psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:C1	L:L:C7	7.28	No	No	0	0	0
2	L:L:C1	R:R:L298	4.76	No	No	4	0	6
3	L:L:C1	R:R:H302	7.37	No	Yes	4	0	6
4	L:L:S2	R:R:Y299	7.63	No	No	0	0	7
5	L:L:N3	R:R:W361	12.43	No	No	0	0	4
6	L:L:L4	R:R:W361	4.56	No	No	0	0	4
7	L:L:S5	R:R:Y372	5.09	No	Yes	0	0	7
8	L:L:T6	R:R:H302	12.32	No	Yes	0	0	6
9	L:L:V8	R:R:H377	6.92	No	Yes	0	0	7
10	L:L:L9	R:R:I198	7.14	No	Yes	0	0	7
11	L:L:G10	R:R:V293	5.52	No	No	0	0	6
12	L:L:E15	L:L:K11	4.05	No	No	0	0	0
13	L:L:K11	R:R:R362	9.9	No	No	0	0	4
14	L:L:L12	R:R:L148	5.54	No	No	2	0	5
15	L:L:L12	R:R:H377	6.43	No	Yes	2	0	7
16	L:L:S13	R:R:H201	5.58	No	No	0	0	6
17	L:L:K18	L:L:Q14	6.78	No	No	0	0	0
18	L:L:Q14	R:R:V293	5.73	No	No	0	0	6
19	L:L:Q14	R:R:E294	8.92	No	No	0	0	3
20	L:L:E15	R:R:A145	4.53	No	No	0	0	4
21	L:L:L16	R:R:Y149	3.52	No	Yes	0	0	5
22	L:L:H17	R:R:L291	7.71	No	No	0	0	6
23	R:R:P139	R:R:T138	3.5	No	No	0	3	2
24	R:R:K141	R:R:T138	7.51	No	No	0	3	2
25	R:R:L142	R:R:Y146	4.69	No	No	0	2	2
26	R:R:K370	R:R:N144	4.2	No	No	2	4	4
27	R:R:N144	R:R:Y374	3.49	No	No	2	4	6
28	R:R:H377	R:R:L148	11.57	Yes	No	2	7	5
29	R:R:I153	R:R:Y149	7.25	No	Yes	0	7	5
30	R:R:L202	R:R:Y149	7.03	No	Yes	0	7	5
31	R:R:A152	R:R:H381	4.39	No	Yes	0	7	9
32	R:R:F382	R:R:G155	6.02	No	No	0	7	8
33	R:R:H156	R:R:S195	6.97	No	No	0	7	7
34	R:R:H156	R:R:I198	5.3	No	Yes	0	7	7
35	R:R:H156	R:R:H381	5.97	No	Yes	0	7	9
36	R:R:F382	R:R:L158	6.09	No	No	6	7	4
37	R:R:F385	R:R:L158	7.31	Yes	No	6	5	4
38	R:R:I160	R:R:I192	4.42	Yes	No	0	5	7
39	R:R:I160	R:R:S195	10.84	Yes	No	0	5	7
40	R:R:F385	R:R:T162	10.38	Yes	No	0	5	6
41	R:R:F188	R:R:L163	3.65	Yes	No	0	8	8
42	R:R:L163	R:R:Y191	7.03	No	Yes	0	8	8
43	R:R:F188	R:R:S166	7.93	Yes	No	0	8	9
44	R:R:F188	R:R:L167	8.53	Yes	No	0	8	6
45	R:R:F170	R:R:V181	9.18	Yes	No	0	8	9
46	R:R:F170	R:R:K185	4.96	Yes	No	0	8	6
47	R:R:F170	R:R:F188	6.43	Yes	Yes	0	8	8
48	R:R:C392	R:R:F170	4.19	No	Yes	0	9	8
49	R:R:R174	R:R:V171	5.23	No	No	0	7	4
50	R:R:F172	R:R:F173	9.65	No	Yes	0	2	7
51	R:R:F173	R:R:L176	3.65	Yes	No	7	7	9
52	R:R:F173	R:R:T401	3.89	Yes	No	7	7	7
53	R:R:F173	R:R:Q405	8.2	Yes	No	0	7	4
54	R:R:E397	R:R:L176	10.6	No	No	0	9	9
55	R:R:L176	R:R:T401	4.42	No	No	7	9	7
56	R:R:Q179	R:R:T182	4.25	Yes	No	0	7	5
57	R:R:Q179	R:R:Y243	5.64	Yes	Yes	0	7	8
58	R:R:K256	R:R:Q179	8.14	No	Yes	0	5	7
59	R:R:L259	R:R:Q179	7.99	No	Yes	0	5	7
60	R:R:R180	R:R:V181	3.92	No	No	0	9	9
61	R:R:H184	R:R:R180	4.51	No	No	0	9	9
62	R:R:E397	R:R:R180	3.49	No	No	0	9	9
63	R:R:L183	R:R:Y243	4.69	No	Yes	0	8	8
64	R:R:E240	R:R:H184	9.85	Yes	No	0	9	9
65	R:R:N186	R:R:W236	7.91	No	Yes	0	9	9
66	R:R:N186	R:R:Y263	11.63	No	No	0	9	5
67	R:R:M187	R:R:Y191	5.99	No	Yes	1	8	8
68	R:R:M187	R:R:W236	8.14	No	Yes	1	8	9
69	R:R:E240	R:R:M187	14.89	Yes	No	1	9	8
70	R:R:F188	R:R:V387	3.93	Yes	No	0	8	9
71	R:R:N233	R:R:T190	5.85	Yes	No	0	9	9
72	R:R:T190	R:R:W267	6.06	No	Yes	0	9	9
73	R:R:N233	R:R:Y191	9.3	Yes	Yes	1	9	8
74	R:R:M237	R:R:Y191	5.99	Yes	Yes	1	9	8
75	R:R:Q383	R:R:Y191	7.89	No	Yes	1	9	8
76	R:R:G384	R:R:Y191	4.35	No	Yes	0	9	8
77	R:R:V387	R:R:Y191	8.83	No	Yes	0	9	8
78	R:R:L193	R:R:M229	7.07	No	No	0	6	4
79	R:R:I198	R:R:N194	5.66	Yes	No	0	7	8
80	R:R:N194	R:R:N233	4.09	No	Yes	0	8	9
81	R:R:H226	R:R:I197	5.3	No	Yes	0	6	5
82	R:R:H226	R:R:I198	3.98	No	Yes	0	6	7
83	R:R:I200	R:R:L222	4.28	No	No	0	6	6
84	R:R:C219	R:R:E204	6.08	No	No	0	9	4
85	R:R:C219	R:R:C289	7.28	No	No	0	9	9
86	R:R:K220	R:R:W290	11.6	No	Yes	0	7	9
87	R:R:H223	R:R:Q227	12.36	No	Yes	0	5	7
88	R:R:H223	R:R:W290	12.7	No	Yes	0	5	9
89	R:R:F224	R:R:T274	7.78	No	No	0	5	6
90	R:R:H226	R:R:Q227	4.95	No	Yes	0	6	7
91	R:R:M230	R:R:Q227	4.08	No	Yes	0	6	7
92	R:R:I301	R:R:Q227	8.23	Yes	Yes	0	7	7
93	R:R:M229	R:R:Y228	4.79	No	Yes	0	4	8
94	R:R:W267	R:R:Y228	6.75	Yes	Yes	0	9	8
95	R:R:P270	R:R:Y228	5.56	Yes	Yes	0	9	8
96	R:R:L271	R:R:Y228	9.38	No	Yes	0	4	8
97	R:R:T274	R:R:Y228	4.99	No	Yes	0	6	8
98	R:R:M230	R:R:Y234	4.79	No	Yes	0	6	7
99	R:R:H302	R:R:M230	3.94	Yes	No	0	6	6
100	R:R:C232	R:R:W267	6.53	No	Yes	0	8	9
101	R:R:C232	R:R:P270	3.77	No	Yes	0	8	9
102	R:R:M237	R:R:N233	4.21	Yes	Yes	1	9	9
103	R:R:M237	R:R:Y234	4.79	Yes	Yes	0	9	7
104	R:R:V305	R:R:Y234	7.57	No	Yes	0	7	7
105	R:R:F356	R:R:Y234	10.32	Yes	Yes	0	7	7
106	R:R:F235	R:R:F269	8.57	No	No	0	5	3
107	R:R:F235	R:R:P270	8.67	No	Yes	0	5	9
108	R:R:E240	R:R:W236	6.54	Yes	Yes	1	9	9
109	R:R:G266	R:R:W236	4.22	No	Yes	0	9	9
