psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	E:E:E62	E:E:N60	13.15	No	No	0	3	3
2	E:E:V65	E:E:Y61	7.57	No	Yes	0	5	8
3	E:E:L100	E:E:Y61	3.52	No	Yes	0	8	8
4	E:E:F103	E:E:Y61	4.13	Yes	Yes	0	1	8
5	E:E:A104	E:E:Y61	8.01	No	Yes	0	9	8
6	E:E:F107	E:E:Y61	4.13	No	Yes	0	5	8
7	E:E:N113	E:E:Y61	4.65	Yes	Yes	0	9	8
8	E:E:A64	E:E:F103	5.55	No	Yes	0	3	1
9	E:E:C68	E:E:C99	7.28	No	No	0	9	9
10	E:E:I119	E:E:W69	11.74	No	No	0	5	6
11	E:E:T123	E:E:W69	4.85	No	No	0	8	6
12	E:E:W83	E:E:Y72	10.61	Yes	No	0	7	9
13	E:E:Y72	E:E:Y93	3.97	No	Yes	0	9	9
14	E:E:L96	E:E:Y72	18.76	No	No	0	8	9
15	E:E:P92	E:E:Q75	9.47	No	No	0	6	3
16	E:E:M76	E:E:W83	12.8	No	Yes	7	9	7
17	E:E:H127	E:E:M76	10.51	Yes	No	7	8	9
18	E:E:D77	E:E:E80	3.9	No	No	0	4	5
19	E:E:I79	E:E:M88	10.2	No	No	0	7	5
20	E:E:I89	E:E:W83	7.05	No	Yes	0	8	7
21	E:E:H127	E:E:W83	27.51	Yes	Yes	7	8	7
22	E:E:C131	E:E:C84	7.28	No	No	0	9	9
23	E:E:W86	R:R:Y53	6.75	No	No	0	9	1
24	E:E:I89	E:E:Y93	3.63	No	Yes	0	8	9
25	E:E:I120	E:E:Y93	4.84	Yes	Yes	1	9	9
26	E:E:H124	E:E:Y93	8.71	Yes	Yes	1	9	9
27	E:E:Y93	R:R:M49	5.99	Yes	No	1	9	4
28	E:E:Y93	R:R:Q52	14.65	Yes	Yes	1	9	6
29	E:E:Y93	R:R:Y53	3.97	Yes	No	1	9	1
30	E:E:E101	E:E:R97	22.1	No	Yes	1	8	7
31	E:E:F111	E:E:R97	18.17	Yes	Yes	1	8	7
32	E:E:R97	R:R:R45	7.46	Yes	No	0	7	7
33	E:E:R97	R:R:M48	3.72	Yes	No	0	7	6
34	E:E:R97	R:R:M49	6.2	Yes	No	1	7	4
35	E:E:R97	R:R:Q52	4.67	Yes	Yes	1	7	6
36	E:E:F111	E:E:L100	4.87	Yes	No	0	8	8
37	E:E:A116	E:E:L100	4.73	No	No	0	9	8
38	E:E:E101	E:E:F111	7	No	Yes	1	8	8
39	E:E:L109	E:E:N113	8.24	No	Yes	6	7	9
40	E:E:L109	E:E:P114	8.21	No	No	6	7	5
41	E:E:L109	R:R:R126	3.64	No	No	0	7	4
42	E:E:F111	R:R:Q52	8.2	Yes	Yes	1	8	6
43	E:E:N113	E:E:P114	6.52	Yes	No	6	9	5
44	E:E:L115	E:E:N113	9.61	No	Yes	0	4	9
45	E:E:E117	E:E:R118	4.65	No	No	0	8	4
46	E:E:H124	E:E:I120	5.3	Yes	Yes	1	9	9
47	E:E:I120	R:R:Q52	4.12	Yes	Yes	1	9	6
48	E:E:I120	R:R:Y56	10.88	Yes	Yes	1	9	3
49	E:E:E122	E:E:Q125	7.65	No	No	0	4	5
50	E:E:F128	E:E:H124	11.31	Yes	Yes	1	9	9
51	E:E:H124	R:R:Y53	7.62	Yes	No	1	9	1
52	E:E:H124	R:R:Y56	8.71	Yes	Yes	1	9	3
53	E:E:A129	E:E:Q125	4.55	No	No	0	6	5
54	E:E:H127	E:E:I126	13.26	Yes	No	0	8	5
55	E:E:F128	E:E:S132	3.96	Yes	No	1	9	8
56	E:E:F128	R:R:D57	4.78	Yes	No	0	9	4
57	E:E:F128	R:R:Q60	12.88	Yes	No	1	9	3
58	E:E:S132	R:R:Q60	5.78	No	No	1	8	3
59	E:E:L146	E:E:L147	4.15	No	No	0	8	7
60	E:E:L146	R:R:H296	6.43	No	No	0	8	2
61	E:E:I150	R:R:Y299	4.84	No	No	0	9	7
62	E:E:I154	R:R:P304	6.77	No	Yes	0	9	9
63	E:E:I154	R:R:A307	3.25	No	No	0	9	3
64	E:E:I157	E:E:P158	6.77	No	No	0	9	9
65	E:E:I157	E:E:I161	4.42	No	No	0	9	9
66	E:E:I157	R:R:F269	3.77	No	No	0	9	3
67	E:E:L160	R:R:L265	5.54	No	Yes	0	9	7
68	E:E:V164	R:R:Y262	7.57	No	Yes	0	9	7
69	E:E:V165	R:R:T246	4.76	No	No	0	9	7
70	L:L:C1	L:L:G2	3.92	No	No	0	0	0
71	L:L:C1	L:L:C7	7.28	No	No	0	0	0
72	L:L:C1	R:R:Y299	5.38	No	No	0	0	7
73	L:L:N3	R:R:W361	4.52	No	No	0	0	4
74	L:L:N3	R:R:R362	10.85	No	Yes	0	0	4
75	L:L:C7	L:L:L4	4.76	No	No	0	0	0
76	L:L:L4	R:R:W361	3.42	No	No	0	0	4
77	L:L:S5	R:R:F356	9.25	No	Yes	0	0	7
78	L:L:T6	R:R:H302	9.58	No	Yes	0	0	6
79	L:L:T6	R:R:M306	4.52	No	No	0	0	4
80	L:L:T6	R:R:F356	3.89	No	Yes	0	0	7
81	L:L:C7	R:R:H302	7.37	No	Yes	0	0	6
82	L:L:M8	R:R:Y372	3.59	No	Yes	0	0	7
83	L:L:M8	R:R:H377	5.25	No	No	0	0	7
84	L:L:L9	R:R:I198	7.14	No	Yes	0	0	7
85	L:L:G10	L:L:T13	3.64	No	No	0	0	0
86	L:L:F16	L:L:Y12	15.47	Yes	No	3	0	0
87	L:L:Y12	R:R:L148	4.69	No	No	0	0	5
88	L:L:Y12	R:R:Y149	4.96	No	Yes	3	0	5
89	L:L:D15	L:L:Q14	6.53	No	Yes	0	0	0
90	L:L:K18	L:L:Q14	8.14	No	Yes	0	0	0
91	L:L:Q14	R:R:V293	4.3	Yes	No	0	0	6
92	L:L:F16	L:L:H20	4.53	Yes	No	3	0	0
93	L:L:F16	R:R:Y146	15.47	Yes	Yes	3	0	2
94	L:L:F16	R:R:Y149	10.32	Yes	Yes	3	0	5
95	L:L:F16	R:R:V206	5.24	Yes	No	0	0	3
96	L:L:N17	L:L:T21	5.85	No	Yes	2	0	0
97	L:L:N17	R:R:V212	7.39	No	No	2	0	3
98	L:L:N17	R:R:L291	8.24	No	Yes	2	0	6
99	L:L:F22	L:L:K18	3.72	Yes	No	2	0	0
100	L:L:K18	R:R:P100	3.35	No	Yes	2	0	4
101	L:L:F19	R:R:L142	4.87	No	No	0	0	2
102	L:L:H20	R:R:Y146	6.53	No	Yes	3	0	2
103	L:L:F22	L:L:T21	11.67	Yes	Yes	2	0	0
104	L:L:T21	R:R:G209	3.64	Yes	No	2	0	3
105	L:L:T21	R:R:V212	9.52	Yes	No	2	0	3
106	L:L:T21	R:R:R213	6.47	Yes	No	2	0	2
107	L:L:F22	R:R:L40	8.53	Yes	No	2	0	5
108	L:L:F22	R:R:Y41	6.19	Yes	Yes	2	0	3
109	L:L:F22	R:R:P100	13	Yes	Yes	2	0	4
110	L:L:T25	R:R:F99	5.19	No	No	12	0	5
111	L:L:T25	R:R:D101	11.56	No	No	0	0	4
112	L:L:T25	R:R:F102	3.89	No	Yes	12	0	4
113	L:L:I27	R:R:T132	4.56	No	No	0	0	6
114	L:L:?33	L:L:G28	4.23	Yes	No	0	0	0
115	L:L:G28	R:R:W128	4.22	No	Yes	0	0	5
116	L:L:V29	R:R:W128	4.9	No	Yes	0	0	5
117	L:L:A31	L:L:P32	3.74	No	Yes	0	0	0
118	L:L:?33	L:L:P32	4.06	Yes	Yes	1	0	0
119	L:L:P32	R:R:D77	4.83	Yes	Yes	1	0	9
120	L:L:P32	R:R:G78	4.06	Yes	No	1	0	5
121	L:L:P32	R:R:W79	5.4	Yes	Yes	0	0	6
122	L:L:?33	R:R:D77	3.36	Yes	Yes	1	0	9
123	L:L:?33	R:R:S129	7.43	Yes	Yes	1	0	7
124	L:L:?33	R:R:Y131	5.8	Yes	Yes	1	0	5
125	R:R:K37	R:R:V42	4.55	No	No	0	4	1
126	R:R:P38	R:R:Y41	15.3	No	Yes	0	5	3
127	R:R:D287	R:R:F39	10.75	No	No	0	3	4
128	R:R:L40	R:R:P100	3.28	No	Yes	2	5	4
129	R:R:L40	R:R:S292	6.01	No	No	0	5	4
130	R:R:P100	R:R:Y41	8.34	Yes	Yes	2	4	3
131	R:R:D97	R:R:K47	5.53	No	No	0	2	4
132	R:R:K47	R:R:Y98	7.17	No	Yes	0	4	4
133	R:R:M48	R:R:W79	4.65	No	Yes	0	6	6
134	R:R:M48	R:R:Y98	9.58	No	Yes	0	6	4
135	R:R:M49	R:R:Q52	5.44	No	Yes	1	4	6
136	R:R:A51	R:R:K54	4.82	No	No	0	8	4
137	R:R:Q52	R:R:Y56	4.51	Yes	Yes	1	6	3
138	R:R:Q52	R:R:W76	5.48	Yes	Yes	1	6	8
139	R:R:C55	R:R:K54	4.85	No	No	0	9	4
140	R:R:C55	R:R:W76	5.22	No	Yes	0	9	8
141	R:R:C55	R:R:C81	7.28	No	No	0	9	9
142	R:R:W76	R:R:Y56	11.58	Yes	Yes	1	8	3
143	R:R:Q61	R:R:R58	11.68	No	No	0	3	3
144	R:R:R58	R:R:R74	5.33	No	Yes	0	3	4
145	R:R:M59	R:R:R74	12.41	No	Yes	0	5	4
146	R:R:L62	R:R:P63	4.93	No	No	0	3	1
147	R:R:D84	R:R:Y65	3.45	No	No	0	4	3
148	R:R:G67	R:R:Y71	4.35	No	No	0	2	3
