Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
1G.s1h1.04 9.771674169
2G.S3.03 7.02722608
3G.H2.01 7.33417409
4G.H2.05 7.61167418
5G.H2.06 6.17952719
6G.H2.07 7.12278619
7G.H2.10 5.815418
8G.h2s4.01 10.6325409
9G.S4.03 5.31083457
10G.S4.07 11.76674168
11G.s4h3.03 8.02254168
12G.H3.01 10.99174169
13G.H3.09 5.70476799
14G.H3.13 8.54056696
15G.H3.17 11.8867615
16G.S5.03 6.25167459
17G.S5.05 5.01429759
18G.HG.01 7.5125466
19G.HG.03 4.56083406
20G.hgh4.02 4.346508
21G.hgh4.05 12.92406
22G.hgh4.11 4.1405
23G.hgh4.20 5.68417403
24G.H4.03 3.30667404
25G.H4.07 9.90867565
26G.H4.08 6.89333663
27G.H4.10 12.2083407
28G.H4.12 7.34889664
29G.H4.15 9.14083498
30G.h4s6.12 3.67333402
31G.S6.05 11.2333565
32G.s6h5.01 5.85067559
33G.s6h5.05 6.35067559
34G.H5.03 7.07833459
35G.H5.05 7.095834125
36G.H5.06 8.93067554
37G.H5.08 6.597786128
38G.H5.16 8.24833446
39G.H5.17 11.7492445
40G.H5.19 6.009174108
41G.H5.20 4.79083408
42G.H5.23 9.949335104
43b.1x4 2.445408
44b.h2x1 4.69083405
45b.lhb1x6 4.585834133
46b.b1x6 8.31583489
47b.l1x3 9.63133589
48b.l1x6 11.7075419
49b.b2x5 8.804507
50b.l3x1 10.2083419
51b.b4x2 4.89083408
52b.b4x6 10.4528689
53b.l4x2 13.60924224
54b.b5x2 6.04583407
55b.b5x3 5.94444689
56b.b5x5 6.644195
57b.b5x7 7.13333407
58b.l5x1 5.3785238
59b.l5x5 10.3973509
60b.b6x1 6.87583419
61b.b6x5 5.11083406
62b.l6x5 8.158334174
63b.b7x1 8.363334174
64b.l7x4 5.35167409
65b.b8x4 6.7625406
66b.l8x3 2.16167403
67b.b9x3 6.294246
68b.l9x3 7.385335149
69b.l9x6 6.19571718
70b.b10x5 5.22609
71b.l10x1 3.84417403
72b.b11x2 5.7125407
73b.l11x2 8.741674149
74b.b12x6 10.88335148
75b.b12x7 6.484269
76b.b13x7 8.71867537
77b.l13x3 7.41389639
78b.l13x6 7.295419
79b.b14x3 6.36583435
80b.b15x1 9.39539
81b.l15x1 6.6525417
82b.b16x4 9.786536
83b.b16x6 9.92389638
84b.b17x5 7.13407
85b.l17x3 9.41278619
86b.l17x6 9.77333419
87b.b18x5 5.51917405
88b.l18x1 7.125156
89b.l18x2 5.904174157
90b.b19x2 9.03067516
91b.l19x1 7.2025419
92b.l19x2 9.00467519
93b.b20x4 12.38418
94b.b20x6 8.14533516
95b.b20x7 5.9725409
96b.l20x2 9.97333409
97b.b21x2 5.065406
98b.b21x5 5.7675404
99b.b21x7 7.93133505
100b.b22x5 6.6125157
101b.l22x5 6.476675139
102b.b23x1 4.35083405
103b.b23x6 8.144507
104b.l23x1 7.90667416
105b.l24x3 5.11583405
106b.l25x3 8.402579
107b.l25x6 15.4547518
108b.l27x1 12.8711619
109b.l27x2 6.7575479
110b.b28x2 7.10583404
111b.b28x3 5.22583487
112b.b28x4 7.58583476
113b.b28x6 8.53611679
114g.l1x2 4.1175402
115g.h2x11 11.16424156
116g.ctx3 6.389335279
117g.ctx6 3.9165276
118g.ctx15 6.32417409
119g.ctx16 5.32583408
120Lig 11.68362420
121NT.V38 3.74917405
1221x39 7.8125426
1231x53 4.12667409
124I1x50 5.94167408
1252x40 6.93867508
1262x42 3.72407
1272x50 5.70267509
1282x67 2.4025403
1293x17 2.79333423
1303x36 4.81583425
1313x42 8.523335118
1323x46 4.348334109
1333x50 11.96924109
1343x54 5.67867508
1353x55 12.2792446
136I2x53 8.05833408
1374x50 8.321674119
1384x60 4.658505
1394x61 5.7125425
1405x47 10.1992407
1415x58 6.09867508
1425x64 8.168546
1435x68 11.9117448
1446x37 2.93583408
1456x44 5.53533508
1466x48 10.084527
1476x51 7.83933525
1486x54 9.29333424
1496x57 5.2525424
150E3.H270 4.68417404
151E3.F277 6.50133523
1527x34 9.23333424
1537x52 3.405408
1547x53 5.337226109
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1b.b3x6 b.l1x3 84.85813.48NoYes099
2b.b3x6 b.l3x2 84.94946.87NoNo099
3b.b4x2 b.l3x2 10.50015.53YesNo089
4b.b4x6 b.l1x3 81.08164.23333YesYes899
5b.l1x4 b.l3x2 89.596511.76NoNo069
6G.HN.51 b.l1x4 1006.58NoNo046
7G.HN.51 G.hns1.02 99.90014.95333NoNo044
81x60 I1x50 12.61866.41NoYes088
91x60 I1x49 16.58848.17333NoNo087
10I1x49 b.b28x2 17.15518.45667NoYes074
11b.b28x4 b.b28x6 14.06685.41333YesYes769
12b.b28x6 b.lhb1x11 21.82744.65333YesNo794
13b.lhb1x11 g.ctx5 22.76616.12667NoNo049
14g.ctx3 g.ctx5 22.94434.07YesNo099
15g.ctx3 g.ctx4 75.67674.29333YesNo097
16b.l26x5 g.ctx4 75.99436.15NoNo057
17b.l26x5 g.ctx15 75.67335.59NoYes059
18b.l4x2 g.ctx15 76.923714.8367YesYes049
19b.b28x2 b.l27x2 12.19674.77333YesYes049
20b.l25x3 b.l27x2 12.94937.56333YesYes799
21G.hns1.01 b.l1x4 92.71185.07667NoNo046
22G.S1.03 G.hns1.01 92.565719.8933NoNo094
23G.hns1.02 I2x54 99.849813.9133NoNo045
24G.S1.03 G.h2s4.03 92.49235.16NoNo096
25G.h2s4.03 b.l1x6 89.37299.21667NoYes169
26b.l1x6 b.l3x1 87.71959.04YesYes199
27I2x53 I2x54 99.79948.71YesNo085
283x53 I2x53 99.23168.47667NoYes098
293x53 G.H5.23 98.66655.51333NoYes1094
303x54 G.H5.23 36.5934.03333YesYes084
313x54 G.H5.16 37.97425.49YesYes086
325x68 G.H5.16 32.21611.54YesYes486
335x68 G.H5.17 32.163816.55YesYes485
34G.H5.17 G.S6.02 31.344814.7467YesNo058
35G.H5.10 G.S6.02 30.94259.96NoNo078
36G.HG.03 G.s4h3.02 22.73614.00333YesNo069
37G.HG.02 G.HG.03 24.98276.33333NoYes096
38G.HG.02 G.s6h5.02 25.13117.78NoNo098
39G.s6h5.02 G.s6h5.05 25.42724.67NoYes089
40G.H5.06 G.s6h5.05 24.32596.35667YesYes549
41G.H5.06 G.S6.04 26.023213.1667YesNo049
42G.H5.10 G.S6.04 28.160812.61NoNo079
43G.H2.10 b.l3x1 41.78539.16YesYes189
44G.H2.10 b.b6x1 41.45164.86YesYes189
45b.b6x1 b.l9x6 82.32797.18YesYes198
46b.b2x1 b.l3x1 41.503812.7767NoYes189
47b.b2x1 b.b6x1 41.390311.9733NoYes189
48G.H2.06 b.l9x6 51.09723.98YesYes198
49G.H2.06 b.l19x1 49.27865.53YesYes199
50G.HG.15 G.hgh4.02 13.06663.76667NoYes078
51G.HG.15 G.s4h3.04 20.322811.6867NoNo078
52G.HG.07 G.s4h3.04 20.62910.75NoNo098
53G.HG.07 G.s4h3.02 20.93443.57NoNo099
54G.H4.10 G.hgh4.08 10.308715.4733YesNo076
553x50 G.H5.23 65.722828.8067YesYes1094
56b.l17x5 b.l19x1 49.23355.4NoYes169
57b.b19x6 b.l17x5 23.57953.80333NoNo196
58b.b19x6 b.l17x3 23.288511.1567NoYes199
59b.b19x4 b.l17x3 42.41618.21333NoYes189
60b.b19x4 b.b20x6 41.83857.35NoYes186
61b.b17x7 b.b20x6 32.904915.36NoYes186
62b.b17x5 b.b17x7 32.37958.98YesNo078
63b.b17x5 b.b21x1 24.02456.96333YesNo077
64b.1x19 b.b21x1 22.242917.4733NoNo067
65b.1x15 b.1x19 19.24937.1NoNo076
66b.l17x5 b.l19x2 25.37133.92333NoYes169
67b.l17x3 b.l19x2 23.2979.24YesYes199
68b.1x15 g.h1x11 12.04492.37667NoNo079
69b.1x11 g.h1x11 10.23945.53667NoNo089
70b.l22x1 g.ctx3 30.32578.83NoYes099
71b.b23x1 b.l22x1 30.17754.50333YesNo059
72b.b23x1 b.lhb1x9 56.63894.28YesNo053
73b.lhb1x6 b.lhb1x9 56.00514.09333YesNo033
74b.b24x7 b.lhb1x6 27.35177.79NoYes1393
75b.b24x7 b.l24x3 27.02839.67667NoYes095
76b.h2x5 b.l24x3 25.7224.50333NoYes055
77b.h2x1 b.h2x5 50.79663.93333YesNo055
78g.ctx3 g.ctx6 30.82275.43YesYes2796
79b.b23x1 g.ctx6 30.24824.15YesYes056
80b.l22x5 b.lhb1x6 28.01885.23333YesYes1393
81b.l22x5 b.l24x2 26.05544.86YesNo1396
82b.h2x5 b.l24x2 25.7375.40667NoNo056
83b.b21x5 b.h2x1 36.16147.06667YesYes045
84b.b21x4 b.h2x1 10.06824.61333NoYes055
85b.b1x6 b.b4x6 78.308620.5YesYes899
86b.b1x6 b.b28x5 78.16574.28333YesNo095
87b.l4x2 g.ctx16 76.30875.84667YesYes048
88b.b28x5 g.ctx16 76.58774.60667NoYes058
89b.b10x1 b.l9x6 31.7633.81667NoYes098
90b.b10x1 b.b11x5 31.47064.89NoNo096
91b.b11x5 b.b14x3 26.08476.00667NoYes065
92b.b10x2 b.b14x3 23.21145.28667NoYes065
93b.b10x2 b.b6x2 18.41843.38NoNo068
94b.b10x3 b.b6x2 18.11716.76NoNo088
95b.b10x3 b.b11x2 17.81574.91NoYes087
96b.b21x5 b.b21x7 32.8369.18YesYes045
97b.b21x7 b.b23x2 15.47335.86333YesNo056
98b.b22x5 b.b23x2 12.79411.7733YesNo076
99b.b21x7 b.b24x6 14.138213.8267YesNo058
1003x36 Lig 40.74975.18YesYes250
1013x36 6x48 42.3696.20667YesYes257
1026x44 6x48 31.83795.68YesYes087
1033x43 6x44 20.0054.06NoYes088
1043x43 7x53 19.99154.3NoYes089
1053x50 7x53 39.97915.14333YesYes1099
1066x48 7x45 14.756916.1967YesNo079
1077x45 7x49 15.44967.63NoNo099
1087x49 7x53 19.07714.21667NoYes099
1095x54 6x44 23.9476.63667NoYes088
1105x54 5x58 25.33154.39NoYes088
1113x50 5x58 21.51288.91667YesYes098
1125x47 6x44 11.30536.43YesYes078
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
3x21Lig4.276672NoYes6010
2x63Lig3.890NoYes4010
2x64Lig13.93330NoYes3010
3x25Lig19.732NoYes6010
1x39Lig15.08332YesYes6010
2x60Lig12.662NoYes4010
2x61Lig7.762NoYes5010
7x38Lig5.162NoYes4010
3x29Lig26.112NoYes5010
3x32Lig6.773332NoYes5010
3x33Lig4.816672NoYes4010
3x36Lig5.182YesYes5010
4x61Lig8.603332YesYes5010
6x51Lig7.742YesYes5010
7x34Lig13.01672YesYes4010
E2.Y183Lig20.85330NoYes0010
5x40Lig14.04332NoYes4010
6x55Lig6.072NoYes5010
E3.F277Lig5.782YesYes0010
1x392x576.443332YesNo6712
1x397x386.903332YesNo6411
2x563x326.396670NoNo5521
2x573x324.386670NoNo7521
2x603x285.006672NoNo4512
2x603x296.066672NoNo4511
3x253x299.312NoNo6511
3x264x614.250NoYes4521
3x304x615.633330NoYes5521
3x334x576.892NoNo4712
3x334x614.363332NoYes4511
3x366x486.206672YesYes5712
3x367x415.343332YesNo5712
5x406x583.803332NoNo4412
5x406x593.973332NoNo4412
6x487x4110.572YesNo7722
6x516x529.646672YesNo5512
6x516x5511.36672YesNo5511
6x517x345.003332YesYes5411
6x517x415.442YesNo5712
6x546x586.626672YesNo4422
6x54E3.F27712.06672YesYes4021
6x547x3412.82332YesYes4421
6x58E3.F2775.023332NoYes4021
E3.C273E3.F2775.122NoYes0021
E3.F277E3.G2744.516672YesNo0012
7x347x386.092YesNo4411
3x173x205.666672YesNo3312
2x673x213.690YesNo3621
1x362x653.172NoNo3412
1x402x612.946672NoNo5521
1x397x352.822YesNo6412
3x17Lig2.743332YesYes3010
2x533x362.533330NoYes8521
3x173x182.303332YesNo3312
1x36Lig2.12NoYes3010
E3.P268Lig1.890NoYes0010
1x361x371.676672NoNo3512
3x21E1.A1081.052NoNo6012
3x173x190.462YesNo3212

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
95.24Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
73.91Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
72.73Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
69.23Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
62.07Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
62.07Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
60.71Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
57.14Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
54.55Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
54.55Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
54.17Single8QJ2pN1628QJ2-MC4-pN162-Gs
53.85Single6W25SHU91196W25-MC4-SHU9119-Ca
52.00Single8KIGSHU91198KIG-MC3-SHU9119-Ca
52.00Single8WKYPG-9348WKY-MC4-PG-934
50.00Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
50.00Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
50.00Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
50.00Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
48.15Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
48.15Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
48.00Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
48.00Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
48.00Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
48.00Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
47.83Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
46.67Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
46.67Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
46.67Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
46.43Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
46.15Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
46.15Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
45.83Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
45.83Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
45.83Consensusorexin_onOrthosteric Ligandox2_on
44.83Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
44.83Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
44.44Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
44.44Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
44.44Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
44.00Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
44.00Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
44.00Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
44.00Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
44.00Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
43.48Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
43.48Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
43.33Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
43.33Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
42.86Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
42.86Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
42.86Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
42.86Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
42.86Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
42.50Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
42.31Single5ZTYAM102575ZTY-CB2-AM10257
42.31Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
42.31Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
42.31Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
42.31Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
42.31Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
41.94Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
41.94Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
41.94Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
41.94Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
41.67Single5XR8AM8415XR8-CB1-AM841
41.67Single5XRAAM115425XRA-CB1-AM11542
41.67Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
41.67Single7FEECP559407FEE-CB1-CP55940-ZCZ011
41.67Single7TUYGSK682753A7TUY-GPR183-GSK682753A
41.67Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
41.67Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
41.67Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
41.67Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
41.67Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
41.38Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
41.38Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
41.38Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
41.38Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
40.74Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
40.74Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
40.74Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
40.74Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
40.74Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
40.74Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
40.74Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
40.74Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
40.74Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
40.00Single6KQICP559406KQI-CB1-CP55940-Org27569
40.00Single7YITNalfurafine7YIT-κ-Nalfurafine
40.00Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
40.00Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
40.00Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
40.00Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
40.00Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
40.00Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
40.00Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
40.00Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
40.00Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
40.00Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
40.00Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
40.00Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
39.39Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
39.39Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
39.39Consensusbombesin_onOrthosteric Ligandbb2_on
39.39Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
39.39Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
39.29Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
39.29Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
39.29Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
39.29Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
39.29Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
39.29Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
39.13Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
39.13Single7V3ZCP559407V3Z-CB1-CP55940
39.13Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
39.13Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
