Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
1G.S1.02 4.1645565
2G.H1.01 4.07375409
3G.H1.04 3.02875407
4G.S2.08 7.56125465
5G.S3.01 4.92438464
6G.S3.03 7.6095567
7G.S3.04 9.02125416
8G.S3.05 3.346567
9G.S3.06 6.6915515
10G.s3h2.03 4.805419
11G.H2.03 5.85812419
12G.H2.06 4.725719
13G.H2.07 4.836519
14G.h2s4.01 5.9715519
15G.S4.04 6.1475439
16G.s4h3.04 6.9925128
17G.s4h3.05 7.769384129
18G.H3.01 4.424384189
19G.H3.02 2.9175438
20G.H3.06 3.50312436
21G.H3.09 6.14062439
22G.H3.13 3.61435
23G.H3.15 4.40375418
24G.H3.17 7.792515
25G.H3.18 5.90312419
26G.S5.04 3.6505539
27G.S5.05 3.7445119
28G.S5.06 4.75187408
29G.HG.04 5.9754129
30G.HG.08 4.006884126
31G.hgh4.02 5.11429737
32G.hgh4.05 8.15438407
33G.H4.15 4.1705538
34G.h4s6.02 4.67438
35G.h4s6.12 5.09062404
36G.S6.02 5.13687407
37G.s6h5.01 5.818124119
38G.s6h5.05 4.984119
39G.H5.03 6.07055118
40G.H5.05 4.18187465
41G.H5.06 4.62125403
42G.H5.08 4.47643768
43G.H5.17 3.559384155
44G.H5.21 3.32155155
45G.H5.26 5.58055155
46b.1x19 4.06375446
47b.lhb1x3 2.42563402
48b.lhb1x6 3.00754173
49b.b1x4 3.46438487
50b.l1x3 8.885109
51b.b2x1 5.7465518
52b.b2x5 7.44375407
53b.l3x2 5.5395109
54b.b4x3 3.0805597
55b.b4x6 10.7235109
56b.l4x2 10.1525484
57b.b5x2 4.80437407
58b.b5x3 6.52455109
59b.b5x5 4.89188405
60b.b5x7 4.72437497
61b.l5x1 3.4498
62b.l5x5 6.38893719
63b.b7x1 5.33188404
64b.b7x4 2.877598
65b.b8x3 3.125406
66b.b8x4 3.92714796
67b.l8x8 3.93563494
68b.b9x3 4.3225496
69b.l9x3 5.66857719
70b.l9x6 4.34625818
71b.b10x4 4.47813456
72b.b10x5 3.72333609
73b.l10x1 3.83687403
74b.l11x2 9.33937419
75b.b12x2 4.39687417
76b.b12x6 7.8725718
77b.b12x7 4.62055239
78b.b13x7 7.354557
79b.l13x3 6.67958659
80b.l13x6 4.69708619
81b.b14x1 4.292518
82b.b14x3 3.57313455
83b.b14x5 2.80625455
84b.b15x1 6.90375459
85b.b15x2 5.38375446
86b.l15x1 4.7035517
87b.l15x2 5.68459
88b.b16x4 10.3088456
89b.b16x6 8.6395558
90b.b17x7 5.90812448
91b.l17x3 7.17167649
92b.b18x3 5.20687448
93b.b18x5 6.25812445
94b.l18x1 5.028217146
95b.l18x2 5.216884147
96b.b19x2 5.00179746
97b.l19x2 6.0875549
98b.b20x4 8.207548
99b.b20x6 6.34546
100b.l20x2 7.33688409
101b.b21x1 7.565547
102b.b21x5 3.5474
103b.b21x7 4.39208675
104b.b22x5 4.586147
105b.l22x5 5.515179
106b.b23x6 5.59607777
107b.l23x1 7.12687406
108b.b24x2 4.7975475
109b.b24x4 4.2885576
110b.b24x5 2.45438405
111b.b24x6 4.766578
112b.l25x3 8.17655139
113b.l26x1 6.47754217
114b.l26x5 4.73812405
115b.l27x1 11.0075519
116b.l27x2 7.556254139
117b.b28x4 7.176254136
118b.b28x6 8.5125139
119g.h1x11 2.67955209
120g.l1x4 4.1145548
121g.h2x11 8.09254146
122g.ctx3 6.0575409
123g.ctx6 2.62455176
124g.ctx14 4.5295589
125g.ctx16 4.44806988
126Lig 14.23923420
1271x31 2.51375403
1281x39 4.78438427
1291x43 4.24406
1301x59 4.540634264
1312x41 4.5025406
1322x42 5.58083607
1332x43 6.56688428
1342x45 4.6475409
1352x46 3.151884259
1362x50 4.56755259
137E1x50 7.5135288
138E1x52 7.19407
1393x50 3.7305529
1403x51 6.6875408
1413x53 5.090634168
142I2x53 2.820634165
143I2x57 5.898134167
1444x65 4.6405
145E2.Y192 7.1525405
1465x50 3.04625409
1475x58 6.23125628
1485x62 3.37562405
1496x44 4.35938429
1506x47 6.718754298
1516x48 6.3325529
1526x51 6.93437427
1537x27 3.735423
1548x50 6.17562409
1558x51 2.5875408
1568x53 4.7425404
157b.1x1 1.47813400
158b.1x4 1.55562400
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1b.b2x5 b.l4x1 13.05364.94YesNo075
2b.b27x2 b.b2x5 27.94624.54NoYes057
3b.b27x2 b.b2x3 28.10643.22NoNo056
4b.b26x2 b.b2x3 28.42777.2925NoNo076
5b.b26x1 b.b26x2 28.75043.44NoNo097
6b.b26x1 b.l27x1 28.91464.94NoYes099
7b.b2x1 b.l27x1 45.03243.6175YesYes189
8b.b2x1 b.l3x1 47.036512.4YesNo189
9b.l3x1 b.l5x5 48.72036.575NoYes199
10G.h2s4.01 b.l5x5 64.02949.02YesYes199
11G.S1.05 G.h2s4.01 99.49639.745NoYes099
12G.S1.05 G.S1.07 99.62234.15NoNo099
13G.H3.12 G.S1.07 99.74834.995NoNo089
14G.H3.08 G.H3.12 99.87421.785NoNo098
15G.H3.08 G.S4.04 1003.0475NoYes099
16G.S4.04 G.S4.06 49.89152.62YesNo097
17G.H4.15 G.S4.06 48.97957.535YesNo087
18G.H3.02 G.H4.15 33.00913.4225YesYes388
19G.H3.02 G.hgh4.02 32.74083.2925YesYes387
20G.H4.10 G.hgh4.02 97.45856.9475NoYes367
21G.H4.10 G.hgh4.05 97.387316.135NoYes067
22G.H4.05 G.hgh4.05 97.92283.365NoYes047
23G.H4.02 G.H4.05 97.59494.585NoNo1954
24G.H4.02 G.H4.04 97.46754.23NoNo054
25G.H4.03 G.H4.04 97.31569.26NoNo044
26G.H4.03 G.HG.01 96.55465.3725NoNo045
27G.HG.01 G.s6h5.02 96.40226.0625NoNo057
28G.s6h5.02 G.s6h5.05 95.94435.055NoYes079
29G.H5.03 G.s6h5.05 77.93885.3875YesYes1189
30G.H5.03 G.S6.04 69.22142.87YesNo1189
31G.H5.06 G.S6.04 69.839512.16YesNo039
32G.H5.06 G.S6.02 70.14152.575YesYes037
33G.S6.02 G.h4s6.12 70.2810.945YesYes074
34G.h4s6.12 I3.R233 64.07193.7775YesNo044
35I3.R233 I3.R236 63.90272.13NoNo045
365x66 I3.R236 63.73386.4975NoNo045
375x62 5x66 63.56492.28YesNo054
385x62 6x33 12.57922.9475YesNo057
396x33 G.H5.25 12.39837.7375NoNo077
403x50 G.H5.25 11.88273.9475YesNo097
413x46 3x50 18.83495.3225NoYes289
422x42 3x46 18.54664.99YesNo078
43G.S4.04 G.S5.04 50.00573.65YesYes399
44G.H4.15 G.S5.04 49.80833.6525YesYes389
45G.H3.06 G.H4.15 33.01813.7325YesYes368
46G.H3.06 G.hgh4.02 32.84665.9875YesYes367
47G.H4.11 G.H4.15 32.77552.51NoYes078
48G.H4.11 G.hgh4.02 32.74123.025NoYes077
495x62 6x37 50.49734.47YesNo057
505x58 6x37 50.324913.565YesNo087
513x50 5x58 12.44574.8875YesYes298
52G.s6h5.01 G.s6h5.05 17.32276.865YesYes1199
53G.H1.04 G.S5.05 18.40162.8275YesYes079
54G.H1.04 G.H1.08 23.53453.645YesNo078
55G.H1.08 G.S2.06 14.80853.42NoNo689
56G.S2.06 G.S3.03 14.244916.345NoYes697
57G.H2.07 G.h2s4.01 42.32442.755YesYes199
58G.H2.07 b.l9x6 40.81732.895YesYes198
59b.l25x6 b.l27x1 16.158916.7425NoYes089
60b.l11x1 b.l9x6 38.20373.2625NoYes198
61b.b11x6 b.l11x1 38.11823.71NoNo199
62b.b11x6 b.l9x3 36.567913.5975NoYes199
63b.l9x3 b.l9x7 30.46162.25YesNo097
64b.b8x1 b.l9x7 30.29413.17NoNo087
65b.b10x3 b.b8x1 30.12662.73NoNo088
66b.b10x3 b.b6x2 29.95893.8025NoNo088
67b.b10x2 b.b6x2 29.79122.535NoNo068
68b.b10x2 b.b10x4 24.71433.135NoYes566
69b.b10x4 b.b14x5 23.88383.0375YesYes565
70b.b14x5 b.l10x1 21.5872.7675YesYes053
71b.l10x1 b.l16x1 19.69632.98YesNo034
72b.l16x1 b.l16x2 19.22893.5975NoNo049
73b.l14x5 b.l16x2 19.055611.9925NoNo059
74b.l14x3 b.l14x5 18.88213.2725NoNo055
75b.l14x1 b.l14x3 18.70852.7025NoNo045
76b.b18x5 b.l14x1 18.18734.8525YesNo054
77b.b18x5 b.b19x2 14.27032.4125YesYes456
78b.l26x5 g.ctx4 16.11132.9325YesNo057
79g.ctx3 g.ctx4 15.77353.6225YesNo097
80b.l22x1 g.ctx3 12.85145.8875NoYes099
81b.b23x1 b.l22x1 12.50534.505NoNo059
82b.b23x1 b.b24x5 12.15923.3525NoYes055
83b.b23x3 b.b24x5 10.42713.3525NoYes075
84b.l5x3 b.l5x5 15.3372.4725NoYes089
85b.l5x3 b.l7x3 15.1657.3575NoNo089
86b.b9x3 b.l7x5 14.67234.44YesNo066
87b.l7x3 b.l7x5 14.99327NoNo096
88b.l23x1 b.l25x6 15.981718.76YesNo068
89b.l21x7 b.l23x1 15.30783.5NoYes056
90b.b23x6 b.l21x7 14.44183.0225YesNo775
91b.b23x6 b.b24x6 12.20085.7875YesYes778
92b.b21x7 b.b24x6 11.39496.0275YesYes758
935x54 5x58 36.12414.9825NoYes288
945x54 6x44 36.03672.7425NoYes289
956x44 6x48 30.45337.265YesYes299
966x48 6x51 25.41163.6175YesYes297
976x51 Lig 23.234914.3525YesYes270
98b.l4x1 g.ctx16 10.65514.95NoYes858
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
E2.R178Lig13.92250NoYes0010
E2.F182Lig13.81250NoYes0010
E2.Y181Lig10.42752NoYes0010
LigNT.V268.85752YesNo0001
LigNT.P252.4152YesNo0001
LigNT.D276.64252YesNo0001
E2.E180Lig3.65752NoYes0010
LigNT.T292.7852YesNo0001
E2.D191Lig9.132NoYes0010
E2.H194Lig5.59250NoYes0010
E2x51Lig4.2550NoYes4010
5x36Lig6.752NoYes4010
7x27Lig4.082YesYes3010
E1.H100Lig9.01750NoYes0010
7x31Lig5.232NoYes4010
2x64Lig2.3852NoYes5010
7x34Lig18.8652NoYes4010
7x35Lig4.332NoYes4010
2x60Lig6.4550NoYes6010
3x29Lig2.4652NoYes6010
3x32Lig3.03252NoYes6010
3x33Lig3.582NoYes4010
6x51Lig14.35252YesYes7010
6x54Lig4.1152NoYes4010
6x55Lig4.39752NoYes5010
7x38Lig8.11752NoYes5010
NT.D27NT.T295.78252NoNo0011
1x297x3210.82750NoNo2221
1x357x352.5650NoNo6421
1x362x643.56750NoNo5521
1x397x382.94752YesNo7521
3x283x292.460NoNo5621
3x294x659.72752NoYes6512
3x333x376.742NoNo4712
E2.E179E2.Y1815.050NoNo0021
E2.E180E2.P1832.752NoNo0011
E2.E180E2.K1857.4252NoNo0012
5x36E2.Y19215.712NoYes4012
5x366x593.59252NoNo4512
6x486x513.61752YesYes9721
6x516x526.7652YesNo7812
6x517x413.00252YesNo7812
6x546x553.1852NoNo4511
6x547x376.762NoNo4612
6x587x343.810NoNo4421
7x27E3.P2702.52752YesNo3012
7x277x316.22YesNo3411
7x347x382.5552NoNo4511
E2.L187Lig2.820NoYes0010
E2.D191E2.S1932.5752NoNo0012
E2.P183Lig2.88252NoYes0010
E2.D191E2.V1762.192NoNo0012
6x617x272.13250NoYes2321
7x32Lig2.0752NoYes2010
LigNT.L221.76252YesNo0001
7x28Lig1.7150NoYes3010
2x563x321.62250NoNo6621
E2.P183E2.P1841.46252NoNo0012
NT.P25NT.T241.31252NoNo0012
LigNT.K280.92752YesNo0001
NT.L22NT.N230.68752NoNo0012

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
95.00Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
78.26Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
78.26Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
75.00Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
65.22Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
65.00Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
62.50Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
61.90Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
56.52Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
54.55Consensuslpl_offOrthosteric Ligands1p_off lpa_off
54.17Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
53.57Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
53.57Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
53.57Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
52.17Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
52.00Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
51.85Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
51.72Consensusendothelin_onOrthosteric Ligandetb_on eta_on
50.00Single5GLHEndothelin-15GLH-ETB-Endothelin-1
50.00Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
50.00Single6IGKEndothelin-36IGK-ETB-Endothelin-3
50.00Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
50.00Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
50.00Single8XQJJN2418XQJ-Apelin-JN241
50.00Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
50.00Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
48.39Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
48.28Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
48.28Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
48.15Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
48.00Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
48.00Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
48.00Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
48.00Consensuslpl_onOrthosteric Ligands1p_on lpa_on
48.00Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
48.00Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
47.83Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
47.83Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
47.83Single8XQJJN2418XQJ-Apelin-JN241
47.83Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
47.83Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
47.83Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
47.83Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
47.83Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
47.83Consensuslpa_offOrthosteric Ligandlpa1_off
47.62Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
46.88Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
46.67Single6IGLIRL16206IGL-ETB-IRL1620
46.67Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
46.67Single8IY6Endothelin-18IY6-ETB-Endothelin-1
46.67Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
46.67Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
46.67Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
46.67Consensusbradykinin_onOrthosteric Ligandbk2_on
46.67Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
46.67Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
46.43Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
46.43Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
46.43Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
46.43Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
46.43Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
46.43Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
46.43Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
46.43Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
46.43Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
46.15Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
46.15Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
46.15Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
46.15Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
46.15Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
45.83Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
45.83Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
45.83Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
45.83Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
45.45Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
45.16Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
44.83Single4XT3Fractalkine4XT3-US28-Fractalkine
44.83Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
44.83Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
44.83Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
44.44Single3OE0CVX153OE0-CXCR4-CVX15
44.44Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
44.44Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
44.44Consensusangiotensin_onOrthosteric Ligandat1_on
44.44Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
44.44Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
44.44Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
44.44Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
44.00Single8QJ2pN1628QJ2-MC4-pN162-Gs
44.00Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
43.48Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
43.48Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
43.48Single6OS1TRV0266OS1-AT1-TRV026
43.48Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
43.48Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
43.48Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
43.48Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
43.48Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
43.48Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
43.48Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
43.48Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
42.86Single6JODAngiotensin II6JOD-AT2-Angiotensin II
42.86Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
42.86Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
42.86Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
42.86Single9M2FNeuropeptide FF9M2F-NPFF1-Neuropeptide FF-Gi1/β1/γ2
42.86Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
42.86Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
42.86Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
42.86Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
42.86Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
42.86Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
42.86Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
42.86Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
42.86Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
42.31Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
42.31Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
42.31Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
42.31Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
42.31Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
42.31Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
41.67Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
41.67Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
41.67Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
41.67Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
41.67Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
41.67Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
41.67Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
41.67Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
41.67Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
41.67Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
41.67Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
41.67Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
41.67Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
41.67Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
41.38Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
41.38Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
41.38Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
41.38Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
41.38Single8ZRTET-18ZRT-ETB-ET-1
41.38Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
40.91Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
40.91Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
40.91Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
40.91Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
40.91Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
40.74Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
40.74Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
40.74Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
40.74Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
40.74Single7XNACYN1548067XNA-SST2-CYN154806
40.74Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
40.74Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
40.74Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
40.74Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
40.74Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
40.74Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
40.74Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
40.74Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
40.62Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
40.00Single4BUONeurotensin4BUO-NTS1-Neurotensin
40.00Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
40.00Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
40.00Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
40.00Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
40.00Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
40.00Consensusprostanoid_offOrthosteric Ligandep_off dp_off
39.39Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
