psnGPCR

Code	TMR
Name	2,6-dideoxy-4-S-methyl-4-thio-beta-D-ribo-hexopyranose
Synonyms	2,6-DIDEOXY-4-THIOMETHYL-BETA-D-RIBOHEXOPYRANOSIDE; 2,6-dideoxy-4-S-methyl-4-thio-beta-D-ribo-hexose; 2,6-dideoxy-4-S-methyl-4-thio-D-ribo-hexose; 2,6-dideoxy-4-S-methyl-4-thio-ribo-hexose
Identifier	(2R,4S,5S,6R)-6-methyl-5-methylsulfanyl-oxane-2,4-diol
Formula	C7 H14 O3 S
Molecular Weight	178.249
SMILES	C[C@@H]1[C@H]([C@H](C[C@@H](O1)O)O)SC
PubChem	447846
Formal Charge	0
Total Atoms	25
Total Chiral Atoms	4
Total Bonds	25
Total Aromatic Bonds	0
Networks	2

This ligand is also present in the following 2 networks:

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

7FIG

Protein

Glycoprotein hormone

Homo sapiens

hCG

chim(NtGi1L-Gs)/Beta1/Gamma2

3.9

2021-09-29

10.1038/s41586-021-03924-2

A 2D representation of the interactions of TMR in 7FIG
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
A:A:?34	A:A:?37	7.23	1	Yes	Yes	5	3	1	0
A:A:?34	B:B:L55	5.78	1	Yes	No	5	6	1	1
A:A:?37	A:A:V36	4.35	1	Yes	No	3	2	0	1
A:A:?37	A:A:R38	9.45	1	Yes	No	3	3	0	1
A:A:?37	A:A:T40	7.17	1	Yes	No	3	6	0	1
A:A:?37	A:A:R42	25.99	1	Yes	No	3	9	0	1
A:A:?37	B:B:L55	5.38	1	Yes	No	3	6	0	1
A:A:?37	B:B:A56	6.13	1	Yes	No	3	7	0	1
A:A:H220	A:A:T40	13.69	0	No	No	7	6	2	1
A:A:D240	A:A:R42	7.15	0	No	No	7	9	2	1
B:B:D76	B:B:L55	12.21	1	Yes	No	9	6	2	1
B:B:A56	B:B:D76	4.63	0	No	Yes	7	9	1	2
A:A:?32	A:A:?34	3.45	1	No	Yes	4	5	2	1
A:A:?32	A:A:Q35	2.38	1	No	No	4	4	2	2
A:A:?34	A:A:Q35	2.38	1	Yes	No	5	4	1	2
A:A:N218	A:A:T40	1.46	0	No	No	4	6	2	1

Statistics	Value
Average Number Of Links	7.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	9.39
Average Nodes In Shell	14.00
Average Hubs In Shell	3.00
Average Links In Shell	16.00
Average Links Mediated by Hubs In Shell	12.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TMR in 7FIG
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
A:A:?63	A:A:I62	9.72	Yes	No	9	9	0	1
A:A:?63	A:A:A372	9.19	Yes	No	9	8	0	1
A:A:?63	A:A:T369	2.87	Yes	No	9	9	0	1
A:A:A372	A:A:F212	2.77	No	Yes	8	9	1	2
A:A:N66	A:A:V65	1.48	No	No	4	5	2	1
A:A:?63	A:A:V65	1.45	Yes	No	9	5	0	1

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	5.81
Average Nodes In Shell	7.00
Average Hubs In Shell	2.00
Average Links In Shell	6.00
Average Links Mediated by Hubs In Shell	5.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TMR in 7FIG
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
A:A:?300	A:A:S251	5.37	0	Yes	No	9	9	1	2
A:A:?253	A:A:N264	6.68	19	Yes	No	9	9	0	1
A:A:?253	A:A:L266	5.38	19	Yes	No	9	9	0	1
A:A:?253	A:A:?300	8.83	19	Yes	Yes	9	9	0	1
A:A:?253	A:A:?307	4.82	19	Yes	No	9	5	0	1
A:A:?253	A:A:I308	4.16	19	Yes	No	9	7	0	1
A:A:?253	A:A:?311	13.09	19	Yes	Yes	9	5	0	1
A:A:?311	A:A:N264	20.03	19	Yes	No	5	9	1	1
A:A:L266	A:A:L270	4.15	0	No	No	9	6	1	2
A:A:I341	A:A:L266	8.56	0	No	No	7	9	2	1
A:A:?305	A:A:?307	5.42	0	No	No	3	5	2	1
A:A:?307	A:A:?311	18.47	19	No	Yes	5	5	1	1
A:A:F315	A:A:I308	12.56	0	No	No	6	7	2	1
A:A:?311	A:A:D310	6.6	19	Yes	No	5	3	1	2
A:A:?311	A:A:F312	21.32	19	Yes	No	5	8	1	2
A:A:?311	A:A:P313	3.19	19	Yes	No	5	6	1	2
A:A:?300	A:A:A303	2.82	0	Yes	No	9	4	1	2
A:A:?300	A:A:E299	0.79	0	Yes	No	9	5	1	2

Statistics	Value
Average Number Of Links	6.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	7.16
Average Nodes In Shell	17.00
Average Hubs In Shell	3.00
Average Links In Shell	18.00
Average Links Mediated by Hubs In Shell	14.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TMR in 7FIG
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
A:A:?253	A:A:N264	6.68	19	Yes	No	9	9	1	1
A:A:?253	A:A:L266	5.38	19	Yes	No	9	9	1	2
A:A:?253	A:A:?300	8.83	19	Yes	Yes	9	9	1	2
A:A:?253	A:A:?307	4.82	19	Yes	No	9	5	1	1
A:A:?253	A:A:I308	4.16	19	Yes	No	9	7	1	2
A:A:?253	A:A:?311	13.09	19	Yes	Yes	9	5	1	0
A:A:?311	A:A:N264	20.03	19	Yes	No	5	9	0	1
A:A:F312	A:A:Q267	5.86	0	No	No	8	4	1	2
A:A:?305	A:A:?307	5.42	0	No	No	3	5	2	1
A:A:?307	A:A:?311	18.47	19	No	Yes	5	5	1	0
A:A:?311	A:A:D310	6.6	19	Yes	No	5	3	0	1
A:A:?311	A:A:F312	21.32	19	Yes	No	5	8	0	1
A:A:F312	A:A:F340	7.5	0	No	Yes	8	6	1	2
A:A:?311	A:A:P313	3.19	19	Yes	No	5	6	0	1

Statistics	Value
Average Number Of Links	6.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	13.78
Average Nodes In Shell	13.00
Average Hubs In Shell	4.00
Average Links In Shell	14.00
Average Links Mediated by Hubs In Shell	12.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TMR in 7FIG
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
A:A:F312	A:A:F340	7.5	0	No	Yes	8	6	2	1
A:A:E314	A:A:R317	12.79	0	No	No	5	2	2	1
A:A:F315	A:A:R336	19.24	0	No	No	6	5	2	1
A:A:F315	A:A:F340	4.29	0	No	Yes	6	6	2	1
A:A:?318	A:A:T319	8.6	3	Yes	No	7	2	0	1
A:A:?318	A:A:P321	11.18	3	Yes	No	7	4	0	1
A:A:?318	A:A:R336	15.36	3	Yes	No	7	5	0	1
A:A:?318	A:A:?339	11.78	3	Yes	Yes	7	3	0	1
A:A:?318	A:A:F340	16.58	3	Yes	Yes	7	6	0	1
A:A:?318	A:A:D343	15.84	3	Yes	No	7	3	0	1
A:A:R336	A:A:T319	6.47	3	No	No	5	2	1	1
A:A:?339	A:A:A324	9.19	3	Yes	No	3	3	1	2
A:A:?338	A:A:?339	21.68	3	Yes	Yes	5	3	2	1
A:A:?338	A:A:F363	6.54	3	Yes	Yes	5	5	2	2
A:A:?339	A:A:R342	7.09	3	Yes	Yes	3	5	1	2
A:A:?339	A:A:D343	9.24	3	Yes	No	3	3	1	1
A:A:?339	A:A:F363	4.74	3	Yes	Yes	3	5	1	2
A:A:E344	A:A:F340	4.66	0	No	Yes	6	6	2	1
A:A:D343	A:A:R342	9.53	3	No	Yes	3	5	1	2
A:A:F363	A:A:R342	7.48	3	Yes	Yes	5	5	2	2
A:A:?318	A:A:R317	2.36	3	Yes	No	7	2	0	1

Statistics	Value
Average Number Of Links	7.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	11.67
Average Nodes In Shell	16.00
Average Hubs In Shell	6.00
Average Links In Shell	21.00
Average Links Mediated by Hubs In Shell	18.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TMR in 7FIG
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
A:A:?338	A:A:Q294	6.35	3	Yes	Yes	5	6	1	2
A:A:F363	A:A:Q294	12.88	3	Yes	Yes	5	6	1	2
A:A:?318	A:A:T319	8.6	3	Yes	No	7	2	1	2
A:A:?318	A:A:P321	11.18	3	Yes	No	7	4	1	2
A:A:?318	A:A:R336	15.36	3	Yes	No	7	5	1	2
A:A:?318	A:A:?339	11.78	3	Yes	Yes	7	3	1	0
A:A:?318	A:A:F340	16.58	3	Yes	Yes	7	6	1	2
A:A:?318	A:A:D343	15.84	3	Yes	No	7	3	1	1
A:A:R336	A:A:T319	6.47	3	No	No	5	2	2	2
A:A:D323	A:A:R342	4.76	0	No	Yes	3	5	2	1
A:A:?339	A:A:A324	9.19	3	Yes	No	3	3	0	1
A:A:?338	A:A:E330	5.53	3	Yes	Yes	5	3	1	2
A:A:?338	A:A:?339	21.68	3	Yes	Yes	5	3	1	0
A:A:?338	A:A:F363	6.54	3	Yes	Yes	5	5	1	1
A:A:?339	A:A:R342	7.09	3	Yes	Yes	3	5	0	1
A:A:?339	A:A:D343	9.24	3	Yes	No	3	3	0	1
A:A:?339	A:A:F363	4.74	3	Yes	Yes	3	5	0	1
A:A:D343	A:A:R342	9.53	3	No	Yes	3	5	1	1
A:A:L346	A:A:R342	10.93	3	No	Yes	3	5	2	1
A:A:P361	A:A:R342	7.21	3	No	Yes	4	5	2	1
A:A:F363	A:A:R342	7.48	3	Yes	Yes	5	5	1	1
A:A:L346	A:A:P361	6.57	3	No	No	3	4	2	2
A:A:?318	A:A:R317	2.36	3	Yes	No	7	2	1	2
A:A:?338	A:A:A337	1.88	3	Yes	No	5	7	1	2

Statistics	Value
Average Number Of Links	6.00
Average Number Of Links With An Hub	4.00
Average Interaction Strength	10.62
Average Nodes In Shell	18.00
Average Hubs In Shell	8.00
Average Links In Shell	24.00
Average Links Mediated by Hubs In Shell	22.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TMR in 7FIG
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
A:A:N278	A:A:W277	4.52	0	No	Yes	8	6	2	1
A:A:V287	A:A:W277	4.9	0	No	Yes	5	6	2	1
A:A:S349	A:A:W277	4.94	3	No	Yes	8	6	2	1
A:A:H357	A:A:W277	29.62	3	No	Yes	7	6	1	1
A:A:?358	A:A:W277	6.65	3	Yes	Yes	4	6	0	1
A:A:?359	A:A:W277	7.32	3	Yes	Yes	6	6	1	1
A:A:?358	A:A:S286	11.68	3	Yes	No	4	8	0	1
A:A:?360	A:A:S286	5.84	3	Yes	No	8	8	1	1
A:A:I382	A:A:S286	9.29	3	Yes	No	7	8	2	1
A:A:?360	A:A:L289	5.38	3	Yes	No	8	9	1	2
A:A:?359	A:A:S349	4.82	3	Yes	No	6	8	1	2
A:A:?353	A:A:H357	7.85	0	No	No	2	7	2	1
A:A:?358	A:A:D354	7.92	3	Yes	No	4	3	0	1
A:A:?358	A:A:H357	5	3	Yes	No	4	7	0	1
A:A:?358	A:A:?359	21.62	3	Yes	Yes	4	6	0	1
A:A:?358	A:A:?360	17.02	3	Yes	Yes	4	8	0	1
A:A:?358	A:A:R385	11.82	3	Yes	No	4	6	0	1
A:A:?359	A:A:?360	40.37	3	Yes	Yes	6	8	1	1
A:A:?360	A:A:P361	14.37	3	Yes	No	8	4	1	2
A:A:?360	A:A:D378	15.84	3	Yes	No	8	7	1	2
A:A:?360	A:A:D381	11.88	3	Yes	No	8	8	1	2
A:A:?360	A:A:I382	8.33	3	Yes	Yes	8	7	1	2
A:A:D381	A:A:R385	13.1	3	No	No	8	6	2	1
A:A:D381	R:R:N555	5.39	3	No	Yes	8	7	2	2
A:A:R385	R:R:N555	13.26	3	No	Yes	6	7	1	2
A:A:?358	R:R:A560	3.06	3	Yes	No	4	3	0	1

Statistics	Value
Average Number Of Links	8.00
Average Number Of Links With An Hub	3.00
Average Interaction Strength	10.60
Average Nodes In Shell	19.00
Average Hubs In Shell	6.00
Average Links In Shell	26.00
Average Links Mediated by Hubs In Shell	24.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TMR in 7FIG
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
A:A:F273	A:A:L289	9.74	3	Yes	No	9	9	2	1
A:A:F273	A:A:F345	4.29	3	Yes	Yes	9	8	2	2
A:A:S349	A:A:W277	4.94	3	No	Yes	8	6	2	2
A:A:H357	A:A:W277	29.62	3	No	Yes	7	6	2	2
A:A:?358	A:A:W277	6.65	3	Yes	Yes	4	6	1	2
A:A:?359	A:A:W277	7.32	3	Yes	Yes	6	6	1	2
A:A:?358	A:A:S286	11.68	3	Yes	No	4	8	1	1
A:A:?360	A:A:S286	5.84	3	Yes	No	8	8	0	1
A:A:I382	A:A:S286	9.29	3	Yes	No	7	8	1	1
A:A:F345	A:A:L289	6.09	3	Yes	No	8	9	2	1
A:A:?360	A:A:L289	5.38	3	Yes	No	8	9	0	1
A:A:L346	A:A:R342	10.93	3	No	Yes	3	5	2	2
A:A:P361	A:A:R342	7.21	3	No	Yes	4	5	1	2
A:A:L346	A:A:P361	6.57	3	No	No	3	4	2	1
A:A:?359	A:A:S349	4.82	3	Yes	No	6	8	1	2
A:A:?358	A:A:D354	7.92	3	Yes	No	4	3	1	2
A:A:?358	A:A:H357	5	3	Yes	No	4	7	1	2
A:A:?358	A:A:?359	21.62	3	Yes	Yes	4	6	1	1
A:A:?358	A:A:?360	17.02	3	Yes	Yes	4	8	1	0
A:A:?358	A:A:R385	11.82	3	Yes	No	4	6	1	2
A:A:?359	A:A:?360	40.37	3	Yes	Yes	6	8	1	0
A:A:?360	A:A:P361	14.37	3	Yes	No	8	4	0	1
A:A:?360	A:A:D378	15.84	3	Yes	No	8	7	0	1
A:A:?360	A:A:D381	11.88	3	Yes	No	8	8	0	1
A:A:?360	A:A:I382	8.33	3	Yes	Yes	8	7	0	1
A:A:D378	A:A:H362	12.61	0	No	No	7	9	1	2
A:A:?379	A:A:I382	6.11	3	Yes	Yes	9	7	2	1
A:A:D381	A:A:R385	13.1	3	No	No	8	6	1	2
A:A:D381	R:R:N555	5.39	3	No	Yes	8	7	1	2
A:A:R385	R:R:N555	13.26	3	No	Yes	6	7	2	2
A:A:?358	R:R:A560	3.06	3	Yes	No	4	3	1	2
A:A:I288	A:A:I382	2.94	0	No	Yes	9	7	2	1
A:A:D378	R:R:L558	2.71	0	No	No	7	4	1	2
A:A:A243	A:A:I382	1.62	0	No	Yes	8	7	2	1

Statistics	Value
Average Number Of Links	8.00
Average Number Of Links With An Hub	3.00
Average Interaction Strength	14.88
Average Nodes In Shell	25.00
Average Hubs In Shell	10.00
Average Links In Shell	34.00
Average Links Mediated by Hubs In Shell	30.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TMR in 7FIG
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
A:A:H387	A:A:Q390	6.18	0	No	No	8	5	2	1
A:A:L388	A:A:L393	5.54	0	No	No	8	9	2	1
A:A:?391	A:A:Q390	6.47	6	Yes	No	4	5	0	1
A:A:?391	A:A:L393	9.42	6	Yes	No	4	9	0	1
A:A:?391	R:R:E463	10.31	6	Yes	No	4	9	0	1
A:A:?391	R:R:R464	16.54	6	Yes	Yes	4	8	0	1
A:A:?391	R:R:T467	7.17	6	Yes	No	4	8	0	1
A:A:E392	R:R:?628	7.11	0	No	No	6	7	1	2
R:R:I460	R:R:R464	5.01	6	No	Yes	9	8	2	1
R:R:?623	R:R:I460	4.16	6	Yes	No	9	9	2	2
R:R:E463	R:R:T467	8.47	6	No	No	9	8	1	1
R:R:?546	R:R:R464	9.45	6	Yes	Yes	9	8	2	1
R:R:?623	R:R:R464	8.27	6	Yes	Yes	9	8	2	1
A:A:?391	A:A:E392	3.87	6	Yes	No	4	6	0	1

Statistics	Value
Average Number Of Links	6.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	8.96
Average Nodes In Shell	13.00
Average Hubs In Shell	4.00
Average Links In Shell	14.00
Average Links Mediated by Hubs In Shell	10.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TMR in 7FIG
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
A:A:?237	B:B:?59	7.21	1	Yes	Yes	8	8	1	0
A:A:?237	B:B:Q75	17.1	1	Yes	Yes	8	9	1	1
A:A:?237	B:B:W99	7.32	1	Yes	Yes	8	9	1	2
A:A:?237	B:B:M101	4.54	1	Yes	Yes	8	9	1	1
A:A:?237	B:B:L117	7.41	1	Yes	Yes	8	9	1	2
A:A:N239	B:B:W332	6.78	0	No	Yes	8	9	2	1
A:A:W281	B:B:R314	9	1	Yes	Yes	5	8	2	2
A:A:W281	B:B:W332	7.5	1	Yes	Yes	5	9	2	1
B:B:H54	B:B:I58	13.26	1	Yes	Yes	9	9	2	1
B:B:H54	B:B:S72	5.58	1	Yes	No	9	9	2	2
B:B:?57	B:B:Q75	7.15	0	No	Yes	9	9	2	1
B:B:?59	B:B:I58	5.55	1	Yes	Yes	8	9	0	1
B:B:I58	B:B:S72	4.64	1	Yes	No	9	9	1	2
B:B:I58	B:B:L336	4.28	1	Yes	No	9	7	1	2
B:B:?59	B:B:Q75	19.42	1	Yes	Yes	8	9	0	1
B:B:?59	B:B:M101	5.5	1	Yes	Yes	8	9	0	1
B:B:?59	B:B:S316	20.45	1	Yes	No	8	9	0	1
B:B:?317	B:B:?59	7.21	1	Yes	Yes	7	8	1	0
B:B:?59	B:B:W332	7.75	1	Yes	Yes	8	9	0	1
B:B:?317	B:B:M61	4.54	1	Yes	Yes	7	6	1	2
B:B:Q75	B:B:W99	9.86	1	Yes	Yes	9	9	1	2
B:B:L117	B:B:M101	5.65	1	Yes	Yes	9	9	2	1
B:B:?145	B:B:M101	5.5	1	Yes	Yes	8	9	2	1
B:B:?145	B:B:L117	5.38	1	Yes	Yes	8	9	2	2
B:B:?317	B:B:S275	6.43	1	Yes	No	7	8	1	2
B:B:N313	B:B:W332	6.78	0	No	Yes	7	9	2	1
B:B:R314	B:B:W332	20.99	1	Yes	Yes	8	9	2	1
B:B:?317	B:B:V315	4.79	1	Yes	No	7	7	1	2
B:B:?317	B:B:S316	4.82	1	Yes	No	7	9	1	1
B:B:S316	B:B:W332	6.18	1	No	Yes	9	9	1	1
B:B:?317	B:B:?330	18.1	1	Yes	No	7	5	1	2

Statistics	Value
Average Number Of Links	7.00
Average Number Of Links With An Hub	6.00
Average Interaction Strength	10.44
Average Nodes In Shell	23.00
Average Hubs In Shell	14.00
Average Links In Shell	31.00
Average Links Mediated by Hubs In Shell	31.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TMR in 7FIG
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
B:B:?85	B:B:R49	4.73	20	Yes	Yes	4	7	0	1
B:B:I338	B:B:R49	6.26	0	No	Yes	5	7	2	1
B:B:R49	G:G:F61	8.55	0	Yes	Yes	7	8	1	2
B:B:D83	B:B:R68	17.87	20	No	No	8	5	1	1
B:B:?85	B:B:R68	27.18	20	Yes	No	4	5	0	1
B:B:?85	B:B:D83	23.76	20	Yes	No	4	8	0	1
B:B:D83	B:B:T86	11.56	20	No	No	8	6	1	1
B:B:?85	B:B:S84	10.22	20	Yes	No	4	5	0	1
B:B:S84	G:G:F61	5.28	0	No	Yes	5	8	1	2
B:B:?85	B:B:T86	8.6	20	Yes	No	4	6	0	1
B:B:?85	G:G:P60	11.18	20	Yes	No	4	9	0	1
B:B:N88	B:B:T86	14.62	0	Yes	No	7	6	2	1
G:G:N59	G:G:P60	6.52	0	Yes	No	9	9	2	1
G:G:F61	G:G:N59	8.46	0	Yes	Yes	8	9	2	2
B:B:R49	G:G:R62	1.07	0	Yes	No	7	7	1	2