149	R:R:G69	R:R:P70	4.06	No	No	0	1	1
150	R:R:N73	R:R:Y71	20.93	No	No	0	4	3
151	R:R:D84	R:R:Y71	11.49	No	No	0	4	3
152	R:R:C72	R:R:T85	5.07	No	No	0	9	7
153	R:R:C112	R:R:C72	7.28	No	No	1	9	9
154	R:R:C72	R:R:W118	5.22	No	Yes	1	9	9
155	R:R:C81	R:R:R74	6.96	No	Yes	0	9	4
156	R:R:D83	R:R:R74	3.57	No	Yes	0	5	4
157	R:R:G78	R:R:W76	8.44	No	Yes	1	5	8
158	R:R:D77	R:R:G78	3.35	Yes	No	1	9	5
159	R:R:D77	R:R:W82	6.7	Yes	Yes	1	9	9
160	R:R:D77	R:R:K110	5.53	Yes	Yes	1	9	8
161	R:R:D77	R:R:Y131	8.05	Yes	Yes	1	9	5
162	R:R:F99	R:R:W79	8.02	No	Yes	0	5	6
163	R:R:W79	R:R:Y131	19.29	Yes	Yes	0	6	5
164	R:R:L80	R:R:Q93	6.65	No	No	0	5	6
165	R:R:S91	R:R:W82	4.94	No	Yes	0	5	9
166	R:R:Q93	R:R:W82	23	No	Yes	0	6	9
167	R:R:V108	R:R:W82	3.68	No	Yes	0	7	9
168	R:R:K110	R:R:W82	31.33	Yes	Yes	1	8	9
169	R:R:S129	R:R:W82	3.71	Yes	Yes	1	7	9
170	R:R:D83	R:R:D84	3.99	No	No	0	5	4
171	R:R:P86	R:R:T85	3.5	No	No	0	2	7
172	R:R:L90	R:R:Y92	5.86	No	No	0	4	4
173	R:R:L90	R:R:Y111	9.38	No	No	0	4	4
174	R:R:K107	R:R:Y92	4.78	No	No	0	3	4
175	R:R:T109	R:R:Y92	7.49	No	No	0	5	4
176	R:R:C134	R:R:C95	7.28	No	No	0	9	9
177	R:R:P96	R:R:Y98	13.91	No	Yes	0	9	4
178	R:R:F102	R:R:F99	10.72	Yes	No	12	4	5
179	R:R:D101	R:R:P100	3.22	No	Yes	0	4	4
180	R:R:D101	R:R:N135	5.39	No	Yes	0	4	3
181	R:R:C134	R:R:F102	8.38	No	Yes	0	9	4
182	R:R:F102	R:R:N135	4.83	Yes	Yes	0	4	3
183	R:R:D103	R:R:S105	5.89	No	No	13	3	1
184	R:R:D103	R:R:E106	5.2	No	Yes	13	3	4
185	R:R:E106	R:R:S105	7.19	Yes	No	13	4	1
186	R:R:E106	R:R:K107	4.05	Yes	No	0	4	3
187	R:R:K107	R:R:M133	10.08	No	No	0	3	5
188	R:R:N130	R:R:T109	7.31	No	No	0	8	5
189	R:R:M133	R:R:T109	9.03	No	No	0	5	5
190	R:R:K110	R:R:W118	9.28	Yes	Yes	1	8	9
191	R:R:K110	R:R:S129	13.77	Yes	Yes	1	8	7
192	R:R:C112	R:R:W118	19.59	No	Yes	1	9	9
193	R:R:D113	R:R:F119	3.58	No	No	0	5	4
194	R:R:F119	R:R:K120	6.2	No	No	0	4	1
195	R:R:H121	R:R:P122	9.15	No	No	0	4	5
196	R:R:H121	R:R:W128	33.85	No	Yes	0	4	5
197	R:R:N124	R:R:R126	4.82	No	No	0	5	4
198	R:R:N124	R:R:W128	7.91	No	Yes	0	5	5
199	R:R:S129	R:R:Y131	8.9	Yes	Yes	1	7	5
200	R:R:N135	R:R:T138	10.24	Yes	No	0	3	2
201	R:R:F137	R:R:K366	3.72	No	No	0	1	3
202	R:R:P139	R:R:T138	3.5	No	No	0	3	2
203	R:R:E140	R:R:P139	6.29	No	No	0	2	3
204	R:R:K141	R:R:N144	6.99	No	No	0	3	4
205	R:R:L142	R:R:Y146	4.69	No	Yes	0	2	2
206	R:R:N144	R:R:Y374	9.3	No	Yes	0	4	6
207	R:R:Y146	R:R:Y150	3.97	Yes	No	0	2	4
208	R:R:L148	R:R:Y374	7.03	No	Yes	0	5	6
209	R:R:H377	R:R:L148	14.14	No	No	0	7	5
210	R:R:Y149	R:R:Y150	3.97	Yes	No	0	5	4
211	R:R:I153	R:R:Y149	6.04	No	Yes	0	7	5
212	R:R:L202	R:R:Y149	5.86	No	Yes	0	7	5
213	R:R:F382	R:R:L151	3.65	No	No	0	7	5
214	R:R:A152	R:R:H381	7.32	No	No	0	7	9
215	R:R:F382	R:R:G155	9.03	No	No	0	7	8
216	R:R:H156	R:R:S195	6.97	Yes	No	0	7	7
217	R:R:H156	R:R:I198	7.95	Yes	Yes	0	7	7
218	R:R:H156	R:R:H381	10.75	Yes	No	0	7	9
219	R:R:F385	R:R:L158	4.87	No	No	0	5	4
220	R:R:S159	R:R:S195	6.52	No	No	0	9	7
221	R:R:G384	R:R:S159	3.71	No	No	0	9	9
222	R:R:I160	R:R:I192	4.42	Yes	Yes	4	5	7
223	R:R:I160	R:R:S195	6.19	Yes	No	0	5	7
224	R:R:F161	R:R:T162	3.89	No	No	0	4	6
225	R:R:F385	R:R:T162	10.38	No	No	0	5	6
226	R:R:F188	R:R:L163	7.31	Yes	No	0	8	8
227	R:R:I192	R:R:L163	5.71	Yes	No	0	7	8
228	R:R:F188	R:R:S166	6.61	Yes	No	0	8	9
229	R:R:A388	R:R:S166	3.42	No	No	0	8	9
230	R:R:C392	R:R:S166	6.89	No	No	0	9	9
231	R:R:F170	R:R:V181	7.87	Yes	No	0	8	9
232	R:R:F170	R:R:H184	5.66	Yes	No	0	8	9
233	R:R:F170	R:R:F188	6.43	Yes	Yes	0	8	8
234	R:R:K185	R:R:V171	4.55	No	No	0	6	4
235	R:R:F173	R:R:V402	5.24	Yes	No	0	7	5
236	R:R:F173	R:R:Q405	10.54	Yes	No	0	7	4
237	R:R:L176	R:R:T401	11.79	No	No	0	9	7
238	R:R:G177	R:R:V181	3.68	No	No	0	7	9
239	R:R:Q179	R:R:Y243	10.15	No	Yes	0	7	8
240	R:R:K256	R:R:Q179	5.42	No	No	0	5	7
241	R:R:R180	R:R:V181	3.92	No	No	0	9	9
242	R:R:H184	R:R:R180	4.51	No	No	0	9	9
243	R:R:E397	R:R:R180	4.65	No	No	0	9	9
244	R:R:E240	R:R:L183	3.98	Yes	No	0	9	8
245	R:R:L183	R:R:Y243	5.86	No	Yes	9	8	8
246	R:R:L183	R:R:Y262	4.69	No	Yes	9	8	7
247	R:R:E240	R:R:H184	11.08	Yes	No	0	9	9
248	R:R:N186	R:R:W236	12.43	No	Yes	14	9	9
249	R:R:N186	R:R:Y263	15.12	No	No	0	9	5
250	R:R:N186	R:R:W267	4.52	No	Yes	14	9	9
251	R:R:M187	R:R:Y191	7.18	No	Yes	0	8	8
252	R:R:E240	R:R:M187	6.77	Yes	No	0	9	8
253	R:R:F188	R:R:V387	3.93	Yes	No	0	8	9
254	R:R:L189	R:R:W267	5.69	No	Yes	0	3	9
255	R:R:C232	R:R:T190	5.07	No	No	0	8	9
256	R:R:N233	R:R:T190	10.24	Yes	No	0	9	9
257	R:R:T190	R:R:W236	4.85	No	Yes	0	9	9
258	R:R:N233	R:R:Y191	12.79	Yes	Yes	5	9	8
259	R:R:M237	R:R:Y191	5.99	Yes	Yes	5	9	8
260	R:R:Q383	R:R:Y191	13.53	No	Yes	5	9	8
261	R:R:V387	R:R:Y191	6.31	No	Yes	0	9	8
262	R:R:L193	R:R:M229	4.24	No	No	0	6	4
263	R:R:I198	R:R:N194	8.5	Yes	No	0	7	8
264	R:R:N194	R:R:N233	6.81	No	Yes	0	8	9
265	R:R:H226	R:R:I198	5.3	No	Yes	0	6	7
266	R:R:H201	R:R:V205	6.92	No	Yes	2	6	7
267	R:R:H201	R:R:L222	5.14	No	No	0	6	6
268	R:R:H201	R:R:L291	6.43	No	Yes	2	6	6
269	R:R:E204	R:R:V205	5.7	No	Yes	0	4	7
270	R:R:C289	R:R:V205	3.42	No	Yes	0	9	7
271	R:R:L291	R:R:V205	4.47	Yes	Yes	2	6	7
272	R:R:P207	R:R:V206	3.53	No	No	0	3	3
273	R:R:E210	R:R:N208	3.94	No	No	0	3	3
274	R:R:L211	R:R:N208	8.24	No	No	0	1	3
275	R:R:G209	R:R:R213	4.5	No	No	2	3	2
276	R:R:E210	R:R:R214	3.49	No	No	0	3	4
277	R:R:L211	R:R:P216	4.93	No	Yes	0	1	4
278	R:R:P216	R:R:R214	5.76	Yes	No	0	4	4
279	R:R:D215	R:R:P216	4.83	No	Yes	0	6	4
280	R:R:D215	R:R:K220	12.44	No	No	0	6	7
281	R:R:C289	R:R:D215	4.67	No	No	0	9	6
282	R:R:P216	R:R:S218	3.56	Yes	No	0	4	3
283	R:R:C219	R:R:P216	5.65	No	Yes	0	9	4
284	R:R:C219	R:R:C289	7.28	No	No	0	9	9
285	R:R:K220	R:R:W290	19.73	No	Yes	0	7	9
286	R:R:H223	R:R:Q227	12.36	No	Yes	0	5	7
287	R:R:H223	R:R:W290	13.75	No	Yes	0	5	9
288	R:R:F224	R:R:F225	5.36	Yes	No	0	5	5
289	R:R:F224	R:R:T274	5.19	Yes	No	0	5	6
290	R:R:H226	R:R:Q227	4.95	No	Yes	0	6	7
291	R:R:M230	R:R:Q227	5.44	No	Yes	11	6	7
