psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:D39	R:R:G40	3.35	No	No	0	4	5
2	R:R:A41	R:R:D39	1.54	No	No	0	5	4
3	R:R:D39	R:R:P47	1.61	No	No	0	4	1
4	R:R:G40	R:R:V61	1.84	No	No	0	5	6
5	R:R:A41	R:R:G46	1.95	No	No	0	5	3
6	R:R:P60	R:R:R43	2.88	No	No	0	5	6
7	R:R:K62	R:R:R43	13.61	No	No	0	4	6
8	R:R:C44	R:R:P45	1.88	No	Yes	10	5	5
9	R:R:C44	R:R:V63	1.71	No	Yes	0	5	4
10	R:R:C44	R:R:P65	1.88	No	Yes	10	5	6
11	R:R:P45	R:R:P47	1.95	Yes	No	0	5	1
12	R:R:I64	R:R:P45	5.08	Yes	Yes	10	7	5
13	R:R:P45	R:R:P65	11.69	Yes	Yes	10	5	6
14	R:R:G46	R:R:P47	4.06	No	No	0	3	1
15	R:R:G50	R:R:L72	5.13	No	No	0	3	7
16	R:R:L51	R:R:L54	6.92	No	No	0	5	7
17	R:R:I76	R:R:T52	13.68	No	No	0	3	3
18	R:R:K77	R:R:R53	2.48	Yes	No	0	5	2
19	R:R:K77	R:R:S55	3.06	Yes	No	4	5	4
20	R:R:E79	R:R:S55	8.62	No	No	4	5	4
21	R:R:I78	R:R:L56	8.56	Yes	Yes	1	8	6
22	R:R:I80	R:R:L56	9.99	Yes	Yes	1	8	6
23	R:R:I83	R:R:L56	11.42	Yes	Yes	1	7	6
24	R:R:A57	R:R:Q82	1.52	No	No	0	4	6
25	R:R:Q82	R:R:Y58	2.25	No	No	0	6	5
26	R:R:D84	R:R:Y58	4.6	No	No	0	7	5
27	R:R:L59	R:R:P60	4.93	No	No	0	7	5
28	R:R:I83	R:R:V61	9.22	Yes	No	1	7	6
29	R:R:L86	R:R:V61	7.45	Yes	No	1	8	6
30	R:R:K62	R:R:V63	6.07	No	Yes	0	4	4
31	R:R:L86	R:R:V63	1.49	Yes	Yes	0	8	4
32	R:R:E90	R:R:V63	1.43	No	Yes	0	6	4
33	R:R:I64	R:R:P65	3.39	Yes	Yes	10	7	6
34	R:R:F69	R:R:I64	5.02	No	Yes	0	8	7
35	R:R:I64	R:R:I89	8.83	Yes	No	0	7	8
36	R:R:A93	R:R:I64	6.5	No	Yes	0	8	7
37	R:R:A68	R:R:P65	3.74	No	Yes	0	8	6
38	R:R:Q67	R:R:S66	4.33	No	No	11	3	4
39	R:R:E90	R:R:S66	1.44	No	No	0	6	4
40	R:R:N92	R:R:S66	2.98	Yes	No	11	6	4
41	R:R:N92	R:R:Q67	7.92	Yes	No	11	6	3
42	R:R:D95	R:R:Q67	2.61	No	No	0	6	3
43	R:R:G71	R:R:R70	1.5	No	No	0	5	2
44	R:R:L72	R:R:V75	10.43	No	No	0	7	7
45	R:R:E74	R:R:N73	2.63	No	No	0	4	4
46	R:R:L97	R:R:V75	13.41	Yes	No	1	8	7
47	R:R:L100	R:R:V75	2.98	Yes	No	1	9	7
48	R:R:I76	R:R:K77	2.91	No	Yes	0	3	5
49	R:R:I76	R:R:S101	9.29	No	No	0	3	5
50	R:R:E79	R:R:K77	4.05	No	Yes	4	5	5
51	R:R:I78	R:R:I80	2.94	Yes	Yes	1	8	8
52	R:R:F94	R:R:I78	2.51	Yes	Yes	1	9	8
53	R:R:I78	R:R:L97	1.43	Yes	Yes	1	8	8
54	R:R:I78	R:R:L100	2.85	Yes	Yes	1	8	9
55	R:R:I103	R:R:I78	4.42	Yes	Yes	1	8	8
56	R:R:E79	R:R:S81	5.75	No	No	4	5	6
57	R:R:I80	R:R:I83	8.83	Yes	Yes	1	8	7
58	R:R:I105	R:R:I80	13.25	No	Yes	0	8	8
59	R:R:Q106	R:R:S81	1.44	No	No	4	7	6
60	R:R:N107	R:R:S81	1.49	No	No	4	7	6
61	R:R:I83	R:R:L86	1.43	Yes	Yes	1	7	8
62	R:R:D84	R:R:S85	2.94	No	No	0	7	5
63	R:R:I89	R:R:L86	5.71	No	Yes	0	8	8
64	R:R:E87	R:R:R88	10.47	No	No	0	5	1
65	R:R:E87	R:R:N110	18.4	No	No	0	5	5
66	R:R:R112	R:R:R88	2.13	No	No	0	5	1
67	R:R:A91	R:R:N92	3.13	No	Yes	0	5	6
68	R:R:A91	R:R:E115	1.51	No	No	0	5	5
69	R:R:G117	R:R:N92	1.7	No	Yes	0	3	6
70	R:R:I120	R:R:N92	11.33	No	Yes	0	5	6
71	R:R:A93	R:R:F94	2.77	No	Yes	0	8	9
72	R:R:F94	R:R:L97	6.09	Yes	Yes	1	9	8
73	R:R:F94	R:R:L100	2.44	Yes	Yes	1	9	9
74	R:R:F94	R:R:I103	2.51	Yes	Yes	1	9	8
75	R:R:F119	R:R:F94	15	Yes	Yes	1	8	9
76	R:R:D95	R:R:N96	9.42	No	No	0	6	5
77	R:R:L100	R:R:L97	22.14	Yes	Yes	1	9	8
78	R:R:L98	R:R:N99	6.87	No	No	0	6	5
79	R:R:L98	R:R:P123	3.28	No	No	0	6	4
80	R:R:I103	R:R:L100	4.28	Yes	Yes	1	8	9
81	R:R:E102	R:R:S101	1.44	No	No	5	7	5
82	R:R:K126	R:R:S101	6.12	No	No	5	5	5
83	R:R:E102	R:R:K126	5.4	No	No	5	7	5
84	R:R:E102	R:R:Y127	25.81	No	Yes	5	7	6
85	R:R:F119	R:R:I103	7.54	Yes	Yes	1	8	8
86	R:R:I103	R:R:L128	2.85	Yes	Yes	1	8	8
87	R:R:L104	R:R:Y127	10.55	No	Yes	5	5	6
88	R:R:L104	R:R:S129	4.5	No	No	5	5	7
89	R:R:I105	R:R:T108	4.56	No	No	0	8	8
90	R:R:I105	R:R:I130	4.42	No	No	0	8	8
91	R:R:N107	R:R:Q106	15.85	No	No	4	7	7
92	R:R:C131	R:R:Q106	10.68	Yes	No	4	7	7
93	R:R:L111	R:R:T108	2.95	Yes	No	1	7	8
94	R:R:T108	R:R:T133	4.71	No	Yes	1	8	8
95	R:R:I114	R:R:L111	4.28	No	Yes	1	8	7
96	R:R:L111	R:R:T133	4.42	Yes	Yes	1	7	8
97	R:R:I135	R:R:L111	4.28	Yes	Yes	1	7	7
98	R:R:E115	R:R:Y113	2.24	No	Yes	1	5	1
99	R:R:P116	R:R:Y113	2.78	No	Yes	1	4	1
100	R:R:I135	R:R:Y113	8.46	Yes	Yes	1	7	1
101	R:R:K137	R:R:Y113	9.55	No	Yes	0	3	1
102	R:R:I114	R:R:I135	8.83	No	Yes	1	8	7
103	R:R:I114	R:R:P139	15.24	No	Yes	1	8	9
104	R:R:E115	R:R:P116	3.14	No	No	1	5	4
105	R:R:D140	R:R:P116	4.83	No	No	0	3	4
106	R:R:G117	R:R:K143	3.49	No	No	0	3	4
107	R:R:A118	R:R:F119	2.77	No	Yes	0	7	8
108	R:R:F119	R:R:L122	9.74	Yes	Yes	1	8	8
109	R:R:F119	R:R:L128	4.87	Yes	Yes	1	8	8
110	R:R:F119	R:R:V144	6.55	Yes	Yes	1	8	7
111	R:R:I120	R:R:N121	8.5	No	No	0	5	7
112	R:R:I120	R:R:K143	1.45	No	No	0	5	4
113	R:R:L122	R:R:P123	1.64	Yes	No	0	8	4
114	R:R:L122	R:R:L125	11.07	Yes	Yes	1	8	9
115	R:R:L122	R:R:V144	7.45	Yes	Yes	1	8	7
116	R:R:L122	R:R:S146	1.5	Yes	Yes	1	8	7
117	R:R:L125	R:R:V144	1.49	Yes	Yes	1	9	7
118	R:R:L125	R:R:S146	6.01	Yes	Yes	1	9	7
119	R:R:F151	R:R:L125	8.53	Yes	Yes	1	5	9
120	R:R:K126	R:R:N150	6.99	No	No	0	5	5
121	R:R:S129	R:R:Y127	11.45	No	Yes	5	7	6
122	R:R:I152	R:R:Y127	2.42	Yes	Yes	5	4	6
123	R:R:F151	R:R:L128	2.44	Yes	Yes	1	5	8
124	R:R:L128	R:R:L153	2.77	Yes	Yes	1	8	9
125	R:R:E154	R:R:S129	2.87	No	No	5	7	7
126	R:R:I130	R:R:T133	4.56	No	Yes	0	8	8
127	R:R:I130	R:R:I155	2.94	No	Yes	0	8	8
128	R:R:C131	R:R:N132	1.57	Yes	No	4	7	8
129	R:R:C131	R:R:C156	1.82	Yes	No	4	7	7
130	R:R:C131	R:R:D157	4.67	Yes	No	4	7	6
131	R:R:D157	R:R:N132	4.04	No	No	4	6	8
132	R:R:G134	R:R:T133	1.82	No	Yes	1	5	8
133	R:R:I135	R:R:T133	3.04	Yes	Yes	1	7	8
134	R:R:N158	R:R:T133	4.39	Yes	Yes	1	9	8
135	R:R:G134	R:R:N158	1.7	No	Yes	1	5	9
136	R:R:G134	R:R:H160	7.94	No	No	0	5	3
137	R:R:I135	R:R:P139	6.77	Yes	Yes	1	7	9
138	R:R:I135	R:R:N158	5.66	Yes	Yes	1	7	9
139	R:R:I135	R:R:I161	4.42	Yes	Yes	1	7	7
140	R:R:K137	R:R:R136	2.48	No	No	0	3	3
141	R:R:H160	R:R:R136	5.64	No	No	0	3	3
142	R:R:F138	R:R:P139	8.67	Yes	Yes	1	5	9
143	R:R:F138	R:R:I161	2.51	Yes	Yes	1	5	7
144	R:R:F138	R:R:P165	5.78	Yes	No	0	5	7
145	R:R:A168	R:R:F138	2.77	No	Yes	1	7	5
146	R:R:F138	R:R:F169	4.29	Yes	Yes	1	5	6
147	R:R:F138	R:R:F186	2.14	Yes	Yes	1	5	8
148	R:R:P139	R:R:V141	1.77	Yes	No	1	9	5
149	R:R:I161	R:R:P139	1.69	Yes	Yes	1	7	9
150	R:R:D140	R:R:T142	1.45	No	No	0	3	4
