Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:?17 1.9975403
2A:A:?34 6.0765105
3A:A:?37 8.958336103
4A:A:H41 5.9825406
5A:A:L46 5.1325499
6A:A:?47 3.9625409
7A:A:S51 5.175459
8A:A:?53 6.03759
9A:A:I56 4.89458
10A:A:M60 4.8225459
11A:A:?206 7.77578
12A:A:V214 4.3525455
13A:A:F219 6.795658
14A:A:M221 5.71558
15A:A:?225 5.8225479
16A:A:Q227 8.0575479
17A:A:?233 4.7925409
18A:A:F238 9.188599
19A:A:I244 4.6725498
20A:A:?253 11.78754179
21A:A:F273 5.09639
22A:A:W277 9.97667636
23A:A:W281 8.9275425
24A:A:L282 5.2975499
25A:A:F290 5.434509
26A:A:L291 4.86254199
27A:A:N292 5.742559
28A:A:?293 5.5125409
29A:A:?305 6.25403
30A:A:?311 10.24336175
31A:A:F315 8.402506
32A:A:?318 8.112507
33A:A:?339 8.48333603
34A:A:F340 7.235406
35A:A:R342 7.27405
36A:A:F345 5.9408
37A:A:?358 9.34857734
38A:A:?359 15.69436
39A:A:?360 13.1271738
40A:A:H362 9.265439
41A:A:F363 6.75254195
42A:A:T364 8.0925459
43A:A:?365 9.928557
44A:A:F376 6.36833659
45A:A:?379 5.1275409
46A:A:R380 6.1225457
47A:A:R385 8.3525436
48A:A:L388 5.652538
49A:A:?391 6.78571734
50A:A:L394 4.21167637
51B:B:L7 1.85408
52B:B:N16 4.6325401
53B:B:?25 5.135403
54B:B:M45 4.9725404
55B:B:R48 4.4754117
56B:B:L51 6.064239
57B:B:H54 8.4925409
58B:B:?59 9.1575428
59B:B:W63 7.38667607
60B:B:V71 7.11408
61B:B:D76 8.0425109
62B:B:?78 7.4425108
63B:B:I80 6.145408
64B:B:W82 9.5054239
65B:B:?85 10.42836114
66B:B:?89 7.3975409
67B:B:W99 10.152599
68B:B:T102 12.8025448
69B:B:?103 5.61333648
70B:B:?105 10.0033606
71B:B:N110 10.9775444
72B:B:?111 10.4243744
73B:B:?114 8.09833648
74B:B:?115 9.0975409
75B:B:?116 7.3775409
76B:B:N119 7.8025479
77B:B:?121 5.11648
78B:B:I123 4.1575406
79B:B:?124 7.385846
80B:B:L139 5.085409
81B:B:?144 9.89578
82B:B:?145 10.6871778
83B:B:?148 14.146546
84B:B:?149 13.1233648
85B:B:R150 8.455446
86B:B:N155 3.6875403
87B:B:S161 9.0125479
88B:B:?162 7.875679
89B:B:D163 8.146579
90B:B:W169 6.82667678
91B:B:F180 7.346547
92B:B:H183 6.67429749
93B:B:?185 7.28405
94B:B:D186 8.0725479
95B:B:L190 5.7445
96B:B:F199 6.045449
97B:B:?202 4.2475406
98B:B:D205 7.97449
99B:B:W211 9.56429748
100B:B:?218 11.2775405
101B:B:Q220 6.985427
102B:B:F222 6.73428
103B:B:H225 8.76143729
104B:B:I232 6.488528
105B:B:?233 6.34833623
106B:B:F234 6.0875405
107B:B:F235 7.08626
108B:B:P236 6.1527
109B:B:N237 10.5225425
110B:B:?238 5.6675427
111B:B:F241 6.06125826
112B:B:T243 5.935428
113B:B:?244 4.7475405
114B:B:D247 10.274529
115B:B:T249 6.5325426
116B:B:?250 9.376528
117B:B:R251 10.9229728
118B:B:F253 8.114526
119B:B:D254 5.415409
120B:B:R256 9.045409
121B:B:D258 8.6275427
122B:B:?264 11.83725
123B:B:?271 8.55167625
124B:B:?272 9.81524
125B:B:I273 7.206526
126B:B:T274 5.825428
127B:B:F278 5.42143727
128B:B:?282 4.108529
129B:B:R283 7.114509
130B:B:?289 9.5041027
131B:B:D290 7.964526
132B:B:N293 8.01425
133B:B:N295 6.675626
134B:B:W297 7.962528
135B:B:?301 6.8925405
136B:B:R304 6.205425
137B:B:V307 4.82423
138B:B:?310 5.415425
139B:B:H311 7.36429729
140B:B:R314 10.574528
141B:B:S316 7.4575429
142B:B:?317 9.542527
143B:B:L318 4.71406
144B:B:?319 6.0725405
145B:B:T321 8.50254207
146B:B:D323 7.244207
147B:B:?330 7.61425
148B:B:W332 10.03629
149B:B:?337 4.952526
150B:B:W339 9.60833629
151B:B:N340 4.5654119
152G:G:L15 3.52254262
153G:G:?40 11.1186726
154G:G:?41 8.955407
155G:G:D48 7.612529
156G:G:L51 5.7275426
157G:G:N59 4.6525119
158G:G:F61 4.5225118
159R:R:?58 7.656505
160R:R:L59 4.9325407
161R:R:Q82 8.37406
162R:R:N92 4.9445136
163R:R:F94 6.27409
164R:R:E102 8.46517
165R:R:N107 7.085407
166R:R:?109 5.7925416
167R:R:L111 7.7475417
168R:R:?113 7.92511
169R:R:?117 4.315133
170R:R:I120 4.7825135
171R:R:L125 4.61833619
172R:R:?126 7.412515
173R:R:?127 9.34516
174R:R:?131 13.545417
175R:R:N132 8.17518
176R:R:T133 7.1775408
177R:R:?134 4.5075415
178R:R:I135 5.656517
179R:R:F138 8.65405
180R:R:F151 6.035415
181R:R:E154 8.4925417
182R:R:?156 13.5533617
183R:R:D157 9.8375416
184R:R:N158 9.355419
185R:R:F169 4.632516
186R:R:V177 5.5375413
187R:R:L179 4.9775418
188R:R:?180 4.63415
189R:R:L181 4.5625408
190R:R:?182 11.1071716
191R:R:?183 7.835417
192R:R:N184 9.06667619
193R:R:F186 8.49333608
194R:R:F194 6.82419
195R:R:L202 6.78407
196R:R:?216 5.524273
197R:R:?223 6.4925407
198R:R:L227 5.64254288
199R:R:?240 12.8075402
200R:R:?241 9.575407
201R:R:L259 5.5625406
202R:R:?275 17.2745148
203R:R:H278 9.27754149
204R:R:?280 13.0925489
205R:R:F282 5.318588
206R:R:R283 6.5875483
207R:R:?331 6.1565301
208R:R:E354 6.388507
209R:R:?359 11.9585316
210R:R:L362 7.844318
211R:R:?389 9.458336253
212R:R:?399 5.7456158
213R:R:N400 9.12754157
214R:R:S402 7.30754158
215R:R:D405 6.9525409
216R:R:?407 6.53167667
217R:R:?409 5.28857769
218R:R:?411 8.6867
219R:R:?426 10.7067689
220R:R:?427 11.875687
221R:R:?438 9.66468
222R:R:?439 8.99714769
223R:R:?443 9.108569
224R:R:L452 6.25407
225R:R:?455 8.846508
226R:R:R464 7.1275438
227R:R:W465 6.755435
228R:R:I472 6.064555
229R:R:?490 7.45408
230R:R:W491 5.9025405
231R:R:I497 5.14254185
232R:R:V505 5.78754185
233R:R:?508 11.7312868
234R:R:?514 11.198569
235R:R:F515 6.87125869
236R:R:?527 7.117789187
237R:R:F539 5.74408
238R:R:?543 6.754537
239R:R:?545 9.20143736
240R:R:?546 9.236371139
241R:R:?548 5.192534
242R:R:I549 5.59333639
243R:R:?550 6.47333639
244R:R:N555 4.6475437
245R:R:?569 4.264537
246R:R:M571 6.3075438
247R:R:L574 5.5025439
248R:R:?581 5.7075409
249R:R:?612 10.14567
250R:R:S616 5.1975409
251R:R:?617 5.038509
252R:R:N619 9.5554329
253R:R:?623 7.8275439
254R:R:F630 7.87408
255L:L:?31 12.076510
256L:L:?34 8.385410
257L:L:N39 4.614330
258L:L:Q51 5.23754220
259L:L:?52 6.5865220
260L:L:M53 7.4754220
261L:L:?55 13.9817610
262L:L:?61 7.91571710
263L:L:?83 11.1783610
264L:L:?84 12.3075410
265L:L:?89 8.21400
266L:L:?99 6.9975400
267L:L:?108 10.954510
268L:L:T110 6.412510
269L:L:?111 17.778510
270L:L:?112 13.4057710
271L:L:?113 10.7157710
272L:L:H114 12.0333610
273L:L:?115 7.98410
274N:N:R26 11.765410
275N:N:R28 5.842510
276N:N:?29 8.89333610
277N:N:R30 8.035400
278N:N:?42 8.584160
279N:N:?43 11.6025160
280N:N:?46 9.575400
281N:N:?54 6.884510
282N:N:?57 14.2944910
283N:N:?58 12.1383610
284N:N:Q74 11.8525410
285N:N:V76 7.304510
286N:N:?77 10.7133610
287N:N:N78 6.334510
288N:N:?79 6.44875810
289N:N:?92 11.2265160
290N:N:?102 7.4458120
291N:N:V104 5.2465120
292N:N:?108 9.858510
293N:N:Q109 8.005410
294N:N:?110 14.2175400
295N:N:?113 6.28429710
296N:N:D119 6.61400
297N:N:?120 10.894510
298N:N:?122 10.1975400
299N:N:?124 7.7400
300N:N:?130 11.15754340
301W:W:?801 7.261360
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:?59 B:B:Q75 46.799411.65YesNo089
2B:B:Q75 B:B:W99 82.425.48NoYes099
3A:A:F238 B:B:W99 99.560513.03YesYes999
4A:A:F238 A:A:L44 99.92415.83YesNo999
5A:A:L44 A:A:L46 99.68886.92NoYes999
6A:A:?47 A:A:L46 1003.62YesYes099
7A:A:?47 A:A:S51 14.9685.24YesYes099
8A:A:?47 A:A:R231 85.40994.24YesNo099
9B:B:?115 B:B:?116 10.228510.53YesYes099
10B:B:R314 B:B:T274 35.02949.06YesYes288
11B:B:R314 B:B:W332 71.264224.99YesYes289
12A:A:D272 A:A:R231 85.389313.1NoNo099
13A:A:D272 A:A:F246 85.37019.55NoNo099
14A:A:F246 A:A:F273 85.36254.29NoYes099
15A:A:F273 A:A:W277 79.640610.02YesYes396
16A:A:?358 A:A:W277 76.23876.65YesYes346
17B:B:?289 B:B:T274 25.16594.3YesYes278
18B:B:?289 B:B:D290 24.855.28YesYes276
19B:B:D290 B:B:R314 35.58037.15YesYes268
20A:A:?358 A:A:L394 80.91824.04YesYes347
21A:A:L394 R:R:I567 78.35084.28YesNo377
22B:B:D258 B:B:F222 18.92354.78YesYes278
23B:B:D258 B:B:R22 14.21879.53YesNo076
24B:B:I18 B:B:R22 12.63916.26NoNo076
25B:B:?289 B:B:W297 26.90957.75YesYes278
26B:B:?264 B:B:W297 19.620814.4YesYes258
27B:B:?57 B:B:W332 35.57698.83NoYes099
28B:B:?116 B:B:L117 17.60844.83YesNo099
29B:B:L117 B:B:W99 17.717810.25NoYes099
30B:B:?288 B:B:T274 10.40675.14NoYes278
31B:B:?288 B:B:I273 10.30094.98NoYes276
32B:B:?244 B:B:I273 28.18547.47YesYes056
33B:B:?289 B:B:I273 20.555312.49YesYes276
34B:B:?244 B:B:T243 23.18143.86YesYes058
35B:B:?250 B:B:I273 12.62826.11YesYes286
36B:B:?250 B:B:R251 15.58765.2YesYes288
37B:B:F253 B:B:R251 11.45788.55YesYes268
38R:R:I567 R:R:M571 78.39234.37NoYes378
39R:R:?546 R:R:M571 77.314412.37YesYes398
40R:R:?546 R:R:?623 76.97586.55YesYes399
41R:R:?623 R:R:M398 78.28828.25YesNo097
42R:R:?399 R:R:M398 77.85284.54YesNo087
43R:R:?399 R:R:L381 69.88137.41YesNo1585
44R:R:F403 R:R:L381 70.06753.65NoNo055
45R:R:?407 R:R:F403 70.91035.22YesNo075
46R:R:?407 R:R:?411 69.76385.77YesYes677
47R:R:?411 R:R:F515 68.2745.92YesYes679
48R:R:F515 R:R:L608 67.54673.65YesNo698
49R:R:?605 R:R:L608 67.5495.78NoNo098
50R:R:?605 R:R:E354 67.49544.74NoYes097
51R:R:?353 R:R:E354 70.90444.26NoYes097
52R:R:?280 R:R:?353 70.588215.87YesNo899
53R:R:?279 R:R:?280 69.177326.98NoYes899
54R:R:?279 R:R:F282 68.94316.52NoYes898
55R:R:F265 R:R:F282 68.45584.29NoYes878
56R:R:F265 R:R:P260 68.44648.67NoNo076
57R:R:P260 R:R:T264 67.2075.25NoNo064
58R:R:E243 R:R:T264 66.89314.23NoNo034
59R:R:?241 R:R:E243 66.83015.78YesNo073
60R:R:?223 R:R:?241 65.64854.21YesYes077
61R:R:?223 R:R:P224 65.264510.02YesNo078
62R:R:L202 R:R:P224 65.49214.93YesNo078
63R:R:L202 R:R:L204 53.41628.3YesNo079
64R:R:L181 R:R:L204 38.1744.15YesNo089
65R:R:?180 R:R:L181 26.79924.95YesYes058
66L:L:?113 R:R:?180 21.97484.02YesYes105
67R:R:L204 R:R:N207 15.18884.12NoNo099
68R:R:N158 R:R:N184 12.58555.45YesYes199
69R:R:N158 R:R:T133 18.721810.24YesYes098
70R:R:I135 R:R:T133 18.07217.6YesYes078
71R:R:F194 R:R:L202 11.76119.74YesYes097
72L:L:?113 L:L:H114 13.23357.5YesYes100
73L:L:H114 N:N:?113 11.68795.51YesYes100
74B:B:?59 B:B:W332 35.95837.75YesYes289
75B:B:F241 B:B:T243 14.29553.89YesYes268
76B:B:?272 B:B:D290 10.322414.2YesYes246
77B:B:?272 B:B:I273 10.1424.98YesYes246
78B:B:F222 B:B:F253 17.8544.29YesYes286
79B:B:?264 B:B:L252 13.13529.42YesNo057
80B:B:?57 B:B:Q75 35.61157.94NoNo099
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:?58 R:R:A57 6.13 0 Yes No 5 4 1 2
R:R:?58 R:R:L59 8.08 0 Yes Yes 5 7 1 2
R:R:?58 R:R:Q82 15.53 0 Yes Yes 5 6 1 1
N:N:?124 R:R:?58 5.62 0 Yes Yes 0 5 0 1
R:R:?77 R:R:E102 11.86 0 No Yes 5 7 2 1
R:R:Q82 R:R:S81 5.78 0 Yes No 6 6 1 2
R:R:N107 R:R:Q82 7.92 0 Yes Yes 7 6 1 1
L:L:T70 R:R:Q82 4.25 0 No Yes 0 6 0 1
R:R:?109 R:R:D84 4.05 1 Yes No 6 7 1 1
L:L:T70 R:R:D84 14.45 0 No No 0 7 0 1
R:R:E102 R:R:L104 6.63 1 Yes No 7 5 1 2
R:R:?127 R:R:E102 7.73 1 Yes Yes 6 7 2 1
L:L:T110 R:R:E102 7.06 1 Yes Yes 0 7 0 1
L:L:?112 R:R:E102 9.02 1 Yes Yes 0 7 0 1
R:R:?127 R:R:L104 6.73 1 Yes No 6 5 2 2
R:R:N107 R:R:Q106 7.92 0 Yes No 7 7 1 1
N:N:D119 R:R:Q106 6.53 0 Yes No 0 7 0 1
N:N:?121 R:R:Q106 4.64 0 No No 0 7 0 1
R:R:N107 R:R:N132 4.09 0 Yes Yes 7 8 1 1
L:L:M71 R:R:N107 8.41 0 No Yes 0 7 0 1
R:R:?109 R:R:N110 8.19 1 Yes No 6 5 1 2
R:R:?109 R:R:?134 4.32 1 Yes Yes 6 5 1 1
L:L:L72 R:R:?109 6.61 1 No Yes 0 6 0 1
R:R:?126 R:R:L125 4.13 1 Yes Yes 5 9 1 2
R:R:F151 R:R:L125 3.65 1 Yes Yes 5 9 2 2
R:R:?126 R:R:?127 14.46 1 Yes Yes 5 6 1 2
R:R:?126 R:R:E148 7.11 1 Yes No 5 5 1 1
R:R:?126 R:R:F151 6.54 1 Yes Yes 5 5 1 2
L:L:?112 R:R:?126 4.82 1 Yes Yes 0 5 0 1
R:R:?127 R:R:S129 8.76 1 Yes No 6 7 2 2
R:R:?127 R:R:E154 9.02 1 Yes Yes 6 7 2 1
R:R:E154 R:R:S129 14.37 1 Yes No 7 7 1 2
R:R:?131 R:R:N132 11.76 1 Yes Yes 7 8 2 1
R:R:?131 R:R:?156 31.75 1 Yes Yes 7 7 2 2
R:R:?131 R:R:D157 4.36 1 Yes Yes 7 6 2 1
R:R:D157 R:R:N132 12.12 1 Yes Yes 6 8 1 1
L:L:L72 R:R:N132 5.49 1 No Yes 0 8 0 1
L:L:V73 R:R:N132 7.39 0 No Yes 0 8 0 1
R:R:?134 R:R:I135 3.73 1 Yes Yes 5 7 1 2
R:R:?134 R:R:R136 6.36 1 Yes No 5 3 1 2
L:L:L72 R:R:?134 3.62 1 No Yes 0 5 0 1
L:L:?89 R:R:E148 3.87 0 Yes No 0 5 0 1
R:R:N150 R:R:S149 4.47 0 No No 5 3 1 1
R:R:E175 R:R:S149 8.62 0 No No 5 3 2 1
L:L:?99 R:R:S149 4.48 0 Yes No 0 3 0 1
L:L:E101 R:R:N150 3.94 0 No No 0 5 0 1
N:N:Q66 R:R:N150 14.52 0 No No 0 5 0 1
R:R:I152 R:R:T178 7.6 1 No No 4 6 1 1
L:L:?113 R:R:I152 4.16 1 Yes No 0 4 0 1
R:R:?156 R:R:E154 4.26 1 Yes Yes 7 7 2 1
L:L:?115 R:R:E154 6.32 1 Yes Yes 0 7 0 1
R:R:?156 R:R:D157 14.53 1 Yes Yes 7 6 2 1
R:R:?156 R:R:?182 4.32 1 Yes Yes 7 6 2 1
R:R:?156 R:R:N184 13.23 1 Yes Yes 7 9 2 2
N:N:R115 R:R:D157 8.34 1 No Yes 0 6 0 1
L:L:?113 R:R:T178 4.3 1 Yes No 0 6 0 1
R:R:?180 R:R:L181 4.95 1 Yes Yes 5 8 1 2
R:R:?180 R:R:?182 4.02 1 Yes Yes 5 6 1 1
R:R:?180 R:R:E203 5.53 1 Yes No 5 5 1 2
L:L:?113 R:R:?180 4.02 1 Yes Yes 0 5 0 1
R:R:?182 R:R:?183 15.26 1 Yes Yes 6 7 1 1
R:R:?182 R:R:N184 9.35 1 Yes Yes 6 9 1 2
R:R:?182 R:R:E203 19.33 1 Yes No 6 5 1 2
R:R:?182 R:R:?205 13.65 1 Yes No 6 7 1 2
N:N:R115 R:R:?182 11.82 1 No Yes 0 6 0 1
R:R:?183 R:R:N184 4.79 1 Yes Yes 7 9 1 2
R:R:?183 R:R:N207 5.99 1 Yes No 7 9 1 2
N:N:R115 R:R:?183 5.3 1 No Yes 0 7 0 1
R:R:?225 R:R:Q246 7.15 0 No No 3 6 1 2
R:R:R247 R:R:T226 9.06 0 No No 5 4 1 2
R:R:E270 R:R:R247 9.3 0 No No 6 5 2 1
N:N:P70 R:R:R247 11.53 0 No No 0 5 0 1
R:R:?331 R:R:D330 11.88 30 Yes No 1 4 1 2
R:R:D330 R:R:E332 3.9 30 No No 4 4 2 2
R:R:?331 R:R:E332 6.44 30 Yes No 1 4 1 2
R:R:?331 R:R:?333 6.55 30 Yes No 1 1 1 2
N:N:R63 R:R:?331 3.54 0 No Yes 0 1 0 1
R:R:?225 R:R:T226 3.52 0 No No 3 4 1 2
L:L:S67 R:R:?58 2.92 0 No Yes 0 5 0 1
N:N:V68 R:R:?225 2.67 0 No No 0 3 0 1
L:L:F41 R:R:?331 2.37 0 No Yes 0 1 0 1
L:L:V73 R:R:L159 1.49 0 No No 0 3 0 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
100.00Single6D35Cholesterol6D35-SMO-Cholesterol
100.00Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
100.00Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
100.00Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
100.00Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
100.00Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
100.00Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
100.00Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
100.00Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-PubChem 7023848
100.00Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
100.00Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626-Phospholipid
100.00Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
100.00Single7DTTCa7DTT-CaS-Ca-Ca
100.00Single7DTTCa7DTT-CaS-Ca-Ca
100.00Single7DTUTryptophan7DTU-CaS-Tryptophan
100.00Single7DTUTryptophan7DTU-CaS-Tryptophan
100.00Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
100.00Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
100.00Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
100.00Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
100.00Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
100.00Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
100.00Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
100.00Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
100.00Single7EB2Baclofen7EB2-GABAB2; GABAB1-Baclofen-rac-BHFF-Gi1/β1/γ2
100.00Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
100.00Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
100.00Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
100.00Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
100.00Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
100.00Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
100.00Single7FIIhCG7FII-LH-hCG-chim(NtGi1-Gs)/β1/γ2
100.00Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
100.00Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
100.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
100.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
100.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
100.00Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
100.00Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
100.00Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
100.00Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
100.00Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
100.00Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7T9NM22 Fab7T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
100.00Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
100.00Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
100.00Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
100.00Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
100.00Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
100.00Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
100.00Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
100.00Single7XW7K1-707XW7-TSH-K1-70
100.00Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
100.00Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
100.00Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
100.00Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
100.00Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
100.00Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
100.00Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
100.00Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
100.00Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
100.00Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
100.00Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
100.00Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
100.00Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-NAM563
100.00Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
100.00Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
100.00Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
100.00Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
100.00Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
100.00Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
100.00Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
100.00Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
100.00Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
100.00Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
100.00Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
100.00Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
100.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
100.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
100.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
100.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
100.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
100.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
100.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
100.00Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
100.00Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
100.00Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
100.00Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
100.00Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
100.00Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
100.00Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
100.00Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
100.00Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
100.00Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
100.00Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
100.00Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
100.00Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
100.00Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
100.00Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
100.00Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
100.00Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
100.00Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
100.00Single8WG9(2S)-2-amino-4-phosphonobutanoic acid8WG9-mGlu4; mGlu2-(2S)-2-amino-4-phosphonobutanoic acid
100.00Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
100.00Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
100.00Single8WGCLY3792688WGC-mGlu4; mGlu2-LY379268
100.00Single8WGDWAG/WA68WGD-mGlu4; mGlu2-WAG/WA6
100.00Single8WGDWAG/WA68WGD-mGlu4; mGlu2-WAG/WA6
100.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
100.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
100.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
100.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
100.00Single8WVXNorrin8WVX-LGR4-Norrin
100.00Single8WVYNorrin8WVY-LGR4-Norrin
100.00Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
100.00Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
100.00Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
100.00Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
100.00Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
100.00Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
100.00Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
100.00Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
100.00Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
100.00Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
100.00Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
100.00Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
100.00Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
100.00Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
100.00Single8XUMR-spondin-28XUM-LGR4-R-spondin-2
100.00Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
100.00Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
100.00Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
100.00Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
100.00Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
100.00Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
100.00Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
100.00Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
100.00Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
100.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
100.00Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
100.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
100.00Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
100.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
100.00Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
100.00Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
100.00Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
100.00Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
100.00Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
100.00Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
100.00Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
100.00Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
100.00Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
100.00Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
100.00Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
100.00Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
50.00Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
