psnGPCR

Press and hold down the left mouse button and move the mouse to rotate.
Press and hold down the central mouse button and move the mouse to translate.
Use the mouse wheel to zoom in or out.
Click on any atom on your molecule and the corresponding residue label will be placed beneath the viewer.

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:K1	R:R:E294	5.4	No	No	0	0	3
2	L:L:C2	L:L:C7	7.28	No	Yes	3	0	0
3	L:L:C2	R:R:V293	3.42	No	Yes	3	0	6
4	L:L:C2	R:R:L298	3.17	No	No	0	0	6
5	L:L:T4	L:L:T6	3.14	No	Yes	0	0	0
6	L:L:A5	R:R:M376	3.22	No	Yes	0	0	7
7	L:L:T6	R:R:Y234	3.75	Yes	Yes	0	0	7
8	L:L:T6	R:R:H302	9.58	Yes	Yes	0	0	6
9	L:L:C7	L:L:Q10	4.58	Yes	No	0	0	0
10	L:L:C7	R:R:V293	3.42	Yes	Yes	3	0	6
11	L:L:C7	R:R:H302	5.9	Yes	Yes	3	0	6
12	L:L:T9	R:R:I198	3.04	No	Yes	0	0	7
13	L:L:T9	R:R:H381	6.85	No	Yes	0	0	9
14	L:L:Q10	R:R:H226	6.18	No	No	0	0	6
15	L:L:Q10	R:R:Q227	8.96	No	Yes	0	0	7
16	L:L:L12	R:R:L148	4.15	No	Yes	4	0	5
17	L:L:L12	R:R:H377	5.14	No	No	4	0	7
18	L:L:N14	L:L:R18	8.44	No	No	0	0	0
19	L:L:N14	R:R:V293	7.39	No	Yes	0	0	6
20	L:L:F15	L:L:S19	5.28	No	Yes	9	0	0
21	L:L:F15	R:R:F137	7.5	No	Yes	9	0	1
22	L:L:L16	R:R:A145	3.15	No	No	0	0	4
23	L:L:V17	R:R:V206	4.81	No	No	0	0	3
24	L:L:V17	R:R:V212	3.21	No	No	0	0	3
25	L:L:R18	R:R:F137	9.62	No	Yes	0	0	1
26	L:L:S19	L:L:S20	4.89	Yes	No	0	0	0
27	L:L:S19	R:R:F137	6.61	Yes	Yes	9	0	1
28	L:L:S19	R:R:L142	4.5	Yes	No	0	0	2
29	L:L:S20	R:R:Y146	5.09	No	No	0	0	2
30	L:L:N21	R:R:G209	6.79	No	No	0	0	3
31	L:L:L27	L:L:N22	9.61	No	No	0	0	0
32	L:L:L23	R:R:V212	4.47	No	No	0	0	3
33	L:L:L23	R:R:N288	4.12	No	No	0	0	4
34	L:L:G24	L:L:P25	4.06	No	No	0	0	0
35	L:L:P28	L:L:V26	7.07	No	No	0	0	0
36	L:L:L27	R:R:R213	8.5	No	No	0	0	2
37	L:L:T30	R:R:F99	11.67	No	Yes	1	0	5
38	L:L:T30	R:R:D101	10.12	No	Yes	1	0	4
39	L:L:T30	R:R:F102	6.49	No	Yes	1	0	4
40	L:L:N31	L:L:N35	4.09	No	No	0	0	0
41	L:L:V32	R:R:W128	3.68	No	Yes	0	0	5
42	L:L:V32	R:R:Y131	3.79	No	Yes	0	0	5
43	L:L:V32	R:R:T132	3.17	No	No	0	0	6
44	L:L:S34	R:R:H121	12.55	No	Yes	0	0	4
45	L:L:S34	R:R:N124	8.94	No	No	0	0	5
46	L:L:T36	L:L:Y37	4.99	No	Yes	1	0	0
47	L:L:?38	L:L:T36	7.3	No	No	1	0	0
48	L:L:?38	L:L:Y37	8.7	No	Yes	1	0	0
49	L:L:Y37	R:R:G78	8.69	Yes	No	0	0	5
50	L:L:Y37	R:R:W79	12.54	Yes	Yes	1	0	6
51	L:L:?38	R:R:W79	11.28	No	Yes	1	0	6
52	R:R:L40	R:R:P100	3.28	No	No	0	5	4
53	R:R:D287	R:R:L40	6.79	No	No	0	3	5
54	R:R:R45	R:R:Y41	4.12	No	No	0	7	3
55	R:R:K47	R:R:Y98	5.97	No	Yes	0	4	4
56	R:R:M48	R:R:Y98	4.79	No	Yes	0	6	4
57	R:R:Q52	R:R:Y56	12.4	Yes	No	0	6	3
58	R:R:Q52	R:R:W76	12.05	Yes	No	0	6	8
59	R:R:C55	R:R:R74	4.18	No	Yes	10	9	4
60	R:R:C55	R:R:C81	7.28	No	No	10	9	9
61	R:R:M59	R:R:Y56	5.99	No	No	0	5	3
62	R:R:Q61	R:R:R58	15.19	No	No	0	3	3
63	R:R:M59	R:R:Q60	8.16	No	No	0	5	3
64	R:R:M59	R:R:R74	3.72	No	Yes	0	5	4
65	R:R:Q60	R:R:Q61	3.84	No	No	0	3	3
66	R:R:L62	R:R:P63	3.28	No	No	0	3	1
67	R:R:D84	R:R:L62	10.86	No	No	0	4	3
68	R:R:P86	R:R:Y71	5.56	No	No	0	2	3
69	R:R:C112	R:R:C72	7.28	No	No	1	9	9
70	R:R:C72	R:R:D113	4.67	No	No	0	9	5
71	R:R:C72	R:R:W118	11.75	No	Yes	1	9	9
72	H:H:?2	R:R:N73	34.5	No	No	0	0	4
73	R:R:C81	R:R:R74	5.57	No	Yes	10	9	4
74	R:R:D84	R:R:R74	5.96	No	Yes	0	4	4
75	R:R:T75	R:R:W118	6.06	No	Yes	0	5	9
76	R:R:C81	R:R:W76	6.53	No	No	0	9	8
77	R:R:D77	R:R:G78	3.35	Yes	No	0	9	5
78	R:R:D77	R:R:L80	5.43	Yes	No	1	9	5
79	R:R:D77	R:R:W82	8.93	Yes	Yes	1	9	9
80	R:R:D77	R:R:S129	4.42	Yes	Yes	1	9	7
81	R:R:D77	R:R:Y131	5.75	Yes	Yes	1	9	5
82	R:R:F99	R:R:W79	9.02	Yes	Yes	1	5	6
83	R:R:F102	R:R:W79	5.01	Yes	Yes	1	4	6
84	R:R:W79	R:R:Y131	11.58	Yes	Yes	1	6	5
85	R:R:L80	R:R:Q93	13.31	No	No	0	5	6
86	R:R:L80	R:R:Y131	3.52	No	Yes	1	5	5
87	R:R:Q93	R:R:W82	7.67	No	Yes	0	6	9
88	R:R:V108	R:R:W82	4.9	No	Yes	0	7	9
89	R:R:K110	R:R:W82	22.05	No	Yes	1	8	9
90	R:R:W118	R:R:W82	4.69	Yes	Yes	1	9	9
91	R:R:S129	R:R:W82	6.18	Yes	Yes	1	7	9
92	R:R:P86	R:R:T85	3.5	No	Yes	0	2	7
93	R:R:C112	R:R:T85	3.38	No	Yes	0	9	7
94	R:R:L90	R:R:V89	4.47	No	No	0	4	5
95	R:R:V89	R:R:Y111	7.57	No	No	0	5	4
96	R:R:L90	R:R:Y92	7.03	No	No	11	4	4
97	R:R:L90	R:R:T109	5.9	No	No	11	4	5
98	R:R:K107	R:R:Y92	3.58	No	No	0	3	4
99	R:R:T109	R:R:Y92	6.24	No	No	11	5	4
100	R:R:F94	R:R:K107	6.2	No	No	0	3	3
101	R:R:C95	R:R:V108	3.42	No	No	0	9	7
102	R:R:C134	R:R:C95	7.28	No	No	0	9	9
103	R:R:P96	R:R:Y98	6.95	No	Yes	0	9	4
104	R:R:P96	R:R:Y131	6.95	No	Yes	0	9	5
105	R:R:D101	R:R:F99	3.58	Yes	Yes	1	4	5
106	R:R:F102	R:R:F99	4.29	Yes	Yes	1	4	5
107	R:R:D101	R:R:F102	9.55	Yes	Yes	1	4	4
108	R:R:D101	R:R:N135	5.39	Yes	No	0	4	3
109	R:R:F102	R:R:Y131	7.22	Yes	Yes	1	4	5
110	R:R:D103	R:R:E106	6.5	Yes	Yes	12	3	4
111	R:R:A136	R:R:D103	4.63	No	Yes	0	2	3
112	R:R:D103	R:R:K141	4.15	Yes	No	12	3	3
113	R:R:C134	R:R:E106	3.04	No	Yes	0	9	4
114	R:R:E106	R:R:K141	4.05	Yes	No	12	4	3
115	R:R:E106	R:R:K366	9.45	Yes	No	0	4	3
116	R:R:V108	R:R:Y131	10.09	No	Yes	0	7	5
117	R:R:K110	R:R:W118	8.12	No	Yes	1	8	9
118	R:R:K110	R:R:S129	9.18	No	Yes	1	8	7
119	R:R:E114	R:R:Y111	26.93	No	No	0	2	4
120	R:R:F119	R:R:Y111	4.13	No	No	0	4	4
121	R:R:C112	R:R:W118	9.14	No	Yes	1	9	9
122	R:R:D113	R:R:G116	6.71	No	No	0	5	9
123	R:R:K120	R:R:R126	4.95	No	No	0	1	4
124	R:R:H121	R:R:P122	10.68	Yes	No	0	4	5
125	R:R:E123	R:R:H121	11.08	No	Yes	0	4	4
126	R:R:H121	R:R:W128	7.41	Yes	Yes	0	4	5
127	R:R:N124	R:R:R126	8.44	No	No	0	5	4
128	R:R:N130	R:R:W128	5.65	No	Yes	7	8	5
129	H:H:?1	R:R:W128	3.07	Yes	Yes	7	0	5
130	R:R:S129	R:R:Y131	3.82	Yes	Yes	1	7	5
131	R:R:N130	R:R:T132	5.85	No	No	7	8	6
132	H:H:?1	R:R:N130	28.34	Yes	No	7	0	8
133	H:H:?1	R:R:T132	3.97	Yes	No	7	0	6
134	H:H:?1	R:R:M133	3.81	Yes	No	0	0	5
135	R:R:A136	R:R:F137	4.16	No	Yes	0	2	1
136	R:R:P139	R:R:T138	5.25	No	No	0	3	2
137	R:R:K141	R:R:T138	9.01	No	No	0	3	2
138	R:R:L142	R:R:Y146	10.55	No	No	0	2	2
139	R:R:K370	R:R:N144	13.99	No	No	4	4	4
140	R:R:N144	R:R:Y374	8.14	No	Yes	4	4	6
141	R:R:V147	R:R:Y374	8.83	No	Yes	0	4	6
142	R:R:D373	R:R:L148	5.43	No	Yes	0	5	5
143	R:R:L148	R:R:Y374	3.52	Yes	Yes	4	5	6
144	R:R:H377	R:R:L148	11.57	No	Yes	4	7	5
145	R:R:I153	R:R:Y149	8.46	No	No	0	7	5
146	R:R:L202	R:R:Y149	5.86	No	No	0	7	5
147	R:R:F382	R:R:L151	3.65	Yes	No	0	7	5
148	R:R:A152	R:R:H381	7.32	No	Yes	0	7	9
149	R:R:F382	R:R:G155	9.03	Yes	No	0	7	8
150	R:R:H156	R:R:S195	11.16	Yes	No	0	7	7
151	R:R:H156	R:R:I198	17.23	Yes	Yes	0	7	7
152	R:R:H156	R:R:H381	9.55	Yes	Yes	0	7	9
153	R:R:F385	R:R:L158	3.65	Yes	No	0	5	4
154	R:R:S159	R:R:S195	4.89	No	No	0	9	7
155	R:R:G384	R:R:S159	3.71	No	No	0	9	9
156	R:R:I160	R:R:S195	3.1	No	No	0	5	7
157	R:R:F161	R:R:I165	5.02	No	No	0	4	5
158	R:R:F385	R:R:T162	6.49	Yes	No	0	5	6
159	R:R:F188	R:R:L163	6.09	No	No	0	8	8
160	R:R:I192	R:R:L163	4.28	Yes	No	0	7	8
161	R:R:A388	R:R:L163	3.15	No	No	0	8	8