Statistics	Value
Average Number Of Links	6.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	14.28
Average Nodes In Shell	12.00
Average Hubs In Shell	5.00
Average Links In Shell	15.00
Average Links Mediated by Hubs In Shell	13.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TMR in 7FIG
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
B:B:?105	B:B:H62	11.25	5	Yes	No	6	6	0	1
B:B:H62	B:B:R150	6.77	0	No	No	6	6	1	2
B:B:?64	B:B:W63	4.97	0	No	Yes	5	7	1	2
B:B:?105	B:B:?64	9.39	5	Yes	No	6	5	0	1
B:B:D66	B:B:L69	6.79	0	No	No	8	5	2	1
B:B:?105	B:B:L69	8.08	5	Yes	No	6	5	0	1
B:B:L79	B:B:V71	5.96	0	Yes	No	7	8	2	1
B:B:?103	B:B:V71	4.79	0	Yes	No	8	8	2	1
B:B:?105	B:B:V71	10.14	5	Yes	No	6	8	0	1
B:B:L79	B:B:V112	4.47	0	Yes	Yes	7	8	2	1
B:B:H91	B:B:I81	7.95	0	No	No	5	7	2	1
B:B:?105	B:B:I81	5.55	5	Yes	No	6	7	0	1
B:B:I81	B:B:L126	4.28	0	No	No	7	5	1	2
B:B:?105	B:B:?109	10.57	5	Yes	Yes	6	5	0	1
B:B:?105	B:B:?111	7.86	5	Yes	Yes	6	4	0	1
B:B:?105	B:B:V112	5.8	5	Yes	Yes	6	8	0	1
B:B:?105	B:B:F151	13.03	5	Yes	Yes	6	9	0	1
B:B:?111	B:B:A106	9.19	5	Yes	No	4	6	1	2
B:B:A106	B:B:F151	9.71	5	No	Yes	6	9	2	1
B:B:?109	B:B:S108	6.55	5	Yes	No	5	6	1	2
B:B:N110	B:B:S108	11.92	5	Yes	No	4	6	2	2
B:B:D154	B:B:S108	8.83	5	Yes	No	6	6	2	2
B:B:?109	B:B:N110	4.79	5	Yes	Yes	5	4	1	2
B:B:?109	B:B:?111	4.7	5	Yes	Yes	5	4	1	1
B:B:?111	B:B:N110	6.68	5	Yes	Yes	4	4	1	2
B:B:D154	B:B:N110	8.08	5	Yes	Yes	6	4	2	2
B:B:?111	B:B:V112	7.24	5	Yes	Yes	4	8	1	1
B:B:?111	B:B:I123	4.16	5	Yes	Yes	4	6	1	2
B:B:?111	B:B:?124	14.4	5	Yes	Yes	4	6	1	2
B:B:?111	B:B:N125	10.68	5	Yes	No	4	4	1	2
B:B:?111	B:B:F151	7.11	5	Yes	Yes	4	9	1	1
B:B:?111	B:B:D154	7.92	5	Yes	Yes	4	6	1	2
B:B:?124	B:B:V112	5.8	5	Yes	Yes	6	8	2	1
B:B:L126	B:B:V112	5.96	0	No	Yes	5	8	2	1
B:B:?124	B:B:I123	6.94	5	Yes	Yes	6	6	2	2
B:B:F151	B:B:I123	5.02	5	Yes	Yes	9	6	1	2
B:B:F151	B:B:I157	5.02	5	Yes	No	9	7	1	2
B:B:?64	B:B:T65	3.86	0	No	No	5	1	1	2
B:B:?111	B:B:S136	2.92	5	Yes	No	4	4	1	2

Statistics	Value
Average Number Of Links	9.00
Average Number Of Links With An Hub	4.00
Average Interaction Strength	9.07
Average Nodes In Shell	27.00
Average Hubs In Shell	12.00
Average Links In Shell	39.00
Average Links Mediated by Hubs In Shell	34.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TMR in 7FIG
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
B:B:?105	B:B:H62	11.25	5	Yes	No	6	6	1	2
B:B:?105	B:B:?64	9.39	5	Yes	No	6	5	1	2
B:B:?105	B:B:L69	8.08	5	Yes	No	6	5	1	2
B:B:L79	B:B:V71	5.96	0	Yes	No	7	8	2	2
B:B:?105	B:B:V71	10.14	5	Yes	No	6	8	1	2
B:B:I93	B:B:L79	4.28	5	Yes	Yes	7	7	2	2
B:B:L79	B:B:L95	4.15	0	Yes	Yes	7	8	2	2
B:B:L79	B:B:V112	4.47	0	Yes	Yes	7	8	2	1
B:B:?105	B:B:I81	5.55	5	Yes	No	6	7	1	2
B:B:I81	B:B:L126	4.28	0	No	No	7	5	2	2
B:B:?124	B:B:I93	5.55	5	Yes	Yes	6	7	1	2
B:B:I93	B:B:V133	6.14	5	Yes	No	7	4	2	2
B:B:?124	B:B:L95	6.73	5	Yes	Yes	6	8	1	2
B:B:?105	B:B:?109	10.57	5	Yes	Yes	6	5	1	1
B:B:?105	B:B:?111	7.86	5	Yes	Yes	6	4	1	0
B:B:?105	B:B:V112	5.8	5	Yes	Yes	6	8	1	1
B:B:?105	B:B:F151	13.03	5	Yes	Yes	6	9	1	1
B:B:?111	B:B:A106	9.19	5	Yes	No	4	6	0	1
B:B:A106	B:B:F151	9.71	5	No	Yes	6	9	1	1
B:B:?109	B:B:S108	6.55	5	Yes	No	5	6	1	2
B:B:N110	B:B:S108	11.92	5	Yes	No	4	6	1	2
B:B:D154	B:B:S108	8.83	5	Yes	No	6	6	1	2
B:B:?109	B:B:N110	4.79	5	Yes	Yes	5	4	1	1
B:B:?109	B:B:?111	4.7	5	Yes	Yes	5	4	1	0
B:B:?111	B:B:N110	6.68	5	Yes	Yes	4	4	0	1
B:B:D154	B:B:N110	8.08	5	Yes	Yes	6	4	1	1
B:B:?111	B:B:V112	7.24	5	Yes	Yes	4	8	0	1
B:B:?111	B:B:I123	4.16	5	Yes	Yes	4	6	0	1
B:B:?111	B:B:?124	14.4	5	Yes	Yes	4	6	0	1
B:B:?111	B:B:N125	10.68	5	Yes	No	4	4	0	1
B:B:?111	B:B:F151	7.11	5	Yes	Yes	4	9	0	1
B:B:?111	B:B:D154	7.92	5	Yes	Yes	4	6	0	1
B:B:?124	B:B:V112	5.8	5	Yes	Yes	6	8	1	1
B:B:L126	B:B:V112	5.96	0	No	Yes	5	8	2	1
B:B:?124	B:B:S122	10.22	5	Yes	No	6	8	1	2
B:B:?124	B:B:I123	6.94	5	Yes	Yes	6	6	1	1
B:B:I123	B:B:L139	4.28	5	Yes	Yes	6	9	1	2
B:B:F151	B:B:I123	5.02	5	Yes	Yes	9	6	1	1
B:B:?124	B:B:V133	4.35	5	Yes	No	6	4	1	2
B:B:?124	B:B:V135	8.69	5	Yes	No	6	4	1	2
B:B:?127	B:B:N125	12.29	0	No	No	4	4	2	1
B:B:F151	B:B:I157	5.02	5	Yes	No	9	7	1	2
B:B:D153	B:B:D154	3.99	0	No	Yes	5	6	2	1
B:B:D154	B:B:P107	3.22	5	Yes	No	6	6	1	2
B:B:?111	B:B:S136	2.92	5	Yes	No	4	4	0	1

Statistics	Value
Average Number Of Links	11.00
Average Number Of Links With An Hub	8.00
Average Interaction Strength	7.53
Average Nodes In Shell	30.00
Average Hubs In Shell	13.00
Average Links In Shell	45.00
Average Links Mediated by Hubs In Shell	43.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TMR in 7FIG
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
B:B:?77	B:B:L95	9.66	1	Yes	Yes	8	8	2	1
B:B:I93	B:B:L79	4.28	5	Yes	Yes	7	7	1	2
B:B:L79	B:B:L95	4.15	0	Yes	Yes	7	8	2	1
B:B:L79	B:B:V112	4.47	0	Yes	Yes	7	8	2	1
B:B:?124	B:B:I93	5.55	5	Yes	Yes	6	7	0	1
B:B:I93	B:B:V133	6.14	5	Yes	No	7	4	1	1
B:B:?114	B:B:L95	4.45	5	Yes	Yes	8	8	2	1
B:B:?124	B:B:L95	6.73	5	Yes	Yes	6	8	0	1
B:B:?105	B:B:?109	10.57	5	Yes	Yes	6	5	2	2
B:B:?105	B:B:?111	7.86	5	Yes	Yes	6	4	2	1
B:B:?105	B:B:V112	5.8	5	Yes	Yes	6	8	2	1
B:B:?105	B:B:F151	13.03	5	Yes	Yes	6	9	2	2
B:B:?111	B:B:A106	9.19	5	Yes	No	4	6	1	2
B:B:A106	B:B:F151	9.71	5	No	Yes	6	9	2	2
B:B:?109	B:B:N110	4.79	5	Yes	Yes	5	4	2	2
B:B:?109	B:B:?111	4.7	5	Yes	Yes	5	4	2	1
B:B:?111	B:B:N110	6.68	5	Yes	Yes	4	4	1	2
B:B:D154	B:B:N110	8.08	5	Yes	Yes	6	4	2	2
B:B:?111	B:B:V112	7.24	5	Yes	Yes	4	8	1	1
B:B:?111	B:B:I123	4.16	5	Yes	Yes	4	6	1	1
B:B:?111	B:B:?124	14.4	5	Yes	Yes	4	6	1	0
B:B:?111	B:B:N125	10.68	5	Yes	No	4	4	1	2
B:B:?111	B:B:F151	7.11	5	Yes	Yes	4	9	1	2
B:B:?111	B:B:D154	7.92	5	Yes	Yes	4	6	1	2
B:B:?124	B:B:V112	5.8	5	Yes	Yes	6	8	0	1
B:B:L126	B:B:V112	5.96	0	No	Yes	5	8	2	1
B:B:?114	B:B:?121	6.35	5	Yes	Yes	8	8	2	2
B:B:?114	B:B:S122	8.04	5	Yes	No	8	8	2	1
B:B:?121	B:B:S122	6.43	5	Yes	No	8	8	2	1
B:B:?124	B:B:S122	10.22	5	Yes	No	6	8	0	1
B:B:?124	B:B:I123	6.94	5	Yes	Yes	6	6	0	1
B:B:I123	B:B:L139	4.28	5	Yes	Yes	6	9	1	2
B:B:F151	B:B:I123	5.02	5	Yes	Yes	9	6	2	1
B:B:?124	B:B:V133	4.35	5	Yes	No	6	4	0	1
B:B:?124	B:B:V135	8.69	5	Yes	No	6	4	0	1
B:B:I93	B:B:P94	3.39	5	Yes	No	7	5	1	2
B:B:?111	B:B:S136	2.92	5	Yes	No	4	4	1	2

Statistics	Value
Average Number Of Links	8.00
Average Number Of Links With An Hub	5.00
Average Interaction Strength	7.83
Average Nodes In Shell	24.00
Average Hubs In Shell	16.00
Average Links In Shell	37.00
Average Links Mediated by Hubs In Shell	37.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TMR in 7FIG
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
A:A:V224	A:A:W234	13.48	0	No	Yes	9	9	2	1
A:A:?225	A:A:Q227	4.64	0	No	Yes	9	9	2	1
A:A:Q227	B:B:N119	6.6	1	Yes	No	9	9	1	1
A:A:Q227	B:B:?144	6.96	1	Yes	Yes	9	8	1	1
A:A:Q227	B:B:?145	15.53	1	Yes	Yes	9	8	1	0
A:A:R228	B:B:?162	7.42	1	Yes	Yes	9	9	2	1
A:A:R228	B:B:?185	8.48	1	Yes	Yes	9	5	2	2
A:A:R228	B:B:D186	4.76	1	Yes	Yes	9	9	2	1
A:A:R231	A:A:W234	8	0	No	Yes	9	9	2	1
A:A:I235	A:A:W234	8.22	0	No	Yes	9	9	2	1
A:A:W234	B:B:?145	4.43	0	Yes	Yes	9	8	1	0
A:A:?237	B:B:?59	7.21	1	Yes	Yes	8	8	2	2
A:A:?237	B:B:M101	4.54	1	Yes	Yes	8	9	2	1
A:A:?237	B:B:L117	7.41	1	Yes	Yes	8	9	2	1
B:B:?59	B:B:M101	5.5	1	Yes	Yes	8	9	2	1
B:B:L117	B:B:M101	5.65	1	Yes	Yes	9	9	1	1
B:B:?145	B:B:M101	5.5	1	Yes	Yes	8	9	0	1
B:B:?115	B:B:?116	10.53	0	No	No	9	9	2	1
B:B:?116	B:B:L117	4.83	1	No	Yes	9	9	1	1
B:B:?116	B:B:?145	5.87	1	No	Yes	9	8	1	0
B:B:?145	B:B:L117	5.38	1	Yes	Yes	8	9	0	1
B:B:?144	B:B:N119	16.76	1	Yes	No	8	9	1	1
B:B:?145	B:B:N119	8.01	1	Yes	No	8	9	0	1
B:B:H142	B:B:S161	12.55	1	Yes	Yes	9	9	2	1
B:B:D163	B:B:H142	11.35	1	Yes	Yes	9	9	2	2
B:B:?144	B:B:?145	18.78	1	Yes	Yes	8	8	1	0
B:B:?144	B:B:S161	6.55	1	Yes	Yes	8	9	1	1
B:B:?144	B:B:D163	8.28	1	Yes	Yes	8	9	1	2
B:B:?145	B:B:S147	8.76	1	Yes	No	8	9	0	1
B:B:?145	B:B:S161	5.84	1	Yes	Yes	8	9	0	1
B:B:?145	B:B:?162	16.44	1	Yes	Yes	8	9	0	1
B:B:?145	B:B:D186	13.2	1	Yes	Yes	8	9	0	1
B:B:M188	B:B:S147	4.6	0	No	No	8	9	2	1
B:B:?162	B:B:S161	7.86	1	Yes	Yes	9	9	1	1
B:B:D163	B:B:S161	11.78	1	Yes	Yes	9	9	2	1
B:B:?162	B:B:D163	4.73	1	Yes	Yes	9	9	1	2
B:B:?162	B:B:D186	11.84	1	Yes	Yes	9	9	1	1
B:B:?185	B:B:D186	5.92	1	Yes	Yes	5	9	2	1
B:B:?204	B:B:D186	5.81	1	Yes	Yes	7	9	2	1
B:B:?204	B:B:M188	6.06	1	Yes	No	7	8	2	2

Statistics	Value
Average Number Of Links	11.00
Average Number Of Links With An Hub	8.00
Average Interaction Strength	9.79
Average Nodes In Shell	25.00
Average Hubs In Shell	16.00
Average Links In Shell	40.00
Average Links Mediated by Hubs In Shell	38.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TMR in 7FIG
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
B:B:L30	B:B:M262	7.07	0	No	No	5	4	2	1
B:B:?250	B:B:T249	12.63	1	Yes	No	8	6	1	2
B:B:R251	B:B:T249	9.06	1	Yes	No	8	6	2	2
B:B:?250	B:B:R251	6.5	1	Yes	Yes	8	8	1	2
B:B:?250	B:B:?264	28.83	1	Yes	Yes	8	5	1	0
B:B:?250	B:B:I273	6.11	1	Yes	Yes	8	6	1	2
B:B:E260	B:B:R251	20.93	0	No	Yes	6	8	2	2
B:B:E260	B:B:T263	9.88	0	No	No	6	1	2	1
B:B:?264	B:B:M262	19.25	0	Yes	No	5	4	0	1
B:B:A302	B:B:M262	4.83	0	No	No	2	4	2	1
B:B:?264	B:B:T263	8.6	0	Yes	No	5	1	0	1
B:B:?264	B:B:S265	7.3	0	Yes	No	5	2	0	1
B:B:?264	B:B:W297	22.15	0	Yes	Yes	5	8	0	1
B:B:H266	B:B:W297	8.46	1	No	Yes	4	8	2	1
B:B:H266	B:B:R304	5.64	1	No	Yes	4	5	2	2
B:B:?289	B:B:I273	12.49	1	Yes	Yes	7	6	2	2
B:B:?289	B:B:W297	5.54	1	Yes	Yes	7	8	2	1
B:B:R304	B:B:W297	6	1	Yes	Yes	5	8	2	1
B:B:?264	B:B:L252	4.04	0	Yes	No	5	7	0	1
B:B:A240	B:B:L252	3.15	0	No	No	6	7	2	1

Statistics	Value
Average Number Of Links	6.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	15.03
Average Nodes In Shell	17.00
Average Hubs In Shell	7.00
Average Links In Shell	20.00
Average Links Mediated by Hubs In Shell	16.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TMR in 7FIG
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
A:A:W281	B:B:D290	8.93	1	Yes	Yes	5	6	2	1
A:A:W281	B:B:R314	9	1	Yes	Yes	5	8	2	2
B:B:?244	B:B:I273	7.47	0	No	Yes	5	6	2	1
B:B:?271	B:B:A248	5.06	1	Yes	No	5	5	1	2
B:B:?250	B:B:?264	28.83	1	Yes	Yes	8	5	2	2
B:B:?250	B:B:I273	6.11	1	Yes	Yes	8	6	2	1
B:B:?264	B:B:W297	22.15	0	Yes	Yes	5	8	2	1
B:B:H266	B:B:I269	5.3	1	No	Yes	4	4	2	1
B:B:H266	B:B:W297	8.46	1	No	Yes	4	8	2	1
B:B:H266	B:B:R304	5.64	1	No	Yes	4	5	2	2
B:B:?289	B:B:I269	4.16	1	Yes	Yes	7	4	0	1
B:B:I269	B:B:N295	4.25	1	Yes	Yes	4	6	1	1
B:B:?271	B:B:?272	20.68	1	Yes	No	5	4	1	1
B:B:?271	B:B:?289	11.53	1	Yes	Yes	5	7	1	0
B:B:?271	B:B:D290	8.72	1	Yes	Yes	5	6	1	1
B:B:?272	B:B:?289	7.04	1	No	Yes	4	7	1	0
B:B:?272	B:B:D290	10.65	1	No	Yes	4	6	1	1
B:B:A287	B:B:I273	4.87	1	No	Yes	6	6	1	1
B:B:?289	B:B:I273	12.49	1	Yes	Yes	7	6	0	1
B:B:?288	B:B:T274	6.43	1	No	No	7	8	1	1
B:B:?289	B:B:T274	8.6	1	Yes	No	7	8	0	1
B:B:R314	B:B:T274	11.64	1	Yes	No	8	8	2	1
B:B:?289	B:B:A287	6.13	1	Yes	No	7	6	0	1
B:B:?288	B:B:?289	27	1	No	Yes	7	7	1	0
B:B:?288	B:B:V315	5.2	1	No	No	7	7	1	2
B:B:?289	B:B:D290	6.6	1	Yes	Yes	7	6	0	1
B:B:?289	B:B:N295	18.7	1	Yes	Yes	7	6	0	1
B:B:?289	B:B:W297	5.54	1	Yes	Yes	7	8	0	1
B:B:D290	B:B:R314	8.34	1	Yes	Yes	6	8	1	2
B:B:?294	B:B:N295	11.76	1	Yes	Yes	5	6	2	1
B:B:N295	B:B:R304	12.05	1	Yes	Yes	6	5	1	2
B:B:R304	B:B:W297	6	1	Yes	Yes	5	8	2	1
B:B:?271	B:B:I270	3.06	1	Yes	No	5	3	1	2
B:B:I269	B:B:N268	2.83	1	Yes	No	4	4	1	2

Statistics	Value
Average Number Of Links	10.00
Average Number Of Links With An Hub	6.00
Average Interaction Strength	10.78
Average Nodes In Shell	23.00
Average Hubs In Shell	13.00
Average Links In Shell	34.00
Average Links Mediated by Hubs In Shell	32.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TMR in 7FIG
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
B:B:F235	B:B:P236	10.11	7	Yes	Yes	6	7	1	1
B:B:F235	B:B:N237	13.29	7	Yes	Yes	6	5	1	1
B:B:F235	B:B:F278	6.43	7	Yes	Yes	6	7	1	2
B:B:?282	B:B:F235	6.37	7	Yes	Yes	9	6	2	1
B:B:F235	G:G:L37	7.31	7	Yes	No	6	7	1	2
B:B:F235	G:G:?40	10.66	7	Yes	Yes	6	6	1	0
B:B:F278	B:B:P236	4.33	7	Yes	Yes	7	7	2	1
B:B:?282	B:B:P236	5.73	7	Yes	Yes	9	7	2	1
B:B:P236	G:G:?40	7.99	7	Yes	Yes	7	6	1	0
B:B:?238	B:B:N237	5.99	7	Yes	Yes	7	5	2	1
B:B:N237	B:B:N239	17.71	7	Yes	Yes	5	2	1	2
B:B:N237	G:G:?40	14.69	7	Yes	Yes	5	6	1	0
B:B:?238	B:B:N239	5.99	7	Yes	Yes	7	2	2	2
B:B:?282	B:B:F278	7.43	7	Yes	Yes	9	7	2	2
B:B:L300	B:B:R283	12.15	7	No	Yes	6	9	2	2
B:B:R283	G:G:?41	5.2	7	Yes	Yes	9	7	2	1
B:B:L300	G:G:?41	5.93	7	No	Yes	6	7	2	1
G:G:?40	G:G:?41	28.83	7	Yes	Yes	6	7	0	1
G:G:?40	G:G:A43	4.6	7	Yes	No	6	4	0	1
G:G:?40	G:G:H44	25.01	7	Yes	No	6	6	0	1
G:G:?41	G:G:E42	4.26	7	Yes	No	7	1	1	2
G:G:A43	G:G:H44	4.39	7	No	No	4	6	1	1
G:G:?40	G:G:A39	3.06	7	Yes	No	6	3	0	1
G:G:?41	G:G:A45	1.69	7	Yes	No	7	4	1	2

Statistics	Value
Average Number Of Links	7.00
Average Number Of Links With An Hub	4.00
Average Interaction Strength	13.55
Average Nodes In Shell	17.00
Average Hubs In Shell	10.00
Average Links In Shell	24.00
Average Links Mediated by Hubs In Shell	23.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TMR in 7FIG
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:?58	R:R:A57	9.19	0	Yes	No	5	4	0	1
R:R:?58	R:R:L59	8.08	0	Yes	No	5	7	0	1
R:R:?58	R:R:Q82	16.83	0	Yes	Yes	5	6	0	1
M:M:H126	R:R:?58	16.26	0	No	Yes	0	5	1	0
R:R:L59	R:R:P60	4.93	0	No	No	7	5	1	2
R:R:Q82	R:R:S81	7.22	0	Yes	No	6	6	1	2
R:R:N107	R:R:Q82	11.88	2	Yes	Yes	7	6	2	1
M:M:?124	R:R:Q82	7.94	0	Yes	Yes	0	6	2	1
L:L:P64	M:M:H126	7.63	0	No	No	0	0	2	1
M:M:H126	M:M:P127	9.15	0	No	No	0	0	1	2

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	12.59
Average Nodes In Shell	11.00
Average Hubs In Shell	4.00
Average Links In Shell	10.00
Average Links Mediated by Hubs In Shell	7.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TMR in 7FIG
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:E87	R:R:R88	13.96	No	No	5	1	2	1
R:R:E87	R:R:R112	19.77	No	No	5	5	2	1
R:R:?113	R:R:R88	14.18	Yes	No	1	1	0	1
R:R:I114	R:R:I89	4.42	Yes	No	8	8	1	2
R:R:I114	R:R:L111	5.71	Yes	No	8	7	1	2
R:R:?113	R:R:R112	4.73	Yes	No	1	5	0	1
R:R:?113	R:R:I114	5.55	Yes	Yes	1	8	0	1
R:R:?113	R:R:E115	16.75	Yes	No	1	5	0	1
R:R:I114	R:R:I135	5.89	Yes	Yes	8	7	1	2
R:R:A91	R:R:E115	3.02	No	No	5	5	2	1