50.00Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
50.00Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
50.00Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
50.00Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
50.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
33.33Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
33.33Single7T9MCS-17 Antibody7T9M-TSH-CS-17 Antibody
25.00Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
25.00Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/β1/γ2
25.00Single7UTZTR14027UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
25.00Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/β1/γ2
25.00Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
20.00Single5L7DCholesterol5L7D-SMO-Cholesterol
20.00Single7T9ITSH7T9I-TSH-TSH-Gs/β1/γ2
20.00Single8HS2Fab0468HS2-GPR20-Fab046
20.00Single8I2GGlycoprotein hormones alpha chain8I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
20.00Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
20.00Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
16.67Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
16.67Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/β1/γ2
16.67Consensusp2y_offOrthosteric Ligandp2y1_off
14.29Single4XNWMRS25004XNW-P2Y1-MRS2500
14.29Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
14.29Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
14.29Single8JPSCCL78JPS-ACKR1-CCL7
14.29Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
14.29Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
12.50Single4O9RCyclopamine4O9R-SMO-Cyclopamine
12.50Single6LI0C176LI0-GPR52-C17
12.50Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
12.50Single8HSCFab0468HSC-GPR20-Fab046-Gi1/β1/γ2
12.50Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
12.50Single9B9Y7DY9B9Y-CB1-7DY
11.11Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
11.11Single4BWBNeurotensin4BWB-NTS1-Neurotensin
11.11Single4QINSAG1.54QIN-SMO-SAG1.5
11.11Single5U09Taranabant5U09-CB1-Taranabant
11.11Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
11.11Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
11.11Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
11.11Single7BR3Elagolix7BR3-GnRH1-Elagolix
11.11Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
11.11Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
11.11Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
11.11Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
11.11Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
11.11Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
11.11Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
11.11Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
11.11Single9BA0A1AKN9BA0-CB1-A1AKN
11.11Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
11.11Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
11.11Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
11.11Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
11.11Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
11.11Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
10.00Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
10.00Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
10.00Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
10.00Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
10.00Single7VV6C48/807VV6-MRGPRX2-C48/80
10.00Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
10.00Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
10.00Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
10.00Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
10.00Consensusgrh_offOrthosteric Ligandgnrh1_off
10.00Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
10.00Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
9.09Single4QIMANTA XV4QIM-SMO-ANTA XV
9.09Single5T04Neurotensin5T04-NTS1-Neurotensin
9.09Single5TGZAM65385TGZ-CB1-AM6538
9.09Single6D27CAY104716D27-DP2-CAY10471
9.09Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
9.09Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
9.09Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
9.09Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
9.09Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
9.09Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
9.09Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
9.09Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
9.09Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
9.09Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
9.09Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
9.09Single7YXAONO-54306087YXA-S1P5-ONO-5430608
9.09Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
9.09Single9B9ZA1AKO9B9Z-CB1-A1AKO
9.09Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
9.09Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
9.09Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
9.09Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
9.09Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
8.33Single4JKVTaladegib4JKV-SMO-Taladegib
8.33Single5C1MBU725C1M-μ-BU72
8.33Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
8.33Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
8.33Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
8.33Single7C4SS1P7C4S-S1P3-S1P
8.33Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
8.33Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
8.33Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
8.33Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
8.33Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
8.33Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
8.33Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
8.33Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
8.33Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
8.33Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
7.69Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
7.69Single4BV0Neurotensin4BV0-NTS1-Neurotensin
7.69Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
7.69Single5V56TC1145V56-SMO-TC114
7.69Single5V57TC1145V57-SMO-TC114
7.69Single6OS1TRV0266OS1-AT1-TRV026
7.69Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
7.69Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
7.69Single7F1TMIP-1a7F1T-CCR5-MIP-1a
7.69Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
7.69Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
7.69Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
7.69Single7R0CAVP7R0C-V2-AVP-Arrestin2
7.69Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
7.69Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
7.69Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
7.69Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
7.69Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
7.69Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
7.69Single8E0GBU728E0G-μ-BU72
7.69Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.69Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
7.69Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
7.69Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
7.69Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
7.69Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
7.69Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
7.69Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
7.69Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
7.69Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
7.69Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
7.69Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
7.69Consensuslpa_onOrthosteric Ligandlpa1_on
7.69Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
7.69Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Consensusneurotensin_onOrthosteric Ligandnts1_on
7.69Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
7.69Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
7.69Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
7.69Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
7.14Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
7.14Single4XEENeurotensin4XEE-NTS1-Neurotensin
7.14Single4XESNeurotensin4XES-NTS1-Neurotensin
7.14Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
7.14Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
7.14Single6OS2TRV0266OS2-AT1-TRV026
7.14Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
7.14Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
7.14Single6YVRNTS8-136YVR-NTS1-NTS8-13
7.14Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
7.14Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
7.14Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
7.14Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
7.14Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
7.14Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
7.14Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
7.14Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.14Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
7.14Single8XQJJN2418XQJ-Apelin-JN241
7.14Single8XWACXCL18XWA-CXCR2-CXCL1
7.14Single8XWMCXCL68XWM-CXCR2-CXCL6
7.14Single8XWSCXCL58XWS-CXCR2-CXCL5
7.14Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
7.14Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
7.14Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
7.14Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
7.14Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
7.14Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
7.14Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
7.14Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
7.14Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
7.14Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
7.14Consensuslpa_offOrthosteric Ligandlpa1_off
7.14Consensuslpl_offOrthosteric Ligands1p_off lpa_off
7.14Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
7.14Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
7.14Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
7.14Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
7.14Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
7.14Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
7.14Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
6.67Single4BUONeurotensin4BUO-NTS1-Neurotensin
6.67Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
6.67Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
6.67Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
6.67Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
6.67Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
6.67Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
6.67Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
6.67Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
6.67Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
6.67Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
6.67Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-PubChem 118610427-chim(NtGi1-Go)/β1/γ2
6.67Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
6.67Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
6.67Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
6.67Single8XVUCXCL28XVU-CXCR2-CXCL2
6.67Single8XWFCXCL38XWF-CXCR2-CXCL3
6.67Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
6.67Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
6.67Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
6.67Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(CtGi1-G13)/β1/γ2
6.67Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
6.67Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
6.67Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
6.67Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
6.25Single6KNMJN241-96KNM-Apelin-JN241-9
6.25Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
6.25Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
6.25Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
6.25Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
6.25Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
6.25Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
6.25Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
6.25Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
6.25Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
6.25Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25Single8QJ2pN1628QJ2-MC4-pN162-Gs
6.25Single8XQJJN2418XQJ-Apelin-JN241
6.25Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
6.25Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
6.25Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
6.25Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
6.25Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
6.25Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
6.25Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
5.88Single4XT1Fractalkine4XT1-US28-Fractalkine
5.88Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
5.88Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
5.88Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
5.88Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
5.88Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
5.88Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
5.88Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
5.88Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
5.88Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
5.88Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
5.88Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/β1/γ2
5.88Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.88Single8XFTR-spondin-28XFT-LGR4-R-spondin-2-ZNRF3
5.88Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
5.88Single8XWNCXCL88XWN-CXCR2-CXCL8
5.88Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-Cholesterol-ZNRF3
5.88Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
5.88Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
5.88Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
5.88Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
5.88Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
5.88Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
5.88Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
5.88Consensuslpl_onOrthosteric Ligands1p_on lpa_on
5.88Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
5.88Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
5.88Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
5.56Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
5.56Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
5.56Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
5.56Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
5.56Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
5.56Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
5.56Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
5.56Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
5.56Single7SK5CXCL127SK5-ACKR3-CXCL12
5.56Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
5.56Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
5.56Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
5.56Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
5.56Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
5.56Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
5.56Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
5.56Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
5.56Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
5.56Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
5.56Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
5.26Single3OE0CVX153OE0-CXCR4-CVX15
5.26Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
5.26Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
5.26Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
5.26Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
5.26Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.26Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
5.26Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
5.26Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
5.26Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
5.26Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
5.26Single8WVUR-spondin-18WVU-LGR4-R-spondin-1-RNF43
5.26Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
5.26Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-Cholesterol-ZNRF3
5.26Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
5.26Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
5.26Consensusangiotensin_onOrthosteric Ligandat1_on
5.26Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
5.26Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
5.26Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
5.26Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
5.26Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
5.26Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
5.26Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
5.26Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
5.26Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
5.00Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
5.00Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
5.00Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
5.00Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
5.00Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
5.00Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
5.00Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
5.00Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
5.00Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
5.00Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
5.00Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
5.00Single8XFPR-spondin-28XFP-LGR4-R-spondin-2-ZNRF3
5.00Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
5.00Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
5.00Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ22
5.00Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
5.00Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
5.00Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
5.00Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
5.00Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
5.00Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
5.00Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
5.00Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
5.00Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
5.00Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
5.00Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
5.00Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
5.00Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
5.00Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
5.00Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
5.00Consensusvasop-oxy_onOrthosteric Ligandv2_on
5.00Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
4.76Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
4.76Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
4.76Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
4.76Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
4.76Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
4.76Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
4.76Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
4.76Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
4.76Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
4.76Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
4.76Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
4.76Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
4.76Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
4.76Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
4.76Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
4.76Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
4.76Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
4.76Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
4.76Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
4.76Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
4.76Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
4.76Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
4.76Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
4.76Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
4.76Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
4.76Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
4.76Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
4.76Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
4.55Single4XT3Fractalkine4XT3-US28-Fractalkine
4.55Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
4.55Single6FJ3PTH6FJ3-PTH1-PTH
4.55Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
4.55Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
4.55Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
4.55Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
4.55Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
4.55Single7SK3CXCL127SK3-ACKR3-CXCL12
4.55Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
4.55Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
4.55Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
4.55Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
4.55Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
4.55Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
4.55Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
4.55Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
4.55Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
4.55Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
4.55Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
4.55Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
4.55Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
4.55Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
4.55Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
4.35Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
4.35Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
4.35Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
4.35Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
4.35Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
4.35Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
4.35Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
