psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I32	R:R:L28	2.85	No	No	0	5	4
2	R:R:G31	R:R:H30	1.59	No	No	0	5	5
3	R:R:H30	R:R:T437	4.11	No	No	0	5	6
4	R:R:G31	R:R:S92	1.86	No	No	0	5	7
5	R:R:I32	R:R:S35	3.1	No	Yes	0	5	6
6	R:R:R34	R:R:T437	2.59	No	No	5	6	6
7	R:R:R34	R:R:W441	3	No	Yes	5	6	8
8	R:R:S35	R:R:T36	1.6	Yes	No	0	6	4
9	R:R:S35	R:R:V89	1.62	Yes	No	0	6	8
10	R:R:S35	R:R:S92	3.26	Yes	No	0	6	7
11	R:R:V37	R:R:W441	8.58	No	Yes	0	5	8
12	R:R:L38	R:R:L42	2.77	No	No	0	7	8
13	R:R:I40	R:R:V39	3.07	No	No	0	5	5
14	R:R:V39	R:R:V89	1.6	No	No	0	5	8
15	R:R:F41	R:R:L445	2.44	No	No	0	7	6
16	R:R:I81	R:R:L42	5.71	No	No	0	8	8
17	R:R:N49	R:R:S45	2.98	Yes	Yes	1	9	8
18	R:R:I81	R:R:S45	3.1	No	Yes	1	8	8
19	R:R:C447	R:R:S45	3.44	No	Yes	1	9	8
20	R:R:C448	R:R:S45	1.72	No	Yes	0	7	8
21	R:R:F46	R:R:I50	3.77	No	No	0	6	6
22	R:R:F46	R:R:L78	3.65	No	No	0	6	8
23	R:R:G48	R:R:V47	1.84	No	No	0	9	5
24	R:R:L74	R:R:N49	4.12	Yes	Yes	1	9	9
25	R:R:D77	R:R:N49	9.42	No	Yes	1	9	9
26	R:R:L78	R:R:N49	5.49	No	Yes	1	8	9
27	R:R:N49	R:R:P451	6.52	Yes	Yes	1	9	9
28	R:R:L52	R:R:P451	1.64	No	Yes	0	9	9
29	R:R:G455	R:R:L52	1.71	No	No	0	8	9
30	R:R:A53	R:R:L74	3.15	No	Yes	0	7	9
31	R:R:E464	R:R:V55	2.85	No	No	0	8	9
32	R:R:I465	R:R:V55	6.14	No	No	0	8	9
33	R:R:M468	R:R:V55	3.04	No	No	0	7	9
34	R:R:L56	R:R:N67	5.49	No	Yes	0	8	9
35	R:R:I70	R:R:L56	2.85	No	No	0	8	8
36	R:R:F71	R:R:Q57	3.51	No	No	0	8	5
37	R:R:K59	R:R:R58	3.71	No	No	0	7	7
38	R:R:K59	R:R:P60	1.67	No	No	0	7	7
39	R:R:E464	R:R:K59	9.45	No	No	0	8	7
40	R:R:P60	R:R:Q61	7.9	No	No	0	7	6
41	R:R:L62	R:R:L63	5.54	No	Yes	6	9	8
42	R:R:L62	R:R:N67	6.87	No	Yes	6	9	9
43	R:R:L63	R:R:T66	5.9	Yes	No	0	8	8
44	R:R:L63	R:R:N67	2.75	Yes	Yes	6	8	9
45	R:R:H458	R:R:L63	2.57	Yes	Yes	0	9	8
46	R:R:M143	R:R:V65	3.04	Yes	No	0	8	7
47	R:R:Q145	R:R:V65	4.3	No	No	0	5	7
48	R:R:I70	R:R:T66	3.04	No	No	0	8	8
49	R:R:N67	R:R:R68	2.41	Yes	No	0	9	8
50	R:R:R68	R:R:Y149	3.09	No	No	0	8	5
51	R:R:F69	R:R:V124	6.55	Yes	No	0	8	8
52	R:R:F69	R:R:V125	2.62	Yes	No	0	8	9
53	R:R:F69	R:R:L151	2.44	Yes	No	0	8	8
54	R:R:F69	R:R:L152	2.44	Yes	No	0	8	9
55	R:R:F71	R:R:L74	2.44	No	Yes	0	8	9
56	R:R:F71	R:R:V75	5.24	No	No	0	8	7
57	R:R:N72	R:R:T121	8.77	No	No	0	9	8
58	R:R:L152	R:R:N72	12.36	No	No	0	9	9
59	R:R:N72	R:R:W156	5.65	No	No	0	9	9
60	R:R:L73	R:R:S118	3	No	Yes	1	9	9
61	R:R:H450	R:R:L73	7.71	Yes	No	1	9	9
62	R:R:L74	R:R:L78	4.15	Yes	No	1	9	8
63	R:R:F114	R:R:T76	2.59	Yes	Yes	0	7	9
64	R:R:A117	R:R:T76	1.68	No	Yes	1	8	9
65	R:R:S118	R:R:T76	1.6	Yes	Yes	1	9	9
66	R:R:T76	R:R:W156	3.64	Yes	No	1	9	9
67	R:R:C447	R:R:D77	7.78	No	No	1	9	9
68	R:R:D77	R:R:P451	1.61	No	Yes	1	9	9
69	R:R:F114	R:R:L79	4.87	Yes	No	0	7	7
70	R:R:Q80	R:R:V84	2.87	No	Yes	0	8	9
71	R:R:F114	R:R:Q80	9.37	Yes	No	0	7	8
72	R:R:C447	R:R:I81	6.55	No	No	1	9	8
73	R:R:L83	R:R:S82	6.01	No	No	0	6	4
74	R:R:L110	R:R:L83	2.77	No	No	0	6	6
75	R:R:V84	R:R:V88	1.6	Yes	No	8	9	8
76	R:R:T111	R:R:V84	3.17	No	Yes	0	9	9
77	R:R:F444	R:R:V84	2.62	Yes	Yes	8	8	9
78	R:R:A85	R:R:P86	1.87	No	No	0	8	9
79	R:R:F103	R:R:W87	10.02	No	No	0	5	6
80	R:R:L107	R:R:W87	3.42	No	No	0	7	6
81	R:R:F444	R:R:V88	2.62	Yes	No	8	8	8
82	R:R:P94	R:R:V93	5.3	No	No	0	5	6
83	R:R:L95	R:R:V93	4.47	No	No	0	5	6
84	R:R:F96	R:R:L99	4.87	No	No	0	4	7
85	R:R:F96	W:W:?2	9.36	No	No	0	4	0
86	R:R:F175	R:R:W97	5.01	Yes	Yes	3	5	9
87	R:R:E177	R:R:W97	10.9	No	Yes	3	4	9
88	R:R:A180	R:R:W97	2.59	No	Yes	3	3	9
89	R:R:F103	R:R:L99	8.53	No	No	0	5	7
90	R:R:N100	W:W:?2	14.08	No	No	0	8	0
91	R:R:S101	R:R:T105	1.6	No	No	0	4	7
92	R:R:C104	R:R:C182	7.28	No	No	0	9	9
93	R:R:A173	R:R:T105	1.68	No	No	0	5	7
94	R:R:H112	R:R:V108	6.92	No	No	0	8	7
95	R:R:S109	R:R:T164	3.2	No	No	0	8	7
96	R:R:L167	R:R:S109	7.51	No	No	0	8	8
97	R:R:F114	R:R:L110	8.53	Yes	No	0	7	6
