psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:K1	R:R:E294	5.4	No	No	0	0	3
2	L:L:C2	L:L:C7	7.28	No	Yes	3	0	0
3	L:L:C2	R:R:V293	3.42	No	Yes	3	0	6
4	L:L:C2	R:R:L298	3.17	No	No	0	0	6
5	L:L:T4	L:L:T6	3.14	No	Yes	0	0	0
6	L:L:A5	R:R:M376	3.22	No	Yes	0	0	7
7	L:L:T6	R:R:Y234	3.75	Yes	Yes	0	0	7
8	L:L:T6	R:R:H302	9.58	Yes	Yes	0	0	6
9	L:L:C7	L:L:Q10	4.58	Yes	No	0	0	0
10	L:L:C7	R:R:V293	3.42	Yes	Yes	3	0	6
11	L:L:C7	R:R:H302	5.9	Yes	Yes	3	0	6
12	L:L:T9	R:R:I198	3.04	No	Yes	0	0	7
13	L:L:T9	R:R:H381	6.85	No	Yes	0	0	9
14	L:L:Q10	R:R:H226	6.18	No	No	0	0	6
15	L:L:Q10	R:R:Q227	8.96	No	Yes	0	0	7
16	L:L:L12	R:R:L148	4.15	No	Yes	4	0	5
17	L:L:L12	R:R:H377	5.14	No	No	4	0	7
18	L:L:N14	L:L:R18	8.44	No	No	0	0	0
19	L:L:N14	R:R:V293	7.39	No	Yes	0	0	6
20	L:L:F15	L:L:S19	5.28	No	Yes	8	0	0
21	L:L:F15	R:R:F137	7.5	No	Yes	8	0	1
22	L:L:L16	R:R:A145	3.15	No	No	0	0	4
23	L:L:V17	R:R:V206	4.81	No	No	0	0	3
24	L:L:V17	R:R:V212	3.21	No	No	0	0	3
25	L:L:R18	R:R:F137	9.62	No	Yes	0	0	1
26	L:L:S19	L:L:S20	4.89	Yes	No	0	0	0
27	L:L:S19	R:R:F137	6.61	Yes	Yes	8	0	1
28	L:L:S19	R:R:L142	4.5	Yes	No	0	0	2
29	L:L:S20	R:R:Y146	5.09	No	No	0	0	2
30	L:L:N21	R:R:G209	6.79	No	No	0	0	3
31	L:L:L27	L:L:N22	9.61	No	No	0	0	0
32	L:L:L23	R:R:V212	4.47	No	No	0	0	3
33	L:L:L23	R:R:N288	4.12	No	No	0	0	4
34	L:L:G24	L:L:P25	4.06	No	No	0	0	0
35	L:L:P28	L:L:V26	7.07	No	No	0	0	0
36	L:L:L27	R:R:R213	8.5	No	No	0	0	2
37	L:L:T30	R:R:F99	11.67	No	Yes	1	0	5
38	L:L:T30	R:R:D101	10.12	No	Yes	1	0	4
39	L:L:T30	R:R:F102	6.49	No	Yes	1	0	4
40	L:L:N31	L:L:N35	4.09	No	No	0	0	0
41	L:L:V32	R:R:W128	3.68	No	Yes	0	0	5
42	L:L:V32	R:R:Y131	3.79	No	Yes	0	0	5
43	L:L:V32	R:R:T132	3.17	No	No	0	0	6
44	L:L:S34	R:R:H121	12.55	No	Yes	0	0	4
45	L:L:S34	R:R:N124	8.94	No	No	0	0	5
46	L:L:T36	L:L:Y37	4.99	No	Yes	1	0	0
47	L:L:?38	L:L:T36	7.3	No	No	1	0	0
48	L:L:?38	L:L:Y37	8.7	No	Yes	1	0	0
49	L:L:Y37	R:R:G78	8.69	Yes	No	0	0	5
50	L:L:Y37	R:R:W79	12.54	Yes	Yes	1	0	6
51	L:L:?38	R:R:W79	11.28	No	Yes	1	0	6
52	R:R:L40	R:R:P100	3.28	No	No	0	5	4
53	R:R:D287	R:R:L40	6.79	No	No	0	3	5
54	R:R:R45	R:R:Y41	4.12	No	No	0	7	3
55	R:R:K47	R:R:Y98	5.97	No	Yes	0	4	4
56	R:R:M48	R:R:Y98	4.79	No	Yes	0	6	4
57	R:R:Q52	R:R:Y56	12.4	Yes	No	0	6	3
58	R:R:Q52	R:R:W76	12.05	Yes	No	0	6	8
59	R:R:C55	R:R:R74	4.18	No	Yes	9	9	4
60	R:R:C55	R:R:C81	7.28	No	No	9	9	9
61	R:R:M59	R:R:Y56	5.99	No	No	0	5	3
62	R:R:Q61	R:R:R58	15.19	No	No	0	3	3
63	R:R:M59	R:R:Q60	8.16	No	No	0	5	3
64	R:R:M59	R:R:R74	3.72	No	Yes	0	5	4
65	R:R:Q60	R:R:Q61	3.84	No	No	0	3	3
66	R:R:L62	R:R:P63	3.28	No	No	0	3	1
67	R:R:D84	R:R:L62	10.86	No	No	0	4	3
68	R:R:P86	R:R:Y71	5.56	No	No	0	2	3
69	R:R:C112	R:R:C72	7.28	No	No	1	9	9
70	R:R:C72	R:R:D113	4.67	No	No	0	9	5
71	R:R:C72	R:R:W118	11.75	No	Yes	1	9	9
72	R:R:C81	R:R:R74	5.57	No	Yes	9	9	4
73	R:R:D84	R:R:R74	5.96	No	Yes	0	4	4
74	R:R:T75	R:R:W118	6.06	No	Yes	0	5	9
75	R:R:C81	R:R:W76	6.53	No	No	0	9	8
76	R:R:D77	R:R:G78	3.35	Yes	No	0	9	5
77	R:R:D77	R:R:L80	5.43	Yes	No	1	9	5
78	R:R:D77	R:R:W82	8.93	Yes	Yes	1	9	9
79	R:R:D77	R:R:S129	4.42	Yes	Yes	1	9	7
80	R:R:D77	R:R:Y131	5.75	Yes	Yes	1	9	5
81	R:R:F99	R:R:W79	9.02	Yes	Yes	1	5	6
82	R:R:F102	R:R:W79	5.01	Yes	Yes	1	4	6
83	R:R:W79	R:R:Y131	11.58	Yes	Yes	1	6	5
84	R:R:L80	R:R:Q93	13.31	No	No	0	5	6
85	R:R:L80	R:R:Y131	3.52	No	Yes	1	5	5
86	R:R:Q93	R:R:W82	7.67	No	Yes	0	6	9
87	R:R:V108	R:R:W82	4.9	No	Yes	0	7	9
88	R:R:K110	R:R:W82	22.05	No	Yes	1	8	9
89	R:R:W118	R:R:W82	4.69	Yes	Yes	1	9	9
90	R:R:S129	R:R:W82	6.18	Yes	Yes	1	7	9
91	R:R:P86	R:R:T85	3.5	No	Yes	0	2	7
92	R:R:C112	R:R:T85	3.38	No	Yes	0	9	7
93	R:R:L90	R:R:V89	4.47	No	No	0	4	5
94	R:R:V89	R:R:Y111	7.57	No	No	0	5	4
95	R:R:L90	R:R:Y92	7.03	No	No	10	4	4
96	R:R:L90	R:R:T109	5.9	No	No	10	4	5
97	R:R:K107	R:R:Y92	3.58	No	No	0	3	4
98	R:R:T109	R:R:Y92	6.24	No	No	10	5	4
99	R:R:F94	R:R:K107	6.2	No	No	0	3	3
100	R:R:C95	R:R:V108	3.42	No	No	0	9	7
101	R:R:C134	R:R:C95	7.28	No	No	0	9	9
102	R:R:P96	R:R:Y98	6.95	No	Yes	0	9	4
103	R:R:P96	R:R:Y131	6.95	No	Yes	0	9	5
104	R:R:D101	R:R:F99	3.58	Yes	Yes	1	4	5
105	R:R:F102	R:R:F99	4.29	Yes	Yes	1	4	5
106	R:R:D101	R:R:F102	9.55	Yes	Yes	1	4	4
107	R:R:D101	R:R:N135	5.39	Yes	No	0	4	3
108	R:R:F102	R:R:Y131	7.22	Yes	Yes	1	4	5
109	R:R:D103	R:R:E106	6.5	Yes	Yes	11	3	4
110	R:R:A136	R:R:D103	4.63	No	Yes	0	2	3
111	R:R:D103	R:R:K141	4.15	Yes	No	11	3	3
112	R:R:C134	R:R:E106	3.04	No	Yes	0	9	4
113	R:R:E106	R:R:K141	4.05	Yes	No	11	4	3
114	R:R:E106	R:R:K366	9.45	Yes	No	0	4	3
115	R:R:V108	R:R:Y131	10.09	No	Yes	0	7	5
116	R:R:K110	R:R:W118	8.12	No	Yes	1	8	9
117	R:R:K110	R:R:S129	9.18	No	Yes	1	8	7
118	R:R:E114	R:R:Y111	26.93	No	No	0	2	4
119	R:R:F119	R:R:Y111	4.13	No	No	0	4	4
120	R:R:C112	R:R:W118	9.14	No	Yes	1	9	9
121	R:R:D113	R:R:G116	6.71	No	No	0	5	9
122	R:R:K120	R:R:R126	4.95	No	No	0	1	4
123	R:R:H121	R:R:P122	10.68	Yes	No	0	4	5
124	R:R:E123	R:R:H121	11.08	No	Yes	0	4	4
125	R:R:H121	R:R:W128	7.41	Yes	Yes	0	4	5
126	R:R:N124	R:R:R126	8.44	No	No	0	5	4
127	R:R:N130	R:R:W128	5.65	No	Yes	0	8	5
128	R:R:S129	R:R:Y131	3.82	Yes	Yes	1	7	5
129	R:R:N130	R:R:T132	5.85	No	No	0	8	6
130	R:R:A136	R:R:F137	4.16	No	Yes	0	2	1
131	R:R:P139	R:R:T138	5.25	No	No	0	3	2
132	R:R:K141	R:R:T138	9.01	No	No	0	3	2
133	R:R:L142	R:R:Y146	10.55	No	No	0	2	2
134	R:R:K370	R:R:N144	13.99	No	No	4	4	4
135	R:R:N144	R:R:Y374	8.14	No	Yes	4	4	6
136	R:R:V147	R:R:Y374	8.83	No	Yes	0	4	6
137	R:R:D373	R:R:L148	5.43	No	Yes	0	5	5
138	R:R:L148	R:R:Y374	3.52	Yes	Yes	4	5	6
139	R:R:H377	R:R:L148	11.57	No	Yes	4	7	5
140	R:R:I153	R:R:Y149	8.46	No	No	0	7	5
141	R:R:L202	R:R:Y149	5.86	No	No	0	7	5
142	R:R:F382	R:R:L151	3.65	Yes	No	0	7	5
143	R:R:A152	R:R:H381	7.32	No	Yes	0	7	9