4.35Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
4.35Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
4.35Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
4.35Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
4.35Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
4.35Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
4.35Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
4.35Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
4.35Single8XFSR-spondin-28XFS-LGR4-R-spondin-2-ZNRF3
4.35Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
4.35Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
4.35Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
4.35Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
4.35Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
4.35Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
4.35Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
4.35Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
4.17Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
4.17Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
4.17Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
4.17Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
4.17Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
4.17Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
4.17Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
4.17Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
4.17Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
4.17Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
4.17Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
4.17Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
4.17Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
4.17Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
4.17Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
4.17Single8IY6Endothelin-18IY6-ETB-Endothelin-1
4.17Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
4.17Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
4.17Consensusbradykinin_onOrthosteric Ligandbk2_on
4.17Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
4.17Consensusendothelin_onOrthosteric Ligandetb_on eta_on
4.17Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
4.17Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
4.00Single5GLHEndothelin-15GLH-ETB-Endothelin-1
4.00Single6IGKEndothelin-36IGK-ETB-Endothelin-3
4.00Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
4.00Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/β1/γ2
4.00Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
4.00Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
4.00Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
4.00Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
4.00Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
4.00Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
3.85Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
3.85Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
3.85Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
3.85Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
3.85Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
3.85Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
3.85Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
3.85Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
3.85Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
3.85Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
3.85Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
3.70Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
3.70Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
3.70Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
3.70Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
3.70Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
3.70Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
3.70Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
3.57Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
3.57Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
3.57Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
3.57Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
3.57Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
3.57Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
3.57Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
3.57Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
3.45Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
3.33Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
3.33Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
3.23Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
3.12Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
3.03Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
2.78Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1

2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:?510 R:R:F350 7.99 0 No No 6 8 2 1
R:R:F350 W:W:?801 6.26 0 No Yes 8 0 1 0
R:R:P352 R:R:V601 7.07 0 No No 9 8 2 1
R:R:?612 R:R:M408 9.62 6 Yes No 7 8 1 2
R:R:?411 R:R:T446 11.47 6 Yes No 7 8 2 2
R:R:?411 R:R:F515 5.92 6 Yes Yes 7 9 2 1
R:R:F515 R:R:T446 5.19 6 Yes No 9 8 1 2
R:R:?612 R:R:S450 7.3 6 Yes No 7 8 1 2
R:R:?508 R:R:?514 23.07 6 Yes Yes 8 9 2 2
R:R:?508 R:R:P516 7.99 6 Yes No 8 9 2 1
R:R:I513 R:R:V511 4.61 6 No No 9 9 2 2
R:R:?514 R:R:V511 4.79 6 Yes No 9 9 2 2
R:R:M517 R:R:V511 6.09 0 No No 8 9 1 2
R:R:F515 R:R:I513 8.79 6 Yes No 9 9 1 2
R:R:I513 R:R:L608 8.56 6 No No 9 8 2 2
R:R:?514 R:R:F515 3.91 6 Yes Yes 9 9 2 1
R:R:F515 R:R:P516 4.33 6 Yes No 9 9 1 1
R:R:F515 R:R:L608 3.65 6 Yes No 9 8 1 2
R:R:?612 R:R:F515 10.66 6 Yes Yes 7 9 1 1
R:R:F515 W:W:?801 12.52 6 Yes Yes 9 0 1 0
R:R:P516 W:W:?801 6.03 6 No Yes 9 0 1 0
R:R:M517 W:W:?801 21.8 0 No Yes 8 0 1 0
R:R:Q525 R:R:V519 5.73 0 No No 6 6 2 1
R:R:?527 R:R:I528 11.11 18 Yes No 7 6 2 1
R:R:I528 W:W:?801 5.24 0 No Yes 6 0 1 0
R:R:A589 R:R:L532 4.73 0 No No 9 9 1 2
R:R:A589 W:W:?801 6.94 0 No Yes 9 0 1 0
R:R:A592 W:W:?801 4.63 0 No Yes 9 0 1 0
R:R:?595 R:R:P597 4.9 0 No No 6 5 2 1
R:R:P597 W:W:?801 6.03 0 No Yes 5 0 1 0
R:R:V601 W:W:?801 5.47 0 No Yes 8 0 1 0
R:R:S604 W:W:?801 9.92 0 No Yes 6 0 1 0
R:R:?612 R:R:P613 19.17 6 Yes No 7 9 1 2
R:R:?612 W:W:?801 3.95 6 Yes Yes 7 0 1 0
R:R:V519 W:W:?801 3.28 0 No Yes 6 0 1 0
R:R:A349 W:W:?801 2.31 0 No Yes 8 0 1 0
R:R:A349 R:R:D348 1.54 0 No No 8 9 1 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
71.43Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
66.67Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
61.54Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
56.25Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
50.00Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
50.00Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
47.37Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
47.06Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
46.15Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
44.44Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
44.44Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-PubChem 118610427-chim(NtGi1-Go)/β1/γ2
42.86Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
42.11Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
42.11Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
41.18Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
40.00Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
40.00Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
38.89Single4XEENeurotensin4XEE-NTS1-Neurotensin
38.89Single4XESNeurotensin4XES-NTS1-Neurotensin
38.89Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
38.89Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
38.89Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
38.89Single8XWSCXCL58XWS-CXCR2-CXCL5
38.89Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
38.89Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
38.89Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
38.46Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
38.10Single3QAKUK-4320973QAK-A2A-UK-432097
37.50Single4QIMANTA XV4QIM-SMO-ANTA XV
37.50Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
37.50Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
37.50Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
36.84Single4BUONeurotensin4BUO-NTS1-Neurotensin
36.84Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
36.84Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
36.84Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
36.84Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
36.84Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
36.36Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
36.00Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
36.00Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
36.00Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
35.29Single5N2SPSB365N2S-A1-PSB36
35.29Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
35.29Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
35.29Single8GNEKW-63568GNE-A2A-KW-6356-Na
35.29Single8QOTNanobody-E8QOT-μ-Nanobody-E
35.29Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
35.00Single5WF6UK-4320975WF6-A2A-UK-432097
34.78Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
33.33Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
33.33Single4BV0Neurotensin4BV0-NTS1-Neurotensin
33.33Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
33.33Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
33.33Single5V56TC1145V56-SMO-TC114
33.33Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
33.33Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
33.33Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
33.33Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
33.33Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
33.33Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
33.33Single7PX4PSB-21137PX4-A2A-PSB-2113
33.33Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
33.33Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
33.33Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
33.33Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
33.33Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
33.33Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
33.33Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
33.33Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
33.33Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
33.33Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
33.33Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
33.33Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Consensusneurotensin_onOrthosteric Ligandnts1_on
33.33Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
33.33Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
33.33Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
32.00Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
31.82Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
31.82Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
31.82Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
31.58Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
31.58Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
31.58Single6OS2TRV0266OS2-AT1-TRV026
31.58Single6YVRNTS8-136YVR-NTS1-NTS8-13
31.58Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
31.58Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
31.58Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
31.58Single8XWACXCL18XWA-CXCR2-CXCL1
31.58Single8XWMCXCL68XWM-CXCR2-CXCL6
31.58Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
31.58Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
31.58Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
31.58Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
31.25Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
31.25Single5IU7Q274563465IU7-A2A-Q27456346-Na
31.25Single5IUBQ274563445IUB-A2A-Q27456344-Na
31.25Single5JTBZM-2413855JTB-A2A-ZM-241385
31.25Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
31.25Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
31.25Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
31.25Single5UVIZM-2413855UVI-A2A-ZM-241385
31.25Single6MH8ZM-2413856MH8-A2A-ZM-241385
31.25Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
31.25Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
31.25Single7VV6C48/807VV6-MRGPRX2-C48/80
31.25Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
31.25Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
31.25Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
31.25Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
31.25Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
31.25Consensusa2_offOrthosteric Liganda2a_off
31.25Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
31.25Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
30.77Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
30.77Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
30.43Single5WF5UK-4320975WF5-A2A-UK-432097
30.43Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
30.43Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
30.43Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
30.43Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
30.00Single7EZCUKA7EZC-A2A-UKA
30.00Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
30.00Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
30.00Single8XVUCXCL28XVU-CXCR2-CXCL2
30.00Single8XWFCXCL38XWF-CXCR2-CXCL3
30.00Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
30.00Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
30.00Consensuscck_onOrthosteric Ligandccka_on cckb_on
30.00Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
29.63Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
29.41Single3EMLZM-2413853EML-A2A-ZM-241385
29.41Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
29.41Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
29.41Single5IU8Q274563475IU8-A2A-Q27456347-Na
29.41Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
29.41Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
29.41Single5T04Neurotensin5T04-NTS1-Neurotensin
29.41Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
29.41Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
29.41Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
29.41Single6S0LZM-2413856S0L-A2A-ZM-241385
29.41Single7PYRPSB-21157PYR-A2A-PSB-2115
29.41Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
29.41Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
29.41Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
29.41Consensusa3_onOrthosteric Liganda3a_on
29.41Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
29.41Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
29.41Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
29.17Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
29.17Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
29.17Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Single4XNWMRS25004XNW-P2Y1-MRS2500
28.57Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
28.57Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
28.57Single7V6A-7V6A-M4-PubChem 9864275-Gi1/β1/γ2
28.57Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
28.57Single8QJ2pN1628QJ2-MC4-pN162-Gs
28.57Single8XQJJN2418XQJ-Apelin-JN241
28.57Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
28.57Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
28.57Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
28.57Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
28.57Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
28.57Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
28.00Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
28.00Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
28.00Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
28.00Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
28.00Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
28.00Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
27.78Single4JKVTaladegib4JKV-SMO-Taladegib
27.78Single5IUAQ274563485IUA-A2A-Q27456348-Na
27.78Single5N2RPSB-365N2R-A2A-PSB-36-Na
27.78Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
27.78Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
27.78Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
27.78Single6S0QZM-2413856S0Q-A2A-ZM-241385
27.78Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
27.78Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
27.78Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/β1/γ2
27.78Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
27.78Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
27.78Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
27.78Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
27.78Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
27.78Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
27.78Consensusa3_on_gpOrthosteric Liganda3a_on_gp
27.78Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
27.78Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
27.78Consensusadenosine_offOrthosteric Liganda1_off a2_off
27.27Single7F8XNN90567F8X-CCKA-NN9056
27.27Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
27.27Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
27.27Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
27.27Single8XWNCXCL88XWN-CXCR2-CXCL8
27.27Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
27.27Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
27.27Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
27.27Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
26.92Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
26.92Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
26.92Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
26.92Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
26.92Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
26.67Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
26.67Single4O9RCyclopamine4O9R-SMO-Cyclopamine
26.67Single7UL2SR486927UL2-NTS1-SR48692-Na
26.67Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
26.67Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
26.67Consensusneurotensin_offOrthosteric Ligandnts1_off
26.67Consensusnts1_offOrthosteric Ligand7UL2-NTS1-SR48692-Na
26.32Single5V57TC1145V57-SMO-TC114
26.32Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
26.32Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
26.32Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
26.32Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
26.32Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
26.32Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
26.32Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
26.32Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
26.32Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
26.32Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
26.32Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
26.32Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
26.32Consensusrelaxin_onOrthosteric Ligandrxfp4_on
26.32Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
26.09Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
26.09Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
26.09Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
26.09Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
26.09Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
26.09Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
26.09Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
26.09Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
26.09Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
26.09Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
25.93Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
25.93Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
25.93Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
25.93Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
25.00Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
25.00Single3OE0CVX153OE0-CXCR4-CVX15
25.00Single3PWHZM-2413853PWH-A2A-ZM-241385
25.00Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
25.00Single4BWBNeurotensin4BWB-NTS1-Neurotensin
25.00Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
25.00Single4QINSAG1.54QIN-SMO-SAG1.5
25.00Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
25.00Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
25.00Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
25.00Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
25.00Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
25.00Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
25.00Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
25.00Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
25.00Single8GNGIstradefylline8GNG-A2A-Istradefylline
25.00Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
25.00Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
25.00Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
25.00Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
25.00Single8IY6Endothelin-18IY6-ETB-Endothelin-1
25.00Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
25.00Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
25.00Single8XQJJN2418XQJ-Apelin-JN241
25.00Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
25.00Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
25.00Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
25.00Consensusbradykinin_onOrthosteric Ligandbk2_on
25.00Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
25.00Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
25.00Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
25.00Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
25.00Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
25.00Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
25.00Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
25.00Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
25.00Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
25.00Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
24.14Single5GLHEndothelin-15GLH-ETB-Endothelin-1
24.14Single6IGKEndothelin-36IGK-ETB-Endothelin-3
24.00Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
24.00Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
24.00Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