98	R:R:H112	R:R:M184	2.63	No	Yes	0	8	7
99	R:R:H112	R:R:Y415	4.36	No	No	0	8	9
100	R:R:F114	R:R:L113	2.44	Yes	No	0	7	8
101	R:R:F116	R:R:Q162	9.37	Yes	No	0	9	8
102	R:R:F116	R:R:S163	6.61	Yes	No	0	9	8
103	R:R:F116	R:R:F200	11.79	Yes	Yes	0	9	8
104	R:R:A117	R:R:W156	3.89	No	No	1	8	9
105	R:R:A117	R:R:A159	1.79	No	No	0	8	9
106	R:R:Q446	R:R:S118	2.89	Yes	Yes	1	9	9
107	R:R:H450	R:R:S118	5.58	Yes	Yes	1	9	9
108	R:R:N120	R:R:V119	2.96	No	No	0	8	9
109	R:R:P204	R:R:V119	3.53	Yes	No	9	9	9
110	R:R:V119	R:R:Y408	2.52	No	Yes	9	9	9
111	R:R:N120	R:R:T155	5.85	No	No	0	8	8
112	R:R:N120	R:R:V158	2.96	No	No	0	8	5
113	R:R:T121	R:R:V125	1.59	No	No	0	8	9
114	R:R:H450	R:R:I122	5.3	Yes	No	0	9	9
115	R:R:I122	R:R:Y454	7.25	No	No	0	9	9
116	R:R:P204	R:R:V123	3.53	Yes	No	0	9	7
117	R:R:V123	R:R:V207	1.6	No	Yes	0	7	7
118	R:R:S126	R:R:V127	1.62	No	No	4	9	7
119	R:R:S126	R:R:V207	1.62	No	Yes	4	9	7
120	R:R:M208	R:R:S126	3.07	Yes	No	0	9	9
121	R:R:V127	R:R:V207	1.6	No	Yes	4	7	7
122	R:R:C211	R:R:V127	1.71	No	No	4	8	7
123	R:R:D128	R:R:Y139	5.75	No	Yes	7	9	9
124	R:R:D128	R:R:M143	5.54	No	Yes	7	9	8
125	R:R:H458	R:R:R129	2.26	Yes	No	0	9	9
126	R:R:I134	R:R:Y130	3.63	Yes	No	0	8	9
127	R:R:C211	R:R:Y130	6.72	No	No	0	8	9
128	R:R:S132	R:R:Y139	2.54	No	Yes	0	8	9
129	R:R:I133	R:R:V215	9.22	No	No	0	8	9
130	R:R:H135	R:R:I134	10.61	No	Yes	0	7	8
131	R:R:I134	R:R:V214	3.07	Yes	No	0	8	6
132	R:R:A218	R:R:I134	1.62	No	Yes	0	7	8
133	R:R:S138	R:R:S141	3.26	No	No	0	6	5
134	R:R:K142	R:R:S138	4.59	No	No	0	7	6
135	R:R:P140	R:R:Y139	4.17	No	Yes	0	7	9
136	R:R:M143	R:R:Y139	4.79	Yes	Yes	7	8	9
137	R:R:L151	R:R:M143	2.83	No	Yes	0	8	8
138	R:R:R147	R:R:T144	3.88	No	No	0	8	9
139	R:R:G148	R:R:L151	1.71	No	No	0	8	8
140	R:R:G154	R:R:I157	1.76	No	No	0	4	5
141	R:R:Q162	R:R:V158	2.87	No	No	0	8	5
142	R:R:S163	R:R:T164	4.8	No	No	0	8	7
143	R:R:P165	R:R:P166	7.79	No	Yes	2	8	8
144	R:R:P165	R:R:W170	6.76	No	Yes	2	8	7
145	R:R:P165	R:R:Y192	8.34	No	Yes	2	8	8
146	R:R:G171	R:R:P166	4.06	No	Yes	0	7	8
147	R:R:M184	R:R:P166	1.68	Yes	Yes	2	7	8
148	R:R:P166	R:R:Y192	6.95	Yes	Yes	2	8	8
149	R:R:G169	R:R:Y168	2.9	No	No	0	8	6
150	R:R:S189	R:R:W170	2.47	Yes	Yes	2	7	7
151	R:R:S191	R:R:W170	3.71	No	Yes	0	6	7
152	R:R:W170	R:R:Y192	6.75	Yes	Yes	2	7	8
153	R:R:G171	R:R:S189	3.71	No	Yes	0	7	7
154	R:R:I185	R:R:Q172	2.74	No	No	0	8	6
155	R:R:A188	R:R:Q172	4.55	No	No	0	5	6
156	R:R:A173	R:R:M184	1.61	No	Yes	0	5	7
157	R:R:E177	R:R:F175	2.33	No	Yes	3	4	5
158	R:R:A180	R:R:F175	5.55	No	Yes	3	3	5
159	R:R:C182	R:R:F175	8.38	No	Yes	0	9	5
160	R:R:D176	R:R:N179	4.04	Yes	No	0	4	4
161	R:R:D176	R:R:L181	2.71	Yes	No	0	4	4
162	R:R:N179	R:R:R178	4.82	No	No	0	4	3
163	R:R:Q433	R:R:R178	4.67	No	No	0	3	3
164	R:R:I436	R:R:N179	7.08	No	No	0	6	4
165	R:R:I440	R:R:L181	2.85	No	No	0	7	4
166	R:R:M184	R:R:W186	8.14	Yes	Yes	0	7	7
167	R:R:M184	R:R:Y192	4.79	Yes	Yes	2	7	8
168	R:R:T193	R:R:W186	13.34	No	Yes	0	8	7
169	R:R:S196	R:R:W186	3.71	No	Yes	0	8	7
170	R:R:W186	R:R:Y415	4.82	Yes	No	0	7	9
171	R:R:A419	R:R:W186	11.67	No	Yes	0	8	7
172	R:R:A422	R:R:W186	2.59	No	Yes	0	5	7
173	R:R:P190	R:R:S189	1.78	No	Yes	0	4	7
174	R:R:S189	R:R:Y192	2.54	Yes	Yes	2	7	8
175	R:R:T193	R:R:V197	1.59	No	No	0	8	7
176	R:R:F200	R:R:S196	5.28	Yes	No	0	8	8
177	R:R:V197	R:R:V420	1.6	No	No	0	7	7
178	R:R:V198	R:R:V202	3.21	No	No	0	7	6
179	R:R:F200	R:R:L412	3.65	Yes	Yes	0	8	9
180	R:R:C416	R:R:F200	4.19	No	Yes	0	8	8
181	R:R:C416	R:R:I201	3.27	No	No	0	8	8
182	R:R:I203	R:R:P204	3.39	No	Yes	0	7	9
183	R:R:P204	R:R:Y408	4.17	Yes	Yes	9	9	9
184	R:R:C211	R:R:V207	1.71	No	Yes	4	8	7
185	R:R:M208	R:R:Y212	2.39	Yes	No	0	9	9
186	R:R:I405	R:R:M208	2.92	No	Yes	0	8	9
187	R:R:M208	R:R:Y408	2.39	Yes	Yes	0	9	9
188	R:R:I401	R:R:Y212	3.63	No	No	0	9	9
189	R:R:I404	R:R:Y212	2.42	No	No	0	9	9