39.13Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
39.13Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
39.13Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
39.13Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
39.13Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
38.71Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
38.71Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
38.46Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
38.46Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
38.46Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
38.46Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
38.46Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
38.46Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
38.46Consensuscck_onOrthosteric Ligandccka_on cckb_on
38.46Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
38.46Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
38.46Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
38.46Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
38.46Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
38.46Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
38.46Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
38.46Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
37.93Single6PT2KGCHM076PT2-δ-KGCHM07
37.93Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
37.93Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
37.93Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
37.93Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
37.93Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
37.93Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
37.50Single5N2SPSB365N2S-A1-PSB36
37.50Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
37.50Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
37.50Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
37.50Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/β1/γ2
37.50Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
37.50Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
37.50Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
37.50Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
37.50Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
37.50Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
37.04Single4UG2CGS216804UG2-A2A-CGS21680
37.04Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
37.04Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
37.04Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
37.04Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
37.04Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
37.04Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
37.04Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
37.04Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
37.04Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
37.04Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
36.67Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
36.67Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
36.67Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
36.36Single6AKXA4R6AKX-CCR5-A4R
36.36Single6IGLIRL16206IGL-ETB-IRL1620
36.36Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
36.36Single7XRRLemborexant7XRR-OX2-Lemborexant
36.36Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
36.36Consensusorexin_offOrthosteric Ligandox2_off ox1_off
36.36Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
36.00Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
36.00Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
36.00Single6TQ7SB-3348676TQ7-OX1-SB-334867
36.00Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
36.00Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
36.00Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
36.00Single8E0GBU728E0G-μ-BU72
36.00Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
36.00Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
36.00Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
36.00Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
35.71Single4XT1Fractalkine4XT1-US28-Fractalkine
35.71Single7F8XNN90567F8X-CCKA-NN9056
35.71Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
35.71Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
35.71Consensuslpl_onOrthosteric Ligands1p_on lpa_on
35.71Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
35.48Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
35.48Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
35.48Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
35.48Single8ZRTET-18ZRT-ETB-ET-1
35.29Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
35.29Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
35.29Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
35.29Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
34.78Single4MBSMaraviroc4MBS-CCR5-Maraviroc
34.78Single4ZJCSB-6740424ZJC-OX1-SB-674042
34.78Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
34.78Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
34.78Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
34.78Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
34.78Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
34.78Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
34.78Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
34.78Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
34.78Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
34.78Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
34.78Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
34.78Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
34.62Single4RWADIPP-NH24RWA-δ-DIPP-NH2
34.62Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
34.62Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
34.62Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
34.62Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
34.62Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
34.62Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
34.62Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
34.62Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
34.62Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
34.62Single8JWY2-1188JWY-A2A-2-118
34.62Single8JWZAB9288JWZ-A2A-AB928-Na
34.62Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
34.62Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
34.62Single8XYIVUF106618XYI-CXCR3-VUF10661
34.62Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
34.62Consensusalpha1_offOrthosteric Ligandalpha1a_off
34.62Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
34.62Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
34.62Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
34.62Consensuslpl_offOrthosteric Ligands1p_off lpa_off
34.62Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
34.62Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
34.48Single3QAKUK-4320973QAK-A2A-UK-432097
34.48Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
34.48Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
34.48Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
34.48Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
34.48Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
34.48Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
34.48Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
34.48Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
34.48Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
34.48Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
34.48Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
34.48Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
34.48Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
34.48Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
34.38Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
34.38Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
34.38Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
34.38Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
34.38Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
33.33Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
33.33Single4YAYZD-71554YAY-AT1-ZD-7155
33.33Single5UIGCmpd-15UIG-A2A-Cmpd-1
33.33Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
33.33Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
33.33Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
33.33Single6TOTLemborexant6TOT-OX1-Lemborexant
33.33Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
33.33Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
33.33Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
33.33Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
33.33Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
33.33Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
33.33Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
33.33Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
33.33Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
33.33Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
33.33Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
33.33Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
33.33Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
33.33Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
33.33Single8CU6LJ-45178CU6-A2A-LJ-4517
33.33Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
33.33Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
33.33Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
33.33Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
33.33Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
33.33Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
33.33Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
33.33Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
33.33Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
33.33Consensusa3_onOrthosteric Liganda3a_on
33.33Consensuscck_offOrthosteric Ligandccka_off
33.33Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
33.33Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
33.33Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
33.33Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
33.33Consensusendothelin_offOrthosteric Ligandetb_off
33.33Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
33.33Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
32.26Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
32.26Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
32.26Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
32.26Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
32.26Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
32.26Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
32.26Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
32.26Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
32.26Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
32.26Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
32.26Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
32.26Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
32.14Single3NY9ICI118-5513NY9-β2-ICI118-551
32.14Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
32.14Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
32.14Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
32.14Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
32.14Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
32.14Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
32.00Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
32.00Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
32.00Single5C1MBU725C1M-μ-BU72
32.00Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
32.00Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
32.00Single5WQCEMPA5WQC-OX2-EMPA
32.00Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
32.00Single6TP6Filorexant6TP6-OX1-Filorexant
32.00Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
32.00Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
32.00Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
32.00Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
32.00Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
32.00Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
32.00Single8GNEKW-63568GNE-A2A-KW-6356-Na
32.00Single8JXSPF-61428JXS-D1-PF-6142
32.00Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
32.00Single8S4DCMF-0198S4D-Apelin-CMF-019
32.00Single8TF5Oleic acid8TF5-GPR6-Oleic acid
32.00Single8XYKVUF106618XYK-CXCR3-VUF10661-Go1/β1/γ2
32.00Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
32.00Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
32.00Consensusa3_on_gpOrthosteric Liganda3a_on_gp
32.00Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
32.00Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
32.00Consensusadenosine_offOrthosteric Liganda1_off a2_off
32.00Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
32.00Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
32.00Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
31.82Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
31.82Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
31.82Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
31.82Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
31.82Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
31.43Single6IGKEndothelin-36IGK-ETB-Endothelin-3
31.25Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
31.25Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
31.25Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
31.25Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
31.25Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
31.25Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
31.25Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
31.25Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
31.03Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
31.03Single7QA8Peptide7QA8-STE2-Peptide
31.03Single7QA8Peptide7QA8-STE2-Peptide
31.03Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
31.03Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
31.03Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
31.03Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
31.03Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
31.03Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
31.03Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
31.03Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/β1/γ2
31.03Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
31.03Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
31.03Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
31.03Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
31.03Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
31.03Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
31.03Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
30.77Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
30.77Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
30.77Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
30.77Single6E59L-7607356E59-NK1-L-760735
30.77Single6J20Aprepitant6J20-NK1-Aprepitant
30.77Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
30.77Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
30.77Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
30.77Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
30.77Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
30.77Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
30.77Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
30.77Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
30.77Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
30.77Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
30.77Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