24.00Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
24.00Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
24.00Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
24.00Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
24.00Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
24.00Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
24.00Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
24.00Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
24.00Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
24.00Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
24.00Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
24.00Consensusvasop-oxy_onOrthosteric Ligandv2_on
24.00Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
23.81Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
23.81Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
23.81Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
23.81Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
23.81Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
23.81Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
23.81Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
23.81Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
23.81Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(CtGi1-G13)/β1/γ2
23.81Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
23.81Consensuschemerin_onOrthosteric Ligandcml1_on
23.81Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.81Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.81Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
23.81Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
23.53Single2YDOAdenosine2YDO-A2A-Adenosine
23.53Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
23.53Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
23.53Single6AQFZM-2413856AQF-A2A-ZM-241385
23.53Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
23.53Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
23.53Single7AROLUF58337ARO-A2A-LUF5833-Na
23.53Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
23.53Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
23.53Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
23.53Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
23.53Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
23.53Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
23.53Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
23.53Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
23.53Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
23.53Consensusgrh_offOrthosteric Ligandgnrh1_off
23.53Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
23.33Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
23.33Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
23.08Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
23.08Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
23.08Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
23.08Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
23.08Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
23.08Single8PWNTheophylline8PWN-A2A-Theophylline
23.08Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
23.08Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
23.08Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
23.08Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
23.08Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
23.08Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
23.08Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
23.08Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
22.73Single4UG2CGS216804UG2-A2A-CGS21680
22.73Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
22.73Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
22.73Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
22.73Single7XN9L-054,5227XN9-SST2-L-054,522
22.73Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
22.73Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
22.73Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
22.73Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
22.73Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
22.73Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
22.73Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
22.73Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
22.58Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
22.58Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
22.58Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
22.22Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
22.22Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
22.22Single5UENDU1725UEN-A1-DU172
22.22Single6FJ3PTH6FJ3-PTH1-PTH
22.22Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
22.22Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
22.22Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
22.22Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
22.22Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
22.22Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
22.22Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
22.22Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
22.22Single8CU6LJ-45178CU6-A2A-LJ-4517
22.22Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
22.22Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
22.22Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
22.22Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
22.22Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
22.22Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
22.22Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
22.22Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
22.22Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
22.22Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
22.22Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
22.22Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
22.22Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
22.22Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
22.22Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
22.22Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
22.22Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
22.22Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
21.88Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
21.88Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
21.74Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
21.74Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
21.74Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
21.74Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.74Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
21.74Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
21.74Single8WDTphotoNECA8WDT-A2A-photoNECA
21.74Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
21.74Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
21.74Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
21.74Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
21.74Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
21.74Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
21.74Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
21.74Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
21.74Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
21.74Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
21.74Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
21.74Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
21.43Single3RFMCaffeine3RFM-A2A-Caffeine
21.43Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
21.43Single8A2OTheophylline8A2O-A2A-Theophylline-Na
21.43Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
21.43Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
21.43Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/β1/γ2
21.43Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
21.43Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
21.43Consensusp2y_offOrthosteric Ligandp2y1_off
21.05Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
21.05Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
21.05Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
21.05Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
21.05Single6Z4SSR486926Z4S-NTS1-SR48692
21.05Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
21.05Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
21.05Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
21.05Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
21.05Single8WGBW9R8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
21.05Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
21.05Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
21.05Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
21.05Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
21.05Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
20.83Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
20.83Single7SK5CXCL127SK5-ACKR3-CXCL12
20.83Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
20.83Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
20.83Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
20.83Single7XNACYN1548067XNA-SST2-CYN154806
20.83Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
20.83Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
20.83Single8IEBA1LYA8IEB-GPR156-A1LYA
20.83Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
20.83Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
20.83Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
20.83Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
20.83Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
20.69Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
20.69Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
20.69Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
20.69Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
20.69Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
20.69Consensusendothelin_onOrthosteric Ligandetb_on eta_on
20.69Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
20.00Single2YDVNECA2YDV-A2A-NECA
20.00Single3UZAGTPL92363UZA-A2A-GTPL9236
20.00Single4UHRCGS216804UHR-A2A-CGS21680
20.00Single5G53NECA5G53-A2A-NECA-Gs
20.00Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
20.00Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
20.00Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
20.00Single6J21Aprepitant6J21-NK1-Aprepitant
20.00Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
20.00Single6ME5Agomelatine6ME5-MT1-Agomelatine
20.00Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
20.00Single6OS1TRV0266OS1-AT1-TRV026
20.00Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
20.00Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
20.00Single7F1TMIP-1a7F1T-CCR5-MIP-1a
20.00Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
20.00Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
20.00Single7R0CAVP7R0C-V2-AVP-Arrestin2
20.00Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
20.00Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
20.00Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
20.00Single7TUYGSK682753A7TUY-GPR183-GSK682753A
20.00Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
20.00Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
20.00Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
20.00Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
20.00Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
20.00Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
20.00Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
20.00Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
20.00Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
20.00Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
20.00Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
20.00Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single8JPSCCL78JPS-ACKR1-CCL7
20.00Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
20.00Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
20.00Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
20.00Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
20.00Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
20.00Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
20.00Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
20.00Single9GE2ML1849GE2-GPR55-ML184-Cholesterol-chim(CtGi1-G13)/β1/γ2
20.00Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
20.00Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
20.00Consensusa2_onOrthosteric Liganda2b_on
20.00Consensusa2_on_gpOrthosteric Liganda2b_on_gp
20.00Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
20.00Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
20.00Consensusangiotensin_onOrthosteric Ligandat1_on
20.00Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
20.00Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
20.00Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
20.00Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
20.00Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
20.00Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
20.00Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
20.00Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
20.00Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
20.00Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
20.00Consensuslpa_onOrthosteric Ligandlpa1_on
20.00Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
20.00Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
19.35Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
19.35Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
19.35Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
19.23Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
19.23Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
19.23Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
19.23Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
19.23Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
19.23Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
19.23Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
19.23Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
19.23Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
19.23Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
19.23Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
19.23Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
19.23Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
19.23Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
19.05Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
19.05Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
19.05Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
19.05Single4RWADIPP-NH24RWA-δ-DIPP-NH2
19.05Single6MXTSalmeterol6MXT-β2-Salmeterol
19.05Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
19.05Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
19.05Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
19.05Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
19.05Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
19.05Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
19.05Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
19.05Single8JWY2-1188JWY-A2A-2-118
19.05Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
19.05Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
19.05Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
19.05Single8ZPLHF511168ZPL-CXCR4-HF51116-Cholesterol
19.05Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
19.05Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
19.05Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
19.05Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
19.05Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
19.05Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
19.05Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
18.75Single3OE9IT1t3OE9-CXCR4-IT1t
18.75Single5L7IVismodegib5L7I-SMO-Vismodegib
18.75Single6HLLCP999946HLL-NK1-CP99994
18.75Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
18.75Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
18.75Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
18.75Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
18.75Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.75Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
18.75Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
18.75Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
18.75Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
18.75Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
18.75Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
18.75Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
18.75Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
18.75Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
18.75Consensusgq_nucleotideOrthosteric Ligandgq_p2y
18.75Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
18.52Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
18.52Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
18.52Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
18.52Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
18.52Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.52Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
18.52Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
18.52Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
18.52Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
18.52Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
18.52Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
18.52Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
18.52Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
18.52Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
18.52Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
18.52Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
18.18Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
18.18Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
18.18Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
18.18Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
18.18Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
18.18Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
18.18Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
18.18Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
18.18Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
18.18Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
18.18Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.18Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
18.18Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
18.18Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
18.18Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
18.18Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
18.18Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
17.86Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
17.86Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
17.86Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
17.86Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
17.86Single7SK3CXCL127SK3-ACKR3-CXCL12
17.86Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
17.86Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
17.86Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
17.65Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
17.65Single5U09Taranabant5U09-CB1-Taranabant
17.65Single5ZKQABT-4915ZKQ-PAF-ABT-491
17.65Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
17.65Single6ME9Ramelteon6ME9-MT2-Ramelteon
17.65Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
17.65Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
17.65Single7BR3Elagolix7BR3-GnRH1-Elagolix
17.65Single7F8ULintitript7F8U-CCKA-Lintitript
17.65Single7F8YDevazepide7F8Y-CCKA-Devazepide
17.65Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
17.65Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
17.65Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
17.65Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
17.65Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
17.65Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
17.65Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
17.65Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
17.65Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
17.65Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
17.65Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
17.65Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
17.65Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
17.65Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
17.65Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
17.65Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
17.39Single3NY9ICI118-5513NY9-β2-ICI118-551
17.39Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
17.39Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
17.39Single6KNMJN241-96KNM-Apelin-JN241-9
17.39Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
17.39Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.39Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
17.39Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
17.39Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
17.39Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
17.39Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
17.39Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
17.39Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
17.39Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
17.39Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
17.24Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
17.24Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
17.24Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
17.24Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
17.24Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
17.24Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
17.24Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
17.24Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
17.24Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
16.67Single3REYXAC3REY-A2A-XAC
16.67Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
