psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:K1	L:L:N3	2.8	No	No	0	0	0
2	L:L:C2	L:L:C7	7.28	No	No	0	0	0
3	L:L:C2	R:R:Y299	4.03	No	No	0	0	7
4	L:L:N3	R:R:R362	7.23	No	Yes	0	0	4
5	L:L:T4	L:L:T6	4.71	Yes	Yes	2	0	0
6	L:L:C7	L:L:T4	5.07	No	Yes	0	0	0
7	L:L:T4	R:R:Y299	3.75	Yes	No	0	0	7
8	L:L:T4	R:R:M306	4.52	Yes	No	2	0	4
9	L:L:A5	R:R:F356	4.16	No	Yes	0	0	7
10	L:L:T6	R:R:Y234	4.99	Yes	Yes	2	0	7
11	L:L:T6	R:R:H302	10.95	Yes	Yes	0	0	6
12	L:L:T6	R:R:V305	3.17	Yes	No	2	0	7
13	L:L:T6	R:R:M306	3.01	Yes	No	2	0	4
14	L:L:T6	R:R:F356	3.89	Yes	Yes	2	0	7
15	L:L:C7	R:R:H302	7.37	No	Yes	0	0	6
16	L:L:T9	R:R:I198	3.04	No	Yes	0	0	7
17	L:L:T9	R:R:H381	6.85	No	Yes	0	0	9
18	L:L:Q10	R:R:Q227	6.4	No	No	0	0	7
19	L:L:Q10	R:R:M230	8.16	No	No	0	0	6
20	L:L:Q10	R:R:H302	7.42	No	Yes	0	0	6
21	L:L:R11	R:R:V293	3.92	No	No	0	0	6
22	L:L:L12	L:L:L16	4.15	No	Yes	0	0	0
23	L:L:L12	R:R:L148	5.54	No	Yes	4	0	5
24	L:L:L12	R:R:H377	5.14	No	No	4	0	7
25	L:L:N14	L:L:R18	6.03	No	No	0	0	0
26	L:L:N14	R:R:V293	8.87	No	No	0	0	6
27	L:L:F15	L:L:S19	9.25	Yes	No	5	0	0
28	L:L:F15	R:R:K141	8.69	Yes	No	0	0	3
29	L:L:F15	R:R:L142	3.65	Yes	Yes	5	0	2
30	L:L:F15	R:R:A145	2.77	Yes	No	0	0	4
31	L:L:L16	R:R:Y149	4.69	Yes	Yes	0	0	5
32	L:L:L16	R:R:V206	2.98	Yes	Yes	0	0	3
33	L:L:V17	R:R:V206	4.81	No	Yes	0	0	3
34	L:L:R18	R:R:D97	3.57	No	No	0	0	2
35	L:L:S19	R:R:L142	3	No	Yes	5	0	2
36	L:L:S20	R:R:L142	4.5	No	Yes	5	0	2
37	L:L:S20	R:R:Y146	7.63	No	Yes	5	0	2
38	L:L:N21	L:L:N22	9.54	No	No	0	0	0
39	L:L:N21	L:L:V26	2.96	No	No	0	0	0
40	L:L:N22	R:R:G209	5.09	No	No	0	0	3
41	L:L:L23	R:R:Y149	5.86	No	Yes	0	0	5
42	L:L:L23	R:R:P207	4.93	No	No	0	0	3
43	L:L:G24	L:L:P25	4.06	No	No	0	0	0
44	L:L:L27	L:L:P28	4.93	No	No	0	0	0
45	L:L:L27	R:R:Y41	4.69	No	No	0	0	3
46	L:L:P29	R:R:D101	4.83	No	Yes	0	0	4
47	L:L:T30	R:R:F99	12.97	No	Yes	0	0	5
48	L:L:T30	R:R:D101	8.67	No	Yes	0	0	4
49	L:L:N31	L:L:T36	10.24	No	No	0	0	0
50	L:L:V32	R:R:W79	4.9	No	Yes	0	0	6
51	L:L:V32	R:R:T132	7.93	No	No	0	0	6
52	L:L:V32	R:R:N135	10.35	No	No	0	0	3
53	L:L:S34	R:R:H121	11.16	No	Yes	6	0	4
54	L:L:S34	R:R:E123	5.75	No	No	6	0	4
55	L:L:S34	R:R:N124	10.43	No	No	6	0	5
56	L:L:T36	R:R:W79	6.06	No	Yes	0	0	6
57	L:L:?38	L:L:Y37	5.8	Yes	Yes	1	0	0
58	L:L:Y37	R:R:D77	16.09	Yes	Yes	1	0	9
59	L:L:Y37	R:R:G78	7.24	Yes	No	1	0	5
60	L:L:Y37	R:R:W79	11.58	Yes	Yes	1	0	6
61	L:L:?38	R:R:W79	2.82	Yes	Yes	1	0	6
62	L:L:?38	R:R:W128	8.46	Yes	No	0	0	5
63	L:L:?38	R:R:Y131	2.9	Yes	Yes	1	0	5
64	R:R:F99	R:R:Y41	3.09	Yes	No	1	5	3
65	R:R:P100	R:R:Y41	16.69	No	No	1	4	3
66	R:R:G44	R:R:Y98	2.9	No	Yes	0	4	4
67	R:R:M48	R:R:R45	13.65	No	No	1	6	7
68	R:R:R45	R:R:Y98	9.26	No	Yes	1	7	4
69	R:R:D97	R:R:K47	4.15	No	No	0	2	4
70	R:R:M48	R:R:Y98	9.58	No	Yes	1	6	4
71	R:R:M49	R:R:Y53	5.99	No	No	0	4	1
72	R:R:Q52	R:R:W76	19.71	No	No	0	6	8
73	R:R:C55	R:R:M59	3.24	No	No	9	9	5
74	R:R:C55	R:R:C81	7.28	No	No	9	9	9
75	R:R:Q60	R:R:Y56	12.4	No	No	0	3	3
76	R:R:D57	R:R:R58	4.76	No	No	0	4	3
77	R:R:C81	R:R:M59	3.24	No	No	9	9	5
78	R:R:L62	R:R:R74	4.86	No	Yes	0	3	4
79	R:R:P63	R:R:R74	4.32	No	Yes	0	1	4
80	R:R:A64	R:R:Y71	5.34	No	No	0	1	3
81	R:R:G67	R:R:Y65	4.35	No	No	0	2	3
82	R:R:E68	R:R:Y65	17.96	No	No	0	1	3
83	R:R:G69	R:R:P70	4.06	No	No	0	1	1
84	R:R:D84	R:R:Y71	6.9	No	No	0	4	3
85	R:R:C72	R:R:T85	3.38	Yes	Yes	1	9	7
86	R:R:C72	R:R:K110	3.23	Yes	Yes	1	9	8
87	R:R:C112	R:R:C72	5.46	No	Yes	0	9	9
88	R:R:C72	R:R:W118	6.53	Yes	Yes	1	9	9
89	R:R:D84	R:R:N73	6.73	No	No	0	4	4
90	R:R:D84	R:R:R74	26.2	No	Yes	0	4	4
91	R:R:T75	R:R:W82	3.64	No	Yes	0	5	9
92	R:R:G78	R:R:W76	5.63	No	No	0	5	8
93	R:R:D77	R:R:G78	6.71	Yes	No	1	9	5
94	R:R:D77	R:R:W79	3.35	Yes	Yes	1	9	6
95	R:R:D77	R:R:Y131	8.05	Yes	Yes	1	9	5
96	R:R:W79	R:R:Y98	6.75	Yes	Yes	1	6	4
97	R:R:F99	R:R:W79	6.01	Yes	Yes	1	5	6
98	R:R:F102	R:R:W79	7.02	Yes	Yes	1	4	6
99	R:R:W79	R:R:Y131	18.33	Yes	Yes	1	6	5
100	R:R:C81	R:R:L80	3.17	No	No	0	9	5
101	R:R:L80	R:R:P96	13.14	No	No	0	5	9
102	R:R:L80	R:R:Y131	5.86	No	Yes	0	5	5
103	R:R:V108	R:R:W82	6.13	No	Yes	1	7	9
104	R:R:K110	R:R:W82	4.64	Yes	Yes	1	8	9
105	R:R:S129	R:R:W82	7.41	No	Yes	1	7	9
106	R:R:W82	R:R:Y131	6.75	Yes	Yes	1	9	5
107	R:R:D83	R:R:Q93	3.92	No	No	0	5	6
108	R:R:S91	R:R:T85	4.8	No	Yes	0	5	7
109	R:R:K110	R:R:T85	6.01	Yes	Yes	1	8	7
110	R:R:P86	R:R:V89	12.37	No	No	0	2	5
111	R:R:L90	R:R:Y111	5.86	No	No	0	4	4
112	R:R:K107	R:R:Y92	26.27	No	No	0	3	4
113	R:R:T109	R:R:Y92	3.75	No	No	0	5	4
114	R:R:C95	R:R:P96	3.77	No	No	0	9	9
115	R:R:C95	R:R:V108	3.42	No	No	0	9	7
116	R:R:C134	R:R:C95	7.28	No	No	0	9	9
117	R:R:F99	R:R:Y98	14.44	Yes	Yes	1	5	4
118	R:R:F99	R:R:P100	4.33	Yes	No	1	5	4
119	R:R:F102	R:R:F99	7.5	Yes	Yes	1	4	5
120	R:R:D101	R:R:F102	11.94	Yes	Yes	1	4	4
121	R:R:D101	R:R:N135	10.77	Yes	No	1	4	3
122	R:R:D101	R:R:T138	2.89	Yes	No	0	4	2
123	R:R:C134	R:R:F102	4.19	No	Yes	0	9	4
124	R:R:F102	R:R:N135	3.62	Yes	No	1	4	3
125	R:R:D103	R:R:P104	9.66	Yes	No	0	3	3
126	R:R:D103	R:R:S105	4.42	Yes	No	0	3	1
127	R:R:D103	R:R:K141	8.3	Yes	No	0	3	3
128	R:R:V108	R:R:Y131	12.62	No	Yes	1	7	5
129	R:R:N130	R:R:T109	5.85	No	No	0	8	5
130	R:R:K110	R:R:W118	4.64	Yes	Yes	1	8	9
131	R:R:E114	R:R:Y111	11.22	No	No	0	2	4
132	R:R:F119	R:R:Y111	23.73	No	No	0	4	4
133	R:R:D113	R:R:E114	5.2	No	No	0	5	2
134	R:R:D113	R:R:K115	2.77	No	No	0	5	5
135	R:R:D113	R:R:V117	10.22	No	No	0	5	5
136	R:R:F119	R:R:P122	5.78	No	No	0	4	5
137	R:R:H121	R:R:P122	7.63	Yes	No	0	4	5
138	R:R:E123	R:R:H121	8.62	No	Yes	6	4	4
139	R:R:H121	R:R:N124	6.38	Yes	No	6	4	5
140	R:R:H121	R:R:W128	17.98	Yes	No	0	4	5
141	R:R:N124	R:R:R126	4.82	No	No	0	5	4
142	R:R:N130	R:R:W128	7.91	No	No	0	8	5
143	R:R:S129	R:R:Y131	6.36	No	Yes	1	7	5
144	R:R:A136	R:R:F137	2.77	No	No	0	2	1
145	R:R:F137	R:R:K366	4.96	No	No	0	1	3
146	R:R:P139	R:R:T138	3.5	No	No	0	3	2
147	R:R:E140	R:R:N144	6.57	No	Yes	0	2	4
148	R:R:K141	R:R:K366	2.87	No	No	0	3	3
149	R:R:L142	R:R:Y146	8.21	Yes	Yes	5	2	2