151	R:R:F169	R:R:V141	2.62	Yes	No	1	6	5
152	R:R:M172	R:R:V141	4.56	Yes	No	1	6	5
153	R:R:Q170	R:R:T142	1.42	Yes	No	0	3	4
154	R:R:S146	R:R:V144	1.62	Yes	Yes	1	7	7
155	R:R:M172	R:R:V144	1.52	Yes	Yes	1	6	7
156	R:R:N173	R:R:S146	1.49	Yes	Yes	1	4	7
157	R:R:N174	R:R:S147	1.49	No	No	0	4	5
158	R:R:E148	R:R:S149	1.44	No	No	0	5	3
159	R:R:E148	R:R:N150	10.52	No	No	0	5	5
160	R:R:E175	R:R:S149	10.06	No	No	0	5	3
161	R:R:S149	R:R:S176	1.63	No	No	0	3	5
162	R:R:F151	R:R:L153	2.44	Yes	Yes	1	5	9
163	R:R:F151	R:R:M172	2.49	Yes	Yes	1	5	6
164	R:R:F151	R:R:N173	3.62	Yes	Yes	1	5	4
165	R:R:F151	R:R:V177	5.24	Yes	Yes	1	5	3
166	R:R:E154	R:R:I152	5.47	No	Yes	5	7	4
167	R:R:I152	R:R:T178	12.16	Yes	No	5	4	6
168	R:R:I152	R:R:K180	5.82	Yes	Yes	5	4	5
169	R:R:I155	R:R:L153	2.85	Yes	Yes	1	8	9
170	R:R:F169	R:R:L153	4.87	Yes	Yes	1	6	9
171	R:R:L153	R:R:L179	5.54	Yes	Yes	1	9	8
172	R:R:E154	R:R:K180	18.9	No	Yes	5	7	5
173	R:R:I155	R:R:N158	1.42	Yes	Yes	1	8	9
174	R:R:I155	R:R:L181	2.85	Yes	Yes	1	8	8
175	R:R:I155	R:R:N184	9.91	Yes	Yes	1	8	9
176	R:R:C156	R:R:D157	6.22	No	No	4	7	6
177	R:R:I161	R:R:N158	12.74	Yes	Yes	1	7	9
178	R:R:G185	R:R:L159	1.71	No	No	0	4	3
179	R:R:F186	R:R:I161	16.33	Yes	Yes	1	8	7
180	R:R:T162	R:R:T163	1.57	No	No	0	3	3
181	R:R:I164	R:R:T163	1.52	Yes	No	0	7	3
182	R:R:E188	R:R:T163	5.64	No	No	0	5	3
183	R:R:I164	R:R:P165	3.39	Yes	No	0	7	7
184	R:R:A168	R:R:I164	3.25	No	Yes	0	7	7
185	R:R:I164	R:R:V189	3.07	Yes	No	0	7	7
186	R:R:A193	R:R:I164	3.25	No	Yes	0	8	7
187	R:R:G166	R:R:P165	2.03	Yes	No	0	4	7
188	R:R:G166	R:R:N167	1.7	Yes	No	0	4	7
189	R:R:G166	R:R:Q190	1.64	Yes	No	7	4	2
190	R:R:A193	R:R:G166	1.95	No	Yes	7	8	4
191	R:R:N167	R:R:Q170	11.88	No	Yes	0	7	3
192	R:R:H192	R:R:N167	6.38	Yes	No	0	5	7
193	R:R:A168	R:R:F169	2.77	No	Yes	1	7	6
194	R:R:F169	R:R:M172	2.49	Yes	Yes	1	6	6
195	R:R:F169	R:R:L179	8.53	Yes	Yes	1	6	8
196	R:R:F169	R:R:F194	10.72	Yes	Yes	0	6	9
197	R:R:G171	R:R:Q170	1.64	No	Yes	0	4	3
198	R:R:N195	R:R:Q170	9.24	No	Yes	0	5	3
199	R:R:N173	R:R:V177	4.43	Yes	Yes	1	4	3
200	R:R:S176	R:R:T198	1.6	No	No	0	5	5
201	R:R:S176	R:R:T200	3.2	No	No	0	5	4
202	R:R:L179	R:R:V177	2.98	Yes	Yes	1	8	3
203	R:R:T197	R:R:V177	3.17	No	Yes	0	5	3
204	R:R:K180	R:R:T178	4.5	Yes	No	5	5	6
205	R:R:T178	R:R:T200	3.14	No	No	0	6	4
206	R:R:L179	R:R:L199	9.69	Yes	Yes	1	8	8
207	R:R:L179	R:R:L202	2.77	Yes	Yes	1	8	7
208	R:R:E203	R:R:K180	21.6	No	Yes	0	5	5
209	R:R:L181	R:R:N184	9.61	Yes	Yes	1	8	9
210	R:R:F186	R:R:L181	3.65	Yes	Yes	1	8	8
211	R:R:L181	R:R:L204	4.15	Yes	Yes	1	8	9
212	R:R:L181	R:R:N207	2.75	Yes	Yes	1	8	9
213	R:R:G183	R:R:Y182	1.45	No	No	6	7	6
214	R:R:K205	R:R:Y182	14.33	Yes	No	6	7	6
215	R:R:E206	R:R:Y182	7.86	Yes	No	6	4	6
216	R:R:E206	R:R:G183	1.64	Yes	No	6	4	7
217	R:R:G185	R:R:N184	1.7	No	Yes	0	4	9
218	R:R:F186	R:R:N184	9.67	Yes	Yes	1	8	9
219	R:R:N184	R:R:N207	4.09	Yes	Yes	1	9	9
220	R:R:G185	R:R:H209	3.18	No	No	0	4	1
221	R:R:F186	R:R:N207	2.42	Yes	Yes	1	8	9
222	R:R:E187	R:R:H209	17.23	No	No	0	2	1
223	R:R:E187	R:R:E211	3.81	No	No	0	2	2
224	R:R:L210	R:R:V189	2.98	Yes	No	0	8	7
225	R:R:M213	R:R:V189	4.56	No	No	0	6	7
226	R:R:Q190	R:R:S191	1.44	No	No	7	2	5
227	R:R:A193	R:R:Q190	1.52	No	No	7	8	2
228	R:R:H214	R:R:S191	16.74	No	No	7	5	5
229	R:R:G216	R:R:S191	1.86	Yes	No	7	3	5
230	R:R:H192	R:R:N195	3.83	Yes	No	0	5	5
231	R:R:H192	R:R:R219	11.28	Yes	No	12	5	1
232	R:R:G220	R:R:H192	3.18	No	Yes	12	5	5
233	R:R:F194	R:R:T197	11.67	Yes	No	0	9	5
234	R:R:F194	R:R:L199	4.87	Yes	Yes	0	9	8
235	R:R:A221	R:R:F194	5.55	No	Yes	0	8	9
236	R:R:G196	R:R:N195	5.09	No	No	0	6	5
237	R:R:G196	R:R:T197	1.82	No	No	0	6	5
238	R:R:T198	R:R:T222	10.99	No	No	0	5	3
239	R:R:L199	R:R:L202	2.77	Yes	Yes	1	8	7
240	R:R:F218	R:R:L199	3.65	Yes	Yes	1	8	8
241	R:R:L199	R:R:P224	6.57	Yes	Yes	1	8	8
242	R:R:S201	R:R:T200	6.4	No	No	0	5	4
243	R:R:K225	R:R:S201	1.53	No	No	13	3	5
244	R:R:S201	R:R:T226	6.4	No	No	13	5	4
245	R:R:L202	R:R:L204	9.69	Yes	Yes	1	7	9
246	R:R:L202	R:R:P224	1.64	Yes	Yes	1	7	8
247	R:R:L202	R:R:L227	2.77	Yes	Yes	0	7	8
248	R:R:D228	R:R:E203	5.2	Yes	No	0	9	5
249	R:R:L204	R:R:N207	2.75	Yes	Yes	1	9	9
250	R:R:L204	R:R:T232	4.42	Yes	Yes	1	9	9
251	R:R:E206	R:R:K205	13.5	Yes	Yes	6	4	7
252	R:R:D228	R:R:K205	5.53	Yes	Yes	6	9	7
253	R:R:K205	R:R:S230	9.18	Yes	Yes	6	7	9
254	R:R:K205	R:R:S231	4.59	Yes	Yes	6	7	6
255	R:R:E206	R:R:S231	5.75	Yes	Yes	6	4	6
256	R:R:L210	R:R:N207	4.12	Yes	Yes	1	8	9
257	R:R:N207	R:R:T232	2.92	Yes	Yes	1	9	9
258	R:R:L210	R:R:T232	4.42	Yes	Yes	1	8	9
259	R:R:L210	R:R:L234	5.54	Yes	Yes	1	8	7
260	R:R:L234	R:R:M213	5.65	Yes	No	0	7	6
261	R:R:M213	R:R:P238	6.71	No	No	0	6	9
262	R:R:G216	R:R:H214	1.59	Yes	No	7	3	5
263	R:R:G216	R:R:N215	1.7	Yes	No	0	3	1
264	R:R:N215	R:R:S239	4.47	No	No	0	1	4
265	R:R:G216	R:R:Y240	1.45	Yes	No	0	3	2
266	R:R:A221	R:R:F218	9.71	No	Yes	0	8	8
267	R:R:F218	R:R:G223	3.01	Yes	No	1	8	7
268	R:R:F218	R:R:P224	4.33	Yes	Yes	1	8	8
269	R:R:F218	R:R:G241	6.02	Yes	No	0	8	7
270	R:R:G220	R:R:R219	3	No	No	12	5	1
271	R:R:G223	R:R:T222	1.82	No	No	0	7	3
272	R:R:G223	R:R:P224	4.06	No	Yes	1	7	8
273	R:R:I245	R:R:P224	3.39	Yes	Yes	1	8	8
274	R:R:K225	R:R:T226	10.51	No	No	13	3	4
275	R:R:K225	R:R:Q246	4.07	No	No	0	3	6
276	R:R:R247	R:R:T226	7.76	No	No	0	5	4
277	R:R:I229	R:R:L227	1.43	Yes	Yes	0	7	8
278	R:R:I245	R:R:L227	7.14	Yes	Yes	0	8	8
279	R:R:L227	R:R:L248	2.77	Yes	Yes	0	8	9
280	R:R:D228	R:R:S230	4.42	Yes	Yes	6	9	9
281	R:R:D228	R:R:I249	16.79	Yes	No	6	9	5
282	R:R:I229	R:R:T232	7.6	Yes	Yes	1	7	9
283	R:R:I229	R:R:L234	9.99	Yes	Yes	1	7	7
284	R:R:A250	R:R:I229	3.25	Yes	Yes	1	8	7
285	R:R:I229	R:R:L256	1.43	Yes	Yes	1	7	8
286	R:R:S230	R:R:S231	3.26	Yes	Yes	6	9	6
287	R:R:I249	R:R:S230	3.1	No	Yes	6	5	9
288	R:R:S230	R:R:T251	3.2	Yes	No	0	9	4
289	R:R:S231	R:R:S252	1.63	Yes	No	0	6	7
290	R:R:L234	R:R:T232	8.84	Yes	Yes	1	7	9
291	R:R:K233	R:R:S255	9.18	No	No	0	3	4
292	R:R:Q235	R:R:S255	2.89	No	No	0	4	4
293	R:R:A236	R:R:K258	1.61	No	No	0	5	5
294	R:R:L237	R:R:P238	4.93	Yes	No	1	7	9
295	R:R:L237	R:R:L242	5.54	Yes	Yes	1	7	9