110	R:R:W236	R:R:W267	9.37	Yes	Yes	0	9	9
111	R:R:M237	R:R:Q383	5.44	Yes	No	1	9	9
112	R:R:I242	R:R:L238	7.14	No	No	0	7	8
113	R:R:A308	R:R:L238	4.73	No	No	0	7	8
114	R:R:C239	R:R:L265	4.76	No	No	0	7	7
115	R:R:E240	R:R:L351	6.63	Yes	No	0	9	9
116	R:R:G241	R:R:N312	5.09	No	No	0	8	9
117	R:R:I242	R:R:Y262	6.04	No	No	0	7	7
118	R:R:F315	R:R:I242	3.77	No	No	0	8	7
119	R:R:L247	R:R:Y243	4.69	No	Yes	0	8	8
120	R:R:Y243	R:R:Y262	5.96	Yes	No	0	8	7
121	R:R:I319	R:R:L244	4.28	No	No	0	9	9
122	R:R:H245	R:R:V249	6.92	Yes	No	0	8	6
123	R:R:F315	R:R:H245	22.63	No	Yes	0	8	8
124	R:R:H245	R:R:N318	8.93	Yes	No	0	8	8
125	R:R:E255	R:R:T246	5.64	No	No	0	6	7
126	R:R:I248	R:R:I319	5.89	No	No	0	7	9
127	R:R:K256	R:R:T254	4.5	No	No	0	5	6
128	R:R:E255	R:R:R258	5.82	No	No	0	6	5
129	R:R:E255	R:R:Y262	7.86	No	No	0	6	7
130	R:R:R258	R:R:W261	5	No	No	0	5	2
131	R:R:L259	R:R:Y263	4.69	No	No	0	5	5
132	R:R:W267	R:R:Y263	3.86	Yes	No	0	9	5
133	R:R:F269	R:R:L265	3.65	No	No	0	3	7
134	R:R:P273	R:R:V272	5.3	No	No	0	6	4
135	R:R:H277	R:R:R281	12.41	Yes	No	0	7	7
136	R:R:H277	R:R:L298	7.71	Yes	No	0	7	6
137	R:R:H277	R:R:I300	5.3	Yes	No	0	7	8
138	R:R:H277	R:R:I301	7.95	Yes	Yes	0	7	7
139	R:R:D287	R:R:R281	11.91	Yes	No	0	3	7
140	R:R:R281	R:R:W290	16.99	No	Yes	0	7	9
141	R:R:L297	R:R:Y284	8.21	No	No	0	4	2
142	R:R:D287	R:R:F285	8.36	Yes	No	0	3	6
143	R:R:F285	R:R:T295	5.19	No	No	0	6	4
144	R:R:D287	R:R:N288	4.04	Yes	No	0	3	4
145	R:R:D287	R:R:S292	8.83	Yes	No	0	3	4
146	R:R:E294	R:R:S292	7.19	No	No	0	3	4
147	R:R:L297	R:R:T295	4.42	No	No	0	4	4
148	R:R:H296	R:R:Y299	15.24	No	No	0	2	7
149	R:R:H302	R:R:L298	3.86	Yes	No	4	6	6
150	R:R:H302	R:R:I301	3.98	Yes	Yes	0	6	7
151	R:R:G303	R:R:P304	4.06	No	No	0	4	9
152	R:R:F356	R:R:L309	4.87	Yes	No	0	7	7
153	R:R:L352	R:R:N312	8.24	Yes	No	0	9	9
154	R:R:F313	R:R:L317	6.09	No	No	0	6	5
155	R:R:F313	R:R:I354	6.28	No	Yes	0	6	6
156	R:R:F314	R:R:F315	6.43	No	No	0	5	8
157	R:R:F314	R:R:N318	9.67	No	No	0	5	8
158	R:R:L316	R:R:T345	4.42	Yes	No	0	9	9
159	R:R:L316	R:R:L348	5.54	Yes	No	3	9	9
160	R:R:L316	R:R:L352	4.15	Yes	Yes	3	9	9
161	R:R:I354	R:R:L316	4.28	Yes	Yes	3	6	9
162	R:R:M327	R:R:M337	4.33	No	No	0	7	7
163	R:R:K340	R:R:M327	10.08	No	No	0	8	7
164	R:R:M337	R:R:Y338	7.18	No	No	0	7	7
165	R:R:I347	R:R:I390	7.36	No	No	0	8	8
166	R:R:L348	R:R:L352	4.15	No	Yes	3	9	9
167	R:R:P350	R:R:V349	3.53	No	No	0	9	8
168	R:R:I354	R:R:V349	6.14	Yes	No	0	6	8
169	R:R:L351	R:R:Y391	19.93	No	No	0	9	8
170	R:R:I354	R:R:L352	5.71	Yes	Yes	3	6	9
171	R:R:G353	R:R:Q355	4.93	No	Yes	0	9	8
172	R:R:F356	R:R:Q355	14.05	Yes	Yes	0	7	8
173	R:R:Q355	R:R:Q383	11.52	Yes	No	0	8	9
174	R:R:F356	R:R:I380	7.54	Yes	No	0	7	6
175	R:R:F359	R:R:V358	5.24	Yes	No	0	6	5
176	R:R:F359	R:R:Y372	5.16	Yes	Yes	5	6	7
177	R:R:F359	R:R:M376	4.98	Yes	No	5	6	7
178	R:R:R362	R:R:Y372	4.12	No	Yes	0	4	7
179	R:R:L368	R:R:P363	6.57	No	No	0	3	7
180	R:R:P363	R:R:Y372	12.52	No	Yes	0	7	7
181	R:R:M367	R:R:N365	5.61	No	No	0	4	4
182	R:R:L368	R:R:N365	4.12	No	No	0	3	4
183	R:R:K370	R:R:Y374	13.14	No	No	2	4	6
184	R:R:M376	R:R:Y372	7.18	No	Yes	5	7	7
185	R:R:D373	R:R:H377	10.08	No	Yes	0	5	7
186	R:R:H377	R:R:H381	7.17	Yes	Yes	0	7	9
187	R:R:F382	R:R:F385	6.43	No	Yes	6	7	5
188	R:R:F385	R:R:F386	7.5	Yes	No	0	5	5
189	R:R:F393	R:R:T389	3.89	No	No	0	8	5
190	R:R:E397	R:R:N395	10.52	No	No	0	9	9
191	R:R:N395	R:R:V398	5.91	No	No	0	9	9
192	R:R:K403	R:R:Q399	4.07	No	No	0	6	7
193	R:R:Q405	R:R:Q408	7.68	No	No	0	4	7
194	R:R:K410	R:R:W406	4.64	No	No	0	4	6
195	R:R:Q408	R:R:Q412	3.84	No	No	0	7	4
196	R:R:I411	R:R:Q412	8.23	No	No	0	4	4
197	R:R:A388	R:R:S166	3.42	No	No	0	8	9
198	R:R:C178	R:R:V181	3.42	No	No	0	8	9
199	R:R:A231	R:R:I301	3.25	No	Yes	0	5	7
200	R:R:T345	R:R:V320	3.17	No	No	0	9	7
201	L:L:L16	R:R:A145	3.15	No	No	0	0	4
202	R:R:I199	R:R:S195	3.1	No	No	0	7	7
203	R:R:I248	R:R:V249	3.07	No	No	0	7	6
204	R:R:I354	R:R:V357	3.07	Yes	No	0	6	7
205	R:R:I279	R:R:T275	3.04	No	No	0	3	3
206	R:R:I300	R:R:T280	3.04	No	No	0	8	4
207	R:R:K326	R:R:V322	3.04	No	No	0	9	8
208	R:R:F409	R:R:W413	3.01	No	No	0	3	3
209	R:R:L163	R:R:S159	3	No	No	0	8	9
210	L:L:L4	L:L:T6	2.95	No	No	0	0	0
211	R:R:L271	R:R:T275	2.95	No	No	0	4	3
212	R:R:I276	R:R:I300	2.94	No	No	0	5	8
213	R:R:I347	R:R:K343	2.91	No	No	0	8	8
214	R:R:F235	R:R:P304	2.89	No	No	0	5	9
215	R:R:F386	R:R:P350	2.89	No	No	0	5	9
216	R:R:Q355	R:R:V349	2.87	Yes	No	0	8	8