16.67Single4IARErgotamine4IAR-5-HT1B-Ergotamine
16.67Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
16.67Single4XT1Fractalkine4XT1-US28-Fractalkine
16.67Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
16.67Single6IGLIRL16206IGL-ETB-IRL1620
16.67Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
16.67Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
16.67Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
16.67Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
16.67Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
16.67Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
16.67Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
16.67Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
16.67Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
16.67Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
16.67Single7QA8Peptide7QA8-STE2-Peptide
16.67Single7QA8Peptide7QA8-STE2-Peptide
16.67Single7T32ZM-2413857T32-A2A-ZM-241385
16.67Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
16.67Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
16.67Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
16.67Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
16.67Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
16.67Single8IEBA1LYA8IEB-GPR156-A1LYA
16.67Single8IEPA1LYA8IEP-GPR156-A1LYA
16.67Single8IEPA1LYA8IEP-GPR156-A1LYA
16.67Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
16.67Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
16.67Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
16.67Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
16.67Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
16.67Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
16.67Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
16.67Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
16.67Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
16.67Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
16.67Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Cholesterol-Gi1/β1/γ2
16.67Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
16.67Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
16.67Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
16.67Consensushca_onOrthosteric Ligandhca2_on
16.67Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
16.67Consensussomatostatin_offOrthosteric Ligandsst2_off
16.13Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/β1/γ2
16.13Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
16.13Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
16.13Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
16.13Consensusbombesin_onOrthosteric Ligandbb2_on
16.13Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
16.13Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
16.13Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
16.00Single6HLOAprepitant6HLO-NK1-Aprepitant
16.00Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
16.00Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
16.00Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
16.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
16.00Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
16.00Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
16.00Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
16.00Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
16.00Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
16.00Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
16.00Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
16.00Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
15.79Single2Y02Carmoterol2Y02-β1-Carmoterol
15.79Single4EJ4Naltrindole4EJ4-δ-Naltrindole
15.79Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
15.79Single5TGZAM65385TGZ-CB1-AM6538
15.79Single5UIGCmpd-15UIG-A2A-Cmpd-1
15.79Single6D27CAY104716D27-DP2-CAY10471
15.79Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
15.79Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
15.79Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
15.79Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
15.79Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
15.79Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
15.79Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
15.79Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
15.79Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
15.79Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
15.79Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
15.79Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
15.79Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
15.79Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
15.79Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.79Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
15.79Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
15.79Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
15.79Single8RLNLUF58348RLN-A2A-LUF5834
15.79Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
15.79Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
15.79Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
15.79Single9B9ZA1AKO9B9Z-CB1-A1AKO
15.79Single9CHXS-Carazolol9CHX-β2-S-Carazolol
15.79Single9IYAONO-97105319IYA-GPR55-ONO-9710531
15.79Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
15.79Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
15.79Consensuscck_offOrthosteric Ligandccka_off
15.79Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
15.79Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
15.79Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
15.79Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
15.79Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
15.79Consensushca_on_gpOrthosteric Ligandhca2_on_gp
15.62Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
15.62Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
15.62Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
15.62Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
15.62Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
15.38Single5MZPCaffeine5MZP-A2A-Caffeine-Na
15.38Single6PT2KGCHM076PT2-δ-KGCHM07
15.38Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
15.38Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
15.38Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
15.38Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
15.38Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
15.38Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
15.38Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
15.15Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
15.15Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
15.15Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.00Single4NTJAZD12834NTJ-P2Y12-AZD1283
15.00Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
15.00Single5X7DS-Carazolol5X7D-β2-S-Carazolol-PubChem 129318963
15.00Single6D26Fevipiprant6D26-DP2-Fevipiprant
15.00Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
15.00Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
15.00Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
15.00Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
15.00Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
15.00Single7C61Ergotamine7C61-5-HT1B-Ergotamine
15.00Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
15.00Single7SINNPS-21437SIN-CaS-NPS-2143
15.00Single7SINNPS-21437SIN-CaS-NPS-2143
15.00Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
15.00Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
15.00Single7W41PD1762527W41-BB2-PD176252
15.00Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
15.00Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.00Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
15.00Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
15.00Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.00Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
15.00Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
15.00Single8S4DCMF-0198S4D-Apelin-CMF-019
15.00Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
15.00Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
15.00Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
15.00Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
15.00Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
15.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
15.00Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
15.00Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
15.00Consensusbombesin_offOrthosteric Ligandbb2_off
15.00Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
15.00Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
15.00Consensusdp_offOrthosteric Liganddp2_off
15.00Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
15.00Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
15.00Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
15.00Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
15.00Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
14.81Single6JODAngiotensin II6JOD-AT2-Angiotensin II
14.81Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
14.81Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
14.81Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
14.81Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
14.81Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
14.81Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
14.81Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
14.81Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
14.81Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
14.81Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
14.81Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
14.81Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
14.81Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
14.81Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
14.81Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
14.71Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
14.71Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
14.29Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
14.29Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
14.29Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
14.29Single5TZRMK86665TZR-FFA1-MK8666
14.29Single5XRAAM115425XRA-CB1-AM11542
14.29Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
14.29Single6J20Aprepitant6J20-NK1-Aprepitant
14.29Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
14.29Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
14.29Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
14.29Single6WGTLSD6WGT-5-HT2A-LSD
14.29Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
14.29Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
14.29Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
14.29Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
14.29Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
14.29Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
14.29Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
14.29Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
14.29Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
14.29Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
14.29Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
14.29Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
14.29Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
14.29Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
14.29Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
14.29Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
14.29Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
14.29Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
14.29Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
14.29Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
14.29Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
14.29Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
14.29Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
14.29Single8ZRTET-18ZRT-ETB-ET-1
14.29Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
14.29Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
14.29Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
14.29Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
14.29Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
14.29Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
14.29Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
14.29Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
14.29Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
14.29Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
14.29Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
14.29Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
14.29Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
14.29Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
14.29Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
14.29Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
14.29Consensustachykinin_offOrthosteric Ligandnk1_off
13.89Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
13.89Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
13.79Single4XT3Fractalkine4XT3-US28-Fractalkine
13.79Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
13.64Single4AMIBucindolol4AMI-β1-Bucindolol
13.64Single4N4WSANT-14N4W-SMO-SANT-1
13.64Single4PY02MeSATP4PY0-P2Y12-2MeSATP
13.64Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
13.64Single5TZYMK8666; PubChem 1270535975TZY-FFA1-MK8666; PubChem 127053597
13.64Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
13.64Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
13.64Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
13.64Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
13.64Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
13.64Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
13.64Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
13.64Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
13.64Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
13.64Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
13.64Single7K15MKD0467K15-BLT1-MKD046-Na
13.64Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
13.64Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
13.64Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.64Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
13.64Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
13.64Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
13.64Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
13.64Single8JJLOlodaterol8JJL-β2-Olodaterol
13.64Single8JWZAB9288JWZ-A2A-AB928-Na
13.64Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
13.64Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
13.64Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
13.64Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
13.64Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
13.64Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
13.64Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
13.64Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
13.64Consensuslpa_offOrthosteric Ligandlpa1_off
13.64Consensuslpl_offOrthosteric Ligands1p_off lpa_off
13.64Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
13.64Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
13.64Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
13.64Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
13.64Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
13.64Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
13.64Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
13.64Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.64Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.33Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
13.33Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
13.33Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
13.33Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
13.33Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
13.33Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
13.33Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
13.33Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
13.33Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
13.33Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
13.33Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
13.33Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
13.04Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
13.04Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
13.04Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
13.04Single6IBLArformoterol6IBL-β1-Arformoterol
13.04Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
13.04Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
13.04Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
13.04Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
13.04Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
13.04Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
13.04Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
13.04Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
13.04Single7UM4AS26747237UM4-5-HT5A-AS2674723
13.04Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
13.04Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.04Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
13.04Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
13.04Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
13.04Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.04Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
13.04Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
13.04Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
13.04Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
13.04Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
13.04Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
13.04Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
13.04Consensusprostanoid_offOrthosteric Ligandep_off dp_off
12.90Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
12.90Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
12.90Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
12.90Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
12.90Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
12.50Single3OE6IT1t3OE6-CXCR4-IT1t
12.50Single5ZTYAM102575ZTY-CB2-AM10257
12.50Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
12.50Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
12.50Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
12.50Single6PT3DPI-2876PT3-δ-DPI-287
12.50Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
12.50Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
12.50Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
12.50Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
12.50Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
12.50Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
12.50Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
12.50Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
12.50Single7WC5Psilocin7WC5-5-HT2A-Psilocin
12.50Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
12.50Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
12.50Single8IEIA1LYA8IEI-GPR156-A1LYA
12.50Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
12.50Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
12.50Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
12.50Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
12.50Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
12.50Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
12.50Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
12.50Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
12.50Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
12.50Consensusgi_sensoryOrthosteric Ligandgi_opsins
12.50Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
12.50Consensuskisspeptin_onOrthosteric Ligandkiss1_on
12.50Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
12.50Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
12.50Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
12.50Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
12.12Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
12.12Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
12.00Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
12.00Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
12.00Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
12.00Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
12.00Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
12.00Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
12.00Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
12.00Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
12.00Single8IEIA1LYA8IEI-GPR156-A1LYA
12.00Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
12.00Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/β1/γ2
12.00Single8WKYPG-9348WKY-MC4-PG-934
12.00Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
12.00Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
12.00Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
12.00Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
12.00Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
12.00Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
12.00Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
12.00Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
12.00Consensuslpl_onOrthosteric Ligands1p_on lpa_on
12.00Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
11.90Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
11.76Single3PBLEticlopride3PBL-D3-Eticlopride
11.76Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
11.76Single6LI0C176LI0-GPR52-C17
11.76Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
11.76Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
11.76Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
11.76Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
11.76Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
11.76Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
11.76Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
11.76Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
