Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:P45 5.2775435
2R:R:P47 3.53401
3R:R:L59 4.22437
4R:R:V61 5.218536
5R:R:I64 6.056537
6R:R:P65 6.625436
7R:R:F69 5.25428
8R:R:L72 3.55527
9R:R:E74 7.3025424
10R:R:V75 5.58527
11R:R:I76 9.72523
12R:R:I83 9.92437
13R:R:N92 7.054556
14R:R:F94 5.88529
15R:R:L97 10.8975428
16R:R:L100 5.3529
17R:R:I103 4.9225428
18R:R:L104 8.31425
19R:R:I114 6.59428
20R:R:E115 4.8725405
21R:R:F119 7.67628
22R:R:Y127 5.6175426
23R:R:L128 4.27428
24R:R:N132 5.9225428
25R:R:T133 4.632528
26R:R:G134 3.6975405
27R:R:I135 5.93167627
28R:R:F138 5.49167625
29R:R:P139 6.075429
30R:R:E148 3.2125475
31R:R:F151 4.12667625
32R:R:E154 5.734527
33R:R:C156 4.0775427
34R:R:I164 3.334527
35R:R:F169 4.3626
36R:R:K180 7.18333625
37R:R:L181 5.48167628
38R:R:Y182 15.292526
39R:R:N184 5.70714729
40R:R:F186 8.358528
41R:R:F194 5.835409
42R:R:E203 19.31425
43R:R:L204 4.505429
44R:R:N207 3.6529
45R:R:L210 4.21428
46R:R:M213 5.87406
47R:R:G216 2.0825463
48R:R:F218 3.4725408
49R:R:P224 3.915408
50R:R:D228 11.045429
51R:R:I229 3.018527
52R:R:S230 3.1275429
53R:R:L237 4.2125427
54R:R:P238 4.9225429
55R:R:L242 8.895429
56R:R:I245 8.246528
57R:R:L248 7.855429
58R:R:A250 2.4575428
59R:R:S252 4.3375427
60R:R:K257 4.3175407
61R:R:P260 5.4275426
62R:R:F265 6.272527
63R:R:H278 7.89429
64R:R:D355 7.12833647
65R:R:I356 3.544508
66R:R:M357 9.5975417
67R:R:R363 7.6675449
68R:R:I366 7.02667619
69R:R:W367 6.6825409
70R:R:N377 5.5325419
71R:R:V380 2.7975419
72R:R:L384 5.65516
73R:R:P394 4.1875406
74R:R:R395 8.43833617
75R:R:F396 4.236517
76R:R:M398 8.606517
77R:R:C399 2.174518
78R:R:N400 7.155417
79R:R:L401 7.0225418
80R:R:S402 3.342518
81R:R:D405 8.325419
82R:R:F406 7.3075404
83R:R:M408 3.608518
84R:R:G409 1.8175419
85R:R:Y411 9.316517
86R:R:L412 6.212518
87R:R:D419 7.82549
88R:R:Y426 7.252549
89R:R:Y427 5.73254107
90R:R:W433 11.58649
91R:R:Q434 6.38549
92R:R:G443 3.552519
93R:R:F444 10.27418
94R:R:T446 6.448518
95R:R:V447 3.326518
96R:R:F448 6.988518
97R:R:Y455 6418
98R:R:T456 5.92408
99R:R:L457 8.076519
100R:R:T458 2.41618
101R:R:V459 3.6025414
102R:R:I460 6.6875419
103R:R:T461 6.79333618
104R:R:E463 5.035419
105R:R:R464 9.27571718
106R:R:W465 18.8254125
107R:R:K477 5.555415
108R:R:W491 8.796515
109R:R:I497 7.85415
110R:R:S506 3.484518
111R:R:Y508 14.1825418
112R:R:F515 9.445419
113R:R:P516 10.578519
114R:R:M517 4.186518
115R:R:D518 5.738517
116R:R:V519 4.21406
117R:R:Y527 8.885617
118R:R:I542 9.658518
119R:R:C545 3.22406
120R:R:Y546 10.678519
121R:R:E557 6.945404
122R:R:M571 10.67418
123R:R:L574 7.822519
124R:R:I575 11.1325419
125R:R:T577 5.854519
126R:R:D578 7.47418
127R:R:I585 6.405419
128R:R:L598 3.74147
129R:R:L608 3.9025418
130R:R:Y612 6.75333617
131R:R:N615 9.7825419
132R:R:S616 4.942519
133R:R:N619 8.43714719
134R:R:P620 3.996519