150	R:R:K143	R:R:N144	4.2	No	Yes	0	1	4
151	R:R:K370	R:R:N144	6.99	No	Yes	4	4	4
152	R:R:N144	R:R:Y374	4.65	Yes	Yes	4	4	6
153	R:R:V147	R:R:Y374	7.57	No	Yes	0	4	6
154	R:R:D373	R:R:L148	4.07	No	Yes	0	5	5
155	R:R:H377	R:R:L148	15.43	No	Yes	4	7	5
156	R:R:Y149	R:R:Y150	7.94	Yes	No	0	5	4
157	R:R:L202	R:R:Y149	4.69	No	Yes	0	7	5
158	R:R:L151	R:R:S378	4.5	No	No	0	5	5
159	R:R:F382	R:R:L151	4.87	No	No	0	7	5
160	R:R:A152	R:R:H381	7.32	No	Yes	0	7	9
161	R:R:I153	R:R:I199	2.94	No	No	0	7	7
162	R:R:I153	R:R:V203	3.07	No	No	0	7	3
163	R:R:F382	R:R:G155	9.03	No	No	0	7	8
164	R:R:H156	R:R:S195	11.16	Yes	No	0	7	7
165	R:R:H156	R:R:I198	17.23	Yes	Yes	0	7	7
166	R:R:H156	R:R:H381	9.55	Yes	Yes	0	7	9
167	R:R:L158	R:R:T162	2.95	No	No	10	4	6
168	R:R:F385	R:R:L158	12.18	Yes	No	10	5	4
169	R:R:S159	R:R:S195	6.52	No	No	0	9	7
170	R:R:I160	R:R:S195	3.1	No	No	0	5	7
171	R:R:I160	R:R:M196	5.83	No	No	0	5	4
172	R:R:F161	R:R:I165	3.77	No	No	0	4	5
173	R:R:F385	R:R:T162	7.78	Yes	No	10	5	6
174	R:R:L163	R:R:S166	3	Yes	No	0	8	9
175	R:R:F188	R:R:L163	8.53	Yes	Yes	0	8	8
176	R:R:L163	R:R:Y191	3.52	Yes	Yes	0	8	8
177	R:R:I192	R:R:L163	5.71	Yes	Yes	0	7	8
178	R:R:A388	R:R:L163	3.15	No	Yes	0	8	8
179	R:R:I165	R:R:I169	2.94	No	No	0	5	8
180	R:R:C392	R:R:S166	6.89	No	No	0	9	9
181	R:R:F172	R:R:G168	3.01	No	No	0	2	1
182	R:R:F173	R:R:I169	6.28	Yes	No	0	7	8
183	R:R:F170	R:R:V181	9.18	Yes	No	0	8	9
184	R:R:F170	R:R:K185	4.96	Yes	No	0	8	6
185	R:R:F170	R:R:F188	6.43	Yes	Yes	0	8	8
186	R:R:C392	R:R:F170	4.19	No	Yes	0	9	8
187	R:R:F172	R:R:V171	3.93	No	No	0	2	4
188	R:R:F173	R:R:T401	5.19	Yes	Yes	0	7	7
189	R:R:F173	R:R:Q405	11.71	Yes	No	0	7	4
190	R:R:L176	R:R:S175	3	No	No	12	9	8
191	R:R:S175	R:R:T401	4.8	No	Yes	12	8	7
192	R:R:L176	R:R:V398	4.47	No	No	0	9	9
193	R:R:L176	R:R:T401	7.37	No	Yes	12	9	7
194	R:R:C178	R:R:R180	4.18	No	Yes	11	8	9
195	R:R:C178	R:R:V181	3.42	No	No	11	8	9
196	R:R:Q179	R:R:Y243	5.64	No	Yes	0	7	8
197	R:R:R180	R:R:V181	3.92	Yes	No	11	9	9
198	R:R:H184	R:R:R180	6.77	Yes	Yes	0	9	9
199	R:R:N395	R:R:R180	4.82	No	Yes	0	9	9
200	R:R:E397	R:R:R180	3.49	No	Yes	0	9	9
201	R:R:L183	R:R:W236	4.56	No	Yes	0	8	9
202	R:R:E240	R:R:L183	5.3	No	No	0	9	8
203	R:R:L183	R:R:Y243	5.86	No	Yes	0	8	8
204	R:R:F188	R:R:H184	3.39	Yes	Yes	0	8	9
205	R:R:E240	R:R:H184	8.62	No	Yes	0	9	9
206	R:R:H184	R:R:Y391	8.71	Yes	No	0	9	8
207	R:R:N186	R:R:W236	9.04	No	Yes	2	9	9
208	R:R:N186	R:R:Y263	5.81	No	Yes	2	9	5
209	R:R:M187	R:R:Y191	4.79	No	Yes	2	8	8
210	R:R:M187	R:R:N233	2.8	No	Yes	2	8	9
211	R:R:F188	R:R:V387	5.24	Yes	No	0	8	9
212	R:R:L189	R:R:L193	2.77	No	No	0	3	6
213	R:R:N233	R:R:T190	2.92	Yes	No	2	9	9
214	R:R:T190	R:R:W236	3.64	No	Yes	2	9	9
215	R:R:T190	R:R:W267	4.85	No	No	2	9	9
216	R:R:N233	R:R:Y191	11.63	Yes	Yes	2	9	8
217	R:R:M237	R:R:Y191	3.59	Yes	Yes	2	9	8
218	R:R:Q383	R:R:Y191	10.15	Yes	Yes	2	9	8
219	R:R:G384	R:R:Y191	5.79	No	Yes	0	9	8
220	R:R:V387	R:R:Y191	6.31	No	Yes	0	9	8
221	R:R:I192	R:R:M196	2.92	Yes	No	0	7	4
222	R:R:L193	R:R:M229	9.9	No	No	0	6	4
223	R:R:I198	R:R:N194	5.66	Yes	No	0	7	8
224	R:R:N194	R:R:N233	4.09	No	Yes	0	8	9
225	R:R:I197	R:R:L222	2.85	No	No	0	5	6
226	R:R:H226	R:R:I197	3.98	No	No	0	6	5
227	R:R:I198	R:R:L202	2.85	Yes	No	0	7	7
228	R:R:H226	R:R:I198	6.63	No	Yes	0	6	7
229	R:R:E204	R:R:I200	2.73	No	No	0	4	6
230	R:R:I200	R:R:L222	2.85	No	No	0	6	6
231	R:R:H201	R:R:V205	9.69	Yes	No	0	6	7
232	R:R:H201	R:R:V206	2.77	Yes	Yes	0	6	3
233	R:R:H201	R:R:L222	5.14	Yes	No	0	6	6
234	R:R:H201	R:R:L291	7.71	Yes	No	0	6	6
235	R:R:L202	R:R:V206	2.98	No	Yes	0	7	3
236	R:R:P207	R:R:V206	3.53	No	Yes	0	3	3
237	R:R:L211	R:R:N208	5.49	No	No	0	1	3
238	R:R:E210	R:R:R214	4.65	No	No	0	3	4
239	R:R:L211	R:R:P216	4.93	No	No	14	1	4
240	R:R:C219	R:R:L211	3.17	No	No	14	9	1
241	R:R:C289	R:R:V212	5.12	No	No	0	9	3
242	R:R:P216	R:R:R214	4.32	No	No	0	4	4
243	R:R:D215	R:R:K220	6.91	No	No	0	6	7
244	R:R:D215	R:R:N288	13.46	No	No	0	6	4
245	R:R:C219	R:R:P216	5.65	No	No	14	9	4
246	R:R:C219	R:R:C289	7.28	No	No	0	9	9
247	R:R:K220	R:R:N286	5.6	No	No	3	7	7
248	R:R:K220	R:R:W290	26.69	No	Yes	3	7	9
249	R:R:H223	R:R:Q227	14.84	No	No	0	5	7
250	R:R:H223	R:R:W290	3.17	No	Yes	0	5	9
251	R:R:F224	R:R:T274	3.89	No	No	0	5	6
252	R:R:A278	R:R:F224	2.77	No	No	0	6	5
253	R:R:H226	R:R:M230	3.94	No	No	0	6	6
254	R:R:I301	R:R:Q227	5.49	Yes	No	0	7	7
255	R:R:L271	R:R:Y228	4.69	No	No	0	4	8
256	R:R:T274	R:R:Y228	3.75	No	No	0	6	8
257	R:R:M230	R:R:Y234	4.79	No	Yes	0	6	7
258	R:R:C232	R:R:W267	6.53	No	No	0	8	9
259	R:R:C232	R:R:P270	3.77	No	Yes	0	8	9
260	R:R:M237	R:R:N233	4.21	Yes	Yes	2	9	9
261	R:R:M237	R:R:Y234	4.79	Yes	Yes	2	9	7
262	R:R:V305	R:R:Y234	8.83	No	Yes	2	7	7
263	R:R:F356	R:R:Y234	11.35	Yes	Yes	2	7	7
264	R:R:F235	R:R:L265	3.65	Yes	Yes	7	5	7
265	R:R:F235	R:R:F269	8.57	Yes	No	7	5	3
266	R:R:F235	R:R:P270	5.78	Yes	Yes	7	5	9
267	R:R:A308	R:R:F235	2.77	No	Yes	0	7	5
268	R:R:C239	R:R:W236	3.92	No	Yes	0	7	9
269	R:R:W236	R:R:Y263	3.86	Yes	Yes	2	9	5
270	R:R:G266	R:R:W236	7.04	No	Yes	0	9	9
271	R:R:W236	R:R:W267	13.12	Yes	No	2	9	9
272	R:R:M237	R:R:Q383	5.44	Yes	Yes	2	9	9
273	R:R:I242	R:R:L238	2.85	No	Yes	0	7	8
274	R:R:L238	R:R:L265	2.77	Yes	Yes	0	8	7
275	R:R:L238	R:R:V311	2.98	Yes	No	0	8	6
276	R:R:L238	R:R:N312	10.98	Yes	No	0	8	9
277	R:R:C239	R:R:L265	4.76	No	Yes	0	7	7
278	R:R:E240	R:R:L351	10.6	No	No	0	9	9
279	R:R:I242	R:R:Y262	4.84	No	No	0	7	7
280	R:R:F315	R:R:I242	5.02	No	No	0	8	7
281	R:R:L247	R:R:Y243	7.03	No	Yes	0	8	8
282	R:R:Q257	R:R:Y243	3.38	Yes	Yes	13	5	8
283	R:R:Y243	R:R:Y262	7.94	Yes	No	13	8	7
284	R:R:I248	R:R:L244	2.85	No	No	0	7	9
285	R:R:I319	R:R:L244	4.28	No	No	0	9	9
286	R:R:L244	R:R:L348	2.77	No	No	0	9	9
287	R:R:H245	R:R:V249	12.45	Yes	No	15	8	6
288	R:R:H245	R:R:V250	2.77	Yes	No	0	8	5
289	R:R:F315	R:R:H245	21.5	No	Yes	0	8	8
290	R:R:H245	R:R:N318	5.1	Yes	No	15	8	8
291	R:R:Q257	R:R:T246	9.92	Yes	No	0	5	7