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	10.30
Average Nodes In Shell	10.00
Average Hubs In Shell	3.00
Average Links In Shell	10.00
Average Links Mediated by Hubs In Shell	7.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TMR in 7FIG
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:T110	R:R:E102	8.47	2	No	No	0	7	2	2
L:L:?112	R:R:E102	10.31	2	Yes	No	0	7	1	2
R:R:?126	R:R:?127	12.85	0	Yes	Yes	5	6	1	0
R:R:?126	R:R:E148	6.32	0	Yes	No	5	5	1	2
R:R:?126	R:R:F151	10.17	0	Yes	Yes	5	5	1	2
R:R:?127	R:R:S129	10.22	2	Yes	No	6	7	0	1
R:R:?127	R:R:I152	5.55	2	Yes	Yes	6	4	0	1
R:R:?127	R:R:E154	14.18	2	Yes	Yes	6	7	0	1
L:L:?111	R:R:?127	4.32	2	Yes	Yes	0	6	1	0
L:L:?112	R:R:?127	18.33	2	Yes	Yes	0	6	1	0
R:R:E154	R:R:S129	10.06	2	Yes	No	7	7	1	1
R:R:I152	R:R:T178	4.56	2	Yes	No	4	6	1	2
L:L:?112	R:R:I152	4.16	2	Yes	Yes	0	4	1	1
L:L:?113	R:R:I152	6.94	2	Yes	Yes	0	4	2	1
R:R:?156	R:R:E154	4.26	2	Yes	Yes	7	7	2	1
R:R:?180	R:R:E154	8.7	0	No	Yes	5	7	2	1
L:L:?115	R:R:E154	7.11	2	Yes	Yes	0	7	2	1
L:L:?83	L:L:V85	4.79	2	Yes	Yes	0	0	2	2
L:L:?111	L:L:?83	17.46	2	Yes	Yes	0	0	1	2
L:L:?83	M:M:Q74	11.4	2	Yes	Yes	0	0	2	2
L:L:?112	L:L:V85	4.35	2	Yes	Yes	0	0	1	2
L:L:?111	L:L:T110	9.47	2	Yes	No	0	0	1	2
L:L:?112	L:L:T110	4.3	2	Yes	No	0	0	1	2
L:L:?111	L:L:?112	28.83	2	Yes	Yes	0	0	1	1
L:L:?111	L:L:H114	22.03	2	Yes	Yes	0	0	1	2
L:L:?111	M:M:Q74	5.7	2	Yes	Yes	0	0	1	2
L:L:?112	L:L:?113	39.28	2	Yes	Yes	0	0	1	2
L:L:?112	L:L:H114	7.5	2	Yes	Yes	0	0	1	2
L:L:?112	M:M:Q74	6.47	2	Yes	Yes	0	0	1	2
L:L:?113	L:L:H114	7.5	2	Yes	Yes	0	0	2	2
L:L:?113	M:M:Q74	12.95	2	Yes	Yes	0	0	2	2
L:L:?115	L:L:H114	8.44	2	Yes	Yes	0	0	2	2
R:R:?126	R:R:N150	4.1	0	Yes	No	5	5	1	2

Statistics	Value
Average Number Of Links	6.00
Average Number Of Links With An Hub	5.00
Average Interaction Strength	10.91
Average Nodes In Shell	21.00
Average Hubs In Shell	14.00
Average Links In Shell	33.00
Average Links Mediated by Hubs In Shell	32.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TMR in 7FIG
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:?131	R:R:?156	30.16	2	Yes	Yes	7	7	2	1
R:R:?131	R:R:D157	5.81	2	Yes	No	7	6	2	2
R:R:?131	R:R:N158	5.88	2	Yes	Yes	7	9	2	2
R:R:?156	R:R:E154	4.26	2	Yes	Yes	7	7	1	2
R:R:?180	R:R:E154	8.7	0	No	Yes	5	7	1	2
L:L:?115	R:R:E154	7.11	2	Yes	Yes	0	7	1	2
R:R:I155	R:R:N158	4.25	2	Yes	Yes	8	9	2	2
R:R:I155	R:R:L181	4.28	2	Yes	Yes	8	8	2	2
R:R:I155	R:R:N184	5.66	2	Yes	Yes	8	9	2	1
R:R:?156	R:R:D157	17.44	2	Yes	No	7	6	1	2
R:R:?156	R:R:N158	14.7	2	Yes	Yes	7	9	1	2
R:R:?156	R:R:?182	15.86	2	Yes	Yes	7	6	1	0
R:R:?156	R:R:N184	14.7	2	Yes	Yes	7	9	1	1
M:M:R115	R:R:D157	10.72	2	Yes	No	0	6	1	2
R:R:N158	R:R:N184	6.81	2	Yes	Yes	9	9	2	1
R:R:?180	R:R:L181	6.61	0	No	Yes	5	8	1	2
R:R:?180	R:R:?182	16.87	0	No	Yes	5	6	1	0
R:R:?182	R:R:?183	15.26	2	Yes	Yes	6	7	0	1
R:R:?182	R:R:N184	10.68	2	Yes	Yes	6	9	0	1
R:R:?182	R:R:E203	16.75	2	Yes	No	6	5	0	1
R:R:?182	R:R:?205	8.03	2	Yes	No	6	7	0	1
L:L:?115	R:R:?182	5.62	2	Yes	Yes	0	6	1	0
M:M:R115	R:R:?182	8.27	2	Yes	Yes	0	6	1	0
R:R:?183	R:R:N184	8.38	2	Yes	Yes	7	9	1	1
R:R:?183	R:R:N207	5.99	2	Yes	No	7	9	1	2
M:M:R115	R:R:?183	5.3	2	Yes	Yes	0	7	1	1
R:R:F186	R:R:N184	15.71	2	Yes	Yes	8	9	2	1
R:R:N184	R:R:N207	5.45	2	Yes	No	9	9	1	2
R:R:F186	R:R:N207	10.87	2	Yes	No	8	9	2	2
R:R:E203	R:R:S201	4.31	0	No	No	5	5	1	2
R:R:?205	R:R:E206	9.49	0	No	No	7	4	1	2
R:R:?205	R:R:D228	8.1	0	No	No	7	9	1	2
M:M:R115	R:R:E206	15.12	2	Yes	No	0	4	1	2
L:L:?115	L:L:H114	8.44	2	Yes	Yes	0	0	1	2
L:L:H114	M:M:?113	5.51	2	Yes	No	0	0	2	2
L:L:H114	M:M:?120	15.14	2	Yes	Yes	0	0	2	2
L:L:?115	M:M:?113	6.19	2	Yes	No	0	0	1	2
L:L:?115	M:M:?120	6.19	2	Yes	Yes	0	0	1	2
M:M:?113	M:M:?120	7.94	2	No	Yes	0	0	2	2
L:L:?115	L:L:S116	3.58	2	Yes	No	0	0	1	2

Statistics	Value
Average Number Of Links	8.00
Average Number Of Links With An Hub	5.00
Average Interaction Strength	12.17
Average Nodes In Shell	24.00
Average Hubs In Shell	14.00
Average Links In Shell	40.00
Average Links Mediated by Hubs In Shell	37.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TMR in 7FIG
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:H192	R:R:R219	9.03	0	Yes	No	5	1	2	1
R:R:F194	R:R:F218	13.93	0	Yes	Yes	9	8	2	1
R:R:?216	R:R:R219	4.24	0	No	No	3	1	2	1
R:R:F218	R:R:P224	14.45	0	Yes	Yes	8	8	1	2
R:R:F218	R:R:P238	7.22	0	Yes	No	8	9	1	2
R:R:?240	R:R:F218	4.74	16	Yes	Yes	2	8	0	1
R:R:?240	R:R:R219	23.63	16	Yes	No	2	1	0	1
R:R:?223	R:R:P224	10.02	16	Yes	Yes	7	8	2	2
R:R:?223	R:R:?241	4.21	16	Yes	Yes	7	7	2	1
R:R:?223	R:R:S244	10.48	16	Yes	No	7	4	2	2
R:R:?240	R:R:S239	5.84	16	Yes	No	2	4	0	1
R:R:?240	R:R:?241	23.48	16	Yes	Yes	2	7	0	1
R:R:?240	R:R:E243	14.18	16	Yes	No	2	3	0	1
R:R:?241	R:R:L242	4.83	16	Yes	No	7	9	1	2
R:R:?241	R:R:E243	19.64	16	Yes	No	7	3	1	1
R:R:?241	R:R:S244	6.55	16	Yes	No	7	4	1	2
R:R:N215	R:R:S239	2.98	0	No	No	1	4	2	1
R:R:E243	R:R:V266	1.43	16	No	No	3	4	1	2

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	14.37
Average Nodes In Shell	16.00
Average Hubs In Shell	7.00
Average Links In Shell	18.00
Average Links Mediated by Hubs In Shell	15.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TMR in 7FIG
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:?233	R:R:S255	8.96	0	No	No	3	4	2	1
R:R:?254	R:R:S252	5.84	28	Yes	No	2	7	0	1
R:R:?254	R:R:S255	4.38	28	Yes	No	2	4	0	1
R:R:?254	R:R:?257	5.62	28	Yes	No	2	7	0	1
R:R:?254	R:R:T274	5.73	28	Yes	No	2	9	0	1
R:R:?254	R:R:?275	24.88	28	Yes	Yes	2	8	0	1
R:R:?257	R:R:?258	6.9	28	No	No	7	5	1	2
R:R:?257	R:R:?275	4.82	28	No	Yes	7	8	1	1
R:R:?275	R:R:P276	14.37	28	Yes	No	8	7	1	2
R:R:?275	R:R:I277	4.16	28	Yes	No	8	8	1	2
R:R:?275	R:R:H278	18.76	28	Yes	No	8	9	1	2
R:R:?275	R:R:I431	18.05	28	Yes	No	8	8	1	2
R:R:S231	R:R:S252	3.26	0	No	No	6	7	2	1
R:R:Q235	R:R:S255	1.44	0	No	No	4	4	2	1

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	9.29
Average Nodes In Shell	14.00
Average Hubs In Shell	2.00
Average Links In Shell	14.00
Average Links Mediated by Hubs In Shell	10.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TMR in 7FIG
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:?254	R:R:S252	5.84	28	Yes	No	2	7	1	2
R:R:?254	R:R:S255	4.38	28	Yes	No	2	4	1	2
R:R:?254	R:R:?257	5.62	28	Yes	No	2	7	1	1
R:R:?254	R:R:T274	5.73	28	Yes	No	2	9	1	2
R:R:?254	R:R:?275	24.88	28	Yes	Yes	2	8	1	0
R:R:?257	R:R:?258	6.9	28	No	No	7	5	1	2
R:R:?257	R:R:?275	4.82	28	No	Yes	7	8	1	0
R:R:H278	R:R:L259	9	0	No	No	9	6	1	2
R:R:?275	R:R:P276	14.37	28	Yes	No	8	7	0	1
R:R:?275	R:R:I277	4.16	28	Yes	No	8	8	0	1
R:R:?275	R:R:H278	18.76	28	Yes	No	8	9	0	1
R:R:?275	R:R:I431	18.05	28	Yes	No	8	8	0	1
R:R:P276	R:R:P347	5.84	0	No	No	7	8	1	2
R:R:I431	R:R:T435	7.6	0	No	No	8	6	1	2
R:R:P276	R:R:P345	3.9	0	No	No	7	9	1	2

Statistics	Value
Average Number Of Links	6.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	14.17
Average Nodes In Shell	15.00
Average Hubs In Shell	2.00
Average Links In Shell	15.00
Average Links Mediated by Hubs In Shell	10.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TMR in 7FIG
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:?331	R:R:D330	6.6	17	No	No	1	4	0	1
L:L:F41	R:R:D330	20.3	30	Yes	No	0	4	2	1
R:R:?331	R:R:E332	7.73	17	No	No	1	4	0	1
R:R:?331	R:R:?333	6.55	17	No	Yes	1	1	0	1
R:R:?333	R:R:E332	6.44	17	Yes	No	1	4	1	1
R:R:?333	R:R:?334	18.78	17	Yes	No	1	3	1	2
R:R:?333	R:R:?336	21.62	17	Yes	Yes	1	6	1	2
R:R:?334	R:R:?336	6.46	17	No	Yes	3	6	2	2

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	6.96
Average Nodes In Shell	7.00
Average Hubs In Shell	3.00
Average Links In Shell	8.00
Average Links Mediated by Hubs In Shell	6.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TMR in 7FIG
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:?331	R:R:D330	6.6	17	No	No	1	4	1	2
R:R:?331	R:R:E332	7.73	17	No	No	1	4	1	1
R:R:?331	R:R:?333	6.55	17	No	Yes	1	1	1	0
R:R:?333	R:R:E332	6.44	17	Yes	No	1	4	0	1
R:R:?333	R:R:?334	18.78	17	Yes	No	1	3	0	1
R:R:?333	R:R:?336	21.62	17	Yes	Yes	1	6	0	1
R:R:?334	R:R:?336	6.46	17	No	Yes	3	6	1	1
R:R:?336	R:R:F335	9.13	17	Yes	No	6	1	1	2
R:R:?336	R:R:L337	4.45	17	Yes	No	6	3	1	2
R:R:?336	R:R:P338	5.28	17	Yes	No	6	3	1	2

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	13.35
Average Nodes In Shell	9.00
Average Hubs In Shell	2.00
Average Links In Shell	10.00
Average Links Mediated by Hubs In Shell	8.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TMR in 7FIG
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D355	R:R:R363	9.53	4	Yes	Yes	7	9	2	1
R:R:D355	R:R:D419	6.65	4	Yes	Yes	7	9	2	2
R:R:M357	R:R:R363	4.96	4	No	Yes	7	9	2	1
R:R:D419	R:R:M357	9.7	4	Yes	No	9	7	2	2
R:R:?358	R:R:?359	30.52	0	No	Yes	8	6	1	0
R:R:?359	R:R:D360	5.28	4	Yes	No	6	4	0	1
R:R:?359	R:R:F361	11.85	4	Yes	No	6	5	0	1
R:R:?359	R:R:R363	7.09	4	Yes	Yes	6	9	0	1
R:R:D360	R:R:R363	8.34	4	No	Yes	4	9	1	1
R:R:F361	R:R:L362	9.74	0	No	No	5	8	1	2
R:R:D419	R:R:R363	17.87	4	Yes	Yes	9	9	2	1

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	13.68
Average Nodes In Shell	9.00
Average Hubs In Shell	4.00
Average Links In Shell	11.00
Average Links Mediated by Hubs In Shell	10.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TMR in 7FIG
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
B:B:D312	B:B:D333	6.65	11	No	Yes	5	9	1	2
B:B:D312	R:R:R388	9.53	11	No	No	5	5	1	1
B:B:D312	R:R:?389	11.88	11	No	Yes	5	3	1	0
R:R:?389	R:R:S387	5.84	11	Yes	No	3	7	0	1
R:R:D633	R:R:S387	10.31	11	Yes	No	8	7	1	1
R:R:?389	R:R:R388	18.9	11	Yes	No	3	5	0	1
R:R:?389	R:R:?390	15.26	11	Yes	No	3	4	0	1
R:R:?389	R:R:R632	34.26	11	Yes	No	3	6	0	1
R:R:?389	R:R:D633	9.24	11	Yes	Yes	3	8	0	1
R:R:D633	R:R:R395	8.34	11	Yes	No	8	7	1	2
R:R:D633	R:R:R632	10.72	11	Yes	No	8	6	1	1
R:R:?389	R:R:L636	4.04	11	Yes	No	3	3	0	1
R:R:?390	R:R:L391	2.48	0	No	No	4	5	1	2

Statistics	Value
Average Number Of Links	7.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	14.20
Average Nodes In Shell	11.00
Average Hubs In Shell	3.00
Average Links In Shell	13.00
Average Links Mediated by Hubs In Shell	11.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TMR in 7FIG
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:I366	R:R:N370	4.25	4	Yes	No	9	6	2	2
R:R:I366	R:R:L412	5.71	4	Yes	No	9	8	2	1
R:R:I366	R:R:V609	6.14	4	Yes	No	9	9	2	2
R:R:L412	R:R:N370	5.49	4	No	No	8	6	1	2
R:R:?409	R:R:I374	4.98	4	No	No	9	5	1	2
R:R:?407	R:R:?409	10.34	4	Yes	No	7	9	1	1
R:R:?407	R:R:L410	8.89	4	Yes	No	7	4	1	2
R:R:?407	R:R:?411	5.77	4	Yes	Yes	7	7	1	0
R:R:?409	R:R:?411	9.39	4	No	Yes	9	7	1	0
R:R:?411	R:R:L412	9.42	4	Yes	No	7	8	0	1
R:R:?411	R:R:I415	18.05	4	Yes	No	7	8	0	1
R:R:?411	R:R:T446	10.04	4	Yes	No	7	8	0	1
R:R:?411	R:R:I513	4.16	4	Yes	No	7	9	0	1
R:R:?411	R:R:F515	4.74	4	Yes	Yes	7	9	0	1
R:R:?411	R:R:L608	6.73	4	Yes	No	7	8	0	1
R:R:?443	R:R:T446	9	4	No	No	9	8	2	1
R:R:?443	R:R:?514	7.76	4	No	Yes	9	9	2	2
R:R:F515	R:R:I513	7.54	4	Yes	No	9	9	1	1
R:R:I513	R:R:L608	5.71	4	No	No	9	8	1	1
R:R:?514	R:R:F515	5.22	4	Yes	Yes	9	9	2	1
R:R:F515	R:R:P516	4.33	4	Yes	No	9	9	1	2
R:R:F515	R:R:M517	6.22	4	Yes	No	9	8	1	2
R:R:?612	R:R:F515	11.85	4	Yes	Yes	7	9	2	1
R:R:L608	R:R:V609	4.47	4	No	No	8	9	1	2
R:R:?411	R:R:A442	3.06	4	Yes	No	7	8	0	1
R:R:?411	R:R:L414	2.69	4	Yes	No	7	4	0	1
R:R:?407	R:R:F445	2.61	4	Yes	No	7	7	1	2

Statistics	Value
Average Number Of Links	10.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	7.40
Average Nodes In Shell	22.00
Average Hubs In Shell	6.00
Average Links In Shell	27.00
Average Links Mediated by Hubs In Shell	22.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TMR in 7FIG
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:?427	R:R:A281	6.13	29	Yes	No	7	8	1	2
R:R:N351	R:R:Q434	6.6	0	No	No	8	9	2	1
R:R:E354	R:R:S512	4.31	0	Yes	No	7	9	2	1
R:R:I356	R:R:S512	4.64	0	No	No	8	9	2	1
R:R:H429	R:R:T422	9.58	0	No	No	6	9	1	2
R:R:N428	R:R:Q425	7.92	0	No	No	6	4	2	2
R:R:H429	R:R:Q425	9.89	0	No	No	6	4	1	2
R:R:?426	R:R:?427	28.81	29	Yes	Yes	9	7	0	1
R:R:?426	R:R:H429	6.25	29	Yes	No	9	6	0	1
R:R:?426	R:R:A430	13.79	29	Yes	No	9	9	0	1
R:R:?426	R:R:Q434	7.77	29	Yes	No	9	9	0	1
R:R:?426	R:R:S512	4.38	29	Yes	No	9	9	0	1
R:R:?427	R:R:N428	16.03	29	Yes	No	7	6	1	2
R:R:?427	R:R:A430	6.13	29	Yes	No	7	9	1	1

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	12.20
Average Nodes In Shell	13.00
Average Hubs In Shell	3.00
Average Links In Shell	14.00
Average Links Mediated by Hubs In Shell	9.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TMR in 7FIG
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:A281	R:R:R262	4.15	0	No	No	8	5	1	2
R:R:?427	R:R:A281	6.13	29	Yes	No	7	8	0	1
R:R:N428	R:R:Q425	7.92	0	No	No	6	4	1	2
R:R:H429	R:R:Q425	9.89	0	No	No	6	4	2	2
R:R:?426	R:R:?427	28.81	29	Yes	Yes	9	7	1	0
R:R:?426	R:R:H429	6.25	29	Yes	No	9	6	1	2
R:R:?426	R:R:A430	13.79	29	Yes	No	9	9	1	1
R:R:?426	R:R:Q434	7.77	29	Yes	No	9	9	1	2
R:R:?426	R:R:S512	4.38	29	Yes	No	9	9	1	2
R:R:?427	R:R:N428	16.03	29	Yes	No	7	6	0	1
R:R:?427	R:R:A430	6.13	29	Yes	No	7	9	0	1

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	14.28
Average Nodes In Shell	10.00
Average Hubs In Shell	2.00
Average Links In Shell	11.00
Average Links Mediated by Hubs In Shell	8.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TMR in 7FIG
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:L397	R:R:V459	4.47	0	No	No	7	4	2	1
R:R:L401	R:R:T456	7.37	6	Yes	No	8	8	2	1
R:R:?455	R:R:T456	4.3	0	Yes	No	8	8	0	1
R:R:?455	R:R:T458	12.9	0	Yes	No	8	8	0	1
R:R:?455	R:R:V459	13.04	0	Yes	No	8	4	0	1
R:R:?455	R:R:I486	4.16	0	Yes	No	8	5	0	1
R:R:?455	R:R:?490	10.57	0	Yes	Yes	8	8	0	1
R:R:M487	R:R:T456	6.02	21	Yes	No	7	8	2	1
R:R:I541	R:R:T458	4.56	0	No	No	4	8	2	1
R:R:?489	R:R:?490	13.68	31	No	Yes	3	8	2	1
R:R:?490	R:R:F493	4.25	0	Yes	No	8	5	1	2
R:R:?490	R:R:S494	6.55	0	Yes	No	8	7	1	2
R:R:I486	R:R:L485	1.43	0	No	No	5	2	1	2

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	8.99
Average Nodes In Shell	14.00
Average Hubs In Shell	4.00
Average Links In Shell	13.00
Average Links Mediated by Hubs In Shell	10.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TMR in 7FIG
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:T469	R:R:W465	16.98	No	No	5	5	1	2
R:R:?470	R:R:H466	11.25	Yes	No	3	5	0	1
R:R:?470	R:R:T469	12.9	Yes	No	3	5	0	1
R:R:D475	R:R:Q476	11.75	No	No	4	5	2	1
R:R:?470	R:R:A471	3.06	Yes	No	3	6	0	1
R:R:?470	R:R:Q476	2.59	Yes	No	3	5	0	1

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	7.45
Average Nodes In Shell	7.00
Average Hubs In Shell	1.00
Average Links In Shell	6.00
Average Links Mediated by Hubs In Shell	4.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TMR in 7FIG
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:?510	R:R:F350	6.54	0	No	No	6	8	1	2
R:R:?438	R:R:W433	9.93	4	Yes	Yes	8	9	2	2
R:R:?439	R:R:W433	29.27	4	Yes	Yes	9	9	1	2
R:R:?514	R:R:W433	4.88	4	Yes	Yes	9	9	1	2
R:R:?436	R:R:?438	6.32	4	No	Yes	9	8	2	2
R:R:?436	R:R:?439	6.46	4	No	Yes	9	9	2	1
R:R:?438	R:R:?439	19.39	4	Yes	Yes	8	9	2	1
R:R:?439	R:R:?508	4.32	4	Yes	Yes	9	8	1	0
R:R:?439	R:R:?514	20.63	4	Yes	Yes	9	9	1	1
R:R:L502	R:R:S440	4.5	0	No	No	7	4	2	1
R:R:?508	R:R:S440	7.3	4	Yes	No	8	4	0	1
R:R:?443	R:R:T446	9	4	No	No	9	8	1	2
R:R:?443	R:R:?508	22.31	4	No	Yes	9	8	1	0
R:R:?443	R:R:?514	7.76	4	No	Yes	9	9	1	1
R:R:?508	R:R:V447	5.8	4	Yes	No	8	8	0	1
R:R:?508	R:R:P501	19.17	4	Yes	No	8	9	0	1
R:R:?527	R:R:P501	12.78	0	Yes	No	7	9	2	1
R:R:M509	R:R:N507	8.41	0	No	No	6	7	1	2
R:R:?508	R:R:M509	6.87	4	Yes	No	8	6	0	1
R:R:?508	R:R:?514	18.74	4	Yes	Yes	8	9	0	1
R:R:?508	R:R:P516	7.99	4	Yes	No	8	9	0	1
R:R:?514	R:R:V511	4.79	4	Yes	No	9	9	1	2
R:R:?514	R:R:F515	5.22	4	Yes	Yes	9	9	1	2
R:R:F515	R:R:P516	4.33	4	Yes	No	9	9	2	1
R:R:?508	R:R:?510	4.02	4	Yes	No	8	6	0	1

