Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1B:B:V40 5.064323
2B:B:R48 3.18487
3B:B:H54 6.85333639
4B:B:K57 16.225439
5B:B:W63 6.298507
6B:B:S74 6.276539
7B:B:D76 10.49439
8B:B:K78 12.585438
9B:B:I80 5.965438
10B:B:W82 8.92857739
11B:B:D83 4.6875488
12B:B:Y85 4.5025484
13B:B:K89 8.032539
14B:B:I93 6.9665187
15B:B:L95 3.65754188
16B:B:W99 6.546559
17B:B:Y105 5.996506
18B:B:D118 6.095409
19B:B:Y124 7.4125186
20B:B:F151 5.866509
21B:B:D163 8.5325199
22B:B:W169 6.6885198
23B:B:F180 6.56597
24B:B:D186 6.5475409
25B:B:M188 3.6325408
26B:B:F199 3.396599
27B:B:S207 5.7825495
28B:B:K209 9.716596
29B:B:L210 3.0425445
30B:B:W211 7.40667698
31B:B:Q220 5.582547
32B:B:F222 7.545448
33B:B:H225 8.792549
34B:B:E226 9.374543
35B:B:I232 5.792548
36B:B:F235 6.615116
37B:B:F241 6.556546
38B:B:T243 8.24548
39B:B:S245 6.9475449
40B:B:D247 13.18449
41B:B:T249 9.5025446
42B:B:R251 9.09548
43B:B:F253 5.975646
44B:B:D254 3.595409
45B:B:A257 2.73407
46B:B:L261 3.5254225
47B:B:M262 5.5425224
48B:B:Y264 5.7465225
49B:B:R283 8.314329
50B:B:L284 3.87405
51B:B:Y289 7.548537
52B:B:D290 6.3225436
53B:B:N293 6.09405
54B:B:N295 10.14436
55B:B:D298 5.25754329
56B:B:R304 7.676535
57B:B:H311 9.37754279
58B:B:R314 10.83538
59B:B:L318 5.116506
60B:B:T321 5.58487
61B:B:D323 7.972587
62B:B:M325 6.916585
63B:B:T329 5.2365278
64B:B:W332 8.735639
65B:B:W339 5.2965279
66B:B:N340 6.79489
67G:G:Y40 8.41754116
68G:G:H44 9.0565116
69G:G:D48 5.015119
70G:G:N59 5.68589
71G:G:F61 6.12429788
72R:R:P38 3.08254363
73R:R:P45 7.056515
74R:R:P47 6.785401
75R:R:L51 5.63754365
76R:R:Y58 14.1425405
77R:R:L59 5.945407
78R:R:I64 4.3025417
79R:R:K77 4.685235
80R:R:Q82 5.645626
81R:R:L86 5.3175418
82R:R:F94 9.115619
83R:R:D95 4.7254286
84R:R:L100 8.11419
85R:R:E102 8.14754237
86R:R:N107 5.948527
87R:R:L111 6.495617
88R:R:R112 7.74245
89R:R:E115 7.37754375
90R:R:F119 6.23333618
91R:R:N121 5.66254287
92R:R:L122 7.885418
93R:R:L125 5.75519
94R:R:Y127 18.39754236
95R:R:L128 5.2075418
96R:R:N132 3.946508
97R:R:T133 8.01418
98R:R:I135 7.808517
99R:R:F138 7.158515
100R:R:F151 8.13714715
101R:R:L153 7.984519
102R:R:E154 4.305477
103R:R:C156 4.905477
104R:R:N158 8.128519
105R:R:H160 8.274243
106R:R:N167 6.09754397
107R:R:F169 8.59616
108R:R:M172 6.314516
109R:R:N173 7.0725414
110R:R:L179 8.175418
111R:R:L181 4.105418
112R:R:Y182 14.4175876
113R:R:N184 9.15833619
114R:R:F186 15.452518
115R:R:F194 10.814519
116R:R:L199 6.2225418
117R:R:L202 5.268517
118R:R:E203 9.86475
119R:R:L204 6.2125419
120R:R:K205 13.4217677
121R:R:E206 10.28674
122R:R:N207 6.925419
123R:R:L210 5.235418
124R:R:F218 5.0475418
125R:R:P224 8.47418
126R:R:L227 7.86418
127R:R:D228 8.58479
128R:R:I229 4.4725417
129R:R:T232 7.775419
130R:R:R247 10.37405
131R:R:K257 7.145417
132R:R:P260 5.0425416
133R:R:F265 8.08667617
134R:R:L273 3.48417
135R:R:Y275 10.55418
136R:R:H278 9.27419
137R:R:F282 7.29418
138R:R:D348 2.69254209
139R:R:F350 7.664208
140R:R:M357 5.1675407
141R:R:Y359 5.9725216
142R:R:L362 5.814218
143R:R:V383 5.40754167
144R:R:R395 6.254167
145R:R:N400 4.5754417
146R:R:M408 2.945428
147R:R:Y411 8.486257
148R:R:D419 8.2154129
149R:R:Q425 6.14124
150R:R:Y426 5.284129
151R:R:Y427 11.744127
152R:R:H429 5.90754126
153R:R:F448 5.195408
154R:R:T458 3.46254268
155R:R:I460 4.484319
156R:R:T461 5.6925268
157R:R:R464 5.3454318
158R:R:W465 5.7225405
159R:R:I472 5.5825405
160R:R:Q476 8.4654435
161R:R:W491 7.45405
162R:R:Y508 6.5875408
163R:R:M509 6.0325406
164R:R:K510 6.6165206
165R:R:Q525 2.754506
166R:R:Y527 7.224447
167R:R:F539 4.655408
168R:R:I542 7.12254268
169R:R:C545 3.3154266
170R:R:Y546 4.8465269
171R:R:K563 7.073336145
172R:R:I599 7.55754458
173R:R:F611 3.872508
174R:R:S616 2.9275409
175R:R:Y623 4.854509
176R:R:F630 4.796168
177R:R:L637 3.744307
178A:A:T40 4.9025406
179A:A:L44 4.488559
180A:A:N50 5.23754139
181A:A:S51 3.3954469
182A:A:K53 3.8745469
183A:A:I207 4.7325459
184A:A:E209 6.115459
185A:A:F212 5.20254179
186A:A:V214 4.6545175
187A:A:V217 3.354176
188A:A:F219 5.732867178
189A:A:M221 3.5225408
190A:A:F222 6.7275456
191A:A:W234 7.198559
192A:A:F238 5.42659
193A:A:I244 3.62458
194A:A:S251 6.774139
195A:A:Y253 4.896509
196A:A:R265 5.85139
197A:A:D272 6.575459
198A:A:F273 5.2025469
199A:A:I276 2.754558
200A:A:W277 10.085466
201A:A:W281 8.45167635
202A:A:L289 4.2775409
203A:A:F290 5.348509
204A:A:N292 5.75254139
205A:A:K293 10.7125139
206A:A:Q294 8.6845476
207A:A:L296 5.63254137
208A:A:L297 4.185409
209A:A:F312 7.6425468
210A:A:F315 7.312506
211A:A:Y318 10.43467
212A:A:P321 6.3075464
213A:A:D331 7.58754484
214A:A:V334 4.3325404
215A:A:K338 11.38254475
216A:A:F340 11.5225466
217A:A:R342 5.99465
218A:A:F345 3.7575468
219A:A:I348 4.272565
220A:A:S349 4.0825468
221A:A:C359 3.3875466
222A:A:Y360 5.716148
223A:A:F376 6.646179
224A:A:R385 12.81754146
225A:A:L388 4.2375408
226A:A:L394 9.93754147
227L:L:C31 4.00754150
228L:L:N39 8.455100
229L:L:F42 11.124100
230L:L:I49 4.90254100
231L:L:Y61 6.75714720
232L:L:P62 13.3725420
233L:L:T63 4.20667620
234L:L:P64 4.515420
235L:L:K68 6.235420
236L:L:M71 5.964520
237L:L:L72 5.554240
238L:L:T78 4.3375420
239L:L:F98 7.22254100
240L:L:V100 6.69254100
241L:L:N102 7.68754100
242L:L:Y112 12.2065230
243L:L:H114 4.3875470
244L:L:K115 7.24333670
245M:M:R26 3.43754150
246M:M:L36 10.3333620
247M:M:E41 5.785420
248M:M:T51 10.6375420
249M:M:I53 5.45833620
250M:M:C54 3.4400
251M:M:Y57 7.493336150
252M:M:C58 5.214150
253M:M:V64 7.3854100
254M:M:L65 9.23754100
255M:M:L72 4.2185400
256M:M:L89 5.09400
257M:M:Y102 10.1467620
258M:M:R114 8.31286770
259M:M:R115 9.296570
260M:M:T118 3.905400
261M:M:D119 5.9325420
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:Q6 B:B:Q9 32.35081.28NoNo013
2B:B:E10 B:B:Q6 29.862410.19NoNo081
3B:B:E10 G:G:V16 27.37391.43NoNo087
4B:B:L7 G:G:V16 24.88548.94NoNo087
5B:B:L14 B:B:Q17 44.79291.33NoNo084
6B:B:Q13 B:B:Q17 42.30451.28NoNo014
7B:B:Q13 B:B:Q9 39.81611.28NoNo013
8B:B:L14 G:G:K20 47.28135.64NoNo086
9B:B:I18 G:G:A23 52.2583.25NoNo078
10G:G:A23 G:G:K20 49.76963.21NoNo086
11B:B:I18 B:B:R22 64.69967.52NoNo076
12B:B:C25 B:B:Q259 69.67621.53NoNo036
13B:B:C25 B:B:R22 67.18791.39NoNo036
14B:B:A257 B:B:Q259 77.14074.55YesNo076
15B:B:A257 B:B:L261 99.53471.58YesYes075
16B:B:L261 B:B:M262 51.01172.83YesYes2254
17B:B:I37 B:B:R283 12.44043.76NoYes029
18B:B:D298 B:B:R283 19.90437.15YesYes3299
19B:B:D298 B:B:K301 1005.53YesNo095
20B:B:D303 B:B:K301 1004.15NoNo025
21B:B:D303 B:B:R304 1002.38NoYes025
22B:B:R304 B:B:W297 69.640311YesNo058
23B:B:W297 B:B:Y264 1007.72NoYes085
24B:B:L252 B:B:Y264 52.25492.34NoYes2275
25B:B:L252 B:B:L261 51.01095.54NoYes2275
26B:B:M262 B:B:Y264 57.231511.97YesYes2245
27B:B:D298 B:B:L284 92.0245.43YesYes095
28B:B:K337 B:B:T50 14.92294.5NoNo063
29B:B:W297 B:B:Y289 1005.79NoYes087
30B:B:C271 B:B:Y289 1002.69NoYes357
31B:B:C271 B:B:D290 1003.11NoYes356
32B:B:R314 B:B:W332 13.791518.99YesYes389
33B:B:K57 B:B:W332 15.0512.76YesYes399
34B:B:H54 B:B:W82 1006.35YesYes399
35B:B:L70 B:B:W82 1004.56NoYes059
36B:B:L70 B:B:W63 1007.97NoYes057
37B:B:T321 B:B:W63 1009.7YesYes077
38B:B:S67 B:B:T321 92.03253.2NoYes857
39B:B:M325 B:B:S67 89.54826.13YesNo855
40B:B:M325 G:G:F61 54.68317.46YesYes858
41B:B:D323 B:B:T321 94.51795.78YesYes877
42B:B:D323 B:B:M325 89.550115.25YesYes875
43B:B:M325 G:G:P60 29.82783.35YesNo859
44G:G:N59 G:G:P60 24.85656.52YesNo899
45G:G:F61 G:G:N59 24.86144.83YesYes889
46B:B:L51 B:B:W82 12.435918.22NoYes099
47B:B:K78 B:B:L55 1009.87YesNo086
48A:A:L30 B:B:L55 1009.69NoNo066
49A:A:K34 B:B:L55 10018.33NoNo056
50B:B:C103 B:B:C114 19.89473.64NoNo088
51B:B:C114 B:B:L79 24.86843.17NoNo087
52B:B:L79 B:B:L95 54.70962.77NoYes078
53B:B:L95 B:B:S97 1003YesNo088
54B:B:D118 B:B:S97 1005.89YesNo098
55A:A:I207 B:B:D118 1005.6YesYes099
56A:A:I207 B:B:W99 84.55023.52YesYes599
