psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:C1	L:L:C7	7.28	No	No	0	0	0
2	L:L:C1	R:R:L298	4.76	No	No	4	0	6
3	L:L:C1	R:R:H302	7.37	No	Yes	4	0	6
4	L:L:S2	R:R:Y299	7.63	No	No	0	0	7
5	L:L:N3	R:R:W361	12.43	No	No	0	0	4
6	L:L:L4	R:R:W361	4.56	No	No	0	0	4
7	L:L:S5	R:R:Y372	5.09	No	Yes	0	0	7
8	L:L:T6	R:R:H302	12.32	No	Yes	0	0	6
9	L:L:V8	R:R:H377	6.92	No	Yes	0	0	7
10	L:L:L9	R:R:I198	7.14	No	Yes	0	0	7
11	L:L:G10	R:R:V293	5.52	No	No	0	0	6
12	L:L:E15	L:L:K11	4.05	No	No	0	0	0
13	L:L:K11	R:R:R362	9.9	No	No	0	0	4
14	L:L:L12	R:R:L148	5.54	No	No	2	0	5
15	L:L:L12	R:R:H377	6.43	No	Yes	2	0	7
16	L:L:S13	R:R:H201	5.58	No	No	0	0	6
17	L:L:K18	L:L:Q14	6.78	No	No	0	0	0
18	L:L:Q14	R:R:V293	5.73	No	No	0	0	6
19	L:L:Q14	R:R:E294	8.92	No	No	0	0	3
20	L:L:E15	R:R:A145	4.53	No	No	0	0	4
21	L:L:L16	R:R:Y149	3.52	No	Yes	0	0	5
22	L:L:H17	R:R:L291	7.71	No	No	0	0	6
23	R:R:P139	R:R:T138	3.5	No	No	0	3	2
24	R:R:K141	R:R:T138	7.51	No	No	0	3	2
25	R:R:L142	R:R:Y146	4.69	No	No	0	2	2
26	R:R:K370	R:R:N144	4.2	No	No	2	4	4
27	R:R:N144	R:R:Y374	3.49	No	No	2	4	6
28	R:R:H377	R:R:L148	11.57	Yes	No	2	7	5
29	R:R:I153	R:R:Y149	7.25	No	Yes	0	7	5
30	R:R:L202	R:R:Y149	7.03	No	Yes	0	7	5
31	R:R:A152	R:R:H381	4.39	No	Yes	0	7	9
32	R:R:F382	R:R:G155	6.02	No	No	0	7	8
33	R:R:H156	R:R:S195	6.97	No	No	0	7	7
34	R:R:H156	R:R:I198	5.3	No	Yes	0	7	7
35	R:R:H156	R:R:H381	5.97	No	Yes	0	7	9
36	R:R:F382	R:R:L158	6.09	No	No	6	7	4
37	R:R:F385	R:R:L158	7.31	Yes	No	6	5	4
38	R:R:I160	R:R:I192	4.42	Yes	No	0	5	7
39	R:R:I160	R:R:S195	10.84	Yes	No	0	5	7
40	R:R:F385	R:R:T162	10.38	Yes	No	0	5	6
41	R:R:F188	R:R:L163	3.65	Yes	No	0	8	8
42	R:R:L163	R:R:Y191	7.03	No	Yes	0	8	8
43	R:R:F188	R:R:S166	7.93	Yes	No	0	8	9
44	R:R:F188	R:R:L167	8.53	Yes	No	0	8	6
45	R:R:F170	R:R:V181	9.18	Yes	No	0	8	9
46	R:R:F170	R:R:K185	4.96	Yes	No	0	8	6
47	R:R:F170	R:R:F188	6.43	Yes	Yes	0	8	8
48	R:R:C392	R:R:F170	4.19	No	Yes	0	9	8
49	R:R:R174	R:R:V171	5.23	No	No	0	7	4
50	R:R:F172	R:R:F173	9.65	No	Yes	0	2	7
51	R:R:F173	R:R:L176	3.65	Yes	No	7	7	9
52	R:R:F173	R:R:T401	3.89	Yes	No	7	7	7
53	R:R:F173	R:R:Q405	8.2	Yes	No	0	7	4
54	R:R:E397	R:R:L176	10.6	No	No	0	9	9
55	R:R:L176	R:R:T401	4.42	No	No	7	9	7
56	R:R:Q179	R:R:T182	4.25	Yes	No	0	7	5
57	R:R:Q179	R:R:Y243	5.64	Yes	Yes	0	7	8
58	R:R:K256	R:R:Q179	8.14	No	Yes	0	5	7
59	R:R:L259	R:R:Q179	7.99	No	Yes	0	5	7
60	R:R:R180	R:R:V181	3.92	No	No	0	9	9
61	R:R:H184	R:R:R180	4.51	No	No	0	9	9
62	R:R:E397	R:R:R180	3.49	No	No	0	9	9
63	R:R:L183	R:R:Y243	4.69	No	Yes	0	8	8
64	R:R:E240	R:R:H184	9.85	Yes	No	0	9	9
65	R:R:N186	R:R:W236	7.91	No	Yes	0	9	9
66	R:R:N186	R:R:Y263	11.63	No	No	0	9	5
67	R:R:M187	R:R:Y191	5.99	No	Yes	1	8	8
68	R:R:M187	R:R:W236	8.14	No	Yes	1	8	9
69	R:R:E240	R:R:M187	14.89	Yes	No	1	9	8
70	R:R:F188	R:R:V387	3.93	Yes	No	0	8	9
71	R:R:N233	R:R:T190	5.85	Yes	No	0	9	9
72	R:R:T190	R:R:W267	6.06	No	Yes	0	9	9
73	R:R:N233	R:R:Y191	9.3	Yes	Yes	1	9	8
74	R:R:M237	R:R:Y191	5.99	Yes	Yes	1	9	8
75	R:R:Q383	R:R:Y191	7.89	No	Yes	1	9	8
76	R:R:G384	R:R:Y191	4.35	No	Yes	0	9	8
77	R:R:V387	R:R:Y191	8.83	No	Yes	0	9	8
78	R:R:L193	R:R:M229	7.07	No	No	0	6	4
79	R:R:I198	R:R:N194	5.66	Yes	No	0	7	8
80	R:R:N194	R:R:N233	4.09	No	Yes	0	8	9
81	R:R:H226	R:R:I197	5.3	No	Yes	0	6	5
82	R:R:H226	R:R:I198	3.98	No	Yes	0	6	7
83	R:R:I200	R:R:L222	4.28	No	No	0	6	6
84	R:R:C219	R:R:E204	6.08	No	No	0	9	4
85	R:R:C219	R:R:C289	7.28	No	No	0	9	9
86	R:R:K220	R:R:W290	11.6	No	Yes	0	7	9
87	R:R:H223	R:R:Q227	12.36	No	Yes	0	5	7
88	R:R:H223	R:R:W290	12.7	No	Yes	0	5	9
89	R:R:F224	R:R:T274	7.78	No	No	0	5	6
90	R:R:H226	R:R:Q227	4.95	No	Yes	0	6	7
91	R:R:M230	R:R:Q227	4.08	No	Yes	0	6	7
92	R:R:I301	R:R:Q227	8.23	Yes	Yes	0	7	7
93	R:R:M229	R:R:Y228	4.79	No	Yes	0	4	8
94	R:R:W267	R:R:Y228	6.75	Yes	Yes	0	9	8
95	R:R:P270	R:R:Y228	5.56	Yes	Yes	0	9	8
96	R:R:L271	R:R:Y228	9.38	No	Yes	0	4	8
97	R:R:T274	R:R:Y228	4.99	No	Yes	0	6	8
98	R:R:M230	R:R:Y234	4.79	No	Yes	0	6	7
99	R:R:H302	R:R:M230	3.94	Yes	No	0	6	6
100	R:R:C232	R:R:W267	6.53	No	Yes	0	8	9
101	R:R:C232	R:R:P270	3.77	No	Yes	0	8	9
102	R:R:M237	R:R:N233	4.21	Yes	Yes	1	9	9
103	R:R:M237	R:R:Y234	4.79	Yes	Yes	0	9	7
104	R:R:V305	R:R:Y234	7.57	No	Yes	0	7	7