296	R:R:L237	R:R:L248	4.15	Yes	Yes	1	7	9
297	R:R:L237	R:R:P260	8.21	Yes	No	0	7	6
298	R:R:L242	R:R:P238	14.78	Yes	No	1	9	9
299	R:R:G241	R:R:Y240	1.45	No	No	0	7	2
300	R:R:G241	R:R:L242	1.71	No	Yes	0	7	9
301	R:R:I245	R:R:L242	7.14	Yes	Yes	1	8	9
302	R:R:E243	R:R:S244	10.06	No	No	0	3	4
303	R:R:F265	R:R:I245	3.77	Yes	Yes	1	7	8
304	R:R:I245	R:R:L268	1.43	Yes	Yes	1	8	6
305	R:R:N267	R:R:Q246	7.92	No	No	0	4	6
306	R:R:L269	R:R:Q246	7.99	No	No	0	4	6
307	R:R:E270	R:R:R247	11.63	No	No	0	6	5
308	R:R:A250	R:R:L248	1.58	Yes	Yes	1	8	9
309	R:R:L248	R:R:L273	4.15	Yes	Yes	1	9	7
310	R:R:I249	R:R:T272	4.56	No	No	0	5	6
311	R:R:A250	R:R:S253	3.42	Yes	No	1	8	7
312	R:R:A250	R:R:L256	1.58	Yes	Yes	1	8	8
313	R:R:A250	R:R:L273	1.58	Yes	Yes	1	8	7
314	R:R:S252	R:R:T251	4.8	No	No	0	7	4
315	R:R:T251	R:R:T272	4.71	No	No	0	4	6
316	R:R:S252	R:R:Y254	7.63	No	No	0	7	2
317	R:R:L256	R:R:S253	3	Yes	No	1	8	7
318	R:R:S253	R:R:T274	4.8	No	No	0	7	9
319	R:R:L256	R:R:L259	5.54	Yes	Yes	1	8	6
320	R:R:K257	R:R:Y275	3.58	No	No	0	7	8
321	R:R:I431	R:R:K257	1.45	No	No	0	8	7
322	R:R:K257	R:R:T435	15.02	No	No	0	7	6
323	R:R:L259	R:R:P260	4.93	Yes	No	0	6	6
324	R:R:L259	R:R:L273	8.3	Yes	Yes	1	6	7
325	R:R:H278	R:R:L259	12.86	Yes	Yes	1	9	6
326	R:R:F265	R:R:P260	7.22	Yes	No	0	7	6
327	R:R:F282	R:R:R262	3.21	Yes	No	0	8	5
328	R:R:F265	R:R:T264	5.19	Yes	No	0	7	4
329	R:R:F265	R:R:L268	4.87	Yes	Yes	1	7	6
330	R:R:F265	R:R:F282	2.14	Yes	Yes	1	7	8
331	R:R:N267	R:R:V266	2.96	No	No	0	4	4
332	R:R:A271	R:R:L268	4.73	No	Yes	0	7	6
333	R:R:F282	R:R:L268	10.96	Yes	Yes	1	8	6
334	R:R:L269	R:R:T340	7.37	No	No	0	4	4
335	R:R:E270	R:R:R342	10.47	No	No	0	6	4
336	R:R:A344	R:R:T272	3.36	No	No	0	6	6
337	R:R:H278	R:R:L273	5.14	Yes	Yes	1	9	7
338	R:R:T274	R:R:Y275	3.75	No	No	0	9	8
339	R:R:H278	R:R:Y275	4.36	Yes	No	0	9	8
340	R:R:P276	R:R:P345	3.9	No	No	0	7	9
341	R:R:N351	R:R:P276	6.52	Yes	No	0	8	7
342	R:R:H278	R:R:S277	5.58	Yes	No	0	9	8
343	R:R:C279	R:R:C343	7.28	No	No	0	9	9
344	R:R:C279	R:R:E346	1.52	No	No	14	9	4
345	R:R:C279	R:R:P347	7.53	No	No	14	9	8
346	R:R:C280	R:R:C353	3.64	No	No	15	9	9
347	R:R:C280	R:R:Y427	4.03	No	Yes	15	9	7
348	R:R:F282	R:R:P341	1.44	Yes	Yes	1	8	6
349	R:R:L285	R:R:R283	2.43	Yes	No	1	4	3
350	R:R:K339	R:R:R283	13.61	No	No	1	3	3
351	R:R:F292	R:R:N284	2.42	No	No	0	2	5
352	R:R:L285	R:R:P286	1.64	Yes	No	1	4	4
353	R:R:K339	R:R:L285	12.69	No	Yes	1	3	4
354	R:R:P286	R:R:T340	5.25	No	No	1	4	4
355	R:R:P286	R:R:P341	5.84	No	Yes	1	4	6
356	R:R:N291	R:R:T287	1.46	No	No	0	2	3
357	R:R:K288	R:R:P338	8.36	No	No	0	2	3
358	R:R:K339	R:R:P341	5.02	No	Yes	1	3	6
359	R:R:P341	R:R:T340	3.5	Yes	No	1	6	4
360	R:R:E346	R:R:P347	6.29	No	No	14	4	8
361	R:R:D348	R:R:F350	8.36	No	Yes	0	9	8
362	R:R:A349	R:R:P352	1.87	No	Yes	0	8	9
363	R:R:F350	R:R:N351	2.42	Yes	Yes	2	8	8
364	R:R:A592	R:R:F350	4.16	No	Yes	2	9	8
365	R:R:F350	R:R:K605	22.33	Yes	Yes	2	8	9
366	R:R:N351	R:R:P352	1.63	Yes	Yes	2	8	9
367	R:R:N351	R:R:V511	1.48	Yes	Yes	2	8	9
368	R:R:N351	R:R:S512	8.94	Yes	No	2	8	9
369	R:R:E354	R:R:P352	1.57	No	Yes	0	7	9
370	R:R:P352	R:R:S512	3.56	Yes	No	2	9	9
371	R:R:C353	R:R:E354	1.52	No	No	0	9	7
372	R:R:C353	R:R:Y427	2.69	No	Yes	15	9	7
373	R:R:D355	R:R:G358	1.68	Yes	No	2	7	8
374	R:R:D355	R:R:R363	3.57	Yes	No	2	7	9
375	R:R:D355	R:R:D419	13.31	Yes	Yes	2	7	9
376	R:R:D355	R:R:T422	11.56	Yes	No	0	7	9
377	R:R:D355	R:R:G424	3.35	Yes	No	0	7	7
378	R:R:I356	R:R:M357	4.37	Yes	Yes	2	8	7
379	R:R:I356	R:R:I366	1.47	Yes	No	2	8	9
380	R:R:I356	R:R:I415	2.94	Yes	No	2	8	8
381	R:R:D419	R:R:I356	2.8	Yes	Yes	2	9	8
382	R:R:I356	R:R:I513	2.94	Yes	Yes	2	8	9
383	R:R:I356	R:R:V609	1.54	Yes	Yes	2	8	9
384	R:R:M357	R:R:Y359	7.18	Yes	Yes	2	7	6
385	R:R:L362	R:R:M357	4.24	No	Yes	2	8	7
386	R:R:I366	R:R:M357	8.75	No	Yes	2	9	7
387	R:R:M357	R:R:V609	7.61	Yes	Yes	2	7	9
388	R:R:G358	R:R:Y359	1.45	No	Yes	2	8	6
389	R:R:G358	R:R:R363	6	No	No	2	8	9
390	R:R:L362	R:R:Y359	17.58	No	Yes	2	8	6
391	R:R:V606	R:R:Y359	3.79	No	Yes	0	7	6
392	R:R:D360	R:R:L362	2.71	No	No	0	4	8
393	R:R:L365	R:R:V364	1.49	No	No	0	6	6
394	R:R:L365	R:R:L610	2.77	No	No	0	6	7
395	R:R:A416	R:R:I366	3.25	No	No	2	9	9
396	R:R:L413	R:R:W367	3.42	No	Yes	0	6	9
397	R:R:A416	R:R:W367	10.37	No	Yes	2	9	9
398	R:R:D419	R:R:W367	2.23	Yes	Yes	2	9	9
399	R:R:S420	R:R:W367	11.12	No	Yes	2	5	9
400	R:R:I369	R:R:L412	2.85	Yes	Yes	2	8	8
401	R:R:I369	R:R:P613	1.69	Yes	No	2	8	9
402	R:R:I369	R:R:I614	5.89	Yes	No	2	8	8
403	R:R:C617	R:R:I369	1.64	Yes	Yes	2	9	8
404	R:R:I371	R:R:N370	7.08	No	No	0	4	6
405	R:R:I374	R:R:N370	5.66	Yes	No	0	5	6
406	R:R:L413	R:R:N370	19.22	No	No	0	6	6
407	R:R:A373	R:R:D405	1.54	Yes	Yes	2	9	9
408	R:R:A373	R:R:G409	1.95	Yes	No	0	9	9
409	R:R:A373	R:R:S616	3.42	Yes	Yes	2	9	9
410	R:R:A373	R:R:C617	1.81	Yes	Yes	2	9	9
411	R:R:I374	R:R:N377	5.66	Yes	Yes	2	5	9
412	R:R:I374	R:R:M378	1.46	Yes	No	2	5	3
413	R:R:F406	R:R:I374	2.51	No	Yes	2	4	5
414	R:R:G376	R:R:M375	3.49	No	No	0	7	2
415	R:R:G376	R:R:T379	1.82	No	No	0	7	4
416	R:R:G376	R:R:P620	2.03	No	Yes	0	7	9
417	R:R:M378	R:R:N377	5.61	No	Yes	2	3	9
418	R:R:D405	R:R:N377	9.42	Yes	Yes	2	9	9
419	R:R:F406	R:R:N377	20.54	No	Yes	2	4	9
420	R:R:T379	R:R:V383	1.59	No	Yes	2	4	7
421	R:R:F634	R:R:T379	3.89	Yes	No	2	5	4
422	R:R:L384	R:R:V380	4.47	Yes	Yes	2	6	9
423	R:R:S402	R:R:V380	8.08	No	Yes	2	8	9
424	R:R:P620	R:R:V380	1.77	Yes	Yes	0	9	9
425	R:R:V380	R:R:Y623	5.05	Yes	Yes	2	9	9
426	R:R:F403	R:R:L381	3.65	No	No	0	5	5
427	R:R:F630	R:R:V383	14.42	Yes	Yes	2	8	7
428	R:R:D633	R:R:V383	11.69	Yes	Yes	2	8	7
429	R:R:F634	R:R:V383	3.93	Yes	Yes	2	5	7
430	R:R:C399	R:R:L384	7.94	No	Yes	0	8	6
431	R:R:L384	R:R:S402	3	Yes	No	2	6	8
432	R:R:L384	R:R:Y623	3.52	Yes	Yes	2	6	9
433	R:R:D633	R:R:T386	1.45	Yes	No	2	8	5
434	R:R:L637	R:R:T386	2.95	No	No	2	7	5
435	R:R:R395	R:R:S387	7.91	Yes	No	2	7	7
436	R:R:S387	R:R:T629	1.6	No	No	2	7	6
437	R:R:D633	R:R:S387	1.47	Yes	No	2	8	7
438	R:R:R395	R:R:Y389	3.09	Yes	No	0	7	3
439	R:R:L391	R:R:R395	4.86	No	Yes	0	5	7
440	R:R:F396	R:R:L391	10.96	No	No	0	7	5