162	R:R:A388	R:R:S166	3.42	No	No	0	8	9
163	R:R:C392	R:R:S166	6.89	No	No	0	9	9
164	R:R:F393	R:R:S166	5.28	No	No	0	8	9
165	R:R:F173	R:R:I169	3.77	Yes	No	0	7	8
166	R:R:F170	R:R:V181	5.24	Yes	No	0	8	9
167	R:R:F170	R:R:K185	4.96	Yes	No	0	8	6
168	R:R:F170	R:R:F188	6.43	Yes	No	0	8	8
169	R:R:C392	R:R:F170	5.59	No	Yes	0	9	8
170	R:R:K185	R:R:V171	3.04	No	No	0	6	4
171	R:R:F172	R:R:F173	6.43	No	Yes	0	2	7
172	R:R:F173	R:R:T401	3.89	Yes	Yes	0	7	7
173	R:R:F173	R:R:V402	3.93	Yes	No	0	7	5
174	R:R:F173	R:R:Q405	7.03	Yes	No	0	7	4
175	R:R:S175	R:R:T401	3.2	No	Yes	0	8	7
176	R:R:L176	R:R:T401	4.42	No	Yes	0	9	7
177	R:R:C178	R:R:V181	3.42	No	No	0	8	9
178	R:R:Q179	R:R:Y243	13.53	No	Yes	6	7	8
179	R:R:Q179	R:R:Q257	7.68	No	Yes	6	7	5
180	R:R:L259	R:R:Q179	9.32	No	No	0	5	7
181	R:R:R180	R:R:Y243	4.12	No	Yes	0	9	8
182	R:R:N395	R:R:R180	3.62	No	No	0	9	9
183	R:R:L183	R:R:W236	4.56	No	Yes	0	8	9
184	R:R:L183	R:R:Y243	7.03	No	Yes	0	8	8
185	R:R:E240	R:R:H184	12.31	No	No	0	9	9
186	R:R:H184	R:R:Y391	7.62	No	Yes	0	9	8
187	R:R:N186	R:R:W236	9.04	No	Yes	0	9	9
188	R:R:N186	R:R:Y263	5.81	No	No	0	9	5
189	R:R:M187	R:R:Y191	7.18	No	Yes	0	8	8
190	R:R:E240	R:R:M187	4.06	No	No	0	9	8
191	R:R:F188	R:R:V387	3.93	No	No	0	8	9
192	R:R:L189	R:R:W267	3.42	No	Yes	0	3	9
193	R:R:C232	R:R:T190	5.07	No	Yes	2	8	9
194	R:R:N233	R:R:T190	4.39	Yes	Yes	2	9	9
195	R:R:T190	R:R:W236	3.64	Yes	Yes	2	9	9
196	R:R:T190	R:R:W267	6.06	Yes	Yes	2	9	9
197	R:R:N233	R:R:Y191	16.28	Yes	Yes	2	9	8
198	R:R:M237	R:R:Y191	3.59	Yes	Yes	2	9	8
199	R:R:Q383	R:R:Y191	11.27	Yes	Yes	2	9	8
200	R:R:G384	R:R:Y191	4.35	No	Yes	0	9	8
201	R:R:V387	R:R:Y191	3.79	No	Yes	0	9	8
202	R:R:L193	R:R:M229	7.07	No	No	0	6	4
203	R:R:I198	R:R:N194	5.66	Yes	No	0	7	8
204	R:R:N194	R:R:N233	4.09	No	Yes	0	8	9
205	R:R:H226	R:R:I197	3.98	No	No	0	6	5
206	R:R:H226	R:R:I198	3.98	No	Yes	0	6	7
207	R:R:E204	R:R:I200	8.2	No	No	0	4	6
208	R:R:H201	R:R:V205	9.69	Yes	No	0	6	7
209	R:R:H201	R:R:H223	3.58	Yes	No	0	6	5
210	R:R:H201	R:R:L291	6.43	Yes	No	0	6	6
211	R:R:P207	R:R:V206	3.53	No	No	0	3	3
212	R:R:L211	R:R:N208	4.12	No	No	0	1	3
213	R:R:L211	R:R:P216	3.28	No	Yes	13	1	4
214	R:R:C219	R:R:L211	3.17	No	No	13	9	1
215	R:R:P216	R:R:R214	10.09	Yes	No	0	4	4
216	R:R:D215	R:R:N288	12.12	No	No	0	6	4
217	R:R:P216	R:R:S218	3.56	Yes	No	0	4	3
218	R:R:C219	R:R:P216	3.77	No	Yes	13	9	4
219	R:R:C219	R:R:C289	7.28	No	No	0	9	9
220	R:R:K220	R:R:N286	6.99	No	No	5	7	7
221	R:R:K220	R:R:W290	5.8	No	Yes	5	7	9
222	R:R:H223	R:R:Q227	8.65	No	Yes	0	5	7
223	R:R:H223	R:R:W290	5.29	No	Yes	0	5	9
224	R:R:F224	R:R:T274	6.49	No	No	0	5	6
225	R:R:M230	R:R:Q227	5.44	No	Yes	3	6	7
226	R:R:H302	R:R:Q227	4.95	Yes	Yes	3	6	7
227	R:R:L271	R:R:Y228	5.86	No	No	0	4	8
228	R:R:T274	R:R:Y228	3.75	No	No	0	6	8
229	R:R:M230	R:R:Y234	5.99	No	Yes	0	6	7
230	R:R:H302	R:R:M230	5.25	Yes	No	3	6	6
231	R:R:C232	R:R:W267	5.22	No	Yes	2	8	9
232	R:R:M237	R:R:N233	4.21	Yes	Yes	2	9	9
233	R:R:M237	R:R:Y234	4.79	Yes	Yes	0	9	7
234	R:R:V305	R:R:Y234	5.05	No	Yes	0	7	7
235	R:R:F356	R:R:Y234	13.41	Yes	Yes	0	7	7
236	R:R:F235	R:R:L265	3.65	Yes	No	8	5	7
237	R:R:F235	R:R:F269	8.57	Yes	No	8	5	3
238	R:R:F235	R:R:P270	4.33	Yes	Yes	8	5	9
239	R:R:A308	R:R:F235	4.16	No	Yes	0	7	5
240	R:R:C239	R:R:W236	5.22	No	Yes	0	7	9
241	R:R:G266	R:R:W236	8.44	No	Yes	0	9	9
242	R:R:W236	R:R:W267	14.06	Yes	Yes	2	9	9
243	R:R:M237	R:R:Q383	5.44	Yes	Yes	2	9	9
244	R:R:I242	R:R:L238	7.14	No	No	0	7	8
245	R:R:A308	R:R:L238	3.15	No	No	0	7	8
246	R:R:C239	R:R:L265	4.76	No	No	0	7	7
247	R:R:E240	R:R:L351	7.95	No	No	0	9	9
248	R:R:G241	R:R:N312	3.39	No	No	0	8	9
249	R:R:I242	R:R:Y262	4.84	No	Yes	0	7	7
250	R:R:L247	R:R:Y243	3.52	No	Yes	6	8	8
251	R:R:Q257	R:R:Y243	7.89	Yes	Yes	6	5	8
252	R:R:Y243	R:R:Y262	7.94	Yes	Yes	6	8	7
253	R:R:I319	R:R:L244	4.28	No	No	0	9	9
254	R:R:H245	R:R:V249	15.22	Yes	No	14	8	6
255	R:R:F315	R:R:H245	18.1	No	Yes	0	8	8
256	R:R:H245	R:R:N318	10.2	Yes	No	14	8	8
257	R:R:H245	R:R:I319	3.98	Yes	No	0	8	9
258	R:R:Q257	R:R:T246	9.92	Yes	No	0	5	7
259	R:R:L247	R:R:Q257	3.99	No	Yes	6	8	5
260	R:R:N318	R:R:V249	7.39	No	No	14	8	6
261	R:R:A251	R:R:T254	3.36	No	No	0	6	6
262	R:R:Q257	R:R:Y262	3.38	Yes	Yes	6	5	7
263	R:R:R258	R:R:W261	13	No	No	0	5	2
264	R:R:L259	R:R:Y262	4.69	No	Yes	0	5	7
265	R:R:L259	R:R:Y263	3.52	No	No	0	5	5
266	R:R:F269	R:R:L265	4.87	No	No	8	3	7
267	R:R:F269	R:R:P270	4.33	No	Yes	8	3	9
268	R:R:P273	R:R:V272	5.3	No	No	0	6	4
269	R:R:I301	R:R:T274	4.56	No	No	0	7	6
270	R:R:H277	R:R:R281	13.54	Yes	Yes	0	7	7
271	R:R:H277	R:R:L298	5.14	Yes	No	0	7	6
272	R:R:H277	R:R:I301	9.28	Yes	No	0	7	7
273	R:R:T280	R:R:Y284	3.75	No	No	0	4	2
274	R:R:F285	R:R:R281	7.48	No	Yes	5	6	7
275	R:R:R281	R:R:W290	12	Yes	Yes	5	7	9
276	R:R:R281	R:R:T295	3.88	Yes	No	5	7	4
277	R:R:V283	R:R:Y284	10.09	No	No	0	3	2
278	R:R:F285	R:R:S292	5.28	No	No	0	6	4
279	R:R:F285	R:R:T295	18.16	No	No	5	6	4
280	R:R:N286	R:R:W290	3.39	No	Yes	5	7	9
281	R:R:D287	R:R:S292	7.36	No	No	0	3	4
282	R:R:C289	R:R:L291	3.17	No	No	0	9	6
283	R:R:L297	R:R:T295	5.9	No	No	0	4	4
284	R:R:H296	R:R:Y299	3.27	No	No	0	2	7
285	R:R:G303	R:R:P304	4.06	No	No	0	4	9
286	R:R:F356	R:R:L309	3.65	Yes	No	0	7	7
287	R:R:F314	R:R:V310	3.93	No	No	0	5	4
288	R:R:L352	R:R:N312	13.73	No	No	0	9	9
289	R:R:F313	R:R:L317	9.74	Yes	No	0	6	5
290	R:R:F313	R:R:I354	5.02	Yes	Yes	0	6	6
291	R:R:F313	R:R:V357	6.55	Yes	No	0	6	7
292	R:R:I354	R:R:L316	5.71	Yes	No	0	6	9
293	R:R:N318	R:R:R321	8.44	No	No	0	8	8
294	R:R:T345	R:R:V320	3.17	No	No	0	9	7
295	R:R:R321	R:R:V322	3.92	No	No	0	8	8
296	R:R:R328	R:R:V324	6.54	No	Yes	0	6	5
297	R:R:K340	R:R:M327	5.76	No	No	0	8	7
298	R:R:E332	R:R:H336	13.54	No	No	0	5	6
299	R:R:E334	R:R:M337	5.41	No	No	0	6	7
300	R:R:E334	R:R:Y338	14.59	No	No	0	6	7
301	R:R:H336	R:R:K340	6.55	No	No	0	6	8
302	R:R:I347	R:R:I390	5.89	No	No	0	8	8
303	R:R:P350	R:R:V349	3.53	No	No	0	9	8
304	R:R:I354	R:R:V349	10.75	Yes	No	0	6	8
305	R:R:L351	R:R:Y391	12.89	No	Yes	0	9	8
306	R:R:I354	R:R:L352	4.28	Yes	No	0	6	9
307	R:R:G353	R:R:Q355	4.93	No	Yes	0	9	8
308	R:R:F356	R:R:Q355	11.71	Yes	Yes	2	7	8
309	R:R:L379	R:R:Q355	3.99	No	Yes	0	5	8
310	R:R:Q355	R:R:Q383	7.68	Yes	Yes	2	8	9
311	R:R:F356	R:R:I380	6.28	Yes	No	0	7	6
312	R:R:F356	R:R:Q383	3.51	Yes	Yes	2	7	9
313	R:R:F359	R:R:V358	9.18	No	No	0	6	5
314	R:R:F359	R:R:W361	4.01	No	No	0	6	4
315	R:R:F359	R:R:M376	3.73	No	Yes	0	6	7
316	R:R:P360	R:R:W361	5.4	No	No	0	5	4
317	R:R:P363	R:R:W361	5.4	Yes	No	0	7	4
318	R:R:R362	R:R:Y372	4.12	No	No	0	4	7
319	R:R:D373	R:R:R362	9.53	No	No	0	5	4
320	R:R:L368	R:R:P363	4.93	No	Yes	0	3	7
321	R:R:P363	R:R:Y372	6.95	Yes	No	0	7	7
322	R:R:L368	R:R:N365	12.36	No	No	0	3	4
323	R:R:K370	R:R:Y374	7.17	No	Yes	4	4	6
324	R:R:M376	R:R:Y372	10.78	Yes	No	0	7	7