105	R:R:F356	R:R:Y234	10.32	Yes	Yes	0	7	7
106	R:R:F235	R:R:F269	8.57	No	No	0	5	3
107	R:R:F235	R:R:P270	8.67	No	Yes	0	5	9
108	R:R:E240	R:R:W236	6.54	Yes	Yes	1	9	9
109	R:R:G266	R:R:W236	4.22	No	Yes	0	9	9
110	R:R:W236	R:R:W267	9.37	Yes	Yes	0	9	9
111	R:R:M237	R:R:Q383	5.44	Yes	No	1	9	9
112	R:R:I242	R:R:L238	7.14	No	No	0	7	8
113	R:R:A308	R:R:L238	4.73	No	No	0	7	8
114	R:R:C239	R:R:L265	4.76	No	No	0	7	7
115	R:R:E240	R:R:L351	6.63	Yes	No	0	9	9
116	R:R:G241	R:R:N312	5.09	No	No	0	8	9
117	R:R:I242	R:R:Y262	6.04	No	No	0	7	7
118	R:R:F315	R:R:I242	3.77	No	No	0	8	7
119	R:R:L247	R:R:Y243	4.69	No	Yes	0	8	8
120	R:R:Y243	R:R:Y262	5.96	Yes	No	0	8	7
121	R:R:I319	R:R:L244	4.28	No	No	0	9	9
122	R:R:H245	R:R:V249	6.92	Yes	No	0	8	6
123	R:R:F315	R:R:H245	22.63	No	Yes	0	8	8
124	R:R:H245	R:R:N318	8.93	Yes	No	0	8	8
125	R:R:E255	R:R:T246	5.64	No	No	0	6	7
126	R:R:I248	R:R:I319	5.89	No	No	0	7	9
127	R:R:K256	R:R:T254	4.5	No	No	0	5	6
128	R:R:E255	R:R:R258	5.82	No	No	0	6	5
129	R:R:E255	R:R:Y262	7.86	No	No	0	6	7
130	R:R:R258	R:R:W261	5	No	No	0	5	2
131	R:R:L259	R:R:Y263	4.69	No	No	0	5	5
132	R:R:W267	R:R:Y263	3.86	Yes	No	0	9	5
133	R:R:F269	R:R:L265	3.65	No	No	0	3	7
134	R:R:P273	R:R:V272	5.3	No	No	0	6	4
135	R:R:H277	R:R:R281	12.41	Yes	No	0	7	7
136	R:R:H277	R:R:L298	7.71	Yes	No	0	7	6
137	R:R:H277	R:R:I300	5.3	Yes	No	0	7	8
138	R:R:H277	R:R:I301	7.95	Yes	Yes	0	7	7
139	R:R:D287	R:R:R281	11.91	Yes	No	0	3	7
140	R:R:R281	R:R:W290	16.99	No	Yes	0	7	9
141	R:R:L297	R:R:Y284	8.21	No	No	0	4	2
142	R:R:D287	R:R:F285	8.36	Yes	No	0	3	6
143	R:R:F285	R:R:T295	5.19	No	No	0	6	4
144	R:R:D287	R:R:N288	4.04	Yes	No	0	3	4
145	R:R:D287	R:R:S292	8.83	Yes	No	0	3	4
146	R:R:E294	R:R:S292	7.19	No	No	0	3	4
147	R:R:L297	R:R:T295	4.42	No	No	0	4	4
148	R:R:H296	R:R:Y299	15.24	No	No	0	2	7
149	R:R:H302	R:R:L298	3.86	Yes	No	4	6	6
150	R:R:H302	R:R:I301	3.98	Yes	Yes	0	6	7
151	R:R:G303	R:R:P304	4.06	No	No	0	4	9
152	R:R:F356	R:R:L309	4.87	Yes	No	0	7	7
153	R:R:L352	R:R:N312	8.24	Yes	No	0	9	9
154	R:R:F313	R:R:L317	6.09	No	No	0	6	5
155	R:R:F313	R:R:I354	6.28	No	Yes	0	6	6
156	R:R:F314	R:R:F315	6.43	No	No	0	5	8
157	R:R:F314	R:R:N318	9.67	No	No	0	5	8
158	R:R:L316	R:R:T345	4.42	Yes	No	0	9	9
159	R:R:L316	R:R:L348	5.54	Yes	No	3	9	9
160	R:R:L316	R:R:L352	4.15	Yes	Yes	3	9	9
161	R:R:I354	R:R:L316	4.28	Yes	Yes	3	6	9
162	R:R:M327	R:R:M337	4.33	No	No	0	7	7
163	R:R:K340	R:R:M327	10.08	No	No	0	8	7
164	R:R:M337	R:R:Y338	7.18	No	No	0	7	7
165	R:R:I347	R:R:I390	7.36	No	No	0	8	8
166	R:R:L348	R:R:L352	4.15	No	Yes	3	9	9
167	R:R:P350	R:R:V349	3.53	No	No	0	9	8
168	R:R:I354	R:R:V349	6.14	Yes	No	0	6	8
169	R:R:L351	R:R:Y391	19.93	No	No	0	9	8
170	R:R:I354	R:R:L352	5.71	Yes	Yes	3	6	9
171	R:R:G353	R:R:Q355	4.93	No	Yes	0	9	8
172	R:R:F356	R:R:Q355	14.05	Yes	Yes	0	7	8
173	R:R:Q355	R:R:Q383	11.52	Yes	No	0	8	9
174	R:R:F356	R:R:I380	7.54	Yes	No	0	7	6
175	R:R:F359	R:R:V358	5.24	Yes	No	0	6	5
176	R:R:F359	R:R:Y372	5.16	Yes	Yes	5	6	7
177	R:R:F359	R:R:M376	4.98	Yes	No	5	6	7
178	R:R:R362	R:R:Y372	4.12	No	Yes	0	4	7
179	R:R:L368	R:R:P363	6.57	No	No	0	3	7
180	R:R:P363	R:R:Y372	12.52	No	Yes	0	7	7
181	R:R:M367	R:R:N365	5.61	No	No	0	4	4
182	R:R:L368	R:R:N365	4.12	No	No	0	3	4
183	R:R:K370	R:R:Y374	13.14	No	No	2	4	6
184	R:R:M376	R:R:Y372	7.18	No	Yes	5	7	7
185	R:R:D373	R:R:H377	10.08	No	Yes	0	5	7
186	R:R:H377	R:R:H381	7.17	Yes	Yes	0	7	9
187	R:R:F382	R:R:F385	6.43	No	Yes	6	7	5
188	R:R:F385	R:R:F386	7.5	Yes	No	0	5	5
189	R:R:F393	R:R:T389	3.89	No	No	0	8	5
190	R:R:E397	R:R:N395	10.52	No	No	0	9	9
191	R:R:N395	R:R:V398	5.91	No	No	0	9	9
192	R:R:K403	R:R:Q399	4.07	No	No	0	6	7
193	R:R:Q405	R:R:Q408	7.68	No	No	0	4	7
194	R:R:K410	R:R:W406	4.64	No	No	0	4	6
195	R:R:Q408	R:R:Q412	3.84	No	No	0	7	4
196	R:R:I411	R:R:Q412	8.23	No	No	0	4	4
197	R:R:A388	R:R:S166	3.42	No	No	0	8	9
198	R:R:C178	R:R:V181	3.42	No	No	0	8	9
199	R:R:A231	R:R:I301	3.25	No	Yes	0	5	7
200	R:R:T345	R:R:V320	3.17	No	No	0	9	7
201	L:L:L16	R:R:A145	3.15	No	No	0	0	4
202	R:R:I199	R:R:S195	3.1	No	No	0	7	7
203	R:R:I248	R:R:V249	3.07	No	No	0	7	6
204	R:R:I354	R:R:V357	3.07	Yes	No	0	6	7
205	R:R:I279	R:R:T275	3.04	No	No	0	3	3