57A:A:F238 B:B:W99 44.79838.02YesYes599
58A:A:N279 A:A:W281 1003.39NoYes085
59A:A:W281 B:B:D290 1006.7YesYes356
60A:A:I207 B:B:L117 42.28395.71YesNo099
61A:A:F238 B:B:L117 43.52712.44YesNo099
62B:B:H62 B:B:R150 27.47764.51NoNo066
63B:B:C148 B:B:R150 85.82724.18NoNo066
64B:B:C148 B:B:L190 89.5324.76NoNo065
65B:B:L190 B:B:S160 90.77434.5NoNo056
66B:B:S147 B:B:S160 93.25984.89NoNo096
67B:B:M188 B:B:S147 94.50273.07YesNo089
68B:B:M188 B:B:Y145 1002.39YesNo088
69A:A:K233 B:B:Y145 10014.33NoNo098
70A:A:E230 A:A:K233 10014.85NoNo099
71A:A:E230 A:A:R232 1004.65NoNo098
72A:A:R232 A:A:W281 1005NoYes085
73B:B:H62 B:B:Y105 24.9954.36NoYes066
74B:B:G319 B:B:L318 69.69073.42NoYes056
75B:B:L318 B:B:T329 42.36477.37YesYes068
76B:B:T329 B:B:W339 15.02562.43YesYes2789
77B:B:T65 B:B:Y105 19.95746.24NoYes016
78B:B:M325 B:B:Y85 89.64682.39YesYes854
79B:B:D83 B:B:L69 14.91435.43YesNo085
80B:B:D83 B:B:Y85 74.56924.6YesYes884
81B:B:I93 B:B:L79 24.86832.85YesNo077
82B:B:I93 B:B:Y124 24.86829.67YesYes1876
83B:B:L95 B:B:Y124 59.68325.86YesYes1886
84B:B:K89 B:B:W82 10017.4YesYes399
85B:B:D83 B:B:T86 54.68515.78YesNo086
86B:B:N88 B:B:T86 49.71388.77NoNo076
87B:B:H91 B:B:I93 29.84186.63NoYes1857
88B:B:H91 B:B:V133 14.92096.92NoNo1854
89B:B:V133 B:B:Y124 19.89455.05NoYes1846
90B:B:H91 B:B:N132 29.84182.55NoNo053
91A:A:E209 A:A:F222 48.49228.16YesYes596
92A:A:F222 A:A:L44 1002.44YesYes569
93A:A:I244 A:A:L44 1002.85YesYes589
94A:A:I244 A:A:L282 1005.71YesNo089
95A:A:L282 A:A:N279 1004.12NoNo098
96B:B:A106 B:B:F151 16.21575.55NoYes069
97B:B:A106 B:B:P107 17.46291.87NoNo066
98B:B:P107 B:B:T65 18.71021.75NoNo061
99B:B:L192 B:B:R150 57.28443.64NoNo056
100B:B:L152 B:B:L192 23.6644.15NoNo035
101B:B:L152 B:B:Q156 18.68256.65NoNo035
102B:B:F151 B:B:I123 11.22642.51YesNo096
103B:B:D118 B:B:I120 19.89487YesNo096
104A:A:R228 B:B:D163 26.12387.15NoYes099
105A:A:R228 B:B:T164 27.36816.47NoNo096
106B:B:D186 B:B:T164 32.34834.34YesNo096
107A:A:K233 B:B:D186 36.068413.83NoYes099
108B:B:A140 B:B:I120 14.92114.87NoNo056
109B:B:D163 B:B:S161 11.19697.36YesNo1999
110B:B:N132 B:B:R134 14.920912.05NoNo033
111B:B:F199 B:B:L192 32.38132.44YesNo095
112B:B:F199 B:B:W211 17.43645.01YesYes998
113B:B:I273 B:B:Y289 59.72217.25NoYes067
114B:B:G244 B:B:I273 58.4793.53NoNo056
115B:B:G244 B:B:T243 48.53913.64NoYes058
116B:B:F253 B:B:T243 22.40152.59YesYes468
117B:B:I232 B:B:T243 14.93379.12YesYes488
118B:B:G238 B:B:N239 12.43721.7NoNo072
119B:B:N237 B:B:N239 14.92469.54NoNo052
120B:B:F235 B:B:N237 17.41152.42YesNo1165
121B:B:F235 B:B:G282 47.25954.52YesNo1169
122B:B:G282 B:B:S279 77.10753.71NoNo099
123B:B:L284 B:B:S279 79.59463YesNo059
124B:B:F222 B:B:F253 12.449311.79YesYes486
125B:B:G282 B:B:P236 27.36084.06NoNo1197
126B:B:F235 G:G:Y40 24.87354.13YesYes1166
127B:B:P236 G:G:Y40 24.87354.17NoYes1176
128B:B:A257 B:B:D254 12.44293.09YesYes079
129G:G:H44 G:G:Y40 44.77283.27YesYes1166
130G:G:D48 G:G:H44 24.87388.82YesYes1196
131B:B:N295 B:B:Y289 72.08313.96YesYes367
132B:B:N295 B:B:R304 69.597218.08YesYes365
133A:A:Q236 A:A:W281 14.928218.62NoYes385
134B:B:L7 G:G:R13 17.41991.21NoNo086
135G:G:I9 G:G:R13 12.44296.26NoNo026
136G:G:N59 G:G:V54 39.77441.48YesNo096
137G:G:P55 G:G:V54 29.83081.77NoNo056
138G:G:E58 G:G:P55 19.887214.15NoNo055
139A:A:I244 A:A:V287 1003.07YesNo085
140A:A:L289 A:A:V287 1002.98YesNo095
141A:A:C359 A:A:L289 1003.17YesYes069
142A:A:C359 A:A:L346 1003.17YesNo663
143A:A:L346 A:A:R342 1006.07NoYes635
144A:A:D343 A:A:R342 1005.96NoYes635
145A:A:D343 A:A:Y318 10013.79NoYes637
146A:A:R336 A:A:Y318 1003.09NoYes057
147A:A:F315 A:A:R336 1005.34YesNo065
148A:A:F315 A:A:I308 1008.79YesNo067
149A:A:I308 A:A:Y253 1004.84NoYes079
150A:A:K300 A:A:Y253 10010.75NoYes099
151A:A:K300 A:A:S251 1004.59NoYes099
152A:A:K293 A:A:S251 1007.65YesYes1399
153A:A:K293 A:A:N292 1005.6YesYes1399
154A:A:N292 A:A:T364 1008.77YesNo1399
155A:A:F290 A:A:T364 10012.97YesNo099
156A:A:F290 A:A:I288 1005.02YesNo099
157A:A:D378 A:A:I288 1002.8NoNo1479
158A:A:D378 A:A:Y360 1009.2NoYes1478
159A:A:Y358 A:A:Y360 1003.97NoYes1448
160A:A:Y358 R:R:K563 1004.78NoYes1445
161A:A:L394 R:R:K563 1007.05YesYes1475
162A:A:L394 R:R:I567 1009.99YesNo077
163R:R:I567 R:R:M571 1004.37NoNo078
164R:R:M571 R:R:Y546 1005.99NoYes089
165R:R:L574 R:R:Y546 1009.38NoYes099
166R:R:L574 R:R:Y623 1003.52NoYes099
167R:R:R464 R:R:Y623 1003.09YesYes089
168R:R:I460 R:R:R464 1005.01YesYes3198
169R:R:I460 R:R:T456 1003.04YesNo098
170R:R:L452 R:R:T456 1002.95NoNo078
171R:R:L452 R:R:W491 10010.25NoYes075
172R:R:F448 R:R:W491 10010.02YesYes085
173R:R:A498 R:R:F448 1004.16NoYes098
174R:R:A498 R:R:F444 1005.55NoNo098
175R:R:F444 R:R:L502 1006.09NoNo087
176R:R:L502 R:R:Y508 1002.34NoYes078
177R:R:M509 R:R:Y508 1007.18YesYes068
178R:R:M509 R:R:Q434 1002.72YesNo069
179R:R:N351 R:R:Q434 1003.96NoNo089
180R:R:K510 R:R:N351 1004.2YesNo2068
181R:R:K510 R:R:V511 1003.04YesNo2069
182R:R:I513 R:R:V511 1004.61NoNo099
183R:R:I356 R:R:I513 1002.94NoNo089
184R:R:D355 R:R:I356 1005.6NoNo1278
185R:R:D355 R:R:Y426 1005.75NoYes1279
186R:R:C280 R:R:Y426 1005.38NoYes1299
187R:R:C280 R:R:P347 1001.88NoNo098
188R:R:E346 R:R:P347 1001.57NoNo048
189R:R:E346 R:R:P345 1001.57NoNo049
190R:R:C279 R:R:P345 1001.88NoNo099
191R:R:C279 R:R:L273 1004.76NoYes097
192R:R:F282 R:R:L273 1002.44YesYes187
193R:R:F265 R:R:F282 1006.43YesYes178
194R:R:F265 R:R:L248 1004.87YesNo179
195R:R:L227 R:R:L248 1005.54YesNo189
196R:R:L202 R:R:L227 1002.77YesYes178
197R:R:F194 R:R:L202 71.40672.44YesYes197
198R:R:F169 R:R:F194 35.383125.72YesYes169
199R:R:F169 R:R:L153 23.05352.44YesYes169
200R:R:L128 R:R:L153 22.51684.15YesYes189
201R:R:F119 R:R:L128 21.55138.53YesYes188
202R:R:F119 R:R:F94 14.50047.5YesYes189
203A:A:C359 A:A:P361 1003.77YesNo664
204A:A:P361 A:A:R342 1005.76NoYes645
205A:A:F340 A:A:Y318 10016.5YesYes667
206A:A:F315 A:A:F340 10015YesYes066
207A:A:F312 A:A:F340 1006.43YesYes686
208A:A:F312 A:A:I308 1006.28YesNo087
209A:A:R385 A:A:Y358 10015.43YesNo1464
210A:A:L394 A:A:R385 10015.79YesYes1476
211A:A:L388 A:A:L394 1006.92YesYes087
212A:A:L388 A:A:L393 1002.77YesNo089
213A:A:L393 R:R:K570 1002.82NoNo099
214R:R:K570 R:R:L574 10011.28NoNo099
215R:R:N619 R:R:Y623 1005.81NoYes099
216R:R:L401 R:R:N619 1008.24NoNo089
217R:R:L401 R:R:T456 1004.42NoNo088
218R:R:F194 R:R:L179 35.059.74YesYes198
219R:R:L153 R:R:L179 23.0164.15YesYes198
220R:R:L202 R:R:L204 1009.69YesYes179
221R:R:L181 R:R:L204 1004.15YesYes189
222R:R:I155 R:R:L181 1005.71NoYes188
223R:R:I155 R:R:N158 1004.25NoYes189
224R:R:I161 R:R:N158 10011.33NoYes179
225R:R:I135 R:R:I161 1002.94YesNo177
226R:R:I135 R:R:L111 1005.71YesYes177
227R:R:L111 R:R:T108 10010.32YesNo178
228R:R:N132 R:R:T108 1002.92YesNo088
229R:R:N107 R:R:N132 1002.72YesYes078
230R:R:N107 R:R:Q82 80.30939.24YesYes276
231L:L:T70 R:R:Q82 42.838212.76NoYes206
232L:L:T70 R:R:D84 37.48024.34NoNo207
233R:R:D84 R:R:S85 34.81822.94NoNo075
234R:R:K62 R:R:S85 32.13997.65NoNo045
235R:R:L181 R:R:N184 1004.12YesYes189
236R:R:N158 R:R:N184 10016.35YesYes199
237R:R:L204 R:R:N207 1008.24YesYes199
238R:R:N184 R:R:N207 1004.09YesYes199
239R:R:F186 R:R:N184 10024.17YesYes189
240R:R:F186 R:R:I161 10015.07YesNo187
241R:R:I135 R:R:T133 1009.12YesYes178
242R:R:T108 R:R:T133 10010.99NoYes188
243R:R:K62 R:R:R43 26.78343.71NoNo046
244R:R:R43 R:R:V63 24.10517.85NoNo064
245M:M:D119 R:R:N107 1006.73YesYes207
246L:L:T78 M:M:D119 1004.34YesYes200
247L:L:E80 L:L:T78 1004.23NoYes200
248L:L:E80 M:M:P123 1003.14NoNo000
249M:M:G122 M:M:P123 1004.06NoNo000
250L:L:T110 M:M:G122 1001.82NoNo000
251L:L:T110 R:R:E102 48.1995.64NoYes2307
252R:R:E102 R:R:K77 18.74456.75YesYes2375
253L:L:T110 L:L:Y112 1004.99NoYes2300
254L:L:Y112 R:R:K77 18.7472.39YesYes2305
255R:R:K77 R:R:R53 10.71362.48YesNo052
