psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	E:E:F103	E:E:Y61	5.16	Yes	No	0	1	8
2	E:E:F107	E:E:Y61	10.32	No	No	0	5	8
3	E:E:A64	E:E:F103	9.71	No	Yes	0	3	1
4	E:E:C68	E:E:C99	7.28	No	No	8	9	9
5	E:E:N70	E:E:W69	4.52	No	Yes	0	2	6
6	E:E:E122	E:E:W69	6.54	No	Yes	0	4	6
7	E:E:M76	E:E:Y72	14.37	Yes	No	0	9	9
8	E:E:L96	E:E:Y72	10.55	No	No	0	8	9
9	E:E:K73	E:E:M76	8.64	No	Yes	0	5	9
10	E:E:P92	E:E:Q75	7.9	No	No	0	6	3
11	E:E:M76	E:E:W83	13.96	Yes	Yes	1	9	7
12	E:E:H127	E:E:M76	5.25	No	Yes	1	8	9
13	E:E:D77	E:E:P78	9.66	No	No	0	4	5
14	E:E:I79	E:E:K81	4.36	Yes	No	1	7	5
15	E:E:D82	E:E:I79	9.8	No	Yes	1	6	7
16	E:E:I79	E:E:W83	17.62	Yes	Yes	1	7	7
17	E:E:I79	E:E:M88	13.12	Yes	No	0	7	5
18	E:E:E80	E:E:K81	5.4	No	No	0	5	5
19	E:E:D82	E:E:K81	16.59	No	No	1	6	5
20	E:E:I89	E:E:W83	19.97	No	Yes	1	8	7
21	E:E:P92	E:E:W83	8.11	No	Yes	0	6	7
22	E:E:H127	E:E:W83	7.41	No	Yes	1	8	7
23	E:E:C131	E:E:C84	7.28	No	No	0	9	9
24	E:E:D85	E:E:W86	4.47	No	No	0	7	9
25	E:E:A87	E:E:D85	4.63	No	No	0	5	7
26	E:E:D85	E:E:M88	5.54	No	No	0	7	5
27	E:E:I89	E:E:Y93	4.84	No	Yes	1	8	9
28	E:E:F128	E:E:I89	3.77	Yes	No	1	9	8
29	E:E:H124	E:E:Y93	8.71	Yes	Yes	1	9	9
30	E:E:F128	E:E:Y93	4.13	Yes	Yes	1	9	9
31	E:E:Y93	R:R:Q52	13.53	Yes	Yes	1	9	6
32	E:E:Y93	R:R:Y53	6.95	Yes	Yes	1	9	1
33	E:E:S94	R:R:M49	7.67	No	Yes	0	8	4
34	E:E:D98	E:E:T95	5.78	No	No	0	1	2
35	E:E:L100	E:E:L96	4.15	No	No	0	8	8
36	E:E:F111	E:E:R97	11.76	Yes	Yes	1	8	7
37	E:E:R97	R:R:M48	3.72	Yes	No	0	7	6
38	E:E:R97	R:R:M49	6.2	Yes	Yes	1	7	4
39	E:E:R97	R:R:Q52	4.67	Yes	Yes	1	7	6
40	E:E:C99	E:E:D98	6.22	No	No	0	9	1
41	E:E:F111	E:E:L100	7.31	Yes	No	0	8	8
42	E:E:D108	E:E:L109	13.57	No	No	0	3	7
43	E:E:L109	E:E:N113	8.24	No	No	0	7	9
44	E:E:L109	R:R:R126	6.07	No	No	0	7	4
45	E:E:F111	E:E:P112	5.78	Yes	No	1	8	9
46	E:E:E117	E:E:F111	9.33	Yes	Yes	1	8	8
47	E:E:E117	E:E:P112	9.43	Yes	No	1	8	9
48	E:E:P112	L:L:P32	3.9	No	Yes	1	9	0
49	E:E:N113	E:E:P114	11.4	No	No	0	9	5
50	E:E:L115	E:E:N113	6.87	No	No	0	4	9
51	E:E:E117	R:R:Y56	4.49	Yes	Yes	1	8	3
52	E:E:E117	R:R:W76	4.36	Yes	Yes	1	8	8
53	E:E:I120	R:R:Y56	8.46	No	Yes	0	9	3
54	E:E:F121	R:R:Y56	7.22	No	Yes	0	6	3
55	E:E:F121	R:R:M59	7.46	No	No	0	6	5
56	E:E:H124	E:E:T123	6.85	Yes	No	0	9	8
57	E:E:F128	E:E:H124	13.58	Yes	Yes	1	9	9
58	E:E:H124	R:R:Y53	7.62	Yes	Yes	1	9	1
59	E:E:H124	R:R:Y56	21.78	Yes	Yes	1	9	3
60	E:E:H127	E:E:I126	14.58	No	No	0	8	5
61	E:E:F128	R:R:Y53	20.63	Yes	Yes	1	9	1
62	E:E:L133	R:R:D57	6.79	No	No	0	4	4
63	E:E:L133	R:R:Q61	13.31	No	No	0	4	3
64	E:E:P141	E:E:V145	5.3	Yes	No	0	9	7
65	E:E:P141	R:R:Y284	9.74	Yes	No	0	9	2
66	E:E:P142	E:E:V145	10.6	No	No	0	9	7
67	E:E:D144	E:E:E143	3.9	No	No	0	7	7
68	E:E:L146	E:E:M149	4.24	No	No	0	8	9
69	E:E:I150	E:E:L147	5.71	No	No	0	9	7
70	E:E:I151	E:E:L147	9.99	No	No	0	6	7
71	E:E:M149	R:R:I300	4.37	No	No	0	9	8
72	E:E:F159	E:E:L156	6.09	No	No	0	8	9
73	E:E:I157	E:E:P158	5.08	No	No	0	9	9
74	E:E:I157	R:R:F235	5.02	No	Yes	6	9	5
75	E:E:I157	R:R:F269	3.77	No	Yes	6	9	3
76	E:E:L160	R:R:F269	4.87	No	Yes	0	9	3
77	E:E:I161	R:R:I242	7.36	No	Yes	3	9	7
78	E:E:I161	R:R:F315	5.02	No	Yes	3	9	8
79	E:E:V164	R:R:I242	4.61	No	Yes	3	9	7
80	E:E:V164	R:R:Y262	6.31	No	Yes	3	9	7
81	L:L:C1	L:L:C7	7.28	Yes	No	2	0	0
82	L:L:C1	R:R:L298	6.35	Yes	Yes	2	0	6
83	L:L:C1	R:R:H302	5.9	Yes	Yes	2	0	6
84	L:L:S2	R:R:E294	5.75	No	No	0	0	3
85	L:L:N3	R:R:W361	10.17	No	No	0	0	4
86	L:L:N3	R:R:R362	6.03	No	Yes	0	0	4
87	L:L:L4	L:L:T6	4.42	No	Yes	2	0	0
88	L:L:L4	R:R:M306	5.65	No	No	2	0	4
89	L:L:L4	R:R:W361	4.56	No	No	0	0	4
90	L:L:S5	R:R:F356	7.93	No	Yes	0	0	7
91	L:L:S5	R:R:M376	4.6	No	Yes	0	0	7
92	L:L:T6	R:R:Y234	4.99	Yes	No	2	0	7
93	L:L:T6	R:R:H302	10.95	Yes	Yes	2	0	6
94	L:L:T6	R:R:M306	4.52	Yes	No	2	0	4
95	L:L:T6	R:R:F356	3.89	Yes	Yes	2	0	7
96	L:L:C7	R:R:H302	8.85	No	Yes	2	0	6
97	L:L:V8	R:R:H377	8.3	No	Yes	0	0	7
98	L:L:L9	R:R:I198	7.14	Yes	Yes	2	0	7
99	L:L:L9	R:R:L202	4.15	Yes	No	0	0	7
100	L:L:L9	R:R:H226	5.14	Yes	Yes	2	0	6
101	L:L:L9	R:R:H381	6.43	Yes	Yes	0	0	9
102	L:L:E15	L:L:K11	8.1	No	No	0	0	0
103	L:L:L12	R:R:H377	6.43	No	Yes	0	0	7
104	L:L:S13	R:R:H201	5.58	No	Yes	10	0	6
105	L:L:S13	R:R:V206	6.46	No	No	10	0	3
106	L:L:K18	L:L:Q14	16.27	No	No	0	0	0
107	L:L:Q14	R:R:V293	4.3	No	No	0	0	6
108	L:L:Q14	R:R:E294	11.47	No	No	0	0	3
109	L:L:E15	L:L:K18	4.05	No	No	0	0	0
110	L:L:L16	R:R:Y146	7.03	No	Yes	0	0	2
111	L:L:L16	R:R:Y149	8.21	No	Yes	0	0	5
112	L:L:H17	L:L:T21	9.58	Yes	Yes	1	0	0
113	L:L:H17	L:L:Y22	7.62	Yes	Yes	1	0	0
114	L:L:H17	R:R:V212	6.92	Yes	No	0	0	3
115	L:L:H17	R:R:L291	9	Yes	No	0	0	6
116	L:L:K18	R:R:P100	5.02	No	Yes	0	0	4
117	L:L:L19	R:R:T138	8.84	No	No	0	0	2
118	L:L:L19	R:R:L142	4.15	No	No	0	0	2
119	L:L:Q20	R:R:Y146	7.89	No	Yes	0	0	2
120	L:L:T21	L:L:Y22	4.99	Yes	Yes	1	0	0
121	L:L:T21	R:R:G209	5.46	Yes	No	1	0	3
122	L:L:T21	R:R:R213	6.47	Yes	No	1	0	2
123	L:L:Y22	R:R:P38	11.13	Yes	No	1	0	5
124	L:L:Y22	R:R:Y41	4.96	Yes	Yes	1	0	3
125	L:L:Y22	R:R:P100	6.95	Yes	Yes	1	0	4
126	L:L:R24	R:R:N135	8.44	No	Yes	0	0	3
127	L:L:T25	R:R:F99	18.16	No	Yes	1	0	5
128	L:L:T25	R:R:D101	8.67	No	No	1	0	4
129	L:L:T25	R:R:F102	6.49	No	Yes	1	0	4
130	L:L:N26	L:L:T31	4.39	No	Yes	0	0	0
131	L:L:T27	R:R:N135	8.77	No	Yes	0	0	3
132	L:L:S29	R:R:E123	5.75	No	No	0	0	4
133	L:L:?33	L:L:P32	4.06	Yes	Yes	1	0	0
134	L:L:P32	R:R:D77	4.83	Yes	Yes	1	0	9
135	L:L:P32	R:R:W79	22.97	Yes	Yes	1	0	6
136	L:L:?33	R:R:D77	10.08	Yes	Yes	1	0	9
137	L:L:?33	R:R:W128	8.46	Yes	Yes	0	0	5
138	L:L:?33	R:R:S129	7.43	Yes	Yes	1	0	7
139	R:R:K37	R:R:V42	4.55	No	No	0	4	1
140	R:R:P38	R:R:Y41	8.34	No	Yes	1	5	3
141	R:R:F39	R:R:V43	6.55	No	No	5	4	2
142	R:R:F285	R:R:F39	7.5	Yes	No	5	6	4
143	R:R:D287	R:R:F39	4.78	Yes	No	5	3	4
144	R:R:L40	R:R:P100	6.57	No	Yes	0	5	4
145	R:R:F99	R:R:Y41	4.13	Yes	Yes	1	5	3
146	R:R:P100	R:R:Y41	9.74	Yes	Yes	1	4	3
147	R:R:R45	R:R:V42	3.92	No	No	0	7	1
148	R:R:K46	R:R:V42	4.55	No	No	0	4	1
149	R:R:K46	R:R:V43	4.55	No	No	0	4	2
150	R:R:F285	R:R:V43	6.55	Yes	No	5	6	2
151	R:R:M49	R:R:R45	3.72	Yes	No	0	4	7
152	R:R:M48	R:R:W79	5.82	No	Yes	0	6	6
153	R:R:M48	R:R:Y98	13.17	No	Yes	0	6	4
154	R:R:M49	R:R:Q52	6.8	Yes	Yes	1	4	6
155	R:R:D50	R:R:K54	6.91	No	No	0	2	4
156	R:R:Q52	R:R:W76	13.14	Yes	Yes	1	6	8
157	R:R:D57	R:R:Y53	21.84	No	Yes	0	4	1
158	R:R:C55	R:R:C81	7.28	No	No	0	9	9
159	R:R:W76	R:R:Y56	12.54	Yes	Yes	1	8	3
160	R:R:L62	R:R:R58	6.07	No	No	0	3	3
161	R:R:M59	R:R:R74	12.41	No	Yes	0	5	4
162	R:R:L62	R:R:R74	10.93	No	Yes	0	3	4
163	R:R:P63	R:R:Y65	11.13	No	No	0	1	3
164	R:R:D84	R:R:Y65	12.64	No	No	0	4	3