292	R:R:I301	R:R:Q227	9.61	No	Yes	0	7	7
293	R:R:H302	R:R:Q227	4.95	Yes	Yes	11	6	7
294	R:R:M229	R:R:Y228	3.59	No	No	0	4	8
295	R:R:L271	R:R:Y228	9.38	No	No	0	4	8
296	R:R:T274	R:R:Y228	4.99	No	No	0	6	8
297	R:R:M230	R:R:Y234	7.18	No	Yes	0	6	7
298	R:R:H302	R:R:M230	5.25	Yes	No	11	6	6
299	R:R:C232	R:R:W267	5.22	No	Yes	0	8	9
300	R:R:C232	R:R:P270	3.77	No	Yes	0	8	9
301	R:R:M237	R:R:N233	4.21	Yes	Yes	5	9	9
302	R:R:M237	R:R:Y234	3.59	Yes	Yes	0	9	7
303	R:R:V305	R:R:Y234	6.31	No	Yes	0	7	7
304	R:R:F356	R:R:Y234	6.19	Yes	Yes	0	7	7
305	R:R:F235	R:R:L265	3.65	Yes	Yes	8	5	7
306	R:R:F235	R:R:F269	7.5	Yes	No	8	5	3
307	R:R:F235	R:R:P270	4.33	Yes	Yes	0	5	9
308	R:R:C239	R:R:W236	6.53	No	Yes	0	7	9
309	R:R:G266	R:R:W236	8.44	No	Yes	0	9	9
310	R:R:W236	R:R:W267	14.06	Yes	Yes	14	9	9
311	R:R:M237	R:R:Q383	6.8	Yes	No	5	9	9
312	R:R:I242	R:R:L238	7.14	No	No	0	7	8
313	R:R:A308	R:R:L238	4.73	No	No	0	7	8
314	R:R:L238	R:R:N312	9.61	No	No	0	8	9
315	R:R:C239	R:R:L265	4.76	No	Yes	0	7	7
316	R:R:E240	R:R:L351	5.3	Yes	No	0	9	9
317	R:R:I242	R:R:Y262	4.84	No	Yes	0	7	7
318	R:R:F315	R:R:I242	3.77	No	No	0	8	7
319	R:R:L247	R:R:Y243	10.55	No	Yes	0	8	8
320	R:R:Y243	R:R:Y262	7.94	Yes	Yes	9	8	7
321	R:R:I319	R:R:L244	5.71	No	No	0	9	9
322	R:R:H245	R:R:V249	13.84	Yes	No	15	8	6
323	R:R:H245	R:R:V250	4.15	Yes	No	0	8	5
324	R:R:F315	R:R:H245	19.23	No	Yes	0	8	8
325	R:R:H245	R:R:N318	8.93	Yes	No	15	8	8
326	R:R:I248	R:R:I319	4.42	No	No	0	7	9
327	R:R:N318	R:R:V249	10.35	No	No	15	8	6
328	R:R:Q257	R:R:Y262	3.38	No	Yes	0	5	7
329	R:R:R258	R:R:R260	10.66	No	No	0	5	3
330	R:R:L259	R:R:Y262	3.52	No	Yes	0	5	7
331	R:R:L259	R:R:Y263	5.86	No	No	0	5	5
332	R:R:F269	R:R:L265	4.87	No	Yes	8	3	7
333	R:R:P273	R:R:V272	5.3	No	No	0	6	4
334	R:R:P273	R:R:P304	3.9	No	Yes	0	6	9
335	R:R:I276	R:R:I300	4.42	No	No	0	5	8
336	R:R:H277	R:R:R281	11.28	Yes	Yes	0	7	7
337	R:R:H277	R:R:L298	3.86	Yes	No	0	7	6
338	R:R:H277	R:R:I300	3.98	Yes	No	0	7	8
339	R:R:H277	R:R:I301	13.26	Yes	No	0	7	7
340	R:R:L297	R:R:T280	7.37	No	No	0	4	4
341	R:R:D287	R:R:R281	7.15	No	Yes	0	3	7
342	R:R:R281	R:R:W290	16.99	Yes	Yes	0	7	9
343	R:R:R281	R:R:T295	3.88	Yes	No	0	7	4
344	R:R:V283	R:R:Y284	5.05	No	No	0	3	2
345	R:R:F285	R:R:Y284	4.13	No	No	0	6	2
346	R:R:F285	R:R:T295	6.49	No	No	16	6	4
347	R:R:F285	R:R:L297	7.31	No	No	16	6	4
348	R:R:N286	R:R:W290	4.52	No	Yes	0	7	9
349	R:R:D287	R:R:S292	8.83	No	No	0	3	4
350	R:R:L297	R:R:T295	4.42	No	No	16	4	4
351	R:R:H296	R:R:Y299	5.44	No	No	0	2	7
352	R:R:H302	R:R:L298	6.43	Yes	No	0	6	6
353	R:R:G303	R:R:P304	4.06	No	Yes	0	4	9
354	R:R:F356	R:R:L309	8.53	Yes	No	0	7	7
355	R:R:F314	R:R:V310	5.24	No	No	0	5	4
356	R:R:F315	R:R:V311	7.87	No	No	0	8	6
357	R:R:F313	R:R:L317	7.31	No	No	0	6	5
358	R:R:F313	R:R:I354	3.77	No	Yes	0	6	6
359	R:R:F313	R:R:V357	10.49	No	No	0	6	7
360	R:R:L316	R:R:L348	4.15	No	No	0	9	9
361	R:R:I354	R:R:L316	4.28	Yes	No	0	6	9
362	R:R:N318	R:R:R321	10.85	No	No	0	8	8
363	R:R:K326	R:R:V322	4.55	No	No	0	9	8
364	R:R:R328	R:R:V324	6.54	No	No	0	6	5
365	R:R:E332	R:R:T330	4.23	No	No	0	5	5
366	R:R:E332	R:R:H336	6.15	No	No	0	5	6
367	R:R:E334	R:R:Y338	4.49	No	No	0	6	7
368	R:R:K340	R:R:K343	5.75	No	No	0	8	8
369	R:R:I347	R:R:I390	5.89	No	No	0	8	8
370	R:R:L348	R:R:Y391	4.69	No	No	0	9	8
371	R:R:P350	R:R:V349	3.53	No	No	0	9	8
372	R:R:L351	R:R:Y391	12.89	No	No	0	9	8
373	R:R:G353	R:R:Q355	4.93	No	Yes	0	9	8
374	R:R:F356	R:R:Q355	11.71	Yes	Yes	0	7	8
375	R:R:L379	R:R:Q355	3.99	No	Yes	0	5	8
376	R:R:Q355	R:R:Q383	10.24	Yes	No	0	8	9
377	R:R:F356	R:R:I380	6.28	Yes	No	0	7	6
378	R:R:F359	R:R:V358	7.87	No	No	0	6	5
379	R:R:F359	R:R:Y372	5.16	No	Yes	0	6	7
380	R:R:G369	R:R:R362	4.5	No	Yes	0	4	4
381	R:R:R362	R:R:Y372	8.23	Yes	Yes	10	4	7
382	R:R:D373	R:R:R362	13.1	No	Yes	10	5	4
383	R:R:L368	R:R:P363	3.28	No	No	0	3	7
384	R:R:P363	R:R:Y372	6.95	No	Yes	0	7	7
385	R:R:L368	R:R:N365	4.12	No	No	0	3	4
386	R:R:L368	R:R:M367	5.65	No	No	0	3	4
387	R:R:D373	R:R:Y372	3.45	No	Yes	10	5	7
388	R:R:I380	R:R:M376	4.37	No	No	0	6	7
389	R:R:H377	R:R:H381	9.55	No	No	0	7	9
390	R:R:F382	R:R:F386	3.22	No	No	0	7	5
391	R:R:F385	R:R:F386	4.29	No	No	0	5	5
392	R:R:I390	R:R:Y391	7.25	No	No	0	8	8
393	R:R:E397	R:R:N395	6.57	No	No	0	9	9
394	R:R:N395	R:R:V398	5.91	No	No	0	9	9
395	R:R:V310	R:R:V357	3.21	No	No	0	4	7
396	R:R:T85	R:R:V89	3.17	No	No	0	7	5
397	R:R:I354	R:R:V349	3.07	Yes	No	0	6	8
398	R:R:K46	R:R:V42	3.04	No	No	0	4	1
399	R:R:L176	R:R:V398	2.98	No	No	0	9	9
400	R:R:N365	R:R:S364	2.98	No	No	0	4	4
401	L:L:L9	L:L:T13	2.95	No	No	0	0	0
402	L:L:T13	R:R:L291	2.95	No	Yes	0	0	6
403	R:R:L259	R:R:T182	2.95	No	No	0	5	5
404	E:E:I79	E:E:M76	2.92	No	No	0	7	9
405	E:E:M149	R:R:I276	2.92	No	No	0	9	5
406	R:R:I160	R:R:M196	2.92	Yes	No	4	5	4
407	R:R:I192	R:R:M196	2.92	Yes	No	4	7	4
408	R:R:I197	R:R:M229	2.92	No	No	0	5	4
409	R:R:G88	R:R:Y111	2.9	No	No	0	8	4
410	E:E:F111	E:E:P112	2.89	Yes	No	0	8	9
411	R:R:F235	R:R:P304	2.89	Yes	Yes	0	5	9
412	R:R:M327	R:R:M337	2.89	No	No	0	7	7
413	R:R:F386	R:R:P350	2.89	No	No	0	5	9
414	E:E:P92	E:E:R91	2.88	No	Yes	0	6	6
415	R:R:I197	R:R:L222	2.85	No	No	0	5	6
416	R:R:I354	R:R:L352	2.85	Yes	No	0	6	9
417	L:L:I27	R:R:N135	2.83	No	Yes	0	0	3
418	R:R:K185	R:R:L167	2.82	No	No	0	6	6
419	R:R:K120	R:R:N125	2.8	No	No	0	1	7
420	E:E:C99	E:E:F103	2.79	No	Yes	0	9	1
421	L:L:P23	R:R:Y41	2.78	No	Yes	0	0	3
422	L:L:F16	R:R:A145	2.77	Yes	No	0	0	4
423	R:R:A278	R:R:F224	2.77	No	Yes	0	6	5
424	R:R:L244	R:R:L348	2.77	No	No	0	9	9
425	E:E:H124	E:E:T123	2.74	Yes	No	0	9	8
426	E:E:H127	E:E:T123	2.74	Yes	No	0	8	8
427	R:R:E332	R:R:M337	2.71	No	No	0	5	7
428	E:E:E80	E:E:K81	2.7	No	No	0	5	5
429	R:R:E255	R:R:K256	2.7	No	No	0	6	5
430	R:R:H156	R:R:I199	2.65	Yes	No	0	7	7
431	E:E:R91	E:E:S94	2.64	Yes	No	0	6	8
432	R:R:F172	R:R:V171	2.62	No	No	0	2	4
433	R:R:H336	R:R:K340	2.62	No	No	0	6	8
434	E:E:F67	E:E:T63	2.59	No	No	0	1	3