256L:L:V85 L:L:Y112 1005.05NoYes000
257L:L:H107 L:L:V85 1004.15NoNo000
258R:R:Q82 R:R:Y58 16.06613.38YesYes065
259R:R:R88 R:R:V63 21.426817NoNo014
260R:R:E90 R:R:R88 18.74852.33NoNo061
261R:R:F151 R:R:L153 23.024820.7YesYes159
262R:R:F151 R:R:N173 39.72014.83YesYes154
263R:R:E175 R:R:N173 37.5779.2NoYes154
264R:R:E175 R:R:S147 36.50382.87NoNo055
265R:R:P123 R:R:S147 35.43031.78NoNo045
266R:R:N121 R:R:P123 30.06274.89YesNo074
267R:R:F169 R:R:M172 11.79182.49YesYes166
268R:R:F151 R:R:M172 11.52869.95YesYes156
269R:R:L179 R:R:V177 11.76982.98YesNo183
270R:R:F151 R:R:V177 11.50437.87YesNo153
271R:R:I76 R:R:K77 10.71328.72NoYes035
272R:R:K77 R:R:S101 10.71323.06YesNo055
273R:R:N107 R:R:Q106 66.92522.64YesNo077
274R:R:L104 R:R:Q106 16.062411.98NoNo057
275R:R:E115 R:R:E90 13.39185.07YesNo056
276R:R:I120 R:R:N121 23.62142.83NoYes2857
277R:R:E102 R:R:Y127 26.77773.37YesYes2376
278L:L:Y112 R:R:Y127 26.782731.77YesYes2306
279R:R:L104 R:R:S129 10.70957.51NoNo057
280M:M:G121 R:R:Q106 48.18563.29NoNo007
281L:L:M71 R:R:N107 45.49988.41YesYes207
282L:L:L72 R:R:N132 24.10445.49YesYes008
283R:R:I120 R:R:K143 22.54887.27NoNo054
284R:R:K126 R:R:Y127 42.848419.11NoYes056
285R:R:E148 R:R:K126 37.492410.8NoNo055
286R:R:D140 R:R:K143 19.32794.15NoNo034
287R:R:D140 R:R:T142 18.25427.23NoNo034
288L:L:Y89 R:R:E148 26.78033.37NoNo3805
289L:L:E101 L:L:Y89 21.42437.86NoNo000
290L:L:E101 M:M:Q66 16.068216.57NoNo000
291L:L:H114 M:M:G121 45.50844.77YesNo000
292L:L:H114 L:L:K115 26.77642.62YesYes700
293M:M:D119 M:M:T118 1004.34YesYes000
294M:M:C120 M:M:T118 32.15163.38NoYes000
295L:L:K115 M:M:C120 26.79663.23YesNo000
296L:L:K115 R:R:Y182 42.8382.39YesYes706
297M:M:T117 M:M:T118 1003.14NoYes000
298M:M:R114 M:M:T117 1007.76YesNo000
299M:M:R114 R:R:Y182 21.42520.58YesYes706
300R:R:G171 R:R:T142 17.18051.82NoNo044
301R:R:G171 R:R:Q170 16.10681.64NoNo043
302R:R:N167 R:R:Q170 12.88559.24YesNo3973
303R:R:E203 R:R:Y182 48.19510.1YesYes756
304R:R:E203 R:R:K180 53.55182.7YesNo055
305R:R:K180 R:R:T178 42.84153NoNo056
306R:R:T178 R:R:T200 32.13119.42NoNo064
307R:R:S176 R:R:T200 21.42086.4NoNo054
308M:M:R114 R:R:K205 34.81339.9YesYes707
309R:R:E203 R:R:K205 16.06817.55YesYes757
310R:R:S176 R:R:T198 10.71043.2NoNo055
311L:L:H107 L:L:K87 10022.27NoNo000
312L:L:A105 L:L:K87 1001.61NoNo000
313L:L:A105 L:L:T104 1001.68NoNo000
314L:L:N90 L:L:T104 1004.39NoNo000
315L:L:N90 L:L:V92 1005.91NoNo1000
316L:L:V100 L:L:V92 99.08324.81YesNo1000
317L:L:F98 L:L:V100 45.52537.87YesYes1000
318L:L:F98 M:M:V68 34.8166.55YesNo000
319M:M:L69 M:M:V68 32.13794.47NoNo000
320M:M:L69 M:M:P70 29.45983.28NoNo000
321M:M:P70 R:R:R247 26.781712.97NoYes005
322R:R:D228 R:R:K205 16.06978.3YesYes797
323L:L:S116 M:M:R114 40.17092.64NoYes700
324R:R:Q246 R:R:R247 13.39118.69NoYes065
325R:R:D228 R:R:S230 10.7142.94YesNo099
326L:L:S116 M:M:L112 37.494612.01NoNo000
327M:M:L112 M:M:P73 34.81656.57NoNo000
328M:M:L72 M:M:P73 32.13844.93YesNo000
329M:M:L72 R:R:Y331 13.39127.03YesNo4001
330R:R:D330 R:R:Y331 10.7131.15NoNo041
331A:A:A14 A:A:E15 14.91433.02NoNo015
332A:A:A14 A:A:K17 19.88573.21NoNo013
333A:A:K17 A:A:L12 24.8571.41NoNo032
334A:A:L12 A:A:V20 34.79981.49NoNo023
335A:A:S23 A:A:V20 39.77113.23NoNo073
336A:A:S23 B:B:N88 44.74251.49NoNo077
337A:A:R42 A:A:T40 13.68732.59NoYes096
338A:A:F222 A:A:R42 1004.28YesNo069
339A:A:R42 A:A:Y37 10010.29NoNo093
340A:A:R231 A:A:W234 14.91585NoYes599
341A:A:D272 A:A:F246 11.1717.17YesNo599
342A:A:F246 A:A:I276 12.41692.51NoYes598
343A:A:F246 A:A:L289 24.82056.09NoYes099
344A:A:F273 A:A:I348 39.86656.28YesYes695
345A:A:F273 A:A:L289 21.18024.87YesYes099
346A:A:I348 A:A:K274 19.93364.36YesNo055
347A:A:A351 A:A:S352 12.45861.71NoNo044
348A:A:A351 A:A:K274 14.95031.61NoNo045
349L:L:V77 M:M:T118 83.02254.76NoYes000
350L:L:V77 M:M:Y79 80.344515.14NoNo000
351M:M:C54 M:M:Y79 72.31052.69YesNo000
352M:M:C108 M:M:C54 58.92027.28NoYes000
353M:M:C108 M:M:P31 53.56437.53NoNo000
354M:M:P31 M:M:R30 50.88624.32NoNo000
355M:M:K22 M:M:R30 45.534.95NoNo000
356M:M:K22 M:M:P27 42.85183.35NoNo000
357M:M:P27 M:M:Y57 40.17372.78NoYes000
358M:M:R28 M:M:Y57 13.391513.38NoYes1500
359M:M:R26 M:M:Y57 10.71327.2YesYes1500
360L:L:V100 M:M:L65 40.16964.47YesYes1000
361M:M:L65 M:M:V64 37.49344.47YesYes1000
362L:L:Q51 M:M:V64 10011.46NoYes000
363L:L:M53 L:L:Q51 96.40755.44NoNo000
364L:L:M53 L:L:Q37 32.1365.44NoNo000
365L:L:Q37 L:L:T35 16.0684.25NoNo000
366L:L:N102 L:L:N90 1008.17YesNo1000
367L:L:I49 L:L:N102 93.72752.83YesYes1000
368L:L:I49 L:L:N39 45.52489.91YesYes1000
369L:L:N39 M:M:V64 37.49214.43YesYes1000
370L:L:F42 L:L:I49 40.16943.77YesYes1000
371L:L:F42 M:M:V64 37.49119.18YesYes1000
372L:L:G54 L:L:M53 56.23791.75NoNo000
373L:L:C84 L:L:G54 48.20393.92NoNo000
374L:L:V100 L:L:V94 10.71299.62YesNo000
375L:L:C106 L:L:C84 32.1363.64NoNo000
376L:L:C106 L:L:C52 24.1025.46NoNo000
377L:L:T78 L:L:Y61 1002.5YesYes200
378L:L:Y61 M:M:I53 85.69993.63YesYes200
379M:M:A34 M:M:I53 16.06983.25NoYes000
380M:M:A34 M:M:I32 13.39153.25NoNo000
381M:M:A55 M:M:I32 10.71321.62NoNo000
382L:L:H114 L:L:S81 10.71752.79YesNo700
383L:L:M71 L:L:T63 10.71413.01YesYes200
384L:L:Y61 M:M:L36 69.63114.69YesYes200
385M:M:L36 M:M:Y102 61.59711.72YesYes200
386M:M:I53 M:M:Y102 61.59772.42YesYes200
387L:L:K68 L:L:M71 32.12464.32YesYes200
388L:L:K68 M:M:E41 26.78752.7YesYes200
389L:L:L65 M:M:E41 16.07265.3NoYes200
390L:L:L65 M:M:E39 13.393919.88NoNo000
391M:M:L72 M:M:Q74 10.7132.66YesNo000
392M:M:C58 M:M:R28 10.71322.79YesNo1500
393M:M:C46 M:M:E39 10.715112.15NoNo000
394M:M:V38 M:M:Y102 1003.79NoYes000
395M:M:V100 M:M:V38 1008.02NoNo000
396M:M:K40 M:M:V100 21.42573.04NoNo000
397M:M:K40 M:M:N97 16.06939.79NoNo000
398M:M:L89 M:M:V100 74.9897.45YesNo000
399M:M:C92 M:M:L89 26.78216.35NoYes000
400M:M:C43 M:M:C92 21.42577.28NoNo000
401M:M:C43 M:M:P93 10.71293.77NoNo000
402M:M:L89 M:M:P90 26.78213.28YesNo000
403M:M:I47 M:M:P90 16.06933.39NoNo000
404M:M:V104 M:M:Y102 10.71293.79NoYes000
405M:M:L89 M:M:P98 16.06933.28YesNo000
406M:M:P98 M:M:R94 10.71297.21NoNo000
407M:M:N97 M:M:V99 10.71291.48NoNo000
408M:M:I47 M:M:V49 10.71291.54NoNo000
409B:B:G319 B:B:W63 72.17572.81NoYes057
410B:B:H54 B:B:K78 1009.17YesYes398
411A:A:L30 B:B:K89 1002.82NoYes069
412A:A:K34 A:A:Y37 1009.55NoNo3353
413A:A:F222 B:B:W99 44.775412.03YesYes569
414A:A:E209 A:A:I207 42.27274.1YesYes599
415A:A:F238 A:A:L44 94.34028.53YesYes599
416A:A:Q236 B:B:W332 13.68513.29NoYes389
417B:B:H311 B:B:T329 19.88668.21YesYes2798
418A:A:W281 B:B:R314 16.1695YesYes358
419A:A:F273 A:A:S349 21.09332.64YesYes698
420A:A:C359 A:A:S349 27.29693.44YesYes668
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:E32 R:R:P33 3.14 35 No No 3 4 1 1
M:M:D131 R:R:E32 20.79 35 No No 0 3 0 1
M:M:D131 R:R:P33 6.44 35 No No 0 4 0 1
R:R:K77 R:R:R53 2.48 23 Yes No 5 2 1 1
L:L:S109 R:R:R53 7.91 0 No No 0 2 0 1
R:R:A57 R:R:Y58 2.67 0 No Yes 4 5 1 1
M:M:K124 R:R:A57 3.21 2 No No 0 4 0 1
R:R:Q82 R:R:Y58 3.38 2 Yes Yes 6 5 1 1
L:L:R66 R:R:Y58 11.32 2 No Yes 0 5 0 1
M:M:H126 R:R:Y58 39.2 0 No Yes 0 5 0 1
R:R:I76 R:R:K77 8.72 0 No Yes 3 5 2 1
R:R:K77 R:R:S101 3.06 23 Yes No 5 5 1 2
R:R:E102 R:R:K77 6.75 23 Yes Yes 7 5 1 1
L:L:Y112 R:R:K77 2.39 23 Yes Yes 0 5 0 1
R:R:E79 R:R:S81 7.19 0 No No 5 6 2 1
R:R:E79 R:R:L104 15.9 0 No No 5 5 2 2
R:R:Q82 R:R:S81 2.89 2 Yes No 6 6 1 1
M:M:K124 R:R:S81 10.71 2 No No 0 6 0 1
R:R:N107 R:R:Q82 9.24 2 Yes Yes 7 6 1 1
L:L:S67 R:R:Q82 2.89 2 No Yes 0 6 0 1
L:L:T70 R:R:Q82 12.76 2 No Yes 0 6 0 1
M:M:K124 R:R:Q82 2.71 2 No Yes 0 6 0 1
R:R:D84 R:R:S85 2.94 2 No No 7 5 1 2
L:L:R66 R:R:D84 17.87 2 No No 0 7 0 1
L:L:T70 R:R:D84 4.34 2 No No 0 7 0 1
R:R:E102 R:R:Y127 3.37 23 Yes Yes 7 6 1 1
L:L:T110 R:R:E102 5.64 23 No Yes 0 7 0 1
L:L:Y112 R:R:E102 16.83 23 Yes Yes 0 7 0 1
R:R:L104 R:R:Q106 11.98 0 No No 5 7 2 1