30.77Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
30.77Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
30.77Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
30.77Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
30.77Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
30.77Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
30.77Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
30.77Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
30.77Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
30.77Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
30.77Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
30.77Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
30.77Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
30.77Consensusa2_onOrthosteric Liganda2b_on
30.77Consensusa2_on_gpOrthosteric Liganda2b_on_gp
30.77Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
30.77Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
30.77Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
30.77Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
30.77Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
30.77Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
30.77Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
30.77Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
30.77Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
30.77Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
30.77Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
30.77Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
30.77Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
30.43Single3PWHZM-2413853PWH-A2A-ZM-241385
30.43Single4S0VSuvorexant4S0V-OX2-Suvorexant
30.43Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
30.43Single5WS3EMPA5WS3-OX2-EMPA
30.43Single5ZKQABT-4915ZKQ-PAF-ABT-491
30.43Single6AKYMaraviroc6AKY-CCR5-Maraviroc
30.43Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
30.43Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
30.43Single6TODEMPA6TOD-OX1-EMPA-Na
30.43Single6TPJSuvorexant6TPJ-OX2-Suvorexant
30.43Single7F8ULintitript7F8U-CCKA-Lintitript
30.43Single7F8YDevazepide7F8Y-CCKA-Devazepide
30.43Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
30.43Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
30.43Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
30.43Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
30.43Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
30.43Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
30.43Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
30.43Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
30.43Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
30.43Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
30.43Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
30.43Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
30.43Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
30.43Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
30.43Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
30.30Single4XT3Fractalkine4XT3-US28-Fractalkine
30.30Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
30.30Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
30.30Single7SK3CXCL127SK3-ACKR3-CXCL12
30.30Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
30.30Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
30.30Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
30.00Single6HLOAprepitant6HLO-NK1-Aprepitant
30.00Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
30.00Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
30.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
30.00Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
30.00Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
30.00Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
30.00Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
30.00Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
30.00Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
29.63Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
29.63Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
29.63Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
29.63Single6ZG4HTL00099366ZG4-M1-HTL0009936
29.63Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
29.63Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
29.63Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
29.63Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
29.63Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
29.63Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
29.63Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
29.63Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
29.63Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
29.63Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
29.63Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
29.63Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
29.63Single8JJLOlodaterol8JJL-β2-Olodaterol
29.63Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
29.63Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
29.63Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
29.63Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
29.63Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
29.63Consensuslpa_offOrthosteric Ligandlpa1_off
29.63Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
29.63Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
29.41Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
29.17Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
29.17Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
29.17Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
29.17Single5IU7Q274563465IU7-A2A-Q27456346-Na
29.17Single5IUBQ274563445IUB-A2A-Q27456344-Na
29.17Single5JTBZM-2413855JTB-A2A-ZM-241385
29.17Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
29.17Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
29.17Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
29.17Single6IQLL7458706IQL-D4-L745870
29.17Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
29.17Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
29.17Single6TP3Nemorexant6TP3-OX1-Nemorexant
29.17Single6TPGEMPA6TPG-OX2-EMPA
29.17Single6TPKRetosiban6TPK-OT-Retosiban
29.17Single6TPNHTL66416TPN-OX2-HTL6641
29.17Single6V9SGTPL114036V9S-OX1-GTPL11403
29.17Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
29.17Single7AROLUF58337ARO-A2A-LUF5833-Na
29.17Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
29.17Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
29.17Single8IHKAcifran8IHK-HCA3-Acifran
29.17Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
29.17Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
29.17Single8K5CAcipimox8K5C-HCA2-Acipimox
29.17Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
29.17Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
29.17Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.17Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
29.17Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
29.17Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
29.17Consensusa2_offOrthosteric Liganda2a_off
29.17Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
29.17Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
29.17Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
29.17Consensushca_onOrthosteric Ligandhca2_on
29.17Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
29.17Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
29.17Consensusvasop-oxy_offOrthosteric Ligandot_off
29.03Single5WF5UK-4320975WF5-A2A-UK-432097
29.03Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
29.03Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
29.03Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
29.03Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
29.03Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
29.03Consensusangiotensin_onOrthosteric Ligandat1_on
29.03Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
29.03Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
29.03Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
29.03Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
28.95Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
28.57Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
28.57Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
28.57Single5X93K-87945X93-ETB-K-8794
28.57Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
28.57Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
28.57Single7EZCUKA7EZC-A2A-UKA
28.57Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
28.57Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
28.57Single7UM4AS26747237UM4-5-HT5A-AS2674723
28.57Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
28.57Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
28.57Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
28.57Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
28.57Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
28.57Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
28.57Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
28.57Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
28.57Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
28.57Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
28.57Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
28.57Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
28.57Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Consensusprostanoid_offOrthosteric Ligandep_off dp_off
28.12Single6JODAngiotensin II6JOD-AT2-Angiotensin II
28.12Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
28.12Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
28.12Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
28.12Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
28.12Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
28.12Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
28.12Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
28.12Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
28.12Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
28.12Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
28.12Consensusvasop-oxy_onOrthosteric Ligandv2_on
28.12Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
28.00Single3EMLZM-2413853EML-A2A-ZM-241385
28.00Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
28.00Single4EJ4Naltrindole4EJ4-δ-Naltrindole
28.00Single5DHGC-355DHG-NOP-C-35
28.00Single5DHHSB-6121115DHH-NOP-SB-612111
28.00Single5IU8Q274563475IU8-A2A-Q27456347-Na
28.00Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
28.00Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
28.00Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
28.00Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
28.00Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
28.00Single5UENDU1725UEN-A1-DU172
28.00Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
28.00Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
28.00Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
28.00Single6PS1Timolol6PS1-β2-Timolol
28.00Single6S0LZM-2413856S0L-A2A-ZM-241385
28.00Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
28.00Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
28.00Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
28.00Single7PYRPSB-21157PYR-A2A-PSB-2115
28.00Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
28.00Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
28.00Single7UL4Alvimopan7UL4-μ-Alvimopan
28.00Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
28.00Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
28.00Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
28.00Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
28.00Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
28.00Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
28.00Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
28.00Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
28.00Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
28.00Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
28.00Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
28.00Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
28.00Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
28.00Single8K5DGSK2560738K5D-HCA2-GSK256073
28.00Single8PJKST1718PJK-5-HT1A-ST171-t7m-Gi1/β1/γ1
28.00Single8RLNLUF58348RLN-A2A-LUF5834
28.00Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
28.00Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
28.00Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
28.00Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
28.00Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
28.00Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
28.00Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
28.00Single9CHXS-Carazolol9CHX-β2-S-Carazolol
28.00Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
28.00Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
28.00Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
28.00Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
28.00Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
28.00Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
28.00Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
28.00Consensushca_on_gpOrthosteric Ligandhca2_on_gp
27.78Single5GLHEndothelin-15GLH-ETB-Endothelin-1
27.78Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
27.78Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
27.78Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
27.59Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
27.59Single6PT3DPI-2876PT3-δ-DPI-287
27.59Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
27.59Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
27.59Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
27.59Single7SK9CCX6627SK9-ACKR3-CCX662
27.59Single7XN9L-054,5227XN9-SST2-L-054,522
27.59Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
27.59Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
27.59Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
27.59Single8X5YAstemizole8X5Y-H1-Astemizole
27.59Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
27.59Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
27.59Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
27.27Single3OE6IT1t3OE6-CXCR4-IT1t
27.27Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
27.27Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
27.27Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
27.27Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
27.27Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.27Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
27.27Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
27.27Consensus5ht2_onOrthosteric Ligand5ht2b_on
27.27Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
27.27Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
27.27Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
27.27Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
27.27Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
27.03Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
27.03Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
27.03Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
27.03Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
26.92Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
26.92Single5IUAQ274563485IUA-A2A-Q27456348-Na
26.92Single5N2RPSB-365N2R-A2A-PSB-36-Na
26.92Single5X7DS-Carazolol5X7D-β2-S-Carazolol-PubChem 129318963
26.92Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
26.92Single6D26Fevipiprant6D26-DP2-Fevipiprant
26.92Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