206	R:R:I300	R:R:T280	3.04	No	No	0	8	4
207	R:R:K326	R:R:V322	3.04	No	No	0	9	8
208	R:R:F409	R:R:W413	3.01	No	No	0	3	3
209	R:R:L163	R:R:S159	3	No	No	0	8	9
210	L:L:L4	L:L:T6	2.95	No	No	0	0	0
211	R:R:L271	R:R:T275	2.95	No	No	0	4	3
212	R:R:I276	R:R:I300	2.94	No	No	0	5	8
213	R:R:I347	R:R:K343	2.91	No	No	0	8	8
214	R:R:F235	R:R:P304	2.89	No	No	0	5	9
215	R:R:F386	R:R:P350	2.89	No	No	0	5	9
216	R:R:Q355	R:R:V349	2.87	Yes	No	0	8	8
217	R:R:I198	R:R:L202	2.85	Yes	No	0	7	7
218	R:R:L323	R:R:M327	2.83	No	No	0	9	7
219	R:R:C392	R:R:F393	2.79	No	No	0	9	8
220	L:L:L19	R:R:L142	2.77	No	No	0	0	2
221	R:R:H201	R:R:V205	2.77	No	No	0	6	7
222	R:R:A278	R:R:F224	2.77	No	No	0	6	5
223	R:R:H245	R:R:V250	2.77	Yes	No	0	8	5
224	R:R:L148	R:R:N144	2.75	No	No	2	5	4
225	R:R:L379	R:R:Q355	2.66	No	Yes	0	5	8
226	R:R:F269	R:R:V272	2.62	No	No	0	3	4
227	R:R:A282	R:R:W290	2.59	No	Yes	0	3	9
228	R:R:H381	R:R:L151	2.57	Yes	No	0	9	5
229	R:R:H201	R:R:L291	2.57	No	No	0	6	6
230	R:R:F161	R:R:I160	2.51	No	Yes	0	4	5
231	R:R:F173	R:R:I169	2.51	Yes	No	0	7	8
232	R:R:F225	R:R:I221	2.51	No	No	0	5	4
233	R:R:M337	R:R:R328	2.48	No	No	0	7	6
234	R:R:I390	R:R:Y391	2.42	No	No	0	8	8
235	L:L:L16	R:R:Y146	2.34	No	No	0	0	2
236	R:R:L189	R:R:W267	2.28	No	Yes	0	3	9
237	R:R:G268	R:R:P270	2.03	No	Yes	0	6	9
238	R:R:G369	R:R:P363	2.03	No	No	0	4	7
239	R:R:F409	R:R:W406	2	No	No	0	3	6
240	R:R:G155	R:R:V154	1.84	No	No	0	8	6
241	R:R:G168	R:R:V171	1.84	No	No	0	1	4
242	R:R:A341	R:R:V324	1.7	No	No	0	9	5
243	R:R:C394	R:R:T389	1.69	No	No	0	5	5
244	R:R:A251	R:R:T246	1.68	No	No	0	6	7
245	R:R:V249	R:R:V322	1.6	No	No	0	6	8
246	R:R:V398	R:R:V402	1.6	No	No	0	9	5
247	R:R:C289	R:R:L291	1.59	No	No	0	9	6
248	R:R:A344	R:R:L323	1.58	No	No	0	9	9
249	R:R:T400	R:R:T401	1.57	No	No	0	4	7
250	R:R:I199	R:R:S157	1.55	No	No	0	7	7
251	R:R:I165	R:R:V164	1.54	No	No	0	5	4
252	R:R:I192	R:R:V164	1.54	No	No	0	7	4
253	R:R:I200	R:R:V203	1.54	No	No	0	6	3
254	R:R:I221	R:R:V217	1.54	No	No	0	4	3
255	R:R:I371	R:R:V375	1.54	No	No	0	5	4
256	R:R:K143	R:R:V147	1.52	No	No	0	1	4
257	L:L:L4	L:L:S2	1.5	No	No	0	0	0
258	L:L:S13	R:R:L202	1.5	No	No	0	0	7
259	R:R:K326	R:R:T325	1.5	No	No	0	9	7
260	R:R:L238	R:R:V311	1.49	No	No	0	8	6
261	R:R:I197	R:R:I200	1.47	Yes	No	0	5	6
262	R:R:I160	R:R:M196	1.46	Yes	No	0	5	4
263	R:R:I197	R:R:M196	1.46	Yes	No	0	5	4
264	R:R:I347	R:R:M346	1.46	No	No	0	8	8
265	R:R:N396	R:R:T400	1.46	No	No	0	6	4
266	R:R:F359	R:R:P360	1.44	Yes	No	0	6	5
267	R:R:I371	R:R:L368	1.43	No	No	0	5	3
268	L:L:L19	R:R:K141	1.41	No	No	0	0	3
269	R:R:K220	R:R:N286	1.4	No	No	0	7	7
270	R:R:K256	R:R:Q257	1.36	No	No	0	5	5
271	R:R:E140	R:R:K143	1.35	No	No	0	2	1
272	R:R:R328	R:R:V324	1.31	No	No	0	6	5
273	R:R:F225	R:R:I197	1.26	No	Yes	0	5	5
274	R:R:N318	R:R:R321	1.21	No	No	0	8	8
275	R:R:Y149	R:R:Y150	0.99	Yes	No	0	5	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Y149	4.6975	4	0	5
2	R:R:I160	4.8075	4	0	5
3	R:R:F170	6.19	4	0	8
4	R:R:F173	5.58	5	7	7
5	R:R:Q179	6.505	4	0	7
6	R:R:F188	6.094	5	0	8
7	R:R:Y191	7.05429	7	1	8
8	R:R:I197	2.3725	4	0	5
9	R:R:I198	4.986	5	0	7
10	R:R:Q227	7.405	4	0	7
11	R:R:Y228	6.294	5	0	8
12	R:R:N233	5.8625	4	1	9
13	R:R:Y234	6.8675	4	0	7
14	R:R:W236	7.236	5	1	9
15	R:R:M237	5.1075	4	1	9
16	R:R:E240	9.4775	4	1	9
17	R:R:Y243	5.245	4	0	8
18	R:R:H245	10.3125	4	0	8
19	R:R:W267	5.80833	6	0	9
20	R:R:P270	5.0075	4	0	9
21	R:R:H277	8.3425	4	0	7
22	R:R:D287	8.285	4	0	3
23	R:R:W290	10.97	4	0	9
24	R:R:I301	5.8525	4	0	7
25	R:R:H302	6.294	5	4	6
26	R:R:L316	4.5975	4	3	9
27	R:R:L352	5.5625	4	3	9
28	R:R:I354	5.096	5	3	6
29	R:R:Q355	7.206	5	0	8
30	R:R:F356	9.195	4	0	7
31	R:R:F359	4.205	4	5	6
32	R:R:Y372	6.814	5	5	7
33	R:R:H377	8.434	5	2	7
34	R:R:H381	5.025	4	0	9
35	R:R:F385	7.905	4	6	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:T6	R:R:H302	13.1721	12.32	No	Yes	0	0	6
2	L:L:L4	L:L:T6	11.3215	2.95	No	No	0	0	0
3	R:R:H302	R:R:M230	43.6048	3.94	Yes	No	0	6	6
4	R:R:M230	R:R:Q227	40.0255	4.08	No	Yes	0	6	7
5	R:R:H226	R:R:Q227	39.8558	4.95	No	Yes	0	6	7
6	R:R:H226	R:R:I198	41.7383	3.98	No	Yes	0	6	7
7	R:R:I198	R:R:L202	54.3165	2.85	Yes	No	0	7	7
8	R:R:L202	R:R:Y149	42.0034	7.03	No	Yes	0	7	5