R:R:L104 R:R:S129 7.51 0 No No 5 7 2 2
R:R:N107 R:R:Q106 2.64 2 Yes No 7 7 1 1
M:M:G121 R:R:Q106 3.29 0 No No 0 7 0 1
R:R:N107 R:R:N132 2.72 2 Yes Yes 7 8 1 1
L:L:M71 R:R:N107 8.41 2 Yes Yes 0 7 0 1
M:M:D119 R:R:N107 6.73 2 Yes Yes 0 7 0 1
R:R:N132 R:R:T108 2.92 0 Yes No 8 8 1 2
R:R:K109 R:R:N110 6.99 0 No No 6 5 1 2
L:L:L72 R:R:K109 5.64 24 Yes No 0 6 0 1
R:R:G134 R:R:R112 4.5 24 No Yes 5 5 2 1
R:R:R112 R:R:R136 4.26 24 Yes No 5 3 1 2
R:R:H160 R:R:R112 13.54 24 Yes Yes 3 5 1 1
L:L:L72 R:R:R112 8.5 24 Yes Yes 0 5 0 1
R:R:K126 R:R:Y127 19.11 0 No Yes 5 6 2 1
R:R:E148 R:R:K126 10.8 38 No No 5 5 1 2
R:R:I152 R:R:Y127 19.34 0 No Yes 4 6 2 1
L:L:Y112 R:R:Y127 31.77 23 Yes Yes 0 6 0 1
R:R:E154 R:R:S129 2.87 7 Yes No 7 7 1 2
R:R:C131 R:R:E154 3.04 7 No Yes 7 7 2 1
R:R:C131 R:R:C156 5.46 7 No Yes 7 7 2 1
R:R:D157 R:R:N132 2.69 0 No Yes 6 8 2 1
L:L:L72 R:R:N132 5.49 24 Yes Yes 0 8 0 1
L:L:V73 R:R:N132 5.91 0 No Yes 0 8 0 1
R:R:G134 R:R:H160 7.94 24 No Yes 5 3 2 1
R:R:H160 R:R:R136 9.03 24 Yes No 3 3 1 2
R:R:E148 R:R:S149 2.87 38 No No 5 3 1 1
L:L:Y89 R:R:E148 3.37 38 No No 0 5 0 1
L:L:Y89 R:R:S149 2.54 38 No No 0 3 0 1
M:M:Q66 R:R:N150 2.64 0 No No 0 5 0 1
R:R:C156 R:R:E154 4.56 7 Yes Yes 7 7 1 1
L:L:K115 R:R:E154 6.75 7 Yes Yes 0 7 0 1
R:R:C156 R:R:Y182 4.03 7 Yes Yes 7 6 1 1
M:M:R115 R:R:C156 5.57 7 Yes Yes 0 7 0 1
L:L:L72 R:R:H160 2.57 24 Yes Yes 0 3 0 1
R:R:G183 R:R:Y182 2.9 7 No Yes 7 6 2 1
R:R:E203 R:R:Y182 10.1 7 Yes Yes 5 6 2 1
R:R:K205 R:R:Y182 33.44 7 Yes Yes 7 6 1 1
R:R:E206 R:R:Y182 33.67 7 Yes Yes 4 6 1 1
L:L:K115 R:R:Y182 2.39 7 Yes Yes 0 6 0 1
M:M:R114 R:R:Y182 20.58 7 Yes Yes 0 6 0 1
M:M:R115 R:R:Y182 8.23 7 Yes Yes 0 6 0 1
R:R:E206 R:R:G183 3.27 7 Yes No 4 7 1 2
R:R:E203 R:R:K205 17.55 7 Yes Yes 5 7 2 1
R:R:D228 R:R:E203 9.09 7 Yes Yes 9 5 2 2
R:R:E206 R:R:K205 6.75 7 Yes Yes 4 7 1 1
R:R:D228 R:R:K205 8.3 7 Yes Yes 9 7 2 1
L:L:S116 R:R:K205 4.59 7 No Yes 0 7 0 1
M:M:R114 R:R:K205 9.9 7 Yes Yes 0 7 0 1
R:R:E206 R:R:S231 2.87 7 Yes No 4 6 1 2
M:M:R114 R:R:E206 11.63 7 Yes Yes 0 4 0 1
M:M:R115 R:R:E206 3.49 7 Yes Yes 0 4 0 1
R:R:R247 R:R:T226 5.17 0 Yes No 5 4 1 2
R:R:Q246 R:R:R247 18.69 0 No Yes 6 5 2 1
R:R:E270 R:R:R247 4.65 0 No Yes 6 5 2 1
M:M:P70 R:R:R247 12.97 0 No Yes 0 5 0 1
M:M:R63 R:R:Y331 33.95 40 No No 0 1 0 1
M:M:L72 R:R:Y331 7.03 40 Yes No 0 1 0 1
L:L:G96 R:R:F335 1.51 0 No No 0 1 0 1
R:R:D330 R:R:Y331 1.15 0 No No 4 1 2 1
L:L:F98 R:R:F335 1.07 10 Yes No 0 1 0 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
100.00Single6D35Cholesterol6D35-SMO-Cholesterol
100.00Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
100.00Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
100.00Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
100.00Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
100.00Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
100.00Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
100.00Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
100.00Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-PubChem 7023848
100.00Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
100.00Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626-Phospholipid
100.00Single7DD5Ca37DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
100.00Single7DTTCa7DTT-CaS-Ca-Ca
100.00Single7DTTCa7DTT-CaS-Ca-Ca
100.00Single7DTUTryptophan7DTU-CaS-Tryptophan
100.00Single7DTUTryptophan7DTU-CaS-Tryptophan
100.00Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
100.00Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
100.00Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
100.00Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
100.00Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
100.00Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
100.00Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
100.00Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
100.00Single7EB2Baclofen7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
100.00Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
100.00Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
100.00Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
100.00Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
100.00Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
100.00Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
100.00Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
100.00Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
100.00Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
100.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
100.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
100.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
100.00Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
100.00Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
100.00Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
100.00Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
100.00Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
100.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7T9NM22 Fab7T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
100.00Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
100.00Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
100.00Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
100.00Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
100.00Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
100.00Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
100.00Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
100.00Single7XW7K1-707XW7-TSH-K1-70
100.00Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
100.00Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
100.00Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
100.00Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
100.00Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
100.00Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
100.00Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
100.00Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
100.00Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
100.00Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
100.00Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
100.00Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
100.00Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-J9R
100.00Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
100.00Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
100.00Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
100.00Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
100.00Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
100.00Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
100.00Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
100.00Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
100.00Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
100.00Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
100.00Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
100.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
100.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
100.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
100.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
100.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
100.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
100.00Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
100.00Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
100.00Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
100.00Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
100.00Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