39.39Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
39.39Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
39.29Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
39.29Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
39.29Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
39.29Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
39.29Single9U4WGonadoliberin-19U4W-GnRH1-Gonadoliberin-1-chim(NtGi1L-Gs-CtGq)/β1/γ2
39.29Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
39.29Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
39.29Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
39.13Single6D26Fevipiprant6D26-DP2-Fevipiprant
39.13Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
39.13Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
39.13Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
39.13Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
39.13Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
39.13Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
39.13Single9CIBFCH-22964139CIB-HCA2-FCH-2296413
39.13Single9EHSLUF76029EHS-A3A-LUF7602
39.13Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
39.13Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
39.13Consensusdp_offOrthosteric Liganddp2_off
38.89Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
38.71Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
38.71Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
38.71Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
38.71Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
38.71Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
38.71Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
38.71Single9KDFRES-701-39KDF-ETB-RES-701-3
38.71Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
38.71Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
38.46Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
38.46Single6KNMJN241-96KNM-Apelin-JN241-9
38.46Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
38.46Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
38.46Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
38.46Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
38.46Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
38.46Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
38.46Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
38.46Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
38.46Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
38.46Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
38.46Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
38.46Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
38.46Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
38.46Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
38.24Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
38.10Single8GNGIstradefylline8GNG-A2A-Istradefylline
38.10Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
38.10Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
37.93Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
37.93Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
37.93Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
37.93Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
37.93Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
37.93Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
37.93Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
37.93Single8ZBISomatostatin-148ZBI-SST3-Somatostatin-14-Gi1/β1/γ2
37.93Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
37.93Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
37.50Single4BV0Neurotensin4BV0-NTS1-Neurotensin
37.50Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
37.50Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
37.50Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
37.50Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
37.50Single8E0GBU728E0G-μ-BU72
37.50Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
37.50Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
37.50Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
37.50Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
37.50Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
37.50Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
37.50Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
37.50Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
37.50Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
37.50Consensuslpa_onOrthosteric Ligandlpa1_on
37.50Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
37.50Consensusneurotensin_onOrthosteric Ligandnts1_on
37.50Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
37.50Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
37.14Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
37.04Single4XT1Fractalkine4XT1-US28-Fractalkine
37.04Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
37.04Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
37.04Single8U4OCXCL128U4O-CXCR4-CXCL12-Gi1/β1/γ2
37.04Single8WDTphotoNECA8WDT-A2A-photoNECA
37.04Single8XWNCXCL88XWN-CXCR2-CXCL8
37.04Single9BUYLM1899BUY-β2-LM189-Gi1/β1/γ2
37.04Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
37.04Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
37.04Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
37.04Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
37.04Consensussomatostatin_offOrthosteric Ligandsst2_off
37.04Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
36.67Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
36.67Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
36.67Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
36.67Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
36.67Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
36.67Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
36.67Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
36.36Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
36.36Single7AROLUF58337ARO-A2A-LUF5833-Na
36.36Single7F61PF-036547467F61-H3-PF-03654746
36.36Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
36.36Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
36.36Single9JMDAzithromycin9JMD-Motilin-Azithromycin-chim(Gs-CtGq)/β1/γ2
36.36Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
36.36Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
36.36Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
36.36Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
36.00Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
36.00Single4XEENeurotensin4XEE-NTS1-Neurotensin
36.00Single4XESNeurotensin4XES-NTS1-Neurotensin
36.00Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
36.00Single6OS2TRV0266OS2-AT1-TRV026
36.00Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
36.00Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
36.00Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
36.00Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
36.00Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
36.00Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
36.00Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
36.00Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
36.00Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
36.00Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
36.00Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
36.00Consensusorexin_onOrthosteric Ligandox2_on
35.71Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
35.71Single9IQVMuscarinic toxin 39IQV-Alpha1A-Muscarinic toxin 3
35.71Single9J0FNADH9J0F-P2Y14-NADH-Gi1/β1/γ2
35.71Single9KFIRelaxin-39KFI-RXFP3-Relaxin-3-Gi2/β1/γ2
35.71Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
35.71Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
35.71Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
35.71Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
35.71Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
35.48Single7SK3CXCL127SK3-ACKR3-CXCL12
35.48Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
35.48Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
35.48Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
35.48Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
35.48Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
35.29Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
35.29Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
35.14Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
34.78Single5UENDU1725UEN-A1-DU172
34.78Single6D27CAY104716D27-DP2-CAY10471
34.78Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
34.78Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
34.78Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
34.78Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
34.78Single7V3ZCP559407V3Z-CB1-CP55940
34.78Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
34.78Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
34.78Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
34.78Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
34.78Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
34.78Single9IZCMK19039IZC-HCA2-MK1903-Gi1/β1/γ2
34.78Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
34.78Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
34.78Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
34.78Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
34.78Consensushca_on_gpOrthosteric Ligandhca2_on_gp
34.78Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
34.78Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
34.62Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
34.62Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
34.62Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
34.62Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
34.62Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
34.62Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
34.62Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-SBI-553-chim(NtGi1-Go)/β1/γ2
34.62Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
34.62Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
34.62Single8JPFNeurotensin8JPF-NTS1-Neurotensin-SBI-553
34.62Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
34.62Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
34.62Single8ZPLHF511168ZPL-CXCR4-HF51116
34.62Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
34.62Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
34.62Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
34.62Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
34.62Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
34.62Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
34.62Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
34.62Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
34.48Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
34.48Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
34.48Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
34.48Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
34.48Single9M1OMorphine-Modulating Neuropeptide B9M1O-NPFF2-Morphine-Modulating Neuropeptide B-Gi1/β1/γ2
34.48Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
34.48Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
34.48Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
34.48Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
34.48Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
34.48Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
34.38Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
34.38Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
34.38Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
33.33Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
33.33Single5C1MBU725C1M-μ-BU72
33.33Single5ZTYAM102575ZTY-CB2-AM10257
33.33Single7C61Ergotamine7C61-5-HT1B-Ergotamine
33.33Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
33.33Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
33.33Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
33.33Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
33.33Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
33.33Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
33.33Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
33.33Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
33.33Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
33.33Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
33.33Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
33.33Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
33.33Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
33.33Single8S4DCMF-0198S4D-Apelin-CMF-019
33.33Single8TF5Oleic acid8TF5-GPR6-Oleic acid
33.33Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
33.33Single8Y72Peptide8Y72-μ-Peptide-BMS-986122-Gi1/β1/γ2
33.33Single8ZYTNeurotensin peptide 8-138ZYT-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
33.33Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
33.33Single9I52A1IZU9I52-D1-A1IZU-Gs/β1/γ2
33.33Single9IPVJR14a9IPV-C3aB-JR14a-Gi1/β1/γ2
33.33Single9M0RNeuropeptide VF9M0R-NPFF1-Neuropeptide VF-Gi1/β1/γ2
33.33Single9V2NMacimorelin9V2N-Ghrelin-Macimorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
33.33Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
33.33Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
33.33Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
33.33Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
33.33Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
33.33Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
33.33Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
33.33Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
33.33Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
33.33Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
33.33Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
33.33Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
33.33Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
33.33Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
33.33Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
33.33Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
33.33Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
33.33Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
33.33Consensusvasop-oxy_onOrthosteric Ligandv2_on
33.33Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
32.35Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
32.35Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
32.35Consensusbombesin_onOrthosteric Ligandbb2_on
32.35Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
32.35Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
32.26Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
32.26Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
32.26Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
32.26Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
32.26Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
32.26Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
32.26Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
32.14Single4IARErgotamine4IAR-5-HT1B-Ergotamine
32.14Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
32.14Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
32.14Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
32.14Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
32.14Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
32.14Single8IEBA1LYA8IEB-GPR156-A1LYA
32.14Single8WKYPG-9348WKY-MC4-PG-934
32.14Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
32.14Single8ZBJSomatostatin-148ZBJ-SST5-Somatostatin-14-Gi1/β1/γ2
32.14Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
32.14Single9HB3Mambaquaretin-19HB3-V2-Mambaquaretin-1
32.14Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
32.14Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
32.14Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
32.14Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
32.00Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
32.00Single5XRAAM115425XRA-CB1-AM11542
32.00Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
32.00Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
32.00Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
32.00Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
32.00Single7F1TMIP-1a7F1T-CCR5-MIP-1a
32.00Single7FEECP559407FEE-CB1-CP55940-ZCZ011
32.00Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
32.00Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
32.00Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
32.00Single7TUYGSK682753A7TUY-GPR183-GSK682753A
32.00Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
32.00Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
32.00Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
32.00Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
32.00Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
32.00Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
32.00Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
32.00Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
32.00Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
32.00Single8ZWFJR14a8ZWF-C3aB-JR14a
32.00Single9IK9SST analogue9IK9-SST1-SST analogue-Gi1/β1/γ2
32.00Single9JMCDS-3801b9JMC-Motilin-DS-3801b-chim(Gs-CtGq)/β1/γ2
32.00Single9UY3Anamorelin9UY3-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
32.00Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
32.00Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
32.00Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
31.82Single3PWHZM-2413853PWH-A2A-ZM-241385
31.82Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
31.82Single4BWBNeurotensin4BWB-NTS1-Neurotensin
31.82Single6DS0Ly2660976DS0-5-HT2B-Ly266097
31.82Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
31.82Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
31.82Single7BR3Elagolix7BR3-GnRH1-Elagolix
31.82Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
31.82Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
31.82Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
31.82Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
31.82Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
31.82Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
31.82Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
31.82Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
