psnGPCR

Press and hold down the left mouse button and move the mouse to rotate.
Press and hold down the central mouse button and move the mouse to translate.
Use the mouse wheel to zoom in or out.
Click on any atom on your molecule and the corresponding residue label will be placed beneath the viewer.

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E74	R:R:T52	5.64	No	No	0	4	3
2	R:R:?77	R:R:R53	4.35	No	No	0	5	2
3	R:R:L56	R:R:L59	5.54	No	Yes	0	6	7
4	R:R:?58	R:R:A57	6.13	Yes	No	0	5	4
5	R:R:?58	R:R:L59	8.08	Yes	Yes	0	5	7
6	R:R:?58	R:R:Q82	15.53	Yes	Yes	0	5	6
7	N:N:?124	R:R:?58	5.62	Yes	Yes	0	0	5
8	R:R:L59	R:R:V61	4.47	Yes	No	0	7	6
9	R:R:?62	R:R:V63	5.33	No	No	0	4	4
10	R:R:?62	R:R:E87	8.7	No	No	0	4	5
11	R:R:I64	R:R:L86	7.14	No	No	0	7	8
12	R:R:I64	R:R:I89	4.42	No	No	0	7	8
13	R:R:E90	R:R:S66	4.31	No	No	0	6	4
14	R:R:N92	R:R:S66	4.47	Yes	No	0	6	4
15	R:R:Q67	R:R:R70	11.68	No	No	0	3	2
16	R:R:D95	R:R:Q67	13.05	No	No	0	6	3
17	R:R:F69	R:R:F94	6.43	No	No	0	8	9
18	R:R:?71	R:R:L72	6.04	No	No	0	5	7
19	R:R:L72	R:R:V75	5.96	No	No	0	7	7
20	R:R:L98	R:R:N73	10.98	No	No	0	6	4
21	R:R:?77	R:R:E102	11.86	No	Yes	0	5	7
22	R:R:I78	R:R:L100	7.14	No	No	0	8	9
23	R:R:E79	R:R:S81	8.62	No	No	0	5	6
24	R:R:I80	R:R:I83	5.89	No	No	0	8	7
25	R:R:I105	R:R:I80	8.83	No	No	0	8	8
26	R:R:Q82	R:R:S81	5.78	Yes	No	0	6	6
27	R:R:N107	R:R:Q82	7.92	No	Yes	0	7	6
28	L:L:T70	R:R:Q82	4.25	No	Yes	0	0	6
29	L:L:T70	R:R:D84	14.45	No	No	0	0	7
30	R:R:L86	R:R:T108	4.42	No	No	0	8	8
31	R:R:E87	R:R:R112	9.3	No	No	0	5	5
32	R:R:?113	R:R:R88	4.73	Yes	No	0	1	1
33	R:R:E115	R:R:R88	11.63	No	No	0	5	1
34	R:R:I114	R:R:I89	5.89	No	No	0	8	8
35	R:R:D95	R:R:N92	8.08	No	Yes	6	6	6
36	R:R:?117	R:R:N92	4.79	Yes	Yes	6	3	6
37	R:R:I120	R:R:N92	4.25	Yes	Yes	6	5	6
38	R:R:F119	R:R:F94	10.72	No	No	0	8	9
39	R:R:D95	R:R:I120	5.6	No	Yes	6	6	5
40	R:R:L100	R:R:L97	8.3	No	No	0	9	8
41	R:R:L98	R:R:N99	5.49	No	No	0	6	5
42	R:R:I103	R:R:L100	7.14	No	No	0	8	9
43	R:R:E102	R:R:L104	6.63	Yes	No	1	7	5
44	R:R:?127	R:R:E102	7.73	Yes	Yes	1	6	7
45	L:L:T110	R:R:E102	7.06	Yes	Yes	1	0	7
46	L:L:?112	R:R:E102	9.02	Yes	Yes	1	0	7
47	R:R:I103	R:R:L125	4.28	No	Yes	0	8	9
48	R:R:?127	R:R:L104	6.73	Yes	No	1	6	5
49	R:R:N107	R:R:Q106	7.92	No	No	0	7	7
50	N:N:D119	R:R:Q106	6.53	Yes	No	0	0	7
51	N:N:?121	R:R:Q106	4.64	No	No	0	0	7
52	L:L:M71	R:R:N107	8.41	No	No	0	0	7
53	R:R:L111	R:R:T108	7.37	Yes	No	0	7	8
54	R:R:?109	R:R:N110	8.19	No	No	0	6	5
55	R:R:?109	R:R:?134	4.32	No	No	0	6	5
56	L:L:L72	R:R:?109	6.61	No	No	0	0	6
57	R:R:?113	R:R:L111	10.77	Yes	Yes	9	1	7
58	R:R:I114	R:R:L111	5.71	No	Yes	9	8	7
59	R:R:I135	R:R:L111	7.14	Yes	Yes	9	7	7
60	R:R:?113	R:R:R112	13	Yes	No	0	1	5
61	R:R:?113	R:R:I114	5.55	Yes	No	9	1	8
62	R:R:?113	R:R:I135	5.55	Yes	Yes	9	1	7
63	R:R:?117	R:R:P116	4.3	Yes	No	6	3	4
64	R:R:D140	R:R:P116	4.83	No	No	6	3	4
65	R:R:?117	R:R:I120	4.98	Yes	Yes	6	3	5
66	R:R:?117	R:R:D140	4.73	Yes	No	6	3	3
67	R:R:F119	R:R:L128	4.87	No	No	0	8	8
68	R:R:?143	R:R:I120	7.66	No	Yes	0	4	5
69	R:R:L122	R:R:L125	5.54	No	Yes	0	8	9
70	R:R:L125	R:R:V144	5.96	Yes	No	0	9	7
71	R:R:?126	R:R:?127	14.46	Yes	Yes	0	5	6
72	R:R:?126	R:R:E148	7.11	Yes	No	0	5	5
73	R:R:?126	R:R:F151	6.54	Yes	No	0	5	5
74	L:L:?112	R:R:?126	4.82	Yes	Yes	0	0	5
75	R:R:?127	R:R:S129	8.76	Yes	No	1	6	7
76	R:R:?127	R:R:E154	9.02	Yes	Yes	1	6	7
77	R:R:E154	R:R:S129	14.37	Yes	No	1	7	7
78	R:R:I130	R:R:T133	4.56	No	Yes	0	8	8
79	R:R:?131	R:R:N132	11.76	Yes	Yes	1	7	8
80	R:R:?131	R:R:T133	6.31	Yes	Yes	0	7	8
81	R:R:?131	R:R:?156	31.75	Yes	Yes	1	7	7
82	R:R:?131	R:R:D157	4.36	Yes	Yes	1	7	6
83	R:R:D157	R:R:N132	12.12	Yes	Yes	1	6	8
84	L:L:L72	R:R:N132	5.49	No	Yes	0	0	8
85	L:L:V73	R:R:N132	7.39	No	Yes	0	0	8
86	R:R:I135	R:R:T133	7.6	Yes	Yes	0	7	8
87	R:R:N158	R:R:T133	10.24	Yes	Yes	0	9	8
88	R:R:?134	R:R:R136	6.36	No	No	0	5	3
89	R:R:?137	R:R:I135	4.26	No	Yes	0	3	7
90	R:R:H160	R:R:R136	16.93	No	No	0	3	3
91	R:R:F138	R:R:P139	14.45	Yes	No	0	5	9
92	R:R:F138	R:R:I155	5.02	Yes	No	0	5	8
93	R:R:F138	R:R:I164	5.02	Yes	No	0	5	7
94	R:R:F138	R:R:P165	10.11	Yes	No	0	5	7
95	R:R:D140	R:R:T142	7.23	No	No	0	3	4
96	R:R:?143	R:R:F145	14.53	No	No	0	4	3
97	R:R:?171	R:R:F145	9.56	No	No	0	4	3
98	R:R:N173	R:R:S146	8.94	No	No	0	4	7
99	R:R:N150	R:R:S149	4.47	No	No	0	5	3
100	R:R:E175	R:R:S149	8.62	No	No	0	5	3
101	L:L:?99	R:R:S149	4.48	Yes	No	0	0	3
102	N:N:Q66	R:R:N150	14.52	No	No	0	0	5
103	R:R:F151	R:R:M172	8.71	No	No	11	5	6
104	R:R:F151	R:R:V177	5.24	No	Yes	11	5	3
105	R:R:I152	R:R:T178	7.6	No	No	0	4	6
106	R:R:?156	R:R:E154	4.26	Yes	Yes	1	7	7
107	L:L:?115	R:R:E154	6.32	Yes	Yes	1	0	7
108	R:R:I155	R:R:L181	4.28	No	No	0	8	8
109	R:R:I155	R:R:N184	7.08	No	Yes	0	8	9
110	R:R:?156	R:R:D157	14.53	Yes	Yes	1	7	6
111	R:R:?156	R:R:N158	13.23	Yes	Yes	1	7	9
112	R:R:?156	R:R:?182	4.32	Yes	Yes	1	7	6
113	R:R:?156	R:R:N184	13.23	Yes	Yes	1	7	9
114	N:N:R115	R:R:D157	8.34	No	Yes	1	0	6
115	R:R:I161	R:R:N158	8.5	No	Yes	0	7	9
116	R:R:N158	R:R:N184	5.45	Yes	Yes	1	9	9
117	R:R:F186	R:R:I161	5.02	Yes	No	0	8	7
118	R:R:F186	R:R:I164	15.07	Yes	No	0	8	7
119	R:R:I164	R:R:V189	6.14	No	No	0	7	7
120	R:R:?166	R:R:Q190	8.13	No	No	0	4	2
121	R:R:N167	R:R:N195	12.26	No	No	0	7	5
122	R:R:A168	R:R:F169	5.55	No	No	0	7	6
123	R:R:F169	R:R:L179	4.87	No	No	0	6	8
124	R:R:F169	R:R:F194	5.36	No	No	0	6	9
125	R:R:?171	R:R:Q170	9.29	No	No	0	4	3
126	R:R:M172	R:R:V177	6.09	No	Yes	11	6	3
127	R:R:S176	R:R:T198	4.8	No	No	0	5	5
128	R:R:L179	R:R:V177	4.47	No	Yes	0	8	3
129	R:R:T197	R:R:V177	6.35	No	Yes	0	5	3
130	L:L:?113	R:R:T178	4.3	Yes	No	0	0	6
131	R:R:L179	R:R:L199	6.92	No	No	0	8	8
132	R:R:?180	R:R:L181	4.95	No	No	0	5	8
133	R:R:?180	R:R:E203	5.53	No	No	0	5	5
134	R:R:F186	R:R:L181	4.87	Yes	No	0	8	8
135	R:R:?182	R:R:?183	15.26	Yes	Yes	1	6	7
136	R:R:?182	R:R:N184	9.35	Yes	Yes	1	6	9
137	R:R:?182	R:R:E203	19.33	Yes	No	0	6	5
138	R:R:?182	R:R:?205	13.65	Yes	No	0	6	7
139	N:N:R115	R:R:?182	11.82	No	Yes	1	0	6
140	R:R:?183	R:R:N184	4.79	Yes	Yes	1	7	9
141	R:R:?183	R:R:N207	5.99	Yes	No	0	7	9
142	N:N:R115	R:R:?183	5.3	No	Yes	1	0	7
143	R:R:F186	R:R:N184	14.5	Yes	Yes	0	8	9
144	R:R:?185	R:R:F186	4.25	No	Yes	0	4	8
145	R:R:?185	R:R:H209	5.61	No	No	0	4	1
146	R:R:F186	R:R:N207	7.25	Yes	No	0	8	9
147	R:R:M213	R:R:V189	4.56	No	No	0	6	7
148	R:R:H192	R:R:S191	9.76	No	No	0	5	5
149	R:R:H214	R:R:S191	11.16	No	No	12	5	5
150	R:R:?216	R:R:S191	5.24	Yes	No	12	3	5
151	R:R:H192	R:R:R219	6.77	No	No	0	5	1
152	R:R:F194	R:R:L199	8.53	No	No	0	9	8
153	R:R:F194	R:R:L202	9.74	No	Yes	0	9	7
154	R:R:?196	R:R:N195	8.38	No	No	0	6	5
155	R:R:?220	R:R:N195	8.38	No	No	0	5	5
156	R:R:?196	R:R:T197	9	No	No	0	6	5
157	R:R:T198	R:R:T222	6.28	No	No	0	5	3
158	R:R:E203	R:R:S201	4.31	No	No	0	5	5
159	R:R:S201	R:R:T226	4.8	No	No	0	5	4
160	R:R:L202	R:R:L204	8.3	Yes	No	0	7	9
161	R:R:L202	R:R:P224	4.93	Yes	No	0	7	8
162	R:R:?205	R:R:E206	4.74	No	No	0	7	4
163	R:R:?205	R:R:D228	5.67	No	No	0	7	9
164	R:R:E206	R:R:S231	5.75	No	No	0	4	6
165	R:R:L210	R:R:T232	4.42	No	No	0	8	9
166	R:R:?233	R:R:E211	7.91	No	No	0	3	2
167	R:R:L234	R:R:M213	8.48	No	No	0	7	6
168	R:R:?216	R:R:H214	5.61	Yes	No	12	3	5
169	R:R:N215	R:R:S239	4.47	No	No	0	1	4
170	R:R:?216	R:R:R219	8.48	Yes	No	0	3	1
171	R:R:F218	R:R:P224	11.56	No	No	0	8	8
172	R:R:F218	R:R:P238	7.22	No	No	0	8	9
173	R:R:?240	R:R:F218	4.74	Yes	No	0	2	8
174	R:R:?240	R:R:R219	20.09	Yes	No	0	2	1
175	R:R:?223	R:R:P224	10.02	No	No	0	7	8
176	R:R:?223	R:R:S244	9.17	No	No	0	7	4
177	R:R:?225	R:R:Q246	7.15	No	No	0	3	6
178	R:R:R247	R:R:T226	9.06	No	No	0	5	4
179	R:R:I229	R:R:L227	8.56	No	No	0	7	8
180	R:R:I245	R:R:L227	5.71	No	No	0	8	8
181	R:R:D228	R:R:S230	4.42	No	No	0	9	9
182	R:R:D228	R:R:I249	8.4	No	No	0	9	5
183	R:R:I229	R:R:T232	6.08	No	No	0	7	9
184	R:R:S230	R:R:T251	4.8	No	No	13	9	4
185	R:R:S230	R:R:S252	4.89	No	No	13	9	7
186	R:R:?233	R:R:S255	8.06	No	No	0	3	4
187	R:R:L237	R:R:L256	5.54	No	No	0	7	8
188	R:R:L237	R:R:P260	8.21	No	No	0	7	6
189	R:R:?240	R:R:?241	23.48	Yes	No	0	2	7
190	R:R:?241	R:R:L242	4.83	No	No	0	7	9
191	R:R:?241	R:R:E243	5.78	No	No	0	7	3
192	R:R:E243	R:R:T264	4.23	No	No	0	3	4
193	R:R:I245	R:R:L248	4.28	No	No	0	8	9