100.00Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
100.00Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
100.00Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
100.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
100.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
100.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
100.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
100.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
100.00Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
100.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
100.00Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
100.00Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
100.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
100.00Consensusclass-c_offOrthosteric Ligandgabab_off mglu_off
100.00Consensusclass-c_offOrthosteric Ligandgabab_off mglu_off
100.00Consensusclass-c_onOrthosteric Ligandgabab_on mglu_on
100.00Consensusclass-c_onOrthosteric Ligandgabab_on mglu_on
100.00Consensusfsh_on_alloOrthosteric Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
100.00Consensusgabab_offOrthosteric Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
100.00Consensusgabab_onOrthosteric Ligand7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
100.00Consensusgi_class-cOrthosteric Ligandgi_mglu gi_gaba
100.00Consensusgi_class-cOrthosteric Ligandgi_mglu gi_gaba
100.00Consensusgi_gabaOrthosteric Ligand7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
100.00Consensusgi_mgluOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00Consensusgi_mgluOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00Consensusgphr_onOrthosteric Ligandlh_on tsh_on
100.00Consensusgs_gphrOrthosteric Ligand7T9I-TSH-TSH-Gs/&β;1/&γ;2 7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
100.00Consensusgs_proteinOrthosteric Ligandgs_gphr
100.00Consensuslh_onOrthosteric Ligand7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
100.00Consensuslh_on_alloOrthosteric Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
100.00Consensusmglu2_offOrthosteric Ligand7MTQ-mGlu2; mGlu2-LY341495
100.00Consensusmglu2_offOrthosteric Ligand7MTQ-mGlu2; mGlu2-LY341495
100.00Consensusmglu2_onOrthosteric Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
100.00Consensusmglu2_onOrthosteric Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
100.00Consensusmglu3_offOrthosteric Ligand7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
100.00Consensusmglu3_offOrthosteric Ligand7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
100.00Consensusmglu4_onOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00Consensusmglu4_onOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00Consensusmglu5_offOrthosteric Ligand7FD9-mGlu5; mGlu5-LY341495
100.00Consensusmglu5_offOrthosteric Ligand7FD9-mGlu5; mGlu5-LY341495
100.00Consensusmglu_offOrthosteric Ligandmglu2_off mglu3_off mglu5_off
100.00Consensusmglu_offOrthosteric Ligandmglu2_off mglu3_off mglu5_off
100.00Consensusmglu_onOrthosteric Ligandmglu2_on mglu4_on
100.00Consensusmglu_onOrthosteric Ligandmglu2_on mglu4_on
100.00Consensussmo_off_alloOther Ligand6D32-SMO-Cyclopamine-Cyclopamine
100.00Consensustsh_onOrthosteric Ligand7T9I-TSH-TSH-Gs/&β;1/&γ;2
100.00Consensustsh_on_alloOrthosteric Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
50.00Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
50.00Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
33.33Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
33.33Single7T9MCS-17 Antibody7T9M-TSH-CS-17 Antibody
33.33Single8HS2Fab0468HS2-GPR20-Fab046
25.00Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
25.00Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
25.00Single7UTZTR14027UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
25.00Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
25.00Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
20.00Single5L7DCholesterol5L7D-SMO-Cholesterol
20.00Single7T9ITSH7T9I-TSH-TSH-Gs/&β;1/&γ;2
20.00Single8HSCFab0468HSC-GPR20-Fab046-Gi1/&β;1/&γ;2
20.00Single8I2GGlycoprotein hormones alpha chain8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
16.67Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
16.67Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/&β;1/&γ;2
14.29Single4XNWMRS25004XNW-P2Y1-MRS2500
14.29Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
14.29Single6LI0GTPL98046LI0-GPR52-GTPL9804
14.29Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
14.29Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
14.29Consensussmo_off_alloOrthosteric Ligand6D32-SMO-Cyclopamine-Cyclopamine
12.50Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
12.50Single4O9RCyclopamine4O9R-SMO-Cyclopamine
12.50Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
12.50Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
12.50Consensusgo_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
12.50Consensusgo_proteinOrthosteric Ligandgo_chemokine
12.50Consensussmo_on_alloOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
11.11Single4BWBNeurotensin4BWB-NTS1-Neurotensin
11.11Single4QINSAG1.54QIN-SMO-SAG1.5
11.11Single5U09Taranabant5U09-CB1-Taranabant
11.11Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
11.11Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
11.11Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
11.11Single6WWZCCL206WWZ-CCR6-CCL20-Go/&β;1/&γ;2
11.11Single7BR3Elagolix7BR3-GnRH1-Elagolix
11.11Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
11.11Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
11.11Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
11.11Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
11.11Single8FN0Neurotensin/neuromedin N8FN0-NTS1-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
11.11Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
11.11Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
11.11Consensusclass-f_offOrthosteric Ligandsmo_off
11.11Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
11.11Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
11.11Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
10.00Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
10.00Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
10.00Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
10.00Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
10.00Single7VV6C48/807VV6-MRGPRX2-C48/80
10.00Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
10.00Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
10.00Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.00Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
10.00Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
10.00Consensuscxcr_onOrthosteric Ligandcxcr1_on cxcr2_on
10.00Consensusgi_class-fOrthosteric Ligandgi_frizzled
10.00Consensusgi_frizzledOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
10.00Consensusgnrh_offOrthosteric Ligandgnrh1_off
10.00Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
10.00Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
10.00Consensuss1p_offOrthosteric Ligands1p1_off
9.09Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
9.09Single5T04Neurotensin5T04-NTS1-Neurotensin
9.09Single5TGZAM65385TGZ-CB1-AM6538
9.09Single6D27CAY104716D27-DP2-CAY10471
9.09Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
9.09Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
9.09Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
9.09Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
9.09Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
9.09Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
9.09Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