217	R:R:I198	R:R:L202	2.85	Yes	No	0	7	7
218	R:R:L323	R:R:M327	2.83	No	No	0	9	7
219	R:R:C392	R:R:F393	2.79	No	No	0	9	8
220	L:L:L19	R:R:L142	2.77	No	No	0	0	2
221	R:R:H201	R:R:V205	2.77	No	No	0	6	7
222	R:R:A278	R:R:F224	2.77	No	No	0	6	5
223	R:R:H245	R:R:V250	2.77	Yes	No	0	8	5
224	R:R:L148	R:R:N144	2.75	No	No	2	5	4
225	R:R:L379	R:R:Q355	2.66	No	Yes	0	5	8
226	R:R:F269	R:R:V272	2.62	No	No	0	3	4
227	R:R:A282	R:R:W290	2.59	No	Yes	0	3	9
228	R:R:H381	R:R:L151	2.57	Yes	No	0	9	5
229	R:R:H201	R:R:L291	2.57	No	No	0	6	6
230	R:R:F161	R:R:I160	2.51	No	Yes	0	4	5
231	R:R:F173	R:R:I169	2.51	Yes	No	0	7	8
232	R:R:F225	R:R:I221	2.51	No	No	0	5	4
233	R:R:M337	R:R:R328	2.48	No	No	0	7	6
234	R:R:I390	R:R:Y391	2.42	No	No	0	8	8
235	L:L:L16	R:R:Y146	2.34	No	No	0	0	2
236	R:R:L189	R:R:W267	2.28	No	Yes	0	3	9
237	R:R:G268	R:R:P270	2.03	No	Yes	0	6	9
238	R:R:G369	R:R:P363	2.03	No	No	0	4	7
239	R:R:F409	R:R:W406	2	No	No	0	3	6
240	R:R:G155	R:R:V154	1.84	No	No	0	8	6
241	R:R:G168	R:R:V171	1.84	No	No	0	1	4
242	R:R:A341	R:R:V324	1.7	No	No	0	9	5
243	R:R:C394	R:R:T389	1.69	No	No	0	5	5
244	R:R:A251	R:R:T246	1.68	No	No	0	6	7
245	R:R:V249	R:R:V322	1.6	No	No	0	6	8
246	R:R:V398	R:R:V402	1.6	No	No	0	9	5
247	R:R:C289	R:R:L291	1.59	No	No	0	9	6
248	R:R:A344	R:R:L323	1.58	No	No	0	9	9
249	R:R:T400	R:R:T401	1.57	No	No	0	4	7
250	R:R:I199	R:R:S157	1.55	No	No	0	7	7
251	R:R:I165	R:R:V164	1.54	No	No	0	5	4
252	R:R:I192	R:R:V164	1.54	No	No	0	7	4
253	R:R:I200	R:R:V203	1.54	No	No	0	6	3
254	R:R:I221	R:R:V217	1.54	No	No	0	4	3
255	R:R:I371	R:R:V375	1.54	No	No	0	5	4
256	R:R:K143	R:R:V147	1.52	No	No	0	1	4
257	L:L:L4	L:L:S2	1.5	No	No	0	0	0
258	L:L:S13	R:R:L202	1.5	No	No	0	0	7
259	R:R:K326	R:R:T325	1.5	No	No	0	9	7
260	R:R:L238	R:R:V311	1.49	No	No	0	8	6
261	R:R:I197	R:R:I200	1.47	Yes	No	0	5	6
262	R:R:I160	R:R:M196	1.46	Yes	No	0	5	4
263	R:R:I197	R:R:M196	1.46	Yes	No	0	5	4
264	R:R:I347	R:R:M346	1.46	No	No	0	8	8
265	R:R:N396	R:R:T400	1.46	No	No	0	6	4
266	R:R:F359	R:R:P360	1.44	Yes	No	0	6	5
267	R:R:I371	R:R:L368	1.43	No	No	0	5	3
268	L:L:L19	R:R:K141	1.41	No	No	0	0	3
269	R:R:K220	R:R:N286	1.4	No	No	0	7	7
270	R:R:K256	R:R:Q257	1.36	No	No	0	5	5
271	R:R:E140	R:R:K143	1.35	No	No	0	2	1
272	R:R:R328	R:R:V324	1.31	No	No	0	6	5
273	R:R:F225	R:R:I197	1.26	No	Yes	0	5	5
274	R:R:N318	R:R:R321	1.21	No	No	0	8	8
275	R:R:Y149	R:R:Y150	0.99	Yes	No	0	5	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Y149	4.6975	4	0	5
2	R:R:I160	4.8075	4	0	5
3	R:R:F170	6.19	4	0	8
4	R:R:F173	5.58	5	7	7
5	R:R:Q179	6.505	4	0	7
6	R:R:F188	6.094	5	0	8
7	R:R:Y191	7.05429	7	1	8
8	R:R:I197	2.3725	4	0	5
9	R:R:I198	4.986	5	0	7
10	R:R:Q227	7.405	4	0	7
11	R:R:Y228	6.294	5	0	8
12	R:R:N233	5.8625	4	1	9
13	R:R:Y234	6.8675	4	0	7
14	R:R:W236	7.236	5	1	9
15	R:R:M237	5.1075	4	1	9
16	R:R:E240	9.4775	4	1	9
17	R:R:Y243	5.245	4	0	8
18	R:R:H245	10.3125	4	0	8
19	R:R:W267	5.80833	6	0	9
20	R:R:P270	5.0075	4	0	9
21	R:R:H277	8.3425	4	0	7
22	R:R:D287	8.285	4	0	3
23	R:R:W290	10.97	4	0	9
24	R:R:I301	5.8525	4	0	7
25	R:R:H302	6.294	5	4	6
26	R:R:L316	4.5975	4	3	9
27	R:R:L352	5.5625	4	3	9
28	R:R:I354	5.096	5	3	6
29	R:R:Q355	7.206	5	0	8
30	R:R:F356	9.195	4	0	7
31	R:R:F359	4.205	4	5	6
32	R:R:Y372	6.814	5	5	7
33	R:R:H377	8.434	5	2	7
34	R:R:H381	5.025	4	0	9
35	R:R:F385	7.905	4	6	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:T6	R:R:H302	13.1763	12.32	No	Yes	0	0	6
2	L:L:L4	L:L:T6	11.3251	2.95	No	No	0	0	0
3	R:R:H302	R:R:M230	43.6134	3.94	Yes	No	0	6	6
4	R:R:M230	R:R:Q227	40.0223	4.08	No	Yes	0	6	7
5	R:R:H226	R:R:Q227	39.8578	4.95	No	Yes	0	6	7
6	R:R:H226	R:R:I198	41.7409	3.98	No	Yes	0	6	7
7	R:R:I198	R:R:L202	54.3232	2.85	Yes	No	0	7	7
8	R:R:L202	R:R:Y149	42.0062	7.03	No	Yes	0	7	5
9	L:L:L16	R:R:Y149	37.7095	3.52	No	Yes	0	0	5
10	L:L:L16	R:R:A145	27.3128	3.15	No	No	0	0	4
11	L:L:E15	R:R:A145	25.7851	4.53	No	No	0	0	4
12	L:L:E15	L:L:K11	24.2468	4.05	No	No	0	0	0
13	L:L:K11	R:R:R362	22.6979	9.9	No	No	0	0	4
14	R:R:R362	R:R:Y372	21.2338	4.12	No	Yes	0	4	7
15	R:R:H302	R:R:I301	21.1755	3.98	Yes	Yes	0	6	7
16	R:R:I301	R:R:Q227	34.4101	8.23	Yes	Yes	0	7	7
17	R:R:H156	R:R:I198	29.4929	5.3	No	Yes	0	7	7
18	R:R:H156	R:R:H381	17.9875	5.97	No	Yes	0	7	9
19	R:R:H377	R:R:H381	13.1816	7.17	Yes	Yes	0	7	9
20	R:R:H277	R:R:L298	15.8551	7.71	Yes	No	0	7	6
21	R:R:H277	R:R:R281	44.478	12.41	Yes	No	0	7	7
22	R:R:D287	R:R:R281	59.7655	11.91	Yes	No	0	3	7