26.92Single6HLPNetupitant6HLP-NK1-Netupitant
26.92Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
26.92Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
26.92Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
26.92Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
26.92Single6S0QZM-2413856S0Q-A2A-ZM-241385
26.92Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
26.92Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
26.92Single7C4SS1P7C4S-S1P3-S1P
26.92Single7C61Ergotamine7C61-5-HT1B-Ergotamine
26.92Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
26.92Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
26.92Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
26.92Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
26.92Single7W41PD1762527W41-BB2-PD176252
26.92Single7WC6LSD7WC6-5-HT2A-LSD
26.92Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
26.92Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
26.92Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
26.92Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
26.92Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
26.92Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
26.92Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
26.92Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
26.92Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
26.92Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.92Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
26.92Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
26.92Single8QOTNanobody-E8QOT-μ-Nanobody-E
26.92Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
26.92Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
26.92Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.92Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.92Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
26.92Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
26.92Single8WGBW9R8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
26.92Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
26.92Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
26.92Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
26.92Single9F34FOB02-04A9F34-D3-FOB02-04A-Go1/β1/γ2
26.92Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
26.92Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
26.92Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
26.92Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
26.92Consensusbombesin_offOrthosteric Ligandbb2_off
26.92Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
26.92Consensusdp_offOrthosteric Liganddp2_off
26.92Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
26.67Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
26.67Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
26.67Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
26.67Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
26.67Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
26.67Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
26.67Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
26.67Single8IEBA1LYA8IEB-GPR156-A1LYA
26.67Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
26.67Single8PKMBefiradol8PKM-5-HT1A-Befiradol-t7m-Gi1/β1/γ1
26.67Single8WDTphotoNECA8WDT-A2A-photoNECA
26.67Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
26.67Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
26.67Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
26.67Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
26.67Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
26.67Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
26.67Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
26.67Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
26.67Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
26.47Single6FJ3PTH6FJ3-PTH1-PTH
26.47Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
26.47Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
26.47Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
26.47Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
26.47Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
26.47Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
26.47Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
26.47Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
26.32Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
26.09Single3OE9IT1t3OE9-CXCR4-IT1t
26.09Single6HLLCP999946HLL-NK1-CP99994
26.09Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
26.09Single7SRQLSD7SRQ-5-HT2B-LSD
26.09Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
26.09Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
26.09Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
26.09Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
26.09Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
26.09Single8K5BNiacin8K5B-HCA2-Niacin
26.09Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
26.09Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
26.09Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
26.09Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
26.09Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
25.93Single2YDVNECA2YDV-A2A-NECA
25.93Single3P0GBI1671073P0G-β2-BI167107
25.93Single4DJHJDTic4DJH-κ-JDTic
25.93Single4UHRCGS216804UHR-A2A-CGS21680
25.93Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
25.93Single5G53NECA5G53-A2A-NECA-Gs
25.93Single5TZRMK86665TZR-FFA1-MK8666
25.93Single6H7JIsoprenaline6H7J-β1-Isoprenaline
25.93Single6J21Aprepitant6J21-NK1-Aprepitant
25.93Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
25.93Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
25.93Single7B6WCyclazosin7B6W-α1b-Cyclazosin
25.93Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
25.93Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
25.93Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
25.93Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
25.93Single7PX4PSB-21137PX4-A2A-PSB-2113
25.93Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
25.93Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
25.93Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.93Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
25.93Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
25.93Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
25.93Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
25.93Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
25.93Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.93Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
25.93Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
25.93Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
25.93Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
25.93Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
25.93Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
25.93Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
25.93Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
25.93Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
25.93Single8XVLZibotentan8XVL-ETA-Zibotentan
25.93Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
25.93Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
25.93Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
25.93Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
25.93Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
25.93Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
25.93Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
25.93Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
25.93Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
25.93Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
25.93Consensuslpa_onOrthosteric Ligandlpa1_on
25.93Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
25.93Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
25.93Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
25.93Consensusrelaxin_onOrthosteric Ligandrxfp4_on
25.93Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
25.81Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
25.81Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
25.81Single7SK5CXCL127SK5-ACKR3-CXCL12
25.81Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
25.81Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
25.81Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
25.81Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
25.81Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
25.71Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
25.71Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
25.71Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
25.64Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
25.00Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
25.00Single3ODUIT1t3ODU-CXCR4-IT1t
25.00Single3OE0CVX153OE0-CXCR4-CVX15
25.00Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
25.00Single4LDEBI1671074LDE-β2-BI167107
25.00Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
25.00Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
25.00Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
25.00Single5TZYMK8666; PubChem 1270535975TZY-FFA1-MK8666; PubChem 127053597
25.00Single6A93Risperidone6A93-5-HT2A-Risperidone
25.00Single6B73MP11046B73-κ-MP1104
25.00Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
25.00Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
25.00Single6MXTSalmeterol6MXT-β2-Salmeterol
25.00Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
25.00Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
25.00Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
25.00Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
25.00Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
25.00Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
25.00Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
25.00Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
25.00Single7DFPSpiperone7DFP-D2-Spiperone
25.00Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
25.00Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
25.00Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
25.00Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
25.00Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
25.00Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
25.00Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
25.00Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
25.00Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
25.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
25.00Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
25.00Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
25.00Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
25.00Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
25.00Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
25.00Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
25.00Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
25.00Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
25.00Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
25.00Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
25.00Single8GNGIstradefylline8GNG-A2A-Istradefylline
25.00Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
25.00Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
25.00Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
25.00Single8IWESpermidine8IWE-TA9-Spermidine
25.00Single8IY6Endothelin-18IY6-ETB-Endothelin-1
25.00Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
25.00Single8JJ8Formoterol8JJ8-β2-Formoterol
25.00Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
25.00Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
25.00Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
25.00Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
25.00Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
25.00Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
25.00Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
25.00Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
25.00Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
25.00Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
25.00Single8Y0HVUF114188Y0H-CXCR3-VUF11418
25.00Single8ZPLHF511168ZPL-CXCR4-HF51116-Cholesterol
25.00Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
25.00Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
25.00Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
25.00Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
25.00Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
25.00Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
25.00Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
25.00Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
25.00Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
25.00Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Consensusalpha2_offOrthosteric Ligandalpha2c_off
25.00Consensusangiotensin_offOrthosteric Ligandat1_off
25.00Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
25.00Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
25.00Consensusbradykinin_onOrthosteric Ligandbk2_on
25.00Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
25.00Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
25.00Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
25.00Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
25.00Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
25.00Consensusendothelin_onOrthosteric Ligandetb_on eta_on
25.00Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
25.00Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
25.00Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
25.00Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
25.00Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
25.00Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
25.00Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
25.00Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
25.00Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
25.00Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
24.32Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
24.24Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
24.24Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
24.24Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
24.24Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
24.24Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
24.24Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
24.24Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
24.24Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ22
24.24Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
24.24Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
24.24Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
24.24Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
24.24Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
24.14Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
24.14Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
24.14Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
24.14Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
24.14Single6H7LDobutamine6H7L-β1-Dobutamine
24.14Single6K1QIRL25006K1Q-ETB-IRL2500
24.14Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
24.14Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
24.14Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
24.14Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
24.14Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
24.14Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
24.14Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
24.14Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
24.14Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