9.09Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
9.09Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
9.09Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
9.09Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
9.09Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
9.09Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
9.09Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
9.09Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
9.09Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
9.09Consensussmo_offOrthosteric Ligand5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
8.33Single4JKVTaladegib (LY2940680)4JKV-SMO-Taladegib (LY2940680)
8.33Single5C1MBU725C1M-μ-BU72
8.33Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
8.33Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
8.33Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
8.33Single7C4SS1P7C4S-S1P3-S1P
8.33Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
8.33Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
8.33Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
8.33Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
8.33Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
8.33Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
8.33Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
8.33Single7YXAONO-54306087YXA-S1P5-ONO-5430608
8.33Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
8.33Single8JPCNeurotensin 8-138JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
7.69Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
7.69Single4BV0Neurotensin4BV0-NTS1-Neurotensin
7.69Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
7.69Single5V56TC1145V56-SMO-TC114
7.69Single5V57TC1145V57-SMO-TC114
7.69Single6OS1TRV0266OS1-AT1-TRV026
7.69Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
7.69Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
7.69Single7F1TMIP-1a7F1T-CCR5-MIP-1a
7.69Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
7.69Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1
7.69Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/&β;1/&γ;1
7.69Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
7.69Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
7.69Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
7.69Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
7.69Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
7.69Single8E0GBU728E0G-μ-BU72
7.69Single8FMZNeurotensin/neuromedin N8FMZ-NTS1-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.69Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
7.69Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
7.69Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
7.69Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
7.69Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
7.69Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
7.69Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
7.69Consensuslpa_offOrthosteric Ligandlpa1_off
7.69Consensuslpa_onOrthosteric Ligandlpa1_on
7.69Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
7.69Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
7.14Single4GRVNeurotensin 8-134GRV-NTS1-Neurotensin 8-13
7.14Single4XEENeurotensin4XEE-NTS1-Neurotensin
7.14Single4XESNeurotensin4XES-NTS1-Neurotensin
7.14Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
7.14Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
7.14Single6OS2TRV0266OS2-AT1-TRV026
7.14Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/&β;1/&γ;2
7.14Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
7.14Single6YVRNTS8-136YVR-NTS1-NTS8-13
7.14Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
7.14Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
7.14Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
7.14Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
7.14Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
7.14Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.14Single8JPBNeurotensin 8-138JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
7.14Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.14Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
7.14Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
7.14Consensuschemokine_offOrthosteric Ligandcxcr_off
7.14Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
7.14Consensuscxcr_offOrthosteric Ligandcxcr4_off
7.14Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
7.14Consensusdp_offOrthosteric Liganddp2_off
7.14Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
7.14Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
7.14Consensusnts1_onOrthosteric Ligand6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
7.14Consensusnts_onOrthosteric Ligandnts1_on
7.14Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
7.14Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
6.67Single4BUONeurotensin4BUO-NTS1-Neurotensin
6.67Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
6.67Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
6.67Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
6.67Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
6.67Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
6.67Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
6.67Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
6.67Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.67Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
6.67Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
6.67Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
6.67Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
6.67Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
6.67Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
6.67Consensusgi_neurotensinOrthosteric Ligand7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
6.67Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
6.25Single6KNMJN241-96KNM-Apelin-JN241-9
6.25Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
6.25Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
6.25Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
6.25Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
6.25Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
6.25Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
6.25Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.25Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
6.25Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
6.25Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
6.25Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
6.25Consensuslpl_offOrthosteric Ligands1p_off lpa_off
6.25Consensuslpl_onOrthosteric Ligands1p_on lpa_on
6.25Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
6.25Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.25Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.25Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
5.88Single4XT1Fractalkine4XT1-US28-Fractalkine
5.88Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
5.88Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
5.88Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
5.88Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
5.88Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
5.88Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
5.88Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
5.88Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
5.88Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
5.88Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
5.88Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
5.88Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