Statistics	Value
Average Number Of Links	9.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	10.72
Average Nodes In Shell	20.00
Average Hubs In Shell	7.00
Average Links In Shell	25.00
Average Links Mediated by Hubs In Shell	21.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TMR in 7FIG
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F493	R:R:I497	6.28	0	No	No	5	5	2	1
R:R:?527	R:R:I497	5.55	0	Yes	No	7	5	0	1
R:R:?527	R:R:L500	8.08	0	Yes	No	7	5	0	1
R:R:?508	R:R:P501	19.17	4	Yes	No	8	9	2	1
R:R:?527	R:R:P501	12.78	0	Yes	No	7	9	0	1
R:R:?527	R:R:I528	12.49	0	Yes	No	7	6	0	1
R:R:?527	R:R:T530	11.47	0	Yes	No	7	4	0	1
R:R:?527	R:R:I531	6.94	0	Yes	No	7	6	0	1
R:R:L500	R:R:V505	2.98	0	No	No	5	5	1	2
R:R:L534	R:R:T530	2.95	0	No	No	5	4	2	1
R:R:?527	R:R:V526	2.9	0	Yes	No	7	4	0	1
R:R:I497	R:R:L496	2.85	0	No	No	5	3	1	2
R:R:I528	R:R:L532	2.85	0	No	Yes	6	9	1	2
R:R:I531	R:R:L532	2.85	0	No	Yes	6	9	1	2

Statistics	Value
Average Number Of Links	7.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	8.60
Average Nodes In Shell	14.00
Average Hubs In Shell	3.00
Average Links In Shell	14.00
Average Links Mediated by Hubs In Shell	10.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TMR in 7FIG
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
A:A:?391	R:R:R464	16.54	6	Yes	Yes	4	8	2	1
R:R:I460	R:R:R464	5.01	6	No	Yes	9	8	2	1
R:R:?623	R:R:I460	4.16	6	Yes	No	9	9	2	2
R:R:I542	R:R:T461	9.12	0	No	No	8	8	2	1
R:R:?546	R:R:T461	17.2	6	Yes	No	9	8	0	1
R:R:?546	R:R:R464	9.45	6	Yes	Yes	9	8	0	1
R:R:?623	R:R:R464	8.27	6	Yes	Yes	9	8	2	1
R:R:?545	R:R:W465	7.32	6	Yes	No	6	5	1	2
R:R:?543	R:R:I542	4.59	6	Yes	No	7	8	1	2
R:R:?543	R:R:?545	12.7	6	Yes	Yes	7	6	1	1
R:R:?543	R:R:?546	7.21	6	Yes	Yes	7	9	1	0
R:R:?543	R:R:I547	10.7	6	Yes	No	7	5	1	1
R:R:?543	R:R:I575	6.11	6	Yes	No	7	9	1	1
R:R:?545	R:R:?546	25.95	6	Yes	Yes	6	9	1	0
R:R:?545	R:R:?548	5.31	6	Yes	No	6	4	1	2
R:R:?545	R:R:I549	6.11	6	Yes	No	6	9	1	1
R:R:?546	R:R:I547	4.16	6	Yes	No	9	5	0	1
R:R:?546	R:R:I549	11.11	6	Yes	No	9	9	0	1
R:R:?546	R:R:?550	5.24	6	Yes	Yes	9	9	0	1
R:R:?546	R:R:M571	16.5	6	Yes	No	9	8	0	1
R:R:?546	R:R:L574	6.73	6	Yes	No	9	9	0	1
R:R:?546	R:R:I575	4.16	6	Yes	No	9	9	0	1
R:R:?548	R:R:?550	4.82	0	No	Yes	4	9	2	1
R:R:?550	R:R:I549	5.55	6	Yes	No	9	9	1	1
R:R:?550	R:R:F551	8.29	6	Yes	No	9	4	1	2
R:R:?550	R:R:R554	5.91	6	Yes	No	9	5	1	2
R:R:?550	R:R:I567	4.16	6	Yes	No	9	7	1	2
R:R:L574	R:R:L622	4.15	0	No	Yes	9	9	1	2
R:R:?623	R:R:L622	5.38	6	Yes	Yes	9	9	2	2
R:R:?543	R:R:A544	3.37	6	Yes	No	7	3	1	2
R:R:?545	R:R:L462	2.96	6	Yes	No	6	5	1	2

Statistics	Value
Average Number Of Links	10.00
Average Number Of Links With An Hub	4.00
Average Interaction Strength	10.77
Average Nodes In Shell	23.00
Average Hubs In Shell	8.00
Average Links In Shell	31.00
Average Links Mediated by Hubs In Shell	30.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TMR in 7FIG
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
A:A:L394	R:R:I567	5.71	0	No	No	7	7	2	1
R:R:?546	R:R:T461	17.2	6	Yes	No	9	8	1	2
R:R:?546	R:R:R464	9.45	6	Yes	Yes	9	8	1	2
R:R:?543	R:R:?545	12.7	6	Yes	Yes	7	6	2	2
R:R:?543	R:R:?546	7.21	6	Yes	Yes	7	9	2	1
R:R:?543	R:R:I547	10.7	6	Yes	No	7	5	2	2
R:R:?543	R:R:I575	6.11	6	Yes	No	7	9	2	2
R:R:?545	R:R:?546	25.95	6	Yes	Yes	6	9	2	1
R:R:?545	R:R:?548	5.31	6	Yes	No	6	4	2	1
R:R:?545	R:R:I549	6.11	6	Yes	No	6	9	2	1
R:R:?546	R:R:I547	4.16	6	Yes	No	9	5	1	2
R:R:?546	R:R:I549	11.11	6	Yes	No	9	9	1	1
R:R:?546	R:R:?550	5.24	6	Yes	Yes	9	9	1	0
R:R:?546	R:R:M571	16.5	6	Yes	No	9	8	1	2
R:R:?546	R:R:L574	6.73	6	Yes	No	9	9	1	2
R:R:?546	R:R:I575	4.16	6	Yes	No	9	9	1	2
R:R:?548	R:R:?550	4.82	0	No	Yes	4	9	1	0
R:R:?550	R:R:I549	5.55	6	Yes	No	9	9	0	1
R:R:?550	R:R:F551	8.29	6	Yes	No	9	4	0	1
R:R:?550	R:R:R554	5.91	6	Yes	No	9	5	0	1
R:R:?550	R:R:I567	4.16	6	Yes	No	9	7	0	1
R:R:?548	R:R:A552	1.88	0	No	No	4	5	1	2

Statistics	Value
Average Number Of Links	6.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	5.66
Average Nodes In Shell	17.00
Average Hubs In Shell	5.00
Average Links In Shell	22.00
Average Links Mediated by Hubs In Shell	20.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TMR in 7FIG
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:I369	R:R:P613	6.77	0	No	No	8	9	2	1
R:R:A449	R:R:M408	4.83	0	No	No	8	8	2	1
R:R:?612	R:R:M408	8.25	4	Yes	No	7	8	0	1
R:R:M408	R:R:S616	9.2	0	No	No	8	9	1	2
R:R:?411	R:R:I513	4.16	4	Yes	No	7	9	2	2
R:R:?411	R:R:F515	4.74	4	Yes	Yes	7	9	2	1
R:R:E451	R:R:S450	5.75	0	No	No	9	8	2	1
R:R:?612	R:R:S450	4.38	4	Yes	No	7	8	0	1
R:R:F515	R:R:I513	7.54	4	Yes	No	9	9	1	2
R:R:?514	R:R:F515	5.22	4	Yes	Yes	9	9	2	1
R:R:F515	R:R:P516	4.33	4	Yes	No	9	9	1	2
R:R:F515	R:R:M517	6.22	4	Yes	No	9	8	1	2
R:R:?612	R:R:F515	11.85	4	Yes	Yes	7	9	0	1
R:R:?581	R:R:P584	5.28	4	Yes	No	9	9	1	2
R:R:?581	R:R:I585	4.59	4	Yes	No	9	9	1	1
R:R:?581	R:R:?612	4.32	4	Yes	Yes	9	7	1	0
R:R:?581	R:R:I614	6.11	4	Yes	No	9	8	1	2
R:R:?581	R:R:N615	13.23	4	Yes	No	9	9	1	2
R:R:?612	R:R:I585	6.94	4	Yes	No	7	9	0	1
R:R:?612	R:R:P613	15.97	4	Yes	No	7	9	0	1
R:R:?581	R:R:T580	3.16	4	Yes	No	9	6	1	2

Statistics	Value
Average Number Of Links	6.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	8.62
Average Nodes In Shell	20.00
Average Hubs In Shell	5.00
Average Links In Shell	21.00
Average Links Mediated by Hubs In Shell	17.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TMR in 7FIG
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
A:A:?391	R:R:R464	16.54	6	Yes	Yes	4	8	2	1
R:R:I460	R:R:L397	5.71	6	No	No	9	7	1	2
R:R:L401	R:R:M398	4.24	6	Yes	No	8	7	1	1
R:R:?623	R:R:M398	13.75	6	Yes	No	9	7	0	1
R:R:A624	R:R:M398	4.83	0	No	No	7	7	2	1
R:R:D405	R:R:L401	6.79	6	Yes	Yes	9	8	2	1
R:R:L401	R:R:T456	7.37	6	Yes	No	8	8	1	2
R:R:L401	R:R:L457	5.54	6	Yes	No	8	9	1	1
R:R:L401	R:R:N619	8.24	6	Yes	Yes	8	9	1	2
R:R:?623	R:R:L401	5.38	6	Yes	Yes	9	8	0	1
R:R:D405	R:R:N619	8.08	6	Yes	Yes	9	9	2	2
R:R:L457	R:R:N619	9.61	6	No	Yes	9	9	1	2
R:R:?623	R:R:L457	5.38	6	Yes	No	9	9	0	1
R:R:I460	R:R:R464	5.01	6	No	Yes	9	8	1	1
R:R:?623	R:R:I460	4.16	6	Yes	No	9	9	0	1
R:R:?546	R:R:R464	9.45	6	Yes	Yes	9	8	2	1
R:R:?623	R:R:R464	8.27	6	Yes	Yes	9	8	0	1
R:R:?546	R:R:L574	6.73	6	Yes	No	9	9	2	2
R:R:I573	R:R:L622	4.28	0	No	Yes	5	9	2	1
R:R:L574	R:R:L622	4.15	0	No	Yes	9	9	2	1
R:R:L622	R:R:T577	4.42	0	Yes	No	9	9	1	2
R:R:?623	R:R:L622	5.38	6	Yes	Yes	9	9	0	1

Statistics	Value
Average Number Of Links	6.00
Average Number Of Links With An Hub	3.00
Average Interaction Strength	7.05
Average Nodes In Shell	17.00
Average Hubs In Shell	8.00
Average Links In Shell	22.00
Average Links Mediated by Hubs In Shell	20.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TMR in 7FIG
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Shell	Node2Shell
L:L:?61	L:L:R59	14.18	9	Yes	No	0	1
L:L:E80	L:L:R59	10.47	9	No	No	1	1
L:L:R59	M:M:L128	10.93	9	No	No	1	1
L:L:?61	L:L:P62	15.97	9	Yes	No	0	1
L:L:?61	L:L:P64	4.79	9	Yes	No	0	1
L:L:?61	L:L:V77	4.35	9	Yes	Yes	0	1
L:L:?61	L:L:T78	12.9	9	Yes	No	0	1
L:L:?61	L:L:E80	14.18	9	Yes	No	0	1
L:L:?61	M:M:I53	6.94	9	Yes	No	0	1
L:L:?61	M:M:?79	10.47	9	Yes	Yes	0	1
L:L:?61	M:M:L128	9.42	9	Yes	No	0	1
L:L:P62	M:M:L36	4.93	9	No	No	1	2
L:L:P62	M:M:?79	4.79	9	No	Yes	1	1
L:L:S67	L:L:T63	4.8	2	No	Yes	2	2
L:L:T63	L:L:T78	7.85	2	Yes	No	2	1
L:L:P64	L:L:S67	8.91	0	No	No	1	2
L:L:P64	M:M:H126	7.63	0	No	No	1	2
L:L:N76	L:L:V77	4.43	0	No	Yes	2	1
L:L:V77	M:M:?79	4.35	9	Yes	Yes	1	1
L:L:V77	M:M:T118	4.76	9	Yes	No	1	2
L:L:T78	M:M:D119	13.01	0	No	No	1	2
L:L:E80	M:M:?124	11.07	9	No	Yes	1	2
M:M:A34	M:M:I53	6.5	0	No	No	2	1
M:M:L128	M:M:L36	5.54	9	No	No	1	2
M:M:?54	M:M:I53	9.17	0	Yes	No	2	1
M:M:?54	M:M:?79	23.07	0	Yes	Yes	2	1
M:M:?79	M:M:N78	18.7	9	Yes	No	1	2
M:M:?79	M:M:V82	5.8	9	Yes	No	1	2
M:M:?79	M:M:A105	4.6	9	Yes	No	1	2

Statistics	Value
Average Number Of Links	9.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	10.36
Average Nodes In Shell	23.00
Average Hubs In Shell	6.00
Average Links In Shell	29.00
Average Links Mediated by Hubs In Shell	21.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TMR in 7FIG
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:?126	R:R:E148	6.32	0	Yes	No	5	5	2	1
L:L:?89	R:R:E148	9.02	13	Yes	No	0	5	0	1
L:L:R91	R:R:S149	7.91	13	No	No	0	3	2	2
L:L:E101	R:R:S149	8.62	13	No	No	0	3	1	2
L:L:?89	L:L:S88	4.38	13	Yes	Yes	0	0	0	1
L:L:S88	L:L:T104	6.4	13	Yes	No	0	0	1	1
L:L:?89	L:L:E101	12.89	13	Yes	No	0	0	0	1
L:L:?89	L:L:T104	7.17	13	Yes	No	0	0	0	1
L:L:E101	L:L:R91	11.63	13	No	No	0	0	1	2
L:L:?87	L:L:S88	3.58	0	No	Yes	0	0	2	1
L:L:A105	L:L:S88	3.42	0	No	Yes	0	0	2	1

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	8.37
Average Nodes In Shell	10.00
Average Hubs In Shell	3.00
Average Links In Shell	11.00
Average Links Mediated by Hubs In Shell	8.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TMR in 7FIG
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:T110	R:R:E102	8.47	2	No	No	0	7	1	1
L:L:?112	R:R:E102	10.31	2	Yes	No	0	7	0	1
R:R:?126	R:R:?127	12.85	0	Yes	Yes	5	6	2	1
R:R:?127	R:R:S129	10.22	2	Yes	No	6	7	1	2
R:R:?127	R:R:I152	5.55	2	Yes	Yes	6	4	1	1
R:R:?127	R:R:E154	14.18	2	Yes	Yes	6	7	1	2
L:L:?111	R:R:?127	4.32	2	Yes	Yes	0	6	1	1
L:L:?112	R:R:?127	18.33	2	Yes	Yes	0	6	0	1
R:R:E154	R:R:S129	10.06	2	Yes	No	7	7	2	2
R:R:I152	R:R:T178	4.56	2	Yes	No	4	6	1	2
L:L:?112	R:R:I152	4.16	2	Yes	Yes	0	4	0	1
L:L:?113	R:R:I152	6.94	2	Yes	Yes	0	4	1	1
L:L:?115	R:R:E154	7.11	2	Yes	Yes	0	7	2	2
L:L:?83	L:L:?84	23.81	2	Yes	Yes	0	0	2	2
L:L:?83	L:L:V85	4.79	2	Yes	Yes	0	0	2	1
L:L:?111	L:L:?83	17.46	2	Yes	Yes	0	0	1	2
L:L:?83	M:M:Q74	11.4	2	Yes	Yes	0	0	2	1
L:L:?84	L:L:V85	4.79	2	Yes	Yes	0	0	2	1
L:L:S109	L:L:V85	4.85	0	No	Yes	0	0	2	1
L:L:?112	L:L:V85	4.35	2	Yes	Yes	0	0	0	1
L:L:?111	L:L:T110	9.47	2	Yes	No	0	0	1	1
L:L:?112	L:L:T110	4.3	2	Yes	No	0	0	0	1
L:L:?111	L:L:?112	28.83	2	Yes	Yes	0	0	1	0
L:L:?111	L:L:H114	22.03	2	Yes	Yes	0	0	1	1
L:L:?111	M:M:Q74	5.7	2	Yes	Yes	0	0	1	1
L:L:?112	L:L:?113	39.28	2	Yes	Yes	0	0	0	1
L:L:?112	L:L:H114	7.5	2	Yes	Yes	0	0	0	1
L:L:?112	M:M:Q74	6.47	2	Yes	Yes	0	0	0	1
L:L:?113	L:L:H114	7.5	2	Yes	Yes	0	0	1	1
L:L:?113	M:M:A71	9.19	2	Yes	No	0	0	1	2
L:L:?113	M:M:Q74	12.95	2	Yes	Yes	0	0	1	1
L:L:?115	L:L:H114	8.44	2	Yes	Yes	0	0	2	1
L:L:H114	M:M:?113	5.51	2	Yes	No	0	0	1	2
L:L:H114	M:M:?120	15.14	2	Yes	Yes	0	0	1	2
L:L:?115	M:M:?113	6.19	2	Yes	No	0	0	2	2
L:L:?115	M:M:?120	6.19	2	Yes	Yes	0	0	2	2
M:M:?113	M:M:?120	7.94	2	No	Yes	0	0	2	2
R:R:?77	R:R:E102	3.95	0	No	No	5	7	2	1

Statistics	Value
Average Number Of Links	9.00
Average Number Of Links With An Hub	7.00
Average Interaction Strength	13.73
Average Nodes In Shell	22.00
Average Hubs In Shell	14.00
Average Links In Shell	38.00
Average Links Mediated by Hubs In Shell	36.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TMR in 7FIG
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:T110	R:R:E102	8.47	2	No	No	0	7	2	2
L:L:?112	R:R:E102	10.31	2	Yes	No	0	7	1	2
R:R:?127	R:R:I152	5.55	2	Yes	Yes	6	4	2	1
L:L:?111	R:R:?127	4.32	2	Yes	Yes	0	6	2	2
L:L:?112	R:R:?127	18.33	2	Yes	Yes	0	6	1	2
R:R:I152	R:R:T178	4.56	2	Yes	No	4	6	1	2
L:L:?112	R:R:I152	4.16	2	Yes	Yes	0	4	1	1
L:L:?113	R:R:I152	6.94	2	Yes	Yes	0	4	0	1
L:L:?83	L:L:V85	4.79	2	Yes	Yes	0	0	2	2
L:L:?111	L:L:?83	17.46	2	Yes	Yes	0	0	2	2
L:L:?83	M:M:Q74	11.4	2	Yes	Yes	0	0	2	1
L:L:?112	L:L:V85	4.35	2	Yes	Yes	0	0	1	2
L:L:?111	L:L:T110	9.47	2	Yes	No	0	0	2	2
L:L:?112	L:L:T110	4.3	2	Yes	No	0	0	1	2
L:L:?111	L:L:?112	28.83	2	Yes	Yes	0	0	2	1
L:L:?111	L:L:H114	22.03	2	Yes	Yes	0	0	2	1
L:L:?111	M:M:Q74	5.7	2	Yes	Yes	0	0	2	1
L:L:?112	L:L:?113	39.28	2	Yes	Yes	0	0	1	0
L:L:?112	L:L:H114	7.5	2	Yes	Yes	0	0	1	1
L:L:?112	M:M:Q74	6.47	2	Yes	Yes	0	0	1	1
L:L:?113	L:L:H114	7.5	2	Yes	Yes	0	0	0	1
L:L:?113	M:M:A71	9.19	2	Yes	No	0	0	0	1
L:L:?113	M:M:Q74	12.95	2	Yes	Yes	0	0	0	1
L:L:?115	L:L:H114	8.44	2	Yes	Yes	0	0	2	1
L:L:H114	M:M:?113	5.51	2	Yes	No	0	0	1	2
L:L:H114	M:M:?120	15.14	2	Yes	Yes	0	0	1	2
L:L:?115	M:M:?113	6.19	2	Yes	No	0	0	2	2
L:L:?115	M:M:?120	6.19	2	Yes	Yes	0	0	2	2
M:M:?113	M:M:?120	7.94	2	No	Yes	0	0	2	2

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	4.00
Average Interaction Strength	15.17
Average Nodes In Shell	16.00
Average Hubs In Shell	11.00
Average Links In Shell	29.00
Average Links Mediated by Hubs In Shell	28.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TMR in 7FIG
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Shell	Node2Shell
L:L:?31	L:L:D30	10.17	2	Yes	No	1	2
L:L:D30	L:L:P32	4.83	2	No	No	2	2
L:L:?31	L:L:P32	15.83	2	Yes	No	1	2
L:L:?31	L:L:?55	19.05	2	Yes	Yes	1	1
L:L:?31	M:M:R26	20.81	2	Yes	No	1	1
L:L:?31	M:M:?57	7.21	2	Yes	Yes	1	0
L:L:E33	M:M:R26	9.3	0	No	No	2	1
L:L:?54	L:L:?55	16.8	0	No	Yes	2	1
L:L:?54	M:M:T60	5.14	0	No	No	2	2
L:L:?55	L:L:?56	26.98	2	Yes	Yes	1	1
L:L:?55	M:M:?57	11.53	2	Yes	Yes	1	0
L:L:?55	M:M:?58	14.29	2	Yes	Yes	1	1
L:L:?108	L:L:?56	9.52	2	Yes	Yes	2	1
L:L:?56	M:M:?57	27.39	2	Yes	Yes	1	0
L:L:?56	M:M:?58	15.87	2	Yes	Yes	1	1
L:L:F57	M:M:?56	11.68	2	No	No	1	1
L:L:F57	M:M:?57	18.95	2	No	Yes	1	0
M:M:?57	M:M:R26	16.54	2	Yes	No	0	1
M:M:?29	M:M:R30	5.2	0	No	No	1	2
M:M:?29	M:M:?57	12.97	0	No	Yes	1	0
M:M:?29	M:M:?77	14.29	0	No	Yes	1	2
M:M:?56	M:M:?57	21.13	2	No	Yes	1	0
M:M:?57	M:M:?58	21.62	2	Yes	Yes	0	1
M:M:?58	M:M:P59	19.34	2	Yes	No	1	2
M:M:?58	M:M:T60	4.74	2	Yes	No	1	2
M:M:?110	M:M:?58	12.7	2	Yes	Yes	2	1
M:M:?110	M:M:P59	5.28	2	Yes	No	2	2

Statistics	Value
Average Number Of Links	8.00
Average Number Of Links With An Hub	4.00
Average Interaction Strength	17.17
Average Nodes In Shell	19.00
Average Hubs In Shell	8.00
Average Links In Shell	27.00
Average Links Mediated by Hubs In Shell	22.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TMR in 7FIG
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Shell	Node2Shell
L:L:?61	L:L:R59	14.18	9	Yes	No	1	2
L:L:E80	L:L:R59	10.47	9	No	No	2	2
L:L:R59	M:M:L128	10.93	9	No	No	2	2
L:L:?61	L:L:P62	15.97	9	Yes	No	1	1
L:L:?61	L:L:P64	4.79	9	Yes	No	1	2
L:L:?61	L:L:V77	4.35	9	Yes	Yes	1	1
L:L:?61	L:L:T78	12.9	9	Yes	No	1	2
L:L:?61	L:L:E80	14.18	9	Yes	No	1	2
L:L:?61	M:M:I53	6.94	9	Yes	No	1	2
L:L:?61	M:M:?79	10.47	9	Yes	Yes	1	0
L:L:?61	M:M:L128	9.42	9	Yes	No	1	2
L:L:P62	M:M:L36	4.93	9	No	No	1	2
L:L:P62	M:M:?79	4.79	9	No	Yes	1	0
L:L:N76	L:L:V77	4.43	0	No	Yes	2	1
L:L:V77	M:M:?79	4.35	9	Yes	Yes	1	0
L:L:V77	M:M:T118	4.76	9	Yes	No	1	2
M:M:L128	M:M:L36	5.54	9	No	No	2	2
M:M:?54	M:M:I53	9.17	0	Yes	No	1	2
M:M:?54	M:M:?79	23.07	0	Yes	Yes	1	0
M:M:?108	M:M:?54	14.29	2	Yes	Yes	2	1
M:M:?77	M:M:N78	4.41	0	Yes	No	2	1
M:M:?79	M:M:N78	18.7	9	Yes	No	0	1
M:M:?79	M:M:V82	5.8	9	Yes	No	0	1
M:M:?79	M:M:A105	4.6	9	Yes	No	0	1
M:M:A103	M:M:V82	5.09	0	No	No	2	1
L:L:A60	M:M:?54	3.37	0	No	Yes	2	1
M:M:?54	M:M:A55	3.37	0	Yes	No	1	2
M:M:A105	M:M:T52	3.36	0	No	No	1	2

