Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1E:E:W69 4.075406
2E:E:M76 10.555419
3E:E:I79 11.225417
4E:E:W83 13.414517
5E:E:Y93 7.632519
6E:E:R97 6.5875417
7E:E:F103 4.19167671
8E:E:F111 7.302518
9E:E:E117 6.9025418
10E:E:H124 11.708519
11E:E:F128 10.5275419
12E:E:P141 4.978509
13L:L:C1 5.555420
14L:L:T6 5.754520
15L:L:L9 5.715420
16L:L:H17 8.28410
17L:L:T21 6.625410
18L:L:Y22 6.17333610
19L:L:T31 2.7675400
20L:L:P32 8.94410
21L:L:?33 7.5075410
22R:R:Y41 6.7925413
23R:R:M49 6.0975414
24R:R:Q52 9.535416
25R:R:Y53 14.26411
26R:R:Y56 10.898513
27R:R:R74 9.11404
28R:R:W76 8.2518
29R:R:D77 7.404519
30R:R:W79 10.7933616
31R:R:W82 9.722519
32R:R:T85 6.1675417
33R:R:P96 7.3075419
34R:R:Y98 5.75604
35R:R:F99 12.545415
36R:R:P100 7.07414
37R:R:F102 8.49429714
38R:R:E106 7.005404
39R:R:K110 14.3475418
40R:R:Y111 6.31414
41R:R:E114 4.175412
42R:R:W118 11.99519
43R:R:H121 9.6225414
44R:R:W128 9.684515
45R:R:S129 7.958517
46R:R:N130 10.8125418
47R:R:Y131 7.98833615
48R:R:N135 7.4625413
49R:R:Y146 6.1875402
50R:R:Y149 7.35505
51R:R:H156 8.8225407
52R:R:I160 3.7675465
53R:R:F170 6.7865108
54R:R:F173 4.698507
55R:R:V181 6.64254109
56R:R:L183 5.146538
57R:R:H184 6.2225439
58R:R:K185 4.564106
59R:R:F188 5.4325408
60R:R:Y191 10.8267628
61R:R:I192 3.6475467
62R:R:N194 6.6425408
63R:R:I198 8.2175427
64R:R:H201 5.82496
65R:R:K220 6.994117
66R:R:F224 4.625405
67R:R:H226 6.8025426
68R:R:Q227 6.86167627
69R:R:N233 8.53429
70R:R:F235 5.754555
71R:R:W236 8.67739
72R:R:L238 6.4125408
73R:R:E240 7.1675439
74R:R:I242 5.784537
75R:R:Y243 9.702538
76R:R:H245 11.762508
77R:R:Q257 9.1925435
78R:R:Y262 6.438537
79R:R:F269 5.385453
80R:R:P270 5.3475459
81R:R:R281 11.76407
82R:R:F285 7.37546
83R:R:D287 7.5075443
84R:R:W290 13.054119
85R:R:L298 6.4425426
86R:R:I301 8.1825427
87R:R:H302 7.71667626
88R:R:F313 5.29406
89R:R:F315 9.775438
90R:R:M327 6.345407
91R:R:L351 8.9625439
92R:R:L352 4.2525409
93R:R:Q355 7.79528
94R:R:F356 7.68571727
95R:R:F359 4.9486
96R:R:R362 8.1625404
97R:R:Y372 8.26487
98R:R:M376 6.48487
99R:R:H377 8.9625407
100R:R:H381 8.2125409
101R:R:Q383 9.7525429
102R:R:F385 6.525405
103R:R:Y391 8.004538
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1L:L:S29 R:R:E123 10.13735.75NoNo004
2R:R:E123 R:R:H121 10.55666.15NoYes044
3R:R:H121 R:R:W128 11.336320.1YesYes145