144	R:R:F382	R:R:G155	9.03	Yes	No	0	7	8
145	R:R:H156	R:R:S195	11.16	Yes	No	0	7	7
146	R:R:H156	R:R:I198	17.23	Yes	Yes	0	7	7
147	R:R:H156	R:R:H381	9.55	Yes	Yes	0	7	9
148	R:R:F385	R:R:L158	3.65	Yes	No	0	5	4
149	R:R:S159	R:R:S195	4.89	No	No	0	9	7
150	R:R:G384	R:R:S159	3.71	No	No	0	9	9
151	R:R:I160	R:R:S195	3.1	No	No	0	5	7
152	R:R:F161	R:R:I165	5.02	No	No	0	4	5
153	R:R:F385	R:R:T162	6.49	Yes	No	0	5	6
154	R:R:F188	R:R:L163	6.09	No	No	0	8	8
155	R:R:I192	R:R:L163	4.28	Yes	No	0	7	8
156	R:R:A388	R:R:L163	3.15	No	No	0	8	8
157	R:R:A388	R:R:S166	3.42	No	No	0	8	9
158	R:R:C392	R:R:S166	6.89	No	No	0	9	9
159	R:R:F393	R:R:S166	5.28	No	No	0	8	9
160	R:R:F173	R:R:I169	3.77	Yes	No	0	7	8
161	R:R:F170	R:R:V181	5.24	Yes	No	0	8	9
162	R:R:F170	R:R:K185	4.96	Yes	No	0	8	6
163	R:R:F170	R:R:F188	6.43	Yes	No	0	8	8
164	R:R:C392	R:R:F170	5.59	No	Yes	0	9	8
165	R:R:K185	R:R:V171	3.04	No	No	0	6	4
166	R:R:F172	R:R:F173	6.43	No	Yes	0	2	7
167	R:R:F173	R:R:T401	3.89	Yes	Yes	0	7	7
168	R:R:F173	R:R:V402	3.93	Yes	No	0	7	5
169	R:R:F173	R:R:Q405	7.03	Yes	No	0	7	4
170	R:R:S175	R:R:T401	3.2	No	Yes	0	8	7
171	R:R:L176	R:R:T401	4.42	No	Yes	0	9	7
172	R:R:C178	R:R:V181	3.42	No	No	0	8	9
173	R:R:Q179	R:R:Y243	13.53	No	Yes	6	7	8
174	R:R:Q179	R:R:Q257	7.68	No	Yes	6	7	5
175	R:R:L259	R:R:Q179	9.32	No	No	0	5	7
176	R:R:R180	R:R:Y243	4.12	No	Yes	0	9	8
177	R:R:N395	R:R:R180	3.62	No	No	0	9	9
178	R:R:L183	R:R:W236	4.56	No	Yes	0	8	9
179	R:R:L183	R:R:Y243	7.03	No	Yes	0	8	8
180	R:R:E240	R:R:H184	12.31	No	No	0	9	9
181	R:R:H184	R:R:Y391	7.62	No	Yes	0	9	8
182	R:R:N186	R:R:W236	9.04	No	Yes	0	9	9
183	R:R:N186	R:R:Y263	5.81	No	No	0	9	5
184	R:R:M187	R:R:Y191	7.18	No	Yes	0	8	8
185	R:R:E240	R:R:M187	4.06	No	No	0	9	8
186	R:R:F188	R:R:V387	3.93	No	No	0	8	9
187	R:R:L189	R:R:W267	3.42	No	Yes	0	3	9
188	R:R:C232	R:R:T190	5.07	No	Yes	2	8	9
189	R:R:N233	R:R:T190	4.39	Yes	Yes	2	9	9
190	R:R:T190	R:R:W236	3.64	Yes	Yes	2	9	9
191	R:R:T190	R:R:W267	6.06	Yes	Yes	2	9	9
192	R:R:N233	R:R:Y191	16.28	Yes	Yes	2	9	8
193	R:R:M237	R:R:Y191	3.59	Yes	Yes	2	9	8
194	R:R:Q383	R:R:Y191	11.27	Yes	Yes	2	9	8
195	R:R:G384	R:R:Y191	4.35	No	Yes	0	9	8
196	R:R:V387	R:R:Y191	3.79	No	Yes	0	9	8
197	R:R:L193	R:R:M229	7.07	No	No	0	6	4
198	R:R:I198	R:R:N194	5.66	Yes	No	0	7	8
199	R:R:N194	R:R:N233	4.09	No	Yes	0	8	9
200	R:R:H226	R:R:I197	3.98	No	No	0	6	5
201	R:R:H226	R:R:I198	3.98	No	Yes	0	6	7
202	R:R:E204	R:R:I200	8.2	No	No	0	4	6
203	R:R:H201	R:R:V205	9.69	Yes	No	0	6	7
204	R:R:H201	R:R:H223	3.58	Yes	No	0	6	5
205	R:R:H201	R:R:L291	6.43	Yes	No	0	6	6
206	R:R:P207	R:R:V206	3.53	No	No	0	3	3
207	R:R:L211	R:R:N208	4.12	No	No	0	1	3
208	R:R:L211	R:R:P216	3.28	No	Yes	12	1	4
209	R:R:C219	R:R:L211	3.17	No	No	12	9	1
210	R:R:P216	R:R:R214	10.09	Yes	No	0	4	4
211	R:R:D215	R:R:N288	12.12	No	No	0	6	4
212	R:R:P216	R:R:S218	3.56	Yes	No	0	4	3
213	R:R:C219	R:R:P216	3.77	No	Yes	12	9	4
214	R:R:C219	R:R:C289	7.28	No	No	0	9	9
215	R:R:K220	R:R:N286	6.99	No	No	5	7	7
216	R:R:K220	R:R:W290	5.8	No	Yes	5	7	9
217	R:R:H223	R:R:Q227	8.65	No	Yes	0	5	7
218	R:R:H223	R:R:W290	5.29	No	Yes	0	5	9
219	R:R:F224	R:R:T274	6.49	No	No	0	5	6
220	R:R:M230	R:R:Q227	5.44	No	Yes	3	6	7
221	R:R:H302	R:R:Q227	4.95	Yes	Yes	3	6	7
222	R:R:L271	R:R:Y228	5.86	No	No	0	4	8
223	R:R:T274	R:R:Y228	3.75	No	No	0	6	8
224	R:R:M230	R:R:Y234	5.99	No	Yes	0	6	7
225	R:R:H302	R:R:M230	5.25	Yes	No	3	6	6
226	R:R:C232	R:R:W267	5.22	No	Yes	2	8	9
227	R:R:M237	R:R:N233	4.21	Yes	Yes	2	9	9
228	R:R:M237	R:R:Y234	4.79	Yes	Yes	0	9	7
229	R:R:V305	R:R:Y234	5.05	No	Yes	0	7	7
230	R:R:F356	R:R:Y234	13.41	Yes	Yes	0	7	7
231	R:R:F235	R:R:L265	3.65	Yes	No	7	5	7
232	R:R:F235	R:R:F269	8.57	Yes	No	7	5	3
233	R:R:F235	R:R:P270	4.33	Yes	Yes	7	5	9
234	R:R:A308	R:R:F235	4.16	No	Yes	0	7	5
235	R:R:C239	R:R:W236	5.22	No	Yes	0	7	9
236	R:R:G266	R:R:W236	8.44	No	Yes	0	9	9
237	R:R:W236	R:R:W267	14.06	Yes	Yes	2	9	9
238	R:R:M237	R:R:Q383	5.44	Yes	Yes	2	9	9
239	R:R:I242	R:R:L238	7.14	No	No	0	7	8
240	R:R:A308	R:R:L238	3.15	No	No	0	7	8
241	R:R:C239	R:R:L265	4.76	No	No	0	7	7
242	R:R:E240	R:R:L351	7.95	No	No	0	9	9
243	R:R:G241	R:R:N312	3.39	No	No	0	8	9
244	R:R:I242	R:R:Y262	4.84	No	Yes	0	7	7
245	R:R:L247	R:R:Y243	3.52	No	Yes	6	8	8
246	R:R:Q257	R:R:Y243	7.89	Yes	Yes	6	5	8
247	R:R:Y243	R:R:Y262	7.94	Yes	Yes	6	8	7
248	R:R:I319	R:R:L244	4.28	No	No	0	9	9
249	R:R:H245	R:R:V249	15.22	Yes	No	13	8	6
250	R:R:F315	R:R:H245	18.1	No	Yes	0	8	8
251	R:R:H245	R:R:N318	10.2	Yes	No	13	8	8
252	R:R:H245	R:R:I319	3.98	Yes	No	0	8	9
253	R:R:Q257	R:R:T246	9.92	Yes	No	0	5	7
254	R:R:L247	R:R:Q257	3.99	No	Yes	6	8	5
255	R:R:N318	R:R:V249	7.39	No	No	13	8	6
256	R:R:A251	R:R:T254	3.36	No	No	0	6	6
257	R:R:Q257	R:R:Y262	3.38	Yes	Yes	6	5	7
258	R:R:R258	R:R:W261	13	No	No	0	5	2
259	R:R:L259	R:R:Y262	4.69	No	Yes	0	5	7
260	R:R:L259	R:R:Y263	3.52	No	No	0	5	5
261	R:R:F269	R:R:L265	4.87	No	No	7	3	7
262	R:R:F269	R:R:P270	4.33	No	Yes	7	3	9
263	R:R:P273	R:R:V272	5.3	No	No	0	6	4
264	R:R:I301	R:R:T274	4.56	No	No	0	7	6
265	R:R:H277	R:R:R281	13.54	Yes	Yes	0	7	7
266	R:R:H277	R:R:L298	5.14	Yes	No	0	7	6
267	R:R:H277	R:R:I301	9.28	Yes	No	0	7	7
268	R:R:T280	R:R:Y284	3.75	No	No	0	4	2
269	R:R:F285	R:R:R281	7.48	No	Yes	5	6	7
270	R:R:R281	R:R:W290	12	Yes	Yes	5	7	9
271	R:R:R281	R:R:T295	3.88	Yes	No	5	7	4
272	R:R:V283	R:R:Y284	10.09	No	No	0	3	2
273	R:R:F285	R:R:S292	5.28	No	No	0	6	4
274	R:R:F285	R:R:T295	18.16	No	No	5	6	4
275	R:R:N286	R:R:W290	3.39	No	Yes	5	7	9
276	R:R:D287	R:R:S292	7.36	No	No	0	3	4
277	R:R:C289	R:R:L291	3.17	No	No	0	9	6
278	R:R:L297	R:R:T295	5.9	No	No	0	4	4
279	R:R:H296	R:R:Y299	3.27	No	No	0	2	7
280	R:R:G303	R:R:P304	4.06	No	No	0	4	9
281	R:R:F356	R:R:L309	3.65	Yes	No	0	7	7