Statistics	Value
Average Number Of Links	7.00
Average Number Of Links With An Hub	3.00
Average Interaction Strength	10.25
Average Nodes In Shell	23.00
Average Hubs In Shell	6.00
Average Links In Shell	28.00
Average Links Mediated by Hubs In Shell	22.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TMR in 7FIG
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Shell	Node2Shell
M:M:T51	M:M:V49	4.76	No	No	2	1
M:M:?102	M:M:V49	13.04	Yes	No	0	1
M:M:E85	M:M:R83	11.63	No	No	1	2
M:M:?102	M:M:F84	14.21	Yes	No	0	1
M:M:A103	M:M:F84	4.16	No	No	2	1
M:M:?102	M:M:E85	7.73	Yes	No	0	1
M:M:?102	M:M:S101	2.92	Yes	No	0	1
M:M:S101	M:M:S86	1.63	No	No	1	2

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	9.48
Average Nodes In Shell	9.00
Average Hubs In Shell	1.00
Average Links In Shell	8.00
Average Links Mediated by Hubs In Shell	4.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

7FIH

Protein

Glycoprotein hormone

Homo sapiens

hCG

Org43553

chim(NtGi1-Gs)/Beta1/Gamma2

3.2

2021-09-29

10.1038/s41586-021-03924-2

A 2D representation of the interactions of TMR in 7FIH
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
A:A:?32	A:A:?34	3.94	0	No	Yes	4	5	2	1
A:A:?34	A:A:?37	7.23	10	Yes	Yes	5	3	1	0
A:A:?34	A:A:R38	9.42	10	Yes	No	5	3	1	1
A:A:?34	B:B:L55	6.61	10	Yes	No	5	6	1	1
A:A:?37	A:A:V36	5.8	10	Yes	No	3	2	0	1
A:A:?37	A:A:R38	4.73	10	Yes	No	3	3	0	1
A:A:?37	A:A:T40	7.17	10	Yes	No	3	6	0	1
A:A:?37	A:A:R42	15.36	10	Yes	No	3	9	0	1
A:A:?37	B:B:L55	13.46	10	Yes	No	3	6	0	1
A:A:N218	A:A:T40	4.39	0	No	No	4	6	2	1
A:A:H220	A:A:T40	13.69	0	No	No	7	6	2	1
A:A:D240	A:A:R42	4.76	0	No	No	7	9	2	1
B:B:D76	B:B:L55	9.5	10	Yes	No	9	6	2	1
A:A:?34	A:A:Q31	3.18	10	Yes	No	5	4	1	2
A:A:R38	R:R:R479	2.13	10	No	No	3	5	1	2

Statistics	Value
Average Number Of Links	6.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	8.96
Average Nodes In Shell	14.00
Average Hubs In Shell	3.00
Average Links In Shell	15.00
Average Links Mediated by Hubs In Shell	11.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TMR in 7FIH
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
A:A:?63	A:A:I62	11.11	No	No	9	9	0	1
A:A:E370	A:A:T369	4.23	No	No	5	9	2	1
A:A:?63	A:A:T369	2.87	No	No	9	9	0	1
A:A:I62	A:A:Q59	2.74	No	No	9	9	1	2
A:A:?63	A:A:H64	2.5	No	No	9	8	0	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	5.49
Average Nodes In Shell	6.00
Average Hubs In Shell	0.00
Average Links In Shell	5.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TMR in 7FIH
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
A:A:?253	A:A:N264	9.35	17	Yes	No	9	9	0	1
A:A:?253	A:A:L297	4.04	17	Yes	No	9	9	0	1
A:A:?253	A:A:I308	18.05	17	Yes	No	9	7	0	1
A:A:?253	A:A:?311	15.71	17	Yes	Yes	9	5	0	1
A:A:?311	A:A:N264	4.01	17	Yes	No	5	9	1	1
A:A:?307	A:A:D310	4.05	17	No	No	5	3	2	2
A:A:?307	A:A:?311	12.05	17	No	Yes	5	5	2	1
A:A:F315	A:A:I308	10.05	0	Yes	No	6	7	2	1
A:A:?311	A:A:D310	15.84	17	Yes	No	5	3	1	2
A:A:?311	A:A:F312	10.66	17	Yes	No	5	8	1	2
A:A:?311	A:A:P313	3.19	17	Yes	No	5	6	1	2
A:A:L297	A:A:V301	2.98	0	No	No	9	7	1	2

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	11.79
Average Nodes In Shell	11.00
Average Hubs In Shell	3.00
Average Links In Shell	12.00
Average Links Mediated by Hubs In Shell	10.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TMR in 7FIH
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
A:A:?253	A:A:N264	9.35	17	Yes	No	9	9	1	1
A:A:?253	A:A:L297	4.04	17	Yes	No	9	9	1	2
A:A:?253	A:A:I308	18.05	17	Yes	No	9	7	1	2
A:A:?253	A:A:?311	15.71	17	Yes	Yes	9	5	1	0
A:A:?311	A:A:N264	4.01	17	Yes	No	5	9	0	1
A:A:?305	A:A:?307	6.9	0	Yes	No	3	5	2	1
A:A:?307	A:A:D310	4.05	17	No	No	5	3	1	1
A:A:?307	A:A:?311	12.05	17	No	Yes	5	5	1	0
A:A:?311	A:A:D310	15.84	17	Yes	No	5	3	0	1
A:A:?311	A:A:F312	10.66	17	Yes	No	5	8	0	1
A:A:F312	A:A:F340	4.29	0	No	Yes	8	6	1	2
A:A:F312	A:A:Q267	3.51	0	No	No	8	4	1	2
A:A:?311	A:A:P313	3.19	17	Yes	No	5	6	0	1

Statistics	Value
Average Number Of Links	6.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	10.24
Average Nodes In Shell	12.00
Average Hubs In Shell	4.00
Average Links In Shell	13.00
Average Links Mediated by Hubs In Shell	11.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TMR in 7FIH
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
A:A:F312	A:A:F340	4.29	0	No	Yes	8	6	2	1
A:A:F315	A:A:F340	12.86	0	Yes	Yes	6	6	2	1
A:A:?318	A:A:T319	7.17	0	Yes	No	7	2	0	1
A:A:?318	A:A:P321	7.99	0	Yes	No	7	4	0	1
A:A:?318	A:A:?339	6.55	0	Yes	Yes	7	3	0	1
A:A:?318	A:A:F340	8.29	0	Yes	Yes	7	6	0	1
A:A:?318	A:A:D343	10.56	0	Yes	No	7	3	0	1
A:A:D323	A:A:P321	4.83	0	No	No	3	4	2	1
A:A:?339	A:A:A324	10.73	0	Yes	No	3	3	1	2
A:A:?338	A:A:?339	16.06	19	No	Yes	5	3	2	1
A:A:?339	A:A:R342	11.82	0	Yes	Yes	3	5	1	2
A:A:D343	A:A:R347	5.96	0	No	No	3	4	1	2
A:A:E314	A:A:F340	3.5	0	No	Yes	5	6	2	1
A:A:?339	A:A:T325	2.87	0	Yes	No	3	1	1	2
A:A:?339	A:A:T335	2.87	0	Yes	No	3	4	1	2

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	8.11
Average Nodes In Shell	16.00
Average Hubs In Shell	5.00
Average Links In Shell	15.00
Average Links Mediated by Hubs In Shell	13.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TMR in 7FIH
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
A:A:?338	A:A:Q294	5.56	19	No	No	5	6	1	2
A:A:F363	A:A:Q294	8.2	19	Yes	No	5	6	2	2
A:A:?318	A:A:T319	7.17	0	Yes	No	7	2	1	2
A:A:?318	A:A:P321	7.99	0	Yes	No	7	4	1	2
A:A:?318	A:A:?339	6.55	0	Yes	Yes	7	3	1	0
A:A:?318	A:A:F340	8.29	0	Yes	Yes	7	6	1	2
A:A:?318	A:A:D343	10.56	0	Yes	No	7	3	1	2
A:A:?339	A:A:A324	10.73	0	Yes	No	3	3	0	1
A:A:P326	A:A:T335	8.74	0	No	No	1	4	2	1
A:A:E330	A:A:T335	4.23	0	No	No	3	4	2	1
A:A:?338	A:A:?339	16.06	19	No	Yes	5	3	1	0
A:A:?338	A:A:F363	5.09	19	No	Yes	5	5	1	2
A:A:?339	A:A:R342	11.82	0	Yes	Yes	3	5	0	1
A:A:L346	A:A:R342	3.64	0	No	Yes	3	5	2	1
A:A:P361	A:A:R342	7.21	0	No	Yes	4	5	2	1
A:A:F363	A:A:R342	6.41	19	Yes	Yes	5	5	2	1
A:A:?339	A:A:T325	2.87	0	Yes	No	3	1	0	1
A:A:?339	A:A:T335	2.87	0	Yes	No	3	4	0	1

Statistics	Value
Average Number Of Links	6.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	8.48
Average Nodes In Shell	17.00
Average Hubs In Shell	5.00
Average Links In Shell	18.00
Average Links Mediated by Hubs In Shell	15.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TMR in 7FIH
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
A:A:F273	A:A:W277	10.02	3	Yes	Yes	9	6	2	1
A:A:F273	A:A:V287	3.93	3	Yes	No	9	5	2	2
A:A:N278	A:A:W277	4.52	0	No	Yes	8	6	2	1
A:A:V287	A:A:W277	4.9	3	No	Yes	5	6	2	1
A:A:H357	A:A:W277	26.45	0	No	Yes	7	6	2	1
A:A:?358	A:A:W277	6.65	3	Yes	Yes	4	6	0	1
A:A:?359	A:A:W277	7.32	3	Yes	Yes	6	6	1	1
A:A:?358	A:A:S286	7.3	3	Yes	No	4	8	0	1
A:A:I382	A:A:S286	9.29	0	No	No	7	8	2	1
A:A:?359	A:A:S349	6.43	3	Yes	No	6	8	1	2
A:A:?358	A:A:?359	21.62	3	Yes	Yes	4	6	0	1
A:A:?358	A:A:?360	10.47	3	Yes	Yes	4	8	0	1
A:A:?358	A:A:R385	8.27	3	Yes	Yes	4	6	0	1
A:A:?358	A:A:R389	7.09	3	Yes	No	4	5	0	1
A:A:?358	A:A:L394	4.04	3	Yes	Yes	4	7	0	1
A:A:?359	A:A:?360	27.39	3	Yes	Yes	6	8	1	1
A:A:?360	A:A:P361	14.37	3	Yes	No	8	4	1	2
A:A:?360	A:A:H362	6.25	3	Yes	Yes	8	9	1	2
A:A:?360	A:A:D378	11.88	3	Yes	No	8	7	1	2
A:A:?360	A:A:D381	13.2	3	Yes	No	8	8	1	2
A:A:?360	A:A:I382	8.33	3	Yes	No	8	7	1	2
A:A:D378	A:A:H362	13.87	3	No	Yes	7	9	2	2
A:A:D381	A:A:R385	16.68	3	No	Yes	8	6	2	1
A:A:D381	R:R:N555	10.77	3	No	Yes	8	7	2	2
A:A:L394	A:A:R385	3.64	3	Yes	Yes	7	6	1	1
A:A:R385	R:R:N555	4.82	3	Yes	Yes	6	7	1	2
A:A:M386	A:A:R389	3.72	0	No	No	3	5	2	1
A:A:L388	A:A:L394	5.54	3	Yes	Yes	8	7	2	1
A:A:L388	R:R:I567	4.28	3	Yes	No	8	7	2	2
A:A:L394	A:A:R389	3.64	3	Yes	No	7	5	1	1
A:A:L394	R:R:?563	4.13	3	Yes	No	7	5	1	2
A:A:L394	R:R:I567	4.28	3	Yes	No	7	7	1	2
A:A:A243	A:A:S286	1.71	0	No	No	8	8	2	1

Statistics	Value
Average Number Of Links	7.00
Average Number Of Links With An Hub	5.00
Average Interaction Strength	9.35
Average Nodes In Shell	24.00
Average Hubs In Shell	10.00
Average Links In Shell	33.00
Average Links Mediated by Hubs In Shell	30.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TMR in 7FIH
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
A:A:?358	A:A:W277	6.65	3	Yes	Yes	4	6	1	2
A:A:?359	A:A:W277	7.32	3	Yes	Yes	6	6	1	2
A:A:?358	A:A:S286	7.3	3	Yes	No	4	8	1	2
A:A:I382	A:A:S286	9.29	0	No	No	7	8	1	2
A:A:F290	A:A:I288	5.02	0	Yes	No	9	9	2	2
A:A:D378	A:A:I288	11.2	3	No	No	7	9	1	2
A:A:F290	A:A:H362	5.66	0	Yes	Yes	9	9	2	1
A:A:P361	A:A:R342	7.21	0	No	Yes	4	5	1	2
A:A:?359	A:A:S349	6.43	3	Yes	No	6	8	1	2
A:A:?358	A:A:?359	21.62	3	Yes	Yes	4	6	1	1
A:A:?358	A:A:?360	10.47	3	Yes	Yes	4	8	1	0
A:A:?358	A:A:R385	8.27	3	Yes	Yes	4	6	1	2
A:A:?358	A:A:R389	7.09	3	Yes	No	4	5	1	2
A:A:?358	A:A:L394	4.04	3	Yes	Yes	4	7	1	2
A:A:?359	A:A:?360	27.39	3	Yes	Yes	6	8	1	0
A:A:?360	A:A:P361	14.37	3	Yes	No	8	4	0	1
A:A:?360	A:A:H362	6.25	3	Yes	Yes	8	9	0	1
A:A:?360	A:A:D378	11.88	3	Yes	No	8	7	0	1
A:A:?360	A:A:D381	13.2	3	Yes	No	8	8	0	1
A:A:?360	A:A:I382	8.33	3	Yes	No	8	7	0	1
A:A:H362	A:A:R374	11.28	3	Yes	No	9	4	1	2
A:A:D378	A:A:H362	13.87	3	No	Yes	7	9	1	1
A:A:?379	A:A:I382	7.64	0	Yes	No	9	7	2	1
A:A:D381	A:A:R385	16.68	3	No	Yes	8	6	1	2
A:A:D381	R:R:N555	10.77	3	No	Yes	8	7	1	2
A:A:L394	A:A:R385	3.64	3	Yes	Yes	7	6	2	2
A:A:R385	R:R:N555	4.82	3	Yes	Yes	6	7	2	2
A:A:L394	A:A:R389	3.64	3	Yes	No	7	5	2	2

Statistics	Value
Average Number Of Links	7.00
Average Number Of Links With An Hub	3.00
Average Interaction Strength	13.13
Average Nodes In Shell	20.00
Average Hubs In Shell	11.00
Average Links In Shell	28.00
Average Links Mediated by Hubs In Shell	26.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TMR in 7FIH
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
A:A:M386	A:A:Q390	4.08	0	No	No	3	5	2	1
A:A:H387	A:A:Q390	6.18	0	No	No	8	5	2	1
A:A:L388	A:A:L393	9.69	3	Yes	No	8	9	2	1
A:A:L388	R:R:I468	4.28	3	Yes	No	8	7	2	1
A:A:?391	A:A:Q390	3.88	3	Yes	No	4	5	0	1
A:A:?391	A:A:E392	6.44	3	Yes	No	4	6	0	1
A:A:?391	A:A:L393	6.73	3	Yes	No	4	9	0	1
A:A:?391	R:R:E463	5.16	3	Yes	No	4	9	0	1
A:A:?391	R:R:R464	8.27	3	Yes	Yes	4	8	0	1
A:A:?391	R:R:T467	11.47	3	Yes	No	4	8	0	1
A:A:?391	R:R:I468	5.55	3	Yes	No	4	7	0	1
A:A:E392	R:R:T627	8.47	3	No	No	6	9	1	2
A:A:E392	R:R:?628	6.32	3	No	No	6	7	1	2
R:R:I460	R:R:L397	7.14	0	No	No	9	7	2	2
R:R:E463	R:R:L397	3.98	3	No	No	9	7	1	2
R:R:I460	R:R:R464	5.01	0	No	Yes	9	8	2	1
R:R:E463	R:R:R464	8.14	3	No	Yes	9	8	1	1
R:R:?623	R:R:R464	7.09	3	Yes	Yes	9	8	2	1
R:R:I468	R:R:I549	5.89	0	No	Yes	7	9	1	2
R:R:?628	R:R:T627	4.4	3	No	No	7	9	2	2

Statistics	Value
Average Number Of Links	7.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	6.79
Average Nodes In Shell	17.00
Average Hubs In Shell	5.00
Average Links In Shell	20.00
Average Links Mediated by Hubs In Shell	13.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TMR in 7FIH
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
A:A:N239	B:B:W332	4.52	0	No	Yes	8	9	2	1
B:B:H54	B:B:I58	7.95	0	Yes	No	9	9	2	1
B:B:?57	B:B:Q75	7.94	0	No	No	9	9	2	1
B:B:?57	B:B:W332	8.83	0	No	Yes	9	9	2	1
B:B:?59	B:B:I58	5.55	2	Yes	No	8	9	0	1
B:B:?59	B:B:Q75	11.65	2	Yes	No	8	9	0	1
B:B:?59	B:B:S316	11.68	2	Yes	Yes	8	9	0	1
B:B:?59	B:B:W332	7.75	2	Yes	Yes	8	9	0	1
B:B:Q75	B:B:W99	5.48	0	No	Yes	9	9	1	2
B:B:N313	B:B:W332	7.91	0	No	Yes	7	9	2	1
B:B:R314	B:B:W332	24.99	2	Yes	Yes	8	9	2	1
B:B:?317	B:B:S316	8.04	2	Yes	Yes	7	9	2	1
B:B:?330	B:B:S316	3.93	2	Yes	Yes	5	9	2	1
B:B:S316	B:B:W332	6.18	2	Yes	Yes	9	9	1	1
B:B:?317	B:B:?330	18.1	2	Yes	Yes	7	5	2	2

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	9.16
Average Nodes In Shell	13.00
Average Hubs In Shell	8.00
Average Links In Shell	15.00
Average Links Mediated by Hubs In Shell	14.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TMR in 7FIH
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
B:B:?85	B:B:R49	10.63	11	Yes	No	4	7	0	1
B:B:I338	B:B:R49	5.01	0	No	No	5	7	2	1
B:B:R49	G:G:F61	4.28	0	No	Yes	7	8	1	2
B:B:S84	B:B:W63	6.18	0	No	Yes	5	7	1	2
B:B:D66	B:B:R68	4.76	0	No	No	8	5	2	1
B:B:D83	B:B:R68	15.48	11	No	No	8	5	1	1
B:B:?85	B:B:R68	13	11	Yes	No	4	5	0	1
B:B:?85	B:B:D83	10.56	11	Yes	No	4	8	0	1
B:B:?85	B:B:S84	8.76	11	Yes	No	4	5	0	1
B:B:?85	B:B:T86	10.04	11	Yes	No	4	6	0	1
B:B:?85	G:G:P60	9.58	11	Yes	No	4	9	0	1
B:B:N88	B:B:T86	11.7	0	No	No	7	6	2	1
G:G:N59	G:G:P60	6.52	11	Yes	No	9	9	2	1
G:G:F61	G:G:N59	4.83	11	Yes	Yes	8	9	2	2
G:G:F61	G:G:P60	4.33	11	Yes	No	8	9	2	1

Statistics	Value
Average Number Of Links	6.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	10.43
Average Nodes In Shell	13.00
Average Hubs In Shell	4.00
Average Links In Shell	15.00
Average Links Mediated by Hubs In Shell	11.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TMR in 7FIH
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
B:B:?103	B:B:H62	5.51	4	Yes	No	8	6	2	1
B:B:?105	B:B:H62	16.26	0	Yes	No	6	6	0	1
B:B:H62	B:B:R150	6.77	4	No	Yes	6	6	1	2
B:B:?64	B:B:W63	4.97	0	No	Yes	5	7	1	2
B:B:?64	B:B:T65	3.86	0	No	No	5	1	1	2
B:B:?105	B:B:?64	9.39	0	Yes	No	6	5	0	1
B:B:L79	B:B:V71	4.47	0	No	Yes	7	8	2	1
B:B:I81	B:B:V71	6.14	0	No	Yes	7	8	2	1
B:B:?103	B:B:V71	4.79	4	Yes	Yes	8	8	2	1
B:B:?105	B:B:V71	13.04	0	Yes	Yes	6	8	0	1
B:B:?103	B:B:R150	3.9	4	Yes	Yes	8	6	2	2
B:B:?105	B:B:?111	3.93	0	Yes	Yes	6	4	0	1
B:B:?105	B:B:F151	14.21	0	Yes	No	6	9	0	1
B:B:?111	B:B:A106	10.73	4	Yes	No	4	6	1	2
B:B:?111	B:B:N110	22.7	4	Yes	Yes	4	4	1	2
B:B:N110	B:B:N125	8.17	4	Yes	No	4	4	2	2
B:B:?111	B:B:V112	7.24	4	Yes	No	4	8	1	2
B:B:?111	B:B:?124	9.17	4	Yes	Yes	4	6	1	2
B:B:?111	B:B:N125	13.36	4	Yes	No	4	4	1	2
B:B:?111	B:B:S136	5.84	4	Yes	No	4	4	1	2
B:B:?124	B:B:V112	8.69	4	Yes	No	6	8	2	2
B:B:?124	B:B:I123	4.16	4	Yes	Yes	6	6	2	2
B:B:F151	B:B:I123	3.77	0	No	Yes	9	6	1	2
B:B:?124	B:B:S136	4.38	4	Yes	No	6	4	2	2
B:B:F151	B:B:I157	11.3	0	No	No	9	7	1	2
B:B:?105	B:B:P107	3.19	0	Yes	No	6	6	0	1