165	R:R:G69	R:R:P70	4.06	No	No	0	1	1
166	R:R:D84	R:R:Y71	5.75	No	No	0	4	3
167	R:R:C72	R:R:T85	5.07	No	Yes	1	9	7
168	R:R:C112	R:R:C72	7.28	No	No	0	9	9
169	R:R:C72	R:R:W118	18.28	No	Yes	1	9	9
170	R:R:D84	R:R:R74	9.53	No	Yes	0	4	4
171	R:R:T75	R:R:W118	8.49	No	Yes	0	5	9
172	R:R:G78	R:R:W76	7.04	No	Yes	0	5	8
173	R:R:C81	R:R:W76	3.92	No	Yes	0	9	8
174	R:R:D77	R:R:W82	6.7	Yes	Yes	1	9	9
175	R:R:D77	R:R:S129	7.36	Yes	Yes	1	9	7
176	R:R:D77	R:R:Y131	8.05	Yes	Yes	1	9	5
177	R:R:F99	R:R:W79	15.03	Yes	Yes	1	5	6
178	R:R:F102	R:R:W79	5.01	Yes	Yes	1	4	6
179	R:R:W79	R:R:Y131	13.5	Yes	Yes	1	6	5
180	R:R:L80	R:R:Q93	15.97	No	No	0	5	6
181	R:R:L80	R:R:P96	8.21	No	Yes	1	5	9
182	R:R:L80	R:R:Y131	7.03	No	Yes	1	5	5
183	R:R:Q93	R:R:W82	9.86	No	Yes	0	6	9
184	R:R:K110	R:R:W82	20.89	Yes	Yes	1	8	9
185	R:R:W118	R:R:W82	3.75	Yes	Yes	1	9	9
186	R:R:S129	R:R:W82	7.41	Yes	Yes	1	7	9
187	R:R:S91	R:R:T85	6.4	No	Yes	0	5	7
188	R:R:T85	R:R:W118	9.7	Yes	Yes	1	7	9
189	R:R:P86	R:R:V89	10.6	No	No	0	2	5
190	R:R:G88	R:R:Y111	4.35	No	Yes	4	8	4
191	R:R:E114	R:R:G88	4.91	Yes	No	4	2	8
192	R:R:L90	R:R:Y92	7.03	No	No	4	4	4
193	R:R:L90	R:R:T109	8.84	No	No	4	4	5
194	R:R:L90	R:R:Y111	4.69	No	Yes	4	4	4
195	R:R:T109	R:R:Y92	8.74	No	No	4	5	4
196	R:R:C134	R:R:C95	7.28	No	No	0	9	9
197	R:R:P96	R:R:Y98	12.52	Yes	Yes	0	9	4
198	R:R:F102	R:R:P96	4.33	Yes	Yes	1	4	9
199	R:R:P96	R:R:Y131	4.17	Yes	Yes	1	9	5
200	R:R:F102	R:R:F99	12.86	Yes	Yes	1	4	5
201	R:R:D101	R:R:F102	9.55	No	Yes	1	4	4
202	R:R:D101	R:R:N135	5.39	No	Yes	1	4	3
203	R:R:C134	R:R:F102	13.97	No	Yes	0	9	4
204	R:R:F102	R:R:N135	7.25	Yes	Yes	1	4	3
205	R:R:D103	R:R:P104	11.27	No	No	0	3	3
206	R:R:D103	R:R:S105	8.83	No	No	0	3	1
207	R:R:E106	R:R:M133	8.12	Yes	No	0	4	5
208	R:R:E106	R:R:F137	13.99	Yes	No	0	4	1
209	R:R:V108	R:R:Y131	11.36	No	Yes	0	7	5
210	R:R:K110	R:R:W118	19.73	Yes	Yes	1	8	9
211	R:R:K110	R:R:S129	13.77	Yes	Yes	1	8	7
212	R:R:E114	R:R:Y111	8.98	Yes	Yes	4	2	4
213	R:R:F119	R:R:Y111	7.22	No	Yes	0	4	4
214	R:R:D113	R:R:K115	5.53	No	No	0	5	5
215	R:R:K120	R:R:N125	6.99	No	No	0	1	7
216	R:R:H121	R:R:P122	7.63	No	No	0	4	5
217	R:R:E123	R:R:H121	6.15	No	No	0	4	4
218	R:R:H121	R:R:W128	20.1	No	Yes	0	4	5
219	R:R:N124	R:R:R126	19.28	No	No	0	5	4
220	R:R:N130	R:R:W128	11.3	No	Yes	0	8	5
221	R:R:S129	R:R:Y131	3.82	Yes	Yes	1	7	5
222	R:R:N130	R:R:T132	4.39	No	No	0	8	6
223	R:R:E140	R:R:F137	12.83	No	No	0	2	1
224	R:R:L142	R:R:Y146	5.86	No	Yes	0	2	2
225	R:R:Y146	R:R:Y150	3.97	Yes	No	0	2	4
226	R:R:V147	R:R:Y374	7.57	No	No	0	4	6
227	R:R:D373	R:R:L148	5.43	No	No	0	5	5
228	R:R:L148	R:R:Y374	7.03	No	No	0	5	6
229	R:R:H377	R:R:L148	11.57	Yes	No	0	7	5
230	R:R:Y149	R:R:Y150	6.95	Yes	No	0	5	4
231	R:R:I153	R:R:Y149	7.25	No	Yes	0	7	5
232	R:R:L202	R:R:Y149	10.55	No	Yes	0	7	5
233	R:R:V203	R:R:Y149	3.79	No	Yes	0	3	5
234	R:R:L151	R:R:S378	6.01	No	No	0	5	5
235	R:R:A152	R:R:H381	7.32	No	Yes	0	7	9
236	R:R:F382	R:R:G155	9.03	No	No	0	7	8
237	R:R:H156	R:R:S195	11.16	Yes	No	0	7	7
238	R:R:H156	R:R:I198	11.93	Yes	Yes	0	7	7
239	R:R:H156	R:R:H381	9.55	Yes	Yes	0	7	9
240	R:R:I160	R:R:I192	4.42	Yes	Yes	7	5	7
241	R:R:I160	R:R:S195	6.19	Yes	No	0	5	7
242	R:R:F161	R:R:I165	5.02	No	No	0	4	5
243	R:R:F385	R:R:T162	10.38	Yes	No	0	5	6
244	R:R:F393	R:R:T162	3.89	No	No	0	8	6
245	R:R:F188	R:R:L163	6.09	Yes	No	0	8	8
246	R:R:I192	R:R:L163	5.71	Yes	No	0	7	8
247	R:R:F188	R:R:S166	5.28	Yes	No	0	8	9
248	R:R:C392	R:R:S166	6.89	No	No	0	9	9
249	R:R:K185	R:R:L167	4.23	Yes	No	0	6	6
250	R:R:F170	R:R:V181	14.42	Yes	Yes	11	8	9
251	R:R:F170	R:R:K185	4.96	Yes	Yes	11	8	6
252	R:R:F170	R:R:F188	6.43	Yes	Yes	0	8	8
253	R:R:C392	R:R:F170	4.19	No	Yes	0	9	8
254	R:R:F170	R:R:V398	3.93	Yes	No	0	8	9
255	R:R:F172	R:R:F173	9.65	No	Yes	0	2	7
256	R:R:F173	R:R:T401	3.89	Yes	No	0	7	7
257	R:R:F173	R:R:V402	3.93	Yes	No	0	7	5
258	R:R:L176	R:R:V398	7.45	No	No	0	9	9
259	R:R:L176	R:R:T401	11.79	No	No	0	9	7
260	R:R:C178	R:R:R180	5.57	No	No	0	8	9
261	R:R:Q179	R:R:Y243	14.65	No	Yes	3	7	8
262	R:R:Q179	R:R:Q257	7.68	No	Yes	3	7	5
263	R:R:L259	R:R:Q179	11.98	No	No	0	5	7
264	R:R:R180	R:R:V181	3.92	No	Yes	0	9	9
265	R:R:H184	R:R:R180	6.77	Yes	No	0	9	9
266	R:R:K185	R:R:V181	4.55	Yes	Yes	11	6	9
267	R:R:K185	R:R:T182	4.5	Yes	No	0	6	5
268	R:R:L183	R:R:W236	4.56	Yes	Yes	3	8	9
269	R:R:E240	R:R:L183	5.3	Yes	Yes	3	9	8
270	R:R:L183	R:R:Y243	5.86	Yes	Yes	3	8	8
271	R:R:L183	R:R:L259	4.15	Yes	No	0	8	5
272	R:R:L183	R:R:Y262	5.86	Yes	Yes	3	8	7
273	R:R:E240	R:R:H184	8.62	Yes	Yes	3	9	9
274	R:R:H184	R:R:L351	5.14	Yes	Yes	3	9	9
275	R:R:H184	R:R:Y391	4.36	Yes	Yes	3	9	8
276	R:R:N186	R:R:W236	11.3	No	Yes	3	9	9
277	R:R:N186	R:R:Y263	10.47	No	No	3	9	5
278	R:R:N186	R:R:W267	6.78	No	No	3	9	9
279	R:R:M187	R:R:T190	4.52	No	No	0	8	9
280	R:R:M187	R:R:Y191	8.38	No	Yes	0	8	8
281	R:R:E240	R:R:M187	8.12	Yes	No	0	9	8
282	R:R:F188	R:R:V387	3.93	Yes	No	0	8	9
283	R:R:L189	R:R:L193	5.54	No	No	0	3	6
284	R:R:N233	R:R:T190	5.85	Yes	No	0	9	9
285	R:R:T190	R:R:W236	9.7	No	Yes	0	9	9
286	R:R:N233	R:R:Y191	18.61	Yes	Yes	2	9	8
287	R:R:M237	R:R:Y191	5.99	No	Yes	2	9	8
288	R:R:Q383	R:R:Y191	14.65	Yes	Yes	2	9	8
289	R:R:G384	R:R:Y191	7.24	No	Yes	0	9	8
290	R:R:V387	R:R:Y191	10.09	No	Yes	0	9	8
291	R:R:L193	R:R:M229	7.07	No	No	0	6	4
292	R:R:I198	R:R:N194	8.5	Yes	Yes	0	7	8
293	R:R:M229	R:R:N194	4.21	No	Yes	0	4	8
294	R:R:M230	R:R:N194	8.41	No	Yes	0	6	8
295	R:R:N194	R:R:N233	5.45	Yes	Yes	0	8	9
296	R:R:H226	R:R:I198	5.3	Yes	Yes	2	6	7
297	R:R:H201	R:R:V205	6.92	Yes	No	0	6	7
298	R:R:H201	R:R:V206	6.92	Yes	No	10	6	3
299	R:R:H201	R:R:L291	3.86	Yes	No	0	6	6
300	R:R:E204	R:R:N208	3.94	No	No	0	4	3
301	R:R:L211	R:R:V205	4.47	No	No	0	1	7
302	R:R:L211	R:R:N208	4.12	No	No	0	1	3
303	R:R:G209	R:R:R213	4.5	No	No	1	3	2
304	R:R:L211	R:R:R214	6.07	No	No	0	1	4
305	R:R:C289	R:R:V212	5.12	No	No	0	9	3
306	R:R:D215	R:R:K220	5.53	No	Yes	0	6	7
307	R:R:D215	R:R:N288	13.46	No	No	0	6	4
308	R:R:C219	R:R:P216	3.77	No	No	0	9	4
309	R:R:C219	R:R:C289	7.28	No	No	0	9	9
310	R:R:K220	R:R:N286	6.99	Yes	No	12	7	7
311	R:R:K220	R:R:W290	13.92	Yes	Yes	12	7	9
312	R:R:F225	R:R:I221	3.77	No	No	0	5	4
313	R:R:H223	R:R:Q227	12.36	No	Yes	0	5	7
314	R:R:H223	R:R:W290	11.64	No	Yes	0	5	9
315	R:R:F224	R:R:F225	5.36	Yes	No	0	5	5
316	R:R:F224	R:R:T274	7.78	Yes	No	0	5	6
317	R:R:H226	R:R:Q227	4.95	Yes	Yes	2	6	7
318	R:R:H226	R:R:M230	11.82	Yes	No	2	6	6
319	R:R:M230	R:R:Q227	4.08	No	Yes	2	6	7
320	R:R:L298	R:R:Q227	3.99	Yes	Yes	2	6	7
321	R:R:I301	R:R:Q227	9.61	Yes	Yes	2	7	7
322	R:R:H302	R:R:Q227	6.18	Yes	Yes	2	6	7