24.14Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
24.14Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/β1/γ2
24.14Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
24.14Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
24.14Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
24.14Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
24.14Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
24.00Single2YDOAdenosine2YDO-A2A-Adenosine
24.00Single3REYXAC3REY-A2A-XAC
24.00Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
24.00Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
24.00Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
24.00Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
24.00Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
24.00Single5UVIZM-2413855UVI-A2A-ZM-241385
24.00Single6AQFZM-2413856AQF-A2A-ZM-241385
24.00Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
24.00Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
24.00Single6MH8ZM-2413856MH8-A2A-ZM-241385
24.00Single6PS0S-Carazolol6PS0-β2-S-Carazolol
24.00Single6PS4ICI118-5516PS4-β2-ICI118-551
24.00Single6PS5S-Propranolol6PS5-β2-S-Propranolol
24.00Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
24.00Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
24.00Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
24.00Single6ZG9GSK10347026ZG9-M1-GSK1034702
24.00Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
24.00Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
24.00Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
24.00Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
24.00Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
24.00Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
24.00Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
24.00Single7T32ZM-2413857T32-A2A-ZM-241385
24.00Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
24.00Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
24.00Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
24.00Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
24.00Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
24.00Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
24.00Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
24.00Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
24.00Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
24.00Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
24.00Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
24.00Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
24.00Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
24.00Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
24.00Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
24.00Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
24.00Single8K9LDamgo8K9L-μ-Damgo-VV9-Gi3/β1/γ1
24.00Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
24.00Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
24.00Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
24.00Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
24.00Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
24.00Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
24.00Single8ZPMAMD0708ZPM-CXCR4-AMD070-Cholesterol
24.00Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
24.00Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
24.00Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
24.00Consensusalpha1_onOrthosteric Ligandalpha1a_on
24.00Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
24.00Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
24.00Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
24.00Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
24.00Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
24.00Consensusgrh_offOrthosteric Ligandgnrh1_off
23.68Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
23.68Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
23.68Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
23.53Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
23.53Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
23.53Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
23.53Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
23.53Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
23.53Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
23.53Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
23.53Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.53Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
23.53Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
23.53Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
23.53Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
23.53Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
23.53Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
23.53Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
23.53Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
23.33Single5EE7MK08935EE7-Glucagon-MK0893
23.33Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
23.33Single5WF6UK-4320975WF6-A2A-UK-432097
23.33Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
23.33Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
23.33Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
23.33Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
23.33Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
23.33Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
23.33Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
23.33Consensuskisspeptin_onOrthosteric Ligandkiss1_on
23.08Single2Y04Salbutamol2Y04-β1-Salbutamol
23.08Single3NY8ICI118-5513NY8-β2-ICI118-551
23.08Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
23.08Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
23.08Single4GBRS-Carazolol4GBR-β2-S-Carazolol
23.08Single4QKX35V4QKX-β2-35V
23.08Single6DRXLisuride6DRX-5-HT2B-Lisuride
23.08Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
23.08Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/β1/γ2
23.08Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
23.08Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
23.08Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
23.08Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
23.08Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
23.08Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
23.08Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
23.08Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
23.08Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
23.08Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
23.08Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
23.08Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
23.08Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
23.08Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
23.08Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
23.08Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
23.08Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
23.08Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
23.08Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
23.08Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
23.08Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
23.08Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.08Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.08Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.08Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.08Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.08Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.08Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.08Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.08Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.08Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.08Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
23.08Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
23.08Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
23.08Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
23.08Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
23.08Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
23.08Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
23.08Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
23.08Single8JJOAlprenolol8JJO-β2-Alprenolol
23.08Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
23.08Single8JXRLSD8JXR-D1-LSD
23.08Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
23.08Single8T1WCVN4248T1W-GPR6-CVN424
23.08Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
23.08Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.08Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.08Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.08Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.08Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
23.08Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
23.08Single8X63Mepyramine8X63-H1-Mepyramine
23.08Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
23.08Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
23.08Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
23.08Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
23.08Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
23.08Consensus5ht5_onOrthosteric Ligand5ht5a_on
23.08Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
23.08Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
23.08Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
23.08Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
23.08Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
23.08Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
23.08Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
23.08Consensusalpha2_onOrthosteric Ligandalpha2b_on
23.08Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
23.08Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
23.08Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
23.08Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
23.08Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
23.08Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
23.08Consensusblt_onOrthosteric Ligandblt1_on
23.08Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
23.08Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
23.08Consensusdopamine_offOrthosteric Ligandd2_off d3_off
23.08Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
23.08Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
23.08Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
23.08Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
23.08Consensushistamine_offOrthosteric Ligandh1_off
23.08Consensusleukotriene_onOrthosteric Ligandblt_on
23.08Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
23.08Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
23.08Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
23.08Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
22.86Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
22.86Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
22.86Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
22.86Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
22.86Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
22.86Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
22.86Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
22.73Single3OE8IT1t3OE8-CXCR4-IT1t
22.73Single3RFMCaffeine3RFM-A2A-Caffeine
22.73Single6TQ9SB-4081246TQ9-OX1-SB-408124
22.73Single8A2OTheophylline8A2O-A2A-Theophylline-Na
22.73Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.73Single9CHUNoradrenaline9CHU-β2-Noradrenaline
22.58Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
22.58Single4IARErgotamine4IAR-5-HT1B-Ergotamine
22.58Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
22.58Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
22.58Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
22.58Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
22.58Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.58Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
22.58Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
22.58Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
22.58Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
22.50Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
22.50Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
22.22Single2RH1S-Carazolol2RH1-β2-S-Carazolol
22.22Single2Y03Isoprenaline2Y03-β1-Isoprenaline
22.22Single2YCWS-Carazolol2YCW-β1-S-Carazolol
22.22Single5D6LS-Carazolol5D6L-β2-S-Carazolol
22.22Single5JQHS-Carazolol5JQH-β2-S-Carazolol
22.22Single5TVNLSD5TVN-5-HT2B-LSD
22.22Single5WIUNemonapride5WIU-D4-Nemonapride
22.22Single5WIVNemonapride5WIV-D4-Nemonapride-Na
22.22Single5XPRBosentan5XPR-ETB-Bosentan
22.22Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
22.22Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
22.22Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
22.22Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
22.22Single6E67BI1671076E67-β2-BI167107-Gs (fused)
22.22Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
22.22Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
22.22Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
22.22Single6PS6Timolol6PS6-β2-Timolol
22.22Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
22.22Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
22.22Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
22.22Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
22.22Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
22.22Single7SINNPS-21437SIN-CaS-NPS-2143
22.22Single7SINNPS-21437SIN-CaS-NPS-2143
22.22Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
22.22Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
22.22Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
22.22Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.22Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
22.22Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
22.22Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
22.22Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
22.22Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
22.22Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
22.22Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
22.22Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
22.22Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
22.22Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
22.22Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
22.22Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
22.22Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
22.22Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
22.22Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
22.22Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
22.22Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
22.22Consensusamine_offonOrthosteric Ligandamine_off amine_on
22.22Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
22.22Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
22.22Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
22.22Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
22.22Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
22.22Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
22.22Consensusep_offOrthosteric Ligandep4_off
22.22Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
22.22Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
22.22Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
22.22Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
22.22Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
22.22Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