190	R:R:S213	R:R:V214	3.23	No	No	0	4	6
191	R:R:F216	R:R:I401	3.77	Yes	No	0	7	9
192	R:R:A219	R:R:A397	1.79	No	No	0	8	8
193	R:R:L225	R:R:R221	4.86	No	No	0	5	7
194	R:R:H223	R:R:Y227	9.8	No	No	0	6	5
195	R:R:F402	R:R:F406	3.22	No	No	0	7	6
196	R:R:I449	R:R:S407	3.1	No	No	0	7	7
197	R:R:S407	R:R:V453	3.23	No	No	0	7	9
198	R:R:L412	R:R:Y408	2.34	Yes	Yes	0	9	9
199	R:R:L410	R:R:L442	5.54	No	No	0	5	9
200	R:R:Q446	R:R:S411	2.89	Yes	No	0	9	8
201	R:R:I449	R:R:S411	4.64	No	No	0	7	8
202	R:R:G413	R:R:L412	1.71	No	Yes	0	7	9
203	R:R:L412	R:R:Q446	2.66	Yes	Yes	0	9	9
204	R:R:G413	R:R:P414	4.06	No	No	0	7	9
205	R:R:I439	R:R:P414	1.69	No	No	0	7	9
206	R:R:L442	R:R:P414	1.64	No	No	0	9	9
207	R:R:F443	R:R:Y415	9.28	No	No	0	8	9
208	R:R:I436	R:R:L418	2.85	No	No	0	6	7
209	R:R:I439	R:R:L418	5.71	No	No	0	7	7
210	R:R:L421	R:R:V425	2.98	No	No	0	6	7
211	R:R:A422	R:R:V427	1.7	No	No	0	5	5
212	R:R:V423	R:R:W424	8.58	No	No	0	7	6
213	R:R:D426	R:R:T429	5.78	No	No	0	4	8
214	R:R:D426	R:R:Q430	11.75	No	No	0	4	3
215	R:R:V427	R:R:V431	4.81	No	No	0	5	6
216	R:R:P432	R:R:V431	3.53	No	No	10	6	6
217	R:R:V431	R:R:V435	3.21	No	No	10	6	5
218	R:R:P432	R:R:W434	8.11	No	No	0	6	4
219	R:R:P432	R:R:V435	5.3	No	No	10	6	5
220	R:R:T437	R:R:W441	7.28	No	Yes	5	6	8
221	R:R:F444	R:R:I440	2.51	Yes	No	0	8	7
222	R:R:W441	W:W:?1	32.11	Yes	No	0	8	0
223	R:R:F443	R:R:F444	2.14	No	Yes	0	8	8
224	R:R:I449	R:R:L445	4.28	No	No	0	7	6
225	R:R:H450	R:R:Q446	4.95	Yes	Yes	1	9	9
226	R:R:Y452	R:R:Y456	6.95	No	No	0	7	8
227	R:R:V453	R:R:Y454	7.57	No	No	0	9	9
228	R:R:G455	R:R:I461	1.76	No	No	0	8	8
229	R:R:K462	R:R:Y456	3.58	No	No	11	8	8
230	R:R:Q466	R:R:Y456	3.38	No	No	11	7	8
231	R:R:H458	R:R:T460	4.11	Yes	No	0	9	8
232	R:R:H458	R:R:I461	6.63	Yes	No	0	9	8
233	R:R:I461	R:R:I465	2.94	No	No	0	8	8
234	R:R:K462	R:R:Q466	2.71	No	No	11	8	7
235	R:R:A85	R:R:L42	1.58	No	No	0	8	8
236	R:R:P140	R:R:Q64	1.58	No	No	0	7	8
237	R:R:I465	R:R:V51	1.54	No	No	0	8	8
238	R:R:A180	R:R:D176	1.54	No	Yes	0	3	4
239	R:R:I203	R:R:V198	1.54	No	No	0	7	7
240	R:R:I206	R:R:V202	1.54	No	No	0	4	6
241	R:R:I404	R:R:V400	1.54	No	No	0	9	8
242	R:R:H135	R:R:P136	1.53	No	No	0	7	9
243	R:R:H450	R:R:P451	1.53	Yes	Yes	1	9	9
244	R:R:L195	R:R:S199	1.5	No	No	0	6	6
245	R:R:L195	R:R:V198	1.49	No	No	0	6	7
246	R:R:L205	R:R:V409	1.49	No	No	0	7	7
247	R:R:L107	R:R:T111	1.47	No	No	0	7	9
248	R:R:I133	R:R:I134	1.47	No	Yes	0	8	8
249	R:R:D176	R:R:S183	1.47	Yes	No	0	4	5
250	R:R:D426	R:R:V425	1.46	No	No	0	4	7
251	R:R:G154	R:R:Y153	1.45	No	No	0	4	5
252	R:R:I160	R:R:L113	1.43	No	No	0	5	8
253	R:R:I201	R:R:L205	1.43	No	No	0	8	7
254	R:R:E428	R:R:V427	1.43	No	No	0	4	5
255	R:R:I438	R:R:L442	1.43	No	No	0	6	9
256	R:R:K142	R:R:L131	1.41	No	No	0	7	6
257	R:R:E428	R:R:T429	1.41	No	No	0	4	8
258	R:R:H102	R:R:S101	1.39	No	No	0	5	4
259	R:R:A115	R:R:F116	1.39	No	Yes	0	8	9
260	R:R:A115	R:R:F443	1.39	No	No	0	8	8
261	R:R:A397	R:R:F216	1.39	No	Yes	0	8	7
262	R:R:A398	R:R:F216	1.39	No	Yes	0	8	7
263	R:R:P98	R:R:W97	1.35	No	Yes	0	4	9
264	R:R:F175	R:R:T91	1.3	Yes	No	0	5	7
265	R:R:D467	R:R:E464	1.3	No	No	0	6	8
266	R:R:H135	R:R:L131	1.29	No	No	0	7	6
267	R:R:R146	R:R:T144	1.29	No	No	0	6	9
268	R:R:F41	R:R:I40	1.26	No	No	0	7	5
269	R:R:V453	R:R:Y452	1.26	No	No	0	9	7
270	R:R:V425	R:R:W424	1.23	No	No	0	7	6
271	R:R:F96	R:R:L95	1.22	No	No	0	4	5
272	R:R:F406	R:R:L410	1.22	No	No	0	6	5
273	R:R:F417	R:R:L421	1.22	No	No	0	7	6
274	R:R:L150	R:R:R146	1.21	No	No	0	4	6
275	R:R:L226	R:R:Y227	1.17	No	No	0	5	5
276	R:R:F216	R:R:R220	1.07	Yes	No	0	7	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:S35	2.395	4	0	6
2	R:R:S45	2.81	4	1	8
3	R:R:N49	5.706	5	1	9
4	R:R:L63	4.19	4	6	8
5	R:R:N67	4.38	4	6	9
6	R:R:F69	3.5125	4	0	8
7	R:R:L74	3.465	4	1	9
8	R:R:T76	2.3775	4	1	9
