302	R:R:M230	5.25	0	No	No	6	6	1	2
R:R:M237	R:R:Y234	3.59	2	Yes	Yes	9	7	2	1
R:R:V305	R:R:Y234	16.4	0	No	Yes	7	7	2	1
R:R:L309	R:R:Y234	3.52	2	No	Yes	7	7	2	1
R:R:F356	R:R:Y234	12.38	2	Yes	Yes	7	7	1	1
R:R:H277	R:R:L298	3.86	0	No	No	7	6	2	1
R:R:E294	R:R:V293	5.7	0	No	No	3	6	1	1
R:R:F356	R:R:L309	3.65	2	Yes	No	7	7	1	2
R:R:F356	R:R:Q355	14.05	2	Yes	Yes	7	8	1	2
R:R:I380	R:R:Q355	4.12	2	No	Yes	6	8	2	2
R:R:F356	R:R:M376	3.73	2	Yes	Yes	7	7	1	1
R:R:F356	R:R:I380	7.54	2	Yes	No	7	6	1	2
R:R:F359	R:R:Y372	5.16	2	Yes	Yes	6	7	2	2
R:R:F359	R:R:M376	3.73	2	Yes	Yes	6	7	2	1
R:R:G369	R:R:R362	6	0	No	Yes	4	4	2	1
R:R:R362	R:R:Y372	6.17	2	Yes	Yes	4	7	1	2
R:R:D373	R:R:R362	15.48	0	No	Yes	5	4	2	1
R:R:M376	R:R:Y372	8.38	2	Yes	Yes	7	7	1	2
R:R:I380	R:R:M376	5.83	2	No	Yes	6	7	2	1
R:R:H377	R:R:H381	9.55	4	Yes	Yes	7	9	1	1
L:L:A5	R:R:M376	3.22	0	No	Yes	0	7	0	1
L:L:L16	R:R:A145	3.15	0	No	No	0	4	0	1
R:R:E294	R:R:P104	3.14	0	No	No	3	3	1	2
R:R:F356	R:R:G353	3.01	2	Yes	No	7	9	1	2
R:R:H201	R:R:V206	2.77	0	Yes	No	6	3	1	1
R:R:H201	R:R:L222	2.57	0	Yes	No	6	6	1	2
R:R:H201	R:R:L291	2.57	0	Yes	No	6	6	1	2
L:L:A13	R:R:V206	1.7	0	No	No	0	3	0	1
R:R:D101	R:R:P100	1.61	1	Yes	No	4	4	1	2
L:L:S19	R:R:T138	1.6	0	No	No	0	2	0	1
E:E:G110	R:R:R126	1.5	0	No	No	5	4	1	2
L:L:T9	R:R:H381	1.37	0	No	Yes	0	9	0	1
R:R:L148	R:R:Y374	1.17	4	No	Yes	5	6	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9BQ3_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.28
Number of Linked Nodes	480
Number of Links	529
Number of Hubs	59
Number of Links mediated by Hubs	229
Number of Communities	14
Number of Nodes involved in Communities	90
Number of Links involved in Communities	122

Path Summary
Number Of Nodes in MetaPath	86
Number Of Links MetaPath	85
Number of Shortest Paths	290076
Length Of Smallest Path	3
Average Path Length	29.1064
Length of Longest Path	52
Minimum Path Strength	1.315
Average Path Strength	6.86745
Maximum Path Strength	24.785
Minimum Path Correlation	0.7
Average Path Correlation	0.961407
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	2.63158
Average % Of Corr. Nodes	44.9828
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	31.8498
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like • RAMP1-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like • RAMP1-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	GGL
PDB Residues	L:L:?0
Environment Details	Open EMBL-EBI Page
Code	GGL
Name	Glutamic acid
Synonyms	Glutamic acid
Identifier
Formula	C5 H9 N O4
Molecular Weight	147.129
SMILES
PubChem	33032
Formal Charge	0
Total Atoms	19
Total Chiral Atoms	1
Total Bonds	18
Total Aromatic Bonds	0


Code	NH2
PDB Residues	L:L:?38
Environment Details	Open EMBL-EBI Page
Code	NH2
Name	AMINO GROUP
Synonyms
Identifier
Formula	H2 N
Molecular Weight	16.023
SMILES
PubChem	123329
Formal Charge	0
Total Atoms	3
Total Chiral Atoms	0
Total Bonds	2
Total Aromatic Bonds	0


Code	_L_
PDB Residues	L:L:?101
Environment Details	Open EMBL-EBI Page
Code	_L_
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds


PDBsum	Open PDBsum Page
Chain	E
Protein	RAMP2
UniProt	O60895
Sequence	>9BQ3_nogp_Chain_E N Y E T A V Q F C W N H Y K D Q M D P I E K D W C D W A M I S R P Y S T L R D C L E H F A E L F D L G F P N P L A E R I I F E T H Q I H F A N C S L V Q P T F S D P P E D V L L A M I I A P I C L I P F L I T L V V W R S K D Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	L
Protein	Cagrilintide
UniProt	P10997
Sequence	>9BQ3_nogp_Chain_L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	R
Protein	Receptor
UniProt	P30988
Sequence	>9BQ3_nogp_Chain_R F L Y V V G R K K M M D A Q Y K C Y D R M Q Q L P A Y P Y C N R T W D G W L C W D D T P A G V L S Y Q F C P D Y F P D F D P S E K V T K Y C D V W F K H P E N N R T W S N Y T M C N A F T P E K L K N A Y V L Y Y L A I V G H S L S I F T L V I S L G I F V F F R S L G C Q R V T L H K N M F L T Y I L N S M I I I I H L V E V V P N G E L V R R D P V S C K I L H F F H Q Y M M A C N Y F W M L C E G I Y L H T L I V V A V F T E K Q R L R W Y Y L L G W G F P L V P T T I H A I T R A V Y F N D N C W L S V E T H L L Y I I H G P V M A A L V V N F F F L L N I V R V L V T K M R E T H E A E S H M Y L K A V K A T M I L V P L L G I Q F V V F P W R P S N K M L G K I Y D Y V M H S L I H F Q G F F V A T I Y C F C N N E V Q T T V K R Q W Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7TYH	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Calcitonin	-	Gs/β1/γ2; RAMP2	3.3	2022-03-23	doi.org/10.1126/science.abm9609
	7TYH (No Gprot)	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Calcitonin	-		3.3	2022-03-23	doi.org/10.1126/science.abm9609
	7TYY	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Calcitonin-1	-	Gs/β1/γ2; RAMP2	3	2022-03-23	doi.org/10.1126/science.abm9609
	7TYY (No Gprot)	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Calcitonin-1	-		3	2022-03-23	doi.org/10.1126/science.abm9609
	7TYX	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Amylin	-	Gs/β1/γ2; RAMP2	2.55	2022-03-30	doi.org/10.1126/science.abm9609
	7TYX (No Gprot)	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Amylin	-		2.55	2022-03-30	doi.org/10.1126/science.abm9609
	9BQ3	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Cagrilintide	-	Gs/β1/γ2; RAMP2	2.8	2025-04-23	doi.org/10.1038/s41467-025-58680-y
	9BQ3 (No Gprot)	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Cagrilintide	-		2.8	2025-04-23	doi.org/10.1038/s41467-025-58680-y

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