23	R:R:D287	R:R:S292	30.0711	8.83	Yes	No	0	3	4
24	R:R:E294	R:R:S292	25.0849	7.19	No	No	0	3	4
25	L:L:Q14	R:R:E294	20.0881	8.92	No	No	0	0	3
26	L:L:Q14	R:R:V293	10.0626	5.73	No	No	0	0	6
27	L:L:S13	R:R:L202	13.2771	1.5	No	No	0	0	7
28	L:L:S13	R:R:H201	11.6539	5.58	No	No	0	0	6
29	L:L:L16	R:R:Y146	10.0202	2.34	No	No	0	0	2
30	R:R:M230	R:R:Y234	75.1857	4.79	No	Yes	0	6	7
31	R:R:F356	R:R:Y234	18.2156	10.32	Yes	Yes	0	7	7
32	R:R:F356	R:R:Q355	14.2637	14.05	Yes	Yes	0	7	8
33	R:R:Q355	R:R:V349	58.2219	2.87	Yes	No	0	8	8
34	R:R:P350	R:R:V349	22.8252	3.53	No	No	0	9	8
35	R:R:F386	R:R:P350	20.0085	2.89	No	No	0	5	9
36	R:R:F385	R:R:F386	17.1812	7.5	Yes	No	0	5	5
37	R:R:H156	R:R:S195	11.0651	6.97	No	No	0	7	7
38	R:R:H226	R:R:I197	14.1683	5.3	No	Yes	0	6	5
39	R:R:M237	R:R:Y234	63.1869	4.79	Yes	Yes	0	9	7
40	R:R:M237	R:R:Y191	27.7477	5.99	Yes	Yes	1	9	8
41	R:R:L163	R:R:Y191	25.4403	7.03	No	Yes	0	8	8
42	R:R:F188	R:R:L163	21.7802	3.65	Yes	No	0	8	8
43	R:R:V387	R:R:Y191	23.4617	8.83	No	Yes	0	9	8
44	R:R:F188	R:R:V387	21.6317	3.93	Yes	No	0	8	9
45	R:R:F170	R:R:F188	28.0766	6.43	Yes	Yes	0	8	8
46	R:R:C392	R:R:F170	18.4543	4.19	No	Yes	0	9	8
47	R:R:M187	R:R:Y191	56.1744	5.99	No	Yes	1	8	8
48	R:R:E240	R:R:M187	24.809	14.89	Yes	No	1	9	8
49	R:R:E240	R:R:H184	32.177	9.85	Yes	No	0	9	9
50	R:R:H184	R:R:R180	30.6917	4.51	No	No	0	9	9
51	R:R:E397	R:R:R180	25.5039	3.49	No	No	0	9	9
52	R:R:E397	R:R:L176	18.9794	10.6	No	No	0	9	9
53	R:R:F173	R:R:L176	12.0995	3.65	Yes	No	7	7	9
54	R:R:M237	R:R:N233	52.3711	4.21	Yes	Yes	1	9	9
55	R:R:N233	R:R:T190	100	5.85	Yes	No	0	9	9
56	R:R:T190	R:R:W267	99.0399	6.06	No	Yes	0	9	9
57	R:R:W267	R:R:Y263	72.9684	3.86	Yes	No	0	9	5
58	R:R:L259	R:R:Y263	86.0015	4.69	No	No	0	5	5
59	R:R:L259	R:R:Q179	83.6251	7.99	No	Yes	0	5	7
60	R:R:Q179	R:R:Y243	71.7271	5.64	Yes	Yes	0	7	8
61	R:R:M187	R:R:W236	30.9198	8.14	No	Yes	1	8	9
62	R:R:N186	R:R:W236	17.5896	7.91	No	Yes	0	9	9
63	R:R:M237	R:R:Q383	17.5949	5.44	Yes	No	1	9	9
64	R:R:W267	R:R:Y228	40.1178	6.75	Yes	Yes	0	9	8
65	R:R:I198	R:R:N194	77.8379	5.66	Yes	No	0	7	8
66	R:R:N194	R:R:N233	78.2039	4.09	No	Yes	0	8	9
67	R:R:R281	R:R:W290	21.3081	16.99	No	Yes	0	7	9
68	R:R:H223	R:R:Q227	28.7927	12.36	No	Yes	0	5	7
69	R:R:P270	R:R:Y228	21.5468	5.56	Yes	Yes	0	9	8
70	R:R:C232	R:R:W267	23.1912	6.53	No	Yes	0	8	9
71	R:R:C232	R:R:P270	21.1277	3.77	No	Yes	0	8	9
72	R:R:F235	R:R:P270	34.0972	8.67	No	Yes	0	5	9
73	R:R:F235	R:R:F269	21.5574	8.57	No	No	0	5	3
74	R:R:Y243	R:R:Y262	64.4812	5.96	Yes	No	0	8	7
75	R:R:I242	R:R:Y262	49.5597	6.04	No	No	0	7	7
76	R:R:E240	R:R:L351	10.5718	6.63	Yes	No	0	9	9
77	R:R:I354	R:R:V349	33.7312	6.14	Yes	No	0	6	8
78	R:R:I354	R:R:L352	11.4099	5.71	Yes	Yes	3	6	9
79	R:R:F315	R:R:I242	39.407	3.77	No	No	0	8	7
80	R:R:F315	R:R:H245	28.9465	22.63	No	Yes	0	8	8
81	R:R:H245	R:R:V249	18.5232	6.92	Yes	No	0	8	6
82	R:R:E255	R:R:Y262	13.4575	7.86	No	No	0	6	7
83	R:R:H277	R:R:I300	10.3862	5.3	Yes	No	0	7	8
84	R:R:D287	R:R:F285	20.0881	8.36	Yes	No	0	3	6
85	R:R:F285	R:R:T295	15.0806	5.19	No	No	0	6	4
86	R:R:L297	R:R:T295	10.0626	4.42	No	No	0	4	4
87	R:R:I354	R:R:L316	11.15	4.28	Yes	Yes	3	6	9
88	R:R:P363	R:R:Y372	11.6539	12.52	No	Yes	0	7	7
89	R:R:C392	R:R:F393	13.8553	2.79	No	No	0	9	8
90	R:R:H302	R:R:L298	16.7728	3.86	Yes	No	4	6	6
91	R:R:H277	R:R:I301	42.4517	7.95	Yes	Yes	0	7	7
92	R:R:H223	R:R:W290	27.1854	12.7	No	Yes	0	5	9
93	R:R:N233	R:R:Y191	46.7802	9.3	Yes	Yes	1	9	8
94	R:R:Q383	R:R:Y191	38.8447	7.89	No	Yes	1	9	8
95	R:R:Q355	R:R:Q383	53.7715	11.52	Yes	No	0	8	9
96	R:R:W236	R:R:W267	31.4715	9.37	Yes	Yes	0	9	9
97	R:R:N186	R:R:Y263	16.4333	11.63	No	No	0	9	5
98	R:R:E240	R:R:W236	17.8443	6.54	Yes	Yes	1	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:C1	R:R:L298	4.76	4	No	No	0	6	0	1
L:L:C1	R:R:H302	7.37	4	No	Yes	0	6	0	1
L:L:S2	R:R:Y299	7.63	0	No	No	0	7	0	1
L:L:N3	R:R:W361	12.43	0	No	No	0	4	0	1
L:L:L4	R:R:W361	4.56	0	No	No	0	4	0	1
L:L:S5	R:R:Y372	5.09	0	No	Yes	0	7	0	1
L:L:T6	R:R:H302	12.32	0	No	Yes	0	6	0	1
L:L:V8	R:R:H377	6.92	0	No	Yes	0	7	0	1
L:L:L9	R:R:I198	7.14	0	No	Yes	0	7	0	1
L:L:G10	R:R:V293	5.52	0	No	No	0	6	0	1
L:L:K11	R:R:R362	9.9	0	No	No	0	4	0	1
L:L:L12	R:R:L148	5.54	2	No	No	0	5	0	1
L:L:L12	R:R:H377	6.43	2	No	Yes	0	7	0	1
L:L:S13	R:R:H201	5.58	0	No	No	0	6	0	1
L:L:Q14	R:R:V293	5.73	0	No	No	0	6	0	1
L:L:Q14	R:R:E294	8.92	0	No	No	0	3	0	1
L:L:E15	R:R:A145	4.53	0	No	No	0	4	0	1