22.22Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
22.22Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
22.22Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
22.22Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
22.22Consensustrace-amine_onOrthosteric Ligandta1_on
21.95Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
21.88Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
21.88Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
21.88Single7XNACYN1548067XNA-SST2-CYN154806
21.88Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
21.88Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
21.74Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
21.74Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
21.74Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
21.74Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
21.74Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
21.74Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.74Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
21.74Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
21.74Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
21.74Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
21.74Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
21.74Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
21.74Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
21.74Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
21.74Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
21.74Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
21.74Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
21.74Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
21.62Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
21.62Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
21.62Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
21.62Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
21.62Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
21.62Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
21.43Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
21.43Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
21.43Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
21.43Single4BV0Neurotensin4BV0-NTS1-Neurotensin
21.43Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
21.43Single5D5AS-Carazolol5D5A-β2-S-Carazolol
21.43Single5D5BS-Carazolol5D5B-β2-S-Carazolol
21.43Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
21.43Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
21.43Single6WGTLSD6WGT-5-HT2A-LSD
21.43Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
21.43Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
21.43Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
21.43Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
21.43Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
21.43Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
21.43Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.43Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
21.43Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
21.43Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
21.43Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
21.43Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
21.43Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
21.43Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
21.43Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
21.43Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
21.43Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
21.43Single9BJKNAM9BJK-μ-Naloxone-NAM
21.43Single9F33FOB02-04A9F33-D3-FOB02-04A-Go1/β1/γ2
21.43Single9GE2ML1849GE2-GPR55-ML184-Cholesterol-chim(CtGi1-G13)/β1/γ2
21.43Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
21.43Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
21.43Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
21.43Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
21.43Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
21.43Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
21.43Consensusneurotensin_onOrthosteric Ligandnts1_on
21.43Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
21.43Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
21.43Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
21.43Consensustachykinin_offOrthosteric Ligandnk1_off
21.43Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
21.21Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
21.21Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
21.21Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
21.21Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
21.21Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
21.21Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
21.21Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
21.05Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
21.05Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/β1/γ2
20.93Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
20.83Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
20.83Single6TP4ACT-4622066TP4-OX1-ACT-462206
20.83Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
20.83Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
20.83Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
20.83Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
20.83Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
20.83Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
20.83Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
20.83Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
20.83Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
20.83Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.83Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
20.83Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
20.83Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
20.83Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
20.83Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go1/β1/γ2
20.83Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
20.83Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
20.83Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
20.83Single8YN7Immethridine8YN7-H3-Immethridine-Go1/β1/γ2
20.83Single8YRGFospropofol8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
20.83Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
20.83Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
20.83Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
20.69Single3D4STimolol3D4S-β2-Timolol
20.69Single4AMIBucindolol4AMI-β1-Bucindolol
20.69Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
20.69Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
20.69Single4PY02MeSATP4PY0-P2Y12-2MeSATP
20.69Single4XEENeurotensin4XEE-NTS1-Neurotensin
20.69Single4XESNeurotensin4XES-NTS1-Neurotensin
20.69Single6CM4Risperidone6CM4-D2-Risperidone
20.69Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
20.69Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
20.69Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
20.69Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
20.69Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
20.69Single7K15MKD0467K15-BLT1-MKD046-Na
20.69Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
20.69Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
20.69Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
20.69Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.69Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.69Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
20.69Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
20.69Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
20.69Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
20.69Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
20.69Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
20.69Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
20.69Single8XJNCloprosetnol8XJN-TP-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
20.69Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
20.69Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
20.69Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
20.69Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
20.69Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
20.69Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
20.69Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
20.69Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
20.69Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
20.69Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
20.69Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
20.69Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
20.69Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
20.69Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
20.69Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
20.59Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
20.59Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
20.59Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
20.59Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
20.59Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
20.51Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
20.00Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
20.00Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
20.00Single4BUONeurotensin4BUO-NTS1-Neurotensin
20.00Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
20.00Single6DS0Ly2660976DS0-5-HT2B-Ly266097
20.00Single6IBLArformoterol6IBL-β1-Arformoterol
20.00Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
20.00Single6ME2Ramelteon6ME2-MT1-Ramelteon
20.00Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
20.00Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
20.00Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
20.00Single7BR3Elagolix7BR3-GnRH1-Elagolix
20.00Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
20.00Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
20.00Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
20.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
20.00Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
20.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
20.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
20.00Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
20.00Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
20.00Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
20.00Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
20.00Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
20.00Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
20.00Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
20.00Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
20.00Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
20.00Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
20.00Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
20.00Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
20.00Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
20.00Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
20.00Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
20.00Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
20.00Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
20.00Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
20.00Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
20.00Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
20.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
20.00Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
20.00Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/β1/γ2
20.00Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
20.00Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
20.00Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ
20.00Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
20.00Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
20.00Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(CtGi1-G13)/β1/γ2
20.00Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
20.00Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
20.00Consensuschemerin_onOrthosteric Ligandcml1_on
20.00Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
20.00Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
20.00Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
20.00Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
20.00Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
20.00Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
20.00Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
20.00Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
20.00Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
20.00Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
20.00Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
20.00Consensustp_onOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Consensustp_on_gpOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
19.44Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
19.44Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
19.35Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
19.35Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
19.35Single8IEIA1LYA8IEI-GPR156-A1LYA
19.35Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
19.35Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
19.35Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
19.35Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
19.35Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
19.35Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
19.35Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
19.35Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
19.23Single3RZECidoxepin3RZE-H1-Cidoxepin
19.23Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
19.23Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
19.23Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
19.23Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
19.23Single6VI4JDTic6VI4-κ-JDTic
19.23Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
19.23Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
19.23Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
19.23Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
19.23Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
19.23Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
19.23Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
19.23Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
19.23Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
19.23Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
19.23Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
19.23Single7UL3Famotidine7UL3-H2-Famotidine
19.23Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
19.23Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
19.23Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
19.23Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
19.23Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
19.23Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
19.23Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
19.23Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
19.23Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
19.23Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
19.23Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
19.23Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.23Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.23Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
19.23Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
19.23Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
19.23Single8K2WAMG4878K2W-CXCR3-AMG487