292	R:R:I248	R:R:L247	2.85	No	No	0	7	8
293	R:R:I248	R:R:V322	3.07	No	No	0	7	8
294	R:R:N318	R:R:V249	4.43	No	No	15	8	6
295	R:R:A251	R:R:T254	5.03	No	No	0	6	6
296	R:R:Q257	R:R:Y262	5.64	Yes	No	13	5	7
297	R:R:R258	R:R:W261	11	No	No	0	5	2
298	R:R:L259	R:R:Y263	7.03	No	Yes	0	5	5
299	R:R:R260	R:R:Y263	3.09	No	Yes	0	3	5
300	R:R:F269	R:R:L265	4.87	No	Yes	7	3	7
301	R:R:F269	R:R:P270	4.33	No	Yes	7	3	9
302	R:R:P273	R:R:V272	3.53	No	No	0	6	4
303	R:R:I301	R:R:P273	3.39	Yes	No	0	7	6
304	R:R:I301	R:R:T274	6.08	Yes	No	0	7	6
305	R:R:I276	R:R:I300	2.94	No	No	0	5	8
306	R:R:H277	R:R:R281	11.28	Yes	Yes	3	7	7
307	R:R:H277	R:R:L298	5.14	Yes	Yes	3	7	6
308	R:R:H277	R:R:I301	10.61	Yes	Yes	0	7	7
309	R:R:L297	R:R:T280	2.95	No	No	0	4	4
310	R:R:R281	R:R:W290	15.99	Yes	Yes	3	7	9
311	R:R:R281	R:R:S292	3.95	Yes	Yes	3	7	4
312	R:R:R281	R:R:T295	3.88	Yes	Yes	3	7	4
313	R:R:L298	R:R:R281	8.5	Yes	Yes	3	6	7
314	R:R:V283	R:R:Y284	10.09	No	No	0	3	2
315	R:R:F285	R:R:S292	6.61	No	Yes	3	6	4
316	R:R:E294	R:R:F285	4.66	No	No	3	3	6
317	R:R:F285	R:R:T295	12.97	No	Yes	3	6	4
318	R:R:N286	R:R:W290	7.91	No	Yes	3	7	9
319	R:R:D287	R:R:S292	5.89	No	Yes	0	3	4
320	R:R:C289	R:R:L291	3.17	No	No	0	9	6
321	R:R:E294	R:R:S292	10.06	No	Yes	3	3	4
322	R:R:S292	R:R:T295	3.2	Yes	Yes	3	4	4
323	R:R:L298	R:R:V293	2.98	Yes	No	0	6	6
324	R:R:L297	R:R:T295	4.42	No	Yes	0	4	4
325	R:R:H302	R:R:L298	5.14	Yes	Yes	0	6	6
326	R:R:G303	R:R:P304	4.06	No	No	0	4	9
327	R:R:F356	R:R:L309	3.65	Yes	No	0	7	7
328	R:R:F314	R:R:V310	3.93	No	No	0	5	4
329	R:R:F315	R:R:V311	5.24	No	No	0	8	6
330	R:R:L352	R:R:N312	2.75	Yes	No	0	9	9
331	R:R:F313	R:R:L317	8.53	Yes	No	0	6	5
332	R:R:F313	R:R:V357	3.93	Yes	No	0	6	7
333	R:R:L316	R:R:L348	2.77	No	No	0	9	9
334	R:R:I354	R:R:L316	7.14	No	No	0	6	9
335	R:R:K326	R:R:V322	3.04	No	No	0	9	8
336	R:R:E332	R:R:M327	6.77	No	Yes	0	5	7
337	R:R:M327	R:R:M337	7.22	Yes	No	0	7	7
338	R:R:K340	R:R:M327	7.2	No	Yes	0	8	7
339	R:R:E332	R:R:T330	2.82	No	No	0	5	5
340	R:R:E332	R:R:H336	9.85	No	No	0	5	6
341	R:R:E334	R:R:M337	5.41	No	No	0	6	7
342	R:R:E334	R:R:Y338	14.59	No	No	0	6	7
343	R:R:H336	R:R:K340	7.86	No	No	0	6	8
344	R:R:M346	R:R:V342	3.04	No	No	0	8	8
345	R:R:I347	R:R:I390	5.89	No	No	0	8	8
346	R:R:P350	R:R:V349	3.53	No	Yes	0	9	8
347	R:R:I354	R:R:V349	9.22	No	Yes	0	6	8
348	R:R:Q355	R:R:V349	4.3	Yes	Yes	0	8	8
349	R:R:F386	R:R:P350	2.89	No	No	0	5	9
350	R:R:L351	R:R:L352	4.15	No	Yes	0	9	9
351	R:R:L351	R:R:Y391	15.24	No	No	0	9	8
352	R:R:I354	R:R:L352	4.28	No	Yes	0	6	9
353	R:R:G353	R:R:Q355	4.93	No	Yes	2	9	8
354	R:R:F356	R:R:G353	3.01	Yes	No	2	7	9
355	R:R:F356	R:R:Q355	11.71	Yes	Yes	2	7	8
356	R:R:L379	R:R:Q355	5.32	No	Yes	0	5	8
357	R:R:Q355	R:R:Q383	7.68	Yes	Yes	2	8	9
358	R:R:F356	R:R:I380	6.28	Yes	Yes	0	7	6
359	R:R:F356	R:R:Q383	3.51	Yes	Yes	2	7	9
360	R:R:F359	R:R:V358	7.87	No	No	0	6	5
361	R:R:F359	R:R:W361	6.01	No	No	0	6	4
362	R:R:F359	R:R:M376	3.73	No	No	0	6	7
363	R:R:P360	R:R:W361	5.4	No	No	0	5	4
364	R:R:P363	R:R:W361	6.76	Yes	No	0	7	4
365	R:R:P363	R:R:R362	5.76	Yes	Yes	8	7	4
366	R:R:G369	R:R:R362	4.5	No	Yes	0	4	4
367	R:R:R362	R:R:Y372	4.12	Yes	No	8	4	7
368	R:R:D373	R:R:R362	9.53	No	Yes	0	5	4
369	R:R:L368	R:R:P363	4.93	No	Yes	0	3	7
370	R:R:P363	R:R:Y372	8.34	Yes	No	8	7	7
371	R:R:L368	R:R:N365	6.87	No	No	0	3	4
372	R:R:K370	R:R:M367	2.88	No	No	0	4	4
373	R:R:K370	R:R:Y374	8.36	No	Yes	4	4	6
374	R:R:M376	R:R:Y372	8.38	No	No	0	7	7
375	R:R:I380	R:R:M376	2.92	Yes	No	0	6	7
376	R:R:H377	R:R:H381	9.55	No	Yes	0	7	9
377	R:R:H381	R:R:I380	3.98	Yes	Yes	0	9	6
378	R:R:F385	R:R:F386	4.29	Yes	No	0	5	5
379	R:R:F385	R:R:T389	7.78	Yes	No	0	5	5
380	R:R:I390	R:R:Y391	7.25	No	No	0	8	8
381	R:R:C392	R:R:F393	4.19	No	No	0	9	8
382	R:R:N395	R:R:V398	5.91	No	No	0	9	9
383	R:R:F409	R:R:W406	3.01	No	No	0	3	6
384	R:R:M49	R:R:Q52	2.72	No	No	0	4	6
385	R:R:E106	R:R:M133	2.71	No	No	0	4	5
386	R:R:K256	R:R:Q179	2.71	No	No	0	5	7
387	R:R:E329	R:R:K326	2.7	No	No	0	6	9
388	R:R:H156	R:R:I199	2.65	Yes	No	0	7	7
389	R:R:H277	R:R:I300	2.65	Yes	No	0	7	8
390	R:R:F382	R:R:V154	2.62	No	No	0	7	6
391	R:R:F173	R:R:V402	2.62	Yes	No	0	7	5
392	R:R:F313	R:R:V358	2.62	Yes	No	0	6	5
393	R:R:D103	R:R:E106	2.6	Yes	No	0	3	4
394	R:R:H381	R:R:L151	2.57	Yes	No	0	9	5
395	R:R:D83	R:R:R74	2.38	No	Yes	0	5	4
396	L:L:L16	R:R:Y146	2.34	Yes	Yes	0	0	2
397	L:L:L23	R:R:Y146	2.34	No	Yes	0	0	2
398	R:R:Q61	R:R:R58	2.34	No	No	0	3	3
399	R:R:L148	R:R:Y374	2.34	Yes	Yes	4	5	6
400	R:R:K120	R:R:W118	2.32	No	Yes	0	1	9
401	R:R:N73	R:R:W118	2.26	No	Yes	0	4	9
402	R:R:H296	R:R:Y299	2.18	No	No	0	2	7
403	R:R:F224	R:R:F225	2.14	No	No	0	5	5
404	R:R:F313	R:R:F314	2.14	Yes	No	0	6	5
405	R:R:G268	R:R:P270	2.03	No	Yes	0	6	9
406	R:R:Y65	R:R:Y71	1.99	No	No	0	3	3
407	R:R:C112	R:R:G88	1.96	No	No	0	9	8
408	R:R:A87	R:R:G116	1.95	No	No	0	4	9
409	R:R:A87	R:R:P70	1.87	No	No	0	4	1
410	R:R:A231	R:R:P270	1.87	No	Yes	0	5	9
411	R:R:G116	R:R:V117	1.84	No	No	0	9	5
412	R:R:G209	R:R:V212	1.84	No	No	0	3	3
413	R:R:P86	R:R:T85	1.75	No	Yes	0	2	7
414	R:R:G44	R:R:K47	1.74	No	No	0	4	4
415	R:R:G241	R:R:L352	1.71	No	Yes	0	8	9
416	R:R:G268	R:R:L264	1.71	No	No	0	6	3
417	L:L:A13	R:R:V206	1.7	No	Yes	0	0	3
418	L:L:G33	L:L:N31	1.7	No	No	0	0	0
419	R:R:A341	R:R:V320	1.7	No	No	0	9	7
420	R:R:A341	R:R:V324	1.7	No	No	0	9	5
421	R:R:C394	R:R:T389	1.69	No	No	0	5	5
422	L:L:A8	R:R:I380	1.62	No	Yes	0	0	6
423	R:R:T345	R:R:V320	1.59	No	No	0	9	7
424	R:R:T345	R:R:V349	1.59	No	Yes	0	9	8
425	R:R:P63	R:R:Q61	1.58	No	No	0	1	3
426	R:R:A344	R:R:L323	1.58	No	No	0	9	9
427	R:R:T400	R:R:T401	1.57	No	Yes	0	4	7
428	R:R:I160	R:R:V164	1.54	No	No	0	5	4
429	R:R:I165	R:R:V164	1.54	No	No	0	5	4
430	R:R:I192	R:R:V164	1.54	Yes	No	0	7	4
431	R:R:I371	R:R:V375	1.54	No	No	0	5	4
432	R:R:K46	R:R:V42	1.52	No	No	0	4	1
433	R:R:K46	R:R:V43	1.52	No	No	0	4	2
434	R:R:K185	R:R:V171	1.52	No	No	0	6	4
435	R:R:I276	R:R:T275	1.52	No	No	0	5	3
436	R:R:I279	R:R:T280	1.52	No	No	0	3	4