323	R:R:C232	R:R:Y228	9.41	No	No	0	8	8
324	R:R:T274	R:R:Y228	4.99	No	No	0	6	8
325	R:R:C232	R:R:W267	6.53	No	No	0	8	9
326	R:R:C232	R:R:P270	9.41	No	Yes	0	8	9
327	R:R:M237	R:R:N233	4.21	No	Yes	2	9	9
328	R:R:V305	R:R:Y234	10.09	No	No	0	7	7
329	R:R:F356	R:R:Y234	8.25	Yes	No	2	7	7
330	R:R:F235	R:R:F269	8.57	Yes	Yes	6	5	3
331	R:R:F235	R:R:P270	5.78	Yes	Yes	6	5	9
332	R:R:F235	R:R:V305	5.24	Yes	No	0	5	7
333	R:R:A308	R:R:F235	4.16	No	Yes	0	7	5
334	R:R:C239	R:R:W236	7.84	No	Yes	0	7	9
335	R:R:W236	R:R:Y263	3.86	Yes	No	3	9	5
336	R:R:G266	R:R:W236	8.44	No	Yes	0	9	9
337	R:R:W236	R:R:W267	14.99	Yes	No	3	9	9
338	R:R:M237	R:R:Q383	8.16	No	Yes	2	9	9
339	R:R:I242	R:R:L238	7.14	Yes	Yes	0	7	8
340	R:R:L238	R:R:L265	5.54	Yes	No	0	8	7
341	R:R:A308	R:R:L238	4.73	No	Yes	0	7	8
342	R:R:L238	R:R:N312	8.24	Yes	No	0	8	9
343	R:R:C239	R:R:L265	4.76	No	No	0	7	7
344	R:R:E240	R:R:L351	6.63	Yes	Yes	3	9	9
345	R:R:I242	R:R:Y262	6.04	Yes	Yes	3	7	7
346	R:R:F315	R:R:I242	3.77	Yes	Yes	3	8	7
347	R:R:L247	R:R:Y243	12.89	No	Yes	0	8	8
348	R:R:Q257	R:R:Y243	10.15	Yes	Yes	3	5	8
349	R:R:Y243	R:R:Y262	4.96	Yes	Yes	3	8	7
350	R:R:I319	R:R:L244	8.56	No	No	0	9	9
351	R:R:L244	R:R:L348	4.15	No	No	0	9	9
352	R:R:H245	R:R:V249	17.99	Yes	No	0	8	6
353	R:R:H245	R:R:V250	4.15	Yes	No	0	8	5
354	R:R:F315	R:R:H245	23.76	Yes	Yes	0	8	8
355	R:R:H245	R:R:N318	8.93	Yes	No	0	8	8
356	R:R:H245	R:R:I319	3.98	Yes	No	0	8	9
357	R:R:Q257	R:R:T246	9.92	Yes	No	0	5	7
358	R:R:I248	R:R:I319	7.36	No	No	0	7	9
359	R:R:E255	R:R:K256	5.4	No	No	0	6	5
360	R:R:Q257	R:R:Y262	9.02	Yes	Yes	3	5	7
361	R:R:R258	R:R:R260	10.66	No	No	13	5	3
362	R:R:R258	R:R:W261	6	No	No	13	5	2
363	R:R:R260	R:R:W261	20.99	No	No	13	3	2
364	R:R:F269	R:R:P270	4.33	Yes	Yes	6	3	9
365	R:R:P273	R:R:V272	5.3	No	No	0	6	4
366	R:R:I301	R:R:T274	4.56	Yes	No	0	7	6
367	R:R:I276	R:R:I300	4.42	No	No	0	5	8
368	R:R:H277	R:R:R281	10.16	No	Yes	0	7	7
369	R:R:H277	R:R:L298	10.29	No	Yes	0	7	6
370	R:R:H277	R:R:I301	9.28	No	Yes	0	7	7
371	R:R:L297	R:R:T280	4.42	No	No	0	4	4
372	R:R:D287	R:R:R281	10.72	Yes	Yes	0	3	7
373	R:R:R281	R:R:W290	20.99	Yes	Yes	0	7	9
374	R:R:R281	R:R:T295	5.17	Yes	No	0	7	4
375	R:R:V283	R:R:Y284	12.62	No	No	0	3	2
376	R:R:D287	R:R:F285	7.17	Yes	Yes	5	3	6
377	R:R:F285	R:R:S292	3.96	Yes	No	5	6	4
378	R:R:F285	R:R:T295	11.67	Yes	No	0	6	4
379	R:R:N286	R:R:W290	5.65	No	Yes	12	7	9
380	R:R:D287	R:R:S292	7.36	Yes	No	5	3	4
381	R:R:C289	R:R:L291	4.76	No	No	0	9	6
382	R:R:L297	R:R:T295	5.9	No	No	0	4	4
383	R:R:H296	R:R:Y299	6.53	No	No	0	2	7
384	R:R:H302	R:R:L298	5.14	Yes	Yes	2	6	6
385	R:R:H302	R:R:I301	9.28	Yes	Yes	2	6	7
386	R:R:G303	R:R:P304	4.06	No	No	0	4	9
387	R:R:F356	R:R:L309	4.87	Yes	No	0	7	7
388	R:R:F314	R:R:V310	3.93	No	No	0	5	4
389	R:R:F315	R:R:V311	6.55	Yes	No	0	8	6
390	R:R:L352	R:R:N312	6.87	Yes	No	0	9	9
391	R:R:F313	R:R:L317	8.53	Yes	No	0	6	5
392	R:R:F313	R:R:V357	7.87	Yes	No	0	6	7
393	R:R:L316	R:R:T345	4.42	No	No	0	9	9
394	R:R:L316	R:R:L348	4.15	No	No	0	9	9
395	R:R:I354	R:R:L316	7.14	No	No	0	6	9
396	R:R:N318	R:R:R321	7.23	No	No	0	8	8
397	R:R:T345	R:R:V320	6.35	No	No	0	9	7
398	R:R:E332	R:R:M327	8.12	No	Yes	0	5	7
399	R:R:M327	R:R:M337	10.11	Yes	No	0	7	7
400	R:R:K340	R:R:M327	4.32	No	Yes	0	8	7
401	R:R:M337	R:R:R328	3.72	No	No	0	7	6
402	R:R:E332	R:R:H336	8.62	No	No	0	5	6
403	R:R:E334	R:R:M337	5.41	No	No	0	6	7
404	R:R:E334	R:R:Y338	4.49	No	No	0	6	7
405	R:R:H336	R:R:L339	5.14	No	No	0	6	6
406	R:R:K340	R:R:K343	5.75	No	No	0	8	8
407	R:R:I347	R:R:K343	4.36	No	No	0	8	8
408	R:R:I347	R:R:I390	5.89	No	No	0	8	8
409	R:R:L348	R:R:Y391	4.69	No	Yes	0	9	8
410	R:R:I354	R:R:V349	9.22	No	No	0	6	8
411	R:R:Q355	R:R:V349	4.3	Yes	No	0	8	8
412	R:R:F386	R:R:P350	5.78	No	No	0	5	9
413	R:R:L351	R:R:L352	4.15	Yes	Yes	0	9	9
414	R:R:L351	R:R:Y391	19.93	Yes	Yes	3	9	8
415	R:R:I354	R:R:L352	4.28	No	Yes	0	6	9
416	R:R:G353	R:R:Q355	4.93	No	Yes	0	9	8
417	R:R:F356	R:R:Q355	12.88	Yes	Yes	2	7	8
418	R:R:L379	R:R:Q355	5.32	No	Yes	0	5	8
419	R:R:Q355	R:R:Q383	11.52	Yes	Yes	2	8	9
420	R:R:F356	R:R:I380	11.3	Yes	No	0	7	6
421	R:R:F356	R:R:Q383	4.68	Yes	Yes	2	7	9
422	R:R:F359	R:R:V358	7.87	Yes	No	0	6	5
423	R:R:F359	R:R:Y372	4.13	Yes	Yes	9	6	7
424	R:R:F359	R:R:M376	4.98	Yes	Yes	9	6	7
425	R:R:G369	R:R:R362	7.51	No	Yes	0	4	4
426	R:R:R362	R:R:Y372	7.2	Yes	Yes	0	4	7
427	R:R:D373	R:R:R362	11.91	No	Yes	0	5	4
428	R:R:G369	R:R:P363	4.06	No	No	0	4	7
429	R:R:P363	R:R:Y372	9.74	No	Yes	0	7	7
430	R:R:L368	R:R:N365	9.61	No	No	0	3	4
431	R:R:K370	R:R:Y374	13.14	No	No	0	4	6
432	R:R:M376	R:R:Y372	11.97	Yes	Yes	9	7	7
433	R:R:I380	R:R:M376	4.37	No	Yes	0	6	7
434	R:R:H377	R:R:H381	9.55	Yes	Yes	0	7	9
435	R:R:F382	R:R:F386	4.29	No	No	0	7	5
436	R:R:F385	R:R:F386	4.29	Yes	No	0	5	5
437	R:R:F385	R:R:T389	7.78	Yes	No	0	5	5
438	R:R:V387	R:R:Y391	3.79	No	Yes	0	9	8
439	R:R:F393	R:R:T389	5.19	No	No	0	8	5
440	R:R:I390	R:R:Y391	7.25	No	Yes	0	8	8
441	R:R:C392	R:R:F393	4.19	No	No	0	9	8
442	R:R:E397	R:R:N395	5.26	No	No	0	9	9
443	R:R:N395	R:R:V398	5.91	No	No	0	9	9
444	R:R:G384	R:R:S159	3.71	No	No	0	9	9
445	R:R:G177	R:R:V181	3.68	No	Yes	0	7	9
446	R:R:F382	R:R:L151	3.65	No	No	0	7	5
447	R:R:F385	R:R:L158	3.65	Yes	No	0	5	4
448	R:R:D83	R:R:R74	3.57	No	Yes	0	5	4
449	R:R:P207	R:R:V206	3.53	No	No	0	3	3
450	R:R:L271	R:R:Y228	3.52	No	No	0	4	8
451	R:R:F173	R:R:Q405	3.51	Yes	No	0	7	4
452	R:R:P86	R:R:T85	3.5	No	Yes	0	2	7
453	R:R:P139	R:R:T138	3.5	No	No	0	3	2
454	R:R:N73	R:R:Y71	3.49	No	No	0	4	3
455	R:R:A388	R:R:S166	3.42	No	No	0	8	9
456	R:R:G268	R:R:L271	3.42	No	No	0	6	4
457	E:E:I150	R:R:P304	3.39	No	No	0	9	9
458	E:E:M149	E:E:P141	3.35	No	Yes	0	9	9
459	R:R:G69	R:R:Q66	3.29	No	No	0	1	1
460	E:E:P141	R:R:L297	3.28	Yes	No	0	9	4
461	R:R:L368	R:R:P363	3.28	No	No	0	3	7
462	E:E:C155	E:E:I151	3.27	No	No	0	7	6
463	E:E:C155	E:E:I154	3.27	No	No	0	7	9
464	E:E:I154	R:R:A307	3.25	No	No	0	9	3
465	E:E:D140	E:E:P141	3.22	No	Yes	0	9	9
466	R:R:S175	R:R:T401	3.2	No	No	0	8	7
467	E:E:A116	E:E:L100	3.15	No	No	0	9	8
468	R:R:A344	R:R:L323	3.15	No	No	0	9	9
469	R:R:E68	R:R:P86	3.14	No	No	0	1	2
470	E:E:I119	E:E:V65	3.07	No	No	0	5	5
471	R:R:I248	R:R:V322	3.07	No	No	0	7	8
472	R:R:C95	R:R:E106	3.04	No	Yes	0	9	4
473	R:R:K326	R:R:V322	3.04	No	No	0	9	8
474	R:R:M346	R:R:T345	3.01	No	No	0	8	9
475	R:R:K110	R:R:T127	3	Yes	No	0	8	4
476	R:R:L271	R:R:V272	2.98	No	No	0	4	4
477	R:R:N130	R:R:T109	2.92	No	No	0	8	5
478	R:R:D113	R:R:V117	2.92	No	No	0	5	5
479	R:R:I160	R:R:M196	2.92	Yes	No	7	5	4
480	R:R:I192	R:R:M196	2.92	Yes	No	7	7	4
