psnGPCR

Press and hold down the left mouse button and move the mouse to rotate.
Press and hold down the central mouse button and move the mouse to translate.
Use the mouse wheel to zoom in or out.
Click on any atom on your molecule and the corresponding residue label will be placed beneath the viewer.

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I32	R:R:L28	2.85	No	No	0	6	6
2	R:R:H30	R:R:T437	4.11	No	No	0	5	6
3	R:R:G31	R:R:S92	1.86	No	No	0	5	6
4	R:R:I32	R:R:S35	3.1	No	Yes	0	6	6
5	R:R:R34	R:R:T437	2.59	No	No	4	5	6
6	R:R:R34	R:R:W441	3	No	Yes	4	5	8
7	R:R:S35	R:R:V89	1.62	Yes	No	0	6	7
8	R:R:S35	R:R:S92	3.26	Yes	No	0	6	6
9	R:R:V37	R:R:W441	8.58	No	Yes	0	6	8
10	R:R:L38	R:R:L42	2.77	No	No	0	6	8
11	R:R:I40	R:R:V39	3.07	No	No	0	6	5
12	R:R:F41	R:R:L445	2.44	No	No	0	7	7
13	R:R:I81	R:R:L42	5.71	No	No	0	8	8
14	R:R:N49	R:R:S45	2.98	Yes	Yes	1	9	9
15	R:R:I81	R:R:S45	3.1	No	Yes	1	8	9
16	R:R:C447	R:R:S45	3.44	No	Yes	1	9	9
17	R:R:C448	R:R:S45	1.72	No	Yes	0	8	9
18	R:R:F46	R:R:I50	3.77	No	No	0	7	6
19	R:R:F46	R:R:L78	3.65	No	No	0	7	8
20	R:R:G48	R:R:V47	1.84	No	No	0	9	6
21	R:R:L74	R:R:N49	4.12	Yes	Yes	1	9	9
22	R:R:D77	R:R:N49	9.42	No	Yes	0	9	9
23	R:R:L78	R:R:N49	5.49	No	Yes	1	8	9
24	R:R:N49	R:R:P451	6.52	Yes	No	0	9	9
25	R:R:L52	R:R:P451	1.64	No	No	0	9	9
26	R:R:G455	R:R:L52	1.71	No	No	0	9	9
27	R:R:A53	R:R:L74	3.15	No	Yes	0	7	9
28	R:R:E464	R:R:V55	2.85	No	No	0	9	9
29	R:R:I465	R:R:V55	6.14	No	No	0	8	9
30	R:R:M468	R:R:V55	3.04	No	No	0	7	9
31	R:R:L56	R:R:N67	5.49	No	Yes	0	8	9
32	R:R:I70	R:R:L56	2.85	No	No	0	8	8
33	R:R:F71	R:R:Q57	3.51	No	No	0	8	4
34	R:R:K59	R:R:R58	3.71	No	No	0	7	8
35	R:R:K59	R:R:P60	1.67	No	No	0	7	8
36	R:R:E464	R:R:K59	9.45	No	No	0	9	7
37	R:R:L62	R:R:L63	5.54	No	Yes	5	9	8
38	R:R:L62	R:R:N67	6.87	No	Yes	5	9	9
39	R:R:L63	R:R:T66	5.9	Yes	No	0	8	8
40	R:R:L63	R:R:N67	2.75	Yes	Yes	5	8	9
41	R:R:H458	R:R:L63	2.57	Yes	Yes	0	9	8
42	R:R:M143	R:R:V65	3.04	Yes	No	0	8	7
43	R:R:Q145	R:R:V65	4.3	No	No	0	4	7
44	R:R:I70	R:R:T66	3.04	No	No	0	8	8
45	R:R:N67	R:R:R68	2.41	Yes	No	0	9	7
46	R:R:R68	R:R:Y149	3.09	No	No	0	7	4
47	R:R:F69	R:R:V124	6.55	Yes	No	0	8	8
48	R:R:F69	R:R:V125	2.62	Yes	No	0	8	9
49	R:R:F69	R:R:L151	2.44	Yes	No	0	8	8
50	R:R:F69	R:R:L152	2.44	Yes	No	0	8	9
51	R:R:F71	R:R:L74	2.44	No	Yes	0	8	9
52	R:R:F71	R:R:V75	5.24	No	No	0	8	7
53	R:R:N72	R:R:T121	8.77	No	No	0	9	9