5.88Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
5.88Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
5.88Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
5.88Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
5.56Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
5.56Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
5.56Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
5.56Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
5.56Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
5.56Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
5.56Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
5.56Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
5.56Single7SK5CXCL127SK5-ACKR3-CXCL12
5.56Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
5.56Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
5.56Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.56Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
5.56Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
5.56Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
5.26Single3OE0CVX153OE0-CXCR4-CVX15
5.26Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
5.26Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
5.26Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
5.26Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
5.26Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
5.26Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
5.26Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
5.26Consensusangiotensin_onOrthosteric Ligandat1_on
5.26Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
5.26Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
5.26Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
5.26Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
5.26Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
5.26Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.26Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.26Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
5.26Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
5.26Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
5.00Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
5.00Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
5.00Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
5.00Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
5.00Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
5.00Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
5.00Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
5.00Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
5.00Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
5.00Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
5.00Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.00Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
5.00Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.00Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
5.00Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
5.00Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
5.00Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
5.00Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
5.00Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
5.00Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
5.00Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
5.00Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
5.00Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
5.00Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
5.00Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
4.76Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
4.76Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
4.76Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
4.76Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
4.76Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
4.76Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
4.76Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
4.76Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
4.76Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
4.76Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
4.76Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
4.76Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
4.76Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
4.76Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
4.76Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
4.76Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
4.76Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
4.76Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
4.76Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
4.55Single4XT3Fractalkine4XT3-US28-Fractalkine
4.55Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
4.55Single6FJ3PTH6FJ3-PTH1-PTH
4.55Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
4.55Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
4.55Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
4.55Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
4.55Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
4.55Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
4.55Single7SK3CXCL127SK3-ACKR3-CXCL12
4.55Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
4.55Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
4.55Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
4.55Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
4.55Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
4.55Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
4.55Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
4.55Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
4.55Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
4.55Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
4.55Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
4.55Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
4.55Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
4.55Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
4.35Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
4.35Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
4.35Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
4.35Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
4.35Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
4.35Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
4.35Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
4.35Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
4.35Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
4.35Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
4.35Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
4.35Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
4.35Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
4.35Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
4.35Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
4.35Consensusgo_class-b1Orthosteric Ligandgo_crf
4.35Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
4.35Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
4.17Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
4.17Single6LMLGlucagon6LML-Glucagon-Glucagon
4.17Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
4.17Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
4.17Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
4.17Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
4.17Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
4.17Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
4.17Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
4.17Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
4.17Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