481	R:R:I197	R:R:M229	2.92	No	No	0	5	4
482	R:R:I371	R:R:M367	2.92	No	No	0	5	4
483	E:E:W69	E:E:Y72	2.89	Yes	No	0	6	9
484	E:E:P92	E:E:R91	2.88	No	No	0	6	6
485	R:R:E106	R:R:S105	2.87	Yes	No	0	4	1
486	E:E:I150	E:E:L146	2.85	No	No	0	9	8
487	R:R:I200	R:R:L222	2.85	No	No	0	6	6
488	R:R:L323	R:R:M327	2.83	No	Yes	0	9	7
489	L:L:L19	R:R:K141	2.82	No	No	0	0	3
490	E:E:C68	E:E:F103	2.79	No	Yes	8	9	1
491	E:E:C99	E:E:F103	2.79	No	Yes	8	9	1
492	E:E:C155	E:E:F159	2.79	No	No	0	7	8
493	R:R:A136	R:R:F137	2.77	No	No	0	2	1
494	R:R:A278	R:R:F224	2.77	No	Yes	0	6	5
495	R:R:E140	R:R:K366	2.7	No	No	0	2	3
496	R:R:E329	R:R:K326	2.7	No	No	0	6	9
497	L:L:C1	R:R:Y299	2.69	Yes	No	0	0	7
498	R:R:A51	R:R:Y98	2.67	No	Yes	0	8	4
499	R:R:H156	R:R:I199	2.65	Yes	No	0	7	7
500	R:R:E255	R:R:L247	2.65	No	No	0	6	8
501	L:L:S29	R:R:R126	2.64	No	No	0	0	4
502	R:R:F313	R:R:V358	2.62	Yes	No	0	6	5
503	R:R:R328	R:R:V324	2.62	No	No	0	6	5
504	R:R:F359	R:R:V375	2.62	Yes	No	0	6	4
505	R:R:F161	R:R:T162	2.59	No	No	0	4	6
506	R:R:F224	R:R:T275	2.59	Yes	No	0	5	3
507	R:R:R404	R:R:T400	2.59	No	No	0	7	4
508	R:R:F173	R:R:I169	2.51	Yes	No	0	7	8
509	R:R:F94	R:R:K107	2.48	No	No	0	3	3
510	E:E:F103	E:E:L106	2.44	Yes	No	0	1	1
511	L:L:T31	R:R:W79	2.43	Yes	Yes	0	0	6
512	L:L:T31	R:R:W128	2.43	Yes	Yes	0	0	5
513	E:E:D108	E:E:F107	2.39	No	No	0	3	5
514	R:R:K47	R:R:Y98	2.39	No	Yes	0	4	4
515	R:R:K107	R:R:Y92	2.39	No	No	0	3	4
516	E:E:I119	E:E:W69	2.35	No	Yes	0	5	6
517	R:R:Q405	R:R:R404	2.34	No	No	0	4	7
518	E:E:E101	E:E:F111	2.33	No	Yes	0	8	8
519	R:R:D97	R:R:Y98	2.3	No	Yes	0	2	4
520	R:R:L264	R:R:W261	2.28	No	No	0	3	2
521	E:E:F103	E:E:H102	2.26	Yes	No	0	1	1
522	R:R:Q66	R:R:Y71	2.25	No	No	0	1	3
523	R:R:F313	R:R:F314	2.14	Yes	No	0	6	5
524	E:E:G110	L:L:G30	2.11	No	No	0	5	0
525	E:E:A104	E:E:G110	1.95	No	No	0	9	5
526	E:E:P153	R:R:P304	1.95	No	No	0	9	9
527	E:E:A152	E:E:P153	1.87	No	No	0	7	9
528	R:R:A231	R:R:P270	1.87	No	Yes	0	5	9
529	L:L:G10	L:L:S13	1.86	No	No	0	0	0
530	L:L:G30	L:L:S29	1.86	No	No	0	0	0
531	R:R:G116	R:R:V117	1.84	No	No	0	9	5
532	R:R:G168	R:R:V171	1.84	No	No	0	1	4
533	L:L:G28	L:L:T31	1.82	No	Yes	0	0	0
534	R:R:P216	R:R:S218	1.78	No	No	0	4	3
535	R:R:G241	R:R:L244	1.71	No	No	0	8	9
536	R:R:G241	R:R:L352	1.71	No	Yes	0	8	9
537	R:R:G268	R:R:L264	1.71	No	No	0	6	3
538	R:R:A333	R:R:S335	1.71	No	No	0	5	6
539	R:R:A251	R:R:V250	1.7	No	No	0	6	5
540	R:R:A341	R:R:V324	1.7	No	No	0	9	5
541	R:R:A251	R:R:T254	1.68	No	No	0	6	6
542	R:R:M306	R:R:P360	1.68	No	No	0	4	5
543	R:R:G67	R:R:Q66	1.64	No	No	0	2	1
544	E:E:V165	R:R:T246	1.59	No	No	0	9	7
545	R:R:T325	R:R:V322	1.59	No	No	0	7	8
546	L:L:L12	R:R:A145	1.58	No	No	0	0	4
547	L:L:L16	R:R:A145	1.58	No	No	0	0	4
548	R:R:A282	R:R:N286	1.56	No	No	0	3	7
549	R:R:I153	R:R:S157	1.55	No	No	0	7	7
550	R:R:I160	R:R:V164	1.54	Yes	No	7	5	4
551	R:R:I192	R:R:V164	1.54	Yes	No	7	7	4
552	R:R:I371	R:R:V375	1.54	No	No	0	5	4
553	E:E:I161	E:E:T162	1.52	No	No	0	9	8
554	R:R:K220	R:R:V217	1.52	Yes	No	0	7	3
555	R:R:K403	R:R:V402	1.52	No	No	0	6	5
556	R:R:A87	R:R:E114	1.51	No	Yes	0	4	2
557	E:E:L133	E:E:V134	1.49	No	No	0	4	5
558	R:R:L222	R:R:V205	1.49	No	No	0	6	7
559	E:E:C68	E:E:H71	1.47	No	No	0	9	1
560	E:E:N60	E:E:T63	1.46	No	No	0	3	3
561	R:R:N396	R:R:T400	1.46	No	No	0	6	4
562	R:R:G44	R:R:Y98	1.45	No	Yes	0	4	4
563	R:R:K370	R:R:N144	1.4	No	No	0	4	4
564	L:L:P23	L:L:Y22	1.39	No	Yes	0	0	0
565	R:R:H336	R:R:S335	1.39	No	No	0	6	6
566	E:E:D77	E:E:K73	1.38	No	No	0	4	5
567	E:E:L106	E:E:N60	1.37	No	No	0	1	3
568	E:E:I126	E:E:Q125	1.37	No	No	0	5	5
569	R:R:K403	R:R:Q399	1.36	No	No	0	6	7
570	E:E:N70	E:E:Q66	1.32	No	No	0	2	4
571	E:E:D74	E:E:Q75	1.31	No	No	0	1	3
572	R:R:E210	R:R:N208	1.31	No	No	0	3	3
573	R:R:D113	R:R:E114	1.3	No	Yes	0	5	2
574	E:E:I119	E:E:R118	1.25	No	No	0	5	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	E:E:W69	4.075	4	0	6
2	E:E:M76	10.555	4	1	9
3	E:E:I79	11.225	4	1	7
4	E:E:W83	13.414	5	1	7
5	E:E:Y93	7.632	5	1	9
6	E:E:R97	6.5875	4	1	7
7	E:E:F103	4.19167	6	8	1
8	E:E:F111	7.302	5	1	8
9	E:E:E117	6.9025	4	1	8
10	E:E:H124	11.708	5	1	9
11	E:E:F128	10.5275	4	1	9
12	E:E:P141	4.978	5	0	9
13	L:L:C1	5.555	4	2	0
14	L:L:T6	5.754	5	2	0
15	L:L:L9	5.715	4	2	0
16	L:L:H17	8.28	4	1	0
17	L:L:T21	6.625	4	1	0
18	L:L:Y22	6.17333	6	1	0
19	L:L:T31	2.7675	4	0	0
20	L:L:P32	8.94	4	1	0
21	L:L:?33	7.5075	4	1	0
22	R:R:Y41	6.7925	4	1	3
23	R:R:M49	6.0975	4	1	4
24	R:R:Q52	9.535	4	1	6
25	R:R:Y53	14.26	4	1	1
26	R:R:Y56	10.898	5	1	3
27	R:R:R74	9.11	4	0	4
28	R:R:W76	8.2	5	1	8
29	R:R:D77	7.404	5	1	9
30	R:R:W79	10.7933	6	1	6
31	R:R:W82	9.722	5	1	9
32	R:R:T85	6.1675	4	1	7
33	R:R:P96	7.3075	4	1	9
34	R:R:Y98	5.75	6	0	4
35	R:R:F99	12.545	4	1	5
36	R:R:P100	7.07	4	1	4
37	R:R:F102	8.49429	7	1	4
38	R:R:E106	7.005	4	0	4
39	R:R:K110	14.3475	4	1	8
40	R:R:Y111	6.31	4	4	4
41	R:R:E114	4.175	4	4	2
42	R:R:W118	11.99	5	1	9
43	R:R:W128	10.5725	4	0	5
44	R:R:S129	7.958	5	1	7
45	R:R:Y131	7.98833	6	1	5
46	R:R:N135	7.4625	4	1	3
47	R:R:Y146	6.1875	4	0	2
48	R:R:Y149	7.35	5	0	5
49	R:R:H156	8.8225	4	0	7
50	R:R:I160	3.7675	4	7	5
51	R:R:F170	6.786	5	11	8
52	R:R:F173	4.698	5	0	7
53	R:R:V181	6.6425	4	11	9
54	R:R:L183	5.146	5	3	8
55	R:R:H184	6.2225	4	3	9
56	R:R:K185	4.56	4	11	6
57	R:R:F188	5.4325	4	0	8
58	R:R:Y191	10.8267	6	2	8
59	R:R:I192	3.6475	4	7	7
60	R:R:N194	6.6425	4	0	8
61	R:R:I198	8.2175	4	2	7
62	R:R:H201	5.82	4	10	6
63	R:R:K220	6.99	4	12	7
64	R:R:F224	4.625	4	0	5
65	R:R:H226	6.8025	4	2	6
66	R:R:Q227	6.86167	6	2	7
67	R:R:N233	8.53	4	2	9
68	R:R:F235	5.754	5	6	5
69	R:R:W236	8.67	7	3	9
70	R:R:L238	6.4125	4	0	8
71	R:R:E240	7.1675	4	3	9
72	R:R:I242	5.784	5	3	7
73	R:R:Y243	9.702	5	3	8
74	R:R:H245	11.762	5	0	8
75	R:R:Q257	9.1925	4	3	5
76	R:R:Y262	6.438	5	3	7
77	R:R:F269	5.385	4	6	3
78	R:R:P270	5.3475	4	6	9
79	R:R:R281	11.76	4	0	7
80	R:R:F285	7.37	5	5	6
81	R:R:D287	7.5075	4	5	3
82	R:R:W290	13.05	4	12	9
83	R:R:L298	6.4425	4	2	6
84	R:R:I301	8.1825	4	2	7
85	R:R:H302	7.71667	6	2	6
86	R:R:F313	5.29	4	0	6
87	R:R:F315	9.775	4	3	8
88	R:R:M327	6.345	4	0	7
89	R:R:L351	8.9625	4	3	9
90	R:R:L352	4.2525	4	0	9
91	R:R:Q355	7.79	5	2	8
92	R:R:F356	7.68571	7	2	7
93	R:R:F359	4.9	4	9	6
94	R:R:R362	8.1625	4	0	4
95	R:R:Y372	8.26	4	9	7
96	R:R:M376	6.48	4	9	7
97	R:R:H377	8.9625	4	0	7
98	R:R:H381	8.2125	4	0	9
99	R:R:Q383	9.7525	4	2	9
100	R:R:F385	6.525	4	0	5
101	R:R:Y391	8.004	5	3	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:S29	R:R:E123	10.1255	5.75	No	No	0	0	4
2	R:R:E123	R:R:H121	10.5443	6.15	No	No	0	4	4
3	R:R:H121	R:R:W128	11.381	20.1	No	Yes	0	4	5