L:L:L16	R:R:Y149	3.52	0	No	Yes	0	5	0	1
L:L:H17	R:R:L291	7.71	0	No	No	0	6	0	1
R:R:K141	R:R:T138	7.51	0	No	No	3	2	1	2
R:R:L142	R:R:Y146	4.69	0	No	No	2	2	1	1
R:R:H377	R:R:L148	11.57	2	Yes	No	7	5	1	1
R:R:I153	R:R:Y149	7.25	0	No	Yes	7	5	2	1
R:R:L202	R:R:Y149	7.03	0	No	Yes	7	5	1	1
R:R:H156	R:R:I198	5.3	0	No	Yes	7	7	2	1
R:R:H156	R:R:H381	5.97	0	No	Yes	7	9	2	2
R:R:I198	R:R:N194	5.66	0	Yes	No	7	8	1	2
R:R:H226	R:R:I198	3.98	0	No	Yes	6	7	2	1
R:R:H302	R:R:M230	3.94	4	Yes	No	6	6	1	2
R:R:H277	R:R:L298	7.71	0	Yes	No	7	6	2	1
R:R:H277	R:R:I301	7.95	0	Yes	Yes	7	7	2	2
R:R:E294	R:R:S292	7.19	0	No	No	3	4	1	2
R:R:H296	R:R:Y299	15.24	0	No	No	2	7	2	1
R:R:H302	R:R:L298	3.86	4	Yes	No	6	6	1	1
R:R:H302	R:R:I301	3.98	4	Yes	Yes	6	7	1	2
R:R:F359	R:R:Y372	5.16	5	Yes	Yes	6	7	2	1
R:R:F359	R:R:M376	4.98	5	Yes	No	6	7	2	2
R:R:R362	R:R:Y372	4.12	0	No	Yes	4	7	1	1
R:R:P363	R:R:Y372	12.52	0	No	Yes	7	7	2	1
R:R:M376	R:R:Y372	7.18	5	No	Yes	7	7	2	1
R:R:D373	R:R:H377	10.08	0	No	Yes	5	7	2	1
R:R:H377	R:R:H381	7.17	2	Yes	Yes	7	9	1	2
L:L:L16	R:R:A145	3.15	0	No	No	0	4	0	1
R:R:I198	R:R:L202	2.85	0	Yes	No	7	7	1	1
L:L:L19	R:R:L142	2.77	0	No	No	0	2	0	1
R:R:H201	R:R:V205	2.77	0	No	No	6	7	1	2
R:R:L148	R:R:N144	2.75	2	No	No	5	4	1	2
R:R:H201	R:R:L291	2.57	0	No	No	6	6	1	1
L:L:L16	R:R:Y146	2.34	0	No	No	0	2	0	1
R:R:C289	R:R:L291	1.59	0	No	No	9	6	2	1
L:L:S13	R:R:L202	1.5	0	No	No	0	7	0	1
L:L:L19	R:R:K141	1.41	0	No	No	0	3	0	1
R:R:Y149	R:R:Y150	0.99	0	Yes	No	5	4	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	6NIY_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.49
Number of Linked Nodes	258
Number of Links	275
Number of Hubs	35
Number of Links mediated by Hubs	135
Number of Communities	7
Number of Nodes involved in Communities	29
Number of Links involved in Communities	33

Path Summary
Number Of Nodes in MetaPath	99
Number Of Links MetaPath	98
Number of Shortest Paths	56065
Length Of Smallest Path	3
Average Path Length	13.5665
Length of Longest Path	29
Minimum Path Strength	1.36
Average Path Strength	6.33777
Maximum Path Strength	15.78
Minimum Path Correlation	0.7
Average Path Correlation	0.939564
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	4.34783
Average % Of Corr. Nodes	54.8332
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	43.0465
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • molecular function activator activity • phosphorus-oxygen lyase activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • adenylate cyclase activator activity • adenylate cyclase activity • cation binding • metal ion binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • biological regulation • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of biological process • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • protein localization • regulation of localization • establishment of protein localization • nitrogen compound transport • localization • cellular macromolecule localization • regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • protein transport • regulation of cellular localization • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • amide binding • amyloid-beta binding • binding • peptide binding • calcitonin family receptor activity • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • calcitonin receptor activity • amylin receptor activity • calcitonin gene-related peptide receptor activity • calcitonin binding • calcitonin family binding • peptide hormone binding • hormone binding • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • cellular response to stimulus • positive regulation of cell communication • regulation of cellular process • positive regulation of signal transduction • response to stimulus • signaling • positive regulation of biological process • regulation of signal transduction • intracellular signal transduction • cell communication • positive regulation of response to stimulus • regulation of intracellular signal transduction • intracellular signaling cassette • regulation of calcium-mediated signaling • positive regulation of calcium-mediated signaling • signal transduction • positive regulation of cellular process • regulation of biological process • regulation of signaling • positive regulation of intracellular signal transduction • regulation of response