4.17Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
4.17Single8IY6Endothelin-18IY6-ETB-Endothelin-1
4.17Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
4.17Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
4.17Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
4.17Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
4.17Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
4.17Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
4.17Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
4.17Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
4.17Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
4.17Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
4.00Single5GLHEndothelin-15GLH-ETB-Endothelin-1
4.00Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
4.00Single6IGKEndothelin-36IGK-ETB-Endothelin-3
4.00Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
4.00Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
4.00Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
4.00Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
4.00Single7TYIAmylin7TYI-CT-Amylin-Gs/&β;1/&γ;2
4.00Single7TYLAmylin7TYL-CT-Amylin-Gs/&β;1/&γ;2
4.00Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
4.00Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/&β;1/&γ;2; RAMP2
4.00Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
4.00Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
4.00Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
3.85Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
3.85Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
3.85Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
3.85Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
3.85Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
3.85Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
3.85Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
3.85Consensusglp_onOrthosteric Ligandglp1_on glp2_on
3.85Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
3.70Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
3.70Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
3.70Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
3.70Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
3.70Single8F0KPramlintide analogue san3858F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
3.70Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
3.70Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
3.70Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
3.70Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
3.70Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
3.57Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
3.57Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
3.57Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
3.57Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
3.57Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
3.57Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
3.57Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
3.57Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
3.57Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
3.57Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
3.57Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
3.57Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
3.57Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
3.45Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
3.45Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
3.45Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
3.45Consensuspth_onOrthosteric Ligandpth1_on pth2_on
3.33Single8F2APramlintide analogue san3858F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
3.33Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
3.23Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
3.23Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
3.23Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
3.12Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
3.12Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
3.12Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
3.03Single8F2BPramlintide analogue san458F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
3.03Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
3.03Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.94Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
2.94Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
2.86Single8F0JPramlintide analogue san458F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2

PDB Summary
PDB 7FII
Class A
SubFamily Protein
Type Glycoprotein hormone
SubType LH
Species Homo sapiens
Ligand hCG
Other Ligand(s) -
Protein Partners 6fuf
PDB Resolution 4.3
Date 2021-09-29
D.O.I. 10.1038/s41586-021-03924-2
Net Summary
Imin 2.34
Number of Linked Nodes 1340
Number of Links 1628
Number of Hubs 261
Number of Links mediated by Hubs 917
Number of Communities 50
Number of Nodes involved in Communities 417
Number of Links involved in Communities 607
Path Summary
Number Of Nodes in MetaPath 421
Number Of Links MetaPath 420
Number of Shortest Paths 194981859
Length Of Smallest Path 3
Average Path Length 128
Length of Longest Path 123
Minimum Path Strength 1.185
Average Path Strength 8.07897
Maximum Path Strength 25.7
Minimum Path Correlation 0.71
Average Path Correlation 1
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.5625
Average % Of Corr. Nodes 87.5321
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 66.5858
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainB
ProteinG Protein β Sub unit
UniProtP54311
Sequence
>7FII_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP63212
Sequence
>7FII_Chain_G
TASIAQARK LVEQLKMEA NIDRIKVSK AAADLMAYC EAHAKEDPL 
LTPVPASEN PFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP22888
Sequence
>7FII_Chain_R
EPCNCVPDG ALRCPGPTA GLTRLSLAY LPVKVIPSQ AFRGLNEVI 
KIEISQIDS LERIEANAF DNLLNLSEI LIQNTKNLR YIEPGAFIN 
LPRLKYLSI CNTGIRKFP DVTKVFSSE SNFILEICD NLHITTIPG 
NAFQGMNNE SVTLKLYGN GFEEVQSHA FNGTTLTSL ELKENVHLE 
KMHNGAFRG ATGPKTLDI SSTKLQALP SYGLESIQR LIATSSYSL 
KKLPSRETF VNLLEATLT YPSHCCAFR NLPDYEYGF CLPKTPRCA 
PEPDAFNPC EDIMGYDFL RVLIWLINI LAIMGNMTV LFVLLTSRY 
KLTVPRFLM CNLSFADFC MGLYLLLIA SVDSQTKGQ YYNHAIDWQ 
TGSGCSTAG FFTVFASEL SVYTLTVIT LERWHTITY AIHLDQKLR 
LRHAILIML GGWLFSSLI AMLPLVGVS NYMKVSICF PMDVETTLS 
QVYILTILI LNVVAFFII CACYIKIYF AVRNPELMA TNKDTKIAK 
KMAILIFTD FTCMAPISF FAISAAFKV PLITVTNSK VLLVLFYPI 
NSCANPFLY AIFTKTFQR DFFLLLSKF GCC


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainA
ProteinG Protein α Sub unit
UniProtP04896
Sequence
>7FII_Chain_A
CTLSAEDKA AVERSKMIE KQLQKDKQV YRATHRLLL LGADNSGKS 
TIVKQMRIY HVNGTSGIF ETKFQVDKV NFHMFDVGA QRDERRKWI 
QCFNDVTAI IFVVDSSDY NRLQEALND FKSIWNNRW LRTISVILF 
LNKQDLLAE KVLAGKSKI EDYFPEFAR YTTPEDATP EPGEDPRVT 
RAKYFIRDE FLRISTASG DGRHYCYPH FTCSVDTEN ARRIFNDCR 
DIIQRMHLR QYELL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
5OLHANucleotideAdenosineA2AHomo sapiensVipadenantNa-2.62018-01-1710.1038/s41598-017-18570-w
5GLHAPeptideEndothelinETBHomo sapiensEndothelin-1--2.82016-09-0710.1038/nature19319
7FIGAProteinGlycoprotein hormoneLHHomo sapienshCG-chim(NtGi1L-Gs)/&β;1/&γ;23.92021-09-2910.1038/s41586-021-03924-2
7FIHAProteinGlycoprotein hormoneLHHomo sapienshCGOrg43553chim(NtGi1-Gs)/&β;1/&γ;23.22021-09-2910.1038/s41586-021-03924-2
7FIIAProteinGlycoprotein hormoneLHHomo sapienshCG-6fuf4.32021-09-2910.1038/s41586-021-03924-2
7FIJAProteinGlycoprotein hormoneLHHomo sapiens---3.82021-09-2910.1038/s41586-021-03924-2
6ZFZAAmineAcetylcholine (muscarinic)M1Homo sapiens77-LH-28-1--2.172021-10-0610.1016/j.cell.2021.11.001




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