325	R:R:I380	R:R:M376	5.83	No	Yes	0	6	7
326	R:R:H377	R:R:H381	9.55	No	Yes	0	7	9
327	R:R:F385	R:R:F386	5.36	Yes	No	0	5	5
328	R:R:F385	R:R:T389	7.78	Yes	No	0	5	5
329	R:R:V387	R:R:Y391	3.79	No	Yes	0	9	8
330	R:R:F393	R:R:T389	3.89	No	No	0	8	5
331	R:R:I390	R:R:Y391	7.25	No	Yes	0	8	8
332	R:R:N395	R:R:V398	5.91	No	No	0	9	9
333	R:R:Q405	R:R:Q408	6.4	No	No	0	4	7
334	L:L:T6	R:R:M306	3.01	Yes	No	0	0	4
335	R:R:F119	R:R:W128	3.01	No	Yes	0	4	5
336	R:R:K120	R:R:T127	3	No	No	0	1	4
337	R:R:K185	R:R:T182	3	No	No	0	6	5
338	L:L:N21	L:L:S20	2.98	No	No	0	0	0
339	R:R:Y149	R:R:Y150	2.98	No	No	0	5	4
340	R:R:L176	R:R:V398	2.98	No	No	0	9	9
341	R:R:L316	R:R:V320	2.98	No	No	0	9	7
342	R:R:I276	R:R:I300	2.94	No	No	0	5	8
343	R:R:I192	R:R:M196	2.92	Yes	No	0	7	4
344	R:R:I197	R:R:M229	2.92	No	No	0	5	4
345	L:L:G24	R:R:Y41	2.9	No	No	0	0	3
346	R:R:M48	R:R:M49	2.89	No	No	0	6	4
347	R:R:F386	R:R:P350	2.89	No	No	0	5	9
348	R:R:E294	R:R:S292	2.87	No	No	0	3	4
349	R:R:I192	R:R:L167	2.85	Yes	No	0	7	6
350	R:R:I198	R:R:L202	2.85	Yes	No	0	7	7
351	R:R:K343	R:R:L339	2.82	No	No	0	8	6
352	L:L:G33	R:R:W128	2.81	No	Yes	0	0	5
353	L:L:K1	L:L:N3	2.8	No	No	0	0	0
354	R:R:P38	R:R:Y41	2.78	No	No	0	5	3
355	L:L:A8	L:L:R11	2.77	No	No	0	0	0
356	L:L:L12	L:L:L16	2.77	No	No	0	0	0
357	L:L:F15	R:R:A145	2.77	No	No	0	0	4
358	R:R:D50	R:R:K54	2.77	No	No	0	2	4
359	R:R:A278	R:R:F224	2.77	No	No	0	6	5
360	R:R:L244	R:R:L348	2.77	No	No	0	9	9
361	R:R:H245	R:R:V250	2.77	Yes	No	0	8	5
362	R:R:L316	R:R:L348	2.77	No	No	0	9	9
363	R:R:L348	R:R:L352	2.77	No	No	0	9	9
364	R:R:M49	R:R:Q52	2.72	No	Yes	0	4	6
365	R:R:E114	R:R:K115	2.7	No	No	0	2	5
366	R:R:A51	R:R:Y98	2.67	No	Yes	0	8	4
367	R:R:H156	R:R:I199	2.65	Yes	No	0	7	7
368	R:R:E397	R:R:L176	2.65	No	No	0	9	9
369	R:R:H277	R:R:I300	2.65	Yes	No	0	7	8
370	L:L:R11	R:R:V293	2.62	No	Yes	0	0	6
371	R:R:H201	R:R:L222	2.57	Yes	No	0	6	6
372	R:R:M48	R:R:R45	2.48	No	No	0	6	7
373	R:R:M337	R:R:R328	2.48	No	No	0	7	6
374	R:R:S91	R:R:W82	2.47	No	Yes	0	5	9
375	R:R:F382	R:R:L158	2.44	Yes	No	0	7	4
376	L:L:N22	R:R:F137	2.42	No	Yes	0	0	1
377	R:R:E210	R:R:R214	2.33	No	No	0	3	4
378	R:R:D50	R:R:Y53	2.3	No	No	0	2	1
379	R:R:D97	R:R:Y98	2.3	No	Yes	0	2	4
380	R:R:L264	R:R:W261	2.28	No	No	0	3	2
381	R:R:Q52	R:R:Y53	2.25	Yes	No	0	6	1
382	R:R:F224	R:R:F225	2.14	No	No	0	5	5
383	R:R:F313	R:R:F314	2.14	Yes	No	0	6	5
384	R:R:G268	R:R:P270	2.03	No	Yes	0	6	9
385	R:R:G369	R:R:P363	2.03	No	Yes	0	4	7
386	R:R:F409	R:R:W406	2	No	No	0	3	6
387	R:R:C178	R:R:G177	1.96	No	No	0	8	7
388	L:L:P28	L:L:P29	1.95	No	No	0	0	0
389	R:R:A87	R:R:P70	1.87	No	No	0	4	1
390	R:R:A231	R:R:P270	1.87	No	Yes	0	5	9
391	R:R:G44	R:R:V43	1.84	No	No	0	4	2
392	R:R:G116	R:R:V117	1.84	No	No	0	9	5
393	R:R:G168	R:R:V171	1.84	No	No	0	1	4
394	R:R:G88	R:R:T85	1.82	No	Yes	0	8	7
395	R:R:C289	R:R:V212	1.71	No	No	0	9	3
396	R:R:G268	R:R:L264	1.71	No	No	0	6	3
397	L:L:A13	R:R:V206	1.7	No	No	0	0	3
398	L:L:G33	L:L:N35	1.7	No	No	0	0	0
399	R:R:A251	R:R:V250	1.7	No	No	0	6	5
400	R:R:A341	R:R:V324	1.7	No	Yes	0	9	5
401	R:R:I301	R:R:P273	1.69	No	No	0	7	6
402	R:R:D103	R:R:P104	1.61	Yes	No	0	3	3
403	R:R:V320	R:R:V324	1.6	No	Yes	0	7	5
404	R:R:A344	R:R:L323	1.58	No	No	0	9	9
405	R:R:T400	R:R:T401	1.57	No	Yes	0	4	7
406	R:R:I199	R:R:S157	1.55	No	No	0	7	7
407	R:R:A87	R:R:D113	1.54	No	No	0	4	5
408	R:R:I153	R:R:V203	1.54	No	No	0	7	3
409	R:R:I160	R:R:V164	1.54	No	No	0	5	4
410	R:R:I192	R:R:V164	1.54	Yes	No	0	7	4
411	R:R:I199	R:R:V203	1.54	No	No	0	7	3
412	R:R:I221	R:R:V217	1.54	No	No	0	4	3
413	R:R:I248	R:R:V249	1.54	No	No	0	7	6
414	R:R:I248	R:R:V322	1.54	No	No	0	7	8
415	R:R:K366	R:R:S105	1.53	No	No	0	3	1
416	R:R:K47	R:R:V43	1.52	No	No	0	4	2
417	R:R:K143	R:R:V147	1.52	No	No	0	1	4
418	R:R:I276	R:R:T275	1.52	No	No	0	5	3
419	R:R:I279	R:R:T280	1.52	No	No	0	3	4
420	R:R:K326	R:R:V322	1.52	No	No	0	9	8
421	R:R:M327	R:R:V324	1.52	No	Yes	0	7	5
422	R:R:L151	R:R:S378	1.5	No	No	0	5	5
423	R:R:L238	R:R:V311	1.49	No	No	0	8	6
424	R:R:I165	R:R:I169	1.47	No	No	0	5	8
425	R:R:L297	R:R:T280	1.47	No	No	0	4	4
426	R:R:A333	R:R:H336	1.46	No	No	0	5	6
427	R:R:I371	R:R:M367	1.46	No	No	0	5	4
428	R:R:N396	R:R:T400	1.46	No	No	0	6	4
429	R:R:D83	R:R:T85	1.45	No	Yes	0	5	7
430	R:R:F235	R:R:P304	1.44	Yes	No	0	5	9
431	R:R:I200	R:R:L222	1.43	No	No	0	6	6
432	R:R:E140	R:R:T138	1.41	No	No	0	2	2
433	R:R:L323	R:R:M327	1.41	No	No	0	9	7
434	R:R:M367	R:R:N365	1.4	No	No	0	4	4
435	R:R:D50	R:R:K46	1.38	No	No	0	2	4
436	R:R:N396	R:R:Q399	1.32	No	No	0	6	7
437	R:R:F39	R:R:V42	1.31	No	No	0	4	1
438	R:R:R45	R:R:V42	1.31	No	No	0	7	1
439	R:R:F382	R:R:V154	1.31	Yes	No	0	7	6
440	R:R:A407	R:R:W406	1.3	No	No	0	4	6
441	L:L:T4	R:R:Y299	1.25	No	No	0	0	7
442	R:R:Q408	R:R:R404	1.17	No	No	0	7	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:T6	4.87	4	0	0
2	L:L:C7	5.295	4	3	0
3	L:L:S19	5.32	4	9	0
4	L:L:Y37	8.73	4	1	0
5	R:R:Q52	7.355	4	0	6
6	R:R:R74	4.8575	4	10	4
7	R:R:D77	5.576	5	1	9
8	R:R:W79	9.886	5	1	6
9	R:R:W82	8.12714	7	1	9
10	R:R:T85	2.5375	4	0	7
11	R:R:Y98	4.536	5	0	4
12	R:R:F99	7.14	4	1	5
13	R:R:D101	7.16	4	1	4
14	R:R:F102	6.512	5	1	4
15	R:R:D103	4.2225	4	12	3
16	R:R:E106	5.76	4	12	4
17	R:R:W118	7.952	5	1	9
18	R:R:H121	10.43	4	0	4
19	R:R:W128	4.27167	6	7	5
20	R:R:S129	5.9	4	1	7
21	R:R:Y131	6.59	8	1	5
22	R:R:F137	6.062	5	9	1
23	R:R:L148	6.1675	4	4	5
24	R:R:H156	10.1475	4	0	7
25	R:R:F170	5.555	4	0	8
26	R:R:F173	5.01	5	0	7
27	R:R:T190	4.79	4	2	9
28	R:R:Y191	7.74333	6	2	8
29	R:R:I192	2.8975	4	0	7
30	R:R:I198	6.552	5	0	7
31	R:R:H201	5.5675	4	0	6
32	R:R:P216	5.175	4	13	4
33	R:R:Q227	7	4	3	7
34	R:R:N233	7.2425	4	2	9
35	R:R:Y234	6.598	5	0	7
36	R:R:F235	4.43	5	8	5
37	R:R:W236	7.49333	6	2	9
38	R:R:M237	4.5075	4	2	9
39	R:R:Y243	7.33833	6	6	8
40	R:R:H245	10.054	5	14	8
41	R:R:Q257	6.572	5	6	5
42	R:R:Y262	5.2125	4	6	7
43	R:R:W267	7.19	4	2	9
44	R:R:P270	3.14	4	8	9
45	R:R:H277	7.6525	4	0	7
46	R:R:R281	9.225	4	5	7
47	R:R:W290	6.62	4	5	9
48	R:R:V293	4.2125	4	3	6
49	R:R:H302	6.42	4	3	6
50	R:R:F313	5.8625	4	0	6
51	R:R:V324	2.84	4	0	5
52	R:R:I354	6.44	4	0	6
53	R:R:Q355	7.0775	4	2	8
54	R:R:F356	7.712	5	2	7
55	R:R:P363	4.8275	4	0	7
56	R:R:Y374	6.915	4	4	6
57	R:R:M376	5.89	4	0	7
58	R:R:H381	8.3175	4	0	9
59	R:R:F382	4.1075	4	0	7
60	R:R:Q383	6.975	4	2	9
61	R:R:F385	5.82	4	0	5
62	R:R:Y391	7.8875	4	0	8
63	R:R:T401	3.27	4	0	7
64	H:H:?1	9.7975	4	7	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:C2	R:R:L298	14.4479	3.17	No	No	0	0	6
2	R:R:H277	R:R:L298	13.6701	5.14	Yes	No	0	7	6
3	L:L:C2	L:L:C7	10.3069	7.28	No	Yes	3	0	0
4	R:R:R281	R:R:W290	10.0806	12	Yes	Yes	5	7	9
5	R:R:H223	R:R:W290	11.5485	5.29	No	Yes	0	5	9
6	R:R:H223	R:R:Q227	25.6613	8.65	No	Yes	0	5	7
7	L:L:T6	R:R:H302	40.0027	9.58	Yes	Yes	0	0	6
8	R:R:M230	R:R:Y234	54.8178	5.99	No	Yes	0	6	7