135R:R:L622 5.735419
136R:R:Y623 11.1275419
137R:R:T629 3.045406
138R:R:F630 14.718518
139R:R:D633 2.8975408
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:E115 R:R:R88 13.99213.49YesNo051
2R:R:A93 R:R:I64 16.39764.87NoYes087
3R:R:A91 R:R:E115 15.31396.03NoYes055
4R:R:A91 R:R:N92 13.92573.13NoYes056
5R:R:R88 R:R:Y113 18.618517.49NoNo011
6R:R:A93 R:R:F94 16.98342.77NoYes089
7R:R:I103 R:R:L128 17.24992.85YesYes288
8R:R:I130 R:R:T133 14.17044.56NoYes088
9R:R:R112 R:R:Y113 20.47823.09NoNo051
10R:R:H160 R:R:R112 21.42039.03NoNo035
11R:R:G134 R:R:H160 25.25629.53YesNo053
12R:R:L128 R:R:L153 27.3096.92YesNo289
13R:R:F169 R:R:L153 29.97424.87YesNo269
14R:R:F169 R:R:L179 18.07312.44YesNo068
15R:R:C156 R:R:E154 10.45547.6YesYes277
16R:R:F186 R:R:N184 12.11287.25YesYes289
17R:R:F169 R:R:F194 17.08636.43YesYes069
18R:R:L179 R:R:L202 17.06195.54NoNo087
19R:R:L202 R:R:P224 17.53051.64NoYes078
20R:R:F194 R:R:L199 18.9184.87YesNo098
21R:R:L199 R:R:P224 19.38316.57NoYes088
22R:R:L181 R:R:N207 19.09892.75YesYes289
23R:R:I245 R:R:P224 37.21763.39YesYes088
24R:R:K180 R:R:S201 10.57821.53YesNo055
25R:R:S201 R:R:T226 10.02686.4NoNo054
26R:R:N207 R:R:T232 59.61672.92YesNo299
27R:R:I229 R:R:T232 60.45753.04YesNo279
28R:R:I229 R:R:L237 30.36712.85YesYes277
29R:R:A250 R:R:I229 29.9253.25YesYes287
30R:R:F265 R:R:I245 36.3365.02YesYes278
31R:R:F265 R:R:P260 36.161810.11YesYes276
32R:R:A250 R:R:L273 30.18251.58YesNo087
33R:R:L259 R:R:P260 68.57143.28NoYes266
34R:R:H278 R:R:L273 30.22645.14YesNo097
35R:R:F282 R:R:L259 68.472310.96NoNo286
36R:R:C343 R:R:F282 1004.19NoNo098
37R:R:C279 R:R:C343 99.95797.28NoNo099
38R:R:C279 R:R:P347 99.91551.88NoNo098
39R:R:E346 R:R:P347 99.87283.14NoNo048
40R:R:E346 R:R:P345 99.82971.57NoNo049
41R:R:P276 R:R:P345 99.78643.9NoNo079
42R:R:N351 R:R:P276 68.33116.52NoNo087
43R:R:K510 R:R:P276 31.65045.02NoNo067
44R:R:D518 R:R:K510 31.55062.77YesNo076
45R:R:I356 R:R:I513 12.79614.42YesNo089
46R:R:I356 R:R:S512 67.74.64YesNo089
47R:R:N351 R:R:S512 66.97925.96NoNo989
48R:R:I356 R:R:M357 52.58792.92YesYes087
49R:R:L412 R:R:M357 51.09282.83YesYes187
50R:R:F611 R:R:I585 11.55782.51NoYes089
51R:R:F611 R:R:L607 11.010713.4NoNo088
52R:R:G409 R:R:L412 44.05691.71YesYes198
53R:R:G409 R:R:S616 42.97141.86YesYes199
54R:R:D405 R:R:S616 39.12158.83YesYes199
55R:R:D405 R:R:N619 32.96528.08YesYes199
56R:R:P620 R:R:V380 11.09651.77YesYes199
57R:R:L384 R:R:V380 10.18382.98YesYes169
58R:R:D518 R:R:S506 29.45564.42YesYes178
59R:R:S506 R:R:Y527 28.06336.36YesYes187
60R:R:I497 R:R:Y527 27.62654.84YesYes157
61R:R:E451 R:R:I497 27.665810.93NoYes195
62R:R:E451 R:R:S494 27.66982.87NoNo197
63R:R:S494 R:R:W491 24.30714.94NoYes175
64R:R:N400 R:R:W491 12.38885.65YesYes175
65R:R:L384 R:R:R395 10.12268.5YesYes167
66R:R:R395 R:R:S387 11.11532.64YesNo077