194	R:R:N267	R:R:Q246	10.56	No	No	0	4	6
195	R:R:E270	R:R:R247	9.3	No	No	0	6	5
196	N:N:P70	R:R:R247	11.53	No	No	0	0	5
197	R:R:S252	R:R:T251	6.4	No	No	13	7	4
198	R:R:L256	R:R:S253	6.01	No	No	0	8	7
199	R:R:?254	R:R:S255	4.38	No	No	0	2	4
200	R:R:?254	R:R:T274	5.73	No	No	14	2	9
201	R:R:?254	R:R:?275	20.95	No	Yes	14	2	8
202	R:R:?257	R:R:?258	6.9	No	No	0	7	5
203	R:R:?257	R:R:H278	5.37	No	No	0	7	9
204	R:R:?257	R:R:I431	6.81	No	No	0	7	8
205	R:R:?258	R:R:L259	4.95	No	Yes	0	5	6
206	R:R:H278	R:R:L259	9	No	Yes	0	9	6
207	R:R:P260	R:R:T264	5.25	No	No	0	6	4
208	R:R:F265	R:R:P260	8.67	No	No	0	7	6
209	R:R:E263	R:R:S261	5.75	No	No	0	4	4
210	R:R:N284	R:R:R262	8.44	No	No	0	5	5
211	R:R:F265	R:R:L268	12.18	No	No	15	7	6
212	R:R:F265	R:R:F282	4.29	No	Yes	15	7	8
213	R:R:N267	R:R:V266	7.39	No	No	0	4	4
214	R:R:A271	R:R:L268	4.73	No	No	0	7	6
215	R:R:F282	R:R:L268	6.09	Yes	No	15	8	6
216	R:R:L269	R:R:L337	8.3	No	No	0	4	3
217	R:R:L269	R:R:P338	6.57	No	No	0	4	3
218	R:R:E270	R:R:R342	9.3	No	No	0	6	4
219	R:R:?275	R:R:T274	11.47	Yes	No	14	8	9
220	R:R:?275	R:R:P276	14.37	Yes	No	0	8	7
221	R:R:?275	R:R:H278	18.76	Yes	No	0	8	9
222	R:R:?275	R:R:I431	20.82	Yes	No	0	8	8
223	R:R:?427	R:R:I277	6.94	Yes	No	4	7	8
224	R:R:A430	R:R:I277	4.87	No	No	4	9	8
225	R:R:?279	R:R:?280	26.98	No	Yes	0	9	9
226	R:R:?279	R:R:F282	6.52	No	Yes	0	9	8
227	R:R:?279	R:R:?343	17.46	No	No	0	9	9
228	R:R:?280	R:R:R283	5.2	Yes	Yes	4	9	3
229	R:R:?280	R:R:?353	15.87	Yes	No	4	9	9
230	R:R:?280	R:R:?427	4.32	Yes	Yes	4	9	7
231	R:R:?427	R:R:A281	9.19	Yes	No	0	7	8
232	R:R:F282	R:R:P341	5.78	Yes	No	0	8	6
233	R:R:E346	R:R:R283	11.63	No	Yes	4	4	3
234	R:R:P347	R:R:R283	4.32	No	Yes	4	8	3
235	R:R:?353	R:R:R283	5.2	No	Yes	4	9	3
236	R:R:L285	R:R:P286	4.93	No	No	0	4	4
237	R:R:?331	R:R:D330	11.88	Yes	No	0	1	4
238	R:R:?331	R:R:E332	6.44	Yes	No	0	1	4
239	R:R:?331	R:R:?333	6.55	Yes	No	0	1	1
240	R:R:?333	R:R:?334	11.74	No	No	0	1	3
241	R:R:?334	R:R:F335	11.68	No	No	0	3	1
242	R:R:?336	R:R:L337	5.93	No	No	0	6	3
243	R:R:?339	R:R:T340	4.4	No	No	0	3	4
244	R:R:E346	R:R:P347	7.86	No	No	4	4	8
245	R:R:?510	R:R:F350	7.99	No	No	0	6	8
246	R:R:F350	W:W:?801	6.26	No	Yes	0	8	0
247	R:R:E354	R:R:P352	11	Yes	No	0	7	9
248	R:R:P352	R:R:V601	7.07	No	No	0	9	8
249	R:R:?353	R:R:E354	4.26	No	Yes	0	9	7
250	R:R:E354	R:R:T602	8.47	Yes	No	0	7	7
251	R:R:?605	R:R:E354	4.74	No	Yes	0	9	7
252	R:R:?424	R:R:D355	10.65	No	No	0	7	7
253	R:R:D419	R:R:I356	7	No	No	0	9	8
254	R:R:I356	R:R:W433	4.7	No	No	0	8	9
255	R:R:D419	R:R:M357	9.7	No	No	0	9	7
256	R:R:?358	R:R:?359	23.48	No	Yes	0	8	6
257	R:R:?359	R:R:D360	7.92	Yes	No	0	6	4
258	R:R:?359	R:R:F361	8.29	Yes	No	16	6	5
259	R:R:?359	R:R:L362	9.42	Yes	Yes	16	6	8
260	R:R:?359	R:R:N603	10.68	Yes	No	0	6	6
261	R:R:F361	R:R:L362	8.53	No	Yes	16	5	8
262	R:R:L362	R:R:V606	4.47	Yes	No	0	8	7
263	R:R:L362	R:R:V609	8.94	Yes	No	0	8	9
264	R:R:D419	R:R:R363	16.68	No	No	0	9	9
265	R:R:I366	R:R:L412	4.28	No	No	0	9	8
266	R:R:N370	R:R:W367	7.91	No	No	0	6	9
267	R:R:A416	R:R:W367	7.78	No	No	0	9	9
268	R:R:I369	R:R:P613	5.08	No	No	0	8	9
269	R:R:L413	R:R:N370	12.36	No	No	0	6	6
270	R:R:I371	R:R:M375	4.37	No	No	0	4	2
271	R:R:?617	R:R:L372	4.45	Yes	No	0	9	5
272	R:R:?409	R:R:I374	4.98	Yes	No	0	9	5
273	R:R:?376	R:R:T379	10.28	No	No	0	7	4
274	R:R:?376	R:R:V380	5.2	No	No	0	7	9
275	R:R:N377	R:R:S402	8.94	No	Yes	0	9	8
276	R:R:D405	R:R:N377	9.42	Yes	No	0	9	9
277	R:R:N377	R:R:P620	11.4	No	No	0	9	9
278	R:R:S402	R:R:V380	6.46	Yes	No	0	8	9
279	R:R:A624	R:R:V380	5.09	No	No	0	7	9
280	R:R:?399	R:R:L381	7.41	Yes	No	7	8	5
281	R:R:L381	R:R:S402	9.01	No	Yes	7	5	8
282	R:R:F630	R:R:V383	11.8	Yes	No	0	8	7
283	R:R:?399	R:R:L384	5.93	Yes	No	0	8	6
284	R:R:F630	R:R:L384	4.87	Yes	No	0	8	6
285	R:R:L637	R:R:T386	4.42	No	No	0	7	5
286	R:R:?389	R:R:S387	13.14	Yes	No	0	3	7
287	R:R:R395	R:R:S387	6.59	No	No	0	7	7
288	R:R:D633	R:R:S387	7.36	No	No	0	8	7
289	R:R:?389	R:R:R388	5.91	Yes	No	0	3	5
290	R:R:?389	R:R:?390	13.65	Yes	No	0	3	4
291	R:R:?389	R:R:R632	9.45	Yes	No	0	3	6
292	R:R:?390	R:R:L391	5.78	No	No	0	4	5
293	R:R:L391	R:R:L480	6.92	No	No	0	5	3
294	R:R:P394	R:R:T392	5.25	No	No	0	6	8
295	R:R:P394	R:R:V393	5.3	No	No	0	6	8
296	R:R:A483	R:R:V393	5.09	No	No	0	7	8
297	R:R:R395	R:R:T629	6.47	No	No	0	7	6
298	R:R:F396	R:R:N400	13.29	No	Yes	7	7	7
299	R:R:F396	R:R:I484	7.54	No	No	0	7	3
300	R:R:F396	R:R:M487	4.98	No	No	7	7	7
301	R:R:I460	R:R:L397	7.14	No	No	0	9	7
302	R:R:?399	R:R:M398	4.54	Yes	No	0	8	7
303	R:R:?623	R:R:M398	8.25	Yes	No	0	9	7
304	R:R:A624	R:R:M398	4.83	No	No	0	7	7
305	R:R:?399	R:R:N400	10.29	Yes	Yes	7	8	7
306	R:R:?399	R:R:S402	4.82	Yes	Yes	7	8	8
307	R:R:M487	R:R:N400	8.41	No	Yes	7	7	7
308	R:R:N400	R:R:W491	4.52	Yes	No	0	7	5
309	R:R:L401	R:R:T456	7.37	No	No	0	8	8
310	R:R:L401	R:R:L457	6.92	No	No	17	8	9
311	R:R:L401	R:R:N619	12.36	No	Yes	17	8	9
312	R:R:?407	R:R:F403	5.22	Yes	No	0	7	5
313	R:R:F403	R:R:W491	6.01	No	No	0	5	5
314	R:R:A404	R:R:L452	4.73	No	Yes	0	8	7
315	R:R:D405	R:R:S453	5.89	Yes	No	0	9	8
316	R:R:D405	R:R:S616	4.42	Yes	Yes	0	9	9
317	R:R:D405	R:R:N619	8.08	Yes	Yes	0	9	9
318	R:R:F406	R:R:L410	14.61	No	No	0	4	4
319	R:R:?407	R:R:?409	10.34	Yes	Yes	2	7	9
320	R:R:?407	R:R:L410	8.89	Yes	No	0	7	4
321	R:R:?407	R:R:?411	5.77	Yes	Yes	2	7	7
322	R:R:?407	R:R:A449	5.06	Yes	No	0	7	8
323	R:R:?612	R:R:M408	9.62	Yes	No	0	7	8
324	R:R:M408	R:R:S616	4.6	No	Yes	0	8	9
325	R:R:?409	R:R:?411	9.39	Yes	Yes	2	9	7
326	R:R:?411	R:R:L412	9.42	Yes	No	0	7	8
327	R:R:?411	R:R:I415	18.05	Yes	No	0	7	8
328	R:R:?411	R:R:F445	4.74	Yes	No	0	7	7
329	R:R:?411	R:R:T446	11.47	Yes	No	2	7	8
330	R:R:?411	R:R:F515	5.92	Yes	Yes	2	7	9
331	R:R:V418	R:R:W433	17.16	No	No	0	7	9
332	R:R:?426	R:R:T422	7.17	Yes	No	0	9	9
333	R:R:?423	R:R:?424	7.92	No	No	0	5	7
334	R:R:N428	R:R:Q425	5.28	No	No	0	6	4
335	R:R:?426	R:R:?427	27.5	Yes	Yes	4	9	7
336	R:R:?426	R:R:A430	12.26	Yes	No	4	9	9
337	R:R:?426	R:R:W433	7.75	Yes	No	0	9	9
338	R:R:?426	R:R:Q434	5.18	Yes	No	0	9	9
339	R:R:?426	R:R:S512	4.38	Yes	No	0	9	9
340	R:R:?427	R:R:N428	18.7	Yes	No	0	7	6
341	R:R:?427	R:R:A430	4.6	Yes	No	4	7	9
342	R:R:M509	R:R:T435	7.53	No	No	0	6	6
343	R:R:?436	R:R:?438	6.32	No	Yes	2	9	8
344	R:R:?436	R:R:?439	6.46	No	Yes	2	9	9
345	R:R:?438	R:R:?439	19.39	Yes	Yes	2	8	9
346	R:R:?438	R:R:T441	9	Yes	No	0	8	3
347	R:R:?439	R:R:S440	4.82	Yes	No	0	9	4
348	R:R:?439	R:R:A442	5.06	Yes	No	0	9	8
349	R:R:?439	R:R:?508	4.32	Yes	Yes	2	9	8
350	R:R:?439	R:R:?514	19.05	Yes	Yes	2	9	9
351	R:R:F445	R:R:T441	5.19	No	No	0	7	3
352	R:R:?443	R:R:T446	10.28	No	No	2	9	8
353	R:R:?443	R:R:?508	22.31	No	Yes	2	9	8
354	R:R:?443	R:R:?514	5.17	No	Yes	2	9	9
355	R:R:F515	R:R:T446	5.19	Yes	No	2	9	8
356	R:R:?508	R:R:V447	7.24	Yes	No	0	8	8
357	R:R:?612	R:R:S450	7.3	Yes	No	0	7	8
358	R:R:E451	R:R:I531	5.47	No	No	0	9	6
359	R:R:E451	R:R:N535	6.57	No	No	0	9	9
360	R:R:L452	R:R:W491	9.11	Yes	No	0	7	5
361	R:R:L452	R:R:S494	7.51	Yes	No	0	7	7
362	R:R:?455	R:R:V454	4.35	Yes	No	0	8	7
363	R:R:N535	R:R:V454	4.43	No	No	0	9	7
364	R:R:?455	R:R:T456	4.3	Yes	No	0	8	8
365	R:R:?455	R:R:T458	15.77	Yes	No	0	8	8
366	R:R:?455	R:R:V459	11.59	Yes	No	0	8	4
367	R:R:?455	R:R:?490	8.22	Yes	No	0	8	8
368	R:R:L457	R:R:N619	8.24	No	Yes	17	9	9
369	R:R:I541	R:R:T458	4.56	No	No	0	4	8
370	R:R:M487	R:R:V459	4.56	No	No	0	7	4
371	R:R:I460	R:R:R464	5.01	No	No	0	9	8
372	R:R:I542	R:R:T461	13.68	No	No	0	8	8
373	R:R:?546	R:R:T461	14.34	Yes	No	0	9	8
374	R:R:E463	R:R:R464	8.14	No	No	0	9	8
375	R:R:?623	R:R:R464	7.09	Yes	No	0	9	8
376	R:R:T469	R:R:W465	9.7	No	No	0	5	5
377	R:R:?545	R:R:W465	8.54	Yes	No	3	6	5
378	R:R:I549	R:R:W465	4.7	Yes	No	3	9	5
379	R:R:?470	R:R:H466	10	Yes	No	0	3	5
380	R:R:I468	R:R:I549	5.89	No	Yes	3	7	9
381	R:R:?470	R:R:T469	12.9	Yes	No	0	3	5
382	R:R:H473	R:R:I472	6.63	No	No	0	4	5
383	R:R:H473	R:R:Q476	6.18	No	No	0	4	5
384	R:R:D475	R:R:Q476	5.22	No	No	0	4	5
385	R:R:I484	R:R:L480	4.28	No	No	0	3	3
386	R:R:?489	R:R:L488	4.83	No	No	0	3	1
387	R:R:?489	R:R:?490	13.68	No	No	0	3	8
388	R:R:F493	R:R:I497	6.28	No	Yes	0	5	5
389	R:R:?527	R:R:I497	5.55	Yes	Yes	18	7	5
390	R:R:I497	R:R:I531	5.89	Yes	No	18	5	6