11.76Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
11.76Single8K5BNiacin8K5B-HCA2-Niacin
11.76Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
11.76Single9B9Y7DY9B9Y-CB1-7DY
11.76Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
11.76Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
11.76Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
11.76Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
11.76Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
11.76Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
11.54Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
11.54Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
11.54Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
11.54Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
11.54Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
11.54Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
11.54Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
11.43Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
11.11Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
11.11Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
11.11Single3ODUIT1t3ODU-CXCR4-IT1t
11.11Single4S0VSuvorexant4S0V-OX2-Suvorexant
11.11Single6DS0Ly2660976DS0-5-HT2B-Ly266097
11.11Single6ME2Ramelteon6ME2-MT1-Ramelteon
11.11Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
11.11Single6TPJSuvorexant6TPJ-OX2-Suvorexant
11.11Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
11.11Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
11.11Single6W25SHU91196W25-MC4-SHU9119-Ca
11.11Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
11.11Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
11.11Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
11.11Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
11.11Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
11.11Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
11.11Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
11.11Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
11.11Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
11.11Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
11.11Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.11Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
11.11Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
11.11Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
11.11Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
11.11Single8IWESpermidine8IWE-TA9-Spermidine
11.11Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
11.11Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
11.11Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
11.11Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.11Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.11Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.11Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.11Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
11.11Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
11.11Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
11.11Single9BA0A1AKN9BA0-CB1-A1AKN
11.11Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
11.11Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
11.11Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
11.11Consensusalpha2_offOrthosteric Ligandalpha2c_off
11.11Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
11.11Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
11.11Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
11.11Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
11.11Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
10.71Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
10.71Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
10.71Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
10.71Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
10.71Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
10.71Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ22
10.71Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
10.53Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
10.53Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
10.53Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
10.53Single6KUXRS-799486KUX-α2a-RS-79948
10.53Single6PS0S-Carazolol6PS0-β2-S-Carazolol
10.53Single6PS4ICI118-5516PS4-β2-ICI118-551
10.53Single6PS5S-Propranolol6PS5-β2-S-Propranolol
10.53Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
10.53Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
10.53Single6TP3Nemorexant6TP3-OX1-Nemorexant
10.53Single6TPKRetosiban6TPK-OT-Retosiban
10.53Single6V9SGTPL114036V9S-OX1-GTPL11403
10.53Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
10.53Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
10.53Single6ZINSR486926ZIN-NTS1-SR48692
10.53Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
10.53Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
10.53Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
10.53Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
10.53Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
10.53Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
10.53Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
10.53Single7UL3Famotidine7UL3-H2-Famotidine
10.53Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
10.53Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
10.53Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
10.53Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
10.53Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
10.53Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.53Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.53Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
10.53Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
10.53Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
10.53Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
10.53Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
10.53Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
10.53Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
10.53Single8IHKAcifran8IHK-HCA3-Acifran
10.53Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
10.53Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.53Single8K5CAcipimox8K5C-HCA2-Acipimox
10.53Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
10.53Single8K9LDamgo8K9L-μ-Damgo-VV9-Gi3/β1/γ1
10.53Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
10.53Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.53Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.53Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.53Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.53Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.53Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
10.53Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
10.53Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
10.53Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
10.53Single8ZPNAMD31008ZPN-CXCR4-AMD3100-Cholesterol
10.53Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
10.53Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
10.53Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
10.53Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
10.53Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
10.53Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
10.53Consensusvasop-oxy_offOrthosteric Ligandot_off
10.34Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
10.34Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
10.34Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
10.34Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
10.26Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
10.00Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
10.00Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
10.00Single3NY8ICI118-5513NY8-β2-ICI118-551
10.00Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
10.00Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
10.00Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
10.00Single4GBRS-Carazolol4GBR-β2-S-Carazolol
10.00Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
10.00Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
10.00Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
10.00Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
10.00Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
10.00Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
10.00Single6PS1Timolol6PS1-β2-Timolol
10.00Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
10.00Single6TOTLemborexant6TOT-OX1-Lemborexant
10.00Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.00Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
10.00Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
10.00Single7BU7BI1671077BU7-β1-BI167107
10.00Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
10.00Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
10.00Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
10.00Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
10.00Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
10.00Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
10.00Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
10.00Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
10.00Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
10.00Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
10.00Single7UL4Alvimopan7UL4-μ-Alvimopan
10.00Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
10.00Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
10.00Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
10.00Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
10.00Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
10.00Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
10.00Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
10.00Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
10.00Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
10.00Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
10.00Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
10.00Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
10.00Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
10.00Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.00Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.00Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.00Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.00Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.00Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.00Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.00Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.00Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.00Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.00Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
10.00Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
10.00Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
10.00Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
10.00Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
10.00Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
10.00Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
10.00Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
10.00Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
10.00Single8JJOAlprenolol8JJO-β2-Alprenolol
10.00Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
10.00Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
10.00Single8K5DGSK2560738K5D-HCA2-GSK256073
10.00Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
10.00Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
10.00Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
10.00Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
10.00Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.00Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.00Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.00Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.00Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.00Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.00Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.00Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
10.00Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
10.00Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
10.00Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
10.00Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
10.00Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
10.00Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
10.00Consensus5ht5_onOrthosteric Ligand5ht5a_on
10.00Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
10.00Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
10.00Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
10.00Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
10.00Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
10.00Consensusdopamine_offOrthosteric Ligandd2_off d3_off
10.00Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
10.00Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
10.00Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
9.68Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
9.52Single2RH1S-Carazolol2RH1-β2-S-Carazolol
9.52Single2YCWS-Carazolol2YCW-β1-S-Carazolol
9.52Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
9.52Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
9.52Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
9.52Single5C1MBU725C1M-μ-BU72
9.52Single5D6LS-Carazolol5D6L-β2-S-Carazolol
9.52Single5JQHS-Carazolol5JQH-β2-S-Carazolol
9.52Single5TVNLSD5TVN-5-HT2B-LSD
9.52Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
9.52Single6E67BI1671076E67-β2-BI167107-Gs (fused)
9.52Single6HLPNetupitant6HLP-NK1-Netupitant
9.52Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
9.52Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
9.52Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
9.52Single6PS6Timolol6PS6-β2-Timolol
9.52Single6TP6Filorexant6TP6-OX1-Filorexant
9.52Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
9.52Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
9.52Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
9.52Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
9.52Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
9.52Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
9.52Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
9.52Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
9.52Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
9.52Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
9.52Single7WC6LSD7WC6-5-HT2A-LSD
9.52Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
9.52Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
9.52Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
9.52Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
9.52Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
9.52Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
9.52Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.52Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.52Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.52Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
9.52Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
9.52Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
9.52Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
9.52Single8TF5Oleic acid8TF5-GPR6-Oleic acid
9.52Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.52Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.52Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
9.52Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
9.52Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
9.52Single8XYKVUF106618XYK-CXCR3-VUF10661-Go1/β1/γ2
9.52Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
9.52Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
9.52Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
9.52Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
9.52Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
9.52Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
9.52Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
9.52Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
9.52Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
9.52Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
9.52Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
9.52Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
9.52Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
9.52Consensusamine_offonOrthosteric Ligandamine_off amine_on
9.52Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
9.52Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
9.52Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
9.52Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
9.52Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
9.52Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
9.52Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
9.52Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
9.52Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
9.52Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
9.52Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
9.52Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
9.52Consensustrace-amine_onOrthosteric Ligandta1_on
9.38Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
9.38Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
9.38Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
9.09Single3P0GBI1671073P0G-β2-BI167107
9.09Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
9.09Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
9.09Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
9.09Single5D5AS-Carazolol5D5A-β2-S-Carazolol
9.09Single5D5BS-Carazolol5D5B-β2-S-Carazolol
9.09Single5V54Methiothepin5V54-5-HT1B-Methiothepin
9.09Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
9.09Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
9.09Single6D35Cholesterol6D35-SMO-Cholesterol
9.09Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
9.09Single6E59L-7607356E59-NK1-L-760735
9.09Single6H7JIsoprenaline6H7J-β1-Isoprenaline
9.09Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
9.09Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
9.09Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
9.09Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
9.09Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
9.09Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
9.09Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
9.09Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
9.09Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
9.09Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
9.09Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
9.09Single7B6WCyclazosin7B6W-α1b-Cyclazosin
9.09Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-PubChem 7023848
9.09Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
9.09Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626-Phospholipid
9.09Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
9.09Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
9.09Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
9.09Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
9.09Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
9.09Single7DTTCa7DTT-CaS-Ca-Ca
9.09Single7DTTCa7DTT-CaS-Ca-Ca
9.09Single7DTUTryptophan7DTU-CaS-Tryptophan
9.09Single7DTUTryptophan7DTU-CaS-Tryptophan
9.09Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
9.09Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
9.09Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
9.09Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
9.09Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
9.09Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
9.09Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
9.09Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
9.09Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
9.09Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
9.09Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
9.09Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
9.09Single7EB2Baclofen7EB2-GABAB2; GABAB1-Baclofen-rac-BHFF-Gi1/β1/γ2
9.09Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
9.09Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
9.09Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
9.09Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
9.09Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
9.09Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
9.09Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
9.09Single7FEECP559407FEE-CB1-CP55940-ZCZ011
9.09Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
9.09Single7FIIhCG7FII-LH-hCG-chim(NtGi1-Gs)/β1/γ2
9.09Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
9.09Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
9.09Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
9.09Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
9.09Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
9.09Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
9.09Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
9.09Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
9.09Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
9.09Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
9.09Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
9.09Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
9.09Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
9.09Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
9.09Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
9.09Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
9.09Single7P2L4YI7P2L-mGlu5-4YI
9.09Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
9.09Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
9.09Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
9.09Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
9.09Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
9.09Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
9.09Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
9.09Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