31.82Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
31.82Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
31.82Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
31.82Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
31.82Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
31.82Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
31.25Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
31.25Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
31.25Single9KFKRelaxin-39KFK-RXFP4-Relaxin-3-Gi2/β1/γ2
31.25Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
31.25Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
31.03Single3QAKUK-4320973QAK-A2A-UK-432097
31.03Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
31.03Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
31.03Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
31.03Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
31.03Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
31.03Single9E82SDF-1-beta9E82-ACKR3-SDF-1-β-Arrestin2
31.03Single9IK8SST analogue9IK8-SST1-SST analogue-Gi1/β1/γ2
31.03Single9IQRMuscarinic toxin 39IQR-α2a-Muscarinic toxin 3
31.03Single9IQSMuscarinic toxin 39IQS-M4-Muscarinic toxin 3
31.03Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
31.03Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
30.77Single4RWADIPP-NH24RWA-δ-DIPP-NH2
30.77Single6A93Risperidone6A93-5-HT2A-Risperidone
30.77Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
30.77Single6KQICP559406KQI-CB1-CP55940-Org27569
30.77Single6MXTSalmeterol6MXT-β2-Salmeterol
30.77Single6YVRNTS8-136YVR-NTS1-NTS8-13
30.77Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
30.77Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
30.77Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
30.77Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
30.77Single7K15MKD0467K15-BLT1-MKD046-Na
30.77Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
30.77Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
30.77Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
30.77Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
30.77Single7YITNalfurafine7YIT-κ-Nalfurafine
30.77Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
30.77Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
30.77Single8JJLOlodaterol8JJL-β2-Olodaterol
30.77Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
30.77Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
30.77Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
30.77Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
30.77Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
30.77Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
30.77Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
30.77Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
30.77Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
30.77Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
30.77Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
30.77Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
30.43Single3REYXAC3REY-A2A-XAC
30.43Single4MBSMaraviroc4MBS-CCR5-Maraviroc
30.43Single6MH8ZM-2413856MH8-A2A-ZM-241385
30.43Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
30.43Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
30.43Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
30.43Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
30.43Single7T94LY21196207T94-M2-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
30.43Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
30.43Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
30.43Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
30.43Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
30.43Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
30.43Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
30.43Single8K5CAcipimox8K5C-HCA2-Acipimox
30.43Single8RLNLUF58348RLN-A2A-LUF5834
30.43Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
30.43Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
30.43Single8ZPMAMD0708ZPM-CXCR4-AMD070
30.43Single9JFUNE52-QQ579JFU-GPR4-NE52-QQ57
30.43Single9JH3CMF-0199JH3-Apelin-CMF-019-Gi1/β1/γ2
30.43Consensusgrh_offOrthosteric Ligandgnrh1_off
30.43Consensushca_onOrthosteric Ligandhca2_on
30.43Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
30.43Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
30.30Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
30.30Single8W8WAlpha-MSH8W8W-MC3-α-MSH-Ca-Gs/β1/γ2
30.23Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
30.00Single5WF5UK-4320975WF5-A2A-UK-432097
30.00Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
30.00Single6W25SHU91196W25-MC4-SHU9119-Ca
30.00Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
30.00Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
30.00Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
30.00Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
29.63Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
29.63Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
29.63Single6IBLArformoterol6IBL-β1-Arformoterol
29.63Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
29.63Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
29.63Single7EZCUKA7EZC-A2A-UKA
29.63Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
29.63Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
29.63Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
29.63Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
29.63Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
29.63Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
29.63Single8XVUCXCL28XVU-CXCR2-CXCL2
29.63Single8XWFCXCL38XWF-CXCR2-CXCL3
29.63Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
29.63Single8ZWGJR14a8ZWG-C3aB-JR14a-Gi1/β1/γ2
29.63Single9M54Neuropeptide VF9M54-NPFF2-Neuropeptide VF-Gi1/β1/γ2
29.63Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
29.63Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
29.41Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
29.17Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
29.17Single5UIGCmpd-15UIG-A2A-Cmpd-1
29.17Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
29.17Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
29.17Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
29.17Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
29.17Single6XBM5LWE6XBM-SMO-5LWE-Gi1/β1/γ2
29.17Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
29.17Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
29.17Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
29.17Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
29.17Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
29.17Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
29.17Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
29.17Single8K5DGSK2560738K5D-HCA2-GSK256073
29.17Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
29.17Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
29.17Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
29.17Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
29.17Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
29.17Consensuscck_offOrthosteric Ligandccka_off
29.17Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
29.17Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
29.17Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
29.17Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
29.17Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
29.03Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
29.03Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
29.03Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
29.03Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
29.03Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
29.03Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
29.03Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
29.03Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
29.03Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
29.03Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
28.57Single3OE6IT1t3OE6-CXCR4-IT1t
28.57Single4UG2CGS216804UG2-A2A-CGS21680
28.57Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
28.57Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
28.57Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
28.57Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
28.57Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
28.57Single7SK9CCX6627SK9-ACKR3-CCX662
28.57Single7WC5Psilocin7WC5-5-HT2A-Psilocin
28.57Single7XN9L-054,5227XN9-SST2-L-054,522
28.57Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
28.57Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
28.57Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
28.57Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
28.57Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
28.57Single9IPYJR14a9IPY-C3aB-JR14a
28.57Single9IZASCH9002719IZA-HCA2-SCH900271-Gi1/β1/γ2
28.57Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
28.57Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
28.12Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
28.12Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
28.12Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
28.12Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
28.12Single9JFYhNPSF9JFY-NPFF2-hNPSF-Gi1/β1/γ2
28.12Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
28.00Single5IUAQ274563485IUA-A2A-Q27456348-Na
28.00Single5N2RPSB-365N2R-A2A-PSB-36-Na
28.00Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
28.00Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
28.00Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
28.00Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
28.00Single6S0QZM-2413856S0Q-A2A-ZM-241385
28.00Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
28.00Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
28.00Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
28.00Single7C4SS1P7C4S-S1P3-S1P
28.00Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
28.00Single7LD3Adenosine7LD3-A1-Adenosine-MIPS521-Gi2/β1/γ2
28.00Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
28.00Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
28.00Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
28.00Single7W41PD1762527W41-BB2-PD176252
28.00Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
28.00Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
28.00Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
28.00Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
28.00Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
28.00Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
28.00Single8JXSPF-61428JXS-D1-PF-6142
28.00Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
28.00Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
28.00Single8WGBVU01550418WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
28.00Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
28.00Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
28.00Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
28.00Consensusadenosine_offOrthosteric Liganda1_off a2_off
28.00Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
28.00Consensusbombesin_offOrthosteric Ligandbb2_off
28.00Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
28.00Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
28.00Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
27.59Single7F8XNN90567F8X-CCKA-NN9056
27.59Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
27.59Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
27.59Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
27.59Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
27.59Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
27.59Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
27.59Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
27.59Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
27.59Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
27.59Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
27.59Single9J0IUDP-Glucuronic acid9J0I-P2Y14-UDP-Glucuronic acid-Gi1/β1/γ2
27.59Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
27.59Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
27.59Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
27.59Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
27.59Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
27.27Single3OE9IT1t3OE9-CXCR4-IT1t
27.27Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
27.27Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
27.27Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
27.27Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
27.27Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
27.27Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
27.27Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
27.27Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
27.27Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
27.27Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
27.27Single9IZDCHBA9IZD-HCA1-CHBA-Gi1/β1/γ2
27.27Single9LMPNE52-QQ579LMP-GPR4-NE52-QQ57
27.27Consensuspac_on_gpOrthosteric Ligandpac1_on_gp
26.92Single3P0GBI1671073P0G-β2-BI167107
26.92Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
26.92Single5XR8AM8415XR8-CB1-AM841
26.92Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
26.92Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
26.92Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
26.92Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
26.92Single6TQ7SB-3348676TQ7-OX1-SB-334867
26.92Single7B6WCyclazosin7B6W-α1b-Cyclazosin
26.92Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
26.92Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
26.92Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
26.92Single7PX4PSB-21137PX4-A2A-PSB-2113
26.92Single7R0CAVP7R0C-V2-AVP-Arrestin2
26.92Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
26.92Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
26.92Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
26.92Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
26.92Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
26.92Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
26.92Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
26.92Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
26.92Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
26.92Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
26.92Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
26.92Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
26.92Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
26.92Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
26.92Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
26.92Single8Y73Peptide8Y73-μ-Peptide-MPAM-15-Gi1/β1/γ2
26.92Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
26.92Single9EGOYVF9EGO-CB1-YVF-Gi1/β1/γ2
26.92Single9I54A1IZV9I54-D1-A1IZV-Gs/β1/γ2
26.92Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
26.92Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
26.92Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
26.92Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
26.92Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
26.67Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
26.67Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
26.67Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
26.67Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
26.67Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
26.67Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
26.67Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
26.67Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
26.47Single8W8XBeta-MSH8W8X-MC3-β-MSH-Ca-Gs/β1/γ2
26.47Consensusglp_onOrthosteric Ligandglp1_on glp2_on
26.47Consensusglp_on_gpOrthosteric Ligandglp1_on_gp glp2_on_gp
26.32Consensusclass-a_class-b1_cons_on_gpOrthosteric Ligandclass-a_on_gp class-b1_on_gp
26.09Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
26.09Single3ODUIT1t3ODU-CXCR4-IT1t
26.09Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
26.09Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
26.09Single4S0VSuvorexant4S0V-OX2-Suvorexant
26.09Single5WS3EMPA5WS3-OX2-EMPA
26.09Single5ZKQABT-4915ZKQ-PAF-ABT-491
26.09Single6AKXA4R6AKX-CCR5-A4R
26.09Single6AKYMaraviroc6AKY-CCR5-Maraviroc
26.09Single6TPJSuvorexant6TPJ-OX2-Suvorexant
26.09Single7F8YDevazepide7F8Y-CCKA-Devazepide
26.09Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
26.09Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
26.09Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
26.09Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
26.09Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
26.09Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
26.09Single7XRRLemborexant7XRR-OX2-Lemborexant
26.09Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
26.09Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
26.09Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
26.09Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
26.09Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
26.09Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
26.09Single8U4PAMD31008U4P-CXCR4-AMD3100-Gi1/β1/γ2
26.09Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
26.09Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
26.09Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
26.09Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
26.09Single9KPESA09KPE-TAS2R16-SA0-Gi1/β1/γ2
26.09Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
26.09Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
26.09Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
26.09Consensusorexin_offOrthosteric Ligandox2_off ox1_off
26.09Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
26.09Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
26.09Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
26.09Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
26.09Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
26.09Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
25.93Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
25.93Single4LDEBI1671074LDE-β2-BI167107
25.93Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