4L:L:T31 R:R:W128 18.26472.43YesYes005
5L:L:T31 R:R:W79 19.49062.43YesYes006
6R:R:M48 R:R:W79 62.85655.82NoYes066
7E:E:R97 R:R:M48 66.40233.72YesNo076
8E:E:Y93 R:R:Q52 12.388113.53YesYes196
9E:E:R97 R:R:M49 77.00766.2YesYes174
10R:R:M49 R:R:R45 98.55793.72YesNo047
11R:R:R45 R:R:V42 98.91883.92NoNo071
12R:R:K46 R:R:V42 99.63994.55NoNo041
13R:R:K46 R:R:V43 1004.55NoNo042
14R:R:F285 R:R:V43 67.16246.55YesNo462
15R:R:F285 R:R:T295 34.078211.67YesNo064
16R:R:F39 R:R:V43 33.1956.55NoNo442
17R:R:D287 R:R:F39 33.29234.78YesNo434
18R:R:D287 R:R:R281 66.781710.72YesYes037
19R:R:H277 R:R:R281 85.166510.16NoYes077
20R:R:H277 R:R:L298 38.690510.29NoYes076
21R:R:H302 R:R:L298 20.83525.14YesYes266
22L:L:T6 R:R:H302 41.786710.95YesYes206
23R:R:D287 R:R:F285 33.29547.17YesYes436
24R:R:R281 R:R:T295 36.49635.17YesNo074
25R:R:H277 R:R:I301 46.48599.28NoYes077
26R:R:H302 R:R:I301 21.0419.28YesYes267
27R:R:F99 R:R:W79 17.563815.03YesYes156
28R:R:F99 R:R:Y41 16.86534.13YesYes153
29L:L:T6 R:R:F356 35.92563.89YesYes207
30R:R:L298 R:R:Q227 17.43143.99YesYes267
31R:R:H226 R:R:Q227 13.9474.95YesYes267
32L:L:L9 R:R:H226 10.86015.14YesYes206
33R:R:I301 R:R:Q227 17.61689.61YesYes277
34R:R:R281 R:R:W290 18.183520.99YesYes079
35R:R:H223 R:R:W290 17.73811.64NoYes059
36R:R:H223 R:R:Q227 17.67712.36NoYes057
37L:L:Y22 R:R:Y41 12.2314.96YesYes103
38L:L:H17 L:L:Y22 10.15857.62YesYes100
39R:R:D77 R:R:W82 12.27456.7YesYes199
40R:R:W118 R:R:W82 14.76723.75YesYes199
41R:R:T85 R:R:W118 10.26999.7YesYes179
42R:R:W79 R:R:Y131 14.972313.5YesYes165
43R:R:M230 R:R:Q227 38.51264.08NoYes267
44R:R:M230 R:R:N194 38.24678.41NoYes068
45R:R:N194 R:R:N233 37.82645.45YesYes089
46R:R:N233 R:R:Y191 34.842318.61YesYes298
47R:R:V387 R:R:Y191 53.747910.09NoYes098
48R:R:F188 R:R:V387 37.37133.93YesNo089
49R:R:F188 R:R:S166 12.87255.28YesNo089
50R:R:C392 R:R:S166 11.79056.89NoNo099
51R:R:C392 R:R:F393 22.69134.19NoNo098
52R:R:F393 R:R:T162 11.88763.89NoNo086
53R:R:F385 R:R:F386 12.97254.29YesNo055
54R:R:F356 R:R:Q383 24.12974.68YesYes279
55R:R:Q383 R:R:Y191 23.749914.65YesYes298
56R:R:F170 R:R:F188 23.52136.43YesYes088
57R:R:C392 R:R:F170 11.99064.19NoYes098
58R:R:V387 R:R:Y391 16.87543.79NoYes098
59E:E:F111 E:E:R97 11.215611.76YesYes187
60R:R:M49 R:R:Q52 20.82716.8YesYes146