435	E:E:R91	E:E:T95	2.59	Yes	No	0	6	2
436	R:R:R126	R:R:T127	2.59	No	No	0	4	4
437	R:R:F224	R:R:T275	2.59	Yes	No	0	5	3
438	L:L:Q14	R:R:E294	2.55	Yes	No	0	0	3
439	R:R:V203	R:R:Y149	2.52	No	Yes	0	3	5
440	R:R:F173	R:R:I169	2.51	Yes	No	0	7	8
441	R:R:F225	R:R:I221	2.51	No	No	0	5	4
442	E:E:R91	R:R:K46	2.48	Yes	No	0	6	4
443	R:R:F170	R:R:K185	2.48	Yes	No	0	8	6
444	R:R:M337	R:R:R328	2.48	No	No	0	7	6
445	R:R:T75	R:R:W118	2.43	No	Yes	0	5	9
446	R:R:F39	R:R:N288	2.42	No	No	0	4	4
447	R:R:D113	R:R:Y111	2.3	No	No	0	5	4
448	R:R:L264	R:R:W261	2.28	No	No	0	3	2
449	E:E:F103	E:E:H102	2.26	Yes	No	0	1	1
450	R:R:Q257	R:R:W261	2.19	No	No	0	5	2
451	R:R:F172	R:R:F173	2.14	No	Yes	0	2	7
452	E:E:G110	E:E:P112	2.03	No	No	0	5	9
453	R:R:G116	R:R:P70	2.03	No	No	0	9	1
454	R:R:G268	R:R:P270	2.03	No	Yes	0	6	9
455	R:R:C178	R:R:G177	1.96	No	No	0	8	7
456	E:E:P153	R:R:P304	1.95	No	Yes	0	9	9
457	L:L:A31	L:L:G30	1.95	No	No	0	0	0
458	E:E:A152	E:E:P153	1.87	No	No	0	7	9
459	R:R:A231	R:R:P270	1.87	No	Yes	0	5	9
460	R:R:G44	R:R:V43	1.84	No	No	0	4	2
461	R:R:G116	R:R:V117	1.84	No	No	0	9	5
462	R:R:G168	R:R:V171	1.84	No	No	0	1	4
463	L:L:G2	L:L:T11	1.82	No	No	0	0	0
464	L:L:A26	L:L:A31	1.79	No	No	0	0	0
465	R:R:G241	R:R:L244	1.71	No	No	0	8	9
466	R:R:G241	R:R:L352	1.71	No	No	0	8	9
467	R:R:A251	R:R:V250	1.7	No	No	0	6	5
468	R:R:A341	R:R:V324	1.7	No	No	0	9	5
469	R:R:A251	R:R:T246	1.68	No	No	0	6	7
470	R:R:K37	R:R:P38	1.67	No	No	0	4	5
471	E:E:C155	E:E:I151	1.64	No	No	0	7	6
472	E:E:D77	E:E:P78	1.61	No	No	0	4	5
473	R:R:D103	R:R:P104	1.61	No	No	0	3	3
474	R:R:V249	R:R:V322	1.6	No	No	0	6	8
475	R:R:V320	R:R:V324	1.6	No	No	0	7	5
476	E:E:T162	E:E:V165	1.59	No	No	0	8	9
477	R:R:T345	R:R:V320	1.59	No	No	0	9	7
478	E:E:P78	E:E:Q75	1.58	No	No	0	5	3
479	R:R:A344	R:R:L323	1.58	No	No	0	9	9
480	E:E:C131	E:E:N130	1.57	No	No	0	9	9
481	R:R:T400	R:R:T401	1.57	No	No	0	4	7
482	E:E:C84	E:E:D85	1.56	No	No	0	9	7
483	E:E:C99	E:E:D98	1.56	No	No	0	9	1
484	R:R:A282	R:R:N286	1.56	No	No	0	3	7
485	R:R:I153	R:R:S157	1.55	No	No	0	7	7
486	R:R:I199	R:R:S157	1.55	No	No	0	7	7
487	R:R:I160	R:R:V164	1.54	Yes	No	4	5	4
488	R:R:I165	R:R:V164	1.54	No	No	0	5	4
489	R:R:I192	R:R:V164	1.54	Yes	No	4	7	4
490	R:R:I221	R:R:V217	1.54	No	No	0	4	3
491	E:E:M149	E:E:V145	1.52	No	No	0	9	7
492	R:R:C95	R:R:E106	1.52	No	Yes	0	9	4
493	R:R:K143	R:R:V147	1.52	No	No	0	1	4
494	R:R:I279	R:R:T280	1.52	No	No	0	3	4
495	R:R:I390	R:R:T389	1.52	No	No	0	8	5
496	R:R:L151	R:R:S378	1.5	No	No	0	5	5
497	R:R:L176	R:R:S175	1.5	No	No	0	9	8
498	R:R:L316	R:R:V320	1.49	No	No	0	9	7
499	E:E:C68	E:E:H71	1.47	No	No	0	9	1
500	E:E:I150	E:E:I151	1.47	No	No	0	9	6
501	E:E:L163	E:E:T162	1.47	No	No	0	9	8
502	R:R:N396	R:R:T400	1.46	No	No	0	6	4
503	R:R:G44	R:R:Y98	1.45	No	Yes	0	4	4
504	R:R:I371	R:R:K370	1.45	No	No	0	5	4
505	R:R:F359	R:R:P360	1.44	No	No	0	6	5
506	E:E:Q66	E:E:V65	1.43	No	No	0	4	5
507	R:R:I200	R:R:L222	1.43	No	No	0	6	6
508	R:R:L323	R:R:M327	1.41	No	No	0	9	7
509	R:R:E329	R:R:T325	1.41	No	No	0	6	7
510	R:R:K340	R:R:L339	1.41	No	No	0	8	6
511	R:R:C392	R:R:F393	1.4	No	No	0	9	8
512	E:E:D82	E:E:M88	1.39	No	No	0	6	5
513	E:E:E122	E:E:I126	1.37	No	No	0	4	5
514	R:R:E106	R:R:K366	1.35	Yes	No	0	4	3
515	R:R:E329	R:R:K326	1.35	No	No	0	6	9
516	R:R:L62	R:R:Q61	1.33	No	No	0	3	3
517	L:L:Q24	R:R:N135	1.32	No	Yes	0	0	3
518	R:R:R404	R:R:T401	1.29	No	No	0	7	7
519	E:E:H71	E:E:N70	1.28	No	No	0	1	2
520	R:R:V147	R:R:Y374	1.26	No	Yes	0	4	6
521	E:E:F121	R:R:M59	1.24	No	No	0	6	5
522	R:R:E123	R:R:H121	1.23	No	No	0	4	4
523	E:E:F107	E:E:L106	1.22	No	No	0	5	1
524	R:R:K370	R:R:Y374	1.19	No	Yes	0	4	6
525	E:E:D85	E:E:W86	1.12	No	No	0	7	9
526	R:R:R260	R:R:W261	1	No	No	0	3	2

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	E:E:Y61	5.335	6	0	8
2	E:E:W83	14.4925	4	7	7
3	E:E:R91	2.6475	4	0	6
4	E:E:Y93	6.53714	7	1	9
5	E:E:R97	10.3867	6	1	7
6	E:E:F103	3.6825	4	0	1
7	E:E:F111	8.226	5	1	8
8	E:E:N113	7.255	4	6	9
9	E:E:I120	6.285	4	1	9
10	E:E:H124	7.39833	6	1	9
11	E:E:H127	13.505	4	7	8
12	E:E:F128	8.2325	4	1	9
13	L:L:Q14	5.38	4	0	0
14	L:L:F16	8.96667	6	3	0
15	L:L:T21	7.43	5	2	0
16	L:L:F22	8.622	5	2	0
17	L:L:P32	4.418	5	1	0
18	L:L:?33	4.976	5	1	0
19	R:R:Y41	8.1525	4	2	3
20	R:R:Q52	6.72429	7	1	6
21	R:R:Y56	8.92	4	1	3
22	R:R:R74	7.0675	4	0	4
23	R:R:W76	7.68	4	1	8
24	R:R:D77	5.30333	6	1	9
25	R:R:W79	9.34	4	0	6
26	R:R:W82	12.2267	6	1	9
27	R:R:Y98	8.0275	4	0	4
28	R:R:P100	6.238	5	2	4
29	R:R:F102	6.955	4	12	4
30	R:R:E106	3.862	5	13	4
31	R:R:K110	14.9775	4	1	8
32	R:R:W118	9.13	4	1	9
33	R:R:W128	12.72	4	0	5
34	R:R:S129	8.4525	4	1	7
35	R:R:Y131	10.51	4	1	5
36	R:R:N135	4.922	5	0	3
37	R:R:Y146	7.665	4	3	2
38	R:R:Y149	5.61167	6	3	5
39	R:R:H156	7.08	4	0	7
40	R:R:I160	3.7675	4	4	5
41	R:R:F170	5.61	4	0	8
42	R:R:F173	5.1075	4	0	7
43	R:R:F188	6.07	4	0	8
44	R:R:Y191	9.16	5	5	8
45	R:R:I192	3.6475	4	4	7
46	R:R:I198	7.2225	4	0	7
47	R:R:V205	5.1275	4	2	7
48	R:R:P216	4.946	5	0	4
49	R:R:F224	3.9775	4	0	5
50	R:R:Q227	7.462	5	11	7
51	R:R:N233	8.5125	4	5	9
52	R:R:Y234	5.8175	4	0	7
53	R:R:F235	4.5925	4	8	5
54	R:R:W236	9.262	5	14	9
55	R:R:M237	5.1475	4	5	9
56	R:R:E240	6.7825	4	0	9
57	R:R:Y243	8.625	4	9	8
58	R:R:H245	11.5375	4	15	8
59	R:R:Y262	5.32333	6	9	7
60	R:R:L265	4.705	4	8	7
61	R:R:W267	7.3725	4	14	9
62	R:R:P270	3	4	0	9
63	R:R:H277	8.095	4	0	7
64	R:R:R281	9.825	4	0	7
65	R:R:W290	13.7475	4	0	9
66	R:R:L291	5.5225	4	2	6
67	R:R:H302	6.716	5	11	6
68	R:R:P304	3.914	5	0	9
69	R:R:I354	3.4925	4	0	6
70	R:R:Q355	7.7175	4	0	8
71	R:R:F356	7.64167	6	0	7
72	R:R:R362	9.17	4	10	4
73	R:R:Y372	5.476	5	10	7
74	R:R:Y374	4.695	4	0	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	E:E:H124	E:E:T123	15.9393	2.74	Yes	No	0	9	8
2	E:E:Y93	R:R:Q52	17.8981	14.65	Yes	Yes	1	9	6
3	E:E:H124	R:R:Y56	10.9614	8.71	Yes	Yes	1	9	3
4	R:R:D101	R:R:P100	100	3.22	No	Yes	0	4	4
5	L:L:T25	R:R:D101	90.1941	11.56	No	No	0	0	4