9	R:R:V84	2.565	4	8	9
10	R:R:W97	4.9625	4	3	9
11	R:R:F114	5.56	5	0	7
12	R:R:F116	7.29	4	0	9
13	R:R:S118	3.2675	4	1	9
14	R:R:I134	4.08	5	0	8
15	R:R:Y139	4.3125	4	7	9
16	R:R:M143	4.05	4	7	8
17	R:R:P166	5.12	4	2	8
18	R:R:W170	4.9225	4	2	7
19	R:R:F175	4.514	5	3	5
20	R:R:D176	2.44	4	0	4
21	R:R:M184	3.77	5	2	7
22	R:R:W186	7.37833	6	0	7
23	R:R:S189	2.625	4	2	7
24	R:R:Y192	5.874	5	2	8
25	R:R:F200	6.2275	4	0	8
26	R:R:P204	3.655	4	9	9
27	R:R:V207	1.6325	4	4	7
28	R:R:M208	2.6925	4	0	9
29	R:R:F216	1.905	4	0	7
30	R:R:Y408	2.855	4	9	9
31	R:R:L412	2.59	4	0	9
32	R:R:W441	12.7425	4	5	8
33	R:R:F444	2.4725	4	8	8
34	R:R:Q446	3.3475	4	1	9
35	R:R:H450	5.014	5	1	9
36	R:R:P451	2.825	4	1	9
37	R:R:H458	3.8925	4	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:G31	R:R:S92	11.1184	1.86	No	No	0	5	7
2	R:R:S35	R:R:S92	12.6745	3.26	Yes	No	0	6	7
3	R:R:S35	R:R:V89	18.7801	1.62	Yes	No	0	6	8
4	R:R:V39	R:R:V89	20.2768	1.6	No	No	0	5	8
5	R:R:I40	R:R:V39	21.7616	3.07	No	No	0	5	5
6	R:R:F41	R:R:I40	23.2345	1.26	No	No	0	7	5
7	R:R:F41	R:R:L445	24.6956	2.44	No	No	0	7	6
8	R:R:I449	R:R:L445	26.1448	4.28	No	No	0	7	6
9	R:R:I449	R:R:S411	32.6662	4.64	No	No	0	7	8
10	R:R:Q446	R:R:S411	34.0084	2.89	Yes	No	0	9	8
11	R:R:H450	R:R:Q446	56.5303	4.95	Yes	Yes	1	9	9
12	R:R:H450	R:R:P451	66.9537	1.53	Yes	Yes	1	9	9
13	R:R:N49	R:R:P451	24.6897	6.52	Yes	Yes	1	9	9
14	R:R:N49	R:R:S45	11.2847	2.98	Yes	Yes	1	9	8
15	R:R:I81	R:R:L42	12.7279	5.71	No	No	0	8	8
16	R:R:D77	R:R:P451	10.8452	1.61	No	Yes	1	9	9
17	R:R:L52	R:R:P451	36.8058	1.64	No	Yes	0	9	9
18	R:R:G455	R:R:L52	35.3982	1.71	No	No	0	8	9
19	R:R:I465	R:R:V55	13.108	6.14	No	No	0	8	9
20	R:R:I461	R:R:I465	16.2499	2.94	No	No	0	8	8
21	R:R:G455	R:R:I461	33.9787	1.76	No	No	0	8	8
22	R:R:H458	R:R:I461	17.5625	6.63	Yes	No	0	9	8
23	R:R:H458	R:R:L63	12.9061	2.57	Yes	Yes	0	9	8
24	R:R:Q446	R:R:S118	32.2563	2.89	Yes	Yes	1	9	9
25	R:R:S118	R:R:T76	49.1952	1.6	Yes	Yes	1	9	9
26	R:R:T76	R:R:W156	25.2064	3.64	Yes	No	1	9	9
27	R:R:N72	R:R:W156	23.9948	5.65	No	No	0	9	9
28	R:R:L152	R:R:N72	19.5284	12.36	No	No	0	9	9
29	R:R:F69	R:R:L152	18.0733	2.44	Yes	No	0	8	9
30	R:R:F69	R:R:L151	15.2343	2.44	Yes	No	0	8	8
31	R:R:L151	R:R:M143	12.2171	2.83	No	Yes	0	8	8
32	R:R:F114	R:R:T76	29.7203	2.59	Yes	Yes	0	7	9
33	R:R:F114	R:R:Q80	25.5627	9.37	Yes	No	0	7	8
34	R:R:Q80	R:R:V84	25.0342	2.87	No	Yes	0	8	9
35	R:R:T111	R:R:V84	22.5812	3.17	No	Yes	0	9	9
36	R:R:F444	R:R:V84	23.1336	2.62	Yes	Yes	8	8	9
37	R:R:F443	R:R:F444	23.2167	2.14	No	Yes	0	8	8
38	R:R:A115	R:R:F443	12.0627	1.39	No	No	0	8	8
39	R:R:A115	R:R:F116	12.5794	1.39	No	Yes	0	8	9
40	R:R:F116	R:R:F200	19.6175	11.79	Yes	Yes	0	9	8
41	R:R:F200	R:R:L412	65.4986	3.65	Yes	Yes	0	8	9
42	R:R:L412	R:R:Q446	100	2.66	Yes	Yes	0	9	9
43	R:R:F103	R:R:W87	16.6716	10.02	No	No	0	5	6
44	R:R:L107	R:R:W87	18.7029	3.42	No	No	0	7	6
45	R:R:L107	R:R:T111	20.5737	1.47	No	No	0	7	9
46	R:R:F103	R:R:L99	14.6285	8.53	No	No	0	5	7
47	R:R:F96	R:R:L99	12.5735	4.87	No	No	0	4	7
48	R:R:A180	R:R:D176	17.9011	1.54	No	Yes	0	3	4
49	R:R:D176	R:R:N179	13.2506	4.04	Yes	No	0	4	4
50	R:R:I436	R:R:N179	14.2306	7.08	No	No	0	6	4
51	R:R:I436	R:R:L418	15.068	2.85	No	No	0	6	7
52	R:R:I439	R:R:L418	16.3212	5.71	No	No	0	7	7
53	R:R:I439	R:R:P414	17.5863	1.69	No	No	0	7	9
54	R:R:G413	R:R:P414	26.3527	4.06	No	No	0	7	9
55	R:R:G413	R:R:L412	27.784	1.71	No	Yes	0	7	9
56	R:R:F200	R:R:S196	46.1543	5.28	Yes	No	0	8	8
57	R:R:S196	R:R:W186	45.3169	3.71	No	Yes	0	8	7
58	R:R:M184	R:R:W186	23.9354	8.14	Yes	Yes	0	7	7
59	R:R:W186	R:R:Y415	11.7895	4.82	Yes	No	0	7	9
60	R:R:L412	R:R:Y408	89.1133	2.34	Yes	Yes	0	9	9
61	R:R:P204	R:R:Y408	30.3914	4.17	Yes	Yes	9	9	9
62	R:R:H450	R:R:I122	10.958	5.3	Yes	No	0	9	9
63	R:R:P204	R:R:V123	22.0407	3.53	Yes	No	0	9	7