4	L:L:T31	R:R:W128	17.9294	2.43	Yes	Yes	0	0	5
5	L:L:T31	R:R:W79	19.1605	2.43	Yes	Yes	0	0	6
6	R:R:M48	R:R:W79	62.7054	5.82	No	Yes	0	6	6
7	E:E:R97	R:R:M48	66.266	3.72	Yes	No	0	7	6
8	E:E:Y93	R:R:Q52	12.4338	13.53	Yes	Yes	1	9	6
9	E:E:R97	R:R:M49	76.9163	6.2	Yes	Yes	1	7	4
10	R:R:M49	R:R:R45	98.5517	3.72	Yes	No	0	4	7
11	R:R:R45	R:R:V42	98.9142	3.92	No	No	0	7	1
12	R:R:K46	R:R:V42	99.6383	4.55	No	No	0	4	1
13	R:R:K46	R:R:V43	100	4.55	No	No	0	4	2
14	R:R:F285	R:R:V43	67.1634	6.55	Yes	No	5	6	2
15	R:R:F285	R:R:T295	34.0792	11.67	Yes	No	0	6	4
16	R:R:F39	R:R:V43	33.1955	6.55	No	No	5	4	2
17	R:R:D287	R:R:F39	33.2934	4.78	Yes	No	5	3	4
18	R:R:D287	R:R:R281	66.7847	10.72	Yes	Yes	0	3	7
19	R:R:H277	R:R:R281	85.1808	10.16	No	Yes	0	7	7
20	R:R:H277	R:R:L298	38.6972	10.29	No	Yes	0	7	6
21	R:R:H302	R:R:L298	20.8389	5.14	Yes	Yes	2	6	6
22	L:L:T6	R:R:H302	41.7961	10.95	Yes	Yes	2	0	6
23	R:R:D287	R:R:F285	33.2964	7.17	Yes	Yes	5	3	6
24	R:R:R281	R:R:T295	36.5101	5.17	Yes	No	0	7	4
25	R:R:H277	R:R:I301	46.494	9.28	No	Yes	0	7	7
26	R:R:H302	R:R:I301	21.0455	9.28	Yes	Yes	2	6	7
27	R:R:F99	R:R:W79	17.6276	15.03	Yes	Yes	1	5	6
28	R:R:F99	R:R:Y41	16.9267	4.13	Yes	Yes	1	5	3
29	L:L:T6	R:R:F356	35.9339	3.89	Yes	Yes	2	0	7
30	R:R:L298	R:R:Q227	17.4346	3.99	Yes	Yes	2	6	7
31	R:R:H226	R:R:Q227	13.9505	4.95	Yes	Yes	2	6	7
32	L:L:L9	R:R:H226	10.863	5.14	Yes	Yes	2	0	6
33	R:R:I301	R:R:Q227	17.6207	9.61	Yes	Yes	2	7	7
34	R:R:R281	R:R:W290	18.1867	20.99	Yes	Yes	0	7	9
35	R:R:H223	R:R:W290	17.7421	11.64	No	Yes	0	5	9
36	R:R:H223	R:R:Q227	17.6812	12.36	No	Yes	0	5	7
37	L:L:Y22	R:R:Y41	12.2755	4.96	Yes	Yes	1	0	3
38	L:L:H17	L:L:Y22	10.1955	7.62	Yes	Yes	1	0	0
39	R:R:D77	R:R:W82	12.3215	6.7	Yes	Yes	1	9	9
40	R:R:W118	R:R:W82	14.8232	3.75	Yes	Yes	1	9	9
41	R:R:T85	R:R:W118	10.3085	9.7	Yes	Yes	1	7	9
42	R:R:W79	R:R:Y131	15.0308	13.5	Yes	Yes	1	6	5
43	R:R:M230	R:R:Q227	38.5205	4.08	No	Yes	2	6	7
44	R:R:M230	R:R:N194	38.2546	8.41	No	Yes	0	6	8
45	R:R:N194	R:R:N233	37.8384	5.45	Yes	Yes	0	8	9
46	R:R:N233	R:R:Y191	34.8528	18.61	Yes	Yes	2	9	8
47	R:R:V387	R:R:Y191	53.7656	10.09	No	Yes	0	9	8
48	R:R:F188	R:R:V387	37.3853	3.93	Yes	No	0	8	9
49	R:R:F188	R:R:S166	12.8775	5.28	Yes	No	0	8	9
50	R:R:C392	R:R:S166	11.7951	6.89	No	No	0	9	9
51	R:R:C392	R:R:F393	22.7008	4.19	No	No	0	9	8
52	R:R:F393	R:R:T162	11.8926	3.89	No	No	0	8	6
53	R:R:F385	R:R:F386	12.9779	4.29	Yes	No	0	5	5
54	R:R:F356	R:R:Q383	24.1388	4.68	Yes	Yes	2	7	9
55	R:R:Q383	R:R:Y191	23.759	14.65	Yes	Yes	2	9	8
56	R:R:F170	R:R:F188	23.5303	6.43	Yes	Yes	0	8	8
57	R:R:C392	R:R:F170	11.9959	4.19	No	Yes	0	9	8
58	R:R:V387	R:R:Y391	16.8829	3.79	No	Yes	0	9	8
59	E:E:F111	E:E:R97	11.2598	11.76	Yes	Yes	1	8	7
60	R:R:M49	R:R:Q52	20.9091	6.8	Yes	Yes	1	4	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
E:E:L109	R:R:R126	6.07	0	No	No	7	4	2	1
E:E:F111	E:E:P112	5.78	1	Yes	No	8	9	2	1
E:E:E117	E:E:F111	9.33	1	Yes	Yes	8	8	2	2
E:E:E117	E:E:P112	9.43	1	Yes	No	8	9	2	1
E:E:P112	L:L:P32	3.9	1	No	Yes	9	0	1	0
L:L:C1	R:R:L298	6.35	2	Yes	Yes	0	6	0	1
L:L:C1	R:R:H302	5.9	2	Yes	Yes	0	6	0	1
L:L:S2	R:R:E294	5.75	0	No	No	0	3	0	1
L:L:N3	R:R:W361	10.17	0	No	No	0	4	0	1
L:L:N3	R:R:R362	6.03	0	No	Yes	0	4	0	1
L:L:L4	R:R:M306	5.65	2	No	No	0	4	0	1
L:L:L4	R:R:W361	4.56	2	No	No	0	4	0	1
L:L:S5	R:R:F356	7.93	0	No	Yes	0	7	0	1
L:L:S5	R:R:M376	4.6	0	No	Yes	0	7	0	1
L:L:T6	R:R:Y234	4.99	2	Yes	No	0	7	0	1
L:L:T6	R:R:H302	10.95	2	Yes	Yes	0	6	0	1
L:L:T6	R:R:M306	4.52	2	Yes	No	0	4	0	1
L:L:T6	R:R:F356	3.89	2	Yes	Yes	0	7	0	1
L:L:C7	R:R:H302	8.85	2	No	Yes	0	6	0	1
L:L:V8	R:R:H377	8.3	0	No	Yes	0	7	0	1
L:L:L9	R:R:I198	7.14	2	Yes	Yes	0	7	0	1
L:L:L9	R:R:L202	4.15	2	Yes	No	0	7	0	1
L:L:L9	R:R:H226	5.14	2	Yes	Yes	0	6	0	1
L:L:L9	R:R:H381	6.43	2	Yes	Yes	0	9	0	1
L:L:L12	R:R:H377	6.43	0	No	Yes	0	7	0	1
L:L:S13	R:R:H201	5.58	10	No	Yes	0	6	0	1
L:L:S13	R:R:V206	6.46	10	No	No	0	3	0	1
L:L:Q14	R:R:V293	4.3	0	No	No	0	6	0	1
L:L:Q14	R:R:E294	11.47	0	No	No	0	3	0	1
L:L:L16	R:R:Y146	7.03	0	No	Yes	0	2	0	1
L:L:L16	R:R:Y149	8.21	0	No	Yes	0	5	0	1
L:L:H17	R:R:V212	6.92	1	Yes	No	0	3	0	1
L:L:H17	R:R:L291	9	1	Yes	No	0	6	0	1
L:L:K18	R:R:P100	5.02	0	No	Yes	0	4	0	1
L:L:L19	R:R:T138	8.84	0	No	No	0	2	0	1
L:L:L19	R:R:L142	4.15	0	No	No	0	2	0	1
L:L:Q20	R:R:Y146	7.89	0	No	Yes	0	2	0	1
L:L:T21	R:R:G209	5.46	1	Yes	No	0	3	0	1
L:L:T21	R:R:R213	6.47	1	Yes	No	0	2	0	1
L:L:Y22	R:R:P38	11.13	1	Yes	No	0	5	0	1
L:L:Y22	R:R:Y41	4.96	1	Yes	Yes	0	3	0	1
L:L:Y22	R:R:P100	6.95	1	Yes	Yes	0	4	0	1
L:L:R24	R:R:N135	8.44	0	No	Yes	0	3	0	1
L:L:T25	R:R:F99	18.16	1	No	Yes	0	5	0	1
L:L:T25	R:R:D101	8.67	1	No	No	0	4	0	1
L:L:T25	R:R:F102	6.49	1	No	Yes	0	4	0	1
L:L:T27	R:R:N135	8.77	0	No	Yes	0	3	0	1
L:L:S29	R:R:E123	5.75	0	No	No	0	4	0	1
L:L:P32	R:R:D77	4.83	1	Yes	Yes	0	9	0	1
L:L:P32	R:R:W79	22.97	1	Yes	Yes	0	6	0	1
L:L:?33	R:R:D77	10.08	1	Yes	Yes	0	9	0	1
L:L:?33	R:R:W128	8.46	1	Yes	Yes	0	5	0	1
L:L:?33	R:R:S129	7.43	1	Yes	Yes	0	7	0	1
R:R:P38	R:R:Y41	8.34	1	No	Yes	5	3	1	1
R:R:L40	R:R:P100	6.57	0	No	Yes	5	4	2	1
R:R:F99	R:R:Y41	4.13	1	Yes	Yes	5	3	1	1
R:R:P100	R:R:Y41	9.74	1	Yes	Yes	4	3	1	1
R:R:M48	R:R:W79	5.82	0	No	Yes	6	6	2	1
R:R:D77	R:R:W82	6.7	1	Yes	Yes	9	9	1	2
R:R:D77	R:R:S129	7.36	1	Yes	Yes	9	7	1	1
R:R:D77	R:R:Y131	8.05	1	Yes	Yes	9	5	1	2
R:R:F99	R:R:W79	15.03	1	Yes	Yes	5	6	1	1
R:R:F102	R:R:W79	5.01	1	Yes	Yes	4	6	1	1
R:R:W79	R:R:Y131	13.5	1	Yes	Yes	6	5	1	2
R:R:K110	R:R:W82	20.89	1	Yes	Yes	8	9	2	2
R:R:S129	R:R:W82	7.41	1	Yes	Yes	7	9	1	2
R:R:F102	R:R:P96	4.33	1	Yes	Yes	4	9	1	2
R:R:P96	R:R:Y131	4.17	1	Yes	Yes	9	5	2	2
R:R:F102	R:R:F99	12.86	1	Yes	Yes	4	5	1	1
R:R:D101	R:R:F102	9.55	1	No	Yes	4	4	1	1
R:R:D101	R:R:N135	5.39	1	No	Yes	4	3	1	1
R:R:C134	R:R:F102	13.97	0	No	Yes	9	4	2	1
R:R:F102	R:R:N135	7.25	1	Yes	Yes	4	3	1	1
R:R:K110	R:R:S129	13.77	1	Yes	Yes	8	7	2	1
R:R:E123	R:R:H121	6.15	0	No	No	4	4	1	2
R:R:H121	R:R:W128	20.1	0	No	Yes	4	5	2	1
R:R:N124	R:R:R126	19.28	0	No	No	5	4	2	1
R:R:N130	R:R:W128	11.3	0	No	Yes	8	5	2	1
R:R:S129	R:R:Y131	3.82	1	Yes	Yes	7	5	1	2
R:R:L142	R:R:Y146	5.86	0	No	Yes	2	2	1	1
R:R:Y146	R:R:Y150	3.97	0	Yes	No	2	4	1	2
R:R:D373	R:R:L148	5.43	0	No	No	5	5	2	2
R:R:H377	R:R:L148	11.57	0	Yes	No	7	5	1	2
R:R:Y149	R:R:Y150	6.95	0	Yes	No	5	4	1	2
R:R:I153	R:R:Y149	7.25	0	No	Yes	7	5	2	1
R:R:L202	R:R:Y149	10.55	0	No	Yes	7	5	1	1
R:R:V203	R:R:Y149	3.79	0	No	Yes	3	5	2	1
R:R:A152	R:R:H381	7.32	0	No	Yes	7	9	2	1
R:R:H156	R:R:I198	11.93	0	Yes	Yes	7	7	2	1
R:R:H156	R:R:H381	9.55	0	Yes	Yes	7	9	2	1
R:R:I198	R:R:N194	8.5	2	Yes	Yes	7	8	1	2