437	R:R:M337	R:R:V324	1.52	No	No	0	7	5
438	R:R:L379	R:R:V375	1.49	No	No	0	5	4
439	R:R:L259	R:R:T182	1.47	No	No	0	5	5
440	L:L:N35	L:L:T36	1.46	No	No	0	0	0
441	R:R:A333	R:R:H336	1.46	No	No	0	5	6
442	R:R:I192	R:R:L167	1.43	Yes	No	0	7	6
443	R:R:Q257	R:R:T254	1.42	Yes	No	0	5	6
444	R:R:L323	R:R:M327	1.41	No	Yes	0	9	7
445	R:R:K343	R:R:L339	1.41	No	No	0	8	6
446	R:R:M229	R:R:N194	1.4	No	No	0	4	8
447	R:R:D50	R:R:K54	1.38	No	No	0	2	4
448	R:R:N396	R:R:Q399	1.32	No	No	0	6	7
449	R:R:R404	R:R:T401	1.29	No	Yes	0	7	7
450	R:R:E255	R:R:Q179	1.27	No	No	0	6	7
451	R:R:N125	R:R:R126	1.21	No	No	0	7	4
452	R:R:M59	R:R:Y56	1.2	No	No	0	5	3
453	R:R:L297	R:R:Y284	1.17	No	No	0	4	2

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:T4	4.5125	4	2	0
2	L:L:T6	5.12	6	2	0
3	L:L:F15	6.09	4	5	0
4	L:L:L16	3.54	4	0	0
5	L:L:Y37	10.1775	4	1	0
6	L:L:?38	4.995	4	1	0
7	R:R:C72	4.65	4	1	9
8	R:R:R74	9.44	4	0	4
9	R:R:D77	8.55	4	1	9
10	R:R:W79	7.42444	9	1	6
11	R:R:W82	5.714	5	1	9
12	R:R:T85	3.985	4	1	7
13	R:R:Y98	8.586	5	1	4
14	R:R:F99	8.05667	6	1	5
15	R:R:D101	7.82	5	1	4
16	R:R:F102	6.854	5	1	4
17	R:R:D103	6.245	4	0	3
18	R:R:K110	4.63	4	1	8
19	R:R:W118	3.9375	4	1	9
20	R:R:H121	10.354	5	6	4
21	R:R:Y131	8.69571	7	1	5
22	R:R:L142	4.84	4	5	2
23	R:R:N144	5.6025	4	4	4
24	R:R:Y146	5.13	4	5	2
25	R:R:L148	6.845	4	4	5
26	R:R:Y149	5.795	4	0	5
27	R:R:H156	10.1475	4	0	7
28	R:R:L163	4.782	5	0	8
29	R:R:F170	6.19	4	0	8
30	R:R:F173	6.45	4	0	7
31	R:R:R180	4.636	5	11	9
32	R:R:H184	6.8725	4	0	9
33	R:R:F188	5.8975	4	0	8
34	R:R:Y191	6.54	7	2	8
35	R:R:I192	2.9	4	0	7
36	R:R:I198	7.082	5	0	7
37	R:R:H201	6.3275	4	0	6
38	R:R:V206	3.12833	6	0	3
39	R:R:N233	5.13	5	2	9
40	R:R:Y234	6.95	5	2	7
41	R:R:F235	5.1925	4	7	5
42	R:R:W236	6.45429	7	2	9
43	R:R:M237	4.5075	4	2	9
44	R:R:L238	4.895	4	0	8
45	R:R:Y243	5.97	5	13	8
46	R:R:H245	10.455	4	15	8
47	R:R:Q257	5.09	4	13	5
48	R:R:Y263	4.9475	4	2	5
49	R:R:L265	4.0125	4	7	7
50	R:R:P270	3.556	5	7	9
51	R:R:H277	7.42	4	3	7
52	R:R:R281	8.72	5	3	7
53	R:R:W290	13.44	4	3	9
54	R:R:S292	5.942	5	3	4
55	R:R:T295	6.1175	4	3	4
56	R:R:L298	5.44	4	3	6
57	R:R:I301	6.3925	4	0	7
58	R:R:H302	7.72	4	0	6
59	R:R:F313	4.305	4	0	6
60	R:R:M327	5.65	4	0	7
61	R:R:V349	4.66	4	0	8
62	R:R:L352	3.2225	4	0	9
63	R:R:Q355	6.788	5	2	8
64	R:R:F356	5.945	8	2	7
65	R:R:R362	6.228	5	8	4
66	R:R:P363	6.4475	4	8	7
67	R:R:Y374	5.73	4	4	6
68	R:R:I380	3.7	4	0	6
69	R:R:H381	6.63667	6	0	9
70	R:R:Q383	6.695	4	2	9
71	R:R:F385	8.0075	4	10	5
72	R:R:T401	4.044	5	12	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:T6	R:R:F356	54.5639	3.89	Yes	Yes	2	0	7
2	R:R:F356	R:R:I380	34.7696	6.28	Yes	Yes	0	7	6
3	R:R:I380	R:R:M376	16.7025	2.92	Yes	No	0	6	7
4	L:L:T6	R:R:H302	79.9108	10.95	Yes	Yes	0	0	6
5	R:R:H381	R:R:I380	22.8416	3.98	Yes	Yes	0	9	6
6	R:R:H377	R:R:H381	17.049	9.55	No	Yes	0	7	9
7	R:R:H156	R:R:I198	10.3076	17.23	Yes	Yes	0	7	7
8	L:L:Q10	R:R:H302	24.6824	7.42	No	Yes	0	0	6
9	L:L:Q10	R:R:M230	32.0102	8.16	No	No	0	0	6
10	L:L:Q10	R:R:Q227	11.9956	6.4	No	No	0	0	7
11	R:R:H302	R:R:L298	100	5.14	Yes	Yes	0	6	6
12	R:R:L298	R:R:V293	90.5613	2.98	Yes	No	0	6	6
13	L:L:N14	R:R:V293	89.4348	8.87	No	No	0	0	6
14	L:L:N14	L:L:R18	88.8662	6.03	No	No	0	0	0
15	L:L:F15	R:R:L142	23.1401	3.65	Yes	Yes	5	0	2
16	R:R:L142	R:R:Y146	27.3015	8.21	Yes	Yes	5	2	2
17	L:L:L16	R:R:Y146	23.5363	2.34	Yes	Yes	0	0	2
18	L:L:F15	R:R:K141	18.9804	8.69	Yes	No	0	0	3
19	L:L:L16	R:R:V206	11.0201	2.98	Yes	Yes	0	0	3
20	L:L:R18	R:R:D97	88.2798	3.57	No	No	0	0	2
21	R:R:H201	R:R:L291	10.5315	7.71	Yes	No	0	6	6
22	R:R:D97	R:R:K47	87.7361	4.15	No	No	0	2	4
23	R:R:G44	R:R:K47	87.1568	1.74	No	No	0	4	4
24	R:R:G44	R:R:Y98	86.574	2.9	No	Yes	0	4	4
25	R:R:F99	R:R:Y98	14.1669	14.44	Yes	Yes	1	5	4
26	R:R:W79	R:R:Y98	70.6356	6.75	Yes	Yes	1	6	4
27	L:L:?38	R:R:W79	19.7463	2.82	Yes	Yes	1	0	6
28	L:L:?38	R:R:W128	20.8799	8.46	Yes	No	0	0	5
29	R:R:H121	R:R:W128	16.5337	17.98	Yes	No	0	4	5
30	R:R:W79	R:R:Y131	31.2408	18.33	Yes	Yes	1	6	5
31	R:R:W82	R:R:Y131	24.1618	6.75	Yes	Yes	1	9	5
32	R:R:K110	R:R:W82	22.6976	4.64	Yes	Yes	1	8	9
33	R:R:K110	R:R:W118	15.5849	4.64	Yes	Yes	1	8	9
34	R:R:N73	R:R:W118	13.991	2.26	No	Yes	0	4	9
35	R:R:D84	R:R:N73	13.083	6.73	No	No	0	4	4
36	R:R:H121	R:R:P122	11.1498	7.63	Yes	No	0	4	5
37	R:R:F119	R:R:P122	10.2401	5.78	No	No	0	4	5
38	R:R:D103	R:R:K141	10.5794	8.3	Yes	No	0	3	3
39	R:R:L202	R:R:Y149	19.4868	4.69	No	Yes	0	7	5
40	R:R:L202	R:R:V206	17.1183	2.98	No	Yes	0	7	3
41	R:R:F356	R:R:Q355	29.1281	11.71	Yes	Yes	2	7	8
42	R:R:Q355	R:R:V349	32.0013	4.3	Yes	Yes	0	8	8
43	R:R:I165	R:R:V164	10.4444	1.54	No	No	0	5	4
44	R:R:F356	R:R:Q383	23.9841	3.51	Yes	Yes	2	7	9
45	R:R:Q383	R:R:Y191	26.0754	10.15	Yes	Yes	2	9	8
46	R:R:L163	R:R:Y191	31.0098	3.52	Yes	Yes	0	8	8
47	R:R:F188	R:R:L163	17.7882	8.53	Yes	Yes	0	8	8
48	R:R:V387	R:R:Y191	17.2018	6.31	No	Yes	0	9	8
49	R:R:F188	R:R:V387	16.3987	5.24	Yes	No	0	8	9
50	R:R:I192	R:R:L163	11.6509	5.71	Yes	Yes	0	7	8
51	R:R:F170	R:R:F188	13.3656	6.43	Yes	Yes	0	8	8
52	R:R:F188	R:R:H184	20.6311	3.39	Yes	Yes	0	8	9
53	R:R:H184	R:R:R180	13.4242	6.77	Yes	Yes	0	9	9
54	R:R:M237	R:R:Y234	33.97	4.79	Yes	Yes	2	9	7
55	R:R:M237	R:R:N233	17.4044	4.21	Yes	Yes	2	9	9
56	R:R:N233	R:R:T190	29.4781	2.92	Yes	No	2	9	9
57	R:R:T190	R:R:W236	22.0686	3.64	No	Yes	2	9	9
58	R:R:L183	R:R:W236	12.1751	4.56	No	Yes	0	8	9
59	R:R:L183	R:R:Y243	11.5532	5.86	No	Yes	0	8	8
60	R:R:N233	R:R:Y191	11.045	11.63	Yes	Yes	2	9	8
61	R:R:I354	R:R:V349	18.0973	9.22	No	Yes	0	6	8
62	R:R:I354	R:R:L352	13.4828	4.28	No	Yes	0	6	9
63	R:R:I198	R:R:N194	21.532	5.66	Yes	No	0	7	8
64	R:R:H226	R:R:M230	29.5457	3.94	No	No	0	6	6
65	R:R:H226	R:R:I198	23.3142	6.63	No	Yes	0	6	7
66	R:R:L298	R:R:R281	14.8084	8.5	Yes	Yes	3	6	7
67	R:R:T345	R:R:V349	15.0713	1.59	No	Yes	0	9	8
68	R:R:T345	R:R:V320	14.2131	1.59	No	No	0	9	7
69	R:R:A341	R:R:V320	13.3513	1.7	No	No	0	9	7