9	R:R:M230	R:R:Q227	15.9602	5.44	No	Yes	3	6	7
10	L:L:Q10	R:R:H226	15.2634	6.18	No	No	0	0	6
11	R:R:H226	R:R:I198	15.8937	3.98	No	Yes	0	6	7
12	R:R:H156	R:R:H381	17.1408	9.55	Yes	Yes	0	7	9
13	R:R:H377	R:R:H381	19.37	9.55	No	Yes	0	7	9
14	L:L:L12	R:R:H377	15.3777	5.14	No	No	4	0	7
15	L:L:N14	R:R:V293	90.8737	7.39	No	Yes	0	0	6
16	L:L:N14	L:L:R18	90.2712	8.44	No	No	0	0	0
17	L:L:F15	R:R:F137	15.8493	7.5	No	Yes	9	0	1
18	L:L:R18	R:R:F137	89.6986	9.62	No	Yes	0	0	1
19	L:L:F15	R:R:A145	17.7866	2.77	No	No	0	0	4
20	L:L:L16	R:R:A145	17.9031	3.15	No	No	0	0	4
21	R:R:H201	R:R:H223	15.0848	3.58	Yes	No	0	6	5
22	R:R:H201	R:R:L291	11.7505	6.43	Yes	No	0	6	6
23	R:R:C289	R:R:L291	11.077	3.17	No	No	0	9	6
24	R:R:M48	R:R:Y98	29.9909	4.79	No	Yes	0	6	4
25	R:R:P96	R:R:Y98	35.7197	6.95	No	Yes	0	9	4
26	R:R:P96	R:R:Y131	36.6562	6.95	No	Yes	0	9	5
27	R:R:V108	R:R:Y131	73.451	10.09	No	Yes	0	7	5
28	R:R:C95	R:R:V108	91.1078	3.42	No	No	0	9	7
29	R:R:C134	R:R:C95	91.859	7.28	No	No	0	9	9
30	R:R:C134	R:R:E106	92.608	3.04	No	Yes	0	9	4
31	R:R:D103	R:R:E106	94.3777	6.5	Yes	Yes	12	3	4
32	R:R:A136	R:R:D103	99.2732	4.63	No	Yes	0	2	3
33	R:R:A136	R:R:F137	100	4.16	No	Yes	0	2	1
34	L:L:V32	R:R:Y131	29.9909	3.79	No	Yes	0	0	5
35	L:L:V32	R:R:W128	25.0444	3.68	No	Yes	0	0	5
36	R:R:V108	R:R:W82	19.5697	4.9	No	Yes	0	7	9
37	R:R:M48	R:R:M49	22.1883	2.89	No	No	0	6	4
38	R:R:M49	R:R:Q52	21.203	2.72	No	Yes	0	4	6
39	R:R:W118	R:R:W82	15.8715	4.69	Yes	Yes	1	9	9
40	R:R:F119	R:R:W128	10.207	3.01	No	Yes	0	4	5
41	R:R:M237	R:R:Y234	91.4152	4.79	Yes	Yes	0	9	7
42	R:R:M237	R:R:Y191	65.2401	3.59	Yes	Yes	2	9	8
43	R:R:V387	R:R:Y191	81.1992	3.79	No	Yes	0	9	8
44	R:R:F188	R:R:V387	79.1987	3.93	No	No	0	8	9
45	R:R:F188	R:R:L163	37.8634	6.09	No	No	0	8	8
46	R:R:A388	R:R:L163	49.767	3.15	No	No	0	8	8
47	R:R:A388	R:R:S166	49.1556	3.42	No	No	0	8	9
48	R:R:F393	R:R:S166	84.6767	5.28	No	No	0	8	9
49	R:R:F393	R:R:T389	83.5427	3.89	No	No	0	8	5
50	R:R:F385	R:R:T389	82.4065	7.78	Yes	No	0	5	5
51	R:R:F170	R:R:F188	41.4473	6.43	Yes	No	0	8	8
52	R:R:C392	R:R:F170	37.2343	5.59	No	Yes	0	9	8
53	R:R:C392	R:R:S166	36.725	6.89	No	No	0	9	9
54	R:R:H156	R:R:S195	15.583	11.16	Yes	No	0	7	7
55	R:R:I160	R:R:S195	14.773	3.1	No	No	0	5	7
56	R:R:M237	R:R:N233	27.2314	4.21	Yes	Yes	2	9	9
57	R:R:N233	R:R:T190	52.8749	4.39	Yes	Yes	2	9	9
58	R:R:T190	R:R:W236	49.4108	3.64	Yes	Yes	2	9	9
59	R:R:L183	R:R:W236	26.7021	4.56	No	Yes	0	8	9
60	R:R:L183	R:R:Y243	25.8089	7.03	No	Yes	0	8	8
61	R:R:R180	R:R:Y243	18.0673	4.12	No	Yes	0	9	8
62	R:R:N395	R:R:R180	17.1353	3.62	No	No	0	9	9
63	R:R:N395	R:R:V398	16.221	5.91	No	No	0	9	9
64	R:R:L176	R:R:V398	15.2845	2.98	No	No	0	9	9
65	R:R:L176	R:R:T401	13.4049	4.42	No	Yes	0	9	7
66	R:R:I160	R:R:V164	14.4434	1.54	No	No	0	5	4
67	R:R:I192	R:R:V164	14.2171	1.54	Yes	No	0	7	4
68	R:R:I192	R:R:L163	14.2237	4.28	Yes	No	0	7	8
69	R:R:I198	R:R:N194	17.3539	5.66	Yes	No	0	7	8
70	R:R:H277	R:R:I301	10.5044	9.28	Yes	No	0	7	7
71	R:R:C239	R:R:W236	19.5042	5.22	No	Yes	0	7	9
72	R:R:C239	R:R:L265	18.5899	4.76	No	No	0	7	7
73	R:R:F235	R:R:L265	11.1324	3.65	Yes	No	8	5	7
74	R:R:F385	R:R:F386	73.2369	5.36	Yes	No	0	5	5
75	R:R:F386	R:R:P350	72.0807	2.89	No	No	0	5	9
76	R:R:P350	R:R:V349	70.9223	3.53	No	No	0	9	8
77	R:R:I354	R:R:V349	69.7617	10.75	Yes	No	0	6	8
78	R:R:I354	R:R:L352	23.4222	4.28	Yes	No	0	6	9
79	R:R:I354	R:R:L316	39.4346	5.71	Yes	No	0	6	9
80	R:R:L316	R:R:L348	20.0424	2.77	No	No	0	9	9
81	R:R:L244	R:R:L348	37.2498	2.77	No	No	0	9	9
82	R:R:I319	R:R:L244	34.8109	4.28	No	No	0	9	9
83	R:R:L348	R:R:L352	19.7805	2.77	No	No	0	9	9
84	R:R:H245	R:R:I319	32.3388	3.98	Yes	No	0	8	9
85	R:R:L316	R:R:V320	18.8263	2.98	No	No	0	9	7
86	R:R:V320	R:R:V324	16.3408	1.6	No	Yes	0	7	5
87	L:L:C7	R:R:H302	82.2045	5.9	Yes	Yes	3	0	6
88	L:L:T6	R:R:Y234	40.2523	3.75	Yes	Yes	0	0	7
89	R:R:H302	R:R:M230	38.8354	5.25	Yes	No	3	6	6
90	L:L:C7	L:L:Q10	16.7425	4.58	Yes	No	0	0	0
91	L:L:L12	L:L:L16	18.1572	2.77	No	No	0	0	0
92	R:R:N194	R:R:N233	17.396	4.09	No	Yes	0	8	9
93	L:L:C7	R:R:V293	87.7413	3.42	Yes	Yes	3	0	6
94	R:R:N233	R:R:Y191	15.9236	16.28	Yes	Yes	2	9	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:K1	R:R:E294	5.4	0	No	No	0	3	0	1
L:L:C2	R:R:V293	3.42	3	No	Yes	0	6	0	1
L:L:C2	R:R:L298	3.17	3	No	No	0	6	0	1
L:L:A5	R:R:M376	3.22	0	No	Yes	0	7	0	1
L:L:T6	R:R:Y234	3.75	0	Yes	Yes	0	7	0	1
L:L:T6	R:R:H302	9.58	0	Yes	Yes	0	6	0	1
L:L:C7	R:R:V293	3.42	3	Yes	Yes	0	6	0	1
L:L:C7	R:R:H302	5.9	3	Yes	Yes	0	6	0	1
L:L:T9	R:R:I198	3.04	0	No	Yes	0	7	0	1
L:L:T9	R:R:H381	6.85	0	No	Yes	0	9	0	1
L:L:Q10	R:R:H226	6.18	0	No	No	0	6	0	1
L:L:Q10	R:R:Q227	8.96	0	No	Yes	0	7	0	1
L:L:L12	R:R:L148	4.15	4	No	Yes	0	5	0	1
L:L:L12	R:R:H377	5.14	4	No	No	0	7	0	1
L:L:N14	R:R:V293	7.39	0	No	Yes	0	6	0	1
L:L:F15	R:R:F137	7.5	9	No	Yes	0	1	0	1
L:L:L16	R:R:A145	3.15	0	No	No	0	4	0	1
L:L:V17	R:R:V206	4.81	0	No	No	0	3	0	1
L:L:V17	R:R:V212	3.21	0	No	No	0	3	0	1
L:L:R18	R:R:F137	9.62	0	No	Yes	0	1	0	1
L:L:S19	R:R:F137	6.61	9	Yes	Yes	0	1	0	1
L:L:S19	R:R:L142	4.5	9	Yes	No	0	2	0	1
L:L:S20	R:R:Y146	5.09	0	No	No	0	2	0	1
L:L:N21	R:R:G209	6.79	0	No	No	0	3	0	1
L:L:L23	R:R:V212	4.47	0	No	No	0	3	0	1
L:L:L23	R:R:N288	4.12	0	No	No	0	4	0	1
L:L:L27	R:R:R213	8.5	0	No	No	0	2	0	1
L:L:T30	R:R:F99	11.67	1	No	Yes	0	5	0	1
L:L:T30	R:R:D101	10.12	1	No	Yes	0	4	0	1
L:L:T30	R:R:F102	6.49	1	No	Yes	0	4	0	1
L:L:V32	R:R:W128	3.68	0	No	Yes	0	5	0	1
L:L:V32	R:R:Y131	3.79	0	No	Yes	0	5	0	1
L:L:V32	R:R:T132	3.17	0	No	No	0	6	0	1
L:L:S34	R:R:H121	12.55	0	No	Yes	0	4	0	1
L:L:S34	R:R:N124	8.94	0	No	No	0	5	0	1
L:L:Y37	R:R:G78	8.69	1	Yes	No	0	5	0	1
L:L:Y37	R:R:W79	12.54	1	Yes	Yes	0	6	0	1
L:L:?38	R:R:W79	11.28	1	No	Yes	0	6	0	1
R:R:R45	R:R:Y41	4.12	0	No	No	7	3	2	1
R:R:D77	R:R:G78	3.35	1	Yes	No	9	5	2	1
R:R:D77	R:R:L80	5.43	1	Yes	No	9	5	2	2
R:R:D77	R:R:S129	4.42	1	Yes	Yes	9	7	2	2
R:R:D77	R:R:Y131	5.75	1	Yes	Yes	9	5	2	1
R:R:F99	R:R:W79	9.02	1	Yes	Yes	5	6	1	1
R:R:F102	R:R:W79	5.01	1	Yes	Yes	4	6	1	1
R:R:W79	R:R:Y131	11.58	1	Yes	Yes	6	5	1	1
R:R:L80	R:R:Y131	3.52	1	No	Yes	5	5	2	1
R:R:P96	R:R:Y131	6.95	0	No	Yes	9	5	2	1
R:R:D101	R:R:F99	3.58	1	Yes	Yes	4	5	1	1
R:R:F102	R:R:F99	4.29	1	Yes	Yes	4	5	1	1
R:R:D101	R:R:F102	9.55	1	Yes	Yes	4	4	1	1
R:R:D101	R:R:N135	5.39	1	Yes	No	4	3	1	2
R:R:F102	R:R:Y131	7.22	1	Yes	Yes	4	5	1	1
R:R:V108	R:R:Y131	10.09	0	No	Yes	7	5	2	1
R:R:H121	R:R:P122	10.68	0	Yes	No	4	5	1	2
R:R:E123	R:R:H121	11.08	0	No	Yes	4	4	2	1
R:R:H121	R:R:W128	7.41	0	Yes	Yes	4	5	1	1
R:R:N124	R:R:R126	8.44	0	No	No	5	4	1	2
R:R:N130	R:R:W128	5.65	7	No	Yes	8	5	2	1
H:H:?1	R:R:W128	3.07	7	Yes	Yes	0	5	2	1
R:R:S129	R:R:Y131	3.82	1	Yes	Yes	7	5	2	1
R:R:N130	R:R:T132	5.85	7	No	No	8	6	2	1
H:H:?1	R:R:N130	28.34	7	Yes	No	0	8	2	2