391	R:R:L500	R:R:V505	8.94	No	Yes	0	5	5
392	R:R:?508	R:R:P501	20.76	Yes	No	0	8	9
393	R:R:?527	R:R:P501	6.39	Yes	No	0	7	9
394	R:R:L523	R:R:V505	5.96	No	Yes	0	4	5
395	R:R:?527	R:R:V505	4.35	Yes	Yes	0	7	5
396	R:R:S506	R:R:S524	4.89	No	No	0	8	7
397	R:R:?527	R:R:S506	4.38	Yes	No	0	7	8
398	R:R:D518	R:R:N507	14.81	No	No	0	7	7
399	R:R:?508	R:R:?514	23.07	Yes	Yes	2	8	9
400	R:R:?508	R:R:P516	7.99	Yes	No	2	8	9
401	R:R:?510	R:R:D518	4.86	No	No	0	6	7
402	R:R:I513	R:R:V511	4.61	No	No	0	9	9
403	R:R:?514	R:R:V511	4.79	Yes	No	0	9	9
404	R:R:M517	R:R:V511	6.09	No	No	0	8	9
405	R:R:F515	R:R:I513	8.79	Yes	No	0	9	9
406	R:R:I513	R:R:L608	8.56	No	No	0	9	8
407	R:R:F515	R:R:P516	4.33	Yes	No	2	9	9
408	R:R:?612	R:R:F515	10.66	Yes	Yes	0	7	9
409	R:R:F515	W:W:?801	12.52	Yes	Yes	2	9	0
410	R:R:P516	W:W:?801	6.03	No	Yes	2	9	0
411	R:R:M517	W:W:?801	21.8	No	Yes	0	8	0
412	R:R:D518	R:R:E520	9.09	No	No	0	7	5
413	R:R:Q525	R:R:V519	5.73	No	No	0	6	6
414	R:R:?527	R:R:V526	5.8	Yes	No	0	7	4
415	R:R:?527	R:R:I528	11.11	Yes	No	0	7	6
416	R:R:?527	R:R:T530	7.17	Yes	No	0	7	4
417	R:R:?527	R:R:I531	15.27	Yes	No	18	7	6
418	R:R:I528	W:W:?801	5.24	No	Yes	0	6	0
419	R:R:F594	R:R:L529	8.53	No	No	0	6	6
420	R:R:A589	R:R:L532	4.73	No	No	0	9	9
421	R:R:I590	R:R:L532	7.14	No	No	0	7	9
422	R:R:F540	R:R:V536	6.55	No	No	0	4	7
423	R:R:S586	R:R:V536	4.85	No	No	0	9	7
424	R:R:F539	R:R:F540	4.29	Yes	No	0	8	4
425	R:R:D578	R:R:F539	4.78	No	Yes	0	8	8
426	R:R:F539	R:R:F579	6.43	Yes	No	0	8	8
427	R:R:F539	R:R:M582	7.46	Yes	No	0	8	7
428	R:R:?543	R:R:I542	4.59	Yes	No	0	7	8
429	R:R:?543	R:R:?545	9.52	Yes	Yes	3	7	6
430	R:R:?543	R:R:?546	8.65	Yes	Yes	3	7	9
431	R:R:?543	R:R:I547	7.64	Yes	No	0	7	5
432	R:R:?545	R:R:?546	25.95	Yes	Yes	3	6	9
433	R:R:?545	R:R:?548	7.96	Yes	Yes	3	6	4
434	R:R:?545	R:R:I549	6.11	Yes	Yes	3	6	9
435	R:R:?546	R:R:?548	6.42	Yes	Yes	3	9	4
436	R:R:?546	R:R:I549	6.94	Yes	Yes	3	9	9
437	R:R:?546	R:R:?550	5.24	Yes	Yes	3	9	9
438	R:R:?546	R:R:M571	12.37	Yes	No	3	9	8
439	R:R:?546	R:R:I575	6.94	Yes	No	0	9	9
440	R:R:?546	R:R:?623	6.55	Yes	Yes	0	9	9
441	R:R:F551	R:R:I547	6.28	No	No	0	4	5
442	R:R:?548	R:R:?550	5.62	Yes	Yes	3	4	9
443	R:R:?550	R:R:I549	5.55	Yes	Yes	3	9	9
444	R:R:I549	R:R:M571	4.37	Yes	No	3	9	8
445	R:R:?550	R:R:F551	13.03	Yes	No	0	9	4
446	R:R:?550	R:R:D564	5.28	Yes	No	0	9	8
447	R:R:D564	R:R:R554	8.34	No	No	0	8	5
448	R:R:M559	R:R:T561	4.52	No	No	0	2	4
449	R:R:A560	R:R:D564	4.63	No	No	0	3	8
450	R:R:?566	R:R:?569	4.43	No	Yes	0	5	7
451	R:R:I567	R:R:M571	4.37	No	No	0	7	8
452	R:R:?569	R:R:?570	8.87	Yes	No	19	7	9
453	R:R:?569	R:R:I573	4.26	Yes	No	19	7	5
454	R:R:?570	R:R:I573	7.66	No	No	19	9	5
455	R:R:?570	R:R:L574	5.78	No	No	0	9	9
456	R:R:?623	R:R:L574	9.42	Yes	No	0	9	9
457	R:R:L622	R:R:T577	4.42	No	No	0	9	9
458	R:R:D578	R:R:N615	5.39	No	No	0	8	9
459	R:R:A583	R:R:F579	8.32	No	No	0	8	8
460	R:R:?581	R:R:T580	6.31	Yes	No	0	9	6
461	R:R:?581	R:R:I614	6.11	Yes	No	0	9	8
462	R:R:?581	R:R:N615	7.35	Yes	No	0	9	9
463	R:R:M582	R:R:S586	4.6	No	No	0	7	9
464	R:R:F611	R:R:P584	4.33	No	No	0	8	9
465	R:R:A589	W:W:?801	6.94	No	Yes	0	9	0
466	R:R:L598	R:R:S591	7.51	No	No	0	7	8
467	R:R:A592	W:W:?801	4.63	No	Yes	0	9	0
468	R:R:?595	R:R:P597	4.9	No	No	0	6	5
469	R:R:P597	W:W:?801	6.03	No	Yes	0	5	0
470	R:R:I599	R:R:N603	5.66	No	No	0	8	6
471	R:R:N603	R:R:T600	4.39	No	No	0	6	8
472	R:R:V601	W:W:?801	5.47	No	Yes	0	8	0
473	R:R:S604	W:W:?801	9.92	No	Yes	0	6	0
474	R:R:?605	R:R:L608	5.78	No	No	0	9	8
475	R:R:L610	R:R:V606	4.47	No	No	0	7	7
476	R:R:F611	R:R:L610	4.87	No	No	0	8	7
477	R:R:?612	R:R:P613	19.17	Yes	No	0	7	9
478	R:R:P613	R:R:S616	5.34	No	Yes	0	9	9
479	R:R:N615	R:R:N619	9.54	No	Yes	0	9	9
480	R:R:?617	R:R:S616	6.43	Yes	Yes	0	9	9
481	R:R:?617	R:R:P620	7.03	Yes	No	0	9	9
482	R:R:F621	R:R:I625	5.02	No	No	0	8	7
483	R:R:F626	R:R:I625	5.02	No	No	0	8	7
484	R:R:F630	R:R:I625	11.3	Yes	No	0	8	7
485	R:R:?628	R:R:T627	4.4	No	No	0	7	9
486	R:R:F634	R:R:L638	7.31	No	No	0	5	4
487	R:R:?643	R:R:L638	5.93	No	No	10	2	4
488	R:R:?644	R:R:L638	8.89	No	No	10	4	4
489	R:R:?642	R:R:?643	19.39	No	No	10	4	2
490	R:R:?642	R:R:?644	5.17	No	No	10	4	4
491	R:R:?643	R:R:?644	26.98	No	No	10	2	4
492	L:L:Q29	N:N:R28	5.84	No	Yes	0	0	0
493	L:L:?31	L:L:D30	11.63	Yes	No	0	0	0
494	L:L:?31	L:L:P32	15.83	Yes	No	0	0	0
495	L:L:?31	L:L:?55	12.7	Yes	Yes	1	0	0
496	L:L:?31	N:N:R26	13.01	Yes	Yes	1	0	0
497	L:L:?31	N:N:?57	7.21	Yes	Yes	1	0	0
498	L:L:E33	N:N:R26	22.1	No	Yes	0	0	0
499	L:L:?34	L:L:T35	4.74	Yes	No	0	0	0
500	L:L:?34	L:L:?54	12.93	Yes	No	1	0	0
501	L:L:?34	L:L:?55	6.35	Yes	Yes	1	0	0
502	L:L:?34	L:L:?84	9.52	Yes	Yes	1	0	0
503	L:L:Q37	L:L:T35	4.25	No	No	0	0	0
504	L:L:L36	L:L:L50	12.46	No	No	0	0	0
505	L:L:?52	L:L:L36	4.45	Yes	No	0	0	0
506	L:L:M53	L:L:Q37	9.52	No	No	0	0	0
507	L:L:E38	L:L:S43	5.75	No	No	0	0	0
508	L:L:N39	L:L:P40	4.89	Yes	No	0	0	0
509	L:L:F41	L:L:N39	4.83	No	Yes	0	0	0
510	L:L:N39	L:L:S43	4.47	Yes	No	20	0	0
511	L:L:I49	L:L:N39	4.25	No	Yes	20	0	0
512	L:L:I49	L:L:S43	4.64	No	No	20	0	0
513	L:L:?52	L:L:Q51	7.13	Yes	No	0	0	0
514	L:L:Q51	N:N:M61	5.44	No	No	0	0	0
515	L:L:Q51	N:N:V64	4.3	No	No	0	0	0
516	L:L:?52	L:L:M53	9.08	Yes	No	0	0	0
517	L:L:?106	L:L:?52	9.52	No	Yes	0	0	0
518	L:L:M53	N:N:M61	7.22	No	No	0	0	0
519	L:L:?54	L:L:?55	18.1	No	Yes	1	0	0
520	L:L:?55	L:L:?56	28.57	Yes	No	1	0	0
521	L:L:?55	N:N:?57	8.65	Yes	Yes	1	0	0
522	L:L:?55	N:N:?58	9.52	Yes	Yes	1	0	0
523	L:L:?108	L:L:?56	9.52	Yes	No	1	0	0
524	L:L:?56	N:N:?57	34.6	No	Yes	1	0	0
525	L:L:F57	L:L:R59	8.55	No	No	1	0	0
526	L:L:F57	N:N:?56	5.31	No	No	1	0	0
527	L:L:F57	N:N:?57	7.11	No	Yes	1	0	0
528	L:L:S58	N:N:V76	6.46	No	Yes	1	0	0
529	L:L:S58	N:N:?77	6.43	No	Yes	1	0	0
530	L:L:?61	L:L:R59	4.73	Yes	No	1	0	0
531	L:L:R59	N:N:L128	4.86	No	No	1	0	0
532	L:L:A60	N:N:?79	4.6	No	Yes	0	0	0
533	L:L:?61	L:L:P62	14.37	Yes	No	0	0	0
534	L:L:?61	L:L:V77	7.24	Yes	No	0	0	0
535	L:L:?61	L:L:T78	12.9	Yes	No	0	0	0
536	L:L:?61	N:N:L128	8.08	Yes	No	1	0	0
537	L:L:P62	N:N:L36	4.93	No	No	0	0	0
538	L:L:?68	L:L:T63	5.28	No	No	0	0	0
539	L:L:?69	L:L:L65	4.95	No	No	0	0	0
540	L:L:L65	N:N:E39	7.95	No	No	0	0	0
541	L:L:?69	L:L:R66	7.97	No	No	0	0	0
542	L:L:?68	L:L:?69	8.87	No	No	0	0	0
543	L:L:M71	N:N:D119	8.32	No	Yes	0	0	0
544	L:L:N76	L:L:V77	7.39	No	No	0	0	0
545	L:L:V77	N:N:?79	7.24	No	Yes	0	0	0
546	L:L:T78	N:N:D119	5.78	No	Yes	0	0	0
547	L:L:S79	N:N:?120	9.65	No	Yes	0	0	0
548	L:L:E80	N:N:?122	11.56	No	Yes	0	0	0
549	L:L:E80	N:N:?124	5.53	No	Yes	0	0	0
550	L:L:S81	N:N:V76	8.08	No	Yes	0	0	0
551	L:L:?83	L:L:T82	4.74	Yes	No	1	0	0
552	L:L:?108	L:L:T82	7.89	Yes	No	1	0	0
553	L:L:?83	L:L:?84	22.22	Yes	Yes	1	0	0
554	L:L:?108	L:L:?83	9.52	Yes	Yes	1	0	0
555	L:L:?111	L:L:?83	15.87	Yes	Yes	1	0	0
556	L:L:?83	N:N:T60	4.74	Yes	No	0	0	0
557	L:L:?83	N:N:Q74	9.98	Yes	Yes	1	0	0
558	L:L:?84	L:L:V85	4.79	Yes	No	0	0	0
559	L:L:?108	L:L:?84	12.7	Yes	Yes	1	0	0
560	L:L:A86	L:L:H103	8.78	No	No	0	0	0
561	L:L:?87	L:L:H107	4.6	No	No	0	0	0
562	L:L:S88	L:L:T104	4.8	No	No	0	0	0
563	L:L:?89	L:L:N90	5.34	Yes	No	0	0	0
564	L:L:?89	L:L:E101	19.33	Yes	No	0	0	0
565	L:L:?89	L:L:T104	4.3	Yes	No	0	0	0
566	L:L:N102	L:L:N90	6.81	No	No	0	0	0
567	L:L:?99	L:L:R91	15.22	Yes	No	0	0	0
568	L:L:?96	L:L:?97	12.63	No	No	0	0	0
569	L:L:?97	L:L:F98	5.31	No	No	0	0	0
570	L:L:?99	L:L:E101	4.74	Yes	No	0	0	0
571	L:L:?108	L:L:H107	15.14	Yes	No	0	0	0
572	L:L:S109	L:L:T110	4.8	No	Yes	0	0	0
573	L:L:?111	L:L:T110	7.89	Yes	Yes	1	0	0
574	L:L:?112	L:L:T110	7.17	Yes	Yes	1	0	0
575	L:L:T110	N:N:?122	5.14	Yes	Yes	0	0	0
576	L:L:?111	L:L:?112	30.27	Yes	Yes	1	0	0
577	L:L:?111	L:L:H114	22.03	Yes	Yes	1	0	0
578	L:L:?111	N:N:Q74	12.83	Yes	Yes	1	0	0
579	L:L:?112	L:L:?113	24.88	Yes	Yes	1	0	0
580	L:L:?112	L:L:H114	12.5	Yes	Yes	1	0	0
581	L:L:?112	N:N:Q74	5.18	Yes	Yes	1	0	0
582	L:L:?113	L:L:H114	7.5	Yes	Yes	1	0	0
583	L:L:?113	N:N:A71	10.73	Yes	No	0	0	0
584	L:L:?113	N:N:Q74	19.42	Yes	Yes	1	0	0
585	L:L:?115	L:L:H114	12.27	Yes	Yes	1	0	0
586	L:L:H114	N:N:?113	5.51	Yes	Yes	1	0	0
587	L:L:H114	N:N:?120	12.39	Yes	Yes	1	0	0
588	L:L:?115	L:L:S116	5.37	Yes	No	0	0	0
589	L:L:?115	N:N:?113	7.96	Yes	Yes	1	0	0