64	R:R:V123	R:R:V207	20.7697	1.6	No	Yes	0	7	7
65	R:R:M208	R:R:Y408	55.2889	2.39	Yes	Yes	0	9	9
66	R:R:M208	R:R:S126	42.3413	3.07	Yes	No	0	9	9
67	R:R:S126	R:R:V207	20.5975	1.62	No	Yes	4	9	7
68	R:R:S126	R:R:V127	20.5203	1.62	No	No	4	9	7
69	R:R:C211	R:R:V127	19.1958	1.71	No	No	4	8	7
70	R:R:C211	R:R:V207	38.4035	1.71	No	Yes	4	8	7
71	R:R:I134	R:R:Y130	49.4803	3.63	Yes	No	0	8	9
72	R:R:C211	R:R:Y130	53.5487	6.72	No	No	0	8	9
73	R:R:H135	R:R:I134	25.0817	10.61	No	Yes	0	7	8
74	R:R:H135	R:R:L131	16.7666	1.29	No	No	0	7	6
75	R:R:K142	R:R:L131	12.5913	1.41	No	No	0	7	6
76	R:R:M184	R:R:Y192	11.0471	4.79	Yes	Yes	2	7	8
77	R:R:F444	R:R:I440	16.6894	2.51	Yes	No	0	8	7
78	R:R:I440	R:R:L181	15.163	2.85	No	No	0	7	4
79	R:R:A422	R:R:W186	23.6028	2.59	No	Yes	0	5	7
80	R:R:M208	R:R:Y212	14.1652	2.39	Yes	No	0	9	9
81	R:R:A422	R:R:V427	22.112	1.7	No	No	0	5	5
82	R:R:E428	R:R:V427	14.48	1.43	No	No	0	4	5
83	R:R:E428	R:R:T429	12.918	1.41	No	No	0	4	8
84	R:R:D426	R:R:T429	11.3441	5.78	No	No	0	4	8
85	R:R:V453	R:R:Y452	10.0374	1.26	No	No	0	9	7
86	R:R:H450	R:R:S118	18.489	5.58	Yes	Yes	1	9	9
87	R:R:D176	R:R:L181	13.7079	2.71	Yes	No	0	4	4
88	R:R:F443	R:R:Y415	13.0665	9.28	No	No	0	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:R34	R:R:T437	2.59	5	No	No	6	6	2	2
R:R:R34	R:R:W441	3	5	No	Yes	6	8	2	1
R:R:V37	R:R:W441	8.58	0	No	Yes	5	8	2	1
R:R:T437	R:R:W441	7.28	5	No	Yes	6	8	2	1
R:R:W441	W:W:?1	32.11	5	Yes	No	8	0	1	0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
50.00	Single	8W8R	AA-14	8W8R-GPR101-AA-14-chim(NtGi1-Gs)/&β;1/&γ;2
14.29	Single	7F61	Cholesterol	7F61-H₃-PF-03654746-Cholesterol
14.29	Consensus	h3_on_allo	Other Ligand	7F61-H₃-PF-03654746-Cholesterol
12.50	Single	7XP6	Strychnine	7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
12.50	Consensus	class-t_on	Orthosteric Ligand	taste2_on
12.50	Consensus	gs_class-t	Orthosteric Ligand	gs_taste
12.50	Consensus	gs_taste	Orthosteric Ligand	7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
12.50	Consensus	taste2_on	Orthosteric Ligand	7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
11.11	Single	5U09	Taranabant	5U09-CB₁-Taranabant
10.00	Single	8K2W	AMG487	8K2W-CXCR3-AMG487
10.00	Single	8X7A	Treprostinil	8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
10.00	Consensus	cb1_off	Orthosteric Ligand	5TGZ-CB₁-AM6538 5U09-CB₁-Taranabant
9.09	Single	2Y01	Dobutamine	2Y01-β₁-Dobutamine
9.09	Single	5TGZ	AM6538	5TGZ-CB₁-AM6538
9.09	Single	6IIV	Daltroban	6IIV-TP-Daltroban
9.09	Consensus	lipid_off	Orthosteric Ligand	cannabinoid_off leuko_off lpl_off paf_off prostanoid_off
9.09	Consensus	prostanoid_off	Orthosteric Ligand	ep_off tp_off dp_off
9.09	Consensus	tp_off	Orthosteric Ligand	6IIV-TP-Daltroban 6IIU-TP-Ramatroban
8.33	Single	2Y00	Dobutamine	2Y00-β₁-Dobutamine
8.33	Single	4JKV	Taladegib (LY2940680)	4JKV-SMO-Taladegib (LY2940680)
8.33	Single	5T1A	PubChem 68764898; PubChem 12093170	5T1A-CCR2-PubChem 68764898; PubChem 12093170
8.33	Single	5YHL	PubChem 135121352	5YHL-EP₄-PubChem 135121352
8.33	Single	5YWY	ONO-AE3-208	5YWY-EP₄-ONO-AE3-208
8.33	Single	6GPX	MK0812	6GPX-CCR2-MK0812
8.33	Single	6M9T	Misoprostol-FA	6M9T-EP₃-Misoprostol-FA
8.33	Single	6XBK	Cholesterol	6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
8.33	Single	7YXA	ONO-5430608	7YXA-S1P₅-ONO-5430608
8.33	Single	8GD9	Rivenprost	8GD9-EP₄-Rivenprost-Gs/&β;1/&γ;2
8.33	Single	8GDA	L902688	8GDA-EP₄-L902688-Gs/&β;1/&γ;2
8.33	Single	8GDC	PGE2	8GDC-EP₃-PGE2-Gi1/&β;1/&γ;2
8.33	Consensus	ccr2_off_allo	Other Ligand	5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
8.33	Consensus	ep3_on	Orthosteric Ligand	8GDC-EP₃-PGE2-Gi1/&β;1/&γ;2
8.33	Consensus	ep4_off	Orthosteric Ligand	5YWY-EP₄-ONO-AE3-208 5YHL-EP₄-PubChem 135121352