441	R:R:C399	R:R:L391	1.59	No	No	0	8	5
442	R:R:P394	R:R:T392	6.99	No	No	0	6	8
443	R:R:R395	R:R:T392	7.76	Yes	No	0	7	8
444	R:R:P394	R:R:V393	3.53	No	No	3	6	8
445	R:R:E463	R:R:V393	4.28	Yes	No	3	9	8
446	R:R:A483	R:R:V393	5.09	No	No	0	7	8
447	R:R:E463	R:R:P394	6.29	Yes	No	3	9	6
448	R:R:M398	R:R:R395	4.96	Yes	Yes	2	7	7
449	R:R:R395	R:R:T629	14.23	Yes	No	2	7	6
450	R:R:F396	R:R:M487	11.2	No	Yes	0	7	7
451	R:R:L397	R:R:T456	2.95	Yes	Yes	3	7	8
452	R:R:L397	R:R:V459	8.94	Yes	No	3	7	4
453	R:R:I460	R:R:L397	12.85	Yes	Yes	3	9	7
454	R:R:E463	R:R:L397	2.65	Yes	Yes	3	9	7
455	R:R:K570	R:R:M398	2.88	No	Yes	0	9	7
456	R:R:M398	R:R:Y623	17.96	Yes	Yes	2	7	9
457	R:R:M398	R:R:T627	3.01	Yes	No	2	7	9
458	R:R:L452	R:R:N400	4.12	Yes	Yes	3	7	7
459	R:R:N400	R:R:T456	5.85	Yes	Yes	3	7	8
460	R:R:M487	R:R:N400	5.61	Yes	Yes	0	7	7
461	R:R:N400	R:R:W491	5.65	Yes	Yes	3	7	5
462	R:R:L401	R:R:T456	11.79	Yes	Yes	3	8	8
463	R:R:I460	R:R:L401	1.43	Yes	Yes	3	9	8
464	R:R:L401	R:R:L574	12.46	Yes	Yes	3	8	9
465	R:R:L401	R:R:N619	2.75	Yes	No	3	8	9
466	R:R:D405	R:R:S402	1.47	Yes	No	2	9	8
467	R:R:F403	R:R:W491	4.01	No	Yes	0	5	5
468	R:R:A404	R:R:L452	4.73	No	Yes	0	8	7
469	R:R:A404	R:R:S453	1.71	No	No	0	8	8
470	R:R:D405	R:R:S616	4.42	Yes	Yes	2	9	9
471	R:R:D405	R:R:P620	11.27	Yes	Yes	0	9	9
472	R:R:C407	R:R:F445	13.97	No	No	0	7	7
473	R:R:A449	R:R:C407	1.81	No	No	0	8	7
474	R:R:G409	R:R:M408	1.75	No	Yes	0	9	8
475	R:R:A449	R:R:M408	4.83	No	Yes	0	8	8
476	R:R:M408	R:R:S453	1.53	Yes	No	0	8	8
477	R:R:M408	R:R:N615	5.61	Yes	No	2	8	9
478	R:R:M408	R:R:S616	6.13	Yes	Yes	2	8	9
479	R:R:G409	R:R:L412	1.71	No	Yes	0	9	8
480	R:R:F445	R:R:L410	3.65	No	No	0	7	4
481	R:R:L412	R:R:Y411	2.34	Yes	Yes	2	8	7
482	R:R:I415	R:R:Y411	14.51	No	Yes	2	8	7
483	R:R:A442	R:R:Y411	2.67	No	Yes	2	8	7
484	R:R:T446	R:R:Y411	11.24	Yes	Yes	2	8	7
485	R:R:F515	R:R:Y411	2.06	Yes	Yes	2	9	7
486	R:R:L412	R:R:P613	9.85	Yes	No	2	8	9
487	R:R:L414	R:R:S417	4.5	No	No	0	4	4
488	R:R:L414	R:R:V418	1.49	No	No	0	4	7
489	R:R:A442	R:R:I415	1.62	No	No	2	8	8
490	R:R:A416	R:R:D419	1.54	No	Yes	2	9	9
491	R:R:V418	R:R:W433	23.29	No	Yes	0	7	9
492	R:R:D419	R:R:S420	2.94	Yes	No	2	9	5
493	R:R:T422	R:R:Y426	6.24	No	Yes	0	9	9
494	R:R:Q425	R:R:Y427	2.25	No	Yes	0	4	7
495	R:R:H429	R:R:Y426	7.62	No	Yes	0	6	9
496	R:R:A430	R:R:Y426	5.34	No	Yes	8	9	9
497	R:R:W433	R:R:Y426	9.65	Yes	Yes	8	9	9
498	R:R:Q434	R:R:Y426	3.38	Yes	Yes	8	9	9
499	R:R:N428	R:R:Y427	2.33	No	Yes	0	6	7
500	R:R:I431	R:R:N428	1.42	No	No	0	8	6
501	R:R:A430	R:R:Q434	3.03	No	Yes	8	9	9
502	R:R:Q434	R:R:W433	4.38	Yes	Yes	8	9	9
503	R:R:G438	R:R:W433	2.81	No	Yes	0	8	9
504	R:R:C439	R:R:W433	13.06	No	Yes	8	9	9
505	R:R:C514	R:R:W433	9.14	No	Yes	8	9	9
506	R:R:C439	R:R:Q434	7.63	No	Yes	8	9	9
507	R:R:M509	R:R:Q434	6.8	No	Yes	0	6	9
508	R:R:C514	R:R:Q434	4.58	No	Yes	8	9	9
509	R:R:G436	R:R:T435	1.82	No	No	0	9	6
510	R:R:S437	R:R:T441	1.6	No	No	0	2	3
511	R:R:C439	R:R:C514	7.28	No	No	8	9	9
512	R:R:L502	R:R:S440	1.5	Yes	No	2	7	4
513	R:R:S440	R:R:Y508	15.26	No	Yes	2	4	8
514	R:R:F444	R:R:T441	9.08	No	No	0	8	3
515	R:R:A442	R:R:G443	1.95	No	Yes	2	8	9
516	R:R:G443	R:R:T446	3.64	Yes	Yes	2	9	8
517	R:R:G443	R:R:Y508	1.45	Yes	Yes	2	9	8
518	R:R:G443	R:R:P516	4.06	Yes	Yes	2	9	9
519	R:R:A498	R:R:F444	4.16	No	No	0	9	8
520	R:R:F444	R:R:L502	2.44	No	Yes	0	8	7
521	R:R:F445	R:R:F448	3.22	No	Yes	0	7	8
522	R:R:T446	R:R:V447	3.17	Yes	No	2	8	8
523	R:R:F515	R:R:T446	10.38	Yes	Yes	2	9	8
524	R:R:P516	R:R:T446	1.75	Yes	Yes	2	9	8
525	R:R:T446	R:R:Y612	2.5	Yes	Yes	0	8	7
526	R:R:I497	R:R:V447	3.07	Yes	No	0	5	8
527	R:R:P516	R:R:V447	3.53	Yes	No	2	9	8
528	R:R:F448	R:R:W491	7.02	Yes	Yes	0	8	5
529	R:R:F448	R:R:S494	7.93	Yes	No	0	8	7
530	R:R:F448	R:R:S495	3.96	Yes	No	0	8	3
531	R:R:A498	R:R:F448	4.16	No	Yes	0	9	8
532	R:R:S450	R:R:Y612	3.82	No	Yes	0	8	7
533	R:R:E451	R:R:S494	4.31	No	No	0	9	7
534	R:R:E451	R:R:I497	16.4	No	Yes	0	9	5
535	R:R:L452	R:R:T456	4.42	Yes	Yes	3	7	8
536	R:R:L452	R:R:W491	21.64	Yes	Yes	3	7	5
537	R:R:L452	R:R:S494	3	Yes	No	0	7	7
538	R:R:T458	R:R:V454	1.59	Yes	No	3	8	7
539	R:R:A538	R:R:V454	1.7	No	No	3	9	7
540	R:R:V459	R:R:Y455	3.79	No	Yes	3	4	8
541	R:R:I486	R:R:Y455	3.63	No	Yes	3	5	8
542	R:R:G490	R:R:Y455	11.59	No	Yes	3	8	8
543	R:R:F493	R:R:Y455	2.06	No	Yes	3	5	8
544	R:R:I460	R:R:T456	3.04	Yes	Yes	3	9	8
545	R:R:I542	R:R:L457	14.27	Yes	Yes	3	8	9
546	R:R:L457	R:R:L574	5.54	Yes	Yes	3	9	9
547	R:R:I575	R:R:L457	7.14	Yes	Yes	3	9	9
548	R:R:D578	R:R:L457	8.14	No	Yes	3	8	9
549	R:R:A538	R:R:T458	1.68	No	Yes	3	9	8
550	R:R:I541	R:R:T458	1.52	Yes	Yes	3	4	8
551	R:R:I542	R:R:T458	1.52	Yes	Yes	3	8	8
552	R:R:I486	R:R:V459	1.54	No	No	3	5	4
553	R:R:I460	R:R:R464	3.76	Yes	Yes	3	9	8
554	R:R:I460	R:R:M571	4.37	Yes	Yes	3	9	8
555	R:R:I460	R:R:L574	1.43	Yes	Yes	3	9	9
556	R:R:L462	R:R:T461	1.47	No	Yes	3	5	8
557	R:R:I541	R:R:T461	3.04	Yes	Yes	3	4	8
558	R:R:I542	R:R:T461	12.16	Yes	Yes	3	8	8
559	R:R:C545	R:R:T461	10.14	Yes	Yes	3	6	8
560	R:R:M571	R:R:T461	1.51	Yes	Yes	3	8	8
561	R:R:L462	R:R:W465	3.42	No	Yes	3	5	5
562	R:R:C545	R:R:L462	1.59	Yes	No	3	6	5
563	R:R:E463	R:R:R464	2.33	Yes	Yes	3	9	8
564	R:R:I549	R:R:R464	16.28	Yes	Yes	0	9	8
565	R:R:I567	R:R:R464	3.76	No	Yes	0	7	8
566	R:R:M571	R:R:R464	23.57	Yes	Yes	3	8	8
567	R:R:T469	R:R:W465	12.13	No	Yes	3	5	5
568	R:R:W465	R:R:Y470	15.43	Yes	Yes	3	5	3
569	R:R:C545	R:R:W465	2.61	Yes	Yes	3	6	5
570	R:R:K548	R:R:W465	8.12	No	Yes	0	4	5
571	R:R:H466	R:R:Y470	9.8	No	Yes	0	5	3
572	R:R:H466	R:R:L478	5.14	No	No	0	5	4
573	R:R:I468	R:R:T467	1.52	No	No	0	7	8
574	R:R:I468	R:R:I549	10.3	No	Yes	0	7	9
575	R:R:D564	R:R:I468	4.2	No	No	0	8	7
576	R:R:T469	R:R:Y470	6.24	No	Yes	3	5	3
577	R:R:A552	R:R:T469	5.03	No	No	0	5	5
578	R:R:A471	R:R:E557	3.02	No	No	0	6	4
579	R:R:A471	R:R:L558	1.58	No	No	0	6	4
580	R:R:H473	R:R:I472	6.63	No	No	0	4	5
581	R:R:E557	R:R:I472	16.4	No	No	0	4	5
582	R:R:H473	R:R:Q476	7.42	No	No	0	4	5
583	R:R:H482	R:R:L478	10.29	No	No	0	5	4
584	R:R:H482	R:R:R479	11.28	No	No	0	5	5