R:R:M230	R:R:N194	8.41	2	No	Yes	6	8	2	2
R:R:H226	R:R:I198	5.3	2	Yes	Yes	6	7	1	1
R:R:H201	R:R:V205	6.92	10	Yes	No	6	7	1	2
R:R:H201	R:R:V206	6.92	10	Yes	No	6	3	1	1
R:R:H201	R:R:L291	3.86	10	Yes	No	6	6	1	1
R:R:G209	R:R:R213	4.5	1	No	No	3	2	1	1
R:R:C289	R:R:V212	5.12	0	No	No	9	3	2	1
R:R:H226	R:R:Q227	4.95	2	Yes	Yes	6	7	1	2
R:R:H226	R:R:M230	11.82	2	Yes	No	6	6	1	2
R:R:M230	R:R:Q227	4.08	2	No	Yes	6	7	2	2
R:R:L298	R:R:Q227	3.99	2	Yes	Yes	6	7	1	2
R:R:I301	R:R:Q227	9.61	2	Yes	Yes	7	7	2	2
R:R:H302	R:R:Q227	6.18	2	Yes	Yes	6	7	1	2
R:R:V305	R:R:Y234	10.09	0	No	No	7	7	2	1
R:R:F356	R:R:Y234	8.25	2	Yes	No	7	7	1	1
R:R:H277	R:R:L298	10.29	0	No	Yes	7	6	2	1
R:R:H277	R:R:I301	9.28	0	No	Yes	7	7	2	2
R:R:C289	R:R:L291	4.76	0	No	No	9	6	2	1
R:R:H296	R:R:Y299	6.53	0	No	No	2	7	2	1
R:R:H302	R:R:L298	5.14	2	Yes	Yes	6	6	1	1
R:R:H302	R:R:I301	9.28	2	Yes	Yes	6	7	1	2
R:R:F356	R:R:L309	4.87	2	Yes	No	7	7	1	2
R:R:F356	R:R:Q355	12.88	2	Yes	Yes	7	8	1	2
R:R:Q355	R:R:Q383	11.52	2	Yes	Yes	8	9	2	2
R:R:F356	R:R:I380	11.3	2	Yes	No	7	6	1	2
R:R:F356	R:R:Q383	4.68	2	Yes	Yes	7	9	1	2
R:R:F359	R:R:Y372	4.13	9	Yes	Yes	6	7	2	2
R:R:F359	R:R:M376	4.98	9	Yes	Yes	6	7	2	1
R:R:G369	R:R:R362	7.51	0	No	Yes	4	4	2	1
R:R:R362	R:R:Y372	7.2	0	Yes	Yes	4	7	1	2
R:R:D373	R:R:R362	11.91	0	No	Yes	5	4	2	1
R:R:M376	R:R:Y372	11.97	9	Yes	Yes	7	7	1	2
R:R:I380	R:R:M376	4.37	0	No	Yes	6	7	2	1
R:R:H377	R:R:H381	9.55	0	Yes	Yes	7	9	1	1
R:R:P207	R:R:V206	3.53	0	No	No	3	3	2	1
R:R:P139	R:R:T138	3.5	0	No	No	3	2	2	1
L:L:L19	R:R:K141	2.82	0	No	No	0	3	0	1
L:L:C1	R:R:Y299	2.69	2	Yes	No	0	7	0	1
L:L:S29	R:R:R126	2.64	0	No	No	0	4	0	1
L:L:T31	R:R:W79	2.43	0	Yes	Yes	0	6	0	1
L:L:T31	R:R:W128	2.43	0	Yes	Yes	0	5	0	1
E:E:G110	L:L:G30	2.11	0	No	No	5	0	1	0
E:E:A104	E:E:G110	1.95	0	No	No	9	5	2	1
R:R:M306	R:R:P360	1.68	2	No	No	4	5	1	2
L:L:L12	R:R:A145	1.58	0	No	No	0	4	0	1
L:L:L16	R:R:A145	1.58	0	No	No	0	4	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7TYY_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.72
Number of Linked Nodes	481
Number of Links	574
Number of Hubs	101
Number of Links mediated by Hubs	343
Number of Communities	13
Number of Nodes involved in Communities	119
Number of Links involved in Communities	170

Path Summary
Number Of Nodes in MetaPath	61
Number Of Links MetaPath	60
Number of Shortest Paths	911551
Length Of Smallest Path	3
Average Path Length	25.1755
Length of Longest Path	43
Minimum Path Strength	1.405
Average Path Strength	7.10509
Maximum Path Strength	21.235
Minimum Path Correlation	0.7
Average Path Correlation	0.964111
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.7037
Average % Of Corr. Nodes	39.6183
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	51.7137
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• molecular transducer activity • coreceptor activity • signaling receptor activity • calcitonin family binding • amide binding • binding • adrenomedullin binding • peptide hormone binding • hormone binding • calcitonin family receptor activity • peptide receptor activity • adrenomedullin receptor activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • transmembrane signaling receptor activity • developmental process • heart development • multicellular organism development • multicellular organismal process • anatomical structure development • animal organ development • circulatory system development • system development • system process • circulatory system process • regulation of blood pressure • biological regulation • regulation of biological quality • blood circulation
Gene Ontology	Biological Process	• developmental process • heart development • multicellular organism development • multicellular organismal process • anatomical structure development • animal organ development • circulatory system development • system development • system process • circulatory system process • regulation of blood pressure • biological regulation • regulation of biological quality • blood circulation • localization • import into cell • receptor internalization • transport • cellular process • receptor-mediated endocytosis • endocytosis • establishment of localization • vesicle-mediated transport • blood vessel morphogenesis • tube development • angiogenesis • vasculature development • anatomical structure morphogenesis • tube morphogenesis • anatomical structure formation involved in morphogenesis • blood vessel development • regulation of biosynthetic process • regulation of biological process • regulation of cellular process • positive regulation of biological process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • positive regulation of macromolecule biosynthetic process • regulation of gene expression • positive regulation of metabolic process • biosynthetic process • positive regulation of gene expression • positive regulation of biosynthetic process • regulation of macromolecule biosynthetic process • metabolic process • positive regulation of macromolecule metabolic process • macromolecule metabolic process • regulation of metabolic process • positive regulation of cellular process • regulation of developmental process • cellular developmental process • regulation of vasculogenesis • regulation of cell differentiation • vasculogenesis • positive regulation of developmental process • positive regulation of cell differentiation • cell differentiation • positive regulation of vasculogenesis • protein localization • establishment of protein localization • cellular localization • nitrogen compound transport • protein transport • cellular macromolecule localization • macromolecule localization • smooth muscle cell differentiation • cell development • muscle cell differentiation • muscle structure development • vascular associated smooth muscle cell differentiation • muscle cell development • vascular associated smooth muscle cell development • protein localization to cell periphery • protein localization to plasma membrane • localization within membrane • protein localization to membrane • cellular response to stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to stimulus • response to hormone • response to endogenous stimulus • response to chemical • cellular response to hormone stimulus • sprouting angiogenesis • negative regulation of vascular permeability • regulation of vascular permeability • vascular process in circulatory system • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • bicellular tight junction assembly • tight junction organization • apical junction assembly • cellular component organization • cellular component biogenesis • cell junction organization • cellular component assembly • cell junction assembly • tight junction assembly • cellular component organization or biogenesis • cell-cell junction assembly • cell-cell junction organization • intracellular transport • establishment of localization in cell • intracellular protein transport • regulation of signaling • regulation of signal transduction • regulation of response to stimulus • regulation of cell communication • regulation of G protein-coupled receptor signaling pathway • adrenomedullin receptor signaling pathway • calcitonin family receptor signaling pathway • regulation of vasculature development • regulation of multicellular organismal process • regulation of anatomical structure morphogenesis • regulation of multicellular organismal development • positive regulation of angiogenesis • positive regulation of vasculature development • regulation of angiogenesis • positive regulation of multicellular organismal process • extracellular matrix organization • basement membrane assembly • extracellular matrix assembly • basement membrane organization • extracellular structure organization • external encapsulating structure organization • amylin receptor signaling pathway • amylin receptor 2 signaling pathway • monoatomic ion transport • monoatomic cation transport • calcium ion transport • metal ion transport • negative regulation of endothelial cell apoptotic process • negative regulation of programmed cell death • regulation of apoptotic process • negative regulation of biological process • regulation of programmed cell death • cell death • negative regulation of apoptotic process • negative regulation of cellular process • endothelial cell apoptotic process • apoptotic process • programmed cell death • regulation of endothelial cell apoptotic process • adherens junction organization • adherens junction assembly • cellular response to growth factor stimulus • cellular response to vascular endothelial growth factor stimulus • response to growth factor • cellular anatomical structure • clathrin-coated pit • membrane • endomembrane system • cell surface • cell periphery • plasma membrane • intracellular anatomical structure • cytoplasm • protein-containing complex • plasma membrane protein complex • membrane protein complex • receptor complex • G protein-coupled receptor dimeric complex
Gene Ontology	Cellular Component	• cellular anatomical structure • clathrin-coated pit • membrane • endomembrane system • cell surface • cell periphery • plasma membrane • intracellular anatomical structure • cytoplasm • protein-containing complex • plasma membrane protein complex • membrane protein complex • receptor complex • G protein-coupled receptor dimeric complex • adrenomedullin receptor complex • plasma membrane signaling receptor complex • G protein-coupled receptor complex • calcitonin family receptor complex • membrane-bounded organelle • intracellular organelle • organelle • lytic vacuole • vacuole • intracellular membrane-bounded organelle • lysosome • calcitonin receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • molecular transducer activity • molecular function activator activity • signaling receptor activity • signaling receptor activator activity • hormone activity • molecular function regulator activity • signaling receptor regulator activity • receptor ligand activity • extracellular region • extracellular space • amide binding • amyloid-beta binding • peptide binding • calcitonin family receptor activity • peptide receptor activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • transmembrane signaling receptor activity • calcitonin receptor activity • amylin receptor activity • calcitonin gene-related peptide receptor activity • calcitonin binding • calcitonin family binding • peptide hormone binding • hormone binding • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • cellular response to stimulus • positive regulation of cell communication • regulation of cellular process • positive regulation of signal transduction • response to stimulus • signaling • positive regulation of biological process • regulation of signal transduction • intracellular signal transduction • cell communication • positive regulation of response to stimulus • regulation of intracellular signal transduction • intracellular signaling cassette • regulation of calcium-mediated signaling • positive regulation of calcium-mediated signaling • signal transduction • positive regulation of cellular process • regulation of biological process • regulation of signaling • positive regulation of intracellular signal transduction • regulation of response to stimulus • calcium-mediated signaling • regulation of cell communication • cellular process • positive regulation of signaling • catabolic process • negative regulation of biological process • RNA metabolic process • macromolecule catabolic process • regulation of primary metabolic process • nucleobase-containing compound metabolic process • post-transcriptional regulation of gene expression • regulation of RNA metabolic process • regulation of mRNA catabolic process • negative regulation of cellular process • regulation of nucleobase-containing compound metabolic process • RNA catabolic process • negative regulation of macromolecule metabolic process • regulation of biosynthetic process • mRNA catabolic process • negative regulation of metabolic process • primary metabolic process • regulation of macromolecule metabolic process • regulation of catabolic process • gene expression • mRNA metabolic process • macromolecule biosynthetic process • nucleic acid metabolic process • nucleobase-containing compound catabolic process • regulation of mRNA stability • regulation of gene expression • negative regulation of gene expression • biosynthetic process • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • regulation of RNA stability • nucleic acid catabolic process • metabolic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • regulation of mRNA metabolic