282	R:R:F314	R:R:V310	3.93	No	No	0	5	4
283	R:R:L352	R:R:N312	13.73	No	No	0	9	9
284	R:R:F313	R:R:L317	9.74	Yes	No	0	6	5
285	R:R:F313	R:R:I354	5.02	Yes	Yes	0	6	6
286	R:R:F313	R:R:V357	6.55	Yes	No	0	6	7
287	R:R:I354	R:R:L316	5.71	Yes	No	0	6	9
288	R:R:N318	R:R:R321	8.44	No	No	0	8	8
289	R:R:T345	R:R:V320	3.17	No	No	0	9	7
290	R:R:R321	R:R:V322	3.92	No	No	0	8	8
291	R:R:R328	R:R:V324	6.54	No	Yes	0	6	5
292	R:R:K340	R:R:M327	5.76	No	No	0	8	7
293	R:R:E332	R:R:H336	13.54	No	No	0	5	6
294	R:R:E334	R:R:M337	5.41	No	No	0	6	7
295	R:R:E334	R:R:Y338	14.59	No	No	0	6	7
296	R:R:H336	R:R:K340	6.55	No	No	0	6	8
297	R:R:I347	R:R:I390	5.89	No	No	0	8	8
298	R:R:P350	R:R:V349	3.53	No	No	0	9	8
299	R:R:I354	R:R:V349	10.75	Yes	No	0	6	8
300	R:R:L351	R:R:Y391	12.89	No	Yes	0	9	8
301	R:R:I354	R:R:L352	4.28	Yes	No	0	6	9
302	R:R:G353	R:R:Q355	4.93	No	Yes	0	9	8
303	R:R:F356	R:R:Q355	11.71	Yes	Yes	2	7	8
304	R:R:L379	R:R:Q355	3.99	No	Yes	0	5	8
305	R:R:Q355	R:R:Q383	7.68	Yes	Yes	2	8	9
306	R:R:F356	R:R:I380	6.28	Yes	No	0	7	6
307	R:R:F356	R:R:Q383	3.51	Yes	Yes	2	7	9
308	R:R:F359	R:R:V358	9.18	No	No	0	6	5
309	R:R:F359	R:R:W361	4.01	No	No	0	6	4
310	R:R:F359	R:R:M376	3.73	No	Yes	0	6	7
311	R:R:P360	R:R:W361	5.4	No	No	0	5	4
312	R:R:P363	R:R:W361	5.4	Yes	No	0	7	4
313	R:R:R362	R:R:Y372	4.12	No	No	0	4	7
314	R:R:D373	R:R:R362	9.53	No	No	0	5	4
315	R:R:L368	R:R:P363	4.93	No	Yes	0	3	7
316	R:R:P363	R:R:Y372	6.95	Yes	No	0	7	7
317	R:R:L368	R:R:N365	12.36	No	No	0	3	4
318	R:R:K370	R:R:Y374	7.17	No	Yes	4	4	6
319	R:R:M376	R:R:Y372	10.78	Yes	No	0	7	7
320	R:R:I380	R:R:M376	5.83	No	Yes	0	6	7
321	R:R:H377	R:R:H381	9.55	No	Yes	0	7	9
322	R:R:F385	R:R:F386	5.36	Yes	No	0	5	5
323	R:R:F385	R:R:T389	7.78	Yes	No	0	5	5
324	R:R:V387	R:R:Y391	3.79	No	Yes	0	9	8
325	R:R:F393	R:R:T389	3.89	No	No	0	8	5
326	R:R:I390	R:R:Y391	7.25	No	Yes	0	8	8
327	R:R:N395	R:R:V398	5.91	No	No	0	9	9
328	R:R:Q405	R:R:Q408	6.4	No	No	0	4	7
329	L:L:T6	R:R:M306	3.01	Yes	No	0	0	4
330	R:R:F119	R:R:W128	3.01	No	Yes	0	4	5
331	R:R:K120	R:R:T127	3	No	No	0	1	4
332	R:R:K185	R:R:T182	3	No	No	0	6	5
333	L:L:N21	L:L:S20	2.98	No	No	0	0	0
334	R:R:Y149	R:R:Y150	2.98	No	No	0	5	4
335	R:R:L176	R:R:V398	2.98	No	No	0	9	9
336	R:R:L316	R:R:V320	2.98	No	No	0	9	7
337	R:R:I276	R:R:I300	2.94	No	No	0	5	8
338	R:R:I192	R:R:M196	2.92	Yes	No	0	7	4
339	R:R:I197	R:R:M229	2.92	No	No	0	5	4
340	L:L:G24	R:R:Y41	2.9	No	No	0	0	3
341	R:R:M48	R:R:M49	2.89	No	No	0	6	4
342	R:R:F386	R:R:P350	2.89	No	No	0	5	9
343	R:R:E294	R:R:S292	2.87	No	No	0	3	4
344	R:R:I192	R:R:L167	2.85	Yes	No	0	7	6
345	R:R:I198	R:R:L202	2.85	Yes	No	0	7	7
346	R:R:K343	R:R:L339	2.82	No	No	0	8	6
347	L:L:G33	R:R:W128	2.81	No	Yes	0	0	5
348	L:L:K1	L:L:N3	2.8	No	No	0	0	0
349	R:R:P38	R:R:Y41	2.78	No	No	0	5	3
350	L:L:A8	L:L:R11	2.77	No	No	0	0	0
351	L:L:L12	L:L:L16	2.77	No	No	0	0	0
352	L:L:F15	R:R:A145	2.77	No	No	0	0	4
353	R:R:D50	R:R:K54	2.77	No	No	0	2	4
354	R:R:A278	R:R:F224	2.77	No	No	0	6	5
355	R:R:L244	R:R:L348	2.77	No	No	0	9	9
356	R:R:H245	R:R:V250	2.77	Yes	No	0	8	5
357	R:R:L316	R:R:L348	2.77	No	No	0	9	9
358	R:R:L348	R:R:L352	2.77	No	No	0	9	9
359	R:R:M49	R:R:Q52	2.72	No	Yes	0	4	6
360	R:R:E114	R:R:K115	2.7	No	No	0	2	5
361	R:R:A51	R:R:Y98	2.67	No	Yes	0	8	4
362	R:R:H156	R:R:I199	2.65	Yes	No	0	7	7
363	R:R:E397	R:R:L176	2.65	No	No	0	9	9
364	R:R:H277	R:R:I300	2.65	Yes	No	0	7	8
365	L:L:R11	R:R:V293	2.62	No	Yes	0	0	6
366	R:R:H201	R:R:L222	2.57	Yes	No	0	6	6
367	R:R:M48	R:R:R45	2.48	No	No	0	6	7
368	R:R:M337	R:R:R328	2.48	No	No	0	7	6
369	R:R:S91	R:R:W82	2.47	No	Yes	0	5	9
370	R:R:F382	R:R:L158	2.44	Yes	No	0	7	4
371	L:L:N22	R:R:F137	2.42	No	Yes	0	0	1
372	R:R:E210	R:R:R214	2.33	No	No	0	3	4
373	R:R:D50	R:R:Y53	2.3	No	No	0	2	1
374	R:R:D97	R:R:Y98	2.3	No	Yes	0	2	4
375	R:R:L264	R:R:W261	2.28	No	No	0	3	2
376	R:R:Q52	R:R:Y53	2.25	Yes	No	0	6	1
377	R:R:F224	R:R:F225	2.14	No	No	0	5	5
378	R:R:F313	R:R:F314	2.14	Yes	No	0	6	5
379	R:R:G268	R:R:P270	2.03	No	Yes	0	6	9
380	R:R:G369	R:R:P363	2.03	No	Yes	0	4	7
381	R:R:F409	R:R:W406	2	No	No	0	3	6
382	R:R:C178	R:R:G177	1.96	No	No	0	8	7
383	L:L:P28	L:L:P29	1.95	No	No	0	0	0
384	R:R:A87	R:R:P70	1.87	No	No	0	4	1
385	R:R:A231	R:R:P270	1.87	No	Yes	0	5	9
386	R:R:G44	R:R:V43	1.84	No	No	0	4	2
387	R:R:G116	R:R:V117	1.84	No	No	0	9	5
388	R:R:G168	R:R:V171	1.84	No	No	0	1	4
389	R:R:G88	R:R:T85	1.82	No	Yes	0	8	7
390	R:R:C289	R:R:V212	1.71	No	No	0	9	3
391	R:R:G268	R:R:L264	1.71	No	No	0	6	3
392	L:L:A13	R:R:V206	1.7	No	No	0	0	3
393	L:L:G33	L:L:N35	1.7	No	No	0	0	0
394	R:R:A251	R:R:V250	1.7	No	No	0	6	5
395	R:R:A341	R:R:V324	1.7	No	Yes	0	9	5
396	R:R:I301	R:R:P273	1.69	No	No	0	7	6
397	R:R:D103	R:R:P104	1.61	Yes	No	0	3	3
398	R:R:V320	R:R:V324	1.6	No	Yes	0	7	5
399	R:R:A344	R:R:L323	1.58	No	No	0	9	9
400	R:R:T400	R:R:T401	1.57	No	Yes	0	4	7
401	R:R:I199	R:R:S157	1.55	No	No	0	7	7
402	R:R:A87	R:R:D113	1.54	No	No	0	4	5
403	R:R:I153	R:R:V203	1.54	No	No	0	7	3
404	R:R:I160	R:R:V164	1.54	No	No	0	5	4
405	R:R:I192	R:R:V164	1.54	Yes	No	0	7	4
406	R:R:I199	R:R:V203	1.54	No	No	0	7	3
407	R:R:I221	R:R:V217	1.54	No	No	0	4	3
408	R:R:I248	R:R:V249	1.54	No	No	0	7	6
409	R:R:I248	R:R:V322	1.54	No	No	0	7	8
410	R:R:K366	R:R:S105	1.53	No	No	0	3	1
411	R:R:K47	R:R:V43	1.52	No	No	0	4	2
412	R:R:K143	R:R:V147	1.52	No	No	0	1	4
413	R:R:I276	R:R:T275	1.52	No	No	0	5	3
414	R:R:I279	R:R:T280	1.52	No	No	0	3	4
415	R:R:K326	R:R:V322	1.52	No	No	0	9	8
416	R:R:M327	R:R:V324	1.52	No	Yes	0	7	5
417	R:R:L151	R:R:S378	1.5	No	No	0	5	5
418	R:R:L238	R:R:V311	1.49	No	No	0	8	6
419	R:R:I165	R:R:I169	1.47	No	No	0	5	8
420	R:R:L297	R:R:T280	1.47	No	No	0	4	4
421	R:R:A333	R:R:H336	1.46	No	No	0	5	6
422	R:R:I371	R:R:M367	1.46	No	No	0	5	4