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
E:E:L109 R:R:R126 6.07 0 No No 7 4 2 1
E:E:F111 E:E:P112 5.78 1 Yes No 8 9 2 1
E:E:E117 E:E:F111 9.33 1 Yes Yes 8 8 2 2
E:E:E117 E:E:P112 9.43 1 Yes No 8 9 2 1
E:E:P112 L:L:P32 3.9 1 No Yes 9 0 1 0
H:H:?1 R:R:H121 4.61 1 No Yes 0 4 2 2
H:H:?1 R:R:W128 6.13 1 No Yes 0 5 2 1
H:H:?1 R:R:N130 24.64 1 No Yes 0 8 2 2
L:L:C1 R:R:L298 6.35 2 Yes Yes 0 6 0 1
L:L:C1 R:R:H302 5.9 2 Yes Yes 0 6 0 1
L:L:S2 R:R:E294 5.75 0 No No 0 3 0 1
L:L:N3 R:R:W361 10.17 0 No No 0 4 0 1
L:L:N3 R:R:R362 6.03 0 No Yes 0 4 0 1
L:L:L4 R:R:M306 5.65 2 No No 0 4 0 1
L:L:L4 R:R:W361 4.56 2 No No 0 4 0 1
L:L:S5 R:R:F356 7.93 0 No Yes 0 7 0 1
L:L:S5 R:R:M376 4.6 0 No Yes 0 7 0 1
L:L:T6 R:R:Y234 4.99 2 Yes No 0 7 0 1
L:L:T6 R:R:H302 10.95 2 Yes Yes 0 6 0 1
L:L:T6 R:R:M306 4.52 2 Yes No 0 4 0 1
L:L:T6 R:R:F356 3.89 2 Yes Yes 0 7 0 1
L:L:C7 R:R:H302 8.85 2 No Yes 0 6 0 1
L:L:V8 R:R:H377 8.3 0 No Yes 0 7 0 1
L:L:L9 R:R:I198 7.14 2 Yes Yes 0 7 0 1
L:L:L9 R:R:L202 4.15 2 Yes No 0 7 0 1
L:L:L9 R:R:H226 5.14 2 Yes Yes 0 6 0 1
L:L:L9 R:R:H381 6.43 2 Yes Yes 0 9 0 1
L:L:L12 R:R:H377 6.43 0 No Yes 0 7 0 1
L:L:S13 R:R:H201 5.58 9 No Yes 0 6 0 1
L:L:S13 R:R:V206 6.46 9 No No 0 3 0 1
L:L:Q14 R:R:V293 4.3 0 No No 0 6 0 1
L:L:Q14 R:R:E294 11.47 0 No No 0 3 0 1
L:L:L16 R:R:Y146 7.03 0 No Yes 0 2 0 1
L:L:L16 R:R:Y149 8.21 0 No Yes 0 5 0 1
L:L:H17 R:R:V212 6.92 1 Yes No 0 3 0 1
L:L:H17 R:R:L291 9 1 Yes No 0 6 0 1
L:L:K18 R:R:P100 5.02 0 No Yes 0 4 0 1
L:L:L19 R:R:T138 8.84 0 No No 0 2 0 1
L:L:L19 R:R:L142 4.15 0 No No 0 2 0 1
L:L:Q20 R:R:Y146 7.89 0 No Yes 0 2 0 1
L:L:T21 R:R:G209 5.46 1 Yes No 0 3 0 1
L:L:T21 R:R:R213 6.47 1 Yes No 0 2 0 1
L:L:Y22 R:R:P38 11.13 1 Yes No 0 5 0 1
L:L:Y22 R:R:Y41 4.96 1 Yes Yes 0 3 0 1
L:L:Y22 R:R:P100 6.95 1 Yes Yes 0 4 0 1
L:L:R24 R:R:N135 8.44 0 No Yes 0 3 0 1
L:L:T25 R:R:F99 18.16 1 No Yes 0 5 0 1
L:L:T25 R:R:D101 8.67 1 No No 0 4 0 1
L:L:T25 R:R:F102 6.49 1 No Yes 0 4 0 1
L:L:T27 R:R:N135 8.77 0 No Yes 0 3 0 1
L:L:S29 R:R:E123 5.75 0 No No 0 4 0 1
L:L:P32 R:R:D77 4.83 1 Yes Yes 0 9 0 1
L:L:P32 R:R:W79 22.97 1 Yes Yes 0 6 0 1
L:L:?33 R:R:D77 10.08 1 Yes Yes 0 9 0 1
L:L:?33 R:R:W128 8.46 1 Yes Yes 0 5 0 1
L:L:?33 R:R:S129 7.43 1 Yes Yes 0 7 0 1
R:R:P38 R:R:Y41 8.34 1 No Yes 5 3 1 1
R:R:L40 R:R:P100 6.57 0 No Yes 5 4 2 1