70	R:R:A341	R:R:V324	12.486	1.7	No	No	0	9	5
71	R:R:M337	R:R:V324	11.6171	1.52	No	No	0	7	5
72	L:L:T6	R:R:Y234	28.2894	4.99	Yes	Yes	2	0	7
73	R:R:I198	R:R:L202	37.227	2.85	Yes	No	0	7	7
74	R:R:M237	R:R:Y191	19.5277	3.59	Yes	Yes	2	9	8
75	R:R:N194	R:R:N233	21.6457	4.09	No	Yes	0	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:C2	R:R:Y299	4.03	0	No	No	0	7	0	1
L:L:N3	R:R:R362	7.23	0	No	Yes	0	4	0	1
L:L:T4	R:R:Y299	3.75	2	Yes	No	0	7	0	1
L:L:T4	R:R:M306	4.52	2	Yes	No	0	4	0	1
L:L:A5	R:R:F356	4.16	0	No	Yes	0	7	0	1
L:L:T6	R:R:Y234	4.99	2	Yes	Yes	0	7	0	1
L:L:T6	R:R:H302	10.95	2	Yes	Yes	0	6	0	1
L:L:T6	R:R:V305	3.17	2	Yes	No	0	7	0	1
L:L:T6	R:R:M306	3.01	2	Yes	No	0	4	0	1
L:L:T6	R:R:F356	3.89	2	Yes	Yes	0	7	0	1
L:L:C7	R:R:H302	7.37	0	No	Yes	0	6	0	1
L:L:T9	R:R:I198	3.04	0	No	Yes	0	7	0	1
L:L:T9	R:R:H381	6.85	0	No	Yes	0	9	0	1
L:L:Q10	R:R:Q227	6.4	0	No	No	0	7	0	1
L:L:Q10	R:R:M230	8.16	0	No	No	0	6	0	1
L:L:Q10	R:R:H302	7.42	0	No	Yes	0	6	0	1
L:L:R11	R:R:V293	3.92	0	No	No	0	6	0	1
L:L:L12	R:R:L148	5.54	4	No	Yes	0	5	0	1
L:L:L12	R:R:H377	5.14	4	No	No	0	7	0	1
L:L:N14	R:R:V293	8.87	0	No	No	0	6	0	1
L:L:F15	R:R:K141	8.69	5	Yes	No	0	3	0	1
L:L:F15	R:R:L142	3.65	5	Yes	Yes	0	2	0	1
L:L:F15	R:R:A145	2.77	5	Yes	No	0	4	0	1
L:L:L16	R:R:Y149	4.69	0	Yes	Yes	0	5	0	1
L:L:L16	R:R:V206	2.98	0	Yes	Yes	0	3	0	1
L:L:V17	R:R:V206	4.81	0	No	Yes	0	3	0	1
L:L:R18	R:R:D97	3.57	0	No	No	0	2	0	1
L:L:S19	R:R:L142	3	5	No	Yes	0	2	0	1
L:L:S20	R:R:L142	4.5	5	No	Yes	0	2	0	1
L:L:S20	R:R:Y146	7.63	5	No	Yes	0	2	0	1
L:L:N22	R:R:G209	5.09	0	No	No	0	3	0	1
L:L:L23	R:R:Y149	5.86	0	No	Yes	0	5	0	1
L:L:L23	R:R:P207	4.93	0	No	No	0	3	0	1
L:L:L27	R:R:Y41	4.69	0	No	No	0	3	0	1
L:L:P29	R:R:D101	4.83	0	No	Yes	0	4	0	1
L:L:T30	R:R:F99	12.97	0	No	Yes	0	5	0	1
L:L:T30	R:R:D101	8.67	0	No	Yes	0	4	0	1
L:L:V32	R:R:W79	4.9	0	No	Yes	0	6	0	1
L:L:V32	R:R:T132	7.93	0	No	No	0	6	0	1
L:L:V32	R:R:N135	10.35	0	No	No	0	3	0	1
L:L:S34	R:R:H121	11.16	6	No	Yes	0	4	0	1
L:L:S34	R:R:E123	5.75	6	No	No	0	4	0	1
L:L:S34	R:R:N124	10.43	6	No	No	0	5	0	1
L:L:T36	R:R:W79	6.06	0	No	Yes	0	6	0	1
L:L:Y37	R:R:D77	16.09	1	Yes	Yes	0	9	0	1
L:L:Y37	R:R:G78	7.24	1	Yes	No	0	5	0	1
L:L:Y37	R:R:W79	11.58	1	Yes	Yes	0	6	0	1
L:L:?38	R:R:W79	2.82	1	Yes	Yes	0	6	0	1
L:L:?38	R:R:W128	8.46	1	Yes	No	0	5	0	1
L:L:?38	R:R:Y131	2.9	1	Yes	Yes	0	5	0	1
R:R:F99	R:R:Y41	3.09	1	Yes	No	5	3	1	1
R:R:P100	R:R:Y41	16.69	1	No	No	4	3	2	1
R:R:D97	R:R:K47	4.15	0	No	No	2	4	1	2
R:R:G78	R:R:W76	5.63	1	No	No	5	8	1	2
R:R:D77	R:R:G78	6.71	1	Yes	No	9	5	1	1
R:R:D77	R:R:W79	3.35	1	Yes	Yes	9	6	1	1
R:R:D77	R:R:Y131	8.05	1	Yes	Yes	9	5	1	1
R:R:W79	R:R:Y98	6.75	1	Yes	Yes	6	4	1	2
R:R:F99	R:R:W79	6.01	1	Yes	Yes	5	6	1	1
R:R:F102	R:R:W79	7.02	1	Yes	Yes	4	6	2	1
R:R:W79	R:R:Y131	18.33	1	Yes	Yes	6	5	1	1
R:R:L80	R:R:Y131	5.86	0	No	Yes	5	5	2	1
R:R:V108	R:R:W82	6.13	1	No	Yes	7	9	2	2
R:R:S129	R:R:W82	7.41	1	No	Yes	7	9	2	2
R:R:W82	R:R:Y131	6.75	1	Yes	Yes	9	5	2	1
R:R:F99	R:R:Y98	14.44	1	Yes	Yes	5	4	1	2
R:R:F99	R:R:P100	4.33	1	Yes	No	5	4	1	2
R:R:F102	R:R:F99	7.5	1	Yes	Yes	4	5	2	1
R:R:D101	R:R:F102	11.94	1	Yes	Yes	4	4	1	2
R:R:D101	R:R:N135	10.77	1	Yes	No	4	3	1	1
R:R:D101	R:R:T138	2.89	1	Yes	No	4	2	1	2
R:R:F102	R:R:N135	3.62	1	Yes	No	4	3	2	1
R:R:D103	R:R:K141	8.3	0	Yes	No	3	3	2	1
R:R:V108	R:R:Y131	12.62	1	No	Yes	7	5	2	1
R:R:H121	R:R:P122	7.63	6	Yes	No	4	5	1	2
R:R:E123	R:R:H121	8.62	6	No	Yes	4	4	1	1
R:R:H121	R:R:N124	6.38	6	Yes	No	4	5	1	1
R:R:H121	R:R:W128	17.98	6	Yes	No	4	5	1	1
R:R:N124	R:R:R126	4.82	6	No	No	5	4	1	2
R:R:N130	R:R:W128	7.91	0	No	No	8	5	2	1
R:R:S129	R:R:Y131	6.36	1	No	Yes	7	5	2	1
R:R:K141	R:R:K366	2.87	0	No	No	3	3	1	2
R:R:L142	R:R:Y146	8.21	5	Yes	Yes	2	2	1	1
R:R:D373	R:R:L148	4.07	0	No	Yes	5	5	2	1
R:R:H377	R:R:L148	15.43	4	No	Yes	7	5	1	1
R:R:Y149	R:R:Y150	7.94	0	Yes	No	5	4	1	2
R:R:L202	R:R:Y149	4.69	0	No	Yes	7	5	2	1
R:R:A152	R:R:H381	7.32	0	No	Yes	7	9	2	1
R:R:H156	R:R:I198	17.23	0	Yes	Yes	7	7	2	1
R:R:H156	R:R:H381	9.55	0	Yes	Yes	7	9	2	1
R:R:I198	R:R:N194	5.66	0	Yes	No	7	8	1	2
R:R:I198	R:R:L202	2.85	0	Yes	No	7	7	1	2
R:R:H226	R:R:I198	6.63	0	No	Yes	6	7	2	1
R:R:H201	R:R:V206	2.77	0	Yes	Yes	6	3	2	1
R:R:L202	R:R:V206	2.98	0	No	Yes	7	3	2	1
R:R:P207	R:R:V206	3.53	0	No	Yes	3	3	1	1
R:R:H223	R:R:Q227	14.84	0	No	No	5	7	2	1
R:R:H226	R:R:M230	3.94	0	No	No	6	6	2	1
R:R:I301	R:R:Q227	5.49	0	Yes	No	7	7	2	1
R:R:M230	R:R:Y234	4.79	0	No	Yes	6	7	1	1
R:R:M237	R:R:Y234	4.79	2	Yes	Yes	9	7	2	1
R:R:V305	R:R:Y234	8.83	2	No	Yes	7	7	1	1
R:R:F356	R:R:Y234	11.35	2	Yes	Yes	7	7	1	1
R:R:M237	R:R:Q383	5.44	2	Yes	Yes	9	9	2	2
R:R:L298	R:R:V293	2.98	3	Yes	No	6	6	2	1
R:R:H302	R:R:L298	5.14	0	Yes	Yes	6	6	1	2
R:R:F356	R:R:L309	3.65	2	Yes	No	7	7	1	2
R:R:G353	R:R:Q355	4.93	2	No	Yes	9	8	2	2
R:R:F356	R:R:G353	3.01	2	Yes	No	7	9	1	2
R:R:F356	R:R:Q355	11.71	2	Yes	Yes	7	8	1	2
R:R:Q355	R:R:Q383	7.68	2	Yes	Yes	8	9	2	2
R:R:F356	R:R:I380	6.28	2	Yes	Yes	7	6	1	1
R:R:F356	R:R:Q383	3.51	2	Yes	Yes	7	9	1	2
R:R:P363	R:R:R362	5.76	8	Yes	Yes	7	4	2	1
R:R:G369	R:R:R362	4.5	0	No	Yes	4	4	2	1
R:R:R362	R:R:Y372	4.12	8	Yes	No	4	7	1	2
R:R:D373	R:R:R362	9.53	0	No	Yes	5	4	2	1
R:R:P363	R:R:Y372	8.34	8	Yes	No	7	7	2	2
R:R:M376	R:R:Y372	8.38	0	No	No	7	7	2	2
R:R:I380	R:R:M376	2.92	0	Yes	No	6	7	1	2
R:R:H377	R:R:H381	9.55	4	No	Yes	7	9	1	1
R:R:H381	R:R:I380	3.98	0	Yes	Yes	9	6	1	1
R:R:H381	R:R:L151	2.57	0	Yes	No	9	5	1	2
L:L:L16	R:R:Y146	2.34	0	Yes	Yes	0	2	0	1
L:L:L23	R:R:Y146	2.34	0	No	Yes	0	2	0	1
R:R:L148	R:R:Y374	2.34	4	Yes	Yes	5	6	1	2
R:R:H296	R:R:Y299	2.18	0	No	No	2	7	2	1
R:R:G209	R:R:V212	1.84	0	No	No	3	3	1	2
L:L:A13	R:R:V206	1.7	0	No	Yes	0	3	0	1
L:L:A8	R:R:I380	1.62	0	No	Yes	0	6	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7TYL_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.73
Number of Linked Nodes	383
Number of Links	453
Number of Hubs	72
Number of Links mediated by Hubs	261
Number of Communities	15