423	R:R:N396	R:R:T400	1.46	No	No	0	6	4
424	R:R:D83	R:R:T85	1.45	No	Yes	0	5	7
425	R:R:F235	R:R:P304	1.44	Yes	No	0	5	9
426	R:R:I200	R:R:L222	1.43	No	No	0	6	6
427	R:R:E140	R:R:T138	1.41	No	No	0	2	2
428	R:R:L323	R:R:M327	1.41	No	No	0	9	7
429	R:R:M367	R:R:N365	1.4	No	No	0	4	4
430	R:R:D50	R:R:K46	1.38	No	No	0	2	4
431	R:R:E106	R:R:M133	1.35	Yes	No	0	4	5
432	R:R:N396	R:R:Q399	1.32	No	No	0	6	7
433	R:R:F39	R:R:V42	1.31	No	No	0	4	1
434	R:R:R45	R:R:V42	1.31	No	No	0	7	1
435	R:R:F382	R:R:V154	1.31	Yes	No	0	7	6
436	R:R:A407	R:R:W406	1.3	No	No	0	4	6
437	L:L:T4	R:R:Y299	1.25	No	No	0	0	7
438	R:R:Q408	R:R:R404	1.17	No	No	0	7	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:T6	4.87	4	0	0
2	L:L:C7	5.295	4	3	0
3	L:L:S19	5.32	4	8	0
4	L:L:Y37	8.73	4	1	0
5	R:R:Q52	7.355	4	0	6
6	R:R:R74	4.8575	4	9	4
7	R:R:D77	5.576	5	1	9
8	R:R:W79	9.886	5	1	6
9	R:R:W82	8.12714	7	1	9
10	R:R:T85	2.5375	4	0	7
11	R:R:Y98	4.536	5	0	4
12	R:R:F99	7.14	4	1	5
13	R:R:D101	7.16	4	1	4
14	R:R:F102	6.512	5	1	4
15	R:R:D103	4.2225	4	11	3
16	R:R:E106	4.878	5	11	4
17	R:R:W118	7.952	5	1	9
18	R:R:H121	10.43	4	0	4
19	R:R:W128	4.512	5	0	5
20	R:R:S129	5.9	4	1	7
21	R:R:Y131	6.59	8	1	5
22	R:R:F137	6.062	5	8	1
23	R:R:L148	6.1675	4	4	5
24	R:R:H156	10.1475	4	0	7
25	R:R:F170	5.555	4	0	8
26	R:R:F173	5.01	5	0	7
27	R:R:T190	4.79	4	2	9
28	R:R:Y191	7.74333	6	2	8
29	R:R:I192	2.8975	4	0	7
30	R:R:I198	6.552	5	0	7
31	R:R:H201	5.5675	4	0	6
32	R:R:P216	5.175	4	12	4
33	R:R:Q227	7	4	3	7
34	R:R:N233	7.2425	4	2	9
35	R:R:Y234	6.598	5	0	7
36	R:R:F235	4.43	5	7	5
37	R:R:W236	7.49333	6	2	9
38	R:R:M237	4.5075	4	2	9
39	R:R:Y243	7.33833	6	6	8
40	R:R:H245	10.054	5	13	8
41	R:R:Q257	6.572	5	6	5
42	R:R:Y262	5.2125	4	6	7
43	R:R:W267	7.19	4	2	9
44	R:R:P270	3.14	4	7	9
45	R:R:H277	7.6525	4	0	7
46	R:R:R281	9.225	4	5	7
47	R:R:W290	6.62	4	5	9
48	R:R:V293	4.2125	4	3	6
49	R:R:H302	6.42	4	3	6
50	R:R:F313	5.8625	4	0	6
51	R:R:V324	2.84	4	0	5
52	R:R:I354	6.44	4	0	6
53	R:R:Q355	7.0775	4	2	8
54	R:R:F356	7.712	5	2	7
55	R:R:P363	4.8275	4	0	7
56	R:R:Y374	6.915	4	4	6
57	R:R:M376	5.89	4	0	7
58	R:R:H381	8.3175	4	0	9
59	R:R:F382	4.1075	4	0	7
60	R:R:Q383	6.975	4	2	9
61	R:R:F385	5.82	4	0	5
62	R:R:Y391	7.8875	4	0	8
63	R:R:T401	3.27	4	0	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:C2	R:R:L298	14.723	3.17	No	No	0	0	6
2	R:R:H277	R:R:L298	13.9279	5.14	Yes	No	0	7	6
3	L:L:C2	L:L:C7	10.5812	7.28	No	Yes	3	0	0
4	R:R:R281	R:R:W290	10.3385	12	Yes	Yes	5	7	9
5	R:R:H223	R:R:W290	11.8353	5.29	No	Yes	0	5	9
6	R:R:H223	R:R:Q227	26.1664	8.65	No	Yes	0	5	7
7	L:L:T6	R:R:H302	40.2333	9.58	Yes	Yes	0	0	6
8	R:R:M230	R:R:Y234	55.4597	5.99	No	Yes	0	6	7
9	R:R:M230	R:R:Q227	16.3849	5.44	No	Yes	3	6	7
10	L:L:Q10	R:R:H226	15.4292	6.18	No	No	0	0	6
11	R:R:H226	R:R:I198	16.0899	3.98	No	Yes	0	6	7
12	R:R:H156	R:R:H381	17.2917	9.55	Yes	Yes	0	7	9
13	R:R:H377	R:R:H381	19.5699	9.55	No	Yes	0	7	9
14	L:L:L12	R:R:H377	15.4679	5.14	No	No	4	0	7
15	L:L:N14	R:R:V293	91.0796	7.39	No	Yes	0	0	6
16	L:L:N14	L:L:R18	90.4577	8.44	No	No	0	0	0
17	L:L:F15	R:R:F137	15.8666	7.5	No	Yes	8	0	1
18	L:L:R18	R:R:F137	89.8665	9.62	No	Yes	0	0	1
19	L:L:F15	R:R:A145	17.8589	2.77	No	No	0	0	4
20	L:L:L16	R:R:A145	17.982	3.15	No	No	0	0	4
21	R:R:H201	R:R:H223	15.3358	3.58	Yes	No	0	6	5
22	R:R:H201	R:R:L291	11.947	6.43	Yes	No	0	6	6
23	R:R:C289	R:R:L291	11.2624	3.17	No	No	0	9	6
24	R:R:M48	R:R:Y98	30.6864	4.79	No	Yes	0	6	4
25	R:R:P96	R:R:Y98	36.546	6.95	No	Yes	0	9	4
26	R:R:P96	R:R:Y131	37.5051	6.95	No	Yes	0	9	5
27	R:R:V108	R:R:Y131	71.823	10.09	No	Yes	0	7	5
28	R:R:C95	R:R:V108	90.0522	3.42	No	No	0	9	7
29	R:R:C134	R:R:C95	90.829	7.28	No	No	0	9	9
30	R:R:C134	R:R:E106	91.6036	3.04	No	Yes	0	9	4
31	R:R:D103	R:R:E106	94.2179	6.5	Yes	Yes	11	3	4
32	R:R:A136	R:R:D103	99.2505	4.63	No	Yes	0	2	3
33	R:R:A136	R:R:F137	100	4.16	No	Yes	0	2	1
34	L:L:V32	R:R:Y131	26.7132	3.79	No	Yes	0	0	5
35	L:L:V32	R:R:W128	23.6821	3.68	No	Yes	0	0	5
36	R:R:V108	R:R:W82	20.0369	4.9	No	Yes	0	7	9
37	R:R:M48	R:R:M49	22.7036	2.89	No	No	0	6	4
38	R:R:M49	R:R:Q52	21.6954	2.72	No	Yes	0	4	6
39	R:R:W118	R:R:W82	16.1172	4.69	Yes	Yes	1	9	9
40	R:R:F119	R:R:W128	10.4559	3.01	No	Yes	0	4	5
41	R:R:M237	R:R:Y234	92.2757	4.79	Yes	Yes	0	9	7
42	R:R:M237	R:R:Y191	65.8302	3.59	Yes	Yes	2	9	8
43	R:R:V387	R:R:Y191	82.255	3.79	No	Yes	0	9	8
44	R:R:F188	R:R:V387	80.2445	3.93	No	No	0	8	9
45	R:R:F188	R:R:L163	38.3674	6.09	No	No	0	8	8
46	R:R:A388	R:R:L163	50.3372	3.15	No	No	0	8	8
47	R:R:A388	R:R:S166	49.7198	3.42	No	No	0	8	9
48	R:R:F393	R:R:S166	85.7133	5.28	No	No	0	8	9
49	R:R:F393	R:R:T389	84.5662	3.89	No	No	0	8	5
50	R:R:F385	R:R:T389	83.4169	7.78	Yes	No	0	5	5
51	R:R:F170	R:R:F188	41.9989	6.43	Yes	No	0	8	8
52	R:R:C392	R:R:F170	37.7284	5.59	No	Yes	0	9	8
53	R:R:C392	R:R:S166	37.2124	6.89	No	No	0	9	9
54	R:R:H156	R:R:S195	15.7094	11.16	Yes	No	0	7	7
55	R:R:I160	R:R:S195	14.8881	3.1	No	No	0	5	7
56	R:R:M237	R:R:N233	27.5436	4.21	Yes	Yes	2	9	9
57	R:R:N233	R:R:T190	53.6736	4.39	Yes	Yes	2	9	9
58	R:R:T190	R:R:W236	50.1583	3.64	Yes	Yes	2	9	9
59	R:R:L183	R:R:W236	27.1119	4.56	No	Yes	0	8	9
60	R:R:L183	R:R:Y243	26.2052	7.03	No	Yes	0	8	8
61	R:R:R180	R:R:Y243	18.3499	4.12	No	Yes	0	9	8
62	R:R:N395	R:R:R180	17.4033	3.62	No	No	0	9	9
63	R:R:N395	R:R:V398	16.4783	5.91	No	No	0	9	9
64	R:R:L176	R:R:V398	15.5272	2.98	No	No	0	9	9
65	R:R:L176	R:R:T401	13.618	4.42	No	Yes	0	9	7
66	R:R:I160	R:R:V164	14.5532	1.54	No	No	0	5	4
67	R:R:I192	R:R:V164	14.3243	1.54	Yes	No	0	7	4
68	R:R:I192	R:R:L163	14.3414	4.28	Yes	No	0	7	8
69	R:R:I198	R:R:N194	17.6061	5.66	Yes	No	0	7	8
70	R:R:H277	R:R:I301	10.7532	9.28	Yes	No	0	7	7
71	R:R:C239	R:R:W236	19.8079	5.22	No	Yes	0	7	9