to stimulus • calcium-mediated signaling • regulation of cell communication • cellular process • positive regulation of signaling • catabolic process • negative regulation of biological process • RNA metabolic process • macromolecule catabolic process • regulation of primary metabolic process • nucleobase-containing compound metabolic process • post-transcriptional regulation of gene expression • regulation of RNA metabolic process • regulation of mRNA catabolic process • negative regulation of cellular process • regulation of nucleobase-containing compound metabolic process • RNA catabolic process • negative regulation of macromolecule metabolic process • regulation of biosynthetic process • mRNA catabolic process • negative regulation of metabolic process • primary metabolic process • regulation of macromolecule metabolic process • regulation of catabolic process • gene expression • mRNA metabolic process • macromolecule biosynthetic process • nucleic acid metabolic process • nucleobase-containing compound catabolic process • regulation of mRNA stability • regulation of gene expression • negative regulation of gene expression • biosynthetic process • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • regulation of RNA stability • nucleic acid catabolic process • metabolic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • regulation of mRNA metabolic process • regulation of metabolic process • positive regulation of ERK1 and ERK2 cascade • positive regulation of MAPK cascade • regulation of MAPK cascade • MAPK cascade • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of macromolecule biosynthetic process • positive regulation of metabolic process • positive regulation of gene expression • positive regulation of biosynthetic process • positive regulation of macromolecule metabolic process • amylin receptor 1 signaling pathway • amylin receptor signaling pathway • calcitonin family receptor signaling pathway • G protein-coupled receptor signaling pathway • regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • phosphatidylinositol 3-kinase/protein kinase B signal transduction • response to corticosteroid • response to lipid • response to hormone • response to steroid hormone • response to chemical • response to endogenous stimulus • response to glucocorticoid • adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • response to amyloid-beta • cell surface receptor signaling pathway • calcitonin gene-related peptide receptor signaling pathway • multicellular organismal process • ossification • amylin receptor 2 signaling pathway • developmental process • myeloid leukocyte differentiation • cellular developmental process • hemopoiesis • cell development • myeloid cell differentiation • cell differentiation • osteoclast differentiation • anatomical structure development • leukocyte differentiation • positive regulation of cAMP/PKA signal transduction • cAMP/PKA signal transduction • regulation of cAMP/PKA signal transduction • regulation of multicellular organismal process • negative regulation of multicellular organismal process • regulation of ossification • negative regulation of ossification • amylin receptor 3 signaling pathway • cell projection • cilium • plasma membrane bounded cell projection • amylin receptor complex • amylin receptor complex 3 • receptor complex • plasma membrane signaling receptor complex • G protein-coupled receptor complex • calcitonin family receptor complex • amylin receptor complex 2 • amylin receptor complex 1 • axon • neuron projection • acrosomal vesicle • intracellular vesicle • cytoplasmic vesicle • secretory granule • secretory vesicle • protein binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • sensory system development • system development • cell population proliferation • response to ketone • response to prostaglandin • response to alcohol • cellular response to prostaglandin stimulus • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • calcitonin receptor binding • signaling receptor binding • G protein-coupled receptor binding • molecular function activator activity • signaling receptor activator activity • hormone activity • molecular function regulator activity • signaling receptor regulator activity • receptor ligand activity