9.09Single7T9NM22 Fab7T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
9.09Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
9.09Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
9.09Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
9.09Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
9.09Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
9.09Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
9.09Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
9.09Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
9.09Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
9.09Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
9.09Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
9.09Single7XW7K1-707XW7-TSH-K1-70
9.09Single8E0GBU728E0G-μ-BU72
9.09Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
9.09Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
9.09Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
9.09Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
9.09Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
9.09Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
9.09Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
9.09Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
9.09Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
9.09Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
9.09Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
9.09Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
9.09Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
9.09Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
9.09Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
9.09Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-NAM563
9.09Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
9.09Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
9.09Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
9.09Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
9.09Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
9.09Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
9.09Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
9.09Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
9.09Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
9.09Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
9.09Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
9.09Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
9.09Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
9.09Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
9.09Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
9.09Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
9.09Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
9.09Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
9.09Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
9.09Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
9.09Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
9.09Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
9.09Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
9.09Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
9.09Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
9.09Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
9.09Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
9.09Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
9.09Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
9.09Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
9.09Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
9.09Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
9.09Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
9.09Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
9.09Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
9.09Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
9.09Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
9.09Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
9.09Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
9.09Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
9.09Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
9.09Single8WG9(2S)-2-amino-4-phosphonobutanoic acid8WG9-mGlu4; mGlu2-(2S)-2-amino-4-phosphonobutanoic acid
9.09Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
9.09Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
9.09Single8WGCLY3792688WGC-mGlu4; mGlu2-LY379268
9.09Single8WGDWAG/WA68WGD-mGlu4; mGlu2-WAG/WA6
9.09Single8WGDWAG/WA68WGD-mGlu4; mGlu2-WAG/WA6
9.09Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
9.09Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
9.09Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.09Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.09Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
9.09Single8WVXNorrin8WVX-LGR4-Norrin
9.09Single8WVYNorrin8WVY-LGR4-Norrin
9.09Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
9.09Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
9.09Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
9.09Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
9.09Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
9.09Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
9.09Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
9.09Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
9.09Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
9.09Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
9.09Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
9.09Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
9.09Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
9.09Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
9.09Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
9.09Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
9.09Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Cholesterol-Gi1/β1/γ1
9.09Single8XUMR-spondin-28XUM-LGR4-R-spondin-2
9.09Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
9.09Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
9.09Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
9.09Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
9.09Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
9.09Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
9.09Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
9.09Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
9.09Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
9.09Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
9.09Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
9.09Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
9.09Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
9.09Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
9.09Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
9.09Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
9.09Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
9.09Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
9.09Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
9.09Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
9.09Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
9.09Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
9.09Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
9.09Consensus5ht1_offOrthosteric Ligand5ht1b_off
9.09Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
9.09Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
9.09Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
9.09Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
9.09Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
9.09Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
9.09Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
9.09Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
9.09Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
9.09Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
8.82Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
8.70Single3D4STimolol3D4S-β2-Timolol
8.70Single4LDEBI1671074LDE-β2-BI167107
8.70Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
8.70Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
8.70Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
8.70Single6KQICP559406KQI-CB1-CP55940-Org27569
8.70Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
8.70Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
8.70Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
8.70Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
8.70Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
8.70Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
8.70Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
8.70Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
8.70Single7YITNalfurafine7YIT-κ-Nalfurafine
8.70Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.70Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
8.70Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
8.70Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
8.70Single8JJ8Formoterol8JJ8-β2-Formoterol
8.70Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
8.70Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
8.70Single8XYIVUF106618XYI-CXCR3-VUF10661
8.70Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
8.70Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
8.70Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
8.70Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
8.70Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
8.70Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
8.70Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
8.70Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
8.70Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
8.70Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
8.70Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
8.70Consensusorexin_onOrthosteric Ligandox2_on
8.70Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
8.33Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
8.33Single6H7LDobutamine6H7L-β1-Dobutamine
8.33Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
8.33Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
8.33Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
8.33Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
8.33Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
8.33Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
8.33Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
8.33Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
8.33Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
8.33Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
8.33Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
8.33Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
8.33Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
8.33Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
8.33Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
8.33Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
8.33Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
8.33Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
8.33Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
8.33Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
8.33Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
8.33Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
8.33Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
8.33Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
8.00Single5EE7MK08935EE7-Glucagon-MK0893
8.00Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
8.00Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
8.00Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
8.00Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
8.00Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
7.69Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
7.69Single7T9MCS-17 Antibody7T9M-TSH-CS-17 Antibody
7.69Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
7.69Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
7.69Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
7.69Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
7.69Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
7.41Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
7.41Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
7.41Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
7.41Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
7.41Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
7.14Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
7.14Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/β1/γ2
7.14Single7UTZTR14027UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
7.14Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/β1/γ2
7.14Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
7.14Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
7.14Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/β1/γ2
7.14Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
7.14Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
6.90Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
6.67Single5L7DCholesterol5L7D-SMO-Cholesterol
6.67Single7T9ITSH7T9I-TSH-TSH-Gs/β1/γ2
6.67Single7WC4Serotonin7WC4-5-HT2A-Serotonin
6.67Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
6.67Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
6.67Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
6.67Single8HS2Fab0468HS2-GPR20-Fab046
6.67Single8I2GGlycoprotein hormones alpha chain8I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
6.67Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
6.25Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
6.25Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
6.25Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
6.25Single7Y14Beta-Alanine7Y14-MRGPRD-β-Alanine
6.25Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
6.25Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
6.25Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
6.25Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
6.25Consensussensory_onOrthosteric Ligandopsins_on
5.88Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
5.88Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
5.88Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
5.88Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.88Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
5.88Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
5.88Single7Y12Beta-Alanine7Y12-MRGPRD-β-Alanine-Gi1/β1/γ2
5.88Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.88Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.88Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
5.88Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
5.88Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
5.88Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
5.88Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
5.88Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
5.88Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
5.88Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
5.88Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
5.88Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
5.88Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
5.88Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
5.88Consensus5ht2_onOrthosteric Ligand5ht2b_on
5.88Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.88Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
5.88Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
5.88Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
5.88Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
5.88Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
5.56Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
5.56Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
5.56Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
5.56Single6TP4ACT-4622066TP4-OX1-ACT-462206
5.56Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.56Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
5.56Single7SRQLSD7SRQ-5-HT2B-LSD
5.56Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
5.56Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
5.56Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
5.56Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
5.56Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
5.56Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
5.56Single8HSCFab0468HSC-GPR20-Fab046-Gi1/β1/γ2
5.56Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
5.56Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
5.56Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
5.56Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
5.56Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
5.56Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
5.56Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
5.56Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
5.56Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
5.56Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
5.56Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.56Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go1/β1/γ2
5.56Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.56Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
5.56Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
5.56Single8YN7Immethridine8YN7-H3-Immethridine-Go1/β1/γ2
5.56Single8YRGFospropofol8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
5.56Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
5.56Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
5.56Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
5.26Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
5.26Single5WS3EMPA5WS3-OX2-EMPA
5.26Single6AKXA4R6AKX-CCR5-A4R
5.26Single6B73MP11046B73-κ-MP1104
5.26Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
5.26Single6TODEMPA6TOD-OX1-EMPA-Na
5.26Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
5.26Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
5.26Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
5.26Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
5.26Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
5.26Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
5.26Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.26Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.26Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
5.26Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
5.26Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
5.26Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
5.26Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
5.26Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
5.26Single7XRRLemborexant7XRR-OX2-Lemborexant
5.26Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
5.26Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.26Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
5.26Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.26Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.26Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
5.26Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
5.26Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
5.26Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
5.26Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
5.26Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
5.26Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.26Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
5.26Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/β1/γ2
5.26Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
5.26Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
5.26Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
5.26Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
5.26Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
5.26Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
5.26Single8Y0HVUF114188Y0H-CXCR3-VUF11418
5.26Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
5.26Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ
5.26Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
5.26Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
5.26Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
5.26Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
5.26Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.26Consensusangiotensin_offOrthosteric Ligandat1_off
5.26Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
5.26Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
5.26Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
5.26Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
5.26Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
5.26Consensusorexin_offOrthosteric Ligandox2_off ox1_off
5.26Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
5.26Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
5.26Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
5.26Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
5.26Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
5.26Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
5.26Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
5.00Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
5.00Single3RZECidoxepin3RZE-H1-Cidoxepin
5.00Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
5.00Single4MBSMaraviroc4MBS-CCR5-Maraviroc
5.00Single4ZJCSB-6740424ZJC-OX1-SB-674042
5.00Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
5.00Single6A94Zotepine6A94-5-HT2A-Zotepine
5.00Single6FFIMMPEP6FFI-mGlu5-MMPEP
5.00Single6IQLL7458706IQL-D4-L745870
5.00Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
5.00Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
5.00Single6TPGEMPA6TPG-OX2-EMPA
5.00Single6TPNHTL66416TPN-OX2-HTL6641
5.00Single6VI4JDTic6VI4-κ-JDTic
5.00Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
5.00Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
5.00Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
5.00Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
5.00Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
5.00Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
5.00Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
5.00Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.00Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.00Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