R:R:F99 R:R:Y41 4.13 1 Yes Yes 5 3 1 1
R:R:P100 R:R:Y41 9.74 1 Yes Yes 4 3 1 1
R:R:M48 R:R:W79 5.82 0 No Yes 6 6 2 1
R:R:D77 R:R:W82 6.7 1 Yes Yes 9 9 1 2
R:R:D77 R:R:S129 7.36 1 Yes Yes 9 7 1 1
R:R:D77 R:R:Y131 8.05 1 Yes Yes 9 5 1 2
R:R:F99 R:R:W79 15.03 1 Yes Yes 5 6 1 1
R:R:F102 R:R:W79 5.01 1 Yes Yes 4 6 1 1
R:R:W79 R:R:Y131 13.5 1 Yes Yes 6 5 1 2
R:R:K110 R:R:W82 20.89 1 Yes Yes 8 9 2 2
R:R:S129 R:R:W82 7.41 1 Yes Yes 7 9 1 2
R:R:F102 R:R:P96 4.33 1 Yes Yes 4 9 1 2
R:R:P96 R:R:Y131 4.17 1 Yes Yes 9 5 2 2
R:R:F102 R:R:F99 12.86 1 Yes Yes 4 5 1 1
R:R:D101 R:R:F102 9.55 1 No Yes 4 4 1 1
R:R:D101 R:R:N135 5.39 1 No Yes 4 3 1 1
R:R:C134 R:R:F102 13.97 0 No Yes 9 4 2 1
R:R:F102 R:R:N135 7.25 1 Yes Yes 4 3 1 1
R:R:K110 R:R:S129 13.77 1 Yes Yes 8 7 2 1
R:R:E123 R:R:H121 6.15 0 No Yes 4 4 1 2
R:R:H121 R:R:W128 20.1 1 Yes Yes 4 5 2 1
R:R:N124 R:R:R126 19.28 0 No No 5 4 2 1
R:R:N130 R:R:W128 11.3 1 Yes Yes 8 5 2 1
R:R:S129 R:R:Y131 3.82 1 Yes Yes 7 5 1 2
R:R:L142 R:R:Y146 5.86 0 No Yes 2 2 1 1
R:R:Y146 R:R:Y150 3.97 0 Yes No 2 4 1 2
R:R:D373 R:R:L148 5.43 0 No No 5 5 2 2
R:R:H377 R:R:L148 11.57 0 Yes No 7 5 1 2
R:R:Y149 R:R:Y150 6.95 0 Yes No 5 4 1 2
R:R:I153 R:R:Y149 7.25 0 No Yes 7 5 2 1
R:R:L202 R:R:Y149 10.55 0 No Yes 7 5 1 1
R:R:V203 R:R:Y149 3.79 0 No Yes 3 5 2 1
R:R:A152 R:R:H381 7.32 0 No Yes 7 9 2 1
R:R:H156 R:R:I198 11.93 0 Yes Yes 7 7 2 1
R:R:H156 R:R:H381 9.55 0 Yes Yes 7 9 2 1
R:R:I198 R:R:N194 8.5 2 Yes Yes 7 8 1 2
R:R:M230 R:R:N194 8.41 2 No Yes 6 8 2 2
R:R:H226 R:R:I198 5.3 2 Yes Yes 6 7 1 1
R:R:H201 R:R:V205 6.92 9 Yes No 6 7 1 2
R:R:H201 R:R:V206 6.92 9 Yes No 6 3 1 1
R:R:H201 R:R:L291 3.86 9 Yes No 6 6 1 1
R:R:G209 R:R:R213 4.5 1 No No 3 2 1 1
R:R:C289 R:R:V212 5.12 0 No No 9 3 2 1
R:R:H226 R:R:Q227 4.95 2 Yes Yes 6 7 1 2
R:R:H226 R:R:M230 11.82 2 Yes No 6 6 1 2
R:R:M230 R:R:Q227 4.08 2 No Yes 6 7 2 2
R:R:L298 R:R:Q227 3.99 2 Yes Yes 6 7 1 2
R:R:I301 R:R:Q227 9.61 2 Yes Yes 7 7 2 2
R:R:H302 R:R:Q227 6.18 2 Yes Yes 6 7 1 2
R:R:V305 R:R:Y234 10.09 0 No No 7 7 2 1
R:R:F356 R:R:Y234 8.25 2 Yes No 7 7 1 1
R:R:H277 R:R:L298 10.29 0 No Yes 7 6 2 1
R:R:H277 R:R:I301 9.28 0 No Yes 7 7 2 2
R:R:C289 R:R:L291 4.76 0 No No 9 6 2 1
R:R:H296 R:R:Y299 6.53 0 No No 2 7 2 1
R:R:H302 R:R:L298 5.14 2 Yes Yes 6 6 1 1
R:R:H302 R:R:I301 9.28 2 Yes Yes 6 7 1 2