H:H:?1	R:R:T132	3.97	7	Yes	No	0	6	2	1
R:R:A136	R:R:F137	4.16	0	No	Yes	2	1	2	1
R:R:L142	R:R:Y146	10.55	0	No	No	2	2	1	1
R:R:D373	R:R:L148	5.43	0	No	Yes	5	5	2	1
R:R:L148	R:R:Y374	3.52	4	Yes	Yes	5	6	1	2
R:R:H377	R:R:L148	11.57	4	No	Yes	7	5	1	1
R:R:A152	R:R:H381	7.32	0	No	Yes	7	9	2	1
R:R:H156	R:R:I198	17.23	0	Yes	Yes	7	7	2	1
R:R:H156	R:R:H381	9.55	0	Yes	Yes	7	9	2	1
R:R:I198	R:R:N194	5.66	0	Yes	No	7	8	1	2
R:R:H226	R:R:I197	3.98	0	No	No	6	5	1	2
R:R:H226	R:R:I198	3.98	0	No	Yes	6	7	1	1
R:R:P207	R:R:V206	3.53	0	No	No	3	3	2	1
R:R:D215	R:R:N288	12.12	0	No	No	6	4	2	1
R:R:H223	R:R:Q227	8.65	0	No	Yes	5	7	2	1
R:R:M230	R:R:Q227	5.44	3	No	Yes	6	7	2	1
R:R:H302	R:R:Q227	4.95	3	Yes	Yes	6	7	1	1
R:R:M230	R:R:Y234	5.99	3	No	Yes	6	7	2	1
R:R:H302	R:R:M230	5.25	3	Yes	No	6	6	1	2
R:R:M237	R:R:Y234	4.79	2	Yes	Yes	9	7	2	1
R:R:V305	R:R:Y234	5.05	0	No	Yes	7	7	2	1
R:R:F356	R:R:Y234	13.41	2	Yes	Yes	7	7	2	1
R:R:H277	R:R:L298	5.14	0	Yes	No	7	6	2	1
R:R:H296	R:R:Y299	3.27	0	No	No	2	7	2	1
R:R:F356	R:R:I380	6.28	2	Yes	No	7	6	2	2
R:R:F359	R:R:M376	3.73	0	No	Yes	6	7	2	1
R:R:M376	R:R:Y372	10.78	0	Yes	No	7	7	1	2
R:R:I380	R:R:M376	5.83	0	No	Yes	6	7	2	1
R:R:H377	R:R:H381	9.55	4	No	Yes	7	9	1	1
L:L:T6	R:R:M306	3.01	0	Yes	No	0	4	0	1
R:R:F119	R:R:W128	3.01	0	No	Yes	4	5	2	1
L:L:G24	R:R:Y41	2.9	0	No	No	0	3	0	1
R:R:E294	R:R:S292	2.87	0	No	No	3	4	1	2
R:R:I198	R:R:L202	2.85	0	Yes	No	7	7	1	2
L:L:G33	R:R:W128	2.81	0	No	Yes	0	5	0	1
R:R:P38	R:R:Y41	2.78	0	No	No	5	3	2	1
L:L:F15	R:R:A145	2.77	9	No	No	0	4	0	1
L:L:R11	R:R:V293	2.62	0	No	Yes	0	6	0	1
L:L:N22	R:R:F137	2.42	0	No	Yes	0	1	0	1
R:R:C289	R:R:V212	1.71	0	No	No	9	3	2	1
L:L:A13	R:R:V206	1.7	0	No	No	0	3	0	1
L:L:T4	R:R:Y299	1.25	0	No	No	0	7	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7TYI_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.04
Number of Linked Nodes	385
Number of Links	442
Number of Hubs	64
Number of Links mediated by Hubs	236
Number of Communities	14
Number of Nodes involved in Communities	76
Number of Links involved in Communities	99

Path Summary
Number Of Nodes in MetaPath	95
Number Of Links MetaPath	94
Number of Shortest Paths	177416
Length Of Smallest Path	3
Average Path Length	23.3741
Length of Longest Path	49
Minimum Path Strength	1.31
Average Path Strength	5.51166
Maximum Path Strength	17.25
Minimum Path Correlation	0.7
Average Path Correlation	0.95482
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	2.32558
Average % Of Corr. Nodes	45.6103
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	41.71
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• amide binding • amyloid-beta binding • binding • peptide binding • calcitonin family receptor activity • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • calcitonin receptor activity • amylin receptor activity • calcitonin gene-related peptide receptor activity • calcitonin binding • calcitonin family binding • peptide hormone binding • hormone binding • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • cellular response to stimulus • positive regulation of cell communication • regulation of cellular process • positive regulation of signal transduction • response to stimulus • signaling • positive regulation of biological process • regulation of signal transduction • intracellular signal transduction • cell communication • positive regulation of response to stimulus
Gene Ontology	Biological Process	• positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • cellular response to stimulus • positive regulation of cell communication • regulation of cellular process • positive regulation of signal transduction • response to stimulus • signaling • positive regulation of biological process • regulation of signal transduction • intracellular signal transduction • cell communication • positive regulation of response to stimulus • regulation of intracellular signal transduction • intracellular signaling cassette • regulation of calcium-mediated signaling • positive regulation of calcium-mediated signaling • signal transduction • positive regulation of cellular process • regulation of biological process • regulation of signaling • positive regulation of intracellular signal transduction • regulation of response to stimulus • calcium-mediated signaling • regulation of cell communication • cellular process • positive regulation of signaling • catabolic process • negative regulation of biological process • RNA metabolic process • macromolecule catabolic process • regulation of primary metabolic process • nucleobase-containing compound metabolic process • post-transcriptional regulation of gene expression • regulation of RNA metabolic process • regulation of mRNA catabolic process • negative regulation of cellular process • regulation of nucleobase-containing compound metabolic process • RNA catabolic process • negative regulation of macromolecule metabolic process • regulation of biosynthetic process • mRNA catabolic process • negative regulation of metabolic process • primary metabolic process • regulation of macromolecule metabolic process • regulation of catabolic process • gene expression • mRNA metabolic process • macromolecule biosynthetic process • nucleic acid metabolic process • nucleobase-containing compound catabolic process • regulation of mRNA stability • regulation of gene expression • negative regulation of gene expression • biosynthetic process • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • regulation of RNA stability • nucleic acid catabolic process • metabolic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • regulation of mRNA metabolic process • regulation of metabolic process • positive regulation of ERK1 and ERK2 cascade • positive regulation of MAPK cascade • regulation of MAPK cascade • MAPK cascade • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of macromolecule biosynthetic process • positive regulation of metabolic process • positive regulation of gene expression • positive regulation of biosynthetic process • positive regulation of macromolecule metabolic process • amylin receptor 1 signaling pathway • amylin receptor signaling pathway • calcitonin family receptor signaling pathway • G protein-coupled receptor signaling pathway • regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • phosphatidylinositol 3-kinase/protein kinase B signal transduction • response to corticosteroid • response to lipid • response to hormone • response to steroid hormone • response to chemical • response to endogenous stimulus • response to glucocorticoid • adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • response to amyloid-beta • cell surface receptor signaling pathway • calcitonin gene-related peptide receptor signaling pathway • multicellular organismal process • ossification • amylin receptor 2 signaling pathway • developmental process • myeloid leukocyte differentiation • cellular developmental process • hemopoiesis • cell development • myeloid cell differentiation • cell differentiation • osteoclast differentiation • anatomical structure development • leukocyte differentiation • positive regulation of cAMP/PKA signal transduction • cAMP/PKA signal transduction • regulation of cAMP/PKA signal transduction • regulation of multicellular organismal process • negative regulation of multicellular organismal process • regulation of ossification • negative regulation of ossification • amylin receptor 3 signaling pathway • membrane-bounded organelle • cell projection • cellular anatomical structure • organelle • cilium • plasma membrane bounded cell projection • cell periphery • plasma membrane • membrane • protein-containing complex • amylin receptor complex • plasma membrane protein complex • amylin receptor complex 3 • membrane protein complex
Gene Ontology	Cellular Component	• membrane-bounded organelle • cell projection • cellular anatomical structure • organelle • cilium • plasma membrane bounded cell projection • cell periphery • plasma membrane • membrane • protein-containing complex • amylin receptor complex • plasma membrane protein complex • amylin receptor complex 3 • membrane protein complex • receptor complex • plasma membrane signaling receptor complex • G protein-coupled receptor complex • calcitonin family receptor complex • amylin receptor complex 2 • amylin receptor complex 1 • axon • neuron projection • acrosomal vesicle • intracellular anatomical structure • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle • secretory granule • secretory vesicle • cytoplasm • vesicle • protein binding • binding • signaling receptor binding • molecular function activator activity • molecular function regulator activity • signaling receptor regulator activity • receptor ligand activity • signaling receptor activator activity • hormone activity • lipid binding • identical protein binding • cellular response to stimulus • positive regulation of cell communication • regulation of cellular process • positive regulation of signal transduction • response to stimulus • signaling • positive regulation of biological process • regulation of signal transduction • intracellular signal transduction • cell communication • positive regulation of response to stimulus • regulation of intracellular signal transduction • intracellular signaling cassette • regulation of calcium-mediated signaling • positive regulation of calcium-mediated signaling • signal transduction • positive regulation of cellular process • regulation of biological process • regulation of signaling • biological regulation • positive regulation of intracellular signal transduction • regulation of response to stimulus • calcium-mediated signaling • regulation of cell communication • cellular process • positive regulation of signaling • behavior • multicellular organismal process • eating behavior • feeding behavior • amylin receptor 1 signaling pathway • amylin receptor signaling pathway • calcitonin family receptor signaling pathway • G protein-coupled receptor signaling pathway • myeloid leukocyte differentiation • regulation of leukocyte differentiation • cellular developmental process • regulation of developmental process • negative regulation of biological process • cell development • regulation of cell differentiation • regulation of cell development • regulation of osteoclast differentiation • multicellular organism development • cell differentiation • osteoclast differentiation • anatomical structure development • negative regulation of cellular process • regulation of immune system process • regulation of multicellular organismal process • negative regulation of cell differentiation • negative regulation of hemopoiesis • developmental process • regulation of multicellular organismal development • negative regulation of leukocyte differentiation • hemopoiesis • regulation of myeloid cell differentiation • negative regulation of developmental process • regulation of myeloid leukocyte differentiation • negative regulation of myeloid cell differentiation • negative regulation of osteoclast differentiation • negative regulation of myeloid leukocyte differentiation • negative regulation of cell development • myeloid cell differentiation • negative regulation of immune system process • immune system process • regulation of hemopoiesis • negative regulation of multicellular organismal process • leukocyte differentiation • monosaccharide metabolic process • carbohydrate metabolic process • hexose metabolic process • small molecule metabolic process • metabolic process • primary metabolic process • glucose metabolic process • negative regulation of tissue remodeling • homeostatic process • negative regulation of bone remodeling • regulation of bone remodeling • tissue homeostasis • regulation of tissue remodeling • regulation of bone resorption • bone resorption • negative regulation of bone resorption • multicellular organismal-level homeostasis • tissue remodeling • bone remodeling • anatomical structure homeostasis • amylin receptor 2 signaling pathway • system process • sensory perception • nervous system process • sensory perception of pain • positive regulation of cAMP/PKA signal transduction • cAMP/PKA signal transduction • regulation of cAMP/PKA signal transduction • amylin receptor 3 signaling pathway • somatodendritic compartment • cell body • neuronal cell body • extracellular region • extracellular space • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • extrinsic component of plasma membrane • catalytic complex • cytoplasmic side of membrane • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular membrane-bounded organelle • synapse • cell junction • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception of taste • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • organelle membrane • cytosol • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • G protein-coupled receptor binding • dopamine receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • sensory perception of smell • response to peptide hormone • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • skeletal system development • bone development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • adaptive thermogenesis • positive regulation of metabolic process • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • regulation of metabolic process • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • localization • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • regulation of protein transport • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • inflammatory response to antigenic stimulus • regulation of response to stress • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • trans-Golgi network