25.93Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
25.93Single7DFPSpiperone7DFP-D2-Spiperone
25.93Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
25.93Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
25.93Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
25.93Single8JJ8Formoterol8JJ8-β2-Formoterol
25.93Single8JWY2-1188JWY-A2A-2-118
25.93Single8JWZAB9288JWZ-A2A-AB928-Na
25.93Single8XWACXCL18XWA-CXCR2-CXCL1
25.93Single8XWMCXCL68XWM-CXCR2-CXCL6
25.93Single8XWSCXCL58XWS-CXCR2-CXCL5
25.93Single9DGIZ85267113509DGI-CB1-Z8526711350
25.93Single9M4QDoxazosin9M4Q-Alpha1A-Doxazosin
25.93Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
25.93Consensusalpha1_offOrthosteric Ligandalpha1a_off
25.93Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
25.93Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
25.93Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
25.93Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
25.93Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
25.93Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
25.93Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
25.93Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
25.93Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
25.93Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
25.93Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
25.93Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
25.81Single6PT2KGCHM076PT2-δ-KGCHM07
25.81Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
25.81Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.81Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
25.81Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
25.81Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
25.81Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
25.81Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
25.81Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
25.81Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
25.81Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
25.71Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
25.71Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
25.71Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
25.71Single9BYOExendin-39BYO-GLP-1-Exendin-3-Gs/β1/γ2
25.00Single4ZJCSB-6740424ZJC-OX1-SB-674042
25.00Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
25.00Single5IUBQ274563445IUB-A2A-Q27456344-Na
25.00Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
25.00Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
25.00Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
25.00Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
25.00Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
25.00Single5X93K-87945X93-ETB-K-8794
25.00Single6AQFZM-2413856AQF-A2A-ZM-241385
25.00Single6IQLL7458706IQL-D4-L745870
25.00Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
25.00Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
25.00Single6TP3Nemorexant6TP3-OX1-Nemorexant
25.00Single6TPGEMPA6TPG-OX2-EMPA
25.00Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
25.00Single6V9SGTPL114036V9S-OX1-GTPL11403
25.00Single6ZINSR486926ZIN-NTS1-SR48692
25.00Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
25.00Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
25.00Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
25.00Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
25.00Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
25.00Single7T32ZM-2413857T32-A2A-ZM-241385
25.00Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
25.00Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
25.00Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
25.00Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
25.00Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
25.00Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
25.00Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
25.00Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
25.00Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
25.00Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
25.00Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
25.00Single8IHKAcifran8IHK-HCA3-Acifran
25.00Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
25.00Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
25.00Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
25.00Single8K2WAMG4878K2W-CXCR3-AMG487
25.00Single8K9LDamgo8K9L-μ-Damgo-BMS-986122-Gi3/β1/γ1
25.00Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
25.00Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
25.00Single8Y6YGLPG09748Y6Y-FFA2-GLPG0974
25.00Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
25.00Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
25.00Single8ZPNAMD31008ZPN-CXCR4-AMD3100
25.00Single9BA0A1AKN9BA0-CB1-A1AKN
25.00Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
25.00Single9K0KUTP9K0K-P2Y4-UTP-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single9K0XATP9K0X-P2Y2-ATP-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single9K20ATP9K20-P2Y2-ATP-chim(NtGi1-Go)/β1/γ2
25.00Single9KPDSA09KPD-TAS2R16-SA0-chim(Gs-CtGt3)/β1/γ2
25.00Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
25.00Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
25.00Consensuscck_onOrthosteric Ligandccka_on cckb_on
25.00Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
25.00Consensuschemerin_onOrthosteric Ligandcml1_on
25.00Consensusclass-a_class-b1_cons_onOrthosteric Ligandclass-a_on class-b1_on
25.00Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
25.00Consensusendothelin_offOrthosteric Ligandetb_off
25.00Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
25.00Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
25.00Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
25.00Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
24.39Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
24.24Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
24.24Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
24.24Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
24.24Consensuspac_onOrthosteric Ligandpac1_on
24.14Single3NY9ICI118-5513NY9-β2-ICI118-551
24.14Single5WF6UK-4320975WF6-A2A-UK-432097
24.14Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
24.14Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
24.14Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
24.14Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
24.14Single8X5YAstemizole8X5Y-H1-Astemizole
24.14Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
24.14Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
24.14Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
24.14Consensuskisspeptin_onOrthosteric Ligandkiss1_on
24.00Single2Y02Carmoterol2Y02-β1-Carmoterol
24.00Single3EMLZM-2413853EML-A2A-ZM-241385
24.00Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
24.00Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
24.00Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
24.00Single4QIMANTA XV4QIM-SMO-ANTA XV
24.00Single4YAYZD-71554YAY-AT1-ZD-7155
24.00Single5IU8Q274563475IU8-A2A-Q27456347-Na
24.00Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
24.00Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
24.00Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
24.00Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
24.00Single5T04Neurotensin5T04-NTS1-Neurotensin
24.00Single5TGZAM65385TGZ-CB1-AM6538
24.00Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
24.00Single6DRXLisuride6DRX-5-HT2B-Lisuride
24.00Single6GPSMK08126GPS-CCR2-MK0812
24.00Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
24.00Single6PS1Timolol6PS1-β2-Timolol
24.00Single6S0LZM-2413856S0L-A2A-ZM-241385
24.00Single6TOTLemborexant6TOT-OX1-Lemborexant
24.00Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
24.00Single7BU7BI1671077BU7-β1-BI167107
24.00Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
24.00Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
24.00Single7PYRPSB-21157PYR-A2A-PSB-2115
24.00Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
24.00Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
24.00Single7UL4Alvimopan7UL4-μ-Alvimopan
24.00Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
24.00Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
24.00Single7YXAONO-54306087YXA-S1P5-ONO-5430608
24.00Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
24.00Single8CU6LJ-45178CU6-A2A-LJ-4517
24.00Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
24.00Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
24.00Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
24.00Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
24.00Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
24.00Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
24.00Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
24.00Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
24.00Single8ZYYNeurotensin peptide 8-138ZYY-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
24.00Single9CHXS-Carazolol9CHX-β2-S-Carazolol
24.00Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
24.00Single9H37A1IR09H37-A2A-A1IR0-Na
24.00Single9JGKBalovaptan9JGK-5-HT2B-Balovaptan
24.00Single9KFJPubChem 1383196749KFJ-RXFP3-PubChem 138319674-Gi2/β1/γ2
24.00Consensusa3_onOrthosteric Liganda3a_on
24.00Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
24.00Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
23.81Single8A2OTheophylline8A2O-A2A-Theophylline-Na
23.68Consensuscrf_on_gpOrthosteric Ligandcrf2_on_gp crf1_on_gp
23.53Single6FJ3PTH6FJ3-PTH1-PTH
23.53Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
23.53Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
23.53Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
23.33Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
23.33Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
23.33Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
23.33Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
23.33Single8IEIA1LYA8IEI-GPR156-A1LYA
23.33Single8IEIA1LYA8IEI-GPR156-A1LYA
23.33Single8IEPA1LYA8IEP-GPR156-A1LYA
23.33Single8IEPA1LYA8IEP-GPR156-A1LYA
23.33Single8KIGSHU91198KIG-MC3-SHU9119-Ca
23.33Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
23.33Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
23.33Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
23.33Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
23.33Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
23.08Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
23.08Single5N2SPSB365N2S-A1-PSB36
23.08Single5WQCEMPA5WQC-OX2-EMPA
23.08Single5XPRBosentan5XPR-ETB-Bosentan
23.08Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
23.08Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
23.08Single6E67BI1671076E67-β2-BI167107-Gs(CT)
23.08Single6GPXMK08126GPX-CCR2-MK0812
23.08Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
23.08Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
23.08Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
23.08Single6TP6Filorexant6TP6-OX1-Filorexant
23.08Single6Z4SSR486926Z4S-NTS1-SR48692
23.08Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
23.08Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
23.08Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
23.08Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
23.08Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
23.08Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
23.08Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
23.08Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
23.08Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.08Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
23.08Single8QOTNanobody-E8QOT-μ-Nanobody-E
23.08Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
23.08Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.08Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.08Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
23.08Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
23.08Single9B9ZA1AKO9B9Z-CB1-A1AKO
23.08Single9EE8Adenosine9EE8-A2A-Adenosine-Gs/β1/γ2
23.08Single9F33FOB02-04A9F33-D3-FOB02-04A-Go/β1/γ2
23.08Single9F34FOB02-04A9F34-D3-FOB02-04A-Go/β1/γ2
23.08Single9GE2ML1849GE2-GPR55-ML184-chim(NtGi1-G13)/β1/γ2
23.08Single9HAPTolvaptan9HAP-V2-Tolvaptan
23.08Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
23.08Single9KPFSA09KPF-TAS2R16-SA0-Gi1/β1/γ2
23.08Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
23.08Consensusa3_on_gpOrthosteric Liganda3a_on_gp
23.08Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
23.08Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
23.08Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
23.08Consensusblt_offOrthosteric Ligandblt1_off
23.08Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
23.08Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
23.08Consensusep_offOrthosteric Ligandep4_off
23.08Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
23.08Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
23.08Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
23.08Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
22.86Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
22.86Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
22.86Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
22.86Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
22.86Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
22.73Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
22.73Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/β1/γ2
22.73Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
22.73Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
22.73Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
22.73Consensus5ht2_onOrthosteric Ligand5ht2b_on
22.73Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.58Single6HLOAprepitant6HLO-NK1-Aprepitant
22.58Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
22.58Single7SK5CXCL127SK5-ACKR3-CXCL12
22.58Single8IEBA1LYA8IEB-GPR156-A1LYA
22.58Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
22.58Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
22.50Consensusglucagon_on_gpOrthosteric Ligandglp_on_gp gluc_on_gp secretin_on_gp gip_on_gp
22.50Consensuspth_onOrthosteric Ligandpth1_on pth2_on
22.22Single2YDVNECA2YDV-A2A-NECA
22.22Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
22.22Single4DJHJDTic4DJH-κ-JDTic
22.22Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
22.22Single4UHRCGS216804UHR-A2A-CGS21680
22.22Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
22.22Single5G53NECA5G53-A2A-NECA-Gs
22.22Single5TZRMK86665TZR-FFA1-MK8666
22.22Single5V56TC1145V56-SMO-TC114
22.22Single6E59L-7607356E59-NK1-L-760735
22.22Single6H7JIsoprenaline6H7J-β1-Isoprenaline
22.22Single6J20Aprepitant6J20-NK1-Aprepitant
22.22Single6J21Aprepitant6J21-NK1-Aprepitant
22.22Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
22.22Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
22.22Single6WGTLSD6WGT-5-HT2A-LSD
22.22Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
22.22Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
22.22Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
22.22Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
22.22Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
22.22Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
22.22Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
22.22Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
22.22Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
22.22Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
22.22Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
22.22Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
22.22Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
22.22Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
22.22Single8XVLZibotentan8XVL-ETA-Zibotentan
22.22Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
22.22Single9BJKNaloxone9BJK-μ-Naloxone-NAM
22.22Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
22.22Consensusa2_onOrthosteric Liganda2b_on
22.22Consensusa2_on_gpOrthosteric Liganda2b_on_gp
22.22Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
22.22Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
22.22Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
22.22Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
22.22Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
22.22Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
22.22Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
22.22Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
22.22Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
22.22Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
22.22Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
22.22Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
22.22Consensusrelaxin_onOrthosteric Ligandrxfp4_on
22.22Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
22.22Consensusvip-pacap_onOrthosteric Ligandvpac_on pac_on
22.22Consensusvip-pacap_on_gpOrthosteric Ligandvpac_on_gp pac_on_gp
21.88Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
21.88Single8W8YGamma-MSH8W8Y-MC3-γ-MSH-Ca-Gs/β1/γ2
21.88Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
21.88Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
21.74Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
21.74Single7SRQLSD7SRQ-5-HT2B-LSD
21.74Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
21.74Single7XP6Strychnine7XP6-TAS2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
21.74Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
21.74Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
21.74Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
21.74Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
21.74Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
21.74Single8K5BNiacin8K5B-HCA2-Niacin
21.74Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab
21.74Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
21.74Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
21.74Single9B9Y7DY9B9Y-CB1-7DY
21.74Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
21.74Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
21.74Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