590	L:L:S116	N:N:L112	4.5	No	No	0	0	0
591	N:N:?22	N:N:E23	5.53	No	No	0	0	0
592	N:N:L25	N:N:R26	4.86	No	Yes	0	0	0
593	N:N:?57	N:N:R26	7.09	Yes	Yes	1	0	0
594	N:N:P27	N:N:R30	11.53	No	Yes	0	0	0
595	N:N:?29	N:N:R28	6.5	Yes	Yes	1	0	0
596	N:N:?57	N:N:R28	5.91	Yes	Yes	1	0	0
597	N:N:?58	N:N:R28	5.2	Yes	Yes	1	0	0
598	N:N:P59	N:N:R28	5.76	No	Yes	1	0	0
599	N:N:?29	N:N:R30	5.2	Yes	Yes	0	0	0
600	N:N:?29	N:N:?56	7.76	Yes	No	1	0	0
601	N:N:?29	N:N:?57	10.09	Yes	Yes	1	0	0
602	N:N:?29	N:N:?77	15.87	Yes	Yes	1	0	0
603	N:N:?108	N:N:?29	7.94	Yes	Yes	1	0	0
604	N:N:I32	N:N:R30	12.53	No	Yes	0	0	0
605	N:N:A34	N:N:I53	4.87	No	No	0	0	0
606	N:N:T35	N:N:T48	4.71	No	No	0	0	0
607	N:N:A37	N:N:E39	4.53	No	No	0	0	0
608	N:N:?130	N:N:A37	6.75	Yes	No	0	0	0
609	N:N:V38	N:N:V49	6.41	No	No	5	0	0
610	N:N:?102	N:N:V38	4.35	Yes	No	5	0	0
611	N:N:?46	N:N:E39	8.51	Yes	No	0	0	0
612	N:N:?40	N:N:?43	7.07	No	Yes	0	0	0
613	N:N:?42	N:N:?43	19.39	Yes	Yes	8	0	0
614	N:N:?42	N:N:P44	4.3	Yes	No	8	0	0
615	N:N:?42	N:N:P93	7.16	Yes	No	0	0	0
616	N:N:?43	N:N:P44	17.58	Yes	No	8	0	0
617	N:N:?43	N:N:L89	4.45	Yes	No	8	0	0
618	N:N:?43	N:N:?92	9.52	Yes	Yes	8	0	0
619	N:N:?46	N:N:V45	9.57	Yes	No	0	0	0
620	N:N:?46	N:N:I47	10.7	Yes	No	0	0	0
621	N:N:?130	N:N:?46	9.52	Yes	Yes	0	0	0
622	N:N:I47	N:N:L89	7.14	No	No	0	0	0
623	N:N:?102	N:N:V49	5.8	Yes	No	5	0	0
624	N:N:?102	N:N:T51	8.6	Yes	No	5	0	0
625	N:N:T51	N:N:V104	4.76	No	Yes	5	0	0
626	N:N:T52	N:N:V104	4.76	No	Yes	0	0	0
627	N:N:?54	N:N:I53	9.17	Yes	No	0	0	0
628	N:N:?54	N:N:A55	5.06	Yes	No	0	0	0
629	N:N:?54	N:N:?77	6.35	Yes	Yes	1	0	0
630	N:N:?54	N:N:?79	4.32	Yes	Yes	1	0	0
631	N:N:?108	N:N:?54	9.52	Yes	Yes	1	0	0
632	N:N:?56	N:N:?57	23.48	No	Yes	1	0	0
633	N:N:?57	N:N:?58	24.51	Yes	Yes	1	0	0
634	N:N:?58	N:N:P59	19.34	Yes	No	1	0	0
635	N:N:?58	N:N:T60	4.74	Yes	No	0	0	0
636	N:N:?110	N:N:?58	9.52	Yes	Yes	0	0	0
637	N:N:L69	N:N:R63	9.72	No	No	0	0	0
638	N:N:L72	N:N:R63	17.01	No	No	0	0	0
639	N:N:L69	N:N:P70	4.93	No	No	0	0	0
640	N:N:?110	N:N:V75	19.14	Yes	No	0	0	0
641	N:N:?77	N:N:V76	12.76	Yes	Yes	1	0	0
642	N:N:N78	N:N:V76	4.43	Yes	Yes	1	0	0
643	N:N:?113	N:N:V76	4.79	Yes	Yes	1	0	0
644	N:N:?77	N:N:N78	11.76	Yes	Yes	1	0	0
645	N:N:?110	N:N:?77	11.11	Yes	Yes	0	0	0
646	N:N:?79	N:N:N78	6.68	Yes	Yes	1	0	0
647	N:N:?113	N:N:N78	4.41	Yes	Yes	1	0	0
648	N:N:N78	N:N:T118	4.39	Yes	No	1	0	0
649	N:N:?79	N:N:V82	5.8	Yes	No	0	0	0
650	N:N:?79	N:N:A105	4.6	Yes	No	0	0	0
651	N:N:?108	N:N:?79	14.42	Yes	Yes	1	0	0
652	N:N:R80	N:N:S107	11.86	No	No	0	0	0
653	N:N:?108	N:N:R80	11.71	Yes	No	1	0	0
654	N:N:Q109	N:N:R80	4.67	Yes	No	1	0	0
655	N:N:E85	N:N:R83	4.65	No	No	5	0	0
656	N:N:R83	N:N:V104	5.23	No	Yes	5	0	0
657	N:N:?102	N:N:F84	7.11	Yes	No	0	0	0
658	N:N:?102	N:N:E85	21.91	Yes	No	5	0	0
659	N:N:E85	N:N:V104	7.13	No	Yes	5	0	0
660	N:N:P98	N:N:R88	7.21	No	No	0	0	0
661	N:N:?92	N:N:L89	4.45	Yes	No	8	0	0
662	N:N:?91	N:N:P90	4.3	No	No	0	0	0
663	N:N:?91	N:N:?92	20.68	No	Yes	0	0	0
664	N:N:?92	N:N:P93	17.58	Yes	No	0	0	0
665	N:N:?95	N:N:V96	5.2	No	No	0	0	0
666	N:N:N97	N:N:V96	4.43	No	No	0	0	0
667	N:N:?102	N:N:S101	4.38	Yes	No	0	0	0
668	N:N:?102	N:N:V104	4.35	Yes	Yes	5	0	0
669	N:N:?108	N:N:Q109	5.7	Yes	Yes	1	0	0
670	N:N:?110	N:N:Q109	17.1	Yes	Yes	0	0	0
671	N:N:A111	N:N:Q109	4.55	No	Yes	0	0	0
672	N:N:?113	N:N:T118	6.31	Yes	No	1	0	0
673	N:N:?113	N:N:?120	11.11	Yes	Yes	1	0	0
674	N:N:S116	N:N:T117	4.8	No	No	0	0	0
675	N:N:?120	N:N:D119	5.81	Yes	Yes	0	0	0
676	N:N:?120	N:N:?121	15.51	Yes	No	0	0	0
677	N:N:?121	N:N:?122	12.63	No	Yes	0	0	0
678	N:N:?122	N:N:P123	11.46	Yes	No	0	0	0
679	N:N:?124	N:N:D125	8.91	Yes	No	0	0	0
680	N:N:?124	N:N:H126	10.74	Yes	No	0	0	0
681	N:N:H126	N:N:P127	9.15	No	No	0	0	0
682	N:N:?130	N:N:T129	9.47	Yes	No	21	0	0
683	N:N:D131	N:N:T129	4.34	No	No	21	0	0
684	N:N:?130	N:N:D131	18.89	Yes	No	21	0	0
685	R:R:A93	R:R:F94	4.16	No	No	0	8	9
686	R:R:A498	R:R:F444	4.16	No	No	0	9	8
687	R:R:L54	R:R:L56	4.15	No	No	0	7	6
688	R:R:L125	R:R:L128	4.15	Yes	No	0	9	8
689	R:R:L128	R:R:L153	4.15	No	No	0	8	9
690	R:R:L202	R:R:L227	4.15	Yes	No	0	7	8
691	R:R:L256	R:R:L259	4.15	No	Yes	0	8	6
692	R:R:L259	R:R:L273	4.15	Yes	No	0	6	7
693	R:R:?126	R:R:L125	4.13	Yes	Yes	0	5	9
694	R:R:?212	R:R:L210	4.13	No	No	0	2	8
695	R:R:?508	R:R:M509	4.12	Yes	No	0	8	6
696	R:R:H429	R:R:T422	4.11	No	No	0	6	9
697	L:L:?75	L:L:N76	4.1	No	No	0	0	0
698	R:R:?389	R:R:L636	4.04	Yes	No	0	3	3
699	R:R:?411	R:R:L414	4.04	Yes	No	0	7	4
700	R:R:?508	R:R:L502	4.04	Yes	No	0	8	7
701	R:R:N167	R:R:Q170	3.96	No	No	0	7	3
702	R:R:N351	R:R:Q434	3.96	No	No	0	8	9
703	R:R:?436	R:R:S437	3.93	No	No	2	9	2
704	R:R:?438	R:R:S437	3.93	Yes	No	2	8	2
705	L:L:F42	L:L:V94	3.93	No	No	0	0	0
706	R:R:?504	R:R:V505	3.9	No	Yes	0	6	5
707	N:N:?67	N:N:V68	3.9	No	No	0	0	0
708	N:N:?92	N:N:R88	3.9	Yes	No	0	0	0
709	N:N:?113	N:N:R114	3.9	Yes	No	0	0	0
710	L:L:R91	L:L:T93	3.88	No	No	0	0	0
711	L:L:?89	R:R:E148	3.87	Yes	No	0	0	5
712	R:R:H482	R:R:L478	3.86	No	No	0	5	4
713	R:R:A68	R:R:P65	3.74	No	No	0	8	6
714	R:R:?376	R:R:M375	3.7	No	No	0	7	2
715	L:L:?96	L:L:M95	3.7	No	No	0	0	0
716	R:R:F361	R:R:L365	3.65	No	No	0	5	6
717	R:R:F448	R:R:L452	3.65	No	Yes	0	8	7
718	R:R:F493	R:R:L534	3.65	No	No	0	5	5
719	R:R:F588	R:R:L607	3.65	No	No	0	8	8
720	L:L:F42	N:N:L65	3.65	No	No	0	0	0
721	N:N:L106	N:N:R83	3.64	No	No	0	0	0
722	R:R:?489	R:R:L492	3.62	No	No	0	3	1
723	R:R:?166	R:R:N167	3.59	No	No	0	4	7
724	R:R:D355	R:R:R363	3.57	No	No	0	7	9
725	L:L:P64	L:L:S67	3.56	No	No	0	0	0
726	R:R:?595	R:R:V596	3.55	No	No	0	6	5
727	L:L:?99	L:L:V100	3.55	Yes	No	0	0	0
728	N:N:R63	R:R:?331	3.54	No	Yes	0	0	1
729	R:R:?225	R:R:T226	3.52	No	No	0	3	4
730	R:R:I366	R:R:W367	3.52	No	No	0	9	9
731	R:R:?566	R:R:T565	3.52	No	No	0	5	6
732	R:R:F630	R:R:Q631	3.51	Yes	No	0	8	6
733	R:R:F635	R:R:Q631	3.51	No	No	0	4	6
734	R:R:P341	R:R:T340	3.5	No	No	0	6	4
735	R:R:E263	R:R:R262	3.49	No	No	0	4	5
736	R:R:?358	R:R:E354	3.47	No	Yes	0	8	7
737	N:N:?42	N:N:E41	3.47	Yes	No	0	0	0
738	R:R:?563	R:R:I567	3.41	No	No	0	5	7
739	R:R:I64	R:R:P65	3.39	No	No	0	7	6
740	R:R:A498	R:R:V447	3.39	No	No	0	9	8
741	R:R:?343	R:R:A344	3.37	No	No	0	9	6
742	R:R:?543	R:R:A544	3.37	Yes	No	3	7	3
743	R:R:?545	R:R:A544	3.37	Yes	No	3	6	3
744	R:R:?617	R:R:A618	3.37	Yes	No	0	9	7
745	N:N:A105	N:N:T52	3.36	No	No	0	0	0
746	R:R:V519	W:W:?801	3.28	No	Yes	0	6	0
747	R:R:S146	R:R:V144	3.23	No	No	0	7	7
748	N:N:S86	N:N:V99	3.23	No	No	0	0	0
749	L:L:F41	L:L:F42	3.22	No	No	0	0	0
750	L:L:V100	L:L:V92	3.21	No	No	0	0	0
751	R:R:S176	R:R:T200	3.2	No	No	0	5	4
752	N:N:?95	N:N:R94	3.18	No	No	0	0	0
753	R:R:A593	R:R:L529	3.15	No	No	0	7	6
754	R:R:T162	R:R:T163	3.14	No	No	0	3	3
755	R:R:A91	R:R:N92	3.13	No	Yes	0	5	6
756	R:R:A560	R:R:N555	3.13	No	No	0	3	7
757	R:R:I486	R:R:V459	3.07	No	No	0	5	4
758	N:N:I47	N:N:V38	3.07	No	No	0	0	0
759	R:R:?470	R:R:A471	3.06	Yes	No	0	3	6
760	R:R:?581	R:R:I585	3.06	Yes	No	0	9	9
761	N:N:?102	N:N:A103	3.06	Yes	No	0	0	0
762	R:R:I105	R:R:T108	3.04	No	No	0	8	8
763	R:R:L153	R:R:V141	2.98	No	No	0	9	5
764	R:R:L368	R:R:V364	2.98	No	No	0	4	6
765	R:R:L397	R:R:V393	2.98	No	No	0	7	8
766	R:R:?545	R:R:L462	2.96	Yes	No	0	6	5
767	R:R:?339	R:R:P286	2.94	No	No	0	3	4
768	L:L:S67	R:R:?58	2.92	No	Yes	0	0	5
769	R:R:?240	R:R:S239	2.92	Yes	No	0	2	4
770	N:N:N50	N:N:T35	2.92	No	No	0	0	0
771	R:R:?640	R:R:?642	2.88	No	No	0	4	4
772	N:N:P31	N:N:R30	2.88	No	Yes	0	0	0
773	R:R:?623	R:R:T627	2.87	Yes	No	0	9	9
774	L:L:Q44	L:L:V94	2.87	No	No	0	0	0
775	L:L:?46	L:L:P48	2.86	No	No	0	0	0
776	R:R:I497	R:R:L496	2.85	Yes	No	0	5	3
777	R:R:I585	R:R:L607	2.85	No	No	0	9	8
778	R:R:Q190	R:R:T163	2.83	No	No	0	2	3
779	R:R:E187	R:R:T162	2.82	No	No	0	2	3
780	R:R:E463	R:R:T467	2.82	No	No	0	9	8
781	R:R:M559	R:R:N562	2.8	No	No	0	2	4
782	R:R:L574	R:R:L622	2.77	No	No	0	9	9
783	R:R:?117	R:R:A118	2.75	Yes	No	0	3	7
784	R:R:?216	R:R:A217	2.75	Yes	No	0	3	7
785	R:R:?220	R:R:A221	2.75	No	No	0	5	8
786	L:L:?46	L:L:A47	2.75	No	No	0	0	0
787	L:L:?52	L:L:H103	2.75	Yes	No	0	0	0
788	L:L:H103	N:N:T62	2.74	No	No	0	0	0
789	N:N:V68	R:R:?225	2.67	No	No	0	0	3
790	N:N:?40	N:N:V96	2.67	No	No	0	0	0
791	R:R:R124	R:R:S101	2.64	No	No	0	6	5