R:R:F356 R:R:L309 4.87 2 Yes No 7 7 1 2
R:R:F356 R:R:Q355 12.88 2 Yes Yes 7 8 1 2
R:R:Q355 R:R:Q383 11.52 2 Yes Yes 8 9 2 2
R:R:F356 R:R:I380 11.3 2 Yes No 7 6 1 2
R:R:F356 R:R:Q383 4.68 2 Yes Yes 7 9 1 2
R:R:F359 R:R:Y372 4.13 8 Yes Yes 6 7 2 2
R:R:F359 R:R:M376 4.98 8 Yes Yes 6 7 2 1
R:R:G369 R:R:R362 7.51 0 No Yes 4 4 2 1
R:R:R362 R:R:Y372 7.2 0 Yes Yes 4 7 1 2
R:R:D373 R:R:R362 11.91 0 No Yes 5 4 2 1
R:R:M376 R:R:Y372 11.97 8 Yes Yes 7 7 1 2
R:R:I380 R:R:M376 4.37 0 No Yes 6 7 2 1
R:R:H377 R:R:H381 9.55 0 Yes Yes 7 9 1 1
R:R:P207 R:R:V206 3.53 0 No No 3 3 2 1
R:R:P139 R:R:T138 3.5 0 No No 3 2 2 1
L:L:L19 R:R:K141 2.82 0 No No 0 3 0 1
L:L:C1 R:R:Y299 2.69 2 Yes No 0 7 0 1
L:L:S29 R:R:R126 2.64 0 No No 0 4 0 1
L:L:T31 R:R:W79 2.43 0 Yes Yes 0 6 0 1
L:L:T31 R:R:W128 2.43 0 Yes Yes 0 5 0 1
E:E:G110 L:L:G30 2.11 0 No No 5 0 1 0
E:E:A104 E:E:G110 1.95 0 No No 9 5 2 1
R:R:M306 R:R:P360 1.68 2 No No 4 5 1 2
L:L:L12 R:R:A145 1.58 0 No No 0 4 0 1
L:L:L16 R:R:A145 1.58 0 No No 0 4 0 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 7TYY_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 3.72
Number of Linked Nodes 482
Number of Links 577
Number of Hubs 103
Number of Links mediated by Hubs 350
Number of Communities 12
Number of Nodes involved in Communities 123
Number of Links involved in Communities 177
Path Summary
Number Of Nodes in MetaPath 61
Number Of Links MetaPath 60
Number of Shortest Paths 915331
Length Of Smallest Path 3
Average Path Length 25.1664
Length of Longest Path 43
Minimum Path Strength 1.405
Average Path Strength 7.10261
Maximum Path Strength 21.235
Minimum Path Correlation 0.7
Average Path Correlation 0.963966
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 3.7037
Average % Of Corr. Nodes 39.4697
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 52.2839
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain   • G protein-coupled receptor-like   • RAMP1-like
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain   • G protein-coupled receptor-like   • RAMP1-like
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeNAG
PDB ResiduesH:H:?1
Environment DetailsOpen EMBL-EBI Page
CodeNAG
NameN-Acetylglucosamine
SynonymsN-Acetylchitosamine
Identifier
FormulaC8 H15 N O6
Molecular Weight221.208
SMILES