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P30988
Sequence	>6NIY_nogp_Chain_R T P E K L K N A Y V L Y Y L A I V G H S L S I F T L V I S L G I F V F F R S L G C Q R V T L H K N M F L T Y I L N S M I I I I H L V E V V S C K I L H F F H Q Y M M A C N Y F W M L C E G I Y L H T L I V V A V F T E K Q R L R W Y Y L L G W G F P L V P T T I H A I T R A V Y F N D N C W L S V E T H L L Y I I H G P V M A A L V V N F F F L L N I V R V L V T K M R E T H M Y L K A V K A T M I L V P L L G I Q F V V F P W R P S N K M L G K I Y D Y V M H S L I H F Q G F F V A T I Y C F C N N E V Q T T V K R Q W A Q F K I Q W N Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9AUC	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Calcitonin gene-related peptide-1	-	Gs/β1/γ2; RAMP1	2.4	2024-04-24	10.1021/acs.biochem.4c00114
	9AUC (No Gprot)	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Calcitonin gene-related peptide-1	-		2.4	2024-04-24	10.1021/acs.biochem.4c00114
	8F0J	B1	Peptide	Calcitonin	CT	Homo sapiens	Pramlintide Analogue San45	-	Gs/β1/γ2	2	2023-08-02	10.1038/s41589-023-01393-4
	8F0J (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	Pramlintide Analogue San45	-		2	2023-08-02	10.1038/s41589-023-01393-4
	8F2B	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Pramlintide Analogue San45	-	Gs/β1/γ2; RAMP3	2	2023-08-02	10.1038/s41589-023-01393-4
	8F2B (No Gprot)	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Pramlintide Analogue San45	-		2	2023-08-02	10.1038/s41589-023-01393-4
	8F2A	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Pramlintide Analogue San385	-	Gs/β1/γ2; RAMP3	2.2	2023-08-02	10.1038/s41589-023-01393-4
	8F2A (No Gprot)	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Pramlintide Analogue San385	-		2.2	2023-08-02	10.1038/s41589-023-01393-4
	8F0K	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Pramlintide Analogue San385	-	Gs/β1/γ2; RAMP3	1.9	2023-08-02	10.1038/s41589-023-01393-4
	8F0K (No Gprot)	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Pramlintide Analogue San385	-		1.9	2023-08-02	10.1038/s41589-023-01393-4
	7X5H	A	Amine	5-Hydroxytryptamine	5-HT_5A	Homo sapiens	5-CT	-	Gi1/β1/γ2	3.1	2022-09-14	10.1038/s41421-022-00412-3
	7X5H (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_5A	Homo sapiens	5-CT	-		3.1	2022-09-14	10.1038/s41421-022-00412-3
	7XTC	A	Amine	5-Hydroxytryptamine	5-HT₇	Homo sapiens	5-CT	-	Gs/β1/γ2	3.2	2022-07-27	10.1016/j.molcel.2022.05.031
	7XTC (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT₇	Homo sapiens	5-CT	-		3.2	2022-07-27	10.1016/j.molcel.2022.05.031
	7UM5	A	Amine	5-Hydroxytryptamine	5-HT_5A	Homo sapiens	5-CT	-	chim(NtGi1-Go)/β1/γ2	2.73	2022-07-20	10.1038/s41594-022-00796-6
	7UM5 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_5A	Homo sapiens	5-CT	-		2.73	2022-07-20	10.1038/s41594-022-00796-6
	7TYN	B1	Peptide	Calcitonin	CT	Homo sapiens	Calcitonin-1	-	Gs/β1/γ2	2.6	2022-03-30	10.1126/science.abm9609
	7TYN (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	Calcitonin-1	-		2.6	2022-03-30	10.1126/science.abm9609
	7TYI	B1	Peptide	Calcitonin	CT	Homo sapiens	Amylin	-	Gs/β1/γ2	3.3	2022-03-30	10.1126/science.abm9609
	7TYI (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	Amylin	-		3.3	2022-03-30	10.1126/science.abm9609
	7TYX	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Amylin	-	Gs/β1/γ2; RAMP2	2.55	2022-03-30	10.1126/science.abm9609
	7TYX (No Gprot)	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Amylin	-		2.55	2022-03-30	10.1126/science.abm9609
	7TYO	B1	Peptide	Calcitonin	CT	Homo sapiens	Calcitonin	-	Gs/β1/γ2	2.7	2022-03-23	10.1126/science.abm9609
	7TYO (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	Calcitonin	-		2.7	2022-03-23	10.1126/science.abm9609
	7TYL	B1	Peptide	Calcitonin	CT	Homo sapiens	Amylin	-	Gs/β1/γ2	3.3	2022-03-23	10.1126/science.abm9609
	7TYL (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	Amylin	-		3.3	2022-03-23	10.1126/science.abm9609
	7TYW	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Calcitonin-1	-	Gs/β1/γ2; RAMP1	3	2022-03-23	10.1126/science.abm9609
	7TYW (No Gprot)	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Calcitonin-1	-		3	2022-03-23	10.1126/science.abm9609