Statistics	Value
Average Number Of Links	6.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	10.00
Average Nodes In Shell	21.00
Average Hubs In Shell	9.00
Average Links In Shell	26.00
Average Links Mediated by Hubs In Shell	24.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TMR in 7FIH
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
B:B:?105	B:B:H62	16.26	0	Yes	No	6	6	1	2
B:B:?105	B:B:?64	9.39	0	Yes	No	6	5	1	2
B:B:?105	B:B:V71	13.04	0	Yes	Yes	6	8	1	2
B:B:?124	B:B:I93	6.94	4	Yes	No	6	7	1	2
B:B:?124	B:B:L95	5.38	4	Yes	No	6	8	1	2
B:B:?105	B:B:?111	3.93	0	Yes	Yes	6	4	1	0
B:B:?105	B:B:F151	14.21	0	Yes	No	6	9	1	2
B:B:?111	B:B:A106	10.73	4	Yes	No	4	6	0	1
B:B:?111	B:B:N110	22.7	4	Yes	Yes	4	4	0	1
B:B:N110	B:B:N125	8.17	4	Yes	No	4	4	1	1
B:B:?127	B:B:N110	10.65	4	No	Yes	4	4	2	1
B:B:?111	B:B:V112	7.24	4	Yes	No	4	8	0	1
B:B:?111	B:B:?124	9.17	4	Yes	Yes	4	6	0	1
B:B:?111	B:B:N125	13.36	4	Yes	No	4	4	0	1
B:B:?111	B:B:S136	5.84	4	Yes	No	4	4	0	1
B:B:?124	B:B:V112	8.69	4	Yes	No	6	8	1	1
B:B:L126	B:B:V112	4.47	0	No	No	5	8	2	1
B:B:?124	B:B:S122	10.22	4	Yes	No	6	8	1	2
B:B:?124	B:B:I123	4.16	4	Yes	Yes	6	6	1	2
B:B:F151	B:B:I123	3.77	0	No	Yes	9	6	2	2
B:B:?124	B:B:V135	10.14	4	Yes	No	6	4	1	2
B:B:?124	B:B:S136	4.38	4	Yes	No	6	4	1	1
B:B:?127	B:B:N125	8.19	4	No	No	4	4	2	1
B:B:?105	B:B:P107	3.19	0	Yes	No	6	6	1	2
B:B:?109	B:B:N110	2.39	0	No	Yes	5	4	2	1

Statistics	Value
Average Number Of Links	7.00
Average Number Of Links With An Hub	3.00
Average Interaction Strength	10.42
Average Nodes In Shell	21.00
Average Hubs In Shell	6.00
Average Links In Shell	25.00
Average Links Mediated by Hubs In Shell	23.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TMR in 7FIH
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
B:B:?77	B:B:L95	9.66	10	No	No	8	8	2	1
B:B:?124	B:B:I93	6.94	4	Yes	No	6	7	0	1
B:B:I93	B:B:V133	6.14	0	No	No	7	4	1	2
B:B:?114	B:B:L95	4.45	4	Yes	No	8	8	2	1
B:B:?124	B:B:L95	5.38	4	Yes	No	6	8	0	1
B:B:?105	B:B:?111	3.93	0	Yes	Yes	6	4	2	1
B:B:?105	B:B:F151	14.21	0	Yes	No	6	9	2	2
B:B:?111	B:B:A106	10.73	4	Yes	No	4	6	1	2
B:B:?111	B:B:N110	22.7	4	Yes	Yes	4	4	1	2
B:B:N110	B:B:N125	8.17	4	Yes	No	4	4	2	2
B:B:?111	B:B:V112	7.24	4	Yes	No	4	8	1	1
B:B:?111	B:B:?124	9.17	4	Yes	Yes	4	6	1	0
B:B:?111	B:B:N125	13.36	4	Yes	No	4	4	1	2
B:B:?111	B:B:S136	5.84	4	Yes	No	4	4	1	1
B:B:?124	B:B:V112	8.69	4	Yes	No	6	8	0	1
B:B:L126	B:B:V112	4.47	0	No	No	5	8	2	1
B:B:?114	B:B:?121	6.35	4	Yes	Yes	8	8	2	2
B:B:?114	B:B:S122	12.86	4	Yes	No	8	8	2	1
B:B:?121	B:B:S122	4.82	4	Yes	No	8	8	2	1
B:B:?121	B:B:L139	4.45	4	Yes	Yes	8	9	2	2
B:B:?124	B:B:S122	10.22	4	Yes	No	6	8	0	1
B:B:?124	B:B:I123	4.16	4	Yes	Yes	6	6	0	1
B:B:I123	B:B:L139	4.28	0	Yes	Yes	6	9	1	2
B:B:F151	B:B:I123	3.77	0	No	Yes	9	6	2	1
B:B:I123	B:B:I171	4.42	0	Yes	No	6	6	1	2
B:B:?124	B:B:V135	10.14	4	Yes	No	6	4	0	1
B:B:?124	B:B:S136	4.38	4	Yes	No	6	4	0	1
B:B:I93	B:B:P94	3.39	0	No	No	7	5	1	2

Statistics	Value
Average Number Of Links	8.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	7.39
Average Nodes In Shell	22.00
Average Hubs In Shell	8.00
Average Links In Shell	28.00
Average Links Mediated by Hubs In Shell	24.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TMR in 7FIH
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
A:A:?206	A:A:?225	9.47	7	Yes	Yes	8	9	2	2
A:A:?206	A:A:Q227	8.13	7	Yes	Yes	8	9	2	1
A:A:?206	B:B:N119	5.99	7	Yes	Yes	8	9	2	1
A:A:?225	A:A:Q227	5.8	7	Yes	Yes	9	9	2	1
A:A:Q227	B:B:N119	9.24	7	Yes	Yes	9	9	1	1
A:A:Q227	B:B:?145	9.06	7	Yes	Yes	9	8	1	0
A:A:R228	B:B:?162	5.3	7	No	Yes	9	9	2	1
A:A:R228	B:B:D186	4.76	7	No	Yes	9	9	2	1
B:B:?115	B:B:?116	10.53	0	Yes	Yes	9	9	2	1
B:B:?116	B:B:L117	4.83	0	Yes	No	9	9	1	2
B:B:?116	B:B:D118	8.28	0	Yes	No	9	9	1	2
B:B:?116	B:B:?145	5.87	0	Yes	Yes	9	8	1	0
B:B:?144	B:B:N119	11.97	7	Yes	Yes	8	9	1	1
B:B:?145	B:B:N119	4.01	7	Yes	Yes	8	9	0	1
B:B:?144	B:B:T143	3.86	7	Yes	No	8	5	1	2
B:B:D163	B:B:T143	4.34	7	Yes	No	9	5	2	2
B:B:?144	B:B:?145	19.96	7	Yes	Yes	8	8	1	0
B:B:?144	B:B:S161	5.24	7	Yes	Yes	8	9	1	2
B:B:?144	B:B:?162	8.42	7	Yes	Yes	8	9	1	1
B:B:?145	B:B:S147	7.3	7	Yes	No	8	9	0	1
B:B:?145	B:B:?162	14.09	7	Yes	Yes	8	9	0	1
B:B:?145	B:B:D186	14.52	7	Yes	Yes	8	9	0	1
B:B:M188	B:B:S147	6.13	0	No	No	8	9	2	1
B:B:?162	B:B:S161	5.24	7	Yes	Yes	9	9	1	2
B:B:D163	B:B:S161	8.83	7	Yes	Yes	9	9	2	2
B:B:?162	B:B:D163	5.92	7	Yes	Yes	9	9	1	2
B:B:?162	B:B:D186	8.28	7	Yes	Yes	9	9	1	1
B:B:?185	B:B:D186	4.73	0	Yes	Yes	5	9	2	1

Statistics	Value
Average Number Of Links	7.00
Average Number Of Links With An Hub	6.00
Average Interaction Strength	10.69
Average Nodes In Shell	19.00
Average Hubs In Shell	13.00
Average Links In Shell	28.00
Average Links Mediated by Hubs In Shell	27.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TMR in 7FIH
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
B:B:L30	B:B:M262	8.48	0	No	No	5	4	2	1
B:B:?250	B:B:T249	4.74	2	Yes	Yes	8	6	1	2
B:B:R251	B:B:T249	6.47	2	Yes	Yes	8	6	2	2
B:B:S265	B:B:T249	4.8	0	No	Yes	2	6	1	2
B:B:?250	B:B:R251	5.2	2	Yes	Yes	8	8	1	2
B:B:?250	B:B:?264	25.95	2	Yes	Yes	8	5	1	0
B:B:?250	B:B:I273	6.11	2	Yes	Yes	8	6	1	2
B:B:?250	B:B:W297	4.88	2	Yes	Yes	8	8	1	1
B:B:E260	B:B:R251	16.28	2	No	Yes	6	8	2	2
B:B:R251	B:B:T263	9.06	2	Yes	No	8	1	2	1
B:B:L252	B:B:L261	4.15	0	No	No	7	5	1	2
B:B:?264	B:B:L252	9.42	2	Yes	No	5	7	0	1
B:B:F278	B:B:L252	3.65	2	Yes	No	7	7	2	1
B:B:E260	B:B:T263	5.64	2	No	No	6	1	2	1
B:B:?264	B:B:M262	12.37	2	Yes	No	5	4	0	1
B:B:?264	B:B:T263	7.17	2	Yes	No	5	1	0	1
B:B:?264	B:B:S265	5.84	2	Yes	No	5	2	0	1
B:B:?264	B:B:W297	14.4	2	Yes	Yes	5	8	0	1
B:B:?264	B:B:A302	7.66	2	Yes	No	5	2	0	1
B:B:?289	B:B:I273	12.49	2	Yes	Yes	7	6	2	2
B:B:?289	B:B:N295	8.01	2	Yes	Yes	7	6	2	2
B:B:?289	B:B:W297	7.75	2	Yes	Yes	7	8	2	1
B:B:N295	B:B:W297	6.78	2	Yes	Yes	6	8	2	1
B:B:N295	B:B:R304	3.62	2	Yes	Yes	6	5	2	2
B:B:R304	B:B:W297	6	2	Yes	Yes	5	8	2	1
B:B:M262	B:B:S31	3.07	0	No	No	4	1	1	2

Statistics	Value
Average Number Of Links	7.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	11.83
Average Nodes In Shell	19.00
Average Hubs In Shell	10.00
Average Links In Shell	26.00
Average Links Mediated by Hubs In Shell	22.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TMR in 7FIH
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
A:A:W281	B:B:D290	4.47	2	Yes	Yes	5	6	2	1
A:A:W281	B:B:R314	7	2	Yes	Yes	5	8	2	2
B:B:?244	B:B:I273	7.47	0	Yes	Yes	5	6	2	1
B:B:?271	B:B:A248	6.75	2	Yes	No	5	5	1	2
B:B:?250	B:B:?264	25.95	2	Yes	Yes	8	5	2	2
B:B:?250	B:B:I273	6.11	2	Yes	Yes	8	6	2	1
B:B:?250	B:B:W297	4.88	2	Yes	Yes	8	8	2	1
B:B:?264	B:B:W297	14.4	2	Yes	Yes	5	8	2	1
B:B:?271	B:B:I269	4.59	2	Yes	No	5	4	1	1
B:B:?289	B:B:I269	6.94	2	Yes	No	7	4	0	1
B:B:?271	B:B:?272	18.1	2	Yes	Yes	5	4	1	1
B:B:?271	B:B:?289	10.09	2	Yes	Yes	5	7	1	0
B:B:?271	B:B:D290	8.72	2	Yes	Yes	5	6	1	1
B:B:?272	B:B:I273	4.98	2	Yes	Yes	4	6	1	1
B:B:?272	B:B:?289	8.22	2	Yes	Yes	4	7	1	0
B:B:?272	B:B:D290	14.2	2	Yes	Yes	4	6	1	1
B:B:?288	B:B:I273	4.98	2	No	Yes	7	6	1	1
B:B:?289	B:B:I273	12.49	2	Yes	Yes	7	6	0	1
B:B:S275	B:B:T274	4.8	0	No	Yes	8	8	2	1
B:B:?288	B:B:T274	5.14	2	No	Yes	7	8	1	1
B:B:?289	B:B:T274	4.3	2	Yes	Yes	7	8	0	1
B:B:R314	B:B:T274	9.06	2	Yes	Yes	8	8	2	1
B:B:?289	B:B:A287	6.13	2	Yes	No	7	6	0	1
B:B:?288	B:B:?289	25.83	2	No	Yes	7	7	1	0
B:B:?289	B:B:D290	5.28	2	Yes	Yes	7	6	0	1
B:B:?289	B:B:N295	8.01	2	Yes	Yes	7	6	0	1
B:B:?289	B:B:W297	7.75	2	Yes	Yes	7	8	0	1
B:B:D290	B:B:R314	7.15	2	Yes	Yes	6	8	1	2
B:B:?294	B:B:N293	7.35	2	No	Yes	5	5	2	2
B:B:N293	B:B:N295	5.45	2	Yes	Yes	5	6	2	1
B:B:N293	B:B:V307	4.43	2	Yes	Yes	5	3	2	2
B:B:?294	B:B:N295	11.76	2	No	Yes	5	6	2	1
B:B:N295	B:B:W297	6.78	2	Yes	Yes	6	8	1	1
B:B:N295	B:B:R304	3.62	2	Yes	Yes	6	5	1	2
B:B:N295	B:B:V307	4.43	2	Yes	Yes	6	3	1	2
B:B:R304	B:B:W297	6	2	Yes	Yes	5	8	2	1
B:B:R304	B:B:V307	3.92	2	Yes	Yes	5	3	2	2
B:B:?272	B:B:D246	3.55	2	Yes	No	4	9	1	2
B:B:?271	B:B:I270	3.06	2	Yes	No	5	3	1	2

Statistics	Value
Average Number Of Links	10.00
Average Number Of Links With An Hub	7.00
Average Interaction Strength	9.50
Average Nodes In Shell	24.00
Average Hubs In Shell	16.00
Average Links In Shell	39.00
Average Links Mediated by Hubs In Shell	39.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TMR in 7FIH
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
B:B:F235	B:B:P236	10.11	2	Yes	Yes	6	7	1	1
B:B:F235	B:B:N237	10.87	2	Yes	Yes	6	5	1	1
B:B:F235	B:B:F278	7.5	2	Yes	Yes	6	7	1	2
B:B:?282	B:B:F235	5.31	2	Yes	Yes	9	6	2	1
B:B:F235	G:G:?40	5.92	2	Yes	Yes	6	6	1	0
B:B:F278	B:B:P236	5.78	2	Yes	Yes	7	7	2	1
B:B:?280	B:B:P236	3.92	0	No	Yes	1	7	2	1
B:B:?282	B:B:P236	4.3	2	Yes	Yes	9	7	2	1
B:B:P236	G:G:?40	6.39	2	Yes	Yes	7	6	1	0
B:B:?238	B:B:N237	8.38	2	Yes	Yes	7	5	2	1
B:B:N237	B:B:N239	6.81	2	Yes	No	5	2	1	2
B:B:N237	G:G:?40	16.03	2	Yes	Yes	5	6	1	0
B:B:?238	B:B:N239	7.18	2	Yes	No	7	2	2	2
B:B:?282	B:B:F278	4.25	2	Yes	Yes	9	7	2	2
B:B:R283	G:G:?41	3.9	0	Yes	Yes	9	7	2	1
G:G:?40	G:G:?41	27.39	2	Yes	Yes	6	7	0	1
G:G:?40	G:G:H44	17.51	2	Yes	No	6	6	0	1
G:G:E47	G:G:H44	3.69	0	No	No	3	6	2	1
G:G:?40	G:G:A39	3.06	2	Yes	No	6	3	0	1
G:G:?41	G:G:E42	2.84	0	Yes	No	7	1	1	2
B:B:A240	B:B:F235	2.77	0	No	Yes	6	6	2	1
G:G:?41	G:G:A45	1.69	0	Yes	No	7	4	1	2
G:G:?40	G:G:A43	1.53	2	Yes	No	6	4	0	1

Statistics	Value
Average Number Of Links	7.00
Average Number Of Links With An Hub	4.00
Average Interaction Strength	11.12
Average Nodes In Shell	18.00
Average Hubs In Shell	9.00
Average Links In Shell	23.00
Average Links Mediated by Hubs In Shell	22.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TMR in 7FIH
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:L56	R:R:L59	5.54	No	Yes	6	7	2	1
R:R:?58	R:R:A57	6.13	Yes	No	5	4	0	1
R:R:?58	R:R:L59	8.08	Yes	Yes	5	7	0	1
R:R:?58	R:R:Q82	15.53	Yes	Yes	5	6	0	1
M:M:?124	R:R:?58	5.62	Yes	Yes	0	5	1	0
R:R:L59	R:R:V61	4.47	Yes	No	7	6	1	2
R:R:Q82	R:R:S81	5.78	Yes	No	6	6	1	2
R:R:N107	R:R:Q82	7.92	Yes	Yes	7	6	2	1
L:L:T70	R:R:Q82	4.25	No	Yes	0	6	2	1
L:L:E80	M:M:?124	5.53	No	Yes	0	0	2	1
M:M:?124	M:M:D125	8.91	Yes	No	0	0	1	2
M:M:?124	M:M:H126	10.74	Yes	No	0	0	1	2
L:L:P64	L:L:S67	3.56	No	No	0	0	2	1
L:L:S67	R:R:?58	2.92	No	Yes	0	5	1	0
R:R:A57	R:R:S55	1.71	No	No	4	4	1	2
R:R:L59	R:R:P60	1.64	Yes	No	7	5	1	2

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	3.00
Average Interaction Strength	7.66
Average Nodes In Shell	17.00
Average Hubs In Shell	5.00
Average Links In Shell	16.00
Average Links Mediated by Hubs In Shell	14.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TMR in 7FIH
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:E87	R:R:R112	9.3	0	No	No	5	5	2	1
R:R:?113	R:R:R88	4.73	1	Yes	No	1	1	0	1
R:R:E115	R:R:R88	11.63	0	No	No	5	1	2	1
R:R:I114	R:R:I89	5.89	1	No	No	8	8	1	2
R:R:L111	R:R:T108	7.37	1	Yes	No	7	8	1	2
R:R:?113	R:R:L111	10.77	1	Yes	Yes	1	7	0	1
R:R:I114	R:R:L111	5.71	1	No	Yes	8	7	1	1
R:R:I135	R:R:L111	7.14	1	Yes	Yes	7	7	1	1
R:R:?113	R:R:R112	13	1	Yes	No	1	5	0	1
R:R:?113	R:R:I114	5.55	1	Yes	No	1	8	0	1
R:R:?113	R:R:I135	5.55	1	Yes	Yes	1	7	0	1
R:R:I135	R:R:T133	7.6	1	Yes	Yes	7	8	1	2
R:R:?134	R:R:I135	3.73	1	Yes	Yes	5	7	2	1
R:R:?137	R:R:I135	4.26	0	No	Yes	3	7	2	1

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	7.92
Average Nodes In Shell	13.00
Average Hubs In Shell	5.00
Average Links In Shell	14.00
Average Links Mediated by Hubs In Shell	11.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TMR in 7FIH
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:?77	R:R:E102	11.86	0	No	Yes	5	7	2	1
R:R:E102	R:R:L104	6.63	1	Yes	No	7	5	1	1
R:R:?127	R:R:E102	7.73	1	Yes	Yes	6	7	0	1
L:L:T110	R:R:E102	7.06	1	Yes	Yes	0	7	2	1
L:L:?112	R:R:E102	9.02	1	Yes	Yes	0	7	2	1
R:R:?127	R:R:L104	6.73	1	Yes	No	6	5	0	1
R:R:?126	R:R:L125	4.13	1	Yes	Yes	5	9	1	2
R:R:F151	R:R:L125	3.65	1	Yes	Yes	5	9	2	2
R:R:?126	R:R:?127	14.46	1	Yes	Yes	5	6	1	0
R:R:?126	R:R:E148	7.11	1	Yes	No	5	5	1	2
R:R:?126	R:R:F151	6.54	1	Yes	Yes	5	5	1	2
L:L:?112	R:R:?126	4.82	1	Yes	Yes	0	5	2	1
R:R:?127	R:R:S129	8.76	1	Yes	No	6	7	0	1
R:R:?127	R:R:E154	9.02	1	Yes	Yes	6	7	0	1
R:R:E154	R:R:S129	14.37	1	Yes	No	7	7	1	1
R:R:?156	R:R:E154	4.26	1	Yes	Yes	7	7	2	1
L:L:?115	R:R:E154	6.32	1	Yes	Yes	0	7	2	1
L:L:?112	L:L:T110	7.17	1	Yes	Yes	0	0	2	2

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	3.00
Average Interaction Strength	9.34
Average Nodes In Shell	14.00
Average Hubs In Shell	10.00
Average Links In Shell	18.00
Average Links Mediated by Hubs In Shell	18.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TMR in 7FIH
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:?131	R:R:?156	31.75	1	Yes	Yes	7	7	2	1
R:R:?131	R:R:D157	4.36	1	Yes	Yes	7	6	2	2
R:R:?156	R:R:E154	4.26	1	Yes	Yes	7	7	1	2
R:R:I155	R:R:L181	4.28	0	No	Yes	8	8	2	2
R:R:I155	R:R:N184	7.08	0	No	Yes	8	9	2	1
R:R:?156	R:R:D157	14.53	1	Yes	Yes	7	6	1	2
R:R:?156	R:R:N158	13.23	1	Yes	Yes	7	9	1	2
R:R:?156	R:R:?182	4.32	1	Yes	Yes	7	6	1	0
R:R:?156	R:R:N184	13.23	1	Yes	Yes	7	9	1	1
M:M:R115	R:R:D157	8.34	1	No	Yes	0	6	1	2
R:R:N158	R:R:N184	5.45	1	Yes	Yes	9	9	2	1
R:R:?180	R:R:L181	4.95	1	Yes	Yes	5	8	1	2
R:R:?180	R:R:?182	4.02	1	Yes	Yes	5	6	1	0
R:R:?180	R:R:E203	5.53	1	Yes	No	5	5	1	1
L:L:?113	R:R:?180	4.02	1	Yes	Yes	0	5	2	1
R:R:F186	R:R:L181	4.87	0	Yes	Yes	8	8	2	2
R:R:?182	R:R:?183	15.26	1	Yes	Yes	6	7	0	1
R:R:?182	R:R:N184	9.35	1	Yes	Yes	6	9	0	1
R:R:?182	R:R:E203	19.33	1	Yes	No	6	5	0	1
R:R:?182	R:R:?205	13.65	1	Yes	No	6	7	0	1
M:M:R115	R:R:?182	11.82	1	No	Yes	0	6	1	0
R:R:?183	R:R:N184	4.79	1	Yes	Yes	7	9	1	1
R:R:?183	R:R:N207	5.99	1	Yes	No	7	9	1	2
M:M:R115	R:R:?183	5.3	1	No	Yes	0	7	1	1
R:R:F186	R:R:N184	14.5	0	Yes	Yes	8	9	2	1
R:R:F186	R:R:N207	7.25	0	Yes	No	8	9	2	2
R:R:E203	R:R:S201	4.31	1	No	No	5	5	1	2
R:R:?205	R:R:E206	4.74	0	No	No	7	4	1	2
R:R:?205	R:R:D228	5.67	0	No	No	7	9	1	2

Statistics	Value
Average Number Of Links	7.00
Average Number Of Links With An Hub	4.00
Average Interaction Strength	11.11
Average Nodes In Shell	20.00
Average Hubs In Shell	12.00
Average Links In Shell	29.00
Average Links Mediated by Hubs In Shell	26.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TMR in 7FIH
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:H192	R:R:R219	6.77	0	No	No	5	1	2	1
R:R:N215	R:R:S239	4.47	0	No	No	1	4	2	1
R:R:?216	R:R:R219	8.48	27	Yes	No	3	1	2	1
R:R:F218	R:R:P224	11.56	0	No	No	8	8	1	2
R:R:F218	R:R:P238	7.22	0	No	No	8	9	1	2
R:R:?240	R:R:F218	4.74	0	Yes	No	2	8	0	1
R:R:?240	R:R:R219	20.09	0	Yes	No	2	1	0	1
R:R:?223	R:R:P224	10.02	0	Yes	No	7	8	2	2
R:R:?223	R:R:?241	4.21	0	Yes	Yes	7	7	2	1
R:R:?240	R:R:?241	23.48	0	Yes	Yes	2	7	0	1
R:R:?241	R:R:L242	4.83	0	Yes	No	7	9	1	2
R:R:?241	R:R:E243	5.78	0	Yes	No	7	3	1	2
R:R:?240	R:R:S239	2.92	0	Yes	No	2	4	0	1