792	R:R:F444	R:R:S495	2.64	No	No	0	8	3
793	R:R:F448	R:R:S495	2.64	No	No	0	8	3
794	R:R:?504	R:R:V503	2.6	No	No	0	6	4
795	R:R:F382	R:R:T386	2.59	No	No	0	1	5
796	N:N:R114	N:N:T117	2.59	No	No	0	0	0
797	R:R:?223	R:R:T222	2.57	No	No	0	7	3
798	R:R:F594	R:R:I590	2.51	No	No	0	6	7
799	R:R:F587	R:R:L598	2.44	No	No	0	7	7
800	R:R:F588	R:R:L598	2.44	No	No	0	8	7
801	R:R:L98	R:R:R124	2.43	No	No	0	6	6
802	L:L:F41	R:R:?331	2.37	No	Yes	0	0	1
803	R:R:A349	W:W:?801	2.31	No	Yes	0	8	0
804	R:R:?640	R:R:F641	2.18	No	No	0	4	2
805	R:R:?477	R:R:R479	2.17	No	No	0	5	5
806	R:R:?71	R:R:R70	2.12	No	No	0	5	2
807	N:N:?22	N:N:P24	1.96	No	No	0	0	0
808	R:R:P276	R:R:P345	1.95	No	No	0	7	9
809	R:R:?548	R:R:A552	1.88	Yes	No	0	4	5
810	R:R:?569	R:R:A568	1.88	Yes	No	0	7	8
811	R:R:?569	R:R:A572	1.88	Yes	No	0	7	9
812	R:R:?640	R:R:S639	1.79	No	No	0	4	5
813	N:N:?40	N:N:V100	1.78	No	No	0	0	0
814	N:N:P98	N:N:V99	1.77	No	No	0	0	0
815	R:R:A57	R:R:S55	1.71	No	No	0	4	4
816	R:R:A250	R:R:S253	1.71	No	No	0	8	7
817	L:L:A105	L:L:S88	1.71	No	No	0	0	0
818	R:R:?77	R:R:I76	1.7	No	No	0	5	3
819	R:R:A193	R:R:V189	1.7	No	No	0	8	7
820	R:R:A538	R:R:V454	1.7	No	No	0	9	7
821	N:N:A37	N:N:T48	1.68	No	No	0	0	0
822	R:R:?477	R:R:L478	1.65	No	No	0	5	4
823	R:R:L59	R:R:P60	1.64	Yes	No	0	7	5
824	R:R:L122	R:R:P123	1.64	No	No	0	8	4
825	N:N:L72	N:N:P73	1.64	No	No	0	0	0
826	N:N:L112	N:N:P73	1.64	No	No	0	0	0
827	R:R:S417	R:R:S420	1.63	No	No	0	4	5
828	R:R:N555	R:R:P556	1.63	No	No	0	7	6
829	R:R:S231	R:R:V208	1.62	No	No	0	6	1
830	R:R:S417	R:R:V418	1.62	No	No	0	4	7
831	R:R:S261	R:R:T264	1.6	No	No	0	4	4
832	R:R:S524	R:R:T521	1.6	No	No	0	7	5
833	L:L:P45	L:L:Q44	1.58	No	No	0	0	0
834	R:R:T521	R:R:T522	1.57	No	No	0	5	4
835	R:R:A349	R:R:D348	1.54	No	No	0	8	9
836	R:R:I468	R:R:V553	1.54	No	No	3	7	7
837	R:R:I533	R:R:V537	1.54	No	No	0	6	4
838	R:R:I541	R:R:V537	1.54	No	No	0	4	4
839	R:R:I549	R:R:V553	1.54	Yes	No	3	9	7
840	N:N:I87	N:N:V100	1.54	No	No	0	0	0
841	L:L:A47	L:L:Q44	1.52	No	No	0	0	0
842	L:L:M95	L:L:V94	1.52	No	No	0	0	0
843	L:L:V73	R:R:L159	1.49	No	No	0	0	3
844	R:R:L365	R:R:V364	1.49	No	No	0	6	6
845	R:R:?399	R:R:L385	1.48	Yes	No	0	8	6
846	N:N:D81	N:N:S107	1.47	No	No	0	0	0
847	R:R:I486	R:R:L485	1.43	No	No	0	5	2
848	R:R:I76	R:R:N99	1.42	No	No	0	3	5
849	R:R:I120	R:R:N121	1.42	Yes	No	0	5	7
850	R:R:Q421	R:R:T422	1.42	No	No	0	3	9
851	N:N:I32	N:N:N33	1.42	No	No	0	0	0
852	R:R:E188	R:R:T163	1.41	No	No	0	5	3
853	R:R:E270	R:R:T272	1.41	No	No	0	6	6
854	R:R:L636	R:R:L637	1.38	No	No	0	3	7
855	R:R:?409	R:R:A373	1.37	Yes	No	0	9	9
856	R:R:L558	R:R:N555	1.37	No	No	0	4	7
857	R:R:N121	R:R:N96	1.36	No	No	0	7	5
858	R:R:E463	R:R:L478	1.33	No	No	0	9	4
859	R:R:E175	R:R:N174	1.31	No	No	0	5	4
860	R:R:F634	R:R:V383	1.31	No	No	0	5	7
861	R:R:?336	R:R:F335	1.3	No	No	0	6	1
862	R:R:R53	R:R:T52	1.29	No	No	0	2	3
863	R:R:?470	R:R:H473	1.25	Yes	No	0	3	4
864	N:N:?22	N:N:P27	0.98	No	No	0	0	0
865	R:R:?62	R:R:S85	0.9	No	No	0	4	5
866	R:R:?477	R:R:L474	0.83	No	No	0	5	3
867	R:R:?563	R:R:N562	0.82	No	No	0	5	4
868	L:L:?75	L:L:Q74	0.79	No	No	0	0	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:?58	7.656	5	0	5
2	R:R:L59	4.9325	4	0	7
3	R:R:Q82	8.37	4	0	6
4	R:R:N92	4.944	5	6	6
5	R:R:E102	8.46	5	1	7
6	R:R:L111	7.7475	4	9	7
7	R:R:?113	7.92	5	9	1
8	R:R:?117	4.31	5	6	3
9	R:R:I120	4.782	5	6	5
10	R:R:L125	4.812	5	0	9
11	R:R:?126	7.412	5	0	5
12	R:R:?127	9.34	5	1	6
13	R:R:?131	13.545	4	1	7
14	R:R:N132	9.19	4	1	8
15	R:R:T133	7.1775	4	0	8
16	R:R:I135	6.1375	4	9	7
17	R:R:F138	8.65	4	0	5
18	R:R:E154	8.4925	4	1	7
19	R:R:?156	13.5533	6	1	7
20	R:R:D157	9.8375	4	1	6
21	R:R:N158	9.355	4	1	9
22	R:R:V177	5.5375	4	11	3
23	R:R:?182	12.2883	6	1	6
24	R:R:?183	7.835	4	1	7
25	R:R:N184	9.06667	6	1	9
26	R:R:F186	8.49333	6	0	8
27	R:R:L202	6.78	4	0	7
28	R:R:?216	5.52	4	12	3
29	R:R:?240	12.8075	4	0	2
30	R:R:L259	5.5625	4	0	6
31	R:R:?275	17.274	5	14	8
32	R:R:?280	13.0925	4	4	9
33	R:R:F282	5.67	4	15	8
34	R:R:R283	6.5875	4	4	3
35	R:R:?331	6.156	5	0	1
36	R:R:E354	6.388	5	0	7
37	R:R:?359	11.958	5	16	6
38	R:R:L362	7.84	4	16	8
39	R:R:?389	9.238	5	0	3
40	R:R:?399	5.745	6	7	8
41	R:R:N400	9.1275	4	7	7
42	R:R:S402	7.3075	4	7	8
43	R:R:D405	6.9525	4	0	9
44	R:R:?407	7.056	5	2	7
45	R:R:?409	6.52	4	2	9
46	R:R:?411	8.6	8	2	7
47	R:R:?426	10.7067	6	4	9
48	R:R:?427	11.875	6	4	7
49	R:R:?438	9.66	4	2	8
50	R:R:?439	9.85	6	2	9
51	R:R:L452	6.25	4	0	7
52	R:R:?455	8.846	5	0	8
53	R:R:?470	6.8025	4	0	3
54	R:R:I497	5.1425	4	18	5
55	R:R:V505	5.7875	4	0	5
56	R:R:?508	11.7312	8	2	8
57	R:R:?514	13.02	4	2	9
58	R:R:F515	7.90167	6	2	9
59	R:R:?527	7.5025	8	18	7
60	R:R:F539	5.74	4	0	8
61	R:R:?543	6.754	5	3	7
62	R:R:?545	9.20143	7	3	6
63	R:R:?546	10.3778	9	3	9
64	R:R:?548	5.47	4	3	4
65	R:R:I549	5.01429	7	3	9
66	R:R:?550	6.944	5	3	9
67	R:R:?569	4.264	5	19	7
68	R:R:?581	5.7075	4	0	9
69	R:R:?612	11.6875	4	0	7
70	R:R:S616	5.1975	4	0	9
71	R:R:?617	5.32	4	0	9
72	R:R:N619	9.555	4	17	9
73	R:R:?623	6.836	5	0	9
74	R:R:F630	7.87	4	0	8
75	L:L:?31	12.076	5	1	0
76	L:L:?34	8.385	4	1	0
77	L:L:N39	4.61	4	20	0
78	L:L:?52	6.586	5	0	0
79	L:L:?55	13.9817	6	1	0
80	L:L:?61	9.464	5	1	0
81	L:L:?83	11.1783	6	1	0
82	L:L:?84	12.3075	4	1	0
83	L:L:?89	8.21	4	0	0
84	L:L:?99	6.9975	4	0	0
85	L:L:?108	10.954	5	1	0
86	L:L:T110	6.412	5	1	0
87	L:L:?111	17.778	5	1	0
88	L:L:?112	13.4057	7	1	0
89	L:L:?113	13.366	5	1	0
90	L:L:H114	12.0333	6	1	0
91	L:L:?115	7.98	4	1	0
92	N:N:R26	11.765	4	1	0
93	N:N:R28	5.842	5	1	0
94	N:N:?29	8.89333	6	1	0
95	N:N:R30	8.035	4	0	0
96	N:N:?42	8.58	4	8	0
97	N:N:?43	11.602	5	8	0
98	N:N:?46	9.575	4	0	0
99	N:N:?54	6.884	5	1	0
100	N:N:?57	14.2944	9	1	0
101	N:N:?58	12.1383	6	1	0
102	N:N:Q74	11.8525	4	1	0
103	N:N:V76	7.304	5	1	0
104	N:N:?77	10.7133	6	1	0
105	N:N:N78	6.334	5	1	0
106	N:N:?79	6.80857	7	1	0
107	N:N:?92	11.226	5	8	0
108	N:N:?102	7.445	8	5	0
109	N:N:V104	5.246	5	5	0
110	N:N:?108	9.858	5	1	0
111	N:N:Q109	8.005	4	1	0
112	N:N:?110	14.2175	4	0	0
113	N:N:?113	6.28429	7	1	0
114	N:N:D119	6.61	4	0	0
115	N:N:?120	10.894	5	1	0
116	N:N:?122	10.1975	4	0	0
117	N:N:?124	7.7	4	0	0
118	N:N:?130	11.1575	4	21	0
119	W:W:?801	7.53583	12	2	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I135	R:R:T133	12.6617	7.6	Yes	Yes	0	7	8
2	R:R:?156	R:R:E154	27.6467	4.26	Yes	Yes	1	7	7
3	R:R:?127	R:R:E154	29.3686	9.02	Yes	Yes	1	6	7
4	R:R:?126	R:R:?127	31.1495	14.46	Yes	Yes	0	5	6
5	R:R:?126	R:R:F151	96.5637	6.54	Yes	No	0	5	5
6	R:R:F151	R:R:V177	96.5897	5.24	No	Yes	11	5	3
7	L:L:?112	R:R:?126	61.9007	4.82	Yes	Yes	0	0	5
8	L:L:?112	L:L:H114	31.8548	12.5	Yes	Yes	1	0	0
9	L:L:?115	R:R:E154	10.6257	6.32	Yes	Yes	1	0	7
10	R:R:F169	R:R:L179	50.0631	4.87	No	No	0	6	8
11	R:R:L179	R:R:V177	99.9637	4.47	No	Yes	0	8	3
12	R:R:F169	R:R:F194	50.0751	5.36	No	No	0	6	9
13	R:R:L179	R:R:L199	49.9883	6.92	No	No	0	8	8
14	R:R:F194	R:R:L199	49.9944	8.53	No	No	0	9	8
15	R:R:F194	R:R:L202	100	9.74	No	Yes	0	9	7
16	R:R:L202	R:R:P224	99.3667	4.93	Yes	No	0	7	8
17	R:R:F218	R:R:P224	98.8605	11.56	No	No	0	8	8
18	R:R:?240	R:R:F218	98.7137	4.74	Yes	No	0	2	8
19	R:R:P260	R:R:T264	97.3491	5.25	No	No	0	6	4
20	R:R:E243	R:R:T264	97.736	4.23	No	No	0	3	4
21	R:R:?241	R:R:E243	97.8127	5.78	No	No	0	7	3
22	R:R:?240	R:R:?241	97.9653	23.48	Yes	No	0	2	7
23	R:R:F265	R:R:P260	95.5748	8.67	No	No	0	7	6
24	R:R:F265	R:R:F282	95.1773	4.29	No	Yes	15	7	8
25	L:L:?115	L:L:S116	13.777	5.37	Yes	No	0	0	0
26	L:L:S116	N:N:L112	13.3743	4.5	No	No	0	0	0
27	N:N:L112	N:N:P73	12.973	1.64	No	No	0	0	0
28	N:N:L72	N:N:P73	12.5717	1.64	No	No	0	0	0
29	N:N:L72	N:N:R63	12.1707	17.01	No	No	0	0	0
30	N:N:R63	R:R:?331	11.5108	3.54	No	Yes	0	0	1
31	R:R:?279	R:R:?280	94.5577	26.98	No	Yes	0	9	9
32	R:R:?279	R:R:F282	94.8153	6.52	No	Yes	0	9	8
33	R:R:?280	R:R:?353	91.8426	15.87	Yes	No	4	9	9
34	R:R:V601	W:W:?801	50.2871	5.47	No	Yes	0	8	0
35	R:R:P352	R:R:V601	50.4139	7.07	No	No	0	9	8
36	R:R:E354	R:R:P352	50.5408	11	Yes	No	0	7	9
37	R:R:?353	R:R:E354	91.9559	4.26	No	Yes	0	9	7
38	R:R:?605	R:R:E354	39.7116	4.74	No	Yes	0	9	7
39	R:R:F515	W:W:?801	38.617	12.52	Yes	Yes	2	9	0
40	R:R:?411	R:R:F515	48.63	5.92	Yes	Yes	2	7	9
41	R:R:?605	R:R:L608	39.5821	5.78	No	No	0	9	8