585	R:R:A483	R:R:M487	1.61	No	Yes	0	7	7
586	R:R:I484	R:R:M487	2.92	No	Yes	0	3	7
587	R:R:G489	R:R:L488	1.71	No	No	0	3	1
588	R:R:G489	R:R:G490	2.11	No	No	0	3	8
589	R:R:G489	R:R:L492	1.71	No	No	0	3	1
590	R:R:F493	R:R:G490	3.01	No	No	3	5	8
591	R:R:L492	R:R:S495	4.5	No	No	0	1	3
592	R:R:L496	R:R:L500	4.15	No	Yes	0	3	5
593	R:R:I497	R:R:Y527	8.46	Yes	No	0	5	7
594	R:R:I497	R:R:I531	1.47	Yes	No	0	5	6
595	R:R:L502	R:R:M499	5.65	Yes	No	0	7	3
596	R:R:L500	R:R:P501	1.64	Yes	No	0	5	9
597	R:R:L500	R:R:V505	5.96	Yes	No	16	5	5
598	R:R:L500	R:R:Y527	10.55	Yes	No	16	5	7
599	R:R:P501	R:R:S506	5.34	No	No	0	9	8
600	R:R:P501	R:R:Y508	2.78	No	Yes	0	9	8
601	R:R:L502	R:R:Y508	2.34	Yes	Yes	2	7	8
602	R:R:G504	R:R:V503	1.84	No	No	0	6	4
603	R:R:V505	R:R:Y527	3.79	No	No	16	5	7
604	R:R:P516	R:R:S506	1.78	Yes	No	0	9	8
605	R:R:N507	R:R:Y508	3.49	No	Yes	0	7	8
606	R:R:M509	R:R:N507	15.43	No	No	0	6	7
607	R:R:D518	R:R:N507	2.69	Yes	No	0	7	7
608	R:R:P516	R:R:Y508	2.78	Yes	Yes	2	9	8
609	R:R:D518	R:R:K510	4.15	Yes	No	0	7	6
610	R:R:I513	R:R:V511	6.14	Yes	Yes	2	9	9
611	R:R:M517	R:R:V511	6.09	Yes	Yes	2	8	9
612	R:R:K605	R:R:V511	3.04	Yes	Yes	2	9	9
613	R:R:F515	R:R:I513	2.51	Yes	Yes	2	9	9
614	R:R:I513	R:R:V609	1.54	Yes	Yes	2	9	9
615	R:R:F515	R:R:P516	13	Yes	Yes	2	9	9
616	R:R:F515	R:R:M517	4.98	Yes	Yes	2	9	8
617	R:R:A589	R:R:M517	1.61	No	Yes	2	9	8
618	R:R:A592	R:R:M517	1.61	No	Yes	2	9	8
619	R:R:K605	R:R:M517	4.32	Yes	Yes	2	9	8
620	R:R:L608	R:R:M517	2.83	No	Yes	2	8	8
621	R:R:D518	R:R:E520	6.5	Yes	No	0	7	5
622	R:R:D518	R:R:S524	5.89	Yes	No	0	7	7
623	R:R:Q525	R:R:V519	5.73	No	No	0	6	6
624	R:R:I528	R:R:V519	1.54	No	No	17	6	6
625	R:R:A593	R:R:V519	1.7	No	No	17	7	6
626	R:R:L523	R:R:T521	2.95	No	No	0	4	5
627	R:R:S524	R:R:T521	4.8	No	No	0	7	5
628	R:R:T522	R:R:V526	1.59	No	No	0	4	4
629	R:R:T530	R:R:V526	1.59	Yes	No	0	4	4
630	R:R:A593	R:R:I528	1.62	No	No	17	7	6
631	R:R:L529	R:R:T530	1.47	No	Yes	0	6	4
632	R:R:I533	R:R:T530	3.04	No	Yes	18	6	4
633	R:R:L534	R:R:T530	2.95	No	Yes	18	5	4
634	R:R:L532	R:R:N535	2.75	Yes	No	19	9	9
635	R:R:L532	R:R:V536	2.98	Yes	No	19	9	7
636	R:R:L532	R:R:S586	1.5	Yes	No	0	9	9
637	R:R:I590	R:R:L532	5.71	No	Yes	0	7	9
638	R:R:I533	R:R:L534	1.43	No	No	18	6	5
639	R:R:I533	R:R:V537	1.54	No	No	0	6	4
640	R:R:N535	R:R:V536	4.43	No	No	19	9	7
641	R:R:C543	R:R:F539	8.38	No	No	0	7	8
642	R:R:F539	R:R:I575	3.77	No	Yes	0	8	9
643	R:R:F539	R:R:F579	21.43	No	Yes	0	8	8
644	R:R:I541	R:R:I542	1.47	Yes	Yes	3	4	8
645	R:R:C545	R:R:I541	3.27	Yes	Yes	3	6	4
646	R:R:I542	R:R:I575	2.94	Yes	Yes	3	8	9
647	R:R:I549	R:R:Y546	3.63	Yes	No	0	9	9
648	R:R:Y546	R:R:Y550	10.92	No	No	0	9	9
649	R:R:M571	R:R:Y546	7.18	Yes	No	0	8	9
650	R:R:A568	R:R:I549	1.62	No	Yes	0	8	9
651	R:R:F551	R:R:Y550	2.06	No	No	0	4	9
652	R:R:A552	R:R:P556	5.61	No	No	0	5	6
653	R:R:M559	R:R:V553	3.04	No	No	0	2	7
654	R:R:M559	R:R:R554	14.89	No	No	0	2	5
655	R:R:N555	R:R:P556	1.63	No	No	0	7	6
656	R:R:M559	R:R:T561	1.51	No	No	0	2	4
657	R:R:A560	R:R:D564	4.63	No	No	0	3	8
658	R:R:N562	R:R:T561	1.46	No	No	0	4	4
659	R:R:K628	R:R:N562	5.6	No	No	0	7	4
660	R:R:K566	R:R:K628	12.93	No	No	0	5	7
661	R:R:I573	R:R:K569	1.45	Yes	No	9	5	7
662	R:R:F626	R:R:K569	26.06	Yes	No	9	8	7
663	R:R:I573	R:R:K570	2.91	Yes	No	0	5	9
664	R:R:K570	R:R:L574	5.64	No	Yes	0	9	9
665	R:R:A572	R:R:I575	1.62	No	Yes	0	9	9
666	R:R:I573	R:R:T577	1.52	Yes	No	9	5	9
667	R:R:I573	R:R:L622	12.85	Yes	Yes	9	5	9
668	R:R:F626	R:R:I573	11.3	Yes	Yes	9	8	5
669	R:R:L574	R:R:N619	5.49	Yes	No	3	9	9
670	R:R:F576	R:R:I575	8.79	No	Yes	0	8	9
671	R:R:D578	R:R:I575	2.8	No	Yes	3	8	9
672	R:R:A618	R:R:T577	1.68	No	No	0	7	9
673	R:R:L622	R:R:T577	1.47	Yes	No	9	9	9
674	R:R:D578	R:R:F579	2.39	No	Yes	0	8	8
675	R:R:A583	R:R:F579	2.77	No	Yes	0	8	8
676	R:R:C581	R:R:I614	4.91	No	No	0	9	8
677	R:R:C581	R:R:N615	3.15	No	No	0	9	9
678	R:R:M582	R:R:S586	3.07	No	No	0	7	9
679	R:R:M582	R:R:Y612	8.38	No	Yes	0	7	7
680	R:R:A583	R:R:P584	1.87	No	No	0	8	9
681	R:R:F588	R:R:P584	1.44	No	No	0	8	9
682	R:R:I585	R:R:L607	1.43	Yes	No	2	9	8
683	R:R:I585	R:R:L608	5.71	Yes	No	2	9	8
684	R:R:F611	R:R:I585	2.51	No	Yes	2	8	9
685	R:R:I585	R:R:Y612	14.51	Yes	Yes	0	9	7
686	R:R:F587	R:R:I590	3.77	No	No	0	7	7
687	R:R:F588	R:R:L598	3.65	No	No	0	8	7
688	R:R:F588	R:R:L607	9.74	No	No	0	8	8
689	R:R:A589	R:R:L608	4.73	No	No	2	9	8
690	R:R:I590	R:R:S591	1.55	No	No	0	7	8
691	R:R:L598	R:R:S591	4.5	No	No	0	7	8
692	R:R:A592	R:R:K605	1.61	No	Yes	2	9	9
693	R:R:P597	R:R:V596	3.53	No	No	0	5	5
694	R:R:P597	R:R:V601	1.77	No	No	0	5	8
695	R:R:I599	R:R:L598	4.28	No	No	0	8	7
696	R:R:I599	R:R:T600	1.52	No	No	20	8	8
697	R:R:I599	R:R:N603	1.42	No	No	20	8	6
698	R:R:T600	R:R:T602	4.71	No	No	0	8	7
699	R:R:N603	R:R:T600	8.77	No	No	20	6	8
700	R:R:T602	R:R:V601	1.59	No	No	0	7	8
701	R:R:N603	R:R:V606	2.96	No	No	0	6	7
702	R:R:K605	R:R:S604	1.53	Yes	No	0	9	6
703	R:R:K605	R:R:V609	1.52	Yes	Yes	2	9	9
704	R:R:F611	R:R:L607	6.09	No	No	2	8	8
705	R:R:F611	R:R:L610	3.65	No	No	0	8	7
706	R:R:P613	R:R:Y612	4.17	No	Yes	0	9	7
707	R:R:C617	R:R:I614	3.27	Yes	No	2	9	8
708	R:R:N615	R:R:S616	1.49	No	Yes	2	9	9
709	R:R:C617	R:R:S616	1.72	Yes	Yes	2	9	9
710	R:R:N619	R:R:P620	9.77	No	Yes	0	9	9
711	R:R:F626	R:R:L622	2.44	Yes	Yes	9	8	9
712	R:R:T627	R:R:Y623	18.73	No	Yes	2	9	9
713	R:R:F630	R:R:Y623	10.32	Yes	Yes	2	8	9
714	R:R:A624	R:R:F630	4.16	No	Yes	0	7	8
715	R:R:F626	R:R:I625	7.54	Yes	No	0	8	7
716	R:R:F630	R:R:T627	6.49	Yes	No	2	8	9
717	R:R:K628	R:R:Q631	2.71	No	No	0	7	6
718	R:R:F630	R:R:F634	5.36	Yes	Yes	2	8	5
719	R:R:D633	R:R:F634	3.58	Yes	Yes	2	8	5
720	R:R:D633	R:R:L637	2.71	Yes	No	2	8	7
721	R:R:F641	R:R:L637	4.87	No	No	0	2	7
722	R:R:C643	R:R:L638	11.11	No	No	21	2	4
723	R:R:C644	R:R:L638	6.35	No	No	21	4	4
724	R:R:C644	R:R:S639	3.44	No	No	0	4	5
725	R:R:C643	R:R:C644	1.82	No	No	21	2	4
726	R:R:E74	R:R:T52	1.41	No	No	0	4	3
727	R:R:E243	R:R:T264	1.41	No	No	0	3	4
728	R:R:L372	R:R:M375	1.41	No	No	0	5	2
729	R:R:K477	R:R:L474	1.41	No	No	0	5	3
730	R:R:K640	R:R:L636	1.41	No	No	0	4	3