21.74Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
21.74Consensusgq_nucleotideOrthosteric Ligandgq_p2y
21.74Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
21.43Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
21.43Single4AMIBucindolol4AMI-β1-Bucindolol
21.43Single4N4WSANT-14N4W-SMO-SANT-1
21.43Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
21.43Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
21.43Single5TZYMK8666; AP85TZY-FFA1-MK8666; AP8
21.43Single5X33BIIL2605X33-BLT1-BIIL260
21.43Single6CM4Risperidone6CM4-D2-Risperidone
21.43Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
21.43Single6ZG4HTL00099366ZG4-M1-HTL0009936
21.43Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
21.43Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
21.43Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
21.43Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
21.43Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
21.43Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
21.43Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
21.43Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
21.43Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
21.43Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
21.43Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
21.43Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.43Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
21.43Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
21.43Single8XYIVUF106618XYI-CXCR3-VUF10661
21.43Single8Y6WTUG-13758Y6W-FFA2-TUG-1375-4-CMTB-Gi1/β1/γ2
21.43Single9BJKNAM9BJK-μ-Naloxone-NAM
21.43Single9EBIPiclidenoson9EBI-A3A-Piclidenoson-chim(NtGi1L-Gs-CtGi1)/β1/γ2
21.43Single9GL2Befiradol9GL2-5-HT1A-Befiradol-Gs/β1/γ2
21.43Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
21.43Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
21.43Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
21.43Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
21.21Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
21.21Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
21.21Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ2
21.05Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
21.05Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
21.05Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
21.05Consensusglp1_onOrthosteric Ligand7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
20.83Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
20.83Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
20.83Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
20.83Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
20.83Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
20.83Single6B73MP11046B73-κ-MP1104
20.83Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
20.83Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
20.83Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
20.83Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
20.83Single6TODEMPA6TOD-OX1-EMPA-Na
20.83Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
20.83Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
20.83Single7F8ULintitript7F8U-CCKA-Lintitript
20.83Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
20.83Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
20.83Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
20.83Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.83Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
20.83Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
20.83Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
20.83Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.83Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
20.83Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
20.83Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
20.83Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
20.83Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
20.83Single8Y0HVUF114188Y0H-CXCR3-VUF11418
20.83Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go/β1/γ2
20.83Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
20.83Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
20.83Single9EBHAdenosine9EBH-A3A-Adenosine-Gi1/β1/γ2
20.83Single9EEAAdenosine9EEA-A2A-Adenosine-Gs/β1/γ2
20.83Single9K6LSA09K6L-TAS2R16-SA0-Gi2/β1/γ2
20.83Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
20.83Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
20.83Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.83Consensusalpha2_offOrthosteric Ligandalpha2c_off
20.69Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
20.69Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
20.69Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
20.69Single6H7LDobutamine6H7L-β1-Dobutamine
20.69Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
20.69Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
20.69Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
20.69Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
20.69Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
20.69Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
20.69Single7UM4AS26747237UM4-5-HT5A-AS2674723
20.69Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
20.69Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
20.69Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
20.69Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
20.69Single8S2TIsoprenaline8S2T-β1-Isoprenaline-chim(NtGi1-Gs)/β1/γ2
20.69Single8T3OTUG-8918T3O-FFA4-TUG-891-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.69Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
20.69Single9AS02-bromo-LSD9AS0-5-HT2A-2-bromo-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
20.69Single9C0KExendin-49C0K-GLP-1-Exendin-4-Gs/β1/γ2
20.69Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
20.69Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
20.69Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
20.69Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
20.69Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
20.69Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
20.59Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
20.59Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
20.59Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
20.59Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
20.59Consensusvpac_onOrthosteric Ligandvpac1_on vpac2_on
20.51Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
20.51Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
20.51Consensusglp1_on_gpOrthosteric Ligand7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
20.45Consensuspth_on_gpOrthosteric Ligandpth1_on_gp pth2_on_gp
20.00Single2YDOAdenosine2YDO-A2A-Adenosine
20.00Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
20.00Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
20.00Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
20.00Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
20.00Single5IU7Q274563465IU7-A2A-Q27456346-Na
20.00Single5JTBZM-2413855JTB-A2A-ZM-241385
20.00Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
20.00Single5UVIZM-2413855UVI-A2A-ZM-241385
20.00Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
20.00Single6KUXRS-799486KUX-α2a-RS-79948
20.00Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
20.00Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
20.00Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
20.00Single6PS0S-Carazolol6PS0-β2-S-Carazolol
20.00Single6PS4ICI118-5516PS4-β2-ICI118-551
20.00Single6PS5S-Propranolol6PS5-β2-S-Propranolol
20.00Single6PT3DPI-2876PT3-δ-DPI-287
20.00Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
20.00Single6TPNHTL66416TPN-OX2-HTL6641
20.00Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
20.00Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
20.00Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
20.00Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
20.00Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
20.00Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
20.00Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
20.00Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
20.00Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
20.00Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
20.00Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
20.00Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
20.00Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Single7UL3Famotidine7UL3-H2-Famotidine
20.00Single7UTZDPPC7UTZ-TSH-TR1402-DPPC-Gs/β1/γ2
20.00Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
20.00Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
20.00Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
20.00Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
20.00Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
20.00Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
20.00Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
20.00Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
20.00Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
20.00Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
20.00Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
20.00Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
20.00Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
20.00Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
20.00Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
20.00Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
20.00Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
20.00Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
20.00Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
20.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
20.00Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
20.00Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
20.00Single9AS5Mescaline9AS5-5-HT2A-Mescaline
20.00Single9AS6Mescaline9AS6-5-HT2A-Mescaline-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single9BLWCagrilintide backbone (non-acylated)9BLW-CT (AMY1)-Cagrilintide backbone (non-acylated)-Gs/β1/γ2; RAMP1
20.00Single9CGKC5-Quino9CGK-δ-C5-Quino-Gi1/β1/γ2
20.00Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
20.00Single9IXXLTD49IXX-CysLT2-LTD4-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
20.00Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
20.00Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Gi1/β1/γ2
20.00Single9NS9TUG-13759NS9-FFA2-TUG-1375-Compound 187-Gi1/β1/γ2
20.00Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
20.00Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
20.00Consensusa2_offOrthosteric Liganda2a_off
20.00Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
20.00Consensusalpha1_onOrthosteric Ligandalpha1a_on
20.00Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
20.00Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
20.00Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
20.00Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
20.00Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
20.00Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
20.00Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
20.00Consensusglucagon_onOrthosteric Ligandglp_on gluc_on secretin_on gip_on
20.00Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
20.00Consensuspac1_onOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
20.00Consensuspac1_on_gpOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
20.00Consensusvpac_on_gpOrthosteric Ligandvpac1_on_gp vpac2_on_gp
19.44Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
19.44Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
19.44Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
19.44Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
19.44Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
19.44Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
19.44Single9BUCCagrilintide9BUC-CT-Cagrilintide-Gs/β1/γ2
19.44Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
19.35Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
19.35Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
19.35Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
19.35Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
19.35Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
19.35Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
19.35Single8PKMBefiradol8PKM-5-HT1A-Befiradol-Gi1/β1/γ1
19.35Single8YWFRetatrutide8YWF-GLP-1-Retatrutide-chim(NtGi1-Gs)/β1/γ2
19.35Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
19.35Single9M4TSilodosin9M4T-Alpha1A-Silodosin
19.23Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
19.23Single2Y01Dobutamine2Y01-β1-Dobutamine
19.23Single2Y04Salbutamol2Y04-β1-Salbutamol
19.23Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
19.23Single3NY8ICI118-5513NY8-β2-ICI118-551
19.23Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
19.23Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
19.23Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
19.23Single4EJ4Naltrindole4EJ4-δ-Naltrindole
19.23Single4GBRS-Carazolol4GBR-β2-S-Carazolol
19.23Single5DHGC-355DHG-NOP-C-35
19.23Single5DHHSB-6121115DHH-NOP-SB-612111
19.23Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
19.23Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
19.23Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/β1/γ2
19.23Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
19.23Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
19.23Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
19.23Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
19.23Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
19.23Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
19.23Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
19.23Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
19.23Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
19.23Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
19.23Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
19.23Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
19.23Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
19.23Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
19.23Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
19.23Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
19.23Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
19.23Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
19.23Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
19.23Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.23Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.23Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.23Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.23Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.23Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.23Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.23Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.23Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.23Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.23Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
19.23Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
19.23Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
19.23Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
19.23Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
19.23Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
19.23Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
19.23Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
19.23Single8JJOAlprenolol8JJO-β2-Alprenolol
19.23Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
19.23Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
19.23Single8JXRLSD8JXR-D1-LSD
19.23Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
19.23Single8PJKST1718PJK-5-HT1A-ST171-Gi1/β1/γ1
19.23Single8T1WCVN4248T1W-GPR6-CVN424
19.23Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
19.23Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.23Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.23Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.23Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.23Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
19.23Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
19.23Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
19.23Single8X63Mepyramine8X63-H1-Mepyramine
19.23Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
19.23Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
19.23Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
19.23Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
19.23Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
19.23Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
19.23Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
19.23Single9PLNN-(5-methylnaphthalen-1-yl)pyridin-4-amine9PLN-α2a-N-(5-methylnaphthalen-1-yl)pyridin-4-amine
19.23Single9PLON-(5-methylnaphthalen-1-yl)pyridin-4-amine9PLO-α2a-N-(5-methylnaphthalen-1-yl)pyridin-4-amine-Go/β1/γ2
19.23Single9PQD(6m)-1-methyl-6-(1,2,5,6-tetrahydropyridin-3-yl)-1h-indole9PQD-α2a-(6m)-1-methyl-6-(1,2,5,6-tetrahydropyridin-3-yl)-1h-indole
19.23Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
19.23Consensus5ht5_onOrthosteric Ligand5ht5a_on
19.23Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
19.23Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
19.23Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
19.23Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
19.23Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
19.23Consensusalpha2_onOrthosteric Ligandalpha2b_on
19.23Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
19.23Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
19.23Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
19.23Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
19.23Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
19.23Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
19.23Consensusblt_onOrthosteric Ligandblt1_on
19.23Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
19.23Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
19.23Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
19.23Consensusdopamine_offOrthosteric Ligandd2_off d3_off
19.23Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