6	L:L:T25	R:R:F99	82.6051	5.19	No	No	12	0	5
7	R:R:F99	R:R:W79	89.4192	8.02	No	Yes	0	5	6
8	R:R:M48	R:R:W79	53.9121	4.65	No	Yes	0	6	6
9	E:E:R97	R:R:M48	52.0201	3.72	Yes	No	0	7	6
10	E:E:H127	E:E:T123	10.0931	2.74	Yes	No	0	8	8
11	E:E:R97	R:R:M49	16.1397	6.2	Yes	No	1	7	4
12	E:E:E122	E:E:I126	10.4481	1.37	No	No	0	4	5
13	E:E:H127	E:E:I126	13.9275	13.26	Yes	No	0	8	5
14	R:R:H302	R:R:L298	14.1781	6.43	Yes	No	0	6	6
15	R:R:H277	R:R:L298	14.3044	3.86	Yes	No	0	7	6
16	R:R:H277	R:R:R281	20.5358	11.28	Yes	Yes	0	7	7
17	R:R:D287	R:R:R281	26.5393	7.15	No	Yes	0	3	7
18	R:R:D287	R:R:S292	25.5649	8.83	No	No	0	3	4
19	R:R:L40	R:R:S292	25.2566	6.01	No	No	0	5	4
20	R:R:L40	R:R:P100	23.7516	3.28	No	Yes	2	5	4
21	R:R:C232	R:R:P270	10.0904	3.77	No	Yes	0	8	9
22	R:R:C232	R:R:T190	11.4399	5.07	No	No	0	8	9
23	R:R:N233	R:R:T190	20.7316	10.24	Yes	No	0	9	9
24	R:R:N194	R:R:N233	59.0858	6.81	No	Yes	0	8	9
25	R:R:I198	R:R:N194	59.3877	8.5	Yes	No	0	7	8
26	L:L:L9	R:R:I198	72.0316	7.14	No	Yes	0	0	7
27	L:L:L9	L:L:T13	72.1048	2.95	No	No	0	0	0
28	L:L:T13	R:R:L291	72.2841	2.95	No	Yes	0	0	6
29	L:L:N17	R:R:L291	76.5402	8.24	No	Yes	2	0	6
30	L:L:N17	L:L:T21	76.3088	5.85	No	Yes	2	0	0
31	L:L:F22	L:L:T21	76.8495	11.67	Yes	Yes	2	0	0
32	L:L:F22	R:R:P100	71.7883	13	Yes	Yes	2	0	4
33	R:R:L183	R:R:Y262	15.7371	4.69	No	Yes	9	8	7
34	R:R:E240	R:R:L183	19.05	3.98	Yes	No	0	9	8
35	R:R:E240	R:R:M187	44.9315	6.77	Yes	No	0	9	8
36	R:R:M187	R:R:Y191	45.3496	7.18	No	Yes	0	8	8
37	R:R:N233	R:R:Y191	44.6058	12.79	Yes	Yes	5	9	8
38	R:R:I242	R:R:Y262	12.1123	4.84	No	Yes	0	7	7
39	R:R:H156	R:R:I198	30.8366	7.95	Yes	Yes	0	7	7
40	R:R:H156	R:R:H381	17.9823	10.75	Yes	No	0	7	9
41	R:R:H377	R:R:H381	16.8734	9.55	No	No	0	7	9
42	R:R:H377	R:R:L148	10.5112	14.14	No	No	0	7	5
43	R:R:H156	R:R:I199	10.5854	2.65	Yes	No	0	7	7
44	L:L:P32	R:R:W79	22.4378	5.4	Yes	Yes	0	0	6
45	R:R:G78	R:R:W76	14.4142	8.44	No	Yes	1	5	8
46	L:L:P32	R:R:G78	12.6942	4.06	Yes	No	1	0	5
47	R:R:W79	R:R:Y131	14.7271	19.29	Yes	Yes	0	6	5
48	R:R:C134	R:R:F102	19.5943	8.38	No	Yes	0	9	4
49	R:R:C134	R:R:C95	18.7224	7.28	No	No	0	9	9
50	R:R:C95	R:R:E106	17.8487	1.52	No	Yes	0	9	4
51	R:R:E106	R:R:K107	12.5771	4.05	Yes	No	0	4	3
52	R:R:E240	R:R:L351	26.1788	5.3	Yes	No	0	9	9
53	R:R:L351	R:R:Y391	25.6363	12.89	No	No	0	9	8
54	R:R:L348	R:R:Y391	23.4561	4.69	No	No	0	9	8
55	R:R:L316	R:R:L348	20.0747	4.15	No	No	0	9	9
56	R:R:I354	R:R:L316	10.8964	4.28	Yes	No	0	6	9
57	R:R:M230	R:R:Y234	15.5843	7.18	No	Yes	0	6	7
58	R:R:M237	R:R:Y234	14.6228	3.59	Yes	Yes	0	9	7
59	R:R:M230	R:R:Q227	10.0392	5.44	No	Yes	11	6	7
60	E:E:Y93	R:R:M49	15.7728	5.99	Yes	No	1	9	4
61	E:E:R97	R:R:Q52	26.5238	4.67	Yes	Yes	1	7	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
E:E:I150	R:R:Y299	4.84	0	No	No	9	7	2	1
L:L:C1	R:R:Y299	5.38	0	No	No	0	7	0	1
L:L:N3	R:R:W361	4.52	0	No	No	0	4	0	1
L:L:N3	R:R:R362	10.85	0	No	Yes	0	4	0	1
L:L:L4	R:R:W361	3.42	0	No	No	0	4	0	1
L:L:S5	R:R:F356	9.25	0	No	Yes	0	7	0	1
L:L:T6	R:R:H302	9.58	0	No	Yes	0	6	0	1
L:L:T6	R:R:M306	4.52	0	No	No	0	4	0	1
L:L:T6	R:R:F356	3.89	0	No	Yes	0	7	0	1
L:L:C7	R:R:H302	7.37	0	No	Yes	0	6	0	1
L:L:M8	R:R:Y372	3.59	0	No	Yes	0	7	0	1
L:L:M8	R:R:H377	5.25	0	No	No	0	7	0	1
L:L:L9	R:R:I198	7.14	0	No	Yes	0	7	0	1
L:L:Y12	R:R:L148	4.69	3	No	No	0	5	0	1
L:L:Y12	R:R:Y149	4.96	3	No	Yes	0	5	0	1
L:L:Q14	R:R:V293	4.3	0	Yes	No	0	6	0	1
L:L:F16	R:R:Y146	15.47	3	Yes	Yes	0	2	0	1
L:L:F16	R:R:Y149	10.32	3	Yes	Yes	0	5	0	1
L:L:F16	R:R:V206	5.24	3	Yes	No	0	3	0	1
L:L:N17	R:R:V212	7.39	2	No	No	0	3	0	1
L:L:N17	R:R:L291	8.24	2	No	Yes	0	6	0	1
L:L:K18	R:R:P100	3.35	2	No	Yes	0	4	0	1
L:L:F19	R:R:L142	4.87	0	No	No	0	2	0	1
L:L:H20	R:R:Y146	6.53	3	No	Yes	0	2	0	1
L:L:T21	R:R:G209	3.64	2	Yes	No	0	3	0	1
L:L:T21	R:R:V212	9.52	2	Yes	No	0	3	0	1
L:L:T21	R:R:R213	6.47	2	Yes	No	0	2	0	1
L:L:F22	R:R:L40	8.53	2	Yes	No	0	5	0	1
L:L:F22	R:R:Y41	6.19	2	Yes	Yes	0	3	0	1
L:L:F22	R:R:P100	13	2	Yes	Yes	0	4	0	1
L:L:T25	R:R:F99	5.19	12	No	No	0	5	0	1
L:L:T25	R:R:D101	11.56	12	No	No	0	4	0	1
L:L:T25	R:R:F102	3.89	12	No	Yes	0	4	0	1
L:L:I27	R:R:T132	4.56	0	No	No	0	6	0	1
L:L:G28	R:R:W128	4.22	0	No	Yes	0	5	0	1
L:L:V29	R:R:W128	4.9	0	No	Yes	0	5	0	1
L:L:P32	R:R:D77	4.83	1	Yes	Yes	0	9	0	1
L:L:P32	R:R:G78	4.06	1	Yes	No	0	5	0	1
L:L:P32	R:R:W79	5.4	1	Yes	Yes	0	6	0	1
L:L:?33	R:R:D77	3.36	1	Yes	Yes	0	9	0	1
L:L:?33	R:R:S129	7.43	1	Yes	Yes	0	7	0	1
L:L:?33	R:R:Y131	5.8	1	Yes	Yes	0	5	0	1
R:R:P38	R:R:Y41	15.3	0	No	Yes	5	3	2	1
R:R:L40	R:R:P100	3.28	2	No	Yes	5	4	1	1
R:R:L40	R:R:S292	6.01	2	No	No	5	4	1	2
R:R:P100	R:R:Y41	8.34	2	Yes	Yes	4	3	1	1
R:R:M48	R:R:W79	4.65	0	No	Yes	6	6	2	1
R:R:G78	R:R:W76	8.44	1	No	Yes	5	8	1	2
R:R:D77	R:R:G78	3.35	1	Yes	No	9	5	1	1
R:R:D77	R:R:W82	6.7	1	Yes	Yes	9	9	1	2
R:R:D77	R:R:K110	5.53	1	Yes	Yes	9	8	1	2
R:R:D77	R:R:Y131	8.05	1	Yes	Yes	9	5	1	1
R:R:F99	R:R:W79	8.02	12	No	Yes	5	6	1	1
R:R:W79	R:R:Y131	19.29	0	Yes	Yes	6	5	1	1
R:R:K110	R:R:W82	31.33	1	Yes	Yes	8	9	2	2
R:R:S129	R:R:W82	3.71	1	Yes	Yes	7	9	1	2
R:R:F102	R:R:F99	10.72	12	Yes	No	4	5	1	1
R:R:D101	R:R:P100	3.22	0	No	Yes	4	4	1	1
R:R:D101	R:R:N135	5.39	0	No	Yes	4	3	1	1
R:R:C134	R:R:F102	8.38	0	No	Yes	9	4	2	1
R:R:F102	R:R:N135	4.83	12	Yes	Yes	4	3	1	1
R:R:K110	R:R:S129	13.77	1	Yes	Yes	8	7	2	1
R:R:H121	R:R:W128	33.85	0	No	Yes	4	5	2	1
R:R:N124	R:R:W128	7.91	0	No	Yes	5	5	2	1
R:R:S129	R:R:Y131	8.9	1	Yes	Yes	7	5	1	1
R:R:N135	R:R:T138	10.24	0	Yes	No	3	2	1	2
R:R:L142	R:R:Y146	4.69	0	No	Yes	2	2	1	1
R:R:Y146	R:R:Y150	3.97	3	Yes	No	2	4	1	2
R:R:L148	R:R:Y374	7.03	0	No	Yes	5	6	1	2
R:R:H377	R:R:L148	14.14	0	No	No	7	5	1	1
R:R:Y149	R:R:Y150	3.97	3	Yes	No	5	4	1	2
R:R:I153	R:R:Y149	6.04	0	No	Yes	7	5	2	1
R:R:L202	R:R:Y149	5.86	0	No	Yes	7	5	2	1
R:R:H156	R:R:I198	7.95	0	Yes	Yes	7	7	2	1
R:R:H156	R:R:H381	10.75	0	Yes	No	7	9	2	2
R:R:I198	R:R:N194	8.5	0	Yes	No	7	8	1	2
R:R:H226	R:R:I198	5.3	0	No	Yes	6	7	2	1