72	R:R:C239	R:R:L265	18.8796	4.76	No	No	0	7	7
73	R:R:F235	R:R:L265	11.3056	3.65	Yes	No	7	5	7
74	R:R:F385	R:R:F386	74.14	5.36	Yes	No	0	5	5
75	R:R:F386	R:R:P350	72.9701	2.89	No	No	0	5	9
76	R:R:P350	R:R:V349	71.798	3.53	No	No	0	9	8
77	R:R:I354	R:R:V349	70.6236	10.75	Yes	No	0	6	8
78	R:R:I354	R:R:L352	23.7424	4.28	Yes	No	0	6	9
79	R:R:I354	R:R:L316	39.895	5.71	Yes	No	0	6	9
80	R:R:L316	R:R:L348	20.3023	2.77	No	No	0	9	9
81	R:R:L244	R:R:L348	37.75	2.77	No	No	0	9	9
82	R:R:I319	R:R:L244	35.2588	4.28	No	No	0	9	9
83	R:R:L348	R:R:L352	20.0551	2.77	No	No	0	9	9
84	R:R:H245	R:R:I319	32.755	3.98	Yes	No	0	8	9
85	R:R:H245	R:R:V249	10.1005	15.22	Yes	No	13	8	6
86	R:R:H245	R:R:N318	10.1005	10.2	Yes	No	13	8	8
87	R:R:L316	R:R:V320	19.0288	2.98	No	No	0	9	7
88	R:R:V320	R:R:V324	16.5114	1.6	No	Yes	0	7	5
89	L:L:C7	R:R:H302	82.6423	5.9	Yes	Yes	3	0	6
90	L:L:T6	R:R:Y234	40.5067	3.75	Yes	Yes	0	0	7
91	R:R:H302	R:R:M230	39.0486	5.25	Yes	No	3	6	6
92	L:L:C7	L:L:Q10	16.852	4.58	Yes	No	0	0	0
93	L:L:L12	L:L:L16	18.2462	2.77	No	No	0	0	0
94	R:R:N194	R:R:N233	17.6528	4.09	No	Yes	0	8	9
95	L:L:C7	R:R:V293	87.987	3.42	Yes	Yes	3	0	6
96	R:R:N233	R:R:Y191	16.3473	16.28	Yes	Yes	2	9	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:K1	R:R:E294	5.4	0	No	No	0	3	0	1
L:L:C2	R:R:V293	3.42	3	No	Yes	0	6	0	1
L:L:C2	R:R:L298	3.17	3	No	No	0	6	0	1
L:L:A5	R:R:M376	3.22	0	No	Yes	0	7	0	1
L:L:T6	R:R:Y234	3.75	0	Yes	Yes	0	7	0	1
L:L:T6	R:R:H302	9.58	0	Yes	Yes	0	6	0	1
L:L:C7	R:R:V293	3.42	3	Yes	Yes	0	6	0	1
L:L:C7	R:R:H302	5.9	3	Yes	Yes	0	6	0	1
L:L:T9	R:R:I198	3.04	0	No	Yes	0	7	0	1
L:L:T9	R:R:H381	6.85	0	No	Yes	0	9	0	1
L:L:Q10	R:R:H226	6.18	0	No	No	0	6	0	1
L:L:Q10	R:R:Q227	8.96	0	No	Yes	0	7	0	1
L:L:L12	R:R:L148	4.15	4	No	Yes	0	5	0	1
L:L:L12	R:R:H377	5.14	4	No	No	0	7	0	1
L:L:N14	R:R:V293	7.39	0	No	Yes	0	6	0	1
L:L:F15	R:R:F137	7.5	8	No	Yes	0	1	0	1
L:L:L16	R:R:A145	3.15	0	No	No	0	4	0	1
L:L:V17	R:R:V206	4.81	0	No	No	0	3	0	1
L:L:V17	R:R:V212	3.21	0	No	No	0	3	0	1
L:L:R18	R:R:F137	9.62	0	No	Yes	0	1	0	1
L:L:S19	R:R:F137	6.61	8	Yes	Yes	0	1	0	1
L:L:S19	R:R:L142	4.5	8	Yes	No	0	2	0	1
L:L:S20	R:R:Y146	5.09	0	No	No	0	2	0	1
L:L:N21	R:R:G209	6.79	0	No	No	0	3	0	1
L:L:L23	R:R:V212	4.47	0	No	No	0	3	0	1
L:L:L23	R:R:N288	4.12	0	No	No	0	4	0	1
L:L:L27	R:R:R213	8.5	0	No	No	0	2	0	1
L:L:T30	R:R:F99	11.67	1	No	Yes	0	5	0	1
L:L:T30	R:R:D101	10.12	1	No	Yes	0	4	0	1
L:L:T30	R:R:F102	6.49	1	No	Yes	0	4	0	1
L:L:V32	R:R:W128	3.68	0	No	Yes	0	5	0	1
L:L:V32	R:R:Y131	3.79	0	No	Yes	0	5	0	1
L:L:V32	R:R:T132	3.17	0	No	No	0	6	0	1
L:L:S34	R:R:H121	12.55	0	No	Yes	0	4	0	1
L:L:S34	R:R:N124	8.94	0	No	No	0	5	0	1
L:L:Y37	R:R:G78	8.69	1	Yes	No	0	5	0	1
L:L:Y37	R:R:W79	12.54	1	Yes	Yes	0	6	0	1
L:L:?38	R:R:W79	11.28	1	No	Yes	0	6	0	1
R:R:R45	R:R:Y41	4.12	0	No	No	7	3	2	1
R:R:D77	R:R:G78	3.35	1	Yes	No	9	5	2	1
R:R:D77	R:R:L80	5.43	1	Yes	No	9	5	2	2
R:R:D77	R:R:S129	4.42	1	Yes	Yes	9	7	2	2
R:R:D77	R:R:Y131	5.75	1	Yes	Yes	9	5	2	1
R:R:F99	R:R:W79	9.02	1	Yes	Yes	5	6	1	1
R:R:F102	R:R:W79	5.01	1	Yes	Yes	4	6	1	1
R:R:W79	R:R:Y131	11.58	1	Yes	Yes	6	5	1	1
R:R:L80	R:R:Y131	3.52	1	No	Yes	5	5	2	1
R:R:P96	R:R:Y131	6.95	0	No	Yes	9	5	2	1
R:R:D101	R:R:F99	3.58	1	Yes	Yes	4	5	1	1
R:R:F102	R:R:F99	4.29	1	Yes	Yes	4	5	1	1
R:R:D101	R:R:F102	9.55	1	Yes	Yes	4	4	1	1
R:R:D101	R:R:N135	5.39	1	Yes	No	4	3	1	2
R:R:F102	R:R:Y131	7.22	1	Yes	Yes	4	5	1	1
R:R:V108	R:R:Y131	10.09	0	No	Yes	7	5	2	1
R:R:H121	R:R:P122	10.68	0	Yes	No	4	5	1	2
R:R:E123	R:R:H121	11.08	0	No	Yes	4	4	2	1
R:R:H121	R:R:W128	7.41	0	Yes	Yes	4	5	1	1
R:R:N124	R:R:R126	8.44	0	No	No	5	4	1	2
R:R:N130	R:R:W128	5.65	0	No	Yes	8	5	2	1
R:R:S129	R:R:Y131	3.82	1	Yes	Yes	7	5	2	1
R:R:N130	R:R:T132	5.85	0	No	No	8	6	2	1
R:R:A136	R:R:F137	4.16	0	No	Yes	2	1	2	1
R:R:L142	R:R:Y146	10.55	0	No	No	2	2	1	1
R:R:D373	R:R:L148	5.43	0	No	Yes	5	5	2	1
R:R:L148	R:R:Y374	3.52	4	Yes	Yes	5	6	1	2
R:R:H377	R:R:L148	11.57	4	No	Yes	7	5	1	1
R:R:A152	R:R:H381	7.32	0	No	Yes	7	9	2	1
R:R:H156	R:R:I198	17.23	0	Yes	Yes	7	7	2	1
R:R:H156	R:R:H381	9.55	0	Yes	Yes	7	9	2	1
R:R:I198	R:R:N194	5.66	0	Yes	No	7	8	1	2
R:R:H226	R:R:I197	3.98	0	No	No	6	5	1	2
R:R:H226	R:R:I198	3.98	0	No	Yes	6	7	1	1
R:R:P207	R:R:V206	3.53	0	No	No	3	3	2	1
R:R:D215	R:R:N288	12.12	0	No	No	6	4	2	1
R:R:H223	R:R:Q227	8.65	0	No	Yes	5	7	2	1
R:R:M230	R:R:Q227	5.44	3	No	Yes	6	7	2	1
R:R:H302	R:R:Q227	4.95	3	Yes	Yes	6	7	1	1
R:R:M230	R:R:Y234	5.99	3	No	Yes	6	7	2	1
R:R:H302	R:R:M230	5.25	3	Yes	No	6	6	1	2
R:R:M237	R:R:Y234	4.79	2	Yes	Yes	9	7	2	1
R:R:V305	R:R:Y234	5.05	0	No	Yes	7	7	2	1
R:R:F356	R:R:Y234	13.41	2	Yes	Yes	7	7	2	1
R:R:H277	R:R:L298	5.14	0	Yes	No	7	6	2	1
R:R:H296	R:R:Y299	3.27	0	No	No	2	7	2	1
R:R:F356	R:R:I380	6.28	2	Yes	No	7	6	2	2
R:R:F359	R:R:M376	3.73	0	No	Yes	6	7	2	1
R:R:M376	R:R:Y372	10.78	0	Yes	No	7	7	1	2
R:R:I380	R:R:M376	5.83	0	No	Yes	6	7	2	1
R:R:H377	R:R:H381	9.55	4	No	Yes	7	9	1	1
L:L:T6	R:R:M306	3.01	0	Yes	No	0	4	0	1
R:R:F119	R:R:W128	3.01	0	No	Yes	4	5	2	1
L:L:G24	R:R:Y41	2.9	0	No	No	0	3	0	1
R:R:E294	R:R:S292	2.87	0	No	No	3	4	1	2
R:R:I198	R:R:L202	2.85	0	Yes	No	7	7	1	2
L:L:G33	R:R:W128	2.81	0	No	Yes	0	5	0	1
R:R:P38	R:R:Y41	2.78	0	No	No	5	3	2	1
L:L:F15	R:R:A145	2.77	8	No	No	0	4	0	1
L:L:R11	R:R:V293	2.62	0	No	Yes	0	6	0	1
L:L:N22	R:R:F137	2.42	0	No	Yes	0	1	0	1
R:R:C289	R:R:V212	1.71	0	No	No	9	3	2	1
L:L:A13	R:R:V206	1.7	0	No	No	0	3	0	1
L:L:T4	R:R:Y299	1.25	0	No	No	0	7	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7TYI_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.04
Number of Linked Nodes	382
Number of Links	438
Number of Hubs	63
Number of Links mediated by Hubs	233
Number of Communities	13
Number of Nodes involved in Communities	72