	7TYF	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Amylin	-	Gs/β1/γ2; RAMP1	2.2	2022-03-23	10.1126/science.abm9609
	7TYF (No Gprot)	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Amylin	-		2.2	2022-03-23	10.1126/science.abm9609
	7TYY	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Calcitonin-1	-	Gs/β1/γ2; RAMP2	3	2022-03-23	10.1126/science.abm9609
	7TYY (No Gprot)	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Calcitonin-1	-		3	2022-03-23	10.1126/science.abm9609
	7TYH	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Calcitonin-1	-	Gs/β1/γ2; RAMP2	3.3	2022-03-23	10.1126/science.abm9609
	7TYH (No Gprot)	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Calcitonin-1	-		3.3	2022-03-23	10.1126/science.abm9609
	7TZF	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Amylin	-	Gs/β1/γ2; RAMP3	2.4	2022-03-23	10.1126/science.abm9609
	7TZF (No Gprot)	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Amylin	-		2.4	2022-03-23	10.1126/science.abm9609
	7KNU	B1	Peptide	Calcitonin	CT Like	Homo sapiens	Calcitonin gene-related peptide-1	-	RAMP1	3.49	2021-02-24	10.1126/science.abf7258
	7KNT	B1	Peptide	Calcitonin	CT Like	Homo sapiens	-	-	RAMP1	3.15	2021-02-24	10.1126/science.abf7258
	6PH7	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	Nerol	Gt(CT)	2.9	2020-07-01	To be published
	6PGS	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	Geraniol	Gt(CT)	2.9	2020-07-01	To be published
	6PEL	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	Citronellol	Gt(CT)	3.19	2020-06-24	To be published
	6UVA	B1	Peptide	Calcitonin	CT Like (AM2)	Homo sapiens	Adrenomedullin-2	-	Gs/β1/γ2; RAMP3	2.3	2020-04-01	10.1021/acsptsci.9b00080
	6UVA (No Gprot)	B1	Peptide	Calcitonin	CT Like (AM2)	Homo sapiens	Adrenomedullin-2	-		2.3	2020-04-01	10.1021/acsptsci.9b00080
	6UUS	B1	Peptide	Calcitonin	CT Like (AM2)	Homo sapiens	Adrenomedullin	-	Gs/β1/γ2; RAMP3	2.4	2020-04-01	10.1021/acsptsci.9b00080
	6UUS (No Gprot)	B1	Peptide	Calcitonin	CT Like (AM2)	Homo sapiens	Adrenomedullin	-		2.4	2020-04-01	10.1021/acsptsci.9b00080
	6UUN	B1	Peptide	Calcitonin	CT Like (AM1)	Homo sapiens	Adrenomedullin	-	Gs/β1/γ2; RAMP2	3	2020-03-25	10.1021/acsptsci.9b00080
	6UUN (No Gprot)	B1	Peptide	Calcitonin	CT Like (AM1)	Homo sapiens	Adrenomedullin	-		3	2020-03-25	10.1021/acsptsci.9b00080
	6NWE	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl-β-D-Glucopyranoside	-	Gt(CT)	2.71	2020-02-12	To be published
	6TP4	A	Peptide	Orexin	OX₁	Homo sapiens	ACT-462206	-	-	3.01	2020-01-01	10.1021/acs.jmedchem.9b01787
	6NIY	B1	Peptide	Calcitonin	CT	Homo sapiens	Adrenomedullin	-	Gs/β1/γ2	3.34	2019-01-23	10.1021/acsptsci.8b00056
	6NIY (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	Adrenomedullin	-		3.34	2019-01-23	10.1021/acsptsci.8b00056
	6E3Y	B1	Peptide	Calcitonin	CT Like	Homo sapiens	Calcitonin gene-related peptide-1	-	Gs/β1/γ2; RAMP1	3.3	2018-09-19	10.1038/s41586-018-0535-y
	6E3Y (No Gprot)	B1	Peptide	Calcitonin	CT Like	Homo sapiens	Calcitonin gene-related peptide-1	-		3.3	2018-09-19	10.1038/s41586-018-0535-y
	5WKT	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl-β-D-Glucopyranoside	-	Gt(CT)	3.2	2017-12-13	10.1038/nprot.2017.135
	5UZ7	B1	Peptide	Calcitonin	CT	Homo sapiens	-	-	Gs/β1/γ2	4.1	2017-05-03	10.1038/nature22327
	5UZ7 (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	-	-		4.1	2017-05-03	10.1038/nature22327
	5EN0	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gt(CT)	2.81	2016-08-10	10.15252/embr.201642671
	4X1H	A	Sensory	Opsins	Rhodopsin	Bos taurus	Nonyl-β-D-Glucopyranoside	-	Gt(CT)	2.29	2015-11-04	10.1016/j.str.2015.09.015
	4J4Q	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl β-D-Glucopyranoside	-	Gt(CT)	2.65	2013-10-30	10.1002/anie.201302374
	4BEY	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	Gt(CT)	2.9	2013-05-08	10.1038/embor.2013.44
	4A4M	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gt(CT)	3.3	2012-01-25	10.1073/pnas.1114089108
	2X72	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gt(CT)	3	2011-03-16	10.1038/nature09795
	3PQR	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gt(CT)	2.85	2011-03-09	10.1038/nature09789
	3DQB	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	Gt(CT)	3.2	2008-09-23	10.1038/nature07330

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