R:R:H201	R:R:V205	6.92	2	No	Yes	6	7	2	2
R:R:H201	R:R:L291	6.43	2	No	Yes	6	6	2	1
R:R:L291	R:R:V205	4.47	2	Yes	Yes	6	7	1	2
R:R:P207	R:R:V206	3.53	0	No	No	3	3	2	1
R:R:G209	R:R:R213	4.5	2	No	No	3	2	1	1
R:R:H226	R:R:Q227	4.95	0	No	Yes	6	7	2	2
R:R:M230	R:R:Q227	5.44	11	No	Yes	6	7	2	2
R:R:H302	R:R:Q227	4.95	11	Yes	Yes	6	7	1	2
R:R:M230	R:R:Y234	7.18	11	No	Yes	6	7	2	2
R:R:H302	R:R:M230	5.25	11	Yes	No	6	6	1	2
R:R:F356	R:R:Y234	6.19	0	Yes	Yes	7	7	1	2
R:R:H296	R:R:Y299	5.44	0	No	No	2	7	2	1
R:R:H302	R:R:L298	6.43	11	Yes	No	6	6	1	2
R:R:F356	R:R:L309	8.53	0	Yes	No	7	7	1	2
R:R:F356	R:R:Q355	11.71	0	Yes	Yes	7	8	1	2
R:R:F356	R:R:I380	6.28	0	Yes	No	7	6	1	2
R:R:F359	R:R:Y372	5.16	0	No	Yes	6	7	2	1
R:R:G369	R:R:R362	4.5	0	No	Yes	4	4	2	1
R:R:R362	R:R:Y372	8.23	10	Yes	Yes	4	7	1	1
R:R:D373	R:R:R362	13.1	10	No	Yes	5	4	2	1
R:R:P363	R:R:Y372	6.95	0	No	Yes	7	7	2	1
R:R:D373	R:R:Y372	3.45	10	No	Yes	5	7	2	1
R:R:H377	R:R:H381	9.55	0	No	No	7	9	1	2
L:L:T13	R:R:L291	2.95	0	No	Yes	0	6	0	1
L:L:I27	R:R:N135	2.83	0	No	Yes	0	3	0	1
L:L:P23	R:R:Y41	2.78	0	No	Yes	0	3	0	1
L:L:F16	R:R:A145	2.77	3	Yes	No	0	4	0	1
L:L:Q14	R:R:E294	2.55	0	Yes	No	0	3	0	1
R:R:V203	R:R:Y149	2.52	0	No	Yes	3	5	2	1
L:L:Q24	R:R:N135	1.32	0	No	Yes	0	3	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7TYH_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.22
Number of Linked Nodes	464
Number of Links	526
Number of Hubs	74
Number of Links mediated by Hubs	277
Number of Communities	16
Number of Nodes involved in Communities	84
Number of Links involved in Communities	110

Path Summary
Number Of Nodes in MetaPath	62
Number Of Links MetaPath	61
Number of Shortest Paths	196546
Length Of Smallest Path	3
Average Path Length	18.8462
Length of Longest Path	40
Minimum Path Strength	1.225
Average Path Strength	6.7636
Maximum Path Strength	27.165
Minimum Path Correlation	0.7
Average Path Correlation	0.966529
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.84615
Average % Of Corr. Nodes	57.9681
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	43.1053
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • biological regulation • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of biological process • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • localization • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • cell-cell signaling • regulation of protein transport • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • molecular transducer activity • coreceptor activity • signaling receptor activity • calcitonin family binding • amide binding • adrenomedullin binding • peptide hormone binding • hormone binding • calcitonin family receptor activity • peptide receptor activity • adrenomedullin receptor activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • transmembrane signaling receptor activity • heart development • circulatory system development • circulatory system process • regulation of blood pressure • regulation of biological quality • blood circulation • localization • import into cell • receptor internalization • transport • receptor-mediated endocytosis • endocytosis • establishment of localization • vesicle-mediated transport • blood vessel morphogenesis • tube development • angiogenesis • vasculature development • anatomical structure morphogenesis • tube morphogenesis • anatomical structure formation involved in morphogenesis • blood vessel development • regulation of biosynthetic process • positive regulation of biological process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • positive regulation of macromolecule biosynthetic process • regulation of gene expression • positive regulation of metabolic process • biosynthetic process • positive regulation of gene expression • positive regulation of biosynthetic process • regulation of macromolecule biosynthetic process • metabolic process • positive regulation of macromolecule metabolic process • macromolecule metabolic process • regulation of metabolic process • positive regulation of cellular process • regulation of developmental process • cellular developmental process • regulation of vasculogenesis • regulation of cell differentiation • vasculogenesis • positive regulation of developmental process • positive regulation of cell differentiation • cell differentiation • positive regulation of vasculogenesis • establishment of protein localization • nitrogen compound transport • protein transport • macromolecule localization • intracellular protein localization • smooth muscle cell differentiation • cell development • muscle cell differentiation • muscle structure development • vascular associated smooth muscle cell differentiation • muscle cell development • vascular associated smooth muscle cell development • protein localization to cell periphery • cellular localization • protein localization to plasma membrane • localization within membrane • protein localization to membrane • sprouting angiogenesis • negative regulation of vascular permeability • regulation of vascular permeability • vascular process in circulatory system • bicellular tight junction assembly • tight junction organization • apical junction assembly • cellular component organization • cellular component biogenesis • cell junction organization • cellular component assembly • cell junction assembly • tight junction assembly • cellular component organization or biogenesis • cell-cell junction assembly • cell-cell junction organization • intracellular transport • establishment of localization in cell • intracellular protein transport • regulation of signaling • regulation of signal transduction • regulation of response to stimulus • regulation of cell communication • regulation of G protein-coupled receptor signaling pathway • adrenomedullin receptor signaling pathway • calcitonin family receptor signaling pathway • regulation of vasculature development • regulation of multicellular organismal process • regulation of anatomical structure morphogenesis • regulation of multicellular organismal development • positive regulation of angiogenesis • positive regulation of vasculature development • regulation of angiogenesis • positive regulation of multicellular organismal process • extracellular matrix organization • basement membrane assembly • extracellular matrix assembly • basement membrane organization • extracellular structure organization • external encapsulating structure organization • amylin receptor signaling pathway • amylin receptor 2 signaling pathway • monoatomic ion transport • monoatomic cation transport • calcium ion transport • metal ion transport • negative regulation of endothelial cell apoptotic process • negative regulation of programmed cell death • regulation of apoptotic process • negative regulation of biological process • regulation of programmed cell death • cell death • negative regulation of apoptotic process • negative regulation of cellular process • endothelial cell apoptotic process • apoptotic process • programmed cell death • regulation of endothelial cell apoptotic process • adherens junction organization • adherens junction assembly • cellular response to growth factor stimulus • cellular response to vascular endothelial growth factor stimulus • response to growth factor • clathrin-coated pit • cell surface • receptor complex • G protein-coupled receptor dimeric complex • adrenomedullin receptor complex • plasma membrane signaling receptor complex • G protein-coupled receptor complex • calcitonin family receptor complex • hormone activity • molecular function activator activity • signaling receptor binding • molecular function regulator activity • signaling receptor regulator activity • receptor ligand activity • signaling receptor activator activity • calcitonin receptor binding • G protein-coupled receptor binding • identical protein binding • RNA metabolic process • regulation of primary metabolic process • negative regulation of RNA biosynthetic process • RNA biosynthetic process • nucleobase-containing compound metabolic process • DNA-templated transcription • nucleic acid biosynthetic process • regulation of RNA metabolic process • negative regulation of nucleobase-containing compound metabolic process • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • negative regulation of macromolecule metabolic process • negative regulation of DNA-templated transcription • negative regulation of metabolic process • primary metabolic process • nucleobase-containing compound biosynthetic process • nucleic acid metabolic process • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • regulation of DNA-templated transcription • negative regulation of RNA metabolic process • positive regulation of cytosolic calcium ion concentration • inorganic ion homeostasis • intracellular calcium ion homeostasis • homeostatic process • calcium ion homeostasis • regulation of cytosolic calcium ion concentration • cellular homeostasis • chemical homeostasis • intracellular monoatomic cation homeostasis • monoatomic ion homeostasis • intracellular chemical homeostasis • monoatomic cation homeostasis • intracellular monoatomic ion homeostasis • cellular response to nerve growth factor stimulus • response to nerve growth factor • regulation of protein modification process • positive regulation of phosphorylation • regulation of catalytic activity • regulation of protein phosphorylation • positive regulation of protein metabolic process • regulation of transferase activity • positive regulation of phosphate metabolic process • positive regulation of molecular function • positive regulation of protein modification process • phosphate-containing compound metabolic process • protein metabolic process • positive regulation of protein kinase activity • phosphorus metabolic process • protein modification process • positive regulation of protein phosphorylation • protein phosphorylation • positive regulation of phosphorus metabolic process • phosphorylation • regulation of protein metabolic process • positive regulation of catalytic activity • regulation of protein kinase activity • regulation of molecular function • positive regulation of kinase activity • regulation of kinase activity • activation of protein kinase activity • macromolecule modification • regulation of phosphorylation • regulation of phosphorus metabolic process • multi-multicellular organism process • reproductive process • female pregnancy • embryo implantation • multi-organism reproductive process • regulation of tube diameter • regulation of tube size • blood vessel diameter maintenance • vasodilation • regulation of anatomical structure size • response to peptide • cellular response to tumor necrosis factor • response to cytokine • cellular response to cytokine stimulus • response to tumor necrosis factor • negative regulation of tissue remodeling • negative regulation of bone remodeling • regulation of bone remodeling • tissue homeostasis • regulation of tissue remodeling • regulation of bone resorption • bone resorption • negative regulation of bone resorption • multicellular organismal-level homeostasis • tissue remodeling • bone remodeling • anatomical structure homeostasis • negative regulation of multicellular organismal process • cell chemotaxis • chemotaxis • response to external stimulus • monocyte chemotaxis • leukocyte