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	12.81
Average Nodes In Shell	13.00
Average Hubs In Shell	4.00
Average Links In Shell	13.00
Average Links Mediated by Hubs In Shell	9.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TMR in 7FIH
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:?233	R:R:S255	8.06	0	No	No	3	4	2	1
R:R:?254	R:R:S255	4.38	14	No	No	2	4	0	1
R:R:?254	R:R:T274	5.73	14	No	No	2	9	0	1
R:R:?254	R:R:?275	20.95	14	No	Yes	2	8	0	1
R:R:?275	R:R:T274	11.47	14	Yes	No	8	9	1	1
R:R:?275	R:R:P276	14.37	14	Yes	No	8	7	1	2
R:R:?275	R:R:H278	18.76	14	Yes	Yes	8	9	1	2
R:R:?275	R:R:I431	20.82	14	Yes	No	8	8	1	2
R:R:H278	R:R:I431	3.98	14	Yes	No	9	8	2	2

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	10.35
Average Nodes In Shell	8.00
Average Hubs In Shell	2.00
Average Links In Shell	9.00
Average Links Mediated by Hubs In Shell	6.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TMR in 7FIH
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:?254	R:R:S255	4.38	14	No	No	2	4	1	2
R:R:?254	R:R:T274	5.73	14	No	No	2	9	1	1
R:R:?254	R:R:?275	20.95	14	No	Yes	2	8	1	0
R:R:?257	R:R:H278	5.37	14	No	Yes	7	9	2	1
R:R:?257	R:R:I431	6.81	14	No	No	7	8	2	1
R:R:H278	R:R:L259	9	14	Yes	Yes	9	6	1	2
R:R:?275	R:R:T274	11.47	14	Yes	No	8	9	0	1
R:R:?275	R:R:P276	14.37	14	Yes	No	8	7	0	1
R:R:?275	R:R:H278	18.76	14	Yes	Yes	8	9	0	1
R:R:?275	R:R:I431	20.82	14	Yes	No	8	8	0	1
R:R:H278	R:R:I431	3.98	14	Yes	No	9	8	1	1
R:R:P276	R:R:P345	1.95	0	No	No	7	9	1	2

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	17.27
Average Nodes In Shell	10.00
Average Hubs In Shell	3.00
Average Links In Shell	12.00
Average Links Mediated by Hubs In Shell	8.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TMR in 7FIH
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:?331	R:R:D330	11.88	30	Yes	No	1	4	0	1
R:R:D330	R:R:E332	3.9	30	No	No	4	4	1	1
R:R:?331	R:R:E332	6.44	30	Yes	No	1	4	0	1
R:R:?331	R:R:?333	6.55	30	Yes	No	1	1	0	1
R:R:?333	R:R:?334	11.74	0	No	No	1	3	1	2
L:L:F41	L:L:N39	4.83	0	No	Yes	0	0	1	2
M:M:L69	M:M:R63	9.72	0	No	No	0	0	2	1
M:M:L72	M:M:R63	17.01	0	No	No	0	0	2	1
M:M:R63	R:R:?331	3.54	0	No	Yes	0	1	1	0
L:L:F41	L:L:F42	3.22	0	No	No	0	0	1	2
L:L:F41	R:R:?331	2.37	0	No	Yes	0	1	1	0

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	6.16
Average Nodes In Shell	11.00
Average Hubs In Shell	2.00
Average Links In Shell	11.00
Average Links Mediated by Hubs In Shell	6.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TMR in 7FIH
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:?331	R:R:D330	11.88	30	Yes	No	1	4	1	2
R:R:D330	R:R:E332	3.9	30	No	No	4	4	2	2
R:R:?331	R:R:E332	6.44	30	Yes	No	1	4	1	2
R:R:?331	R:R:?333	6.55	30	Yes	No	1	1	1	0
R:R:?333	R:R:?334	11.74	0	No	No	1	3	0	1
R:R:?334	R:R:F335	11.68	0	No	No	3	1	1	2
M:M:R63	R:R:?331	3.54	0	No	Yes	0	1	2	1
L:L:F41	R:R:?331	2.37	0	No	Yes	0	1	2	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	9.14
Average Nodes In Shell	8.00
Average Hubs In Shell	1.00
Average Links In Shell	8.00
Average Links Mediated by Hubs In Shell	5.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TMR in 7FIH
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:?358	R:R:?359	23.48	0	No	Yes	8	6	1	0
R:R:?359	R:R:D360	7.92	31	Yes	No	6	4	0	1
R:R:?359	R:R:F361	8.29	31	Yes	No	6	5	0	1
R:R:?359	R:R:L362	9.42	31	Yes	Yes	6	8	0	1
R:R:?359	R:R:N603	10.68	31	Yes	No	6	6	0	1
R:R:F361	R:R:L362	8.53	31	No	Yes	5	8	1	1
R:R:F361	R:R:L365	3.65	31	No	No	5	6	1	2
R:R:L362	R:R:V606	4.47	31	Yes	No	8	7	1	2
R:R:L362	R:R:V609	8.94	31	Yes	No	8	9	1	2
R:R:I599	R:R:N603	5.66	0	No	No	8	6	2	1
R:R:N603	R:R:T600	4.39	0	No	No	6	8	1	2
R:R:?358	R:R:E354	3.47	0	No	Yes	8	7	1	2

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	11.96
Average Nodes In Shell	12.00
Average Hubs In Shell	3.00
Average Links In Shell	12.00
Average Links Mediated by Hubs In Shell	9.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TMR in 7FIH
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
B:B:D312	R:R:?389	10.56	0	No	Yes	5	3	1	0
R:R:?389	R:R:S387	13.14	25	Yes	No	3	7	0	1
R:R:R395	R:R:S387	6.59	0	No	No	7	7	2	1
R:R:D633	R:R:S387	7.36	0	No	No	8	7	2	1
R:R:?389	R:R:R388	5.91	25	Yes	No	3	5	0	1
R:R:L636	R:R:R388	3.64	25	No	No	3	5	1	1
R:R:?389	R:R:?390	13.65	25	Yes	No	3	4	0	1
R:R:?389	R:R:R632	9.45	25	Yes	No	3	6	0	1
R:R:?389	R:R:L636	4.04	25	Yes	No	3	3	0	1
R:R:?390	R:R:L391	5.78	0	No	No	4	5	1	2
R:R:L636	R:R:L637	1.38	25	No	No	3	7	1	2

Statistics	Value
Average Number Of Links	6.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	9.46
Average Nodes In Shell	11.00
Average Hubs In Shell	1.00
Average Links In Shell	11.00
Average Links Mediated by Hubs In Shell	6.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TMR in 7FIH
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:I366	R:R:L412	4.28	0	No	No	9	8	2	1
R:R:F406	R:R:I374	3.77	6	No	No	4	5	2	2
R:R:?409	R:R:I374	4.98	6	Yes	No	9	5	1	2
R:R:?407	R:R:F403	5.22	6	Yes	No	7	5	1	2
R:R:?407	R:R:F406	3.91	6	Yes	No	7	4	1	2
R:R:F406	R:R:L410	14.61	6	No	No	4	4	2	2
R:R:?407	R:R:?409	10.34	6	Yes	Yes	7	9	1	1
R:R:?407	R:R:L410	8.89	6	Yes	No	7	4	1	2
R:R:?407	R:R:?411	5.77	6	Yes	Yes	7	7	1	0
R:R:?407	R:R:A449	5.06	6	Yes	No	7	8	1	2
R:R:?409	R:R:M408	3.7	6	Yes	No	9	8	1	2
R:R:?612	R:R:M408	9.62	6	Yes	No	7	8	2	2
R:R:?409	R:R:L410	3.62	6	Yes	No	9	4	1	2
R:R:?409	R:R:?411	9.39	6	Yes	Yes	9	7	1	0
R:R:?409	R:R:L412	3.62	6	Yes	No	9	8	1	1
R:R:?411	R:R:L412	9.42	6	Yes	No	7	8	0	1
R:R:?411	R:R:L414	4.04	6	Yes	No	7	4	0	1
R:R:?411	R:R:I415	18.05	6	Yes	No	7	8	0	1
R:R:?411	R:R:F445	4.74	6	Yes	No	7	7	0	1
R:R:?411	R:R:T446	11.47	6	Yes	No	7	8	0	1
R:R:?411	R:R:F515	5.92	6	Yes	Yes	7	9	0	1
R:R:F445	R:R:T441	5.19	0	No	No	7	3	1	2
R:R:?443	R:R:T446	10.28	6	Yes	No	9	8	2	1
R:R:?443	R:R:?514	5.17	6	Yes	Yes	9	9	2	2
R:R:F515	R:R:T446	5.19	6	Yes	No	9	8	1	1
R:R:F515	R:R:I513	8.79	6	Yes	No	9	9	1	2
R:R:I513	R:R:L608	8.56	6	No	No	9	8	2	2
R:R:?514	R:R:F515	3.91	6	Yes	Yes	9	9	2	1
R:R:F515	R:R:P516	4.33	6	Yes	No	9	9	1	2
R:R:F515	R:R:L608	3.65	6	Yes	No	9	8	1	2
R:R:?612	R:R:F515	10.66	6	Yes	Yes	7	9	2	1
R:R:F515	W:W:?801	12.52	6	Yes	Yes	9	0	1	2
R:R:P516	W:W:?801	6.03	6	No	Yes	9	0	2	2
R:R:?612	W:W:?801	3.95	6	Yes	Yes	7	0	2	2
R:R:?409	R:R:A373	1.37	6	Yes	No	9	9	1	2

Statistics	Value
Average Number Of Links	8.00
Average Number Of Links With An Hub	3.00
Average Interaction Strength	8.60
Average Nodes In Shell	25.00
Average Hubs In Shell	8.00
Average Links In Shell	35.00
Average Links Mediated by Hubs In Shell	30.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TMR in 7FIH
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:?427	R:R:I277	6.94	8	Yes	No	7	8	1	2
R:R:A430	R:R:I277	4.87	8	No	No	9	8	1	2
R:R:?280	R:R:?427	4.32	8	Yes	Yes	9	7	2	1
R:R:?427	R:R:A281	9.19	8	Yes	No	7	8	1	2
R:R:N351	R:R:Q434	3.96	0	No	No	8	9	2	1
R:R:I356	R:R:W433	4.7	0	No	No	8	9	2	1
R:R:V418	R:R:W433	17.16	0	No	No	7	9	2	1
R:R:?426	R:R:T422	7.17	8	Yes	No	9	9	0	1
R:R:H429	R:R:T422	4.11	0	No	No	6	9	2	1
R:R:?426	R:R:?427	27.5	8	Yes	Yes	9	7	0	1
R:R:?426	R:R:A430	12.26	8	Yes	No	9	9	0	1
R:R:?426	R:R:W433	7.75	8	Yes	No	9	9	0	1
R:R:?426	R:R:Q434	5.18	8	Yes	No	9	9	0	1
R:R:?426	R:R:S512	4.38	8	Yes	No	9	9	0	1
R:R:?427	R:R:N428	18.7	8	Yes	No	7	6	1	2
R:R:?427	R:R:A430	4.6	8	Yes	No	7	9	1	1
R:R:Q421	R:R:T422	1.42	0	No	No	3	9	2	1

Statistics	Value
Average Number Of Links	6.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	10.71
Average Nodes In Shell	16.00
Average Hubs In Shell	3.00
Average Links In Shell	17.00
Average Links Mediated by Hubs In Shell	11.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TMR in 7FIH
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:?427	R:R:I277	6.94	8	Yes	No	7	8	0	1
R:R:A430	R:R:I277	4.87	8	No	No	9	8	1	1
R:R:?279	R:R:?280	26.98	8	No	Yes	9	9	2	1
R:R:?280	R:R:R283	5.2	8	Yes	Yes	9	3	1	2
R:R:?280	R:R:?353	15.87	8	Yes	No	9	9	1	2
R:R:?280	R:R:?427	4.32	8	Yes	Yes	9	7	1	0
R:R:?427	R:R:A281	9.19	8	Yes	No	7	8	0	1
R:R:?353	R:R:R283	5.2	8	No	Yes	9	3	2	2
R:R:?426	R:R:T422	7.17	8	Yes	No	9	9	1	2
R:R:N428	R:R:Q425	5.28	0	No	No	6	4	1	2
R:R:?426	R:R:?427	27.5	8	Yes	Yes	9	7	1	0
R:R:?426	R:R:A430	12.26	8	Yes	No	9	9	1	1
R:R:?426	R:R:W433	7.75	8	Yes	No	9	9	1	2
R:R:?426	R:R:Q434	5.18	8	Yes	No	9	9	1	2
R:R:?426	R:R:S512	4.38	8	Yes	No	9	9	1	2
R:R:?427	R:R:N428	18.7	8	Yes	No	7	6	0	1
R:R:?427	R:R:A430	4.6	8	Yes	No	7	9	0	1

Statistics	Value
Average Number Of Links	6.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	11.88
Average Nodes In Shell	15.00
Average Hubs In Shell	4.00
Average Links In Shell	17.00
Average Links Mediated by Hubs In Shell	15.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TMR in 7FIH
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:L401	R:R:T456	7.37	32	No	No	8	8	2	1
R:R:?455	R:R:V454	4.35	0	Yes	No	8	7	0	1
R:R:N535	R:R:V454	4.43	0	No	No	9	7	2	1
R:R:?455	R:R:T456	4.3	0	Yes	No	8	8	0	1
R:R:?455	R:R:T458	15.77	0	Yes	No	8	8	0	1
R:R:?455	R:R:V459	11.59	0	Yes	No	8	4	0	1
R:R:?455	R:R:?490	8.22	0	Yes	Yes	8	8	0	1
R:R:I541	R:R:T458	4.56	0	No	No	4	8	2	1
R:R:M487	R:R:V459	4.56	15	No	No	7	4	2	1
R:R:?489	R:R:?490	13.68	0	No	Yes	3	8	2	1
R:R:?490	R:R:W491	3.97	0	Yes	Yes	8	5	1	2
R:R:?490	R:R:S494	3.93	0	Yes	No	8	7	1	2
R:R:I486	R:R:V459	3.07	0	No	No	5	4	2	1
R:R:A538	R:R:V454	1.7	0	No	No	9	7	2	1

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	8.85
Average Nodes In Shell	15.00
Average Hubs In Shell	3.00
Average Links In Shell	14.00
Average Links Mediated by Hubs In Shell	8.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TMR in 7FIH
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:T469	R:R:W465	9.7	No	Yes	5	5	1	2
R:R:?470	R:R:H466	10	No	No	3	5	0	1
R:R:?470	R:R:T469	12.9	No	No	3	5	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	11.45
Average Nodes In Shell	4.00
Average Hubs In Shell	1.00
Average Links In Shell	3.00
Average Links Mediated by Hubs In Shell	1.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TMR in 7FIH
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:M509	R:R:T435	7.53	0	No	No	6	6	1	2
R:R:?436	R:R:?438	6.32	6	No	Yes	9	8	2	2
R:R:?436	R:R:?439	6.46	6	No	Yes	9	9	2	1
R:R:?438	R:R:?439	19.39	6	Yes	Yes	8	9	2	1
R:R:?439	R:R:S440	4.82	6	Yes	No	9	4	1	2
R:R:?439	R:R:A442	5.06	6	Yes	No	9	8	1	2
R:R:?439	R:R:?443	3.88	6	Yes	Yes	9	9	1	1
R:R:?439	R:R:?508	4.32	6	Yes	Yes	9	8	1	0
R:R:?439	R:R:?514	19.05	6	Yes	Yes	9	9	1	1
R:R:?443	R:R:T446	10.28	6	Yes	No	9	8	1	2
R:R:?443	R:R:V447	3.9	6	Yes	No	9	8	1	1
R:R:?443	R:R:?508	22.31	6	Yes	Yes	9	8	1	0
R:R:?443	R:R:?514	5.17	6	Yes	Yes	9	9	1	1
R:R:F515	R:R:T446	5.19	6	Yes	No	9	8	2	2
R:R:?508	R:R:V447	7.24	6	Yes	No	8	8	0	1
R:R:?508	R:R:P501	20.76	6	Yes	No	8	9	0	1
R:R:?527	R:R:P501	6.39	18	Yes	No	7	9	2	1
R:R:?508	R:R:L502	4.04	6	Yes	No	8	7	0	1
R:R:?508	R:R:M509	4.12	6	Yes	No	8	6	0	1
R:R:?508	R:R:?514	23.07	6	Yes	Yes	8	9	0	1
R:R:?508	R:R:P516	7.99	6	Yes	No	8	9	0	1
R:R:?514	R:R:V511	4.79	6	Yes	No	9	9	1	2
R:R:?514	R:R:F515	3.91	6	Yes	Yes	9	9	1	2
R:R:F515	R:R:P516	4.33	6	Yes	No	9	9	2	1
R:R:F515	W:W:?801	12.52	6	Yes	Yes	9	0	2	2
R:R:P516	W:W:?801	6.03	6	No	Yes	9	0	1	2
R:R:A498	R:R:V447	3.39	0	No	No	9	8	2	1

Statistics	Value
Average Number Of Links	8.00
Average Number Of Links With An Hub	3.00
Average Interaction Strength	11.73
Average Nodes In Shell	20.00
Average Hubs In Shell	8.00
Average Links In Shell	27.00
Average Links Mediated by Hubs In Shell	25.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TMR in 7FIH
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:E451	R:R:I531	5.47	0	No	No	9	6	2	1
R:R:F493	R:R:I497	6.28	0	No	Yes	5	5	2	1
R:R:?527	R:R:I497	5.55	18	Yes	Yes	7	5	0	1
R:R:I497	R:R:I531	5.89	18	Yes	No	5	6	1	1
R:R:L500	R:R:V505	8.94	18	No	Yes	5	5	1	1
R:R:?527	R:R:L500	4.04	18	Yes	No	7	5	0	1
R:R:?508	R:R:P501	20.76	6	Yes	No	8	9	2	1
R:R:?527	R:R:P501	6.39	18	Yes	No	7	9	0	1
R:R:?504	R:R:V505	3.9	0	No	Yes	6	5	2	1
R:R:L523	R:R:V505	5.96	0	No	Yes	4	5	2	1
R:R:?527	R:R:V505	4.35	18	Yes	Yes	7	5	0	1
R:R:S506	R:R:S524	4.89	0	No	No	8	7	1	2
R:R:?527	R:R:S506	4.38	18	Yes	No	7	8	0	1
R:R:?527	R:R:V526	5.8	18	Yes	No	7	4	0	1
R:R:?527	R:R:I528	11.11	18	Yes	No	7	6	0	1
R:R:?527	R:R:T530	7.17	18	Yes	No	7	4	0	1
R:R:?527	R:R:I531	15.27	18	Yes	No	7	6	0	1
R:R:I528	W:W:?801	5.24	0	No	Yes	6	0	1	2
R:R:I497	R:R:L496	2.85	18	Yes	No	5	3	1	2

Statistics	Value
Average Number Of Links	9.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	7.12
Average Nodes In Shell	18.00
Average Hubs In Shell	5.00
Average Links In Shell	19.00
Average Links Mediated by Hubs In Shell	17.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TMR in 7FIH
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:?623	R:R:M398	8.25	3	Yes	No	9	7	1	2
R:R:I542	R:R:T461	13.68	0	No	No	8	8	2	1
R:R:?546	R:R:T461	14.34	3	Yes	No	9	8	0	1
R:R:?623	R:R:R464	7.09	3	Yes	Yes	9	8	1	2
R:R:?545	R:R:W465	8.54	3	Yes	Yes	6	5	1	2
R:R:?548	R:R:W465	4.08	3	Yes	Yes	4	5	1	2
R:R:I549	R:R:W465	4.7	3	Yes	Yes	9	5	1	2
R:R:I468	R:R:I549	5.89	0	No	Yes	7	9	2	1
R:R:?543	R:R:I542	4.59	3	Yes	No	7	8	1	2
R:R:?543	R:R:?545	9.52	3	Yes	Yes	7	6	1	1
R:R:?543	R:R:?546	8.65	3	Yes	Yes	7	9	1	0
R:R:?543	R:R:I547	7.64	3	Yes	No	7	5	1	1
R:R:?545	R:R:?546	25.95	3	Yes	Yes	6	9	1	0
R:R:?545	R:R:?548	7.96	3	Yes	Yes	6	4	1	1
R:R:?545	R:R:I549	6.11	3	Yes	Yes	6	9	1	1
R:R:?546	R:R:I547	4.16	3	Yes	No	9	5	0	1
R:R:?546	R:R:?548	6.42	3	Yes	Yes	9	4	0	1
R:R:?546	R:R:I549	6.94	3	Yes	Yes	9	9	0	1
R:R:?546	R:R:?550	5.24	3	Yes	Yes	9	9	0	1
R:R:?546	R:R:M571	12.37	3	Yes	Yes	9	8	0	1
R:R:?546	R:R:L574	4.04	3	Yes	Yes	9	9	0	1
R:R:?546	R:R:I575	6.94	3	Yes	No	9	9	0	1
R:R:?546	R:R:?623	6.55	3	Yes	Yes	9	9	0	1
R:R:F551	R:R:I547	6.28	0	No	No	4	5	2	1
R:R:?548	R:R:?550	5.62	3	Yes	Yes	4	9	1	1
R:R:?550	R:R:I549	5.55	3	Yes	Yes	9	9	1	1
R:R:I549	R:R:M571	4.37	3	Yes	Yes	9	8	1	1
R:R:?550	R:R:F551	13.03	3	Yes	No	9	4	1	2
R:R:?550	R:R:D564	5.28	3	Yes	No	9	8	1	2
R:R:?550	R:R:M571	4.12	3	Yes	Yes	9	8	1	1
R:R:I567	R:R:M571	4.37	3	No	Yes	7	8	2	1
R:R:?570	R:R:L574	5.78	3	No	Yes	9	9	2	1
R:R:?623	R:R:L574	9.42	3	Yes	Yes	9	9	1	1
R:R:?543	R:R:A544	3.37	3	Yes	No	7	3	1	2
R:R:?545	R:R:A544	3.37	3	Yes	No	6	3	1	2
R:R:?545	R:R:L462	2.96	3	Yes	No	6	5	1	2
R:R:L574	R:R:L622	2.77	3	Yes	No	9	9	1	2
R:R:?548	R:R:A552	1.88	3	Yes	No	4	5	1	2

Statistics	Value
Average Number Of Links	11.00
Average Number Of Links With An Hub	8.00
Average Interaction Strength	9.24
Average Nodes In Shell	25.00
Average Hubs In Shell	11.00
Average Links In Shell	38.00
Average Links Mediated by Hubs In Shell	36.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TMR in 7FIH
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:?546	R:R:T461	14.34	3	Yes	No	9	8	1	2
R:R:?545	R:R:W465	8.54	3	Yes	Yes	6	5	2	2
R:R:?548	R:R:W465	4.08	3	Yes	Yes	4	5	1	2
R:R:I549	R:R:W465	4.7	3	Yes	Yes	9	5	1	2
R:R:I468	R:R:I549	5.89	0	No	Yes	7	9	2	1
R:R:?543	R:R:?545	9.52	3	Yes	Yes	7	6	2	2
R:R:?543	R:R:?546	8.65	3	Yes	Yes	7	9	2	1
R:R:?543	R:R:I547	7.64	3	Yes	No	7	5	2	2
R:R:?545	R:R:?546	25.95	3	Yes	Yes	6	9	2	1
R:R:?545	R:R:?548	7.96	3	Yes	Yes	6	4	2	1
R:R:?545	R:R:I549	6.11	3	Yes	Yes	6	9	2	1
R:R:?546	R:R:I547	4.16	3	Yes	No	9	5	1	2
R:R:?546	R:R:?548	6.42	3	Yes	Yes	9	4	1	1
R:R:?546	R:R:I549	6.94	3	Yes	Yes	9	9	1	1
R:R:?546	R:R:?550	5.24	3	Yes	Yes	9	9	1	0
R:R:?546	R:R:M571	12.37	3	Yes	Yes	9	8	1	1
R:R:?546	R:R:L574	4.04	3	Yes	Yes	9	9	1	2
R:R:?546	R:R:I575	6.94	3	Yes	No	9	9	1	2
R:R:?546	R:R:?623	6.55	3	Yes	Yes	9	9	1	2
R:R:F551	R:R:I547	6.28	0	No	No	4	5	1	2
R:R:?548	R:R:?550	5.62	3	Yes	Yes	4	9	1	0
R:R:?550	R:R:I549	5.55	3	Yes	Yes	9	9	0	1
R:R:I549	R:R:M571	4.37	3	Yes	Yes	9	8	1	1
R:R:?550	R:R:F551	13.03	3	Yes	No	9	4	0	1
R:R:?550	R:R:D564	5.28	3	Yes	No	9	8	0	1
R:R:?550	R:R:M571	4.12	3	Yes	Yes	9	8	0	1
R:R:D564	R:R:R554	8.34	0	No	No	8	5	1	2
R:R:A560	R:R:D564	4.63	0	No	No	3	8	2	1
R:R:I567	R:R:M571	4.37	3	No	Yes	7	8	2	1
R:R:?623	R:R:L574	9.42	3	Yes	Yes	9	9	2	2
R:R:?548	R:R:A552	1.88	3	Yes	No	4	5	1	2