731	R:R:K109	R:R:N132	1.4	No	No	0	6	8
732	R:R:C343	R:R:F282	1.4	No	Yes	0	9	8
733	R:R:D432	R:R:I431	1.4	No	No	0	4	8
734	R:R:K563	R:R:N562	1.4	No	No	0	5	4
735	R:R:L54	R:R:L56	1.38	No	Yes	0	7	6
736	R:R:D564	R:R:K563	1.38	No	No	0	8	5
737	R:R:N173	R:R:N174	1.36	Yes	No	0	4	4
738	R:R:E211	R:R:K212	1.35	No	No	0	2	2
739	R:R:E289	R:R:K288	1.35	No	No	0	1	2
740	R:R:A281	R:R:Y427	1.33	No	Yes	0	8	7
741	R:R:H466	R:R:K477	1.31	No	No	0	5	5
742	R:R:F540	R:R:V536	1.31	No	No	0	4	7
743	R:R:F594	R:R:V596	1.31	No	No	0	6	5
744	R:R:F292	R:R:T287	1.3	No	No	0	2	3
745	R:R:F579	R:R:T580	1.3	Yes	No	0	8	6
746	R:R:F551	R:R:I547	1.26	No	No	0	4	5
747	R:R:I484	R:R:R481	1.25	No	No	0	3	3
748	R:R:F292	R:R:L285	1.22	No	Yes	0	2	4
749	R:R:F621	R:R:L622	1.22	No	Yes	0	8	9
750	R:R:L111	R:R:R88	1.21	Yes	No	0	7	1
751	R:R:L480	R:R:R479	1.21	No	No	0	3	5
752	R:R:E263	R:R:R262	1.16	No	No	0	4	5
753	R:R:H473	R:R:Y470	1.09	No	Yes	0	4	3
754	R:R:F634	R:R:F635	1.07	Yes	No	0	5	4
755	R:R:R388	R:R:Y389	1.03	No	No	0	5	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:P45	5.15	4	10	5
2	R:R:L56	7.8375	4	1	6
3	R:R:V63	2.675	4	0	4
4	R:R:I64	5.764	5	10	7
5	R:R:P65	5.175	4	10	6
6	R:R:K77	3.125	4	4	5
7	R:R:I78	3.785	6	1	8
8	R:R:I80	8.7525	4	1	8
9	R:R:I83	7.725	4	1	7
10	R:R:L86	4.02	4	1	8
11	R:R:N92	5.412	5	11	6
12	R:R:F94	5.22	6	1	9
13	R:R:L97	10.7675	4	1	8
14	R:R:L100	6.938	5	1	9
15	R:R:I103	4.32	5	1	8
16	R:R:L111	3.428	5	1	7
17	R:R:Y113	5.7575	4	1	1
18	R:R:F119	7.745	6	1	8
19	R:R:L122	6.28	5	1	8
20	R:R:L125	6.775	4	1	9
21	R:R:Y127	12.5575	4	5	6
22	R:R:L128	3.2325	4	1	8
23	R:R:C131	4.685	4	4	7
24	R:R:T133	3.82333	6	1	8
25	R:R:I135	5.92286	7	1	7
26	R:R:F138	4.36	6	1	5
27	R:R:P139	6.828	5	1	9
28	R:R:V144	3.726	5	1	7
29	R:R:S146	2.655	4	1	7
30	R:R:F151	4.12667	6	1	5
31	R:R:I152	6.4675	4	5	4
32	R:R:L153	3.694	5	1	9
33	R:R:I155	3.994	5	1	8
34	R:R:N158	5.182	5	1	9
35	R:R:I161	7.538	5	1	7
36	R:R:I164	2.896	5	0	7
37	R:R:G166	1.83	4	7	4
38	R:R:F169	5.18429	7	1	6
39	R:R:Q170	6.045	4	0	3
40	R:R:M172	2.765	4	1	6
41	R:R:N173	2.725	4	1	4
42	R:R:V177	3.955	4	1	3
43	R:R:L179	5.902	5	1	8
44	R:R:K180	12.705	4	5	5
45	R:R:L181	4.602	5	1	8
46	R:R:N184	6.996	5	1	9
47	R:R:F186	6.842	5	1	8
48	R:R:H192	6.1675	4	12	5
49	R:R:F194	8.2025	4	0	9
50	R:R:L199	5.51	5	1	8
51	R:R:L202	3.928	5	1	7
52	R:R:L204	5.2525	4	1	9
53	R:R:K205	9.426	5	6	7
54	R:R:E206	7.1875	4	6	4
55	R:R:N207	3.175	6	1	9
56	R:R:L210	4.265	4	1	8
57	R:R:G216	1.65	4	7	3
58	R:R:F218	5.344	5	1	8
59	R:R:P224	3.998	5	1	8
60	R:R:L227	3.5275	4	0	8
61	R:R:D228	7.985	4	6	9
62	R:R:I229	4.74	5	1	7
63	R:R:S230	4.632	5	6	9
64	R:R:S231	3.8075	4	6	6
65	R:R:T232	5.64	5	1	9
66	R:R:L234	7.505	4	1	7
67	R:R:L237	5.7075	4	1	7
68	R:R:L242	7.2925	4	1	9
69	R:R:I245	4.574	5	1	8
70	R:R:L248	3.1625	4	1	9
71	R:R:A250	2.282	5	1	8
72	R:R:L256	2.8875	4	1	8
73	R:R:L259	7.9075	4	1	6
74	R:R:F265	4.638	5	1	7
75	R:R:L268	5.4975	4	1	6
76	R:R:L273	4.7925	4	1	7
77	R:R:H278	6.985	4	1	9
78	R:R:F282	3.83	5	1	8
79	R:R:L285	4.495	4	1	4
80	R:R:P341	3.95	4	1	6
81	R:R:F350	9.3175	4	2	8
82	R:R:N351	4.198	5	2	8
83	R:R:P352	2.1575	4	2	9
84	R:R:D355	6.694	5	2	7
85	R:R:I356	2.67667	6	2	8
86	R:R:M357	6.43	5	2	7
87	R:R:Y359	7.5	4	2	6
88	R:R:W367	6.785	4	2	9
89	R:R:I369	3.0175	4	2	8
90	R:R:A373	2.18	4	2	9
91	R:R:I374	3.8225	4	2	5
92	R:R:N377	10.3075	4	2	9
93	R:R:V380	4.8425	4	2	9
94	R:R:V383	7.9075	4	2	7
95	R:R:L384	4.7325	4	2	6
96	R:R:R395	7.135	6	2	7
97	R:R:L397	6.8475	4	3	7
98	R:R:M398	7.2025	4	2	7
99	R:R:N400	5.3075	4	3	7
100	R:R:L401	7.1075	4	3	8
101	R:R:D405	5.624	5	2	9
102	R:R:M408	3.97	5	2	8
103	R:R:Y411	6.564	5	2	7
104	R:R:L412	4.1875	4	2	8
105	R:R:D419	4.564	5	2	9
106	R:R:Y426	6.446	5	8	9
107	R:R:Y427	2.526	5	15	7
108	R:R:W433	10.3883	6	8	9
109	R:R:Q434	4.96667	6	8	9
110	R:R:G443	2.775	4	2	9
111	R:R:T446	5.44667	6	2	8
112	R:R:F448	5.258	5	0	8
113	R:R:L452	7.582	5	3	7
114	R:R:Y455	5.2675	4	3	8
115	R:R:T456	5.61	5	3	8
116	R:R:L457	8.7725	4	3	9
117	R:R:T458	1.5775	4	3	8
118	R:R:I460	4.48	6	3	9
119	R:R:T461	5.664	5	3	8
120	R:R:E463	3.8875	4	3	9
121	R:R:R464	9.94	5	3	8
122	R:R:W465	8.342	5	3	5
123	R:R:Y470	8.14	4	3	3
124	R:R:M487	5.335	4	0	7
125	R:R:W491	9.58	4	3	5
126	R:R:I497	7.35	4	0	5
127	R:R:L500	5.575	4	16	5
128	R:R:L502	2.9825	4	2	7
129	R:R:Y508	4.68333	6	2	8
130	R:R:V511	4.1875	4	2	9
131	R:R:I513	3.2825	4	2	9
132	R:R:F515	6.586	5	2	9
133	R:R:P516	4.48333	6	2	9
134	R:R:M517	3.57333	6	2	8
135	R:R:D518	4.8075	4	0	7
136	R:R:T530	2.2625	4	18	4
137	R:R:L532	3.235	4	19	9
138	R:R:I541	2.325	4	3	4
139	R:R:I542	6.472	5	3	8
140	R:R:C545	4.4025	4	3	6
141	R:R:I549	7.9575	4	0	9
142	R:R:M571	9.1575	4	3	8
143	R:R:I573	6.006	5	9	5
144	R:R:L574	6.112	5	3	9
145	R:R:I575	4.51	6	3	9
146	R:R:F579	6.9725	4	0	8
147	R:R:I585	6.04	4	2	9
148	R:R:K605	5.725	6	2	9
149	R:R:V609	3.0525	4	2	9
150	R:R:Y612	6.676	5	0	7
151	R:R:S616	3.436	5	2	9
152	R:R:C617	2.11	4	2	9
153	R:R:P620	6.21	4	0	9
154	R:R:L622	4.495	4	9	9
155	R:R:Y623	11.116	5	2	9
156	R:R:F626	11.835	4	9	8
157	R:R:F630	8.15	5	2	8
158	R:R:D633	4.18	5	2	8
159	R:R:F634	3.566	5	2	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I80	R:R:I83	16.6277	8.83	Yes	Yes	1	8	7
2	R:R:L153	R:R:L179	13.456	5.54	Yes	Yes	1	9	8
3	R:R:G223	R:R:T222	21.1972	1.82	No	No	0	7	3
4	R:R:T198	R:R:T222	20.844	10.99	No	No	0	5	3
5	R:R:S176	R:R:T198	20.4913	1.6	No	No	0	5	5
6	R:R:I105	R:R:I80	16.4936	13.25	No	Yes	0	8	8
7	R:R:I105	R:R:I130	18.8785	4.42	No	No	0	8	8
8	R:R:I130	R:R:I155	22.8071	2.94	No	Yes	0	8	8
9	R:R:G223	R:R:P224	19.1	4.06	No	Yes	1	7	8
10	R:R:L179	R:R:L202	16.5481	2.77	Yes	Yes	1	8	7
11	R:R:I155	R:R:L181	20.2245	2.85	Yes	Yes	1	8	8
12	R:R:L181	R:R:L204	12.4714	4.15	Yes	Yes	1	8	9
13	R:R:S176	R:R:T200	11.9621	3.2	No	No	0	5	4
14	R:R:T178	R:R:T200	11.1273	3.14	No	No	0	6	4
15	R:R:I135	R:R:I161	11.5513	4.42	Yes	Yes	1	7	7
16	R:R:N184	R:R:N207	11.1807	4.09	Yes	Yes	1	9	9
17	R:R:N207	R:R:T232	35.5503	2.92	Yes	Yes	1	9	9
18	R:R:L202	R:R:L227	23.6653	2.77	Yes	Yes	0	7	8