9	L:L:L16	R:R:Y149	37.7081	3.52	No	Yes	0	0	5
10	L:L:L16	R:R:A145	27.3147	3.15	No	No	0	0	4
11	L:L:E15	R:R:A145	25.7875	4.53	No	No	0	0	4
12	L:L:E15	L:L:K11	24.2497	4.05	No	No	0	0	0
13	L:L:K11	R:R:R362	22.7012	9.9	No	No	0	0	4
14	R:R:R362	R:R:Y372	21.2271	4.12	No	Yes	0	4	7
15	R:R:H302	R:R:I301	21.1687	3.98	Yes	Yes	0	6	7
16	R:R:I301	R:R:Q227	34.4045	8.23	Yes	Yes	0	7	7
17	R:R:H156	R:R:I198	29.4941	5.3	No	Yes	0	7	7
18	R:R:H156	R:R:H381	17.9924	5.97	No	Yes	0	7	9
19	R:R:H377	R:R:H381	13.188	7.17	Yes	Yes	0	7	9
20	R:R:H277	R:R:L298	15.85	7.71	Yes	No	0	7	6
21	R:R:H277	R:R:R281	44.4639	12.41	Yes	No	0	7	7
22	R:R:D287	R:R:R281	59.7465	11.91	Yes	No	0	3	7
23	R:R:D287	R:R:S292	30.0615	8.83	Yes	No	0	3	4
24	R:R:E294	R:R:S292	25.0769	7.19	No	No	0	3	4
25	L:L:Q14	R:R:E294	20.0817	8.92	No	No	0	0	3
26	L:L:Q14	R:R:V293	10.0594	5.73	No	No	0	0	6
27	L:L:S13	R:R:L202	13.2729	1.5	No	No	0	0	7
28	L:L:S13	R:R:H201	11.6502	5.58	No	No	0	0	6
29	L:L:L16	R:R:Y146	10.017	2.34	No	No	0	0	2
30	R:R:M230	R:R:Y234	75.1829	4.79	No	Yes	0	6	7
31	R:R:F356	R:R:Y234	18.2999	10.32	Yes	Yes	0	7	7
32	R:R:F356	R:R:Q355	14.2592	14.05	Yes	Yes	0	7	8
33	R:R:Q355	R:R:V349	58.2034	2.87	Yes	No	0	8	8
34	R:R:P350	R:R:V349	22.8179	3.53	No	No	0	9	8
35	R:R:F386	R:R:P350	20.0021	2.89	No	No	0	5	9
36	R:R:F385	R:R:F386	17.1757	7.5	Yes	No	0	5	5
37	R:R:H156	R:R:S195	11.0616	6.97	No	No	0	7	7
38	R:R:H226	R:R:I197	14.1638	5.3	No	Yes	0	6	5
39	R:R:M237	R:R:Y234	63.2305	4.79	Yes	Yes	0	9	7
40	R:R:M237	R:R:Y191	27.7601	5.99	Yes	Yes	1	9	8
41	R:R:L163	R:R:Y191	25.4375	7.03	No	Yes	0	8	8
42	R:R:F188	R:R:L163	21.7786	3.65	Yes	No	0	8	8
43	R:R:V387	R:R:Y191	23.4595	8.83	No	Yes	0	9	8
44	R:R:F188	R:R:V387	21.6301	3.93	Yes	No	0	8	9
45	R:R:F170	R:R:F188	28.0783	6.43	Yes	Yes	0	8	8
46	R:R:C392	R:R:F170	18.4484	4.19	No	Yes	0	9	8
47	R:R:M187	R:R:Y191	56.1671	5.99	No	Yes	1	8	8
48	R:R:E240	R:R:M187	24.8118	14.89	Yes	No	1	9	8
49	R:R:E240	R:R:H184	32.172	9.85	Yes	No	0	9	9
50	R:R:H184	R:R:R180	30.6872	4.51	No	No	0	9	9
51	R:R:E397	R:R:R180	25.5011	3.49	No	No	0	9	9
52	R:R:E397	R:R:L176	18.9734	10.6	No	No	0	9	9
53	R:R:F173	R:R:L176	12.0957	3.65	Yes	No	7	7	9
54	R:R:M237	R:R:N233	52.3969	4.21	Yes	Yes	1	9	9
55	R:R:N233	R:R:T190	100	5.85	Yes	No	0	9	9
56	R:R:T190	R:R:W267	99.0402	6.06	No	Yes	0	9	9
57	R:R:W267	R:R:Y263	72.9664	3.86	Yes	No	0	9	5
58	R:R:L259	R:R:Y263	85.9953	4.69	No	No	0	5	5
59	R:R:L259	R:R:Q179	83.6197	7.99	No	Yes	0	5	7
60	R:R:Q179	R:R:Y243	71.7202	5.64	Yes	Yes	0	7	8
61	R:R:M187	R:R:W236	30.91	8.14	No	Yes	1	8	9
62	R:R:N186	R:R:W236	17.584	7.91	No	Yes	0	9	9
63	R:R:M237	R:R:Q383	17.5894	5.44	Yes	No	1	9	9
64	R:R:W267	R:R:Y228	40.1103	6.75	Yes	Yes	0	9	8
65	R:R:I198	R:R:N194	77.8237	5.66	Yes	No	0	7	8
66	R:R:N194	R:R:N233	78.1896	4.09	No	Yes	0	8	9
67	R:R:R281	R:R:W290	21.3013	16.99	No	Yes	0	7	9
68	R:R:H223	R:R:Q227	28.7835	12.36	No	Yes	0	5	7
69	R:R:P270	R:R:Y228	21.5452	5.56	Yes	Yes	0	9	8
70	R:R:C232	R:R:W267	23.1891	6.53	No	Yes	0	8	9
71	R:R:C232	R:R:P270	21.1263	3.77	No	Yes	0	8	9
72	R:R:F235	R:R:P270	34.0969	8.67	No	Yes	0	5	9
73	R:R:F235	R:R:F269	21.5505	8.57	No	No	0	5	3
74	R:R:Y243	R:R:Y262	64.4713	5.96	Yes	No	0	8	7
75	R:R:I242	R:R:Y262	49.5546	6.04	No	No	0	7	7
76	R:R:E240	R:R:L351	10.5738	6.63	Yes	No	0	9	9
77	R:R:I354	R:R:V349	33.7204	6.14	Yes	No	0	6	8
78	R:R:I354	R:R:L352	11.4063	5.71	Yes	Yes	3	6	9
79	R:R:F315	R:R:I242	39.405	3.77	No	No	0	8	7
80	R:R:F315	R:R:H245	28.9479	22.63	No	Yes	0	8	8
81	R:R:H245	R:R:V249	18.5279	6.92	Yes	No	0	8	6
82	R:R:E255	R:R:Y262	13.4532	7.86	No	No	0	6	7
83	R:R:H277	R:R:I300	10.3829	5.3	Yes	No	0	7	8
84	R:R:D287	R:R:F285	20.0817	8.36	Yes	No	0	3	6
85	R:R:F285	R:R:T295	15.0758	5.19	No	No	0	6	4
86	R:R:L297	R:R:T295	10.0594	4.42	No	No	0	4	4
87	R:R:I354	R:R:L316	11.1465	4.28	Yes	Yes	3	6	9
88	R:R:P363	R:R:Y372	11.6502	12.52	No	Yes	0	7	7
89	R:R:C392	R:R:F393	13.8509	2.79	No	No	0	9	8
90	R:R:H302	R:R:L298	16.7674	3.86	Yes	No	4	6	6
91	R:R:H277	R:R:I301	42.4382	7.95	Yes	Yes	0	7	7
92	R:R:H223	R:R:W290	27.1768	12.7	No	Yes	0	5	9
93	R:R:N233	R:R:Y191	46.7653	9.3	Yes	Yes	1	9	8
94	R:R:Q383	R:R:Y191	38.8323	7.89	No	Yes	1	9	8