19.23Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
19.23Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
19.23Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
19.23Consensushistamine_offOrthosteric Ligandh1_off
19.23Consensusleukotriene_onOrthosteric Ligandblt_on
19.23Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
19.23Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
19.05Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
19.05Single7V68LY21196207V68-M4-Iperoxo-LY2119620-Gi1/β1/γ2
19.05Single7WC4Serotonin7WC4-5-HT2A-Serotonin
19.05Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
19.05Single8PWNTheophylline8PWN-A2A-Theophylline
18.92Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
18.92Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
18.92Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
18.92Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
18.92Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
18.92Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
18.92Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
18.92Consensusvpac2_on_gpOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
18.75Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
18.75Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
18.75Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
18.60Consensusclass-b1_onOrthosteric Ligandglucagon_on vip-pacap_on pth_on crf_on calcitonin_on
18.60Consensuspth2_on_gpOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
18.52Single2RH1S-Carazolol2RH1-β2-S-Carazolol
18.52Single2Y00Dobutamine2Y00-β1-Dobutamine
18.52Single2Y03Isoprenaline2Y03-β1-Isoprenaline
18.52Single2YCWS-Carazolol2YCW-β1-S-Carazolol
18.52Single4JKVTaladegib4JKV-SMO-Taladegib
18.52Single4NTJAZD12834NTJ-P2Y12-AZD1283
18.52Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
18.52Single5D6LS-Carazolol5D6L-β2-S-Carazolol
18.52Single5JQHS-Carazolol5JQH-β2-S-Carazolol
18.52Single5T1ABMS-6815T1A-CCR2-BMS-681-PubChem 12093170
18.52Single5TVNLSD5TVN-5-HT2B-LSD
18.52Single5X7DS-Carazolol5X7D-β2-S-Carazolol-Cmpd-15
18.52Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
18.52Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
18.52Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
18.52Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
18.52Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
18.52Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
18.52Single6PS6Timolol6PS6-β2-Timolol
18.52Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
18.52Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
18.52Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
18.52Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
18.52Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
18.52Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
18.52Single7SINNPS-21437SIN-CaS-NPS-2143
18.52Single7SINNPS-21437SIN-CaS-NPS-2143
18.52Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
18.52Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
18.52Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
18.52Single7WC6LSD7WC6-5-HT2A-LSD
18.52Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
18.52Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
18.52Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
18.52Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
18.52Single8GNEKW-63568GNE-A2A-KW-6356-Na
18.52Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
18.52Single8XYKVUF106618XYK-CXCR3-VUF10661-Go/β1/γ2
18.52Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
18.52Single9ARZ2-bromo-LSD9ARZ-5-HT2A-2-bromo-LSD
18.52Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
18.52Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
18.52Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
18.52Single9K07DSO-5a9K07-BB3-DSO-5a-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.52Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
18.52Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
18.52Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
18.52Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
18.52Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
18.52Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
18.52Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
18.52Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
18.52Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
18.52Consensusamine_offonOrthosteric Ligandamine_off amine_on
18.52Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
18.52Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
18.52Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
18.52Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
18.52Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
18.52Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
18.52Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
18.52Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
18.52Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
18.52Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
18.52Consensustrace-amine_onOrthosteric Ligandta1_on
18.42Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
18.42Consensusgip_onOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
18.42Consensusgip_on_gpOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
18.18Single3OE8IT1t3OE8-CXCR4-IT1t
18.18Single3RFMCaffeine3RFM-A2A-Caffeine
18.18Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
18.18Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
18.18Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
18.18Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
18.18Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.18Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
18.18Single9CHUNoradrenaline9CHU-β2-Noradrenaline
18.18Consensusclass-b1_class-b2_cons_onOrthosteric Ligandclass-b1_on class-b2_on
18.18Consensusclass-b1_class-b2_cons_on_gpOrthosteric Ligandclass-b1_on_gp class-b2_on_gp
18.18Consensusp2y_offOrthosteric Ligandp2y1_off
17.95Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
17.95Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
17.86Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
17.86Single5D5AS-Carazolol5D5A-β2-S-Carazolol
17.86Single5D5BS-Carazolol5D5B-β2-S-Carazolol
17.86Single5V57TC1145V57-SMO-TC114
17.86Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
17.86Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
17.86Single7T9NDPPC7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
17.86Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
17.86Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
17.86Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
17.86Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
17.86Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
17.86Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
17.86Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
17.86Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
17.86Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
17.86Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
17.86Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
17.86Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
17.86Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
17.86Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
17.86Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
17.86Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
17.86Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
17.86Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
17.86Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
17.86Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.86Consensustachykinin_offOrthosteric Ligandnk1_off
17.86Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
17.65Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
17.65Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
17.65Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
17.65Single9EBOGLP-1 (ACPC18)9EBO-GLP-1-GLP-1 (ACPC18)-Gs/β1/γ2
17.50Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
17.50Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
17.50Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
17.50Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
17.39Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
17.39Single4XNWMRS25004XNW-P2Y1-MRS2500
17.39Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
17.39Single6ME5Agomelatine6ME5-MT1-Agomelatine
17.39Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
17.39Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
17.39Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
17.39Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
17.39Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
17.39Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
17.39Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
17.39Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
17.39Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
17.39Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
17.39Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
17.39Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
17.39Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
17.39Single9JHJC18:0 Ceramide9JHJ-FPR2-ALX-C18:0 Ceramide-Gi1/β1/γ2
17.39Single9LRCHistamine9LRC-H4-Histamine
17.39Single9LREHistamine9LRE-H4-Histamine-Gi1/β1/γ2
17.39Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
17.39Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
17.39Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
17.39Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
17.39Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
17.24Single3D4STimolol3D4S-β2-Timolol
17.24Single4PY02MeSATP4PY0-P2Y12-2MeSATP
17.24Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
17.24Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
17.24Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
17.24Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
17.24Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
17.24Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
17.24Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
17.24Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
17.24Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
17.24Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.24Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
17.24Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
17.24Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
17.24Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
17.24Single9CM3TUG-13759CM3-FFA2-TUG-1375-Compound 187-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.24Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
17.24Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
17.24Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
17.24Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
17.24Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
17.24Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
17.24Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
17.14Consensusvpac1_onOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
17.07Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
17.02Consensusclass-b1_on_gpOrthosteric Ligandglucagon_on_gp vip-pacap_on_gp pth_on_gp crf_on_gp calcitonin_on_gp
16.67Single3PBLEticlopride3PBL-D3-Eticlopride
16.67Single4O9RCyclopamine4O9R-SMO-Cyclopamine
16.67Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
16.67Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
16.67Single6HLLCP999946HLL-NK1-CP99994
16.67Single6K1QIRL25006K1Q-ETB-IRL2500
16.67Single6LI0C176LI0-GPR52-C17
16.67Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
16.67Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
16.67Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
16.67Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
16.67Single6TP4ACT-4622066TP4-OX1-ACT-462206
16.67Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
16.67Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
16.67Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
16.67Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
16.67Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
16.67Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
16.67Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
16.67Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
16.67Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
16.67Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8HSCFab0468HSC-GPR20-Fab046-Gi1/β1/γ2
16.67Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
16.67Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
16.67Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
16.67Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
16.67Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
16.67Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
16.67Single8YN7Immethridine8YN7-H3-Immethridine-Go/β1/γ2
16.67Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
16.67Single9BP3Cagrilintide9BP3-CT (AMY1)-Cagrilintide-Gs/β1/γ2; RAMP1
16.67Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
16.67Single9CGJC6-Quino9CGJ-δ-C6-Quino-Gi1/β1/γ2
16.67Single9DYEBuspirone9DYE-5-HT1A-Buspirone-Go/β1/γ2
16.67Single9E7RGB889E7R-PAR2-GB88-chim(NtGi1L-Gs-CtGq)/β1/γ2
16.67Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
16.67Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
16.67Single9IXJHistamine9IXJ-H2-Histamine-Gs/β1/γ2
16.67Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
16.67Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
16.67Consensusfp-alpha_onOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Consensussecretin_onOrthosteric Ligand7D3S-Secretin-Secretin-Gs/β1/γ2
16.67Consensusvpac1_on_gpOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
16.22Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
16.22Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
16.22Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
16.22Consensussecretin_on_gpOrthosteric Ligand7D3S-Secretin-Secretin-Gs/β1/γ2
16.13Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
16.13Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
16.13Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
16.13Single9CM7TUG-13759CM7-FFA2-TUG-1375-AZ-1729-Gi1/β1/γ2
16.13Single9JF4PD1683689JF4-BB1-PD168368
16.13Single9JH6C20:0 Ceramide9JH6-CysLT2-C20:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
16.13Single9MD1Buspirone9MD1-5-HT1A-Buspirone-Gz/β1/γ2
16.00Single4QINSAG1.54QIN-SMO-SAG1.5
16.00Single5U09Taranabant5U09-CB1-Taranabant
16.00Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
16.00Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
16.00Single6ME9Ramelteon6ME9-MT2-Ramelteon
16.00Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
16.00Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
16.00Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
16.00Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
16.00Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
16.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
16.00Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
16.00Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
16.00Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
16.00Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
16.00Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
16.00Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
16.00Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
16.00Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
16.00Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
16.00Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.00Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
16.00Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.00Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
16.00Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
16.00Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
16.00Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
16.00Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
16.00Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
16.00Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
16.00Single8IWESpermidine8IWE-TA9-Spermidine
16.00Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
16.00Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.00Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
16.00Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
16.00Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
16.00Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.00Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.00Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.00Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
16.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
16.00Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ2
16.00Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
16.00Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
16.00Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
16.00Single9H2XA1IR19H2X-A2A-A1IR1-Na
16.00Single9LRBHistamine9LRB-H1-Histamine-Gs/β1/γ2
16.00Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
16.00Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
16.00Consensusangiotensin_offOrthosteric Ligandat1_off
16.00Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
16.00Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
16.00Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
16.00Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
16.00Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
16.00Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
16.00Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
16.00Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
16.00Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
15.79Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
15.62Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
15.62Single7QA8Peptide7QA8-STE2-Peptide
15.62Single7QA8Peptide7QA8-STE2-Peptide
15.62Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
15.62Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
15.62Single9BUECagrilintide9BUE-CT-Cagrilintide-Gs/β1/γ2
15.38Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