42	R:R:I513	R:R:L608	39.4588	8.56	No	No	0	9	8
43	R:R:F515	R:R:I513	37.724	8.79	Yes	No	0	9	9
44	R:R:?612	R:R:F515	27.3604	10.66	Yes	Yes	0	7	9
45	R:R:?612	R:R:P613	13.545	19.17	Yes	No	0	7	9
46	R:R:?612	R:R:M408	13.2033	9.62	Yes	No	0	7	8
47	R:R:M408	R:R:S616	12.8852	4.6	No	Yes	0	8	9
48	R:R:D405	R:R:S616	22.4315	4.42	Yes	Yes	0	9	9
49	R:R:P613	R:R:S616	12.9056	5.34	No	Yes	0	9	9
50	R:R:?399	R:R:M398	27.228	4.54	Yes	No	0	8	7
51	R:R:?399	R:R:N400	34.7872	10.29	Yes	Yes	7	8	7
52	R:R:N400	R:R:W491	41.2245	4.52	Yes	No	0	7	5
53	R:R:F403	R:R:W491	42.739	6.01	No	No	0	5	5
54	R:R:?407	R:R:F403	43.0589	5.22	Yes	No	0	7	5
55	R:R:?407	R:R:?411	44.3193	5.77	Yes	Yes	2	7	7
56	R:R:?623	R:R:M398	26.5886	8.25	Yes	No	0	9	7
57	R:R:D405	R:R:N619	15.2656	8.08	Yes	Yes	0	9	9
58	R:R:?546	R:R:?623	17.1734	6.55	Yes	Yes	0	9	9
59	R:R:N615	R:R:N619	12.6101	9.54	No	Yes	0	9	9
60	L:L:?111	L:L:?83	12.141	15.87	Yes	Yes	1	0	0
61	L:L:?111	L:L:?112	11.2298	30.27	Yes	Yes	1	0	0
62	L:L:?83	N:N:Q74	11.1003	9.98	Yes	Yes	1	0	0
63	L:L:?112	N:N:Q74	11.2993	5.18	Yes	Yes	1	0	0
64	L:L:H114	N:N:?113	20.3881	5.51	Yes	Yes	1	0	0
65	N:N:?113	N:N:N78	18.7913	4.41	Yes	Yes	1	0	0
66	N:N:?79	N:N:N78	14.4595	6.68	Yes	Yes	1	0	0
67	N:N:?102	N:N:V104	10.1672	4.35	Yes	Yes	5	0	0
68	N:N:T52	N:N:V104	11.2538	4.76	No	Yes	0	0	0
69	N:N:A105	N:N:T52	11.4682	3.36	No	No	0	0	0
70	N:N:?79	N:N:A105	11.6823	4.6	Yes	No	0	0	0

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:?58	R:R:A57	6.13	0	Yes	No	5	4	1	2
R:R:?58	R:R:L59	8.08	0	Yes	Yes	5	7	1	2
R:R:?58	R:R:Q82	15.53	0	Yes	Yes	5	6	1	1
N:N:?124	R:R:?58	5.62	0	Yes	Yes	0	5	0	1
R:R:?77	R:R:E102	11.86	0	No	Yes	5	7	2	1
R:R:Q82	R:R:S81	5.78	0	Yes	No	6	6	1	2
R:R:N107	R:R:Q82	7.92	0	No	Yes	7	6	1	1
L:L:T70	R:R:Q82	4.25	0	No	Yes	0	6	0	1
L:L:T70	R:R:D84	14.45	0	No	No	0	7	0	1
R:R:E102	R:R:L104	6.63	1	Yes	No	7	5	1	2
R:R:?127	R:R:E102	7.73	1	Yes	Yes	6	7	2	1
L:L:T110	R:R:E102	7.06	1	Yes	Yes	0	7	0	1
L:L:?112	R:R:E102	9.02	1	Yes	Yes	0	7	0	1
R:R:?127	R:R:L104	6.73	1	Yes	No	6	5	2	2
R:R:N107	R:R:Q106	7.92	0	No	No	7	7	1	1
N:N:D119	R:R:Q106	6.53	0	Yes	No	0	7	0	1
N:N:?121	R:R:Q106	4.64	0	No	No	0	7	0	1
L:L:M71	R:R:N107	8.41	0	No	No	0	7	0	1
R:R:?109	R:R:N110	8.19	0	No	No	6	5	1	2
R:R:?109	R:R:?134	4.32	0	No	No	6	5	1	2
L:L:L72	R:R:?109	6.61	0	No	No	0	6	0	1
R:R:?126	R:R:?127	14.46	0	Yes	Yes	5	6	1	2
R:R:?126	R:R:E148	7.11	0	Yes	No	5	5	1	1
R:R:?126	R:R:F151	6.54	0	Yes	No	5	5	1	2
L:L:?112	R:R:?126	4.82	1	Yes	Yes	0	5	0	1
R:R:?127	R:R:S129	8.76	1	Yes	No	6	7	2	2
R:R:?127	R:R:E154	9.02	1	Yes	Yes	6	7	2	1
R:R:E154	R:R:S129	14.37	1	Yes	No	7	7	1	2
R:R:?131	R:R:N132	11.76	1	Yes	Yes	7	8	2	1
R:R:?131	R:R:?156	31.75	1	Yes	Yes	7	7	2	2
R:R:?131	R:R:D157	4.36	1	Yes	Yes	7	6	2	1
R:R:D157	R:R:N132	12.12	1	Yes	Yes	6	8	1	1
L:L:L72	R:R:N132	5.49	0	No	Yes	0	8	0	1
L:L:V73	R:R:N132	7.39	0	No	Yes	0	8	0	1
R:R:N150	R:R:S149	4.47	0	No	No	5	3	1	1
R:R:E175	R:R:S149	8.62	0	No	No	5	3	2	1
L:L:?99	R:R:S149	4.48	0	Yes	No	0	3	0	1
N:N:Q66	R:R:N150	14.52	0	No	No	0	5	0	1
R:R:I152	R:R:T178	7.6	0	No	No	4	6	2	1
R:R:?156	R:R:E154	4.26	1	Yes	Yes	7	7	2	1
L:L:?115	R:R:E154	6.32	1	Yes	Yes	0	7	0	1
R:R:?156	R:R:D157	14.53	1	Yes	Yes	7	6	2	1
R:R:?156	R:R:?182	4.32	1	Yes	Yes	7	6	2	1
R:R:?156	R:R:N184	13.23	1	Yes	Yes	7	9	2	2
N:N:R115	R:R:D157	8.34	1	No	Yes	0	6	0	1
L:L:?113	R:R:T178	4.3	1	Yes	No	0	6	0	1
R:R:?182	R:R:?183	15.26	1	Yes	Yes	6	7	1	1
R:R:?182	R:R:N184	9.35	1	Yes	Yes	6	9	1	2
R:R:?182	R:R:E203	19.33	1	Yes	No	6	5	1	2
R:R:?182	R:R:?205	13.65	1	Yes	No	6	7	1	2
N:N:R115	R:R:?182	11.82	1	No	Yes	0	6	0	1
R:R:?183	R:R:N184	4.79	1	Yes	Yes	7	9	1	2
R:R:?183	R:R:N207	5.99	1	Yes	No	7	9	1	2
N:N:R115	R:R:?183	5.3	1	No	Yes	0	7	0	1
R:R:?225	R:R:Q246	7.15	0	No	No	3	6	1	2
R:R:R247	R:R:T226	9.06	0	No	No	5	4	1	2
R:R:E270	R:R:R247	9.3	0	No	No	6	5	2	1
N:N:P70	R:R:R247	11.53	0	No	No	0	5	0	1
R:R:?331	R:R:D330	11.88	0	Yes	No	1	4	1	2
R:R:?331	R:R:E332	6.44	0	Yes	No	1	4	1	2
R:R:?331	R:R:?333	6.55	0	Yes	No	1	1	1	2
R:R:?126	R:R:L125	4.13	0	Yes	Yes	5	9	1	2
L:L:?89	R:R:E148	3.87	0	Yes	No	0	5	0	1
N:N:R63	R:R:?331	3.54	0	No	Yes	0	1	0	1
R:R:?225	R:R:T226	3.52	0	No	No	3	4	1	2
L:L:S67	R:R:?58	2.92	0	No	Yes	0	5	0	1
N:N:V68	R:R:?225	2.67	0	No	No	0	3	0	1
L:L:F41	R:R:?331	2.37	0	No	Yes	0	1	0	1
L:L:V73	R:R:L159	1.49	0	No	No	0	3	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:?510	R:R:F350	7.99	0	No	No	6	8	2	1
R:R:F350	W:W:?801	6.26	0	No	Yes	8	0	1	0
R:R:P352	R:R:V601	7.07	0	No	No	9	8	2	1
R:R:?411	R:R:T446	11.47	2	Yes	No	7	8	2	2
R:R:?411	R:R:F515	5.92	2	Yes	Yes	7	9	2	1
R:R:F515	R:R:T446	5.19	2	Yes	No	9	8	1	2
R:R:?508	R:R:P516	7.99	2	Yes	No	8	9	2	1
R:R:I513	R:R:V511	4.61	0	No	No	9	9	2	2
R:R:M517	R:R:V511	6.09	0	No	No	8	9	1	2
R:R:F515	R:R:I513	8.79	2	Yes	No	9	9	1	2
R:R:F515	R:R:P516	4.33	2	Yes	No	9	9	1	1
R:R:?612	R:R:F515	10.66	0	Yes	Yes	7	9	2	1
R:R:F515	W:W:?801	12.52	2	Yes	Yes	9	0	1	0
R:R:P516	W:W:?801	6.03	2	No	Yes	9	0	1	0
R:R:M517	W:W:?801	21.8	0	No	Yes	8	0	1	0
R:R:Q525	R:R:V519	5.73	0	No	No	6	6	2	1
R:R:?527	R:R:I528	11.11	18	Yes	No	7	6	2	1
R:R:I528	W:W:?801	5.24	0	No	Yes	6	0	1	0
R:R:A589	R:R:L532	4.73	0	No	No	9	9	1	2
R:R:A589	W:W:?801	6.94	0	No	Yes	9	0	1	0
R:R:A592	W:W:?801	4.63	0	No	Yes	9	0	1	0
R:R:?595	R:R:P597	4.9	0	No	No	6	5	2	1
R:R:P597	W:W:?801	6.03	0	No	Yes	5	0	1	0
R:R:V601	W:W:?801	5.47	0	No	Yes	8	0	1	0
R:R:S604	W:W:?801	9.92	0	No	Yes	6	0	1	0
R:R:V519	W:W:?801	3.28	0	No	Yes	6	0	1	0
R:R:A349	W:W:?801	2.31	0	No	Yes	8	0	1	0
R:R:A349	R:R:D348	1.54	0	No	No	8	9	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7FIH_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	4.22
Number of Linked Nodes	740
Number of Links	868
Number of Hubs	119
Number of Links mediated by Hubs	469
Number of Communities	21
Number of Nodes involved in Communities	152
Number of Links involved in Communities	220

Path Summary
Number Of Nodes in MetaPath	71
Number Of Links MetaPath	70
Number of Shortest Paths	1087853
Length Of Smallest Path	3
Average Path Length	32.0218
Length of Longest Path	57
Minimum Path Strength	1.24
Average Path Strength	8.16162
Maximum Path Strength	29.555
Minimum Path Correlation	0.7
Average Path Correlation	0.9841
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	2.85714
Average % Of Corr. Nodes	44.7353
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	43.8754
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• regulation of biological process • cell population proliferation • regulation of cellular process • positive regulation of cell population proliferation • regulation of cell population proliferation • biological regulation • positive regulation of biological process • cellular process • positive regulation of cellular process • multicellular organismal process • system process • gonadotropin secretion • transport • signaling • hormone secretion • cell communication • localization • secretion by cell • signal release • regulation of biological quality • secretion • regulation of hormone levels • follicle-stimulating hormone secretion • cell-cell signaling • export from cell • establishment of localization • endocrine hormone secretion • endocrine process • hormone transport • phenol-containing compound metabolic process • modified amino acid metabolic process • metabolic process • hormone metabolic process • thyroid hormone generation • thyroid hormone metabolic process • developmental process • developmental growth • growth • organ growth • multicellular organism development • thyroid gland development • endocrine system development • gland development • animal organ development • anatomical structure development • system development • positive regulation of locomotion • regulation of cell motility • positive regulation of cell migration • regulation of locomotion • positive regulation of cell motility • regulation of cell migration • cell migration • cell motility • locomotion • cellular response to stimulus • response to stimulus • response to endogenous stimulus • hormone-mediated signaling pathway • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • signal transduction • cellular response to hormone stimulus • regulation of signaling • regulation of signaling receptor activity • regulation of signal transduction • regulation of molecular function • regulation of response to stimulus • regulation of cell communication • regulation of steroid biosynthetic process • steroid metabolic process • regulation of lipid metabolic process • lipid biosynthetic process • regulation of primary metabolic process • positive regulation of metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • steroid biosynthetic process • regulation of biosynthetic process • regulation of steroid metabolic process • primary metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • positive regulation of lipid biosynthetic process • positive regulation of steroid metabolic process • regulation of lipid biosynthetic process • regulation of metabolic process • lipid metabolic process • G protein-coupled receptor signaling pathway • regulation of growth • regulation of developmental growth • regulation of developmental process • negative regulation of developmental process • negative regulation of biological process • negative regulation of organ growth • negative regulation of developmental growth • negative regulation of growth • regulation of organ growth • regulation of multicellular organismal process • negative regulation of multicellular organismal process • luteinizing hormone secretion • ovulation cycle process • reproductive process • sex differentiation • development of primary female sexual characteristics • developmental process involved in reproduction • ovulation cycle • development of primary sexual characteristics • reproductive structure development • ovarian follicle development • rhythmic process • gonad development • reproductive system development • female gonad development • multicellular organismal reproductive process • female sex differentiation • follicle-stimulating hormone signaling pathway • positive regulation of DNA-templated transcription • RNA metabolic process • positive regulation of macromolecule biosynthetic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • DNA-templated transcription • regulation of RNA metabolic process • transcription by RNA polymerase II • positive regulation of macromolecule metabolic process • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • regulation of transcription by RNA polymerase II • regulation of macromolecule metabolic process • positive regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • gene expression • macromolecule biosynthetic process • nucleic acid metabolic process • positive regulation of RNA metabolic process • regulation of gene expression • positive regulation of RNA biosynthetic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • regulation of DNA-templated transcription • membrane-bounded organelle • intracellular anatomical structure • Golgi apparatus • membrane-enclosed lumen • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle lumen • Golgi lumen • intracellular organelle • cellular anatomical structure • organelle lumen • organelle • cytoplasm • protein-containing complex
Gene Ontology	Cellular Component	• membrane-bounded organelle • intracellular anatomical structure • Golgi apparatus • membrane-enclosed lumen • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle lumen • Golgi lumen • intracellular organelle • cellular anatomical structure • organelle lumen • organelle • cytoplasm • protein-containing complex • extracellular region • pituitary gonadotropin complex • extracellular space • follicle-stimulating hormone complex • hormone activity • protein binding • binding • molecular function activator activity • signaling receptor binding • molecular function regulator activity • signaling receptor regulator activity • receptor ligand activity • signaling receptor activator activity • sexual reproduction • reproductive process • multicellular organismal reproductive process • female gamete generation • gamete generation • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • response to endogenous stimulus • biological regulation • hormone-mediated signaling pathway • cell communication • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • signal transduction • cellular response to hormone stimulus • apoptotic process • cell death • programmed cell death • G protein-coupled receptor signaling pathway • cell-cell signaling • choriogonadotropin hormone receptor activity • molecular transducer activity • protein-hormone receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • choriogonadotropin hormone binding • hormone binding • peptide receptor activity • G protein-coupled peptide receptor activity • luteinizing hormone receptor activity • developmental process • multicellular organismal process • gonad development • reproductive system development • sex differentiation • animal organ development • developmental process involved in reproduction • male gonad development • male sex differentiation • multicellular organism development • development of primary male sexual characteristics • development of primary sexual characteristics • anatomical structure development • reproductive structure development • system development • tube development • seminiferous tubule development • cellular response to nitrogen compound • cellular response to gonadotropin stimulus • cellular response to luteinizing hormone stimulus • response to luteinizing hormone • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • response to gonadotropin • spermatogenesis • male gamete generation • regulation of steroid biosynthetic process • regulation of hormone biosynthetic process • regulation of hormone metabolic process • regulation of lipid metabolic process • steroid metabolic process • lipid biosynthetic process • regulation of primary metabolic process • regulation of biological quality • hormone biosynthetic process • steroid biosynthetic process • regulation of biosynthetic process • regulation of steroid hormone biosynthetic process • regulation of hormone levels • regulation of steroid metabolic process • primary metabolic process • hormone metabolic process • biosynthetic process • metabolic process • regulation of lipid biosynthetic process • regulation of metabolic process • lipid metabolic process • system process • nervous system process • cognition • genitalia development • male genitalia development • luteinizing hormone signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • uterus development • female gonad development • female sex differentiation • development of primary female sexual characteristics • ovarian follicle development • phospholipase C-activating G protein-coupled receptor signaling pathway • rhythmic process • ovulation cycle • ovulation cycle process • development of secondary male sexual characteristics • development of secondary sexual characteristics • regulation of inositol phosphate biosynthetic process • positive regulation of biological process • regulation of inositol trisphosphate biosynthetic process • alcohol metabolic process • inositol phosphate metabolic process • positive regulation of phosphate metabolic process • positive regulation of metabolic process • positive regulation of inositol trisphosphate biosynthetic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • phosphate-containing compound metabolic process • polyol biosynthetic process • inositol trisphosphate metabolic process • small molecule metabolic process • phosphorus metabolic process • regulation of carbohydrate metabolic process • positive regulation of cellular process • carbohydrate metabolic process • polyol metabolic process • regulation of alcohol biosynthetic process • positive regulation of phosphorus