8.33	Consensus	ep_off	Orthosteric Ligand	ep4_off
7.69	Single	3PDS	Hydroxybenzylisoproterenol	3PDS-β₂-Hydroxybenzylisoproterenol
7.69	Single	5V56	TC114	5V56-SMO-TC114
7.69	Single	5V57	TC114	5V57-SMO-TC114
7.69	Single	6O3C	Cholesterol	6O3C-SMO-SAG21k-Cholesterol
7.69	Single	7R0C	Acyclovir triphosphate	7R0C-V₂-Acyclovir triphosphate-Arrestin2
7.69	Single	8GDB	PGE2	8GDB-EP₄-PGE2-Gs/&β;1/&γ;2
7.69	Single	8IUK	PGF2-alpha	8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.69	Single	8X79	MRE-269	8X79-I2-MRE-269-Gs/&β;1/&γ;2
7.69	Single	8XJM	Latanoprost	8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
7.14	Single	4N4W	SANT-1	4N4W-SMO-SANT-1
7.14	Single	6AK3	Dinoprostone IPGE2	6AK3-EP₃-Dinoprostone IPGE2
7.14	Single	6H7N	(S)-Xamoterol	6H7N-β₁-(S)-Xamoterol
7.14	Single	6IIU	Ramatroban	6IIU-TP-Ramatroban
7.14	Single	7D7M	Dinoprostone	7D7M-EP₄-Dinoprostone-Gs/&β;1/&γ;1
7.14	Single	8GCP	PGE2	8GCP-EP₄-PGE2-Gi1/&β;1/&γ;2
7.14	Consensus	beta1_on	Orthosteric Ligand	7JJO-β₁-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β₁-Dobutamine-Gs/&β;1/&γ;2
7.14	Consensus	cannabinoid_off	Orthosteric Ligand	cb1_off cb2_off
7.14	Consensus	ep_on	Orthosteric Ligand	ep4_on ep2_on ep3_on
7.14	Consensus	gi_prostanoid	Orthosteric Ligand	8GCP-EP₄-PGE2-Gi1/&β;1/&γ;2 8GDC-EP₃-PGE2-Gi1/&β;1/&γ;2 8GCM-EP₄-L902688-Gi1/&β;1/&γ;2
7.14	Consensus	prostanoid_on	Orthosteric Ligand	ep_on fpa_on
6.67	Single	6H7L	Dobutamine	6H7L-β₁-Dobutamine
6.67	Single	7CX2	PGE2	7CX2-EP₂-PGE2-Gs/&β;1/&γ;2
6.67	Single	7CX4	Evatanepag	7CX4-EP₂-Evatanepag-Gs/&β;1/&γ;2
6.67	Single	7QVM	Oxytocin	7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
6.67	Single	8XJO	U46619	8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.67	Consensus	ep2_on	Orthosteric Ligand	7CX4-EP₂-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP₂-PGE2-Gs/&β;1/&γ;2 7CX3-EP₂-Taprenepag-Gs/&β;1/&γ;2
6.67	Consensus	ep4_on	Orthosteric Ligand	7D7M-EP₄-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP₄-PGE2-Gi1/&β;1/&γ;2 8GD9-EP₄-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP₄-L902688-Gs/&β;1/&γ;2
6.67	Consensus	fpa_on	Orthosteric Ligand	8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.67	Consensus	gs_lipid	Orthosteric Ligand	gs_ffa gs_prostanoid
6.67	Consensus	gs_prostanoid	Orthosteric Ligand	8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP₂-PGE2-Gs/&β;1/&γ;2 7CX3-EP₂-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP₄-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP₂-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.67	Consensus	ot_on	Orthosteric Ligand	7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
6.25	Single	7F2O	Bradykinin	7F2O-BK₂-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.25	Single	8IQ4	Carboprost	8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.25	Single	8IUM	Tafluprost acid	8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.25	Consensus	go_vasopressin	Orthosteric Ligand	7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
5.88	Single	4AMJ	(S)-Carvedilol	4AMJ-β₁-(S)-Carvedilol
5.88	Single	7CX3	Taprenepag	7CX3-EP₂-Taprenepag-Gs/&β;1/&γ;2
5.88	Single	8DCR	Dobutamine	8DCR-β₁-Dobutamine-Gs/&β;1/&γ;2
5.88	Consensus	ste2_off	Orthosteric Ligand	7QA8-STE2-Peptide
5.56	Consensus	vasopressin-ot_on	Orthosteric Ligand	ot_on v2_on
5.00	Single	7AD3	Alpha-factor mating pheromone	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
5.00	Consensus	bk2_on	Orthosteric Ligand	7F2O-BK₂-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
5.00	Consensus	class-d_on	Orthosteric Ligand	ste2_on
5.00	Consensus	gi_class-d	Orthosteric Ligand	gi_ste