95	R:R:Q355	R:R:Q383	53.7544	11.52	Yes	No	0	8	9
96	R:R:W236	R:R:W267	31.4614	9.37	Yes	Yes	0	9	9
97	R:R:N186	R:R:Y263	16.428	11.63	No	No	0	9	5
98	R:R:E240	R:R:W236	17.8386	6.54	Yes	Yes	1	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:C1	R:R:L298	4.76	4	No	No	0	6	0	1
L:L:C1	R:R:H302	7.37	4	No	Yes	0	6	0	1
L:L:S2	R:R:Y299	7.63	0	No	No	0	7	0	1
L:L:N3	R:R:W361	12.43	0	No	No	0	4	0	1
L:L:L4	R:R:W361	4.56	0	No	No	0	4	0	1
L:L:S5	R:R:Y372	5.09	0	No	Yes	0	7	0	1
L:L:T6	R:R:H302	12.32	0	No	Yes	0	6	0	1
L:L:V8	R:R:H377	6.92	0	No	Yes	0	7	0	1
L:L:L9	R:R:I198	7.14	0	No	Yes	0	7	0	1
L:L:G10	R:R:V293	5.52	0	No	No	0	6	0	1
L:L:K11	R:R:R362	9.9	0	No	No	0	4	0	1
L:L:L12	R:R:L148	5.54	2	No	No	0	5	0	1
L:L:L12	R:R:H377	6.43	2	No	Yes	0	7	0	1
L:L:S13	R:R:H201	5.58	0	No	No	0	6	0	1
L:L:Q14	R:R:V293	5.73	0	No	No	0	6	0	1
L:L:Q14	R:R:E294	8.92	0	No	No	0	3	0	1
L:L:E15	R:R:A145	4.53	0	No	No	0	4	0	1
L:L:L16	R:R:Y149	3.52	0	No	Yes	0	5	0	1
L:L:H17	R:R:L291	7.71	0	No	No	0	6	0	1
R:R:K141	R:R:T138	7.51	0	No	No	3	2	1	2
R:R:L142	R:R:Y146	4.69	0	No	No	2	2	1	1
R:R:H377	R:R:L148	11.57	2	Yes	No	7	5	1	1
R:R:I153	R:R:Y149	7.25	0	No	Yes	7	5	2	1
R:R:L202	R:R:Y149	7.03	0	No	Yes	7	5	1	1
R:R:H156	R:R:I198	5.3	0	No	Yes	7	7	2	1
R:R:H156	R:R:H381	5.97	0	No	Yes	7	9	2	2
R:R:I198	R:R:N194	5.66	0	Yes	No	7	8	1	2
R:R:H226	R:R:I198	3.98	0	No	Yes	6	7	2	1
R:R:H302	R:R:M230	3.94	4	Yes	No	6	6	1	2
R:R:H277	R:R:L298	7.71	0	Yes	No	7	6	2	1
R:R:H277	R:R:I301	7.95	0	Yes	Yes	7	7	2	2
R:R:E294	R:R:S292	7.19	0	No	No	3	4	1	2
R:R:H296	R:R:Y299	15.24	0	No	No	2	7	2	1
R:R:H302	R:R:L298	3.86	4	Yes	No	6	6	1	1
R:R:H302	R:R:I301	3.98	4	Yes	Yes	6	7	1	2
R:R:F359	R:R:Y372	5.16	5	Yes	Yes	6	7	2	1
R:R:F359	R:R:M376	4.98	5	Yes	No	6	7	2	2
R:R:R362	R:R:Y372	4.12	0	No	Yes	4	7	1	1
R:R:P363	R:R:Y372	12.52	0	No	Yes	7	7	2	1
R:R:M376	R:R:Y372	7.18	5	No	Yes	7	7	2	1
R:R:D373	R:R:H377	10.08	0	No	Yes	5	7	2	1
R:R:H377	R:R:H381	7.17	2	Yes	Yes	7	9	1	2
L:L:L16	R:R:A145	3.15	0	No	No	0	4	0	1
R:R:I198	R:R:L202	2.85	0	Yes	No	7	7	1	1
L:L:L19	R:R:L142	2.77	0	No	No	0	2	0	1
R:R:H201	R:R:V205	2.77	0	No	No	6	7	1	2
R:R:L148	R:R:N144	2.75	2	No	No	5	4	1	2
R:R:H201	R:R:L291	2.57	0	No	No	6	6	1	1
L:L:L16	R:R:Y146	2.34	0	No	No	0	2	0	1
R:R:C289	R:R:L291	1.59	0	No	No	9	6	2	1
L:L:S13	R:R:L202	1.5	0	No	No	0	7	0	1
L:L:L19	R:R:K141	1.41	0	No	No	0	3	0	1
R:R:Y149	R:R:Y150	0.99	0	Yes	No	5	4	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	6NIY_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.49
Number of Linked Nodes	258
Number of Links	275
Number of Hubs	35
Number of Links mediated by Hubs	135
Number of Communities	7
Number of Nodes involved in Communities	29
Number of Links involved in Communities	33

Path Summary
Number Of Nodes in MetaPath	99
Number Of Links MetaPath	98
Number of Shortest Paths	56082
Length Of Smallest Path	3
Average Path Length	13.5653
Length of Longest Path	29
Minimum Path Strength	1.36
Average Path Strength	6.33783
Maximum Path Strength	15.78
Minimum Path Correlation	0.7
Average Path Correlation	0.939494
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	4.34783
Average % Of Corr. Nodes	54.9386
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	43.0526
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	L
Protein	Calcitonin-1
UniProt	Q92163
Sequence	>6NIY_nogp_Chain_L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	R
Protein	Receptor
UniProt	P30988
Sequence	>6NIY_nogp_Chain_R T P E K L K N A Y V L Y Y L A I V G H S L S I F T L V I S L G I F V F F R S L G C Q R V T L H K N M F L T Y I L N S M I I I I H L V E V V S C K I L H F F H Q Y M M A C N Y F W M L C E G I Y L H T L I V V A V F T E K Q R L R W Y Y L L G W G F P L V P T T I H A I T R A V Y F N D N C W L S V E T H L L Y I I H G P V M A A L V V N F F F L L N I V R V L V T K M R E T H M Y L K A V K A T M I L V P L L G I Q F V V F P W R P S N K M L G K I Y D Y V M H S L I H F Q G F F V A T I Y C F C N N E V Q T T V K R Q W A Q F K I Q W N Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	3DQB	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	Gt(CT)	3.2	2008-09-23	doi.org/10.1038/nature07330