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	NH2
PDB Residues	L:L:?38
Environment Details	Open EMBL-EBI Page
Code	NH2
Name	AMINO GROUP
Synonyms
Identifier
Formula	H2 N
Molecular Weight	16.023
SMILES
PubChem	123329
Formal Charge	0
Total Atoms	3
Total Chiral Atoms	0
Total Bonds	2
Total Aromatic Bonds	0


Code	NAG
PDB Residues	H:H:?1 H:H:?2
Environment Details	Open EMBL-EBI Page
Code	NAG
Name	N-Acetylglucosamine
Synonyms	N-Acetylglucosamine
Identifier
Formula	C8 H15 N O6
Molecular Weight	221.208
SMILES
PubChem	24139
Formal Charge	0
Total Atoms	30
Total Chiral Atoms	5
Total Bonds	30
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P30988
Sequence	>7TYI_nogp_Chain_R P F L Y V V G R K K M M D A Q Y K C Y D R M Q Q L P A P Y C N R T W D G W L C W D D T P A G V L S Y Q F C P D Y F P D F D P S E K V T K Y C D E K G V W F K H P E N N R T W S N Y T M C N A F T P E K L K N A Y V L Y Y L A I V G H S L S I F T L V I S L G I F V F F R S L G C Q R V T L H K N M F L T Y I L N S M I I I I H L V E V V P N G E L V R R D P V S C K I L H F F H Q Y M M A C N Y F W M L C E G I Y L H T L I V V A V F T E K Q R L R W Y Y L L G W G F P L V P T T I H A I T R A V Y F N D N C W L S V E T H L L Y I I H G P V M A A L V V N F F F L L N I V R V L V T K M R E T H E A E S H M Y L K A V K A T M I L V P L L G I Q F V V F P W R P S N K M L G K I Y D Y V M H S L I H F Q G F F V A T I Y C F C N N E V Q T T V K R Q W A Q F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7X5H	A	Amine	5-Hydroxytryptamine	5-HT_5A	Homo sapiens	5-CT	-	Gi1/β1/γ2	3.1	2022-09-14	doi.org/10.1038/s41421-022-00412-3
	7X5H (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_5A	Homo sapiens	5-CT	-		3.1	2022-09-14	doi.org/10.1038/s41421-022-00412-3
	7UM5	A	Amine	5-Hydroxytryptamine	5-HT_5A	Homo sapiens	5-CT	-	chim(NtGi1-Go)/β1/γ2	2.73	2022-07-20	doi.org/10.1038/s41594-022-00796-6
	7UM5 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_5A	Homo sapiens	5-CT	-		2.73	2022-07-20	doi.org/10.1038/s41594-022-00796-6
	7XTC	A	Amine	5-Hydroxytryptamine	5-HT₇	Homo sapiens	5-CT	-	Gs/β1/γ2	3.2	2022-07-27	doi.org/10.1016/j.molcel.2022.05.031
	7XTC (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT₇	Homo sapiens	5-CT	-		3.2	2022-07-27	doi.org/10.1016/j.molcel.2022.05.031
	6E67	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	-	Gs(CT)	3.7	2019-06-05	doi.org/10.1016/j.cell.2019.04.021
	6NIY	B1	Peptide	Calcitonin	CT	Homo sapiens	Adrenomedullin	-	Gs/β1/γ2	3.34	2019-01-23	doi.org/10.1021/acsptsci.8b00056
	6NIY (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	Adrenomedullin	-		3.34	2019-01-23	doi.org/10.1021/acsptsci.8b00056
	5UZ7	B1	Peptide	Calcitonin	CT	Homo sapiens	-	-	Gs/β1/γ2	4.1	2017-05-03	doi.org/10.1038/nature22327
	5UZ7 (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	-	-		4.1	2017-05-03	doi.org/10.1038/nature22327
	8F0J	B1	Peptide	Calcitonin	CT	Homo sapiens	Pramlintide Analogue San45	-	Gs/β1/γ2	2	2023-08-02	doi.org/10.1038/s41589-023-01393-4
	8F0J (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	Pramlintide Analogue San45	-		2	2023-08-02	doi.org/10.1038/s41589-023-01393-4
	7TYL	B1	Peptide	Calcitonin	CT	Homo sapiens	Amylin	-	Gs/β1/γ2	3.3	2022-03-23	doi.org/10.1126/science.abm9609
	7TYL (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	Amylin	-		3.3	2022-03-23	doi.org/10.1126/science.abm9609
	7TYO	B1	Peptide	Calcitonin	CT	Homo sapiens	Calcitonin	-	Gs/β1/γ2	2.7	2022-03-23	doi.org/10.1126/science.abm9609
	7TYO (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	Calcitonin	-		2.7	2022-03-23	doi.org/10.1126/science.abm9609
	7TYI	B1	Peptide	Calcitonin	CT	Homo sapiens	Amylin	-	Gs/β1/γ2	3.3	2022-03-30	doi.org/10.1126/science.abm9609
	7TYI (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	Amylin	-		3.3	2022-03-30	doi.org/10.1126/science.abm9609
	7TYN	B1	Peptide	Calcitonin	CT	Homo sapiens	Calcitonin-1	-	Gs/β1/γ2	2.6	2022-03-30	doi.org/10.1126/science.abm9609
	7TYN (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	Calcitonin-1	-		2.6	2022-03-30	doi.org/10.1126/science.abm9609
	9BUB	B1	Peptide	Calcitonin	CT	Homo sapiens	Cagrilintide	-	Gs/β1/γ2	2.3	2025-04-23	doi.org/10.1038/s41467-025-58680-y
	9BUB (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	Cagrilintide	-		2.3	2025-04-23	doi.org/10.1038/s41467-025-58680-y
	9BLB	B1	Peptide	Calcitonin	CT	Homo sapiens	Cagrilintide backbone (non-acylated)	-	Gs/β1/γ2	3.2	2025-04-16	To be published
	9BLB (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	Cagrilintide backbone (non-acylated)	-		3.2	2025-04-16	To be published
	9BLC	B1	Peptide	Calcitonin	CT	Homo sapiens	Cagrilintide backbone (non-acylated)	-	Gs/β1/γ2	3.3	2025-04-16	To be published
	9BLC (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	Cagrilintide backbone (non-acylated)	-		3.3	2025-04-16	To be published
	9BUE	B1	Peptide	Calcitonin	CT	Homo sapiens	Cagrilintide	-	Gs/β1/γ2	3.6	2025-04-16	To be published
	9BUE (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	Cagrilintide	-		3.6	2025-04-16	To be published
	9BUC	B1	Peptide	Calcitonin	CT	Homo sapiens	Cagrilintide	-	Gs/β1/γ2	3.4	2025-04-23	To be published
	9BUC (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	Cagrilintide	-		3.4	2025-04-23	To be published
	9BUD	B1	Peptide	Calcitonin	CT	Homo sapiens	Cagrilintide	-	Gs/β1/γ2	2.5	2025-04-23	To be published
	9BUD (No Gprot)	B1	Peptide	Calcitonin	CT	Homo sapiens	Cagrilintide	-		2.5	2025-04-23	To be published
	9AUC	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Calcitonin gene-related peptide-1	-	Gs/β1/γ2; RAMP1	2.4	2024-04-24	doi.org/10.1021/acs.biochem.4c00114
	9AUC (No Gprot)	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Calcitonin gene-related peptide-1	-		2.4	2024-04-24	doi.org/10.1021/acs.biochem.4c00114
	7TYF	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Amylin	-	Gs/β1/γ2; RAMP1	2.2	2022-03-23	doi.org/10.1126/science.abm9609