5.00	Consensus	gi_ste	Orthosteric Ligand	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
5.00	Consensus	ste2_on	Orthosteric Ligand	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
4.76	Single	7F6H	Bradykinin	7F6H-BK₂-Bradykinin-Gq/&β;1/&γ;2
4.76	Single	7F6I	Kallidin	7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
4.76	Single	7KH0	Acyclovir triphosphate	7KH0-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
4.76	Single	7QBI	Alpha-factor mating pheromone	7QBI-STE2-Alpha-factor mating pheromone
4.76	Consensus	bk1_on	Orthosteric Ligand	7EIB-BK₁-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76	Consensus	gs_bradykinin	Orthosteric Ligand	7F2O-BK₂-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK₁-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.55	Single	7QBI	Alpha-factor mating pheromone	7QBI-STE2-Alpha-factor mating pheromone
4.55	Consensus	bradykinin_on	Orthosteric Ligand	bk2_on bk1_on
4.55	Consensus	class-d_on	Orthosteric Ligand	ste2_on
4.55	Consensus	gs_vasopressin-ot	Orthosteric Ligand	7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
4.35	Single	7AD3	Alpha-factor mating pheromone	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
4.35	Single	7EIB	Des-Arg10-Kallidin	7EIB-BK₁-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.35	Consensus	gi_class-d	Orthosteric Ligand	gi_ste
4.35	Consensus	gi_ste	Orthosteric Ligand	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
4.17	Consensus	gq_bradykinin	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F96	R:R:L99	4.87	No	No	4	7	1	2
R:R:F96	W:W:?2	9.36	No	No	4	0	1	0
R:R:N100	W:W:?2	14.08	No	No	8	0	1	0
R:R:F96	R:R:L95	1.22	No	No	4	5	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
66.67	Single	8W8R	AA-14	8W8R-GPR101-AA-14-chim(NtGi1-Gs)/&β;1/&γ;2
20.00	Single	8TLM	Anti-murine CCR8 antibody	8TLM-CCR8-Anti-murine CCR8 antibody
20.00	Consensus	ccr8_off	Orthosteric Ligand	8TLM-CCR8-Anti-murine CCR8 antibody
7.14	Single	7XBD	Galanin	7XBD-GAL₂-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.14	Single	7XJL	Spexin	7XJL-GAL₂-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.67	Single	4PY0	2MeSATP	4PY0-P2Y₁₂-2MeSATP
6.67	Single	7WQ4	Galanin	7WQ4-GAL₂-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.67	Single	7XJK	Galanin	7XJK-GAL₂-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.67	Single	7XXI	2MeSADP	7XXI-P2Y₁₂-2MeSADP-Gi2/&β;1/&γ;2
6.67	Consensus	galanin_on	Orthosteric Ligand	gal2_on gal1_on
6.25	Single	4PXZ	2MeSADP	4PXZ-P2Y₁₂-2MeSADP
6.25	Single	8HN1	Toxin AdTx1	8HN1-Alpha1A-Toxin AdTx1
6.25	Consensus	gal2_on	Orthosteric Ligand	7WQ4-GAL₂-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL₂-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.25	Consensus	gs_galanin	Orthosteric Ligand	7WQ4-GAL₂-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL₂-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.56	Single	7F4I	SHU9119	7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
5.56	Consensus	alpha1a_off	Orthosteric Ligand	7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
5.26	Single	8IOC	Gamma-MSH	8IOC-MC₃-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
5.26	Consensus	alpha1_off	Orthosteric Ligand	alpha1a_off alpha1b_off
5.00	Single	7F4D	Alpha-MSH	7F4D-MC₁-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
5.00	Consensus	mc3_on	Orthosteric Ligand	8IOC-MC₃-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
5.00	Consensus	mc5_on	Orthosteric Ligand	8INR-MC₅-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
4.76	Single	7DW9	Acyclovir triphosphate	7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