migration • taxis • immune system process • mononuclear cell migration • myeloid leukocyte migration • cell migration • cell motility • leukocyte chemotaxis • locomotion • regulation of system process • muscle contraction • muscle system process • regulation of muscle system process • negative regulation of muscle contraction • smooth muscle contraction • regulation of smooth muscle contraction • regulation of muscle contraction • negative regulation of smooth muscle contraction • negative regulation of blood pressure • dense core granule • intracellular vesicle • cytoplasmic vesicle • secretory granule • secretory vesicle • neuronal dense core vesicle • neuron to neuron synapse • hippocampal mossy fiber to CA3 synapse • somatodendritic compartment • cell body • neuronal cell body • axon • amyloid-beta binding • peptide binding • calcitonin receptor activity • amylin receptor activity • calcitonin gene-related peptide receptor activity • calcitonin binding • positive regulation of cell communication • positive regulation of signal transduction • positive regulation of response to stimulus • regulation of intracellular signal transduction • regulation of calcium-mediated signaling • positive regulation of calcium-mediated signaling • positive regulation of intracellular signal transduction • calcium-mediated signaling • positive regulation of signaling • catabolic process • macromolecule catabolic process • post-transcriptional regulation of gene expression • regulation of mRNA catabolic process • RNA catabolic process • mRNA catabolic process • regulation of catabolic process • mRNA metabolic process • nucleobase-containing compound catabolic process • regulation of mRNA stability • negative regulation of gene expression • regulation of RNA stability • nucleic acid catabolic process • regulation of mRNA metabolic process • positive regulation of ERK1 and ERK2 cascade • positive regulation of MAPK cascade • regulation of MAPK cascade • MAPK cascade • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • amylin receptor 1 signaling pathway • regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • phosphatidylinositol 3-kinase/protein kinase B signal transduction • response to corticosteroid • response to steroid hormone • response to glucocorticoid • response to amyloid-beta • cell surface receptor signaling pathway • calcitonin gene-related peptide receptor signaling pathway • ossification • myeloid leukocyte differentiation • hemopoiesis • myeloid cell differentiation • osteoclast differentiation • leukocyte differentiation • positive regulation of cAMP/PKA signal transduction • cAMP/PKA signal transduction • regulation of cAMP/PKA signal transduction • regulation of ossification • negative regulation of ossification • amylin receptor 3 signaling pathway • amylin receptor complex • amylin receptor complex 3 • amylin receptor complex 2 • amylin receptor complex 1 • acrosomal vesicle
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • RAMP1-like • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • RAMP1-like • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	NH2
PDB Residues	L:L:?33
Environment Details	Open EMBL-EBI Page
Code	NH2
Name	AMINO GROUP
Synonyms
Identifier
Formula	H2 N
Molecular Weight	16.023
SMILES
PubChem	123329
Formal Charge	0
Total Atoms	3
Total Chiral Atoms	0
Total Bonds	2
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	E
Protein	RAMP2
UniProt	O60895
Sequence	>7TYH_nogp_Chain_E N Y E T A V Q F C W N H Y K D Q M D P I E K D W C D W A M I S R P Y S T L R D C L E H F A E L F D L G F P N P L A E R I I F E T H Q I H F A N C S D V L L A M I I A P I C L I P F L I T L V V W R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	R
Protein	Receptor
UniProt	P30988
Sequence	>7TYH_nogp_Chain_R K P F L Y V V G R K K M M D A Q Y K C Y D R M Q Q L P A Y Q G E G P Y C N R T W D G W L C W D D T P A G V L S Y Q F C P D Y F P D F D P S E K V T K Y C D E K G V W F K H P E N N R T W S N Y T M C N A F T P E K L K N A Y V L Y Y L A I V G H S L S I F T L V I S L G I F V F F R S L G C Q R V T L H K N M F L T Y I L N S M I I I I H L V E V V P N G E L V R R D P V S C K I L H F F H Q Y M M A C N Y F W M L C E G I Y L H T L I V V A V F T E K Q R L R W Y Y L L G W G F P L V P T T I H A I T R A V Y F N D N C W L S V E T H L L Y I I H G P V M A A L V V N F F F L L N I V R V L V T K M R E T H E A E S H M Y L K A V K A T M I L V P L L G I Q F V V F P W R P S N K M L G K I Y D Y V M H S L I H F Q G F F V A T I Y C F C N N E V Q T T V K R Q Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7TYH	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Calcitonin-1	-	Gs/β1/γ2; RAMP2	3.3	2022-03-23	doi.org/10.1126/science.abm9609
	7TYH (No Gprot)	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Calcitonin-1	-		3.3	2022-03-23	doi.org/10.1126/science.abm9609
	7TYY	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Calcitonin-1	-	Gs/β1/γ2; RAMP2	3	2022-03-23	doi.org/10.1126/science.abm9609
	7TYY (No Gprot)	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Calcitonin-1	-		3	2022-03-23	doi.org/10.1126/science.abm9609
	7TYX	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Amylin	-	Gs/β1/γ2; RAMP2	2.55	2022-03-30	doi.org/10.1126/science.abm9609
	7TYX (No Gprot)	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Amylin	-		2.55	2022-03-30	doi.org/10.1126/science.abm9609
	9BQ3	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Cagrilintide	-	Gs/β1/γ2; RAMP2	2.8	2025-04-23	To be published
	9BQ3 (No Gprot)	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Cagrilintide	-		2.8	2025-04-23	To be published

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