Number of Links involved in Communities	94

Path Summary
Number Of Nodes in MetaPath	97
Number Of Links MetaPath	96
Number of Shortest Paths	174593
Length Of Smallest Path	3
Average Path Length	23.3044
Length of Longest Path	49
Minimum Path Strength	1.31
Average Path Strength	5.51578
Maximum Path Strength	17.25
Minimum Path Correlation	0.7
Average Path Correlation	0.955153
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	2.27273
Average % Of Corr. Nodes	45.7382
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	41.653
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • molecular function activator activity • phosphorus-oxygen lyase activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • adenylate cyclase activator activity • adenylate cyclase activity • cation binding • metal ion binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • biological regulation • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of biological process • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • protein localization • regulation of localization • establishment of protein localization • nitrogen compound transport • localization • cellular macromolecule localization • regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • protein transport • regulation of cellular localization • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • signaling receptor binding • molecular transducer activity • molecular function activator activity • signaling receptor activity • molecular function regulator activity • signaling receptor regulator activity • receptor ligand activity • signaling receptor activator activity • hormone activity • lipid binding • identical protein binding • positive regulation of cell communication • positive regulation of signal transduction • positive regulation of biological process • regulation of signal transduction • positive regulation of response to stimulus • regulation of intracellular signal transduction • regulation of calcium-mediated signaling • positive regulation of calcium-mediated signaling • positive regulation of cellular process • regulation of signaling • positive regulation of intracellular signal transduction • regulation of response to stimulus • calcium-mediated signaling • regulation of cell communication • positive regulation of signaling • behavior • eating behavior • feeding behavior • amylin receptor 1 signaling pathway • amylin receptor signaling pathway • calcitonin family receptor signaling pathway • myeloid leukocyte differentiation • regulation of leukocyte differentiation • cellular developmental process • regulation of developmental process • negative regulation of biological process • cell development • regulation of cell differentiation • regulation of cell development • regulation of osteoclast differentiation • cell differentiation • osteoclast differentiation • negative regulation of cellular process • regulation of immune system process • regulation of multicellular organismal process • negative regulation of cell differentiation • negative regulation of hemopoiesis • regulation of multicellular organismal development • negative regulation of leukocyte differentiation • hemopoiesis • regulation of myeloid cell differentiation • negative regulation of developmental process • regulation of myeloid leukocyte differentiation • negative regulation of myeloid cell differentiation • negative regulation of osteoclast differentiation • negative regulation of myeloid leukocyte differentiation • negative regulation of cell development • myeloid cell differentiation • negative regulation of immune system process • immune system process • regulation of hemopoiesis • negative regulation of multicellular organismal process • leukocyte differentiation • monosaccharide metabolic process • carbohydrate metabolic process • hexose metabolic process • small molecule metabolic process • metabolic process • primary metabolic process • glucose metabolic process • negative regulation of tissue remodeling • homeostatic process • negative regulation of bone remodeling • regulation of bone remodeling • tissue homeostasis • regulation of tissue remodeling • regulation of bone resorption • bone resorption • negative regulation of bone resorption • multicellular organismal-level homeostasis • tissue remodeling • bone remodeling • anatomical structure homeostasis • amylin receptor 2 signaling pathway • sensory perception of pain • positive regulation of cAMP/PKA signal transduction • cAMP/PKA signal transduction • regulation of cAMP/PKA signal transduction • amylin receptor 3 signaling pathway • intracellular vesicle • cytoplasmic vesicle • secretory granule • secretory vesicle • somatodendritic compartment • cell body • neuronal cell body • amide binding • amyloid-beta binding • peptide binding • calcitonin family receptor activity • peptide receptor activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • transmembrane signaling receptor activity • calcitonin receptor activity • amylin receptor activity • calcitonin gene-related peptide receptor activity • calcitonin binding • calcitonin family binding • peptide hormone binding • hormone binding • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • catabolic process • RNA metabolic process • macromolecule catabolic process • regulation of primary metabolic process • nucleobase-containing compound metabolic process • post-transcriptional regulation of gene expression • regulation of RNA