Number of Nodes involved in Communities	93
Number of Links involved in Communities	124

Path Summary
Number Of Nodes in MetaPath	76
Number Of Links MetaPath	75
Number of Shortest Paths	120644
Length Of Smallest Path	3
Average Path Length	15.7488
Length of Longest Path	37
Minimum Path Strength	1.43
Average Path Strength	5.76797
Maximum Path Strength	21.34
Minimum Path Correlation	0.7
Average Path Correlation	0.956183
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.84615
Average % Of Corr. Nodes	59.7525
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	49.7715
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • molecular function activator activity • phosphorus-oxygen lyase activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • adenylate cyclase activator activity • adenylate cyclase activity • cation binding • metal ion binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • biological regulation • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of biological process • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • protein localization • regulation of localization • establishment of protein localization • nitrogen compound transport • localization • cellular macromolecule localization • regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • protein transport • regulation of cellular localization • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • synapse • cell junction • signaling receptor binding • molecular transducer activity • molecular function activator activity • signaling receptor activity • molecular function regulator activity • signaling receptor regulator activity • receptor ligand activity • signaling receptor activator activity • hormone activity • lipid binding • identical protein binding • positive regulation of cell communication • positive regulation of signal transduction • positive regulation of biological process • regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • regulation of intracellular signal transduction • intracellular signaling cassette • regulation of calcium-mediated signaling • positive regulation of calcium-mediated signaling • positive regulation of cellular process • regulation of signaling • positive regulation of intracellular signal transduction • regulation of response to stimulus • calcium-mediated signaling • regulation of cell communication • positive regulation of signaling • behavior • multicellular organismal process • eating behavior • feeding behavior • amylin receptor 1 signaling pathway • amylin receptor signaling pathway • calcitonin family receptor signaling pathway • myeloid leukocyte differentiation • regulation of leukocyte differentiation • cellular developmental process • regulation of developmental process • negative regulation of biological process • cell development • regulation of cell differentiation • regulation of cell development • regulation of osteoclast differentiation • multicellular organism development • cell differentiation • osteoclast differentiation • anatomical structure development • negative regulation of cellular process • regulation of immune system process • regulation of multicellular organismal process • negative regulation of cell differentiation • negative regulation of hemopoiesis • developmental process • regulation of multicellular organismal development • negative regulation of leukocyte differentiation • hemopoiesis • regulation of myeloid cell differentiation • negative regulation of developmental process • regulation of myeloid leukocyte differentiation • negative regulation of myeloid cell differentiation • negative regulation of osteoclast differentiation • negative regulation of myeloid leukocyte differentiation • negative regulation of cell development • myeloid cell differentiation • negative regulation of immune system process • immune system process • regulation of hemopoiesis • negative regulation of multicellular organismal process • leukocyte differentiation • monosaccharide metabolic process • carbohydrate metabolic process • hexose metabolic process • small molecule metabolic process • metabolic process • primary metabolic process • glucose metabolic process • negative regulation of tissue remodeling • homeostatic process • negative regulation of bone remodeling • regulation of bone remodeling • tissue homeostasis • regulation of tissue remodeling • regulation of bone resorption • bone resorption • negative regulation of bone resorption • multicellular organismal-level homeostasis • tissue remodeling • bone remodeling • anatomical structure homeostasis • amylin receptor 2 signaling pathway • system process • sensory perception • nervous system process • sensory perception of pain • positive regulation of cAMP/PKA signal transduction • cAMP/PKA signal transduction • regulation of cAMP/PKA signal transduction • amylin receptor 3 signaling pathway • intracellular vesicle • cytoplasmic vesicle • secretory granule • secretory vesicle • somatodendritic compartment • cell body • neuronal cell body • amide binding • amyloid-beta binding • peptide binding • calcitonin family receptor activity • peptide receptor activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • transmembrane signaling receptor activity • calcitonin receptor activity • amylin receptor activity • calcitonin gene-related peptide receptor activity • calcitonin binding • calcitonin family binding • peptide hormone binding • hormone binding • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • catabolic process • RNA metabolic process • macromolecule catabolic process • regulation of primary metabolic process • nucleobase-containing compound metabolic process • post-transcriptional regulation of gene expression • regulation of RNA metabolic process • regulation of mRNA catabolic process • regulation of nucleobase-containing compound metabolic process • RNA catabolic process • negative regulation of macromolecule metabolic process • regulation of biosynthetic process • mRNA catabolic process • negative regulation of metabolic process • regulation of macromolecule metabolic process • regulation of catabolic process • gene expression • mRNA metabolic process • macromolecule biosynthetic process • nucleic acid metabolic process • nucleobase-containing compound catabolic process • regulation of mRNA stability • regulation of gene expression • negative regulation of gene expression • biosynthetic process • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • regulation of RNA stability • nucleic acid catabolic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • regulation of mRNA metabolic process • regulation of metabolic process • positive regulation of ERK1 and ERK2 cascade • positive regulation of MAPK cascade • regulation of MAPK cascade • MAPK cascade • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of macromolecule biosynthetic process • positive regulation of metabolic process • positive regulation of gene expression • positive regulation of biosynthetic process • positive regulation of macromolecule metabolic process • regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • phosphatidylinositol 3-kinase/protein kinase B signal transduction • response to corticosteroid • response to steroid hormone • response to glucocorticoid • response to amyloid-beta • cell surface receptor signaling pathway • calcitonin gene-related peptide receptor signaling pathway • ossification • regulation of ossification • negative regulation of ossification • cell projection • cilium • plasma membrane bounded cell projection • amylin receptor complex • amylin receptor complex 3 • receptor complex • plasma membrane signaling receptor complex • G protein-coupled receptor complex • calcitonin family receptor complex • amylin receptor complex 2 • amylin receptor complex 1 • axon • neuron projection • acrosomal vesicle • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception of taste • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	NH2
PDB Residues	L:L:?38
Environment Details	Open EMBL-EBI Page
Code	NH2
Name	AMINO GROUP
Synonyms
Identifier
Formula	H2 N
Molecular Weight	16.023
SMILES
PubChem	123329
Formal Charge	0
Total Atoms	3
Total Chiral Atoms	0
Total Bonds	2
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P30988
Sequence	>7TYL_nogp_Chain_R Y V V G R K K M M D A Q Y K C Y D R M Q Q L P A Y Q G E G P Y C N R T W D G W L C W D D T P A G V L S Y Q F C P D Y F P D F D P S E K V T K Y C D E K G V W F K H P E N N R T W S N Y T M C N A F T P E K L K N A Y V L Y Y L A I V G H S L S I F T L V I S L G I F V F F R S L G C Q R V T L H K N M F L T Y I L N S M I I I I H L V E V V P N G E L V R R D P V S C K I L H F F H Q Y M M A C N Y F W M L C E G I Y L H T L I V V A V F T E K Q R L R W Y Y L L G W G F P L V P T T I H A I T R A V Y F N D N C W L S V E T H L L Y I I H G P V M A A L V V N F F F L L N I V R V L V T K M R E T H E A E S H M Y L K A V K A T M I L V P L L G I Q F V V F P W R P S N K M L G K I Y D Y V M H S L I H F Q G F F V A T I Y C F C N N E V Q T T V K R Q W A Q F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9AUC	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Calcitonin gene-related peptide-1	-	Gs/β1/γ2; RAMP1	2.4	2024-04-24	10.1021/acs.biochem.4c00114
	9AUC (No Gprot)	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Calcitonin gene-related peptide-1	-		2.4	2024-04-24	10.1021/acs.biochem.4c00114
	8F0J	B1	Peptide	Calcitonin	CT	Homo sapiens	Pramlintide Analogue San45	-	Gs/β1/γ2	2	2023-08-02	10.1038/s41589-023-01393-4
	8F0J (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	Pramlintide Analogue San45	-		2	2023-08-02	10.1038/s41589-023-01393-4
	8F2B	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Pramlintide Analogue San45	-	Gs/β1/γ2; RAMP3	2	2023-08-02	10.1038/s41589-023-01393-4
	8F2B (No Gprot)	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Pramlintide Analogue San45	-		2	2023-08-02	10.1038/s41589-023-01393-4
	8F2A	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Pramlintide Analogue San385	-	Gs/β1/γ2; RAMP3	2.2	2023-08-02	10.1038/s41589-023-01393-4
	8F2A (No Gprot)	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Pramlintide Analogue San385	-		2.2	2023-08-02	10.1038/s41589-023-01393-4
	8F0K	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Pramlintide Analogue San385	-	Gs/β1/γ2; RAMP3	1.9	2023-08-02	10.1038/s41589-023-01393-4
	8F0K (No Gprot)	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Pramlintide Analogue San385	-		1.9	2023-08-02	10.1038/s41589-023-01393-4
	7X5H	A	Amine	5-Hydroxytryptamine	5-HT_5A	Homo sapiens	5-CT	-	Gi1/β1/γ2	3.1	2022-09-14	10.1038/s41421-022-00412-3
	7X5H (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_5A	Homo sapiens	5-CT	-		3.1	2022-09-14	10.1038/s41421-022-00412-3
	7XTC	A	Amine	5-Hydroxytryptamine	5-HT₇	Homo sapiens	5-CT	-	Gs/β1/γ2	3.2	2022-07-27	10.1016/j.molcel.2022.05.031
	7XTC (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT₇	Homo sapiens	5-CT	-		3.2	2022-07-27	10.1016/j.molcel.2022.05.031
	7UM5	A	Amine	5-Hydroxytryptamine	5-HT_5A	Homo sapiens	5-CT	-	chim(NtGi1-Go)/β1/γ2	2.73	2022-07-20	10.1038/s41594-022-00796-6
	7UM5 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_5A	Homo sapiens	5-CT	-		2.73	2022-07-20	10.1038/s41594-022-00796-6
	7TYN	B1	Peptide	Calcitonin	CT	Homo sapiens	Calcitonin-1	-	Gs/β1/γ2	2.6	2022-03-30	10.1126/science.abm9609