19	R:R:I245	R:R:P224	14.1571	3.39	Yes	Yes	1	8	8
20	R:R:I229	R:R:T232	49.5798	7.6	Yes	Yes	1	7	9
21	R:R:L227	R:R:L248	27.3325	2.77	Yes	Yes	0	8	9
22	R:R:A250	R:R:I229	29.5631	3.25	Yes	Yes	1	8	7
23	R:R:I229	R:R:L256	29.5755	1.43	Yes	Yes	1	7	8
24	R:R:L256	R:R:L259	14.8634	5.54	Yes	Yes	1	8	6
25	R:R:L259	R:R:P260	11.0027	4.93	Yes	No	0	6	6
26	R:R:L248	R:R:L273	29.4901	4.15	Yes	Yes	1	9	7
27	R:R:A250	R:R:L273	14.831	1.58	Yes	Yes	1	8	7
28	R:R:A250	R:R:S253	14.8975	3.42	Yes	No	1	8	7
29	R:R:L256	R:R:S253	14.8659	3	Yes	No	1	8	7
30	R:R:S253	R:R:T274	29.7549	4.8	No	No	0	7	9
31	R:R:H278	R:R:L273	44.3558	5.14	Yes	Yes	1	9	7
32	R:R:H278	R:R:Y275	70.2624	4.36	Yes	No	0	9	8
33	R:R:K257	R:R:Y275	100	3.58	No	No	0	7	8
34	R:R:H278	R:R:L259	25.8626	12.86	Yes	Yes	1	9	6
35	R:R:T274	R:R:Y275	29.7496	3.75	No	No	0	9	8
36	R:R:I431	R:R:K257	99.9835	1.45	No	No	0	8	7
37	R:R:I431	R:R:N428	99.9717	1.42	No	No	0	8	6
38	R:R:N428	R:R:Y427	99.9656	2.33	No	Yes	0	6	7
39	R:R:C353	R:R:Y427	99.855	2.69	No	Yes	15	9	7
40	R:R:C353	R:R:E354	99.9327	1.52	No	No	0	9	7
41	R:R:E354	R:R:P352	99.9257	1.57	No	Yes	0	7	9
42	R:R:N351	R:R:P352	99.8194	1.63	Yes	Yes	2	8	9
43	R:R:N351	R:R:V511	98.0393	1.48	Yes	Yes	2	8	9
44	R:R:I513	R:R:V511	39.8163	6.14	Yes	Yes	2	9	9
45	R:R:M517	R:R:V511	56.6762	6.09	Yes	Yes	2	8	9
46	R:R:L608	R:R:M517	22.7875	2.83	No	Yes	2	8	8
47	R:R:I585	R:R:L608	22.7365	5.71	Yes	No	2	9	8
48	R:R:F515	R:R:I513	34.2919	2.51	Yes	Yes	2	9	9
49	R:R:F515	R:R:Y411	18.2498	2.06	Yes	Yes	2	9	7
50	R:R:L412	R:R:Y411	18.4355	2.34	Yes	Yes	2	8	7
51	R:R:F515	R:R:M517	34.1922	4.98	Yes	Yes	2	9	8
52	R:R:F515	R:R:T446	22.3486	10.38	Yes	Yes	2	9	8
53	R:R:A373	R:R:G409	15.2318	1.95	Yes	No	0	9	9
54	R:R:G409	R:R:L412	17.2357	1.71	No	Yes	0	9	8
55	R:R:A373	R:R:D405	15.0441	1.54	Yes	Yes	2	9	9
56	R:R:T446	R:R:V447	20.1603	3.17	Yes	No	2	8	8
57	R:R:I497	R:R:V447	39.9358	3.07	Yes	No	0	5	8
58	R:R:E451	R:R:I497	38.5018	16.4	No	Yes	0	9	5
59	R:R:E451	R:R:S494	38.1366	4.31	No	No	0	9	7
60	R:R:F515	R:R:P516	27.885	13	Yes	Yes	2	9	9
61	R:R:P516	R:R:V447	20.1491	3.53	Yes	No	2	9	8
62	R:R:L452	R:R:S494	33.5691	3	Yes	No	0	7	7
63	R:R:L452	R:R:T456	29.8864	4.42	Yes	Yes	3	7	8
64	R:R:I460	R:R:T456	25.7797	3.04	Yes	Yes	3	9	8
65	R:R:I585	R:R:L607	21.4705	1.43	Yes	No	2	9	8
66	R:R:F588	R:R:L607	21.4733	9.74	No	No	0	8	8
67	R:R:F588	R:R:P584	21.4106	1.44	No	No	0	8	9
68	R:R:A583	R:R:P584	21.3337	1.87	No	No	0	8	9
69	R:R:A583	R:R:F579	21.2604	2.77	No	Yes	0	8	8
70	R:R:I542	R:R:I575	13.3118	2.94	Yes	Yes	3	8	9
71	R:R:D578	R:R:F579	13.9837	2.39	No	Yes	0	8	8
72	R:R:I460	R:R:M571	19.138	4.37	Yes	Yes	3	9	8
73	R:R:M571	R:R:T461	17.3851	1.51	Yes	Yes	3	8	8
74	R:R:L462	R:R:T461	14.6095	1.47	No	Yes	3	5	8
75	R:R:I542	R:R:T461	12.81	12.16	Yes	Yes	3	8	8
76	R:R:C545	R:R:T461	14.6089	10.14	Yes	Yes	3	6	8
77	R:R:L462	R:R:W465	13.9148	3.42	No	Yes	3	5	5
78	R:R:C545	R:R:W465	19.827	2.61	Yes	Yes	3	6	5
79	R:R:W465	R:R:Y470	23.6215	15.43	Yes	Yes	3	5	3
80	R:R:H466	R:R:Y470	11.8167	9.8	No	Yes	0	5	3
81	R:R:H473	R:R:Y470	10.129	1.09	No	Yes	0	4	3
82	R:R:I164	R:R:V189	13.3968	3.07	Yes	No	0	7	7
83	R:R:I83	R:R:L86	10.5762	1.43	Yes	Yes	1	7	8
84	R:R:F186	R:R:I161	13.5176	16.33	Yes	Yes	1	8	7
85	R:R:F186	R:R:N207	15.6069	2.42	Yes	Yes	1	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 7FIJ

PDB Summary
PDB	7FIJ
Class	A
SubFamily	Protein
Type	Glycoprotein Hormone
SubType	LH
Species	Homo Sapiens
Ligand	-
Other Ligand(s)	-
Protein Partners	-
PDB Resolution	3.8
Date	2021-09-29
D.O.I.	doi.org/10.1038/s41586-021-03924-2

Net Summary
I_min	1.42
Number of Linked Nodes	538
Number of Links	755
Number of Hubs	159
Number of Links mediated by Hubs	512
Number of Communities	21
Number of Nodes involved in Communities	257
Number of Links involved in Communities	404

Path Summary
Number Of Nodes in MetaPath	86
Number Of Links MetaPath	85
Number of Shortest Paths	1600312
Length Of Smallest Path	3
Average Path Length	29.7775
Length of Longest Path	53
Minimum Path Strength	1.26
Average Path Strength	4.43324
Maximum Path Strength	20.25
Minimum Path Correlation	0.7
Average Path Correlation	0.984078
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.125
Average % Of Corr. Nodes	41.5313
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	57.5482
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • gonad development • reproductive system development • reproductive process • sex differentiation • animal organ development • developmental process involved in reproduction • male gonad development • male sex differentiation • multicellular organism development • development of primary male sexual characteristics • development of primary sexual characteristics • anatomical structure development • reproductive structure development • system development • tube development • seminiferous tubule development • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • cellular response to gonadotropin stimulus • cellular response to luteinizing hormone stimulus • response to endogenous stimulus • response to luteinizing hormone • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • response to gonadotropin • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • spermatogenesis • sexual reproduction • multicellular organismal reproductive process • male gamete generation • gamete generation • regulation of steroid biosynthetic process • regulation of cellular process • regulation of hormone biosynthetic process • regulation of hormone metabolic process • regulation of lipid metabolic process • steroid metabolic process • lipid biosynthetic process • regulation of primary metabolic process • regulation of biological quality • hormone biosynthetic process • steroid biosynthetic process • regulation of biosynthetic process • regulation of steroid hormone biosynthetic process • regulation of biological process • regulation of hormone levels • regulation of steroid metabolic process • biological