metabolic process • regulation of mRNA catabolic process • regulation of nucleobase-containing compound metabolic process • RNA catabolic process • negative regulation of macromolecule metabolic process • regulation of biosynthetic process • mRNA catabolic process • negative regulation of metabolic process • regulation of macromolecule metabolic process • regulation of catabolic process • gene expression • mRNA metabolic process • macromolecule biosynthetic process • nucleic acid metabolic process • nucleobase-containing compound catabolic process • regulation of mRNA stability • regulation of gene expression • negative regulation of gene expression • biosynthetic process • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • regulation of RNA stability • nucleic acid catabolic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • regulation of mRNA metabolic process • regulation of metabolic process • positive regulation of ERK1 and ERK2 cascade • positive regulation of MAPK cascade • regulation of MAPK cascade • MAPK cascade • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of macromolecule biosynthetic process • positive regulation of metabolic process • positive regulation of gene expression • positive regulation of biosynthetic process • positive regulation of macromolecule metabolic process • regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • phosphatidylinositol 3-kinase/protein kinase B signal transduction • response to corticosteroid • response to steroid hormone • response to glucocorticoid • response to amyloid-beta • cell surface receptor signaling pathway • calcitonin gene-related peptide receptor signaling pathway • ossification • regulation of ossification • negative regulation of ossification • amylin receptor complex • amylin receptor complex 3 • receptor complex • plasma membrane signaling receptor complex • G protein-coupled receptor complex • calcitonin family receptor complex • amylin receptor complex 2 • amylin receptor complex 1 • axon • acrosomal vesicle
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	NH2
PDB Residues	L:L:?38
Environment Details	Open EMBL-EBI Page
Code	NH2
Name	AMINO GROUP
Synonyms
Identifier
Formula	H2 N
Molecular Weight	16.023
SMILES
PubChem	123329
Formal Charge	0
Total Atoms	3
Total Chiral Atoms	0
Total Bonds	2
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P30988
Sequence	>7TYI_nogp_Chain_R P F L Y V V G R K K M M D A Q Y K C Y D R M Q Q L P A P Y C N R T W D G W L C W D D T P A G V L S Y Q F C P D Y F P D F D P S E K V T K Y C D E K G V W F K H P E N N R T W S N Y T M C N A F T P E K L K N A Y V L Y Y L A I V G H S L S I F T L V I S L G I F V F F R S L G C Q R V T L H K N M F L T Y I L N S M I I I I H L V E V V P N G E L V R R D P V S C K I L H F F H Q Y M M A C N Y F W M L C E G I Y L H T L I V V A V F T E K Q R L R W Y Y L L G W G F P L V P T T I H A I T R A V Y F N D N C W L S V E T H L L Y I I H G P V M A A L V V N F F F L L N I V R V L V T K M R E T H E A E S H M Y L K A V K A T M I L V P L L G I Q F V V F P W R P S N K M L G K I Y D Y V M H S L I H F Q G F F V A T I Y C F C N N E V Q T T V K R Q W A Q F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9AUC	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Calcitonin gene-related peptide-1	-	Gs/β1/γ2; RAMP1	2.4	2024-04-24	10.1021/acs.biochem.4c00114
	9AUC (No Gprot)	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Calcitonin gene-related peptide-1	-		2.4	2024-04-24	10.1021/acs.biochem.4c00114
	8F0J	B1	Peptide	Calcitonin	CT	Homo sapiens	Pramlintide Analogue San45	-	Gs/β1/γ2	2	2023-08-02	10.1038/s41589-023-01393-4
	8F0J (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	Pramlintide Analogue San45	-		2	2023-08-02	10.1038/s41589-023-01393-4
	8F2B	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Pramlintide Analogue San45	-	Gs/β1/γ2; RAMP3	2	2023-08-02	10.1038/s41589-023-01393-4
	8F2B (No Gprot)	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Pramlintide Analogue San45	-		2	2023-08-02	10.1038/s41589-023-01393-4
	8F2A	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Pramlintide Analogue San385	-	Gs/β1/γ2; RAMP3	2.2	2023-08-02	10.1038/s41589-023-01393-4
	8F2A (No Gprot)	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Pramlintide Analogue San385	-		2.2	2023-08-02	10.1038/s41589-023-01393-4
	8F0K	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Pramlintide Analogue San385	-	Gs/β1/γ2; RAMP3	1.9	2023-08-02	10.1038/s41589-023-01393-4
	8F0K (No Gprot)	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Pramlintide Analogue San385	-		1.9	2023-08-02	10.1038/s41589-023-01393-4
	7X5H	A	Amine	5-Hydroxytryptamine	5-HT_5A	Homo sapiens	5-CT	-	Gi1/β1/γ2	3.1	2022-09-14	10.1038/s41421-022-00412-3
	7X5H (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_5A	Homo sapiens	5-CT	-		3.1	2022-09-14	10.1038/s41421-022-00412-3
	7XTC	A	Amine	5-Hydroxytryptamine	5-HT₇	Homo sapiens	5-CT	-	Gs/β1/γ2	3.2	2022-07-27	10.1016/j.molcel.2022.05.031
	7XTC (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT₇	Homo sapiens	5-CT	-		3.2	2022-07-27	10.1016/j.molcel.2022.05.031
	7UM5	A	Amine	5-Hydroxytryptamine	5-HT_5A	Homo sapiens	5-CT	-	chim(NtGi1-Go)/β1/γ2	2.73	2022-07-20	10.1038/s41594-022-00796-6
	7UM5 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_5A	Homo sapiens	5-CT	-		2.73	2022-07-20	10.1038/s41594-022-00796-6
	7TYN	B1	Peptide	Calcitonin	CT	Homo sapiens	Calcitonin-1	-	Gs/β1/γ2	2.6	2022-03-30	10.1126/science.abm9609