67R:R:D633 R:R:S387 10.26354.42YesNo087
68R:R:D633 R:R:L636 20.6511.36YesNo083
69R:R:K640 R:R:L636 18.77531.41NoNo043
70R:R:N619 R:R:Y623 13.651610.47YesYes199
71R:R:F630 R:R:V383 10.96196.55YesNo087
72R:R:D633 R:R:V383 10.11022.92YesNo087
73R:R:L574 R:R:N619 10.75964.12YesYes199
74R:R:I460 R:R:L401 17.85532.85YesYes198
75R:R:I460 R:R:R464 13.70923.76YesYes198
76R:R:F119 R:R:L128 10.06144.87YesYes288
77R:R:G134 R:R:T133 12.94311.82YesYes058
78R:R:I130 R:R:I155 15.5172.94NoNo088
79R:R:G134 R:R:N158 12.91851.7YesNo059
80R:R:F186 R:R:I161 15.694823.86YesNo287
81R:R:C156 R:R:N184 24.06481.57YesYes279
82R:R:C156 R:R:Y182 11.82334.03YesYes276
83R:R:I161 R:R:N158 13.217814.16NoNo279
84R:R:F186 R:R:L181 10.96552.44YesYes288
85R:R:N184 R:R:N207 41.49544.09YesYes299
86R:R:L237 R:R:P260 32.04846.57YesYes276
87R:R:F282 R:R:H278 31.56927.92NoYes289
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7FIJ
Class A
SubFamily Protein
Type Glycoprotein hormone
SubType LH
Species Homo sapiens
Ligand -
Other Ligand(s) -
Protein Partners -
PDB Resolution 3.8
Date 2021-09-29
D.O.I. 10.1038/s41586-021-03924-2
Net Summary
Imin 1.57
Number of Linked Nodes 530
Number of Links 728
Number of Hubs 139
Number of Links mediated by Hubs 465
Number of Communities 14
Number of Nodes involved in Communities 219
Number of Links involved in Communities 343
Path Summary
Number Of Nodes in MetaPath 88
Number Of Links MetaPath 87
Number of Shortest Paths 792429
Length Of Smallest Path 3
Average Path Length 28.6297
Length of Longest Path 49
Minimum Path Strength 1.385
Average Path Strength 5.21246
Maximum Path Strength 27.83
Minimum Path Correlation 0.7
Average Path Correlation 0.97407
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.7027
Average % Of Corr. Nodes 46.501
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 48.1838
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .


This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
5OLHANucleotideAdenosineA2AHomo sapiensVipadenantNa-2.62018-01-1710.1038/s41598-017-18570-w
5GLHAPeptideEndothelinETBHomo sapiensEndothelin-1--2.82016-09-0710.1038/nature19319
7FIGAProteinGlycoprotein hormoneLHHomo sapienshCG-chim(NtGi1L-Gs)/&β;1/&γ;23.92021-09-2910.1038/s41586-021-03924-2
7FIHAProteinGlycoprotein hormoneLHHomo sapienshCGOrg43553chim(NtGi1-Gs)/&β;1/&γ;23.22021-09-2910.1038/s41586-021-03924-2
7FIIAProteinGlycoprotein hormoneLHHomo sapienshCG-6fuf4.32021-09-2910.1038/s41586-021-03924-2
7FIJAProteinGlycoprotein hormoneLHHomo sapiens---3.82021-09-2910.1038/s41586-021-03924-2
6ZFZAAmineAcetylcholine (muscarinic)M1Homo sapiens77-LH-28-1--2.172021-10-0610.1016/j.cell.2021.11.001




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7FIJ.zip



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