15.38Single3RZECidoxepin3RZE-H1-Cidoxepin
15.38Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
15.38Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
15.38Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
15.38Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
15.38Single6TPKRetosiban6TPK-OT-Retosiban
15.38Single6VI4JDTic6VI4-κ-JDTic
15.38Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
15.38Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
15.38Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
15.38Single6ZG9GSK10347026ZG9-M1-GSK1034702
15.38Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
15.38Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
15.38Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
15.38Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
15.38Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
15.38Single7RBTTirzepatide7RBT-GIP-Tirzepatide-LSN3556672-chim(NtGi1-Gs)/β1/γ2
15.38Single7T94Acetylcholine7T94-M2-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
15.38Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
15.38Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
15.38Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
15.38Single7VV6C48/807VV6-MRGPRX2-C48/80
15.38Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
15.38Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
15.38Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
15.38Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
15.38Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
15.38Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
15.38Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
15.38Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
15.38Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
15.38Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.38Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.38Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
15.38Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
15.38Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
15.38Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.38Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
15.38Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.38Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
15.38Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
15.38Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.38Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.38Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.38Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
15.38Single8YRGFospropofol8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Single9ARXSerotonin9ARX-5-HT2A-Serotonin
15.38Single9AS3LSD9AS3-5-HT2A-LSD
15.38Single9AS4LSD9AS4-5-HT2A-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
15.38Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
15.38Single9LRDHistamine9LRD-H1-Histamine-Gi1/β1/γ2
15.38Consensusopsins_offOrthosteric Ligandrhodopsin_off
15.38Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
15.38Consensussensory_offOrthosteric Ligandopsins_off
15.38Consensusvasop-oxy_offOrthosteric Ligandot_off
15.15Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
15.15Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
15.00Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
14.81Single4DAJTiotropium4DAJ-M3-Tiotropium
14.81Single4MQSIperoxo4MQS-M2-Iperoxo
14.81Single4QKX35V4QKX-β2-35V
14.81Single4U14Tiotropium4U14-M3-Tiotropium
14.81Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
14.81Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
14.81Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
14.81Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
14.81Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
14.81Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
14.81Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
14.81Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
14.81Single6H7MSalbutamol6H7M-β1-Salbutamol
14.81Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
14.81Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
14.81Single7F83PF-051904577F83-Ghrelin-PF-05190457
14.81Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
14.81Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
14.81Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
14.81Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
14.81Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
14.81Single7WC7Lisuride7WC7-5-HT2A-Lisuride
14.81Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
14.81Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
14.81Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
14.81Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
14.81Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
14.81Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
14.81Single8X64Desloratadine8X64-H1-Desloratadine
14.81Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
14.81Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
14.81Single8YN8Proxyfan8YN8-H3-Proxyfan-Go/β1/γ2
14.81Single9AS1DMT9AS1-5-HT2A-DMT
14.81Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
14.81Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
14.81Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
14.81Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
14.81Single9IYAONO-97105319IYA-GPR55-ONO-9710531
14.81Single9JEAAtropine9JEA-M1-Atropine
14.81Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
14.81Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
14.81Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
14.81Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
14.81Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
14.81Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
14.81Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
14.81Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
14.71Single9B5YLong-Acting PTH9B5Y-PTH1-Long-Acting PTH-chim(NtGi1-Gq)/β1/γ2
14.29Single5MZPCaffeine5MZP-A2A-Caffeine-Na
14.29Single5WIUNemonapride5WIU-D4-Nemonapride
14.29Single5WIVNemonapride5WIV-D4-Nemonapride-Na
14.29Single6HLPNetupitant6HLP-NK1-Netupitant
14.29Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
14.29Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
14.29Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
14.29Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
14.29Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
14.29Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
14.29Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
14.29Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
14.29Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
14.29Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
14.29Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
14.29Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single9ARYSerotonin9ARY-5-HT2A-Serotonin-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single9BLCCagrilintide backbone (non-acylated)9BLC-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
14.29Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
14.29Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
14.29Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
14.29Consensusadgrg2_onOrthosteric Ligand7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
14.29Consensusadgrg2_on_gpOrthosteric Ligand7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
14.29Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
14.29Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
14.29Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
14.29Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.95Consensusgluc_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
13.89Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
13.89Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
13.89Consensuscalcitonin_onOrthosteric Ligandctlike_on
13.79Single4U15Tiotropium4U15-M3-Tiotropium
13.79Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
13.79Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
13.79Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
13.79Single6OL9Tiotropium6OL9-M5-Tiotropium
13.79Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
13.79Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
13.79Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
13.79Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
13.79Single8EA0Iperoxo8EA0-M3-Iperoxo
13.79Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
13.79Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
13.79Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
13.79Single8ZW0PGD28ZW0-DP1-PGD2-Gs/β1/γ2
13.79Single9CLWTUG-13759CLW-FFA2-TUG-1375-4-CMTB-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.79Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
13.79Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
13.79Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
13.79Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
13.79Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
13.79Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
13.79Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
13.64Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
13.64Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
13.64Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
13.64Consensusgluc_on_gpOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
13.51Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
13.51Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
13.51Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
13.51Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
13.51Single9BLBCagrilintide backbone (non-acylated)9BLB-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
13.51Consensuscalcitonin_on_gpOrthosteric Ligandctlike_on_gp
13.51Consensuscrf2_on_gpOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
13.33Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
13.33Single5CXVTiotropium5CXV-M1-Tiotropium
13.33Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
13.33Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
13.33Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
13.33Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
13.33Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
13.33Single8JD3JNJ-404118138JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
13.33Single9GGGI-BOP9GGG-TXA2-I-BOP-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.33Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
13.16Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
13.16Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
13.16Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
13.16Consensusglp2_on_gpOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
13.04Single6TQ9SB-4081246TQ9-OX1-SB-408124
13.04Single6XBM5LWE6XBM-SMO-5LWE-Gi1/β1/γ2
13.04Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
13.04Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
13.04Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
13.04Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
13.04Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Gi1/β1/γ2
13.04Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
13.04Single9EE9Adenosine9EE9-A2A-Adenosine-Gs/β1/γ2
13.04Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
13.04Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
12.90Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
12.90Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
12.90Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
12.90Single8XVJMacitentan8XVJ-ETA-Macitentan
12.90Single9GG5U466199GG5-TXA2-U46619-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.90Single9M1HProstaglandin E29M1H-EP1-Prostaglandin E2-chim(NtGi1-Gs-CtGq)/β1/γ2
12.82Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
12.82Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
12.82Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
12.82Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
12.82Single9BQ3Cagrilintide9BQ3-CT (AMY2)-Cagrilintide-Gs/β1/γ2; RAMP2
12.82Consensuspth1_onOrthosteric Ligand6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
12.77Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
12.50Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
12.50Single3UZAGTPL92363UZA-A2A-GTPL9236
12.50Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
12.50Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
12.50Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
12.50Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
12.50Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
12.50Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
12.50Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
12.50Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
12.50Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
12.50Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
12.50Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
12.50Consensuscrf1_onOrthosteric Ligand6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF1-Corticoliberin-Gs/β1/γ2
12.50Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
12.20Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
12.12Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.00Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
12.00Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
12.00Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
12.00Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
12.00Single5L7IVismodegib5L7I-SMO-Vismodegib
12.00Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
12.00Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
12.00Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
12.00Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
12.00Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
12.00Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
12.00Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
12.00Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.00Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
12.00Single7UL2SR486927UL2-NTS1-SR48692-Na
12.00Single7V68Iperoxo7V68-M4-Iperoxo-LY2119620-Gi1/β1/γ2
12.00Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
12.00Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
12.00Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
12.00Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
12.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
12.00Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
12.00Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
12.00Single9AS2DMT9AS2-5-HT2A-DMT-chim(NtGi1-Gs-CtGq)/β1/γ2
12.00Single9AS7Psilocin9AS7-5-HT2A-Psilocin
12.00Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg4_on
12.00Consensusadgrg_on_gpOrthosteric Ligandadgrg2_on_gp adgrg4_on_gp
12.00Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
12.00Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
12.00Consensusneurotensin_offOrthosteric Ligandnts1_off
12.00Consensusnts1_offOrthosteric Ligand7UL2-NTS1-SR48692-Na
11.90Consensuscrf1_on_gpOrthosteric Ligand6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF1-Corticoliberin-Gs/β1/γ2
11.90Consensuspth1_on_gpOrthosteric Ligand6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
11.63Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
11.54Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
11.54Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
11.54Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
11.54Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
11.54Single6ME2Ramelteon6ME2-MT1-Ramelteon
11.54Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
11.54Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
11.54Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
11.54Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
11.54Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
11.54Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
11.54Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
11.54Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
11.54Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.54Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
11.54Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
11.54Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
11.54Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
11.11Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
11.11Single6A94Zotepine6A94-5-HT2A-Zotepine
11.11Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
11.11Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
11.11Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
11.11Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
11.11Single7VODCariprazine7VOD-5-HT2A-Cariprazine
11.11Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
11.11Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
11.11Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
11.11Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.11Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
11.11Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
11.11Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
11.11Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
11.11Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
11.11Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
11.11Single9BUDCagrilintide9BUD-CT-Cagrilintide-Gs/β1/γ2
11.11Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
10.81Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
10.81Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
10.71Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
10.71Single5DSGTiotropium5DSG-M4-Tiotropium
10.71Single6IIVDaltroban6IIV-TXA2-Daltroban
10.71Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.71Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
10.71Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
10.53Single9BUBCagrilintide9BUB-CT-Cagrilintide-Gs/β1/γ2
10.34Single5CGCHTL142425CGC-mGlu5-HTL14242
10.34Single6LUQHaloperidol6LUQ-D2-Haloperidol
10.34Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
10.34Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
10.34Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
10.34Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