5.00Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
5.00Single7VODCariprazine7VOD-5-HT2A-Cariprazine
5.00Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
5.00Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
5.00Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
5.00Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
5.00Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
5.00Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
5.00Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
5.00Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.00Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
5.00Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
5.00Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
5.00Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
5.00Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
5.00Single8JD6N-(3-chlorophenyl)pyridine-2-carboxamide8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
5.00Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
5.00Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
5.00Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
5.00Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
5.00Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.00Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
5.00Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
5.00Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
5.00Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
5.00Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
5.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
5.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.00Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
5.00Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
5.00Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
5.00Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
5.00Single8YN8Proxyfan8YN8-H3-Proxyfan-Go1/β1/γ2
5.00Single8ZPMAMD0708ZPM-CXCR4-AMD070-Cholesterol
5.00Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
5.00Single9BJKNaloxone9BJK-μ-Naloxone-NAM
5.00Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
5.00Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
5.00Consensusalpha1_onOrthosteric Ligandalpha1a_on
5.00Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
5.00Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
5.00Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
5.00Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
5.00Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
5.00Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
5.00Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
5.00Consensusopsins_offOrthosteric Ligandrhodopsin_off
5.00Consensussensory_offOrthosteric Ligandopsins_off
4.76Single2Y01Dobutamine2Y01-β1-Dobutamine
4.76Single2Y04Salbutamol2Y04-β1-Salbutamol
4.76Single4DAJTiotropium4DAJ-M3-Tiotropium
4.76Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
4.76Single4MQSIperoxo4MQS-M2-Iperoxo
4.76Single4QKX35V4QKX-β2-35V
4.76Single4U14Tiotropium4U14-M3-Tiotropium
4.76Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
4.76Single4YAYZD-71554YAY-AT1-ZD-7155
4.76Single5DHGC-355DHG-NOP-C-35
4.76Single5DHHSB-6121115DHH-NOP-SB-612111
4.76Single5DSGTiotropium5DSG-M4-Tiotropium
4.76Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
4.76Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
4.76Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
4.76Single6DRXLisuride6DRX-5-HT2B-Lisuride
4.76Single6FFHFenobam6FFH-mGlu5-Fenobam
4.76Single6H7MSalbutamol6H7M-β1-Salbutamol
4.76Single6IIVDaltroban6IIV-TP-Daltroban
4.76Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
4.76Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/β1/γ2
4.76Single7F83PF-051904577F83-Ghrelin-PF-05190457
4.76Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
4.76Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
4.76Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
4.76Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
4.76Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
4.76Single7V3ZCP559407V3Z-CB1-CP55940
4.76Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
4.76Single7WC7Lisuride7WC7-5-HT2A-Lisuride
4.76Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
4.76Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
4.76Single7YXAONO-54306087YXA-S1P5-ONO-5430608
4.76Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
4.76Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
4.76Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
4.76Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
4.76Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
4.76Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
4.76Single8PJKST1718PJK-5-HT1A-ST171-t7m-Gi1/β1/γ1
4.76Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
4.76Single8T1WCVN4248T1W-GPR6-CVN424
4.76Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
4.76Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
4.76Single8X63Mepyramine8X63-H1-Mepyramine
4.76Single8X64Desloratadine8X64-H1-Desloratadine
4.76Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
4.76Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
4.76Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
4.76Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
4.76Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
4.76Consensusalpha2_onOrthosteric Ligandalpha2b_on
4.76Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
4.76Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
4.76Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
4.76Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
4.76Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
4.76Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
4.76Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
4.76Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
4.76Consensushistamine_offOrthosteric Ligandh1_off
4.76Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
4.76Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
4.76Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
4.55Single2Y00Dobutamine2Y00-β1-Dobutamine
4.55Single2Y03Isoprenaline2Y03-β1-Isoprenaline
4.55Single5WIUNemonapride5WIU-D4-Nemonapride
4.55Single5WIVNemonapride5WIV-D4-Nemonapride-Na
4.55Single5WQCEMPA5WQC-OX2-EMPA
4.55Single5XPRBosentan5XPR-ETB-Bosentan
4.55Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
4.55Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
4.55Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
4.55Single6LUQHaloperidol6LUQ-D2-Haloperidol
4.55Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
4.55Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
4.55Single7C4SS1P7C4S-S1P3-S1P
4.55Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
4.55Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
4.55Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
4.55Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
4.55Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
4.55Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.55Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
4.55Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
4.55Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
4.55Single8JXSPF-61428JXS-D1-PF-6142
4.55Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
4.55Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
4.55Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
4.55Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
4.55Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
4.55Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
4.55Single8ZMFA1L108ZMF-5-HT2C-A1L10
4.55Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
4.55Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
4.55Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
4.55Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
4.55Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
4.55Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
4.55Consensusblt_offOrthosteric Ligandblt1_off
4.55Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
4.55Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
4.55Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
4.55Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
4.55Consensusep_offOrthosteric Ligandep4_off
4.55Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
4.55Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
4.55Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
4.55Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
4.55Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.55Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.35Single4DJHJDTic4DJH-κ-JDTic
4.35Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
4.35Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
4.35Single4U15Tiotropium4U15-M3-Tiotropium
4.35Single5XR8AM8415XR8-CB1-AM841
4.35Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
4.35Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
4.35Single6OL9Tiotropium6OL9-M5-Tiotropium
4.35Single6TQ7SB-3348676TQ7-OX1-SB-334867
4.35Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
4.35Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
4.35Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
4.35Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
4.35Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
4.35Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
4.35Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
4.35Single8EA0Iperoxo8EA0-M3-Iperoxo
4.35Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
4.35Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
4.35Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
4.35Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
4.35Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
4.35Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
4.35Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
4.35Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
4.35Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
4.35Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
4.35Single8XVLZibotentan8XVL-ETA-Zibotentan
4.35Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
4.35Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
4.35Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
4.35Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
4.35Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
4.35Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
4.35Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
4.35Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
4.35Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
4.35Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
4.35Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
4.35Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
4.35Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
4.17Single5CXVTiotropium5CXV-M1-Tiotropium
4.17Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
4.17Single6A93Risperidone6A93-5-HT2A-Risperidone
4.17Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
4.17Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
4.17Single6IIURamatroban6IIU-TP-Ramatroban
4.17Single7DFPSpiperone7DFP-D2-Spiperone
4.17Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
4.17Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
4.17Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
4.17Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
4.17Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
4.17Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
4.17Single8XJNCloprosetnol8XJN-TP-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
4.17Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
4.17Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
4.17Consensusalpha1_offOrthosteric Ligandalpha1a_off
4.17Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
4.17Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
4.17Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
4.17Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
4.00Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
4.00Single5X93K-87945X93-ETB-K-8794
4.00Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
4.00Single6K1QIRL25006K1Q-ETB-IRL2500
4.00Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
4.00Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
4.00Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
4.00Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
4.00Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00Single8XVJMacitentan8XVJ-ETA-Macitentan
4.00Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
4.00Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
4.00Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
4.00Consensusendothelin_offOrthosteric Ligandetb_off
4.00Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
4.00Consensusfp-alpha_onOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
4.00Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
4.00Consensustp_onOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00Consensustp_on_gpOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
3.85Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
3.85Single7SK9CCX6627SK9-ACKR3-CCX662
3.85Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
3.85Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
3.85Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
3.85Single8X5YAstemizole8X5Y-H1-Astemizole
3.70Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
3.70Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
3.70Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
3.70Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
3.70Single8KIGSHU91198KIG-MC3-SHU9119-Ca
3.70Single8PKMBefiradol8PKM-5-HT1A-Befiradol-t7m-Gi1/β1/γ1
3.70Single8XFTR-spondin-28XFT-LGR4-R-spondin-2-ZNRF3
3.70Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-Cholesterol-ZNRF3
3.57Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
3.45Single8WVUR-spondin-18WVU-LGR4-R-spondin-1-RNF43
3.45Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-Cholesterol-ZNRF3
3.33Single8XFPR-spondin-28XFP-LGR4-R-spondin-2-ZNRF3
3.33Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
3.03Single8XFSR-spondin-28XFS-LGR4-R-spondin-2-ZNRF3

PDB Summary
PDB 7FIH
Class A
SubFamily Protein
Type Glycoprotein Hormone
SubType LH
Species Homo Sapiens
Ligand hCG
Other Ligand(s) Org43553
Protein Partners chim(NtGi1-Gs)/Beta1/Gamma2
PDB Resolution 3.2
Date 2021-09-29
D.O.I. 10.1038/s41586-021-03924-2
Net Summary
Imin 3.62
Number of Linked Nodes 1366
Number of Links 1738
Number of Hubs 301
Number of Links mediated by Hubs 1128
Number of Communities 34
Number of Nodes involved in Communities 393
Number of Links involved in Communities 599
Path Summary
Number Of Nodes in MetaPath 81
Number Of Links MetaPath 80
Number of Shortest Paths 4367977
Length Of Smallest Path 3
Average Path Length 37.7509
Length of Longest Path 80
Minimum Path Strength 0.835
Average Path Strength 7.78218
Maximum Path Strength 29.555
Minimum Path Correlation 0.73
Average Path Correlation 0.997865
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 4.16667
Average % Of Corr. Nodes 53.13
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 59.2606
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier• Cystine-knot cytokines   • Cystine-knot cytokines   • Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Cystine-knot cytokines   • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeCMS
PDB ResiduesA:A:?10 A:A:?237 A:A:?359 A:A:?365 A:A:?379 B:B:?25 B:B:?103 B:B:?114 B:B:?121 B:B:?148 B:B:?149 B:B:?166 B:B:?204 B:B:?218 B:B:?233 B:B:?250 B:B:?271 B:B:?294 B:B:?317 G:G:?41 R:R:?131 R:R:?156 R:R:?279 R:R:?280 R:R:?336 R:R:?343 R:R:?353 R:R:?399 R:R:?407 R:R:?439 R:R:?514 R:R:?543 R:R:?545 R:R:?581 R:R:?617 R:R:?643 R:R:?644 L:L:?31 L:L:?34 L:L:?52 L:L:?55 L:L:?56 L:L:?83 L:L:?84 L:L:?106 L:L:?108 L:L:?111 N:N:?29 N:N:?43 N:N:?46 N:N:?54 N:N:?58 N:N:?77 N:N:?92 N:N:?108 N:N:?110 N:N:?113 N:N:?120 N:N:?130
Environment DetailsOpen EMBL-EBI Page
CodeCMS
NameCARBAMOYL SARCOSINE
Synonyms
Identifier
FormulaC4 H8 N2 O3
Molecular Weight132.118
SMILES
PubChem439375
Formal Charge0
Total Atoms17
Total Chiral Atoms0
Total Bonds16
Total Aromatic Bonds0

CodeLMS
PDB ResiduesA:A:?17 A:A:?24 A:A:?28 A:A:?32 A:A:?34 A:A:?53 A:A:?58 A:A:?203 A:A:?211 A:A:?216 A:A:?233 A:A:?274 A:A:?293 A:A:?300 A:A:?305 A:A:?307 A:A:?338 B:B:?15 B:B:?23 B:B:?57 B:B:?78 B:B:?89 B:B:?127 B:B:?209 B:B:?280 B:B:?301 B:B:?337 G:G:?14 G:G:?20 G:G:?29 G:G:?32 G:G:?46 R:R:?62 R:R:?77 R:R:?109 R:R:?126 R:R:?137 R:R:?143 R:R:?180 R:R:?205 R:R:?212 R:R:?225 R:R:?233 R:R:?257 R:R:?258 R:R:?339 R:R:?390 R:R:?423 R:R:?477 R:R:?510 R:R:?548 R:R:?563 R:R:?566 R:R:?569 R:R:?570 R:R:?595 R:R:?605 R:R:?628 R:R:?640 L:L:?68 L:L:?69 L:L:?75 L:L:?87 L:L:?99 L:L:?115 N:N:?22 N:N:?40 N:N:?124
Environment DetailsOpen EMBL-EBI Page
CodeLMS
Name[(2r,3s,4r,5r)-5-(6-Amino-9h-Purin-9-Yl)-3,4-Dihydroxytetrahydro-2-Furanyl]Methyl Sulfamate
Synonyms[(2r,3s,4r,5r)-5-(6-Amino-9h-Purin-9-Yl)-3,4-Dihydroxytetrahydro-2-Furanyl]Methyl Sulfamate
Identifier
FormulaC10 H14 N6 O6 S
Molecular Weight346.32
SMILES
PubChem97576
Formal Charge0
Total Atoms37
Total Chiral Atoms4
Total Bonds39
Total Aromatic Bonds10

CodeTMR
PDB ResiduesA:A:?37 A:A:?63 A:A:?253 A:A:?311 A:A:?318 A:A:?339 A:A:?358 A:A:?360 A:A:?391 B:B:?59 B:B:?85 B:B:?105 B:B:?111 B:B:?124 B:B:?145 B:B:?264 B:B:?289 G:G:?40 R:R:?58 R:R:?113 R:R:?127 R:R:?182 R:R:?240 R:R:?254 R:R:?275 R:R:?331 R:R:?333 R:R:?359 R:R:?389 R:R:?411 R:R:?426 R:R:?427 R:R:?455 R:R:?470 R:R:?508 R:R:?527 R:R:?546 R:R:?550 R:R:?612 R:R:?623 L:L:?61 L:L:?89 L:L:?112 L:L:?113 N:N:?57 N:N:?79 N:N:?102
Environment DetailsOpen EMBL-EBI Page
CodeTMR
Name2,6-dideoxy-4-S-methyl-4-thio-beta-D-ribo-hexopyranose
Synonyms2,6-DIDEOXY-4-THIOMETHYL-BETA-D-RIBOHEXOPYRANOSIDE; 2,6-dideoxy-4-S-methyl-4-thio-beta-D-ribo-hexose; 2,6-dideoxy-4-S-methyl-4-thio-D-ribo-hexose; 2,6-dideoxy-4-S-methyl-4-thio-ribo-hexose
Identifier
FormulaC7 H14 O3 S
Molecular Weight178.249
SMILES
PubChem447846
Formal Charge0
Total Atoms25
Total Chiral Atoms4
Total Bonds25
Total Aromatic Bonds0

CodeGLM
PDB ResiduesA:A:?47 A:A:?52 A:A:?206 A:A:?225 A:A:?304 A:A:?329 A:A:?353 A:A:?355 B:B:?41 B:B:?53 B:B:?64 B:B:?77 B:B:?109 B:B:?115 B:B:?116 B:B:?131 B:B:?141 B:B:?144 B:B:?162 B:B:?174 B:B:?182 B:B:?185 B:B:?202 B:B:?216 B:B:?224 B:B:?238 B:B:?244 B:B:?272 B:B:?282 B:B:?288 B:B:?306 B:B:?310 B:B:?319 B:B:?324 B:B:?330 R:R:?71 R:R:?117 R:R:?134 R:R:?166 R:R:?171 R:R:?183 R:R:?185 R:R:?196 R:R:?216 R:R:?220 R:R:?223 R:R:?241 R:R:?334 R:R:?358 R:R:?376 R:R:?409 R:R:?424 R:R:?436 R:R:?438 R:R:?443 R:R:?489 R:R:?490 R:R:?504 R:R:?642 L:L:?46 L:L:?54 L:L:?96 L:L:?97 N:N:?42 N:N:?56 N:N:?67 N:N:?91 N:N:?95 N:N:?121 N:N:?122
Environment DetailsOpen EMBL-EBI Page
CodeGLM
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds

Code55Z
PDB ResiduesW:W:?801
Environment DetailsOpen EMBL-EBI Page
Code55Z
Name5-azanyl-N-tert-butyl-2-methylsulfanyl-4-[3-(2-morpholin-4-ylethanoylamino)phenyl]thieno[2,3-d]pyrimidine-6-carboxamide
Synonyms
Identifier
FormulaC24 H30 N6 O3 S2
Molecular Weight514.663
SMILES
PubChem9914457
Formal Charge0
Total Atoms65
Total Chiral Atoms0
Total Bonds68
Total Aromatic Bonds16

PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP04896
Sequence
>7FIH_Chain_A
?TLSAED?A AVERS?MIE ?QLQ?D?QV ?RATHRLLL L?ADNS??S 
TIV?QMRI? HV?TS?IFE T?FQVD?VN FHMFDV?AQ RDERR?WIQ 
?FNDVTAII FVVDSSD?N RLQEALNDF ?SIWNNRWL RTISVILFL 
N?QDLLAE? VLA??S?IE D?FPEFAR? TTPEDATPE P?EDPRVTR 
A??FIRDEF LRISTAS?D ?RH???PHF T?SVDTENA RRIFND?RD 
IIQRMHLRQ ?ELL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP54311
Sequence
>7FIH_Chain_B
ELDQLRQEA EQL?NQIRD AR?A?ADAT LSQITNNID PV?RIQMRT 
RRTLR?HLA ?I?AMHW?T DSRLLVSAS QD??LIIWD S?TTN?VHA 
IPLRSSWVM T?A?APS?N ?VA???LDN I?SI?NL?T RE?NVRVSR 
ELA?HT??L S??RFLDDN QIVTSS?DT T?ALWDIET ?QQTTTFT? 
HT?DVMSLS LAPDTRLFV S?A?DASA? LWDVRE?M? RQTFT?HES 
DINAI?FFP N?NAFAT?S DDAT?RLFD LRADQELMT ?SHDNII?? 
ITSVSFS?S ?RLLLA??D DFN?NVWDA L?ADRA?VL A?HDNRVS? 
L?VTDD?MA VAT?SWDSF L?IWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP63212
Sequence
>7FIH_Chain_G
TASIAQAR? LVEQL?MEA NIDRI?VS? AAADLMA?? EAHA?EDPL 
LTPVPASEN PFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP22888
Sequence
>7FIH_Chain_R
TRLSLA?LP V?VIPSQAF R?LNEVI?I EISQIDSLE RIEANAFDN 
LLNLSEILI QNT?NLR?I EP?AFINLP RL??LSI?N T?IR?FPDV 
T?VFSSESN FILEI?DNL HITTIP?NA FQ?MNNESV TL?L??N?F 
EEVQSHAFN ?TTLTSLEL ?ENVHLE?M HN?AFR?AT ?P?TLDISS 
T?LQALPS? ?LESIQRLI ATSS?SL?? LPSRETFVN LLEATLT?P 
IH??AFRNL PD?E??F?L P?TPR?APE PDAFNP?ED IM??DFLRV 
LIWLINILA IM?NMTVLF VLLTSR??L TVPRFLM?N LSFADF?M? 
L?LLLIASV DSQT??Q?? NHAIDWQT? S??STA?FF TVFASELSV 
?TLTVITLE RWHTIT?AI HLDQ?LRLR HAILIML?? WLFSSLIAM 
LPLV?VSN? M?VSI?FPM DVETTLSQV ?ILTILILN VVAFFII?A 
??I?I?FAV RNPELMATN ?DT?IA??M AILIFTDFT ?MAPISFFA 
ISAAF?VPL ITVTNS?VL LVLF?PINS ?ANPFL?AI FT?TFQRDF 
FLLLS?F?? ?


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
6ZFZAAmineAcetylcholine (muscarinic)M1Homo sapiens77-LH-28-1--2.172021-10-0610.1016/j.cell.2021.11.001
7FIJAProteinGlycoprotein HormoneLHHomo sapiens---3.82021-09-2910.1038/s41586-021-03924-2
7FIIAProteinGlycoprotein HormoneLHHomo sapienshCG-chim(NtGi1-Gs)/β1/γ24.32021-09-2910.1038/s41586-021-03924-2
7FII (No Gprot) AProteinGlycoprotein HormoneLHHomo sapienshCG-4.32021-09-2910.1038/s41586-021-03924-2
7FIHAProteinGlycoprotein HormoneLHHomo sapienshCGOrg43553chim(NtGi1-Gs)/β1/γ23.22021-09-2910.1038/s41586-021-03924-2
7FIH (No Gprot) AProteinGlycoprotein HormoneLHHomo sapienshCGOrg435533.22021-09-2910.1038/s41586-021-03924-2
7FIGAProteinGlycoprotein HormoneLHHomo sapienshCG-chim(NtGi1L-Gs)/β1/γ23.92021-09-2910.1038/s41586-021-03924-2
7FIG (No Gprot) AProteinGlycoprotein HormoneLHHomo sapienshCG-3.92021-09-2910.1038/s41586-021-03924-2
5OLHANucleotideAdenosineA2AHomo sapiensVipadenantNa-2.62018-01-1710.1038/s41598-017-18570-w
5GLHAPeptideEndothelinETBHomo sapiensEndothelin-1--2.82016-09-0710.1038/nature19319




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Download 7FIH.zip



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