4.76	Consensus	v2_on	Orthosteric Ligand	7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Single	8IOD	PG-901	8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Consensus	gs_melanocortin	Orthosteric Ligand	7F4D-MC₁-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC₄-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC₄-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC₄-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC₄-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC₄-THIQ-Gs/&β;1/&γ;2
4.55	Consensus	mc1_on	Orthosteric Ligand	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC₁-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
4.35	Consensus	gi_neuromedin	Orthosteric Ligand	7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
4.17	Single	7F53	Alpha-MSH	7F53-MC₄-Alpha-MSH-Gs/&β;1/&γ;2
4.17	Single	7XK8	Neuromedin-U-25	7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
3.70	Single	8HBD	IRL1620	8HBD-ET_B-IRL1620-Gi1/&β;1/&γ;2
3.70	Consensus	melanocortin_on	Orthosteric Ligand	mc2_on mc1_on mc3_on mc4_on mc5_on
3.57	Single	6LRY	Sarafotoxin-B	6LRY-ET_B-Sarafotoxin-B
3.45	Consensus	mc2_on	Orthosteric Ligand	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1

PDB Summary
PDB	8W8S
Class	A
SubFamily	Orphan
Type	A orphans
SubType	GPR101
Species	Homo Sapiens
Ligand	-
Other Ligand(s)	AA-14
Protein Partners	-
PDB Resolution	3.3
Date	2024-01-03
D.O.I.	10.1038/s41589-023-01456-6

Net Summary
I_min	1.59
Number of Linked Nodes	252
Number of Links	276
Number of Hubs	37
Number of Links mediated by Hubs	130
Number of Communities	11
Number of Nodes involved in Communities	50
Number of Links involved in Communities	61

Path Summary
Number Of Nodes in MetaPath	89
Number Of Links MetaPath	88
Number of Shortest Paths	37953
Length Of Smallest Path	3
Average Path Length	13.387
Length of Longest Path	29
Minimum Path Strength	1.23
Average Path Strength	3.72053
Maximum Path Strength	20.345
Minimum Path Correlation	0.7
Average Path Correlation	0.929546
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.34783
Average % Of Corr. Nodes	53.8701
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	43.1515
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	U7D
PDB Residues	W:W:?1 W:W:?2
Environment Details	Open EMBL-EBI Page
Code	U7D
Name	1-(4-methylpyridin-2-yl)-3-[3-(trifluoromethyl)phenyl]thiourea
Synonyms	CHEMBL2134995
Identifier	1-(4-methylpyridin-2-yl)-3-[3-(trifluoromethyl)phenyl]thiourea
Formula	C14 H12 F3 N3 S
Molecular Weight	311.325
SMILES	Cc1ccnc(c1)NC(=S)Nc2cccc(c2)C(F)(F)F
PubChem	848971
Formal Charge	0
Total Atoms	33
Total Chiral Atoms	0
Total Bonds	34
Total Aromatic Bonds	12


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q96P66
Sequence	>8W8S_Chain_R S L A H G I I R S T V L V I F L A A S F V G N I V L A L V L Q R K P Q L L Q V T N R F I F N L L V T D L L Q I S L V A P W V V A T S V P L F W P L N S H F C T A L V S L T H L F A F A S V N T I V V V S V D R Y L S I I H P L S Y P S K M T Q R R G Y L L L Y G T W I V A I L Q S T P P L Y G W G Q A A F D E R N A L C S M I W G A S P S Y T I L S V V S F I V I P L I V M I A C Y S V V F C A A R R Q H A L L Y N C K A A K V I F I I I F S Y V L S L G P Y C F L A V L A V W V D V E T Q V P Q W V I T I I I W L F F L Q C C I H P Y V Y G Y M H K T I K K E I Q D M L K K F F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8W8Q	A	Orphan	A orphans	GPR101	Homo sapiens	-	-	Gs/&β;1/&γ;2	2.89	2024-01-03	10.1038/s41589-023-01456-6
	8W8R	A	Orphan	A orphans	GPR101	Homo sapiens	-	AA-14	chim(NtGi1-Gs)/&β;1/&γ;2	3.3	2024-01-03	10.1038/s41589-023-01456-6
	8W8S	A	Orphan	A orphans	GPR101	Homo sapiens	-	AA-14	-	3.3	2024-01-03	10.1038/s41589-023-01456-6

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