19.23Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
19.23Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
19.23Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
19.23Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
19.23Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.23Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.23Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
19.23Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
19.23Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
19.23Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
19.23Single8YN8Proxyfan8YN8-H3-Proxyfan-Go1/β1/γ2
19.23Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
19.23Single8ZPNAMD31008ZPN-CXCR4-AMD3100-Cholesterol
19.23Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
19.23Single9BJKNaloxone9BJK-μ-Naloxone-NAM
19.23Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
19.23Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Cholesterol-Gi1/β1/γ2
19.23Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
19.23Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
19.23Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
19.23Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
19.23Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
19.05Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
18.92Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
18.92Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
18.92Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
18.92Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
18.92Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
18.92Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
18.75Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
18.75Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
18.75Single8IEPA1LYA8IEP-GPR156-A1LYA
18.75Single8IEPA1LYA8IEP-GPR156-A1LYA
18.75Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
18.75Single8XWNCXCL88XWN-CXCR2-CXCL8
18.75Consensussomatostatin_offOrthosteric Ligandsst2_off
18.52Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
18.52Single2Y02Carmoterol2Y02-β1-Carmoterol
18.52Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
18.52Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
18.52Single4DAJTiotropium4DAJ-M3-Tiotropium
18.52Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
18.52Single4MQSIperoxo4MQS-M2-Iperoxo
18.52Single4U14Tiotropium4U14-M3-Tiotropium
18.52Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
18.52Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
18.52Single5TGZAM65385TGZ-CB1-AM6538
18.52Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
18.52Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
18.52Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
18.52Single6D27CAY104716D27-DP2-CAY10471
18.52Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
18.52Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
18.52Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
18.52Single6GPSMK08126GPS-CCR2-MK0812
18.52Single6H7MSalbutamol6H7M-β1-Salbutamol
18.52Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
18.52Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.52Single7BU7BI1671077BU7-β1-BI167107
18.52Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
18.52Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
18.52Single7F83PF-051904577F83-Ghrelin-PF-05190457
18.52Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
18.52Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
18.52Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
18.52Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
18.52Single7WC7Lisuride7WC7-5-HT2A-Lisuride
18.52Single7YXAONO-54306087YXA-S1P5-ONO-5430608
18.52Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
18.52Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
18.52Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
18.52Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
18.52Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
18.52Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
18.52Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
18.52Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
18.52Single8X64Desloratadine8X64-H1-Desloratadine
18.52Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
18.52Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
18.52Single9IYAONO-97105319IYA-GPR55-ONO-9710531
18.52Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
18.52Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
18.52Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
18.52Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
18.52Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
18.52Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
18.52Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
18.42Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
18.42Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
18.42Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
18.42Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
18.18Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
18.18Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
18.18Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
18.18Single8IEBA1LYA8IEB-GPR156-A1LYA
18.18Single8PWNTheophylline8PWN-A2A-Theophylline
18.18Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
18.18Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
17.95Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
17.86Single2Y00Dobutamine2Y00-β1-Dobutamine
17.86Single4NTJAZD12834NTJ-P2Y12-AZD1283
17.86Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
17.86Single6GPXMK08126GPX-CCR2-MK0812
17.86Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
17.86Single6LUQHaloperidol6LUQ-D2-Haloperidol
17.86Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
17.86Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
17.86Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
17.86Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
17.86Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
17.86Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
17.86Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
17.86Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
17.86Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
17.86Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
17.86Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.86Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
17.86Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
17.86Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
17.86Single8ZMFA1L108ZMF-5-HT2C-A1L10
17.86Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
17.86Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
17.86Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
17.86Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
17.86Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
17.86Consensusblt_offOrthosteric Ligandblt1_off
17.86Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
17.86Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
17.86Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
17.86Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
17.86Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
17.86Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
17.86Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
17.86Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.86Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.65Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.50Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
17.50Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
17.39Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
17.39Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
17.39Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
17.39Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
17.39Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
17.39Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
17.39Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
17.39Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
17.24Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
17.24Single4U15Tiotropium4U15-M3-Tiotropium
17.24Single5V54Methiothepin5V54-5-HT1B-Methiothepin
17.24Single5V56TC1145V56-SMO-TC114
17.24Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
17.24Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
17.24Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
17.24Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
17.24Single6OL9Tiotropium6OL9-M5-Tiotropium
17.24Single6OS1TRV0266OS1-AT1-TRV026
17.24Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
17.24Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
17.24Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
17.24Single8EA0Iperoxo8EA0-M3-Iperoxo
17.24Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
17.24Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
17.24Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
17.24Consensus5ht1_offOrthosteric Ligand5ht1b_off
17.24Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
17.24Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
17.24Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
17.24Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
17.24Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
17.24Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
17.24Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
17.24Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
17.24Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
17.14Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
17.14Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
17.14Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
17.14Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
17.14Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
16.67Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
16.67Single3UZAGTPL92363UZA-A2A-GTPL9236
16.67Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
16.67Single4N4WSANT-14N4W-SMO-SANT-1
16.67Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
16.67Single5CXVTiotropium5CXV-M1-Tiotropium
16.67Single5X33BIIL2605X33-BLT1-BIIL260
16.67Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
16.67Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
16.67Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
16.67Single6IIURamatroban6IIU-TP-Ramatroban
16.67Single6ME5Agomelatine6ME5-MT1-Agomelatine
16.67Single6OS2TRV0266OS2-AT1-TRV026
16.67Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
16.67Single6YVRNTS8-136YVR-NTS1-NTS8-13
16.67Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
16.67Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
16.67Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
16.67Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/β1/γ2
16.67Single7WC5Psilocin7WC5-5-HT2A-Psilocin
16.67Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
16.67Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
16.67Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
16.67Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
16.67Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
16.67Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
16.67Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
16.67Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
16.67Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
16.67Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
16.67Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
16.67Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
16.67Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
16.67Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
16.67Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
16.67Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
16.13Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
16.13Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
16.13Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
16.13Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
16.13Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-PubChem 118610427-chim(NtGi1-Go)/β1/γ2
16.13Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
16.13Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
16.13Single8XVJMacitentan8XVJ-ETA-Macitentan
16.13Single8XVUCXCL28XVU-CXCR2-CXCL2
16.13Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
16.13Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
16.00Single3PBLEticlopride3PBL-D3-Eticlopride
16.00Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
16.00Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
16.00Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
16.00Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
16.00Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
16.00Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
16.00Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
16.00Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
16.00Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
16.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
16.00Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
16.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.00Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
16.00Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
16.00Single9B9Y7DY9B9Y-CB1-7DY
16.00Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
16.00Consensusgq_nucleotideOrthosteric Ligandgq_p2y
16.00Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
16.00Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
16.00Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
15.79Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
15.62Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
15.62Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
15.62Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
15.62Single8XQJJN2418XQJ-Apelin-JN241
15.62Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
15.62Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
15.38Single4BWBNeurotensin4BWB-NTS1-Neurotensin
15.38Single5U09Taranabant5U09-CB1-Taranabant
15.38Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
15.38Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
15.38Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
15.38Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
15.38Single6ME9Ramelteon6ME9-MT2-Ramelteon
15.38Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
15.38Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
15.38Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
15.38Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
15.38Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
15.38Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
15.38Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
15.38Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
15.38Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
15.38Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
15.38Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.38Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
15.38Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
15.38Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
15.38Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
15.38Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
15.22Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
15.15Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
15.15Single8IEIA1LYA8IEI-GPR156-A1LYA
15.15Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
14.89Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