Statistics	Value
Average Number Of Links	6.00
Average Number Of Links With An Hub	4.00
Average Interaction Strength	6.47
Average Nodes In Shell	20.00
Average Hubs In Shell	10.00
Average Links In Shell	31.00
Average Links Mediated by Hubs In Shell	28.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TMR in 7FIH
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F350	W:W:?801	6.26	0	No	Yes	8	0	2	1
R:R:I369	R:R:P613	5.08	0	No	No	8	9	2	1
R:R:?409	R:R:M408	3.7	6	Yes	No	9	8	2	1
R:R:?612	R:R:M408	9.62	6	Yes	No	7	8	0	1
R:R:M408	R:R:S616	4.6	0	No	Yes	8	9	1	2
R:R:?409	R:R:?411	9.39	6	Yes	Yes	9	7	2	2
R:R:?411	R:R:T446	11.47	6	Yes	No	7	8	2	2
R:R:?411	R:R:F515	5.92	6	Yes	Yes	7	9	2	1
R:R:F515	R:R:T446	5.19	6	Yes	No	9	8	1	2
R:R:?612	R:R:S450	7.3	6	Yes	No	7	8	0	1
R:R:F515	R:R:I513	8.79	6	Yes	No	9	9	1	2
R:R:I513	R:R:L608	8.56	6	No	No	9	8	2	2
R:R:?514	R:R:F515	3.91	6	Yes	Yes	9	9	2	1
R:R:F515	R:R:P516	4.33	6	Yes	No	9	9	1	2
R:R:F515	R:R:L608	3.65	6	Yes	No	9	8	1	2
R:R:?612	R:R:F515	10.66	6	Yes	Yes	7	9	0	1
R:R:F515	W:W:?801	12.52	6	Yes	Yes	9	0	1	1
R:R:P516	W:W:?801	6.03	6	No	Yes	9	0	2	1
R:R:M517	W:W:?801	21.8	0	No	Yes	8	0	2	1
R:R:I528	W:W:?801	5.24	0	No	Yes	6	0	2	1
R:R:A589	W:W:?801	6.94	0	No	Yes	9	0	2	1
R:R:A592	W:W:?801	4.63	0	No	Yes	9	0	2	1
R:R:P597	W:W:?801	6.03	0	No	Yes	5	0	2	1
R:R:V601	W:W:?801	5.47	0	No	Yes	8	0	2	1
R:R:S604	W:W:?801	9.92	0	No	Yes	6	0	2	1
R:R:?612	R:R:P613	19.17	6	Yes	No	7	9	0	1
R:R:?612	W:W:?801	3.95	6	Yes	Yes	7	0	0	1
R:R:P613	R:R:S616	5.34	0	No	Yes	9	9	1	2
R:R:V519	W:W:?801	3.28	0	No	Yes	6	0	2	1
R:R:A349	W:W:?801	2.31	0	No	Yes	8	0	2	1

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	10.14
Average Nodes In Shell	25.00
Average Hubs In Shell	7.00
Average Links In Shell	30.00
Average Links Mediated by Hubs In Shell	28.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TMR in 7FIH
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
A:A:?391	R:R:E463	5.16	3	Yes	No	4	9	2	2
A:A:?391	R:R:R464	8.27	3	Yes	Yes	4	8	2	1
R:R:?399	R:R:M398	4.54	15	Yes	No	8	7	2	1
R:R:?623	R:R:M398	8.25	3	Yes	No	9	7	0	1
R:R:A624	R:R:M398	4.83	0	No	No	7	7	2	1
R:R:I460	R:R:R464	5.01	0	No	Yes	9	8	2	1
R:R:?546	R:R:T461	14.34	3	Yes	No	9	8	1	2
R:R:E463	R:R:R464	8.14	3	No	Yes	9	8	2	1
R:R:?623	R:R:R464	7.09	3	Yes	Yes	9	8	0	1
R:R:?543	R:R:?545	9.52	3	Yes	Yes	7	6	2	2
R:R:?543	R:R:?546	8.65	3	Yes	Yes	7	9	2	1
R:R:?543	R:R:I547	7.64	3	Yes	No	7	5	2	2
R:R:?545	R:R:?546	25.95	3	Yes	Yes	6	9	2	1
R:R:?545	R:R:?548	7.96	3	Yes	Yes	6	4	2	2
R:R:?545	R:R:I549	6.11	3	Yes	Yes	6	9	2	2
R:R:?546	R:R:I547	4.16	3	Yes	No	9	5	1	2
R:R:?546	R:R:?548	6.42	3	Yes	Yes	9	4	1	2
R:R:?546	R:R:I549	6.94	3	Yes	Yes	9	9	1	2
R:R:?546	R:R:?550	5.24	3	Yes	Yes	9	9	1	2
R:R:?546	R:R:M571	12.37	3	Yes	Yes	9	8	1	2
R:R:?546	R:R:L574	4.04	3	Yes	Yes	9	9	1	1
R:R:?546	R:R:I575	6.94	3	Yes	No	9	9	1	2
R:R:?546	R:R:?623	6.55	3	Yes	Yes	9	9	1	0
R:R:?548	R:R:?550	5.62	3	Yes	Yes	4	9	2	2
R:R:?550	R:R:I549	5.55	3	Yes	Yes	9	9	2	2
R:R:I549	R:R:M571	4.37	3	Yes	Yes	9	8	2	2
R:R:?550	R:R:M571	4.12	3	Yes	Yes	9	8	2	2
R:R:?570	R:R:L574	5.78	3	No	Yes	9	9	2	1
R:R:?623	R:R:L574	9.42	3	Yes	Yes	9	9	0	1
R:R:L574	R:R:L622	2.77	3	Yes	No	9	9	1	2

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	3.00
Average Interaction Strength	7.83
Average Nodes In Shell	21.00
Average Hubs In Shell	12.00
Average Links In Shell	30.00
Average Links Mediated by Hubs In Shell	29.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TMR in 7FIH
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Shell	Node2Shell
L:L:F57	L:L:R59	8.55	1	No	No	2	1
L:L:?61	L:L:R59	4.73	1	Yes	No	0	1
L:L:R59	M:M:L128	4.86	1	No	No	1	1
L:L:A60	M:M:?79	4.6	0	No	Yes	2	1
L:L:?61	L:L:P62	14.37	1	Yes	No	0	1
L:L:?61	L:L:V77	7.24	1	Yes	No	0	1
L:L:?61	L:L:T78	12.9	1	Yes	No	0	1
L:L:?61	M:M:I53	4.16	1	Yes	No	0	1
L:L:?61	M:M:?79	3.93	1	Yes	Yes	0	1
L:L:?61	M:M:L128	8.08	1	Yes	No	0	1
L:L:P62	M:M:L36	4.93	0	No	No	1	2
L:L:N76	L:L:V77	7.39	0	No	No	2	1
L:L:V77	M:M:?79	7.24	1	No	Yes	1	1
L:L:T78	M:M:D119	5.78	0	No	Yes	1	2
M:M:A34	M:M:I53	4.87	0	No	No	2	1
M:M:?54	M:M:I53	9.17	1	Yes	No	2	1
M:M:?54	M:M:?79	4.32	1	Yes	Yes	2	1
M:M:?108	M:M:?54	9.52	1	Yes	Yes	2	2
M:M:?79	M:M:N78	6.68	1	Yes	Yes	1	2
M:M:?79	M:M:V82	5.8	1	Yes	No	1	2
M:M:?79	M:M:A105	4.6	1	Yes	No	1	2
M:M:?108	M:M:?79	14.42	1	Yes	Yes	2	1

Statistics	Value
Average Number Of Links	7.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	7.92
Average Nodes In Shell	19.00
Average Hubs In Shell	6.00
Average Links In Shell	22.00
Average Links Mediated by Hubs In Shell	17.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TMR in 7FIH
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:?126	R:R:E148	7.11	1	Yes	No	5	5	2	1
L:L:?89	R:R:E148	3.87	0	Yes	No	0	5	0	1
L:L:E101	R:R:N150	3.94	0	No	No	0	5	1	2
L:L:S88	L:L:T104	4.8	0	No	No	0	0	2	1
L:L:?89	L:L:N90	5.34	0	Yes	No	0	0	0	1
L:L:?89	L:L:E101	19.33	0	Yes	No	0	0	0	1
L:L:?89	L:L:T104	4.3	0	Yes	No	0	0	0	1
L:L:N102	L:L:N90	6.81	0	No	No	0	0	2	1
L:L:?99	L:L:E101	4.74	0	Yes	No	0	0	2	1

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	8.21
Average Nodes In Shell	10.00
Average Hubs In Shell	3.00
Average Links In Shell	9.00
Average Links Mediated by Hubs In Shell	6.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TMR in 7FIH
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:?77	R:R:E102	11.86	0	No	Yes	5	7	2	1
R:R:E102	R:R:L104	6.63	1	Yes	No	7	5	1	2
R:R:?127	R:R:E102	7.73	1	Yes	Yes	6	7	2	1
L:L:T110	R:R:E102	7.06	1	Yes	Yes	0	7	1	1
L:L:?112	R:R:E102	9.02	1	Yes	Yes	0	7	0	1
R:R:?127	R:R:L104	6.73	1	Yes	No	6	5	2	2
R:R:?126	R:R:L125	4.13	1	Yes	Yes	5	9	1	2
R:R:F151	R:R:L125	3.65	1	Yes	Yes	5	9	2	2
R:R:?126	R:R:?127	14.46	1	Yes	Yes	5	6	1	2
R:R:?126	R:R:E148	7.11	1	Yes	No	5	5	1	2
R:R:?126	R:R:F151	6.54	1	Yes	Yes	5	5	1	2
L:L:?112	R:R:?126	4.82	1	Yes	Yes	0	5	0	1
R:R:I152	R:R:T178	7.6	1	No	No	4	6	2	2
L:L:?113	R:R:I152	4.16	1	Yes	No	0	4	1	2
L:L:?113	R:R:T178	4.3	1	Yes	No	0	6	1	2
L:L:?113	R:R:?180	4.02	1	Yes	Yes	0	5	1	2
L:L:?111	L:L:?83	15.87	1	Yes	Yes	0	0	1	2
L:L:?83	M:M:Q74	9.98	1	Yes	Yes	0	0	2	1
L:L:S109	L:L:T110	4.8	0	No	Yes	0	0	2	1
L:L:?111	L:L:T110	7.89	1	Yes	Yes	0	0	1	1
L:L:?112	L:L:T110	7.17	1	Yes	Yes	0	0	0	1
L:L:T110	M:M:?122	5.14	1	Yes	Yes	0	0	1	2
L:L:?111	L:L:?112	30.27	1	Yes	Yes	0	0	1	0
L:L:?111	L:L:H114	22.03	1	Yes	Yes	0	0	1	1
L:L:?111	M:M:Q74	12.83	1	Yes	Yes	0	0	1	1
L:L:?112	L:L:?113	24.88	1	Yes	Yes	0	0	0	1
L:L:?112	L:L:H114	12.5	1	Yes	Yes	0	0	0	1
L:L:?112	M:M:Q74	5.18	1	Yes	Yes	0	0	0	1
L:L:?113	L:L:H114	7.5	1	Yes	Yes	0	0	1	1
L:L:?113	M:M:A71	10.73	1	Yes	No	0	0	1	2
L:L:?113	M:M:Q74	19.42	1	Yes	Yes	0	0	1	1
L:L:?115	L:L:H114	12.27	1	Yes	Yes	0	0	2	1
L:L:H114	M:M:?113	5.51	1	Yes	Yes	0	0	1	2
L:L:H114	M:M:?120	12.39	1	Yes	Yes	0	0	1	2
L:L:?115	M:M:?113	7.96	1	Yes	Yes	0	0	2	2
M:M:?113	M:M:?120	11.11	1	Yes	Yes	0	0	2	2

Statistics	Value
Average Number Of Links	7.00
Average Number Of Links With An Hub	7.00
Average Interaction Strength	13.41
Average Nodes In Shell	24.00
Average Hubs In Shell	17.00
Average Links In Shell	36.00
Average Links Mediated by Hubs In Shell	35.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TMR in 7FIH
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:T110	R:R:E102	7.06	1	Yes	Yes	0	7	2	2
L:L:?112	R:R:E102	9.02	1	Yes	Yes	0	7	1	2
L:L:?112	R:R:?126	4.82	1	Yes	Yes	0	5	1	2
R:R:I152	R:R:T178	7.6	1	No	No	4	6	1	1
L:L:?113	R:R:I152	4.16	1	Yes	No	0	4	0	1
L:L:?113	R:R:T178	4.3	1	Yes	No	0	6	0	1
R:R:?180	R:R:L181	4.95	1	Yes	Yes	5	8	1	2
R:R:?180	R:R:?182	4.02	1	Yes	Yes	5	6	1	2
R:R:?180	R:R:E203	5.53	1	Yes	No	5	5	1	2
L:L:?113	R:R:?180	4.02	1	Yes	Yes	0	5	0	1
R:R:?182	R:R:E203	19.33	1	Yes	No	6	5	2	2
L:L:?111	L:L:?83	15.87	1	Yes	Yes	0	0	2	2
L:L:?83	M:M:Q74	9.98	1	Yes	Yes	0	0	2	1
L:L:?111	L:L:T110	7.89	1	Yes	Yes	0	0	2	2
L:L:?112	L:L:T110	7.17	1	Yes	Yes	0	0	1	2
L:L:?111	L:L:?112	30.27	1	Yes	Yes	0	0	2	1
L:L:?111	L:L:H114	22.03	1	Yes	Yes	0	0	2	1
L:L:?111	M:M:Q74	12.83	1	Yes	Yes	0	0	2	1
L:L:?112	L:L:?113	24.88	1	Yes	Yes	0	0	1	0
L:L:?112	L:L:H114	12.5	1	Yes	Yes	0	0	1	1
L:L:?112	M:M:Q74	5.18	1	Yes	Yes	0	0	1	1
L:L:?113	L:L:H114	7.5	1	Yes	Yes	0	0	0	1
L:L:?113	M:M:A71	10.73	1	Yes	No	0	0	0	1
L:L:?113	M:M:Q74	19.42	1	Yes	Yes	0	0	0	1
L:L:?115	L:L:H114	12.27	1	Yes	Yes	0	0	2	1
L:L:H114	M:M:?113	5.51	1	Yes	Yes	0	0	1	2
L:L:H114	M:M:?120	12.39	1	Yes	Yes	0	0	1	2
L:L:?115	M:M:?113	7.96	1	Yes	Yes	0	0	2	2
M:M:?113	M:M:?120	11.11	1	Yes	Yes	0	0	2	2

Statistics	Value
Average Number Of Links	7.00
Average Number Of Links With An Hub	4.00
Average Interaction Strength	10.72
Average Nodes In Shell	19.00
Average Hubs In Shell	15.00
Average Links In Shell	29.00
Average Links Mediated by Hubs In Shell	28.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TMR in 7FIH
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Shell	Node2Shell
L:L:Q29	M:M:R28	5.84	0	No	Yes	2	1
L:L:?31	L:L:D30	11.63	1	Yes	No	1	2
L:L:?31	L:L:P32	15.83	1	Yes	No	1	2
L:L:?31	L:L:?55	12.7	1	Yes	Yes	1	1
L:L:?31	M:M:R26	13.01	1	Yes	Yes	1	1
L:L:?31	M:M:?57	7.21	1	Yes	Yes	1	0
L:L:E33	M:M:L25	3.98	1	No	No	2	2
L:L:E33	M:M:R26	22.1	1	No	Yes	2	1
L:L:?34	L:L:?54	12.93	1	Yes	No	2	2
L:L:?34	L:L:?55	6.35	1	Yes	Yes	2	1
L:L:?54	L:L:?55	18.1	1	No	Yes	2	1
L:L:?55	L:L:?56	28.57	1	Yes	No	1	1
L:L:?55	M:M:?57	8.65	1	Yes	Yes	1	0
L:L:?55	M:M:?58	9.52	1	Yes	Yes	1	1
L:L:?108	L:L:?56	9.52	1	Yes	No	2	1
L:L:?56	M:M:?57	34.6	1	No	Yes	1	0
L:L:F57	L:L:R59	8.55	1	No	No	1	2
L:L:F57	M:M:?56	5.31	1	No	No	1	1
L:L:F57	M:M:?57	7.11	1	No	Yes	1	0
M:M:L25	M:M:R26	4.86	1	No	Yes	2	1
M:M:?57	M:M:R26	7.09	1	Yes	Yes	0	1
M:M:?29	M:M:R28	6.5	1	Yes	Yes	1	1
M:M:?57	M:M:R28	5.91	1	Yes	Yes	0	1
M:M:?58	M:M:R28	5.2	1	Yes	Yes	1	1
M:M:P59	M:M:R28	5.76	1	No	Yes	2	1
M:M:?29	M:M:R30	5.2	1	Yes	Yes	1	2
M:M:?29	M:M:?56	7.76	1	Yes	No	1	1
M:M:?29	M:M:?57	10.09	1	Yes	Yes	1	0
M:M:?29	M:M:?77	15.87	1	Yes	Yes	1	2
M:M:?108	M:M:?29	7.94	1	Yes	Yes	2	1
M:M:?56	M:M:?57	23.48	1	No	Yes	1	0
M:M:?57	M:M:?58	24.51	1	Yes	Yes	0	1
M:M:?58	M:M:P59	19.34	1	Yes	No	1	2
M:M:?58	M:M:T60	4.74	1	Yes	No	1	2
M:M:?110	M:M:?58	9.52	0	Yes	Yes	2	1
M:M:?110	M:M:?77	11.11	0	Yes	Yes	2	2

Statistics	Value
Average Number Of Links	9.00
Average Number Of Links With An Hub	6.00
Average Interaction Strength	14.29
Average Nodes In Shell	25.00
Average Hubs In Shell	13.00
Average Links In Shell	36.00
Average Links Mediated by Hubs In Shell	33.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TMR in 7FIH
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Shell	Node2Shell
L:L:?61	L:L:R59	4.73	1	Yes	No	1	2
L:L:R59	M:M:L128	4.86	1	No	No	2	2
L:L:A60	M:M:?79	4.6	0	No	Yes	1	0
L:L:?61	L:L:P62	14.37	1	Yes	No	1	2
L:L:?61	L:L:V77	7.24	1	Yes	No	1	1
L:L:?61	L:L:T78	12.9	1	Yes	No	1	2
L:L:?61	M:M:I53	4.16	1	Yes	No	1	2
L:L:?61	M:M:?79	3.93	1	Yes	Yes	1	0
L:L:?61	M:M:L128	8.08	1	Yes	No	1	2
L:L:N76	L:L:V77	7.39	0	No	No	2	1
L:L:V77	M:M:?79	7.24	1	No	Yes	1	0
M:M:?29	M:M:?77	15.87	1	Yes	Yes	2	2
M:M:?108	M:M:?29	7.94	1	Yes	Yes	1	2
M:M:?54	M:M:I53	9.17	1	Yes	No	1	2
M:M:?54	M:M:A55	5.06	1	Yes	No	1	2
M:M:?54	M:M:?77	6.35	1	Yes	Yes	1	2
M:M:?54	M:M:?79	4.32	1	Yes	Yes	1	0
M:M:?108	M:M:?54	9.52	1	Yes	Yes	1	1
M:M:?77	M:M:V76	12.76	1	Yes	Yes	2	2
M:M:N78	M:M:V76	4.43	1	Yes	Yes	1	2
M:M:?113	M:M:V76	4.79	1	Yes	Yes	2	2
M:M:?77	M:M:N78	11.76	1	Yes	Yes	2	1
M:M:?79	M:M:N78	6.68	1	Yes	Yes	0	1
M:M:?113	M:M:N78	4.41	1	Yes	Yes	2	1
M:M:N78	M:M:T118	4.39	1	Yes	No	1	2
M:M:?79	M:M:V82	5.8	1	Yes	No	0	1
M:M:?79	M:M:A105	4.6	1	Yes	No	0	1
M:M:?108	M:M:?79	14.42	1	Yes	Yes	1	0
M:M:?108	M:M:R80	11.71	1	Yes	No	1	2
M:M:Q109	M:M:R80	4.67	1	Yes	No	2	2
M:M:?108	M:M:Q109	5.7	1	Yes	Yes	1	2
M:M:?113	M:M:T118	6.31	1	Yes	No	2	2
M:M:A105	M:M:T52	3.36	0	No	No	1	2

Statistics	Value
Average Number Of Links	8.00
Average Number Of Links With An Hub	4.00
Average Interaction Strength	6.45
Average Nodes In Shell	24.00
Average Hubs In Shell	10.00
Average Links In Shell	33.00
Average Links Mediated by Hubs In Shell	30.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of TMR in 7FIH
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Shell	Node2Shell
M:M:V38	M:M:V49	6.41	12	No	No	1	1
M:M:?102	M:M:V38	4.35	12	Yes	No	0	1
M:M:?102	M:M:V49	5.8	12	Yes	No	0	1
M:M:?102	M:M:T51	8.6	12	Yes	No	0	1
M:M:T51	M:M:V104	4.76	12	No	Yes	1	1
M:M:T52	M:M:V104	4.76	0	No	Yes	2	1
M:M:E85	M:M:R83	4.65	12	No	No	1	2
M:M:R83	M:M:V104	5.23	12	No	Yes	2	1
M:M:?102	M:M:F84	7.11	12	Yes	No	0	1
M:M:?102	M:M:E85	21.91	12	Yes	No	0	1
M:M:E85	M:M:V104	7.13	12	No	Yes	1	1
M:M:?102	M:M:S101	4.38	12	Yes	No	0	1
M:M:?102	M:M:V104	4.35	12	Yes	Yes	0	1
M:M:I47	M:M:V38	3.07	0	No	No	2	1
M:M:?102	M:M:A103	3.06	12	Yes	No	0	1

Statistics	Value
Average Number Of Links	8.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	7.45
Average Nodes In Shell	12.00
Average Hubs In Shell	2.00
Average Links In Shell	15.00
Average Links Mediated by Hubs In Shell	12.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Statistics	Value
Average Number Of Links	6.30
Average Number Of Links With An Hub	2.47
Average Interaction Strength	10.30
Average Nodes In Shell	16.67
Average Hubs In Shell	6.66
Average Links In Shell	21.21
Average Links Mediated by Hubs In Shell	18.31

Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

Location of the nodes interacting with this ligand

(Click to enlarge 🔍)