	3PQR	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gt(CT)	2.85	2011-03-09	doi.org/10.1038/nature09789
	2X72	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gt(CT)	3	2011-03-16	doi.org/10.1038/nature09795
	4A4M	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gt(CT)	3.3	2012-01-25	doi.org/10.1073/pnas.1114089108
	4BEY	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	Gt(CT)	2.9	2013-05-08	doi.org/10.1038/embor.2013.44
	4J4Q	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl β-D-Glucopyranoside	-	Gt(CT)	2.65	2013-10-30	doi.org/10.1002/anie.201302374
	4X1H	A	Sensory	Opsins	Rhodopsin	Bos taurus	Nonyl-β-D-Glucopyranoside	-	Gt(CT)	2.29	2015-11-04	doi.org/10.1016/j.str.2015.09.015
	5EN0	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gt(CT)	2.81	2016-08-10	doi.org/10.15252/embr.201642671
	5UZ7	B1	Peptide	Calcitonin	CT	Homo sapiens	-	-	Gs/β1/γ2	4.1	2017-05-03	doi.org/10.1038/nature22327
	5UZ7 (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	-	-		4.1	2017-05-03	doi.org/10.1038/nature22327
	5WKT	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl-β-D-Glucopyranoside	-	Gt(CT)	3.2	2017-12-13	doi.org/10.1038/nprot.2017.135
	6E3Y	B1	Peptide	Calcitonin	CT Like	Homo sapiens	Calcitonin gene-related peptide-1	-	Gs/β1/γ2; RAMP1	3.3	2018-09-19	doi.org/10.1038/s41586-018-0535-y
	6E3Y (No Gprot)	B1	Peptide	Calcitonin	CT Like	Homo sapiens	Calcitonin gene-related peptide-1	-		3.3	2018-09-19	doi.org/10.1038/s41586-018-0535-y
	6NIY	B1	Peptide	Calcitonin	CT	Homo sapiens	Calcitonin-1	-	Gs/β1/γ2	3.34	2019-01-23	doi.org/10.1021/acsptsci.8b00056
	6NIY (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	Calcitonin-1	-		3.34	2019-01-23	doi.org/10.1021/acsptsci.8b00056
	6E67	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	-	Gs(CT)	3.7	2019-06-05	doi.org/10.1016/j.cell.2019.04.021
	6TP4	A	Peptide	Orexin	OX₁	Homo sapiens	ACT-462206	-	-	3.01	2020-01-01	doi.org/10.1021/acs.jmedchem.9b01787
	6NWE	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl-β-D-Glucopyranoside	-	Gt(CT)	2.71	2020-02-12	To be published
	6UUN	B1	Peptide	Calcitonin	CT Like (AM1)	Homo sapiens	Adrenomedullin	-	Gs/β1/γ2; RAMP2	3	2020-03-25	doi.org/10.1021/acsptsci.9b00080
	6UUN (No Gprot)	B1	Peptide	Calcitonin	CT Like (AM1)	Homo sapiens	Adrenomedullin	-		3	2020-03-25	doi.org/10.1021/acsptsci.9b00080
	6UUS	B1	Peptide	Calcitonin	CT Like (AM2)	Homo sapiens	Adrenomedullin	-	Gs/β1/γ2; RAMP3	2.4	2020-04-01	doi.org/10.1021/acsptsci.9b00080
	6UUS (No Gprot)	B1	Peptide	Calcitonin	CT Like (AM2)	Homo sapiens	Adrenomedullin	-		2.4	2020-04-01	doi.org/10.1021/acsptsci.9b00080
	6UVA	B1	Peptide	Calcitonin	CT Like (AM2)	Homo sapiens	Adrenomedullin-2	-	Gs/β1/γ2; RAMP3	2.3	2020-04-01	doi.org/10.1021/acsptsci.9b00080
	6UVA (No Gprot)	B1	Peptide	Calcitonin	CT Like (AM2)	Homo sapiens	Adrenomedullin-2	-		2.3	2020-04-01	doi.org/10.1021/acsptsci.9b00080
	6PEL	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	Citronellol	Gt(CT)	3.19	2020-06-24	To be published
	6PGS	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	Geraniol	Gt(CT)	2.9	2020-07-01	To be published
	6PH7	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	Nerol	Gt(CT)	2.9	2020-07-01	To be published
	7KNT	B1	Peptide	Calcitonin	CT Like	Homo sapiens	-	-	RAMP1	3.15	2021-02-24	doi.org/10.1126/science.abf7258
	7KNU	B1	Peptide	Calcitonin	CT Like	Homo sapiens	Calcitonin gene-related peptide-1	-	RAMP1	3.49	2021-02-24	doi.org/10.1126/science.abf7258
	7TYL	B1	Peptide	Calcitonin	CT	Homo sapiens	Amylin	-	Gs/β1/γ2	3.3	2022-03-23	doi.org/10.1126/science.abm9609
	7TYL (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	Amylin	-		3.3	2022-03-23	doi.org/10.1126/science.abm9609
	7TYO	B1	Peptide	Calcitonin	CT	Homo sapiens	Calcitonin	-	Gs/β1/γ2	2.7	2022-03-23	doi.org/10.1126/science.abm9609
	7TYO (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	Calcitonin	-		2.7	2022-03-23	doi.org/10.1126/science.abm9609
	7TYF	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Amylin	-	Gs/β1/γ2; RAMP1	2.2	2022-03-23	doi.org/10.1126/science.abm9609