14.81Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
14.81Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
14.81Single6A94Zotepine6A94-5-HT2A-Zotepine
14.81Single6KUXRS-799486KUX-α2a-RS-79948
14.81Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
14.81Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
14.81Single7VV6C48/807VV6-MRGPRX2-C48/80
14.81Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.81Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
14.81Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
14.81Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
14.81Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
14.81Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
14.81Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.81Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
14.81Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
14.81Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
14.81Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
14.81Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
14.81Consensusopsins_offOrthosteric Ligandrhodopsin_off
14.81Consensussensory_offOrthosteric Ligandopsins_off
14.71Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
14.71Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
14.63Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
14.29Single2Y01Dobutamine2Y01-β1-Dobutamine
14.29Single4QIMANTA XV4QIM-SMO-ANTA XV
14.29Single5DSGTiotropium5DSG-M4-Tiotropium
14.29Single5T04Neurotensin5T04-NTS1-Neurotensin
14.29Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
14.29Single6IIVDaltroban6IIV-TP-Daltroban
14.29Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
14.29Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
14.29Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
14.29Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
14.29Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
14.29Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
14.29Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
14.29Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
14.29Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
14.29Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
14.29Single9B9ZA1AKO9B9Z-CB1-A1AKO
14.29Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
14.29Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
14.29Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
13.95Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
13.95Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
13.89Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
13.79Single4JKVTaladegib4JKV-SMO-Taladegib
13.79Single5CGCHTL142425CGC-mGlu5-HTL14242
13.79Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
13.79Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
13.79Single6Z4SSR486926Z4S-NTS1-SR48692
13.79Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
13.79Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
13.79Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
13.79Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
13.79Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
13.79Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
13.64Single5MZPCaffeine5MZP-A2A-Caffeine-Na
13.64Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
13.64Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
13.51Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
13.33Single5V57TC1145V57-SMO-TC114
13.33Single7R0CAVP7R0C-V2-AVP-Arrestin2
13.33Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
13.33Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
13.33Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
13.33Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
13.33Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
13.33Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
13.33Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
13.16Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
13.04Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
13.04Single7WC4Serotonin7WC4-5-HT2A-Serotonin
13.04Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
13.04Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
12.90Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
12.90Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
12.90Single8XWACXCL18XWA-CXCR2-CXCL1
12.90Single8XWMCXCL68XWM-CXCR2-CXCL6
12.90Single8XWSCXCL58XWS-CXCR2-CXCL5
12.50Single5CGDHTL142425CGD-mGlu5-HTL14242
12.50Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
12.50Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
12.50Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
12.50Single8XWFCXCL38XWF-CXCR2-CXCL3
12.50Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
12.50Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
12.50Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
12.12Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
12.12Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
12.00Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
12.00Single4XNWMRS25004XNW-P2Y1-MRS2500
12.00Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
12.00Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
12.00Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
12.00Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
12.00Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
12.00Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
12.00Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
12.00Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
12.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
12.00Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
12.00Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
12.00Consensusgi_sensoryOrthosteric Ligandgi_opsins
12.00Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
12.00Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
12.00Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
11.76Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
11.76Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
11.76Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
11.76Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
11.54Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
11.54Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
11.54Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
11.54Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
11.54Single5L7IVismodegib5L7I-SMO-Vismodegib
11.54Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
11.54Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
11.54Single6LI0C176LI0-GPR52-C17
11.54Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
11.54Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
11.54Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.54Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
11.54Single7UL2SR486927UL2-NTS1-SR48692-Na
11.54Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
11.54Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
11.54Consensusneurotensin_offOrthosteric Ligandnts1_off
11.54Consensusnts1_offOrthosteric Ligand7UL2-NTS1-SR48692-Na
11.11Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
11.11Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
11.11Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
11.11Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
11.11Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
11.11Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
11.11Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
11.11Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
11.11Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
11.11Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
11.11Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
11.11Single9BA0A1AKN9BA0-CB1-A1AKN
11.11Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
11.11Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
11.11Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
11.11Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
11.11Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
11.11Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
11.11Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
10.81Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
10.71Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
10.71Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
10.71Single6ZINSR486926ZIN-NTS1-SR48692
10.71Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
10.71Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
10.71Single7VODCariprazine7VOD-5-HT2A-Cariprazine
10.71Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
10.71Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
10.71Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
10.71Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
10.71Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
10.53Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
10.53Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
10.34Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
10.34Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
10.34Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
10.34Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
10.34Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
10.00Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
10.00Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
10.00Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
10.00Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
10.00Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
10.00Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
10.00Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
10.00Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
9.68Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
9.68Single7F1TMIP-1a7F1T-CCR5-MIP-1a
9.68Single7P2L4YI7P2L-mGlu5-4YI
9.68Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
9.68Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
9.68Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Cholesterol-Gi1/β1/γ1
9.38Single8XQJJN2418XQJ-Apelin-JN241
9.38Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
8.82Single6KNMJN241-96KNM-Apelin-JN241-9
8.70Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single3PXOAll-trans-Retinal3PXO-Rhodopsin-All-trans-Retinal
8.33Single5DYSAll-trans-Retinal5DYS-Rhodopsin-All-trans-Retinal
8.33Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
8.33Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
8.00Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
8.00Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
8.00Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
8.00Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
8.00Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
8.00Consensusp2y_offOrthosteric Ligandp2y1_off
8.00Consensussensory_onOrthosteric Ligandopsins_on
7.69Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
7.69Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
7.69Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
7.69Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
7.69Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
7.69Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
7.69Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
7.69Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
7.69Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
7.69Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
7.41Single4O9RCyclopamine4O9R-SMO-Cyclopamine
7.41Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
7.41Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
7.41Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
7.41Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
7.14Single4QINSAG1.54QIN-SMO-SAG1.5
7.14Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
7.14Single7VVOPTH7VVO-PTH1-PTH-Gs/β1/γ2
7.14Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
6.90Single6FFIMMPEP6FFI-mGlu5-MMPEP
6.90Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
6.90Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
6.67Single6FFHFenobam6FFH-mGlu5-Fenobam
6.45Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
6.45Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
6.25Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
5.41Single7SHEPI; PE7SHE-GPR158-PI; PE
4.55Single8W8SAA-148W8S-GPR101-AA-14
4.35Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
4.35Single8W8RAA-148W8R-GPR101-AA-14-chim(NtGi1-Gs)/β1/γ2
4.35Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
4.17Single4A4MAll-trans-Retinal4A4M-Rhodopsin-All-trans-Retinal-Gt(CT)
4.17Single5EN0All-trans-Retinal5EN0-Rhodopsin-All-trans-Retinal-Gt(CT)
4.17Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/β1/γ2
4.17Single9IVMLSN33188399IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
4.00Single6VCBLSN31604406VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
4.00Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
4.00Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
4.00Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
4.00Single9GE2Cholesterol9GE2-GPR55-ML184-Cholesterol-chim(CtGi1-G13)/β1/γ2
3.85Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
3.85Single7Y14Beta-Alanine7Y14-MRGPRD-β-Alanine
3.85Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/β1/γ2
3.70Single7Y12Beta-Alanine7Y12-MRGPRD-β-Alanine-Gi1/β1/γ2
3.70Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
3.70Single8JPSCCL78JPS-ACKR1-CCL7
3.57Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
3.57Single8HSCFab0468HSC-GPR20-Fab046-Gi1/β1/γ2
3.57Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
3.57Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
3.57Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
3.45Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
3.45Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
3.45Single8G94CD698G94-S1P1-CD69-Gi1/β1/γ2
3.45Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
3.45Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
3.33Single8IYXYL-3658IYX-GPR34-YL-365
3.23Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
3.12Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
3.12Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
3.03Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
2.94Single7SHEPI; PE7SHE-GPR158-PI; PE
2.86Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
2.63Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7

Consensus Members
Id Members
7F4H 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
7F4D 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
7F4I 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
Net Summary
Imin 3.74667
Number of Linked Nodes 878
Number of Links 1024
Number of Hubs 154
Number of Links mediated by Hubs 590
Number of Communities 27
Number of Nodes involved in Communities 199
Number of Links involved in Communities 275
Path Summary
Number Of Nodes in MetaPath 113
Number Of Links MetaPath 112
Number of Shortest Paths 1775060
Length Of Smallest Path 3
Average Path Length 33.8413
Length of Longest Path 65
Minimum Path Strength 0.405
Average Path Strength 7.78457
Maximum Path Strength 23.4817
Minimum Path Correlation 0.7
Average Path Correlation 0.982562
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.08333
Average % Of Corr. Nodes 41.2604
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 47.5829
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following consensuses:
IdComponents
melanocortin_on_gpmc1_on_gp
mc4_on_gp
mc2_on_gp
mc3_on_gp
mc5_on_gp



You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download mc1_on_gp.zip



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