regulation • primary metabolic process • hormone metabolic process • biosynthetic process • metabolic process • regulation of lipid biosynthetic process • regulation of metabolic process • lipid metabolic process • signaling • hormone-mediated signaling pathway • cell communication • signal transduction • system process • nervous system process • cognition • genitalia development • male genitalia development • G protein-coupled receptor signaling pathway • luteinizing hormone signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • uterus development • female gonad development • female sex differentiation • development of primary female sexual characteristics • ovarian follicle development • phospholipase C-activating G protein-coupled receptor signaling pathway • rhythmic process • ovulation cycle • ovulation cycle process • development of secondary male sexual characteristics • development of secondary sexual characteristics • regulation of inositol phosphate biosynthetic process • positive regulation of biological process • regulation of inositol trisphosphate biosynthetic process • alcohol metabolic process • inositol phosphate metabolic process • positive regulation of phosphate metabolic process • positive regulation of metabolic process • positive regulation of inositol trisphosphate biosynthetic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • phosphate-containing compound metabolic process • polyol biosynthetic process • inositol trisphosphate metabolic process • small molecule metabolic process • phosphorus metabolic process • regulation of carbohydrate metabolic process • positive regulation of cellular process • carbohydrate metabolic process • polyol metabolic process • regulation of alcohol biosynthetic process • positive regulation of phosphorus metabolic process • small molecule biosynthetic process • inositol trisphosphate biosynthetic process • carbohydrate biosynthetic process • positive regulation of inositol phosphate biosynthetic process • organophosphate metabolic process • organophosphate biosynthetic process • inositol phosphate biosynthetic process • alcohol biosynthetic process • regulation of phosphorus metabolic process • regulation of carbohydrate biosynthetic process • positive regulation of carbohydrate metabolic process • positive regulation of small molecule metabolic process • positive regulation of alcohol biosynthetic process • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • intracellular anatomical structure • intracellular membraneless organelle • intracellular organelle • centrosome • microtubule organizing center • cellular anatomical structure • cytoskeleton • centriolar satellite • organelle • membraneless organelle • microtubule cytoskeleton • cell periphery • plasma membrane • membrane
Gene Ontology	Cellular Component	• intracellular anatomical structure • intracellular membraneless organelle • intracellular organelle • centrosome • microtubule organizing center • cellular anatomical structure • cytoskeleton • centriolar satellite • organelle • membraneless organelle • microtubule cytoskeleton • cell periphery • plasma membrane • membrane • membrane-bounded organelle • endosome • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • cytoplasmic vesicle • cytoplasm • vesicle
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P22888
Sequence	>7FIJ_Chain_R D G A L R C P G P T A G L T R L S L A Y L P V K V I P S Q A F R G L N E V I K I E I S Q I D S L E R I E A N A F D N L L N L S E I L I Q N T K N L R Y I E P G A F I N L P R L K Y L S I C N T G I R K F P D V T K V F S S E S N F I L E I C D N L H I T T I P G N A F Q G M N N E S V T L K L Y G N G F E E V Q S H A F N G T T L T S L E L K E N V H L E K M H N G A F R G A T G P K T L D I S S T K L Q A L P S Y G L E S I Q R L I A T S S Y S L K K L P S R E T F V N L L E A T L T Y P S H C C A F R N L P T K E Q N F P K T P R C A P E P D A F N P C E D I M G Y D F L R V L I W L I N I L A I M G N M T V L F V L L T S R Y K L T V P R F L M C N L S F A D F C M G L Y L L L I A S V D S Q T K G Q Y Y N H A I D W Q T G S G C S T A G F F T V F A S E L S V Y T L T V I T L E R W H T I T Y A I H L D Q K L R L R H A I L I M L G G W L F S S L I A M L P L V G V S N Y M K V S I C F P M D V E T T L S Q V Y I L T I L I L N V V A F F I I C A C Y I K I Y F A V R N P E L M A T N K D T K I A K K M A I L I F T D F T C M A P I S F F A I S A A F K V P L I T V T N S K V L L V L F Y P I N S C A N P F L Y A I F T K T F Q R D F F L L L S K F G C C Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6ZFZ	A	Amine	Acetylcholine (muscarinic)	M₁	Homo sapiens	77-LH-28-1	-	-	2.17	2021-10-06	doi.org/10.1016/j.cell.2021.11.001
	5OLH	A	Nucleotide	Adenosine	A_2A	Homo sapiens	Vipadenant	Na	-	2.6	2018-01-17	doi.org/10.1038/s41598-017-18570-w
	5GLH	A	Peptide	Endothelin	ET_B	Homo sapiens	Endothelin-1	-	-	2.8	2016-09-07	doi.org/10.1038/nature19319
	7FIH	A	Protein	Glycoprotein Hormone	LH	Homo sapiens	hCG	Org43553	chim(NtGi1-Gs)/β1/γ2	3.2	2021-09-29	doi.org/10.1038/s41586-021-03924-2
	7FIH (No Gprot)	A	Protein	Glycoprotein Hormone	LH	Homo sapiens	hCG	Org43553		3.2	2021-09-29	doi.org/10.1038/s41586-021-03924-2
	7FIG	A	Protein	Glycoprotein Hormone	LH	Homo sapiens	hCG	-	chim(NtGi1L-Gs)/β1/γ2	3.9	2021-09-29	doi.org/10.1038/s41586-021-03924-2
	7FIG (No Gprot)	A	Protein	Glycoprotein Hormone	LH	Homo sapiens	hCG	-		3.9	2021-09-29	doi.org/10.1038/s41586-021-03924-2
	7FII	A	Protein	Glycoprotein Hormone	LH	Homo sapiens	hCG	-	chim(NtGi1-Gs)/β1/γ2	4.3	2021-09-29	doi.org/10.1038/s41586-021-03924-2
	7FII (No Gprot)	A	Protein	Glycoprotein Hormone	LH	Homo sapiens	hCG	-		4.3	2021-09-29	doi.org/10.1038/s41586-021-03924-2
	7FIJ	A	Protein	Glycoprotein Hormone	LH	Homo sapiens	-	-	-	3.8	2021-09-29	doi.org/10.1038/s41586-021-03924-2

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