	7TYF (No Gprot)	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Amylin	-		2.2	2022-03-23	doi.org/10.1126/science.abm9609
	7TYW	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Calcitonin-1	-	Gs/β1/γ2; RAMP1	3	2022-03-23	doi.org/10.1126/science.abm9609
	7TYW (No Gprot)	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Calcitonin-1	-		3	2022-03-23	doi.org/10.1126/science.abm9609
	7TYH	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Calcitonin	-	Gs/β1/γ2; RAMP2	3.3	2022-03-23	doi.org/10.1126/science.abm9609
	7TYH (No Gprot)	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Calcitonin	-		3.3	2022-03-23	doi.org/10.1126/science.abm9609
	7TYY	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Calcitonin-1	-	Gs/β1/γ2; RAMP2	3	2022-03-23	doi.org/10.1126/science.abm9609
	7TYY (No Gprot)	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Calcitonin-1	-		3	2022-03-23	doi.org/10.1126/science.abm9609
	7TZF	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Amylin	-	Gs/β1/γ2; RAMP3	2.4	2022-03-23	doi.org/10.1126/science.abm9609
	7TZF (No Gprot)	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Amylin	-		2.4	2022-03-23	doi.org/10.1126/science.abm9609
	7TYI	B1	Peptide	Calcitonin	CT	Homo sapiens	Amylin	-	Gs/β1/γ2	3.3	2022-03-30	doi.org/10.1126/science.abm9609
	7TYI (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	Amylin	-		3.3	2022-03-30	doi.org/10.1126/science.abm9609
	7TYN	B1	Peptide	Calcitonin	CT	Homo sapiens	Calcitonin-1	-	Gs/β1/γ2	2.6	2022-03-30	doi.org/10.1126/science.abm9609
	7TYN (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	Calcitonin-1	-		2.6	2022-03-30	doi.org/10.1126/science.abm9609
	7TYX	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Amylin	-	Gs/β1/γ2; RAMP2	2.55	2022-03-30	doi.org/10.1126/science.abm9609
	7TYX (No Gprot)	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Amylin	-		2.55	2022-03-30	doi.org/10.1126/science.abm9609
	7UM5	A	Amine	5-Hydroxytryptamine	5-HT_5A	Homo sapiens	5-CT	-	chim(NtGi1-Go)/β1/γ2	2.73	2022-07-20	doi.org/10.1038/s41594-022-00796-6
	7UM5 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_5A	Homo sapiens	5-CT	-		2.73	2022-07-20	doi.org/10.1038/s41594-022-00796-6
	7XTC	A	Amine	5-Hydroxytryptamine	5-HT₇	Homo sapiens	5-CT	-	Gs/β1/γ2	3.2	2022-07-27	doi.org/10.1016/j.molcel.2022.05.031
	7XTC (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT₇	Homo sapiens	5-CT	-		3.2	2022-07-27	doi.org/10.1016/j.molcel.2022.05.031
	7X5H	A	Amine	5-Hydroxytryptamine	5-HT_5A	Homo sapiens	5-CT	-	Gi1/β1/γ2	3.1	2022-09-14	doi.org/10.1038/s41421-022-00412-3
	7X5H (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_5A	Homo sapiens	5-CT	-		3.1	2022-09-14	doi.org/10.1038/s41421-022-00412-3
	8F0J	B1	Peptide	Calcitonin	CT	Homo sapiens	Pramlintide Analogue San45	-	Gs/β1/γ2	2	2023-08-02	doi.org/10.1038/s41589-023-01393-4
	8F0J (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	Pramlintide Analogue San45	-		2	2023-08-02	doi.org/10.1038/s41589-023-01393-4
	8F0K	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Pramlintide Analogue San385	-	Gs/β1/γ2; RAMP3	1.9	2023-08-02	doi.org/10.1038/s41589-023-01393-4
	8F0K (No Gprot)	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Pramlintide Analogue San385	-		1.9	2023-08-02	doi.org/10.1038/s41589-023-01393-4
	8F2A	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Pramlintide Analogue San385	-	Gs/β1/γ2; RAMP3	2.2	2023-08-02	doi.org/10.1038/s41589-023-01393-4
	8F2A (No Gprot)	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Pramlintide Analogue San385	-		2.2	2023-08-02	doi.org/10.1038/s41589-023-01393-4
	8F2B	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Pramlintide Analogue San45	-	Gs/β1/γ2; RAMP3	2	2023-08-02	doi.org/10.1038/s41589-023-01393-4
	8F2B (No Gprot)	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Pramlintide Analogue San45	-		2	2023-08-02	doi.org/10.1038/s41589-023-01393-4
	8ZQE	A	Orphan	Orphan	GPR15	Homo sapiens	GPR15L(CT)	-	Gi1/β1/γ1	2.9	2024-07-10	doi.org/10.1038/s41421-024-00698-5