	7TYF (No Gprot)	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Amylin	-		2.2	2022-03-23	doi.org/10.1126/science.abm9609
	7TYW	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Calcitonin-1	-	Gs/β1/γ2; RAMP1	3	2022-03-23	doi.org/10.1126/science.abm9609
	7TYW (No Gprot)	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Calcitonin-1	-		3	2022-03-23	doi.org/10.1126/science.abm9609
	9BLW	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Cagrilintide backbone (non-acylated)	-	Gs/β1/γ2; RAMP1	3.2	2025-04-16	To be published
	9BLW (No Gprot)	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Cagrilintide backbone (non-acylated)	-		3.2	2025-04-16	To be published
	9BP3	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Cagrilintide	-	Gs/β1/γ2; RAMP1	2.2	2025-04-23	To be published
	9BP3 (No Gprot)	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Cagrilintide	-		2.2	2025-04-23	To be published
	7TYH	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Calcitonin-1	-	Gs/β1/γ2; RAMP2	3.3	2022-03-23	doi.org/10.1126/science.abm9609
	7TYH (No Gprot)	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Calcitonin-1	-		3.3	2022-03-23	doi.org/10.1126/science.abm9609
	7TYY	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Calcitonin-1	-	Gs/β1/γ2; RAMP2	3	2022-03-23	doi.org/10.1126/science.abm9609
	7TYY (No Gprot)	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Calcitonin-1	-		3	2022-03-23	doi.org/10.1126/science.abm9609
	7TYX	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Amylin	-	Gs/β1/γ2; RAMP2	2.55	2022-03-30	doi.org/10.1126/science.abm9609
	7TYX (No Gprot)	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Amylin	-		2.55	2022-03-30	doi.org/10.1126/science.abm9609
	9BQ3	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Cagrilintide	-	Gs/β1/γ2; RAMP2	2.8	2025-04-23	To be published
	9BQ3 (No Gprot)	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Cagrilintide	-		2.8	2025-04-23	To be published
	8F0K	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Pramlintide Analogue San385	-	Gs/β1/γ2; RAMP3	1.9	2023-08-02	doi.org/10.1038/s41589-023-01393-4
	8F0K (No Gprot)	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Pramlintide Analogue San385	-		1.9	2023-08-02	doi.org/10.1038/s41589-023-01393-4
	8F2A	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Pramlintide Analogue San385	-	Gs/β1/γ2; RAMP3	2.2	2023-08-02	doi.org/10.1038/s41589-023-01393-4
	8F2A (No Gprot)	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Pramlintide Analogue San385	-		2.2	2023-08-02	doi.org/10.1038/s41589-023-01393-4
	8F2B	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Pramlintide Analogue San45	-	Gs/β1/γ2; RAMP3	2	2023-08-02	doi.org/10.1038/s41589-023-01393-4
	8F2B (No Gprot)	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Pramlintide Analogue San45	-		2	2023-08-02	doi.org/10.1038/s41589-023-01393-4
	7TZF	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Amylin	-	Gs/β1/γ2; RAMP3	2.4	2022-03-23	doi.org/10.1126/science.abm9609
	7TZF (No Gprot)	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Amylin	-		2.4	2022-03-23	doi.org/10.1126/science.abm9609
	9BTW	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Cagrilintide	-	Gs/β1/γ2; RAMP3	3	2025-04-16	To be published
	9BTW (No Gprot)	B1	Peptide	Calcitonin	CT (AMY3)	Homo sapiens	Cagrilintide	-		3	2025-04-16	To be published
	6E3Y	B1	Peptide	Calcitonin	CT Like	Homo sapiens	Calcitonin gene-related peptide-1	-	Gs/β1/γ2; RAMP1	3.3	2018-09-19	doi.org/10.1038/s41586-018-0535-y
	6E3Y (No Gprot)	B1	Peptide	Calcitonin	CT Like	Homo sapiens	Calcitonin gene-related peptide-1	-		3.3	2018-09-19	doi.org/10.1038/s41586-018-0535-y
	7KNT	B1	Peptide	Calcitonin	CT Like	Homo sapiens	-	-	RAMP1	3.15	2021-02-24	doi.org/10.1126/science.abf7258
	7KNU	B1	Peptide	Calcitonin	CT Like	Homo sapiens	Calcitonin gene-related peptide-1	-	RAMP1	3.49	2021-02-24	doi.org/10.1126/science.abf7258
	6UUN	B1	Peptide	Calcitonin	CT Like (AM1)	Homo sapiens	Adrenomedullin	-	Gs/β1/γ2; RAMP2	3	2020-03-25	doi.org/10.1021/acsptsci.9b00080
	6UUN (No Gprot)	B1	Peptide	Calcitonin	CT Like (AM1)	Homo sapiens	Adrenomedullin	-		3	2020-03-25	doi.org/10.1021/acsptsci.9b00080
	6UUS	B1	Peptide	Calcitonin	CT Like (AM2)	Homo sapiens	Adrenomedullin	-	Gs/β1/γ2; RAMP3	2.4	2020-04-01	doi.org/10.1021/acsptsci.9b00080
	6UUS (No Gprot)	B1	Peptide	Calcitonin	CT Like (AM2)	Homo sapiens	Adrenomedullin	-		2.4	2020-04-01	doi.org/10.1021/acsptsci.9b00080
	6UVA	B1	Peptide	Calcitonin	CT Like (AM2)	Homo sapiens	Adrenomedullin-2	-	Gs/β1/γ2; RAMP3	2.3	2020-04-01	doi.org/10.1021/acsptsci.9b00080
	6UVA (No Gprot)	B1	Peptide	Calcitonin	CT Like (AM2)	Homo sapiens	Adrenomedullin-2	-		2.3	2020-04-01	doi.org/10.1021/acsptsci.9b00080
	6PH7	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	Nerol	Gt(CT)	2.9	2020-07-01	To be published
	6PGS	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	Geraniol	Gt(CT)	2.9	2020-07-01	To be published
	6PEL	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	Citronellol	Gt(CT)	3.19	2020-06-24	To be published
	4J4Q	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl β-D-Glucopyranoside	-	Gt(CT)	2.65	2013-10-30	doi.org/10.1002/anie.201302374
	4X1H	A	Sensory	Opsins	Rhodopsin	Bos taurus	Nonyl-β-D-Glucopyranoside	-	Gt(CT)	2.29	2015-11-04	doi.org/10.1016/j.str.2015.09.015
	4BEY	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	Gt(CT)	2.9	2013-05-08	doi.org/10.1038/embor.2013.44
	3DQB	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	Gt(CT)	3.2	2008-09-23	doi.org/10.1038/nature07330
	3PQR	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gt(CT)	2.85	2011-03-09	doi.org/10.1038/nature09789
	2X72	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gt(CT)	3	2011-03-16	doi.org/10.1038/nature09795
	5WKT	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl-β-D-Glucopyranoside	-	Gt(CT)	3.2	2017-12-13	doi.org/10.1038/nprot.2017.135
	4A4M	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gt(CT)	3.3	2012-01-25	doi.org/10.1073/pnas.1114089108
	5EN0	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gt(CT)	2.81	2016-08-10	doi.org/10.15252/embr.201642671
	6NWE	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl-β-D-Glucopyranoside	-	Gt(CT)	2.71	2020-02-12	To be published
	6TP4	A	Peptide	Orexin	OX₁	Homo sapiens	ACT-462206	-	-	3.01	2020-01-01	doi.org/10.1021/acs.jmedchem.9b01787

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7TYI_nogp.zip

You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.

You can also read or download a guide explaining the meaning of all files and numerical data.