	7TYN (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	Calcitonin-1	-		2.6	2022-03-30	10.1126/science.abm9609
	7TYI	B1	Peptide	Calcitonin	CT	Homo sapiens	Amylin	-	Gs/β1/γ2	3.3	2022-03-30	10.1126/science.abm9609
	7TYI (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	Amylin	-		3.3	2022-03-30	10.1126/science.abm9609
	7TYX	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Amylin	-	Gs/β1/γ2; RAMP2	2.55	2022-03-30	10.1126/science.abm9609
	7TYX (No Gprot)	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Amylin	-		2.55	2022-03-30	10.1126/science.abm9609
	7TYO	B1	Peptide	Calcitonin	CT	Homo sapiens	Calcitonin	-	Gs/β1/γ2	2.7	2022-03-23	10.1126/science.abm9609
	7TYO (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	Calcitonin	-		2.7	2022-03-23	10.1126/science.abm9609
	7TYL	B1	Peptide	Calcitonin	CT	Homo sapiens	Amylin	-	Gs/β1/γ2	3.3	2022-03-23	10.1126/science.abm9609
	7TYL (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	Amylin	-		3.3	2022-03-23	10.1126/science.abm9609
	7TYW	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Calcitonin-1	-	Gs/β1/γ2; RAMP1	3	2022-03-23	10.1126/science.abm9609
	7TYW (No Gprot)	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Calcitonin-1	-		3	2022-03-23	10.1126/science.abm9609
	7TYF	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Amylin	-	Gs/β1/γ2; RAMP1	2.2	2022-03-23	10.1126/science.abm9609
	7TYF (No Gprot)	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Amylin	-		2.2	2022-03-23	10.1126/science.abm9609
	7TYY	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Calcitonin-1	-	Gs/β1/γ2; RAMP2	3	2022-03-23	10.1126/science.abm9609
	7TYY (No Gprot)	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Calcitonin-1	-		3	2022-03-23	10.1126/science.abm9609
	7TYH	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Calcitonin-1	-	Gs/β1/γ2; RAMP2	3.3	2022-03-23	10.1126/science.abm9609
	7TYH (No Gprot)	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Calcitonin-1	-		3.3	2022-03-23	10.1126/science.abm9609
	7TZF	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Amylin	-	Gs/β1/γ2; RAMP3	2.4	2022-03-23	10.1126/science.abm9609
	7TZF (No Gprot)	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Amylin	-		2.4	2022-03-23	10.1126/science.abm9609
	7KNU	B1	Peptide	Calcitonin	CT Like	Homo sapiens	Calcitonin gene-related peptide-1	-	RAMP1	3.49	2021-02-24	10.1126/science.abf7258
	7KNT	B1	Peptide	Calcitonin	CT Like	Homo sapiens	-	-	RAMP1	3.15	2021-02-24	10.1126/science.abf7258
	6PH7	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	Nerol	Gt(CT)	2.9	2020-07-01	To be published
	6PGS	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	Geraniol	Gt(CT)	2.9	2020-07-01	To be published
	6PEL	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	Citronellol	Gt(CT)	3.19	2020-06-24	To be published
	6UVA	B1	Peptide	Calcitonin	CT Like (AM2)	Homo sapiens	Adrenomedullin-2	-	Gs/β1/γ2; RAMP3	2.3	2020-04-01	10.1021/acsptsci.9b00080
	6UVA (No Gprot)	B1	Peptide	Calcitonin	CT Like (AM2)	Homo sapiens	Adrenomedullin-2	-		2.3	2020-04-01	10.1021/acsptsci.9b00080
	6UUS	B1	Peptide	Calcitonin	CT Like (AM2)	Homo sapiens	Adrenomedullin	-	Gs/β1/γ2; RAMP3	2.4	2020-04-01	10.1021/acsptsci.9b00080
	6UUS (No Gprot)	B1	Peptide	Calcitonin	CT Like (AM2)	Homo sapiens	Adrenomedullin	-		2.4	2020-04-01	10.1021/acsptsci.9b00080
	6UUN	B1	Peptide	Calcitonin	CT Like (AM1)	Homo sapiens	Adrenomedullin	-	Gs/β1/γ2; RAMP2	3	2020-03-25	10.1021/acsptsci.9b00080
	6UUN (No Gprot)	B1	Peptide	Calcitonin	CT Like (AM1)	Homo sapiens	Adrenomedullin	-		3	2020-03-25	10.1021/acsptsci.9b00080
	6NWE	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl-β-D-Glucopyranoside	-	Gt(CT)	2.71	2020-02-12	To be published
	6TP4	A	Peptide	Orexin	OX₁	Homo sapiens	ACT-462206	-	-	3.01	2020-01-01	10.1021/acs.jmedchem.9b01787
	6NIY	B1	Peptide	Calcitonin	CT	Homo sapiens	Adrenomedullin	-	Gs/β1/γ2	3.34	2019-01-23	10.1021/acsptsci.8b00056
	6NIY (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	Adrenomedullin	-		3.34	2019-01-23	10.1021/acsptsci.8b00056
	6E3Y	B1	Peptide	Calcitonin	CT Like	Homo sapiens	Calcitonin gene-related peptide-1	-	Gs/β1/γ2; RAMP1	3.3	2018-09-19	10.1038/s41586-018-0535-y
	6E3Y (No Gprot)	B1	Peptide	Calcitonin	CT Like	Homo sapiens	Calcitonin gene-related peptide-1	-		3.3	2018-09-19	10.1038/s41586-018-0535-y
	5WKT	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl-β-D-Glucopyranoside	-	Gt(CT)	3.2	2017-12-13	10.1038/nprot.2017.135
	5UZ7	B1	Peptide	Calcitonin	CT	Homo sapiens	-	-	Gs/β1/γ2	4.1	2017-05-03	10.1038/nature22327
	5UZ7 (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	-	-		4.1	2017-05-03	10.1038/nature22327
	5EN0	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gt(CT)	2.81	2016-08-10	10.15252/embr.201642671
	4X1H	A	Sensory	Opsins	Rhodopsin	Bos taurus	Nonyl-β-D-Glucopyranoside	-	Gt(CT)	2.29	2015-11-04	10.1016/j.str.2015.09.015
	4J4Q	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl β-D-Glucopyranoside	-	Gt(CT)	2.65	2013-10-30	10.1002/anie.201302374
	4BEY	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	Gt(CT)	2.9	2013-05-08	10.1038/embor.2013.44
	4A4M	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gt(CT)	3.3	2012-01-25	10.1073/pnas.1114089108
	2X72	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gt(CT)	3	2011-03-16	10.1038/nature09795
	3PQR	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gt(CT)	2.85	2011-03-09	10.1038/nature09789
	3DQB	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	Gt(CT)	3.2	2008-09-23	10.1038/nature07330

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