PubChem24139
Formal Charge0
Total Atoms30
Total Chiral Atoms5
Total Bonds30
Total Aromatic Bonds0

CodeNH2
PDB ResiduesL:L:?33
Environment DetailsOpen EMBL-EBI Page
CodeNH2
NameAMINO GROUP
Synonyms
Identifier
FormulaH2 N
Molecular Weight16.023
SMILES
PubChem123329
Formal Charge0
Total Atoms3
Total Chiral Atoms0
Total Bonds2
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainE
ProteinRAMP2
UniProtO60895
Sequence
>7TYY_nogp_Chain_E
NYETAVQFC WNHYKDQMD PIEKDWCDW AMISRPYST LRDCLEHFA 
ELFDLGFPN PLAERIIFE THQIHFANC SLVDPPEDV LLAMIIAPI 
CLIPFLITL VV


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainL
ProteinCalcitonin-1
UniProtB5XGR7
Sequence
>7TYY_nogp_Chain_L


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP30988
Sequence
>7TYY_nogp_Chain_R
KPFLYVVGR KKMMDAQYK CYDRMQQLP AYQGEGPYC NRTWDGWLC 
WDDTPAGVL SYQFCPDYF PDFDPSEKV TKYCDEKGV WFKHPENNR 
TWSNYTMCN AFTPEKLKN AYVLYYLAI VGHSLSIFT LVISLGIFV 
FFRSLGCQR VTLHKNMFL TYILNSMII IIHLVEVVP NGELVRRDP 
VSCKILHFF HQYMMACNY FWMLCEGIY LHTLIVVAV FTEKQRLRW 
YYLLGWGFP LVPTTIHAI TRAVYFNDN CWLSVETHL LYIIHGPVM 
AALVVNFFF LLNIVRVLV TKMRETHEA ESHMYLKAV KATMILVPL 
LGIQFVVFP WRPSNKMLG KIYDYVMHS LIHFQGFFV ATIYCFCNN 
EVQTTVKRQ


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7TYHB1PeptideCalcitoninCT (AMY2)Homo sapiensCalcitonin-Gs/β1/γ2; RAMP23.32022-03-23doi.org/10.1126/science.abm9609
7TYH (No Gprot) B1PeptideCalcitoninCT (AMY2)Homo sapiensCalcitonin-3.32022-03-23doi.org/10.1126/science.abm9609
7TYYB1PeptideCalcitoninCT (AMY2)Homo sapiensCalcitonin-1-Gs/β1/γ2; RAMP232022-03-23doi.org/10.1126/science.abm9609
7TYY (No Gprot) B1PeptideCalcitoninCT (AMY2)Homo sapiensCalcitonin-1-32022-03-23doi.org/10.1126/science.abm9609
7TYXB1PeptideCalcitoninCT (AMY2)Homo sapiensAmylin-Gs/β1/γ2; RAMP22.552022-03-30doi.org/10.1126/science.abm9609
7TYX (No Gprot) B1PeptideCalcitoninCT (AMY2)Homo sapiensAmylin-2.552022-03-30doi.org/10.1126/science.abm9609
9BQ3B1PeptideCalcitoninCT (AMY2)Homo sapiensCagrilintide-Gs/β1/γ2; RAMP22.82025-04-23doi.org/10.1038/s41467-025-58680-y
9BQ3 (No Gprot) B1PeptideCalcitoninCT (AMY2)Homo sapiensCagrilintide-2.82025-04-23doi.org/10.1038/s41467-025-58680-y




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Download 7TYY_nogp.zip



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