process • regulation of metabolic process • positive regulation of ERK1 and ERK2 cascade • positive regulation of MAPK cascade • regulation of MAPK cascade • MAPK cascade • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of macromolecule biosynthetic process • positive regulation of metabolic process • positive regulation of gene expression • positive regulation of biosynthetic process • positive regulation of macromolecule metabolic process • amylin receptor 1 signaling pathway • amylin receptor signaling pathway • calcitonin family receptor signaling pathway • G protein-coupled receptor signaling pathway • regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • phosphatidylinositol 3-kinase/protein kinase B signal transduction • response to corticosteroid • response to lipid • response to hormone • response to steroid hormone • response to chemical • response to endogenous stimulus • response to glucocorticoid • adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • response to amyloid-beta • cell surface receptor signaling pathway • calcitonin gene-related peptide receptor signaling pathway • multicellular organismal process • ossification • amylin receptor 2 signaling pathway • developmental process • myeloid leukocyte differentiation • cellular developmental process • hemopoiesis • cell development • myeloid cell differentiation • cell differentiation • osteoclast differentiation • anatomical structure development • leukocyte differentiation • positive regulation of cAMP/PKA signal transduction • cAMP/PKA signal transduction • regulation of cAMP/PKA signal transduction • regulation of multicellular organismal process • negative regulation of multicellular organismal process • regulation of ossification • negative regulation of ossification • amylin receptor 3 signaling pathway • cell projection • cilium • plasma membrane bounded cell projection • amylin receptor complex • amylin receptor complex 3 • amylin receptor complex 2 • amylin receptor complex 1 • axon • neuron projection • acrosomal vesicle • intracellular vesicle • cytoplasmic vesicle • secretory granule • secretory vesicle • vesicle • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • phosphorus-oxygen lyase activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • adenylate cyclase activator activity • adenylate cyclase activity • cation binding • metal ion binding • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to nitrogen compound • response to peptide hormone • cellular response to peptide hormone stimulus • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • homeostatic process • adaptive thermogenesis • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • protein localization • regulation of localization • establishment of protein localization • nitrogen compound transport • localization • cellular macromolecule localization • regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • protein transport • regulation of cellular localization • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • extrinsic component of plasma membrane • catalytic complex • cytoplasmic side of membrane • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular membrane-bounded organelle • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • trans-Golgi network • organelle membrane • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of taste • sensory organ development • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • cell population proliferation • small GTPase-mediated signal transduction • Ras protein signal transduction • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • vacuolar membrane • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation
SCOP2	Domain Identifier	• RAMP1-like • G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• RAMP1-like • G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	NH2
PDB Residues	L:L:?33
Environment Details	Open EMBL-EBI Page
Code	NH2
Name	AMINO GROUP
Synonyms
Identifier
Formula	H2 N
Molecular Weight	16.023
SMILES
PubChem	123329
Formal Charge	0
Total Atoms	3
Total Chiral Atoms	0
Total Bonds	2
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	E
Protein	RAMP2
UniProt	O60895
Sequence	>7TYY_nogp_Chain_E N Y E T A V Q F C W N H Y K D Q M D P I E K D W C D W A M I S R P Y S T L R D C L E H F A E L F D L G F P N P L A E R I I F E T H Q I H F A N C S L V D P P E D V L L A M I I A P I C L I P F L I T L V V Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	R
Protein	Receptor
UniProt	P30988
Sequence	>7TYY_nogp_Chain_R K P F L Y V V G R K K M M D A Q Y K C Y D R M Q Q L P A Y Q G E G P Y C N R T W D G W L C W D D T P A G V L S Y Q F C P D Y F P D F D P S E K V T K Y C D E K G V W F K H P E N N R T W S N Y T M C N A F T P E K L K N A Y V L Y Y L A I V G H S L S I F T L V I S L G I F V F F R S L G C Q R V T L H K N M F L T Y I L N S M I I I I H L V E V V P N G E L V R R D P V S C K I L H F F H Q Y M M A C N Y F W M L C E G I Y L H T L I V V A V F T E K Q R L R W Y Y L L G W G F P L V P T T I H A I T R A V Y F N D N C W L S V E T H L L Y I I H G P V M A A L V V N F F F L L N I V R V L V T K M R E T H E A E S H M Y L K A V K A T M I L V P L L G I Q F V V F P W R P S N K M L G K I Y D Y V M H S L I H F Q G F F V A T I Y C F C N N E V Q T T V K R Q Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7TYX	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Amylin	-	Gs/β1/γ2; RAMP2	2.55	2022-03-30	10.1126/science.abm9609
	7TYX (No Gprot)	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Amylin	-		2.55	2022-03-30	10.1126/science.abm9609
	7TYY	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Calcitonin-1	-	Gs/β1/γ2; RAMP2	3	2022-03-23	10.1126/science.abm9609
	7TYY (No Gprot)	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Calcitonin-1	-		3	2022-03-23	10.1126/science.abm9609
	7TYH	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Calcitonin-1	-	Gs/β1/γ2; RAMP2	3.3	2022-03-23	10.1126/science.abm9609
	7TYH (No Gprot)	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Calcitonin-1	-		3.3	2022-03-23	10.1126/science.abm9609

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7TYY_nogp.zip

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You can also read or download a guide explaining the meaning of all files and numerical data.