10.34Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
10.34Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
10.34Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
10.34Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
10.34Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
10.34Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
10.34Single8ZMFA1L108ZMF-5-HT2C-A1L10
10.34Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
10.34Single9DYDAsenapine9DYD-5-HT1A-Asenapine-Go/β1/γ2
10.34Single9DYFAsenapine9DYF-5-HT1A-Asenapine-Gi1/β1/γ2
10.26Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
10.00Single5V54Methiothepin5V54-5-HT1B-Methiothepin
10.00Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
10.00Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
10.00Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
10.00Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
10.00Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
10.00Single9AS9RS130-1809AS9-5-HT2A-RS130-180
10.00Single9ASARS130-1809ASA-5-HT2A-RS130-180-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Single9BTWCagrilintide9BTW-CT (AMY3)-Cagrilintide-Gs/β1/γ2; RAMP3
10.00Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
10.00Consensus5ht1_offOrthosteric Ligand5ht1b_off
10.00Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
9.68Single6IIURamatroban6IIU-TXA2-Ramatroban
9.68Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.68Single8XJNCloprosetnol8XJN-TXA2-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
9.68Single9AU0BW245C9AU0-DP1-BW245C-Gs/β1/γ2
9.38Single5CGDHTL142425CGD-mGlu5-HTL14242
9.38Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
9.38Single8XJOU466198XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
9.38Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
9.38Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
9.38Consensustp_onOrthosteric Ligand8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
9.38Consensustp_on_gpOrthosteric Ligand8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
9.09Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
8.82Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
8.70Single3PXOAll-trans-Retinal3PXO-Rhodopsin-All-trans-Retinal
8.70Single5DYSAll-trans-Retinal5DYS-Rhodopsin-All-trans-Retinal
8.70Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
8.70Single8HS2Fab0468HS2-GPR20-Fab046
8.70Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
8.33Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
8.33Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
8.33Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
8.33Single8Y02Retinal8Y02-OPN1SW-Retinal-Gi1/β1/γ2
8.33Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
8.33Consensussensory_onOrthosteric Ligandopsins_on
8.11Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
8.00Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
8.00Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
8.00Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
8.00Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
8.00Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
8.00Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
8.00Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
8.00Single8JPSCCL78JPS-ACKR1-CCL7
8.00Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
8.00Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
8.00Consensusgi_sensoryOrthosteric Ligandgi_opsins
8.00Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
8.00Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
8.00Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
8.00Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
8.00Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
7.69Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
7.69Single8ZYUNeurotensin peptide 8-138ZYU-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
7.69Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
7.69Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
7.41Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
7.41Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
7.41Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
7.32Consensusctlike_on_gpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
7.14Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
6.90Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
6.67Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
6.67Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
6.67Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
6.67Single8ZVZBW245C8ZVZ-DP1-BW245C-Gs/β1/γ2
6.67Single9HC04YI9HC0-mGlu5-4YI
6.45Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
6.45Single7P2L4YI7P2L-mGlu5-4YI
6.45Single8JD5JNJ-40411813; ADX881788JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
6.45Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
6.45Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Gi1/β1/γ1
6.06Single9JH5C16:0 Ceramide9JH5-CysLT2-C16:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
5.00Single6D35Cholesterol6D35-SMO-Cholesterol
5.00Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
5.00Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
5.00Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
5.00Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
5.00Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042
5.00Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042
5.00Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042
5.00Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-BHFF
5.00Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
5.00Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626
5.00Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.00Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.00Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
5.00Single7DTTCa7DTT-CaS-Ca-Ca
5.00Single7DTTCa7DTT-CaS-Ca-Ca
5.00Single7DTUTryptophan7DTU-CaS-Tryptophan
5.00Single7DTUTryptophan7DTU-CaS-Tryptophan
5.00Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
5.00Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
5.00Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
5.00Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
5.00Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.00Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.00Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.00Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.00Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
5.00Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
5.00Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
5.00Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
5.00Single7EB2Baclofen7EB2-GABAB2; GABAB1-Baclofen-rac-BHFF-Gi1/β1/γ2
5.00Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
5.00Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
5.00Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
5.00Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
5.00Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
5.00Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
5.00Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
5.00Single7FIIhCG7FII-LH-hCG-chim(NtGi1-Gs)/β1/γ2
5.00Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
5.00Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
5.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
5.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
5.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.00Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
5.00Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
5.00Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
5.00Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
5.00Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
5.00Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
5.00Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.00Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.00Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.00Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.00Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.00Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.00Single7T9NM22 Fab7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
5.00Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
5.00Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
5.00Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
5.00Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
5.00Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
5.00Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
5.00Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
5.00Single7XW7K1-707XW7-TSH-K1-70
5.00Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
5.00Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
5.00Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
5.00Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
5.00Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
5.00Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
5.00Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
5.00Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
5.00Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
5.00Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
5.00Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
5.00Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
5.00Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-NAM563
5.00Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
5.00Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
5.00Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
5.00Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
5.00Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
5.00Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
5.00Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
5.00Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
5.00Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
5.00Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
5.00Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
5.00Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
5.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
5.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
5.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
5.00Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
5.00Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
5.00Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
5.00Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
5.00Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
5.00Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
5.00Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
5.00Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
5.00Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
5.00Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
5.00Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
5.00Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
5.00Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
5.00Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
5.00Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
5.00Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
5.00Single8WG9(2S)-2-amino-4-phosphonobutanoic acid8WG9-mGlu4; mGlu2-(2S)-2-amino-4-phosphonobutanoic acid
5.00Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
5.00Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
5.00Single8WGCLY3792688WGC-mGlu4; mGlu2-LY379268
5.00Single8WGDWAG; WA68WGD-mGlu4; mGlu2-WAG; WA6
5.00Single8WGDWAG; WA68WGD-mGlu4; mGlu2-WAG; WA6
5.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
5.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
5.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.00Single8WVXNorrin8WVX-LGR4-Norrin
5.00Single8WVYNorrin8WVY-LGR4-Norrin
5.00Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
5.00Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
5.00Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
5.00Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
5.00Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
5.00Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
5.00Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
5.00Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
5.00Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
5.00Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
5.00Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
5.00Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
5.00Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
5.00Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
5.00Single8XUMR-spondin-28XUM-LGR4-R-spondin-2
5.00Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
5.00Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
5.00Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
5.00Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
5.00Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
5.00Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
5.00Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
5.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
5.00Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
5.00Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
5.00Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
5.00Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
5.00Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
5.00Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
5.00Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
5.00Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
5.00Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
5.00Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
5.00Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
5.00Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
5.00Single9KHHNorrin9KHH-LGR4-Norrin
5.00Single9S37NB219S37-LGR4-NB21
5.00Single9UTBSucralose9UTB-TAS1R2; TAS1R3-Sucralose
4.76Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.76Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.76Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.76Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.76Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.76Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.76Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.76Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.76Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
4.76Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
4.76Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
4.76Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
4.76Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
4.76Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
4.76Consensusclass-b2_onOrthosteric Ligandadgrg_on adgrf_on adgrl_on adgre_on adgrd_on
4.76Consensusclass-b2_on_gpOrthosteric Ligandadgrg_on_gp adgrf_on_gp adgrl_on_gp adgre_on_gp adgrd_on_gp
4.55Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
4.55Single7T9MCS-17 Antibody7T9M-TSH-CS-17 Antibody
4.55Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
4.35Single4A4MAll-trans-Retinal4A4M-Rhodopsin-All-trans-Retinal-Gt(CT)
4.35Single5EN0All-trans-Retinal5EN0-Rhodopsin-All-trans-Retinal-Gt(CT)
4.35Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
4.35Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/β1/γ2
4.35Single7UTZTR14027UTZ-TSH-TR1402-DPPC-Gs/β1/γ2
4.35Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/β1/γ2
4.35Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
4.35Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/β1/γ2
4.17Single5L7DCholesterol5L7D-SMO-Cholesterol
4.17Single7T9ITSH7T9I-TSH-TSH-Gs/β1/γ2
4.17Single8I2GGlycoprotein hormones alpha chain8I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
4.00Single7Y14Beta-Alanine7Y14-MRGPRD-β-Alanine
4.00Single9IVMLSN33188399IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
3.85Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
3.85Single7Y12Beta-Alanine7Y12-MRGPRD-β-Alanine-Gi1/β1/γ2
3.85Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
3.70Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
3.70Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
3.70Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
3.70Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
3.70Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
3.45Single6FFIMMPEP6FFI-mGlu5-MMPEP
3.45Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
3.45Single8IYXYL-3658IYX-GPR34-YL-365
3.45Single8JD6VU03647708JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
3.33Single6FFHFenobam6FFH-mGlu5-Fenobam
3.23Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
3.12Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
2.78Single8XFTR-spondin-28XFT-LGR4-R-spondin-2-ZNRF3
2.78Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-ZNRF3
2.63Single8WVUR-spondin-18WVU-LGR4-R-spondin-1-RNF43
2.63Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-ZNRF3
2.56Single8XFPR-spondin-28XFP-LGR4-R-spondin-2-ZNRF3
2.38Single8XFSR-spondin-28XFS-LGR4-R-spondin-2-ZNRF3

Consensus Members
Id Members
8HK5 8HK5-C5a1-Complement C5-Gi1/β1/γ2
7Y66 7Y66-C5a1-BM213-Gi1/β1/γ2
7Y67 7Y67-C5a1-C089 peptide-Gi1/β1/γ2
7Y64 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
Net Summary
Imin 2.37
Number of Linked Nodes 892
Number of Links 1064
Number of Hubs 158
Number of Links mediated by Hubs 624
Number of Communities 29
Number of Nodes involved in Communities 248
Number of Links involved in Communities 343
Path Summary
Number Of Nodes in MetaPath 99
Number Of Links MetaPath 98
Number of Shortest Paths 2638570
Length Of Smallest Path 3
Average Path Length 42.6887
Length of Longest Path 78
Minimum Path Strength 0.30625
Average Path Strength 5.46314
Maximum Path Strength 20.5562
Minimum Path Correlation 0.7
Average Path Correlation 0.984385
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.36986
Average % Of Corr. Nodes 31.2475
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 44.3309
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following consensuses:
IdComponents
compl-peptide_on_gpc5a1_on_gp
c3a_on_gp



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Download c5a1_on_gp.zip



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