metabolic process • small molecule biosynthetic process • inositol trisphosphate biosynthetic process • carbohydrate biosynthetic process • positive regulation of inositol phosphate biosynthetic process • organophosphate metabolic process • organophosphate biosynthetic process • inositol phosphate biosynthetic process • alcohol biosynthetic process • regulation of phosphorus metabolic process • regulation of carbohydrate biosynthetic process • positive regulation of carbohydrate metabolic process • positive regulation of small molecule metabolic process • positive regulation of alcohol biosynthetic process • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • intracellular membraneless organelle • centrosome • microtubule organizing center • cytoskeleton • centriolar satellite • membraneless organelle • microtubule cytoskeleton • cell periphery • plasma membrane • membrane • endosome • intracellular vesicle • cytoplasmic vesicle • vesicle • G-protein beta-subunit binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • cytoskeletal protein binding • spectrin binding • protein-containing complex binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • positive regulation of cytosolic calcium ion concentration • sensory perception of chemical stimulus • sensory perception • sensory perception of taste • sensory organ development • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • response to decreased oxygen levels • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to stress • response to hypoxia • response to stress • response to oxygen levels • response to abiotic stimulus • cell population proliferation • muscle cell apoptotic process • striated muscle cell apoptotic process • cardiac muscle cell apoptotic process • photoreceptor inner segment • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor outer segment • photoreceptor cell cilium • ciliary membrane • photoreceptor outer segment membrane • bounding membrane of organelle • plasma membrane region • organelle membrane • cell projection membrane • synapse • cell junction • cell body
SCOP2	Domain Identifier	• Cystine-knot cytokines • Cystine-knot cytokines • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Cystine-knot cytokines • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	TMR
PDB Residues	R:R:?58 R:R:?113 R:R:?127 R:R:?182 R:R:?240 R:R:?254 R:R:?275 R:R:?331 R:R:?333 R:R:?359 R:R:?389 R:R:?411 R:R:?426 R:R:?427 R:R:?455 R:R:?470 R:R:?508 R:R:?527 R:R:?546 R:R:?550 R:R:?612 R:R:?623 L:L:?61 L:L:?89 L:L:?112 L:L:?113 N:N:?57 N:N:?79 N:N:?102
Environment Details	Open EMBL-EBI Page
Code	TMR
Name	2,6-dideoxy-4-S-methyl-4-thio-beta-D-ribo-hexopyranose
Synonyms	2,6-DIDEOXY-4-THIOMETHYL-BETA-D-RIBOHEXOPYRANOSIDE; 2,6-dideoxy-4-S-methyl-4-thio-beta-D-ribo-hexose; 2,6-dideoxy-4-S-methyl-4-thio-D-ribo-hexose; 2,6-dideoxy-4-S-methyl-4-thio-ribo-hexose
Identifier
Formula	C7 H14 O3 S
Molecular Weight	178.249
SMILES
PubChem	447846
Formal Charge	0
Total Atoms	25
Total Chiral Atoms	4
Total Bonds	25
Total Aromatic Bonds	0


Code	LMS
PDB Residues	R:R:?62 R:R:?77 R:R:?109 R:R:?126 R:R:?137 R:R:?143 R:R:?180 R:R:?205 R:R:?212 R:R:?225 R:R:?233 R:R:?257 R:R:?258 R:R:?339 R:R:?390 R:R:?423 R:R:?477 R:R:?510 R:R:?548 R:R:?563 R:R:?566 R:R:?569 R:R:?570 R:R:?595 R:R:?605 R:R:?628 R:R:?640 L:L:?68 L:L:?69 L:L:?75 L:L:?87 L:L:?99 L:L:?115 N:N:?22 N:N:?40 N:N:?124
Environment Details	Open EMBL-EBI Page
Code	LMS
Name	[(2r,3s,4r,5r)-5-(6-Amino-9h-Purin-9-Yl)-3,4-Dihydroxytetrahydro-2-Furanyl]Methyl Sulfamate
Synonyms	[(2r,3s,4r,5r)-5-(6-Amino-9h-Purin-9-Yl)-3,4-Dihydroxytetrahydro-2-Furanyl]Methyl Sulfamate
Identifier
Formula	C10 H14 N6 O6 S
Molecular Weight	346.32
SMILES
PubChem	97576
Formal Charge	0
Total Atoms	37
Total Chiral Atoms	4
Total Bonds	39
Total Aromatic Bonds	10


Code	GLM
PDB Residues	R:R:?71 R:R:?117 R:R:?134 R:R:?166 R:R:?171 R:R:?183 R:R:?185 R:R:?196 R:R:?216 R:R:?220 R:R:?223 R:R:?241 R:R:?334 R:R:?358 R:R:?376 R:R:?409 R:R:?424 R:R:?436 R:R:?438 R:R:?443 R:R:?489 R:R:?490 R:R:?504 R:R:?642 L:L:?46 L:L:?54 L:L:?96 L:L:?97 N:N:?42 N:N:?56 N:N:?67 N:N:?91 N:N:?95 N:N:?121 N:N:?122
Environment Details	Open EMBL-EBI Page
Code	GLM
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds


Code	CMS
PDB Residues	R:R:?131 R:R:?156 R:R:?279 R:R:?280 R:R:?336 R:R:?343 R:R:?353 R:R:?399 R:R:?407 R:R:?439 R:R:?514 R:R:?543 R:R:?545 R:R:?581 R:R:?617 R:R:?643 R:R:?644 L:L:?31 L:L:?34 L:L:?52 L:L:?55 L:L:?56 L:L:?83 L:L:?84 L:L:?106 L:L:?108 L:L:?111 N:N:?29 N:N:?43 N:N:?46 N:N:?54 N:N:?58 N:N:?77 N:N:?92 N:N:?108 N:N:?110 N:N:?113 N:N:?120 N:N:?130
Environment Details	Open EMBL-EBI Page
Code	CMS
Name	CARBAMOYL SARCOSINE
Synonyms
Identifier
Formula	C4 H8 N2 O3
Molecular Weight	132.118
SMILES
PubChem	439375
Formal Charge	0
Total Atoms	17
Total Chiral Atoms	0
Total Bonds	16
Total Aromatic Bonds	0


Code	55Z
PDB Residues	W:W:?801
Environment Details	Open EMBL-EBI Page
Code	55Z
Name	5-azanyl-N-tert-butyl-2-methylsulfanyl-4-[3-(2-morpholin-4-ylethanoylamino)phenyl]thieno[2,3-d]pyrimidine-6-carboxamide
Synonyms
Identifier
Formula	C24 H30 N6 O3 S2
Molecular Weight	514.663
SMILES
PubChem	9914457
Formal Charge	0
Total Atoms	65
Total Chiral Atoms	0
Total Bonds	68
Total Aromatic Bonds	16


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P22888
Sequence	>7FIH_nogp_Chain_R T R L S L A ?L P V ?V I P S Q A F R ?L N E V I ?I E I S Q I D S L E R I E A N A F D N L L N L S E I L I Q N T ?N L R ?I E P ?A F I N L P R L ??L S I ?N T ?I R ?F P D V T ?V F S S E S N F I L E I ?D N L H I T T I P ?N A F Q ?M N N E S V T L ?L ??N ?F E E V Q S H A F N ?T T L T S L E L ?E N V H L E ?M H N ?A F R ?A T ?P ?T L D I S S T ?L Q A L P S ? ?L E S I Q R L I A T S S ?S L ?? L P S R E T F V N L L E A T L T ?P I H ??A F R N L P D ?E ??F ?L P ?T P R ?A P E P D A F N P ?E D I M ??D F L R V L I W L I N I L A I M ?N M T V L F V L L T S R ??L T V P R F L M ?N L S F A D F ?M ? L ?L L L I A S V D S Q T ??Q ?? N H A I D W Q T ? S ??S T A ?F F T V F A S E L S V ?T L T V I T L E R W H T I T ?A I H L D Q ?L R L R H A I L I M L ?? W L F S S L I A M L P L V ?V S N ? M ?V S I ?F P M D V E T T L S Q V ?I L T I L I L N V V A F F I I ?A ??I ?I ?F A V R N P E L M A T N ?D T ?I A ??M A I L I F T D F T ?M A P I S F F A I S A A F ?V P L I T V T N S ?V L L V L F ?P I N S ?A N P F L ?A I F T ?T F Q R D F F L L L S ?F ?? ? Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6ZFZ	A	Amine	Acetylcholine (muscarinic)	M₁	Homo sapiens	77-LH-28-1	-	-	2.17	2021-10-06	doi.org/10.1016/j.cell.2021.11.001
	5OLH	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Vipadenant	Na	-	2.6	2018-01-17	doi.org/10.1038/s41598-017-18570-w
	5GLH	A	Peptide	Endothelin	ET_B	Homo sapiens	Endothelin-1	-	-	2.8	2016-09-07	doi.org/10.1038/nature19319
	7FIH	A	Protein	Glycoprotein Hormone	LH	Homo sapiens	hCG	Org43553	chim(NtGi1-Gs)/β1/γ2	3.2	2021-09-29	doi.org/10.1038/s41586-021-03924-2
	7FIH (No Gprot)	A	Protein	Glycoprotein Hormone	LH	Homo sapiens	hCG	Org43553		3.2	2021-09-29	doi.org/10.1038/s41586-021-03924-2
	7FIG	A	Protein	Glycoprotein Hormone	LH	Homo sapiens	hCG	-	chim(NtGi1L-Gs)/β1/γ2	3.9	2021-09-29	doi.org/10.1038/s41586-021-03924-2
	7FIG (No Gprot)	A	Protein	Glycoprotein Hormone	LH	Homo sapiens	hCG	-		3.9	2021-09-29	doi.org/10.1038/s41586-021-03924-2
	7FII	A	Protein	Glycoprotein Hormone	LH	Homo sapiens	hCG	-	chim(NtGi1-Gs)/β1/γ2	4.3	2021-09-29	doi.org/10.1038/s41586-021-03924-2
	7FII (No Gprot)	A	Protein	Glycoprotein Hormone	LH	Homo sapiens	hCG	-		4.3	2021-09-29	doi.org/10.1038/s41586-021-03924-2
	7FIJ	A	Protein	Glycoprotein Hormone	LH	Homo sapiens	-	-	-	3.8	2021-09-29	doi.org/10.1038/s41586-021-03924-2

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7FIH_nogp.zip

You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.

You can also read or download a guide explaining the meaning of all files and numerical data.