	8ZQE (No Gprot)	A	Orphan	Orphan	GPR15	Homo sapiens	GPR15L(CT)	-		2.9	2024-07-10	doi.org/10.1038/s41421-024-00698-5
	9MNI	B1	Peptide	Calcitonin	CTLike	Homo sapiens	dC2_05	-	RAMP1	4.06	2025-10-22	doi.org/10.1101/2025.03.23.644666
	9AUC	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Calcitonin gene-related peptide-1	-	Gs/β1/γ2; RAMP1	2.4	2024-04-24	doi.org/10.1021/acs.biochem.4c00114
	9AUC (No Gprot)	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Calcitonin gene-related peptide-1	-		2.4	2024-04-24	doi.org/10.1021/acs.biochem.4c00114
	9BLB	B1	Peptide	Calcitonin	CT	Homo sapiens	Cagrilintide (non-acylated)	-	Gs/β1/γ2	3.2	2025-04-16	doi.org/10.1038/s41467-025-58680-y
	9BLB (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	Cagrilintide (non-acylated)	-		3.2	2025-04-16	doi.org/10.1038/s41467-025-58680-y
	9BLC	B1	Peptide	Calcitonin	CT	Homo sapiens	Cagrilintide (non-acylated)	-	Gs/β1/γ2	3.3	2025-04-16	doi.org/10.1038/s41467-025-58680-y
	9BLC (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	Cagrilintide (non-acylated)	-		3.3	2025-04-16	doi.org/10.1038/s41467-025-58680-y
	9BUE	B1	Peptide	Calcitonin	CT	Homo sapiens	Cagrilintide	-	Gs/β1/γ2	3.6	2025-04-16	doi.org/10.1038/s41467-025-58680-y
	9BUE (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	Cagrilintide	-		3.6	2025-04-16	doi.org/10.1038/s41467-025-58680-y
	9BLW	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Cagrilintide (non-acylated)	-	Gs/β1/γ2; RAMP1	3.2	2025-04-16	doi.org/10.1038/s41467-025-58680-y
	9BLW (No Gprot)	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Cagrilintide (non-acylated)	-		3.2	2025-04-16	doi.org/10.1038/s41467-025-58680-y
	9BTW	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Cagrilintide	-	Gs/β1/γ2; RAMP3	3	2025-04-16	To be published
	9BTW (No Gprot)	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Cagrilintide	-		3	2025-04-16	To be published
	9BUB	B1	Peptide	Calcitonin	CT	Homo sapiens	Cagrilintide	-	Gs/β1/γ2	2.3	2025-04-23	doi.org/10.1038/s41467-025-58680-y
	9BUB (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	Cagrilintide	-		2.3	2025-04-23	doi.org/10.1038/s41467-025-58680-y
	9BUC	B1	Peptide	Calcitonin	CT	Homo sapiens	Cagrilintide	-	Gs/β1/γ2	3.4	2025-04-23	doi.org/10.1038/s41467-025-58680-y
	9BUC (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	Cagrilintide	-		3.4	2025-04-23	doi.org/10.1038/s41467-025-58680-y
	9BUD	B1	Peptide	Calcitonin	CT	Homo sapiens	Cagrilintide	-	Gs/β1/γ2	2.5	2025-04-23	doi.org/10.1038/s41467-025-58680-y
	9BUD (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	Cagrilintide	-		2.5	2025-04-23	doi.org/10.1038/s41467-025-58680-y
	9BP3	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Cagrilintide	-	Gs/β1/γ2; RAMP1	2.2	2025-04-23	doi.org/10.1038/s41467-025-58680-y
	9BP3 (No Gprot)	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Cagrilintide	-		2.2	2025-04-23	doi.org/10.1038/s41467-025-58680-y
	9BQ3	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Cagrilintide	-	Gs/β1/γ2; RAMP2	2.8	2025-04-23	doi.org/10.1038/s41467-025-58680-y
	9BQ3 (No Gprot)	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Cagrilintide	-		2.8	2025-04-23	doi.org/10.1038/s41467-025-58680-y
	9UAP	A	Amine	Acetylcholine (muscarinic)	M₁	Homo sapiens	-	-	G11(CT)	3.62	2025-10-29	To be published
	9UCP	A	Amine	Acetylcholine (muscarinic)	M₁	Homo sapiens	Iperoxo	-	G11(CT)	2.88	2025-10-29	To be published
	9WXM	A	Orphan	Orphan	GPR15	Homo sapiens	GPR15L(CT)	-	Gi3/β1/γ2	3.3	2025-11-19	10.1016/j.isci.2025.113935
	9WXM (No Gprot)	A	Orphan	Orphan	GPR15	Homo sapiens	GPR15L(CT)	-		3.3	2025-11-19	10.1016/j.isci.2025.113935
	9W6W	A	Amine	5-Hydroxytryptamine	5-HT_5A	Homo sapiens	5-CT	-	Gi1/β1/γ2	3.13	2025-11-26	10.1186/s43556-025-00359-3
	9W6W (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_5A	Homo sapiens	5-CT	-		3.13	2025-11-26	10.1186/s43556-025-00359-3

2D representation of the interactions of this orthosteric/allosteric ligand.

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

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We apologize for the inconvenience.