	7TYN (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	Calcitonin-1	-		2.6	2022-03-30	10.1126/science.abm9609
	7TYI	B1	Peptide	Calcitonin	CT	Homo sapiens	Amylin	-	Gs/β1/γ2	3.3	2022-03-30	10.1126/science.abm9609
	7TYI (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	Amylin	-		3.3	2022-03-30	10.1126/science.abm9609
	7TYX	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Amylin	-	Gs/β1/γ2; RAMP2	2.55	2022-03-30	10.1126/science.abm9609
	7TYX (No Gprot)	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Amylin	-		2.55	2022-03-30	10.1126/science.abm9609
	7TYO	B1	Peptide	Calcitonin	CT	Homo sapiens	Calcitonin	-	Gs/β1/γ2	2.7	2022-03-23	10.1126/science.abm9609
	7TYO (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	Calcitonin	-		2.7	2022-03-23	10.1126/science.abm9609
	7TYL	B1	Peptide	Calcitonin	CT	Homo sapiens	Amylin	-	Gs/β1/γ2	3.3	2022-03-23	10.1126/science.abm9609
	7TYL (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	Amylin	-		3.3	2022-03-23	10.1126/science.abm9609
	7TYW	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Calcitonin-1	-	Gs/β1/γ2; RAMP1	3	2022-03-23	10.1126/science.abm9609
	7TYW (No Gprot)	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Calcitonin-1	-		3	2022-03-23	10.1126/science.abm9609
	7TYF	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Amylin	-	Gs/β1/γ2; RAMP1	2.2	2022-03-23	10.1126/science.abm9609
	7TYF (No Gprot)	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Amylin	-		2.2	2022-03-23	10.1126/science.abm9609
	7TYY	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Calcitonin-1	-	Gs/β1/γ2; RAMP2	3	2022-03-23	10.1126/science.abm9609
	7TYY (No Gprot)	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Calcitonin-1	-		3	2022-03-23	10.1126/science.abm9609
	7TYH	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Calcitonin-1	-	Gs/β1/γ2; RAMP2	3.3	2022-03-23	10.1126/science.abm9609
	7TYH (No Gprot)	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Calcitonin-1	-		3.3	2022-03-23	10.1126/science.abm9609
	7TZF	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Amylin	-	Gs/β1/γ2; RAMP3	2.4	2022-03-23	10.1126/science.abm9609
	7TZF (No Gprot)	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Amylin	-		2.4	2022-03-23	10.1126/science.abm9609
	7KNU	B1	Peptide	Calcitonin	CT Like	Homo sapiens	Calcitonin gene-related peptide-1	-	RAMP1	3.49	2021-02-24	10.1126/science.abf7258
	7KNT	B1	Peptide	Calcitonin	CT Like	Homo sapiens	-	-	RAMP1	3.15	2021-02-24	10.1126/science.abf7258
	6PH7	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	Nerol	Gt(CT)	2.9	2020-07-01	To be published
	6PGS	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	Geraniol	Gt(CT)	2.9	2020-07-01	To be published
	6PEL	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	Citronellol	Gt(CT)	3.19	2020-06-24	To be published
	6UVA	B1	Peptide	Calcitonin	CT Like (AM2)	Homo sapiens	Adrenomedullin-2	-	Gs/β1/γ2; RAMP3	2.3	2020-04-01	10.1021/acsptsci.9b00080
	6UVA (No Gprot)	B1	Peptide	Calcitonin	CT Like (AM2)	Homo sapiens	Adrenomedullin-2	-		2.3	2020-04-01	10.1021/acsptsci.9b00080
	6UUS	B1	Peptide	Calcitonin	CT Like (AM2)	Homo sapiens	Adrenomedullin	-	Gs/β1/γ2; RAMP3	2.4	2020-04-01	10.1021/acsptsci.9b00080
	6UUS (No Gprot)	B1	Peptide	Calcitonin	CT Like (AM2)	Homo sapiens	Adrenomedullin	-		2.4	2020-04-01	10.1021/acsptsci.9b00080
	6UUN	B1	Peptide	Calcitonin	CT Like (AM1)	Homo sapiens	Adrenomedullin	-	Gs/β1/γ2; RAMP2	3	2020-03-25	10.1021/acsptsci.9b00080
	6UUN (No Gprot)	B1	Peptide	Calcitonin	CT Like (AM1)	Homo sapiens	Adrenomedullin	-		3	2020-03-25	10.1021/acsptsci.9b00080
	6NWE	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl-β-D-Glucopyranoside	-	Gt(CT)	2.71	2020-02-12	To be published
	6TP4	A	Peptide	Orexin	OX₁	Homo sapiens	ACT-462206	-	-	3.01	2020-01-01	10.1021/acs.jmedchem.9b01787
	6NIY	B1	Peptide	Calcitonin	CT	Homo sapiens	Adrenomedullin	-	Gs/β1/γ2	3.34	2019-01-23	10.1021/acsptsci.8b00056
	6NIY (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	Adrenomedullin	-		3.34	2019-01-23	10.1021/acsptsci.8b00056
	6E3Y	B1	Peptide	Calcitonin	CT Like	Homo sapiens	Calcitonin gene-related peptide-1	-	Gs/β1/γ2; RAMP1	3.3	2018-09-19	10.1038/s41586-018-0535-y
	6E3Y (No Gprot)	B1	Peptide	Calcitonin	CT Like	Homo sapiens	Calcitonin gene-related peptide-1	-		3.3	2018-09-19	10.1038/s41586-018-0535-y
	5WKT	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl-β-D-Glucopyranoside	-	Gt(CT)	3.2	2017-12-13	10.1038/nprot.2017.135
	5UZ7	B1	Peptide	Calcitonin	CT	Homo sapiens	-	-	Gs/β1/γ2	4.1	2017-05-03	10.1038/nature22327
	5UZ7 (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	-	-		4.1	2017-05-03	10.1038/nature22327
	5EN0	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gt(CT)	2.81	2016-08-10	10.15252/embr.201642671
	4X1H	A	Sensory	Opsins	Rhodopsin	Bos taurus	Nonyl-β-D-Glucopyranoside	-	Gt(CT)	2.29	2015-11-04	10.1016/j.str.2015.09.015
	4J4Q	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl β-D-Glucopyranoside	-	Gt(CT)	2.65	2013-10-30	10.1002/anie.201302374
	4BEY	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	Gt(CT)	2.9	2013-05-08	10.1038/embor.2013.44
	4A4M	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gt(CT)	3.3	2012-01-25	10.1073/pnas.1114089108
	2X72	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gt(CT)	3	2011-03-16	10.1038/nature09795
	3PQR	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gt(CT)	2.85	2011-03-09	10.1038/nature09789
	3DQB	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	Gt(CT)	3.2	2008-09-23	10.1038/nature07330

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7TYL_nogp.zip

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You can also read or download a guide explaining the meaning of all files and numerical data.