54	R:R:L152	R:R:N72	12.36	No	No	0	9	9
55	R:R:N72	R:R:W156	5.65	No	No	0	9	9
56	R:R:L73	R:R:S118	3	No	No	3	9	9
57	R:R:H450	R:R:L73	7.71	Yes	No	3	9	9
58	R:R:L74	R:R:L78	4.15	Yes	No	1	9	8
59	R:R:F114	R:R:T76	2.59	Yes	No	0	6	9
60	R:R:A117	R:R:T76	1.68	No	No	7	9	9
61	R:R:T76	R:R:W156	3.64	No	No	7	9	9
62	R:R:C447	R:R:D77	7.78	No	No	0	9	9
63	R:R:F114	R:R:L79	4.87	Yes	No	0	6	7
64	R:R:Q80	R:R:V84	2.87	No	No	0	8	9
65	R:R:F114	R:R:Q80	9.37	Yes	No	0	6	8
66	R:R:C447	R:R:I81	6.55	No	No	1	9	8
67	R:R:L83	R:R:S82	6.01	No	No	0	6	5
68	R:R:L110	R:R:L83	2.77	No	No	0	6	6
69	R:R:T111	R:R:V84	3.17	No	No	0	9	9
70	R:R:F444	R:R:V84	2.62	Yes	No	0	8	9
71	R:R:A85	R:R:P86	1.87	No	No	0	8	9
72	R:R:F103	R:R:W87	10.02	No	No	0	6	6
73	R:R:L107	R:R:W87	3.42	No	No	0	7	6
74	R:R:F444	R:R:V88	2.62	Yes	No	0	8	8
75	R:R:P94	R:R:V93	5.3	No	No	0	6	6
76	R:R:L95	R:R:V93	4.47	No	No	0	6	6
77	R:R:F96	R:R:L99	4.87	No	No	0	4	7
78	R:R:F96	W:W:?2	9.36	No	No	0	4	0
79	R:R:F175	R:R:W97	5.01	Yes	Yes	8	5	9
80	R:R:E177	R:R:W97	8.72	No	Yes	0	4	9
81	R:R:A180	R:R:W97	2.59	No	Yes	8	4	9
82	R:R:F103	R:R:L99	8.53	No	No	0	6	7
83	R:R:N100	W:W:?2	14.08	No	No	0	8	0
84	R:R:C104	R:R:C182	7.28	No	No	0	9	9
85	R:R:A173	R:R:T105	1.68	No	No	0	5	7
86	R:R:H112	R:R:V108	6.92	No	No	0	8	7
87	R:R:S109	R:R:T164	3.2	No	No	0	8	7
88	R:R:L167	R:R:S109	7.51	No	No	0	8	8
89	R:R:F114	R:R:L110	8.53	Yes	No	0	6	6
90	R:R:H112	R:R:M184	2.63	No	Yes	0	8	7
91	R:R:H112	R:R:Y415	4.36	No	No	0	8	9
92	R:R:F114	R:R:L113	2.44	Yes	No	0	6	8
93	R:R:F116	R:R:Q162	9.37	Yes	No	0	9	8
94	R:R:F116	R:R:S163	6.61	Yes	No	0	9	8
95	R:R:F116	R:R:F200	11.79	Yes	Yes	0	9	8
96	R:R:A117	R:R:W156	3.89	No	No	7	9	9
97	R:R:A117	R:R:A159	1.79	No	No	0	9	9
98	R:R:Q446	R:R:S118	2.89	Yes	No	3	9	9
99	R:R:H450	R:R:S118	5.58	Yes	No	3	9	9
100	R:R:N120	R:R:V119	2.96	No	No	0	8	9
101	R:R:P204	R:R:V119	3.53	Yes	No	9	9	9
102	R:R:V119	R:R:Y408	2.52	No	Yes	9	9	9
103	R:R:N120	R:R:T155	5.85	No	No	0	8	8
104	R:R:N120	R:R:V158	2.96	No	No	0	8	5
105	R:R:H450	R:R:I122	5.3	Yes	No	0	9	8
106	R:R:I122	R:R:Y454	7.25	No	No	0	8	9
107	R:R:P204	R:R:V123	3.53	Yes	No	0	9	7
108	R:R:S126	R:R:V127	1.62	No	No	0	9	7
109	R:R:S126	R:R:V207	1.62	No	No	0	9	7
110	R:R:M208	R:R:S126	3.07	Yes	No	0	9	9
111	R:R:C211	R:R:V127	1.71	No	No	0	8	7
112	R:R:D128	R:R:Y139	5.75	No	Yes	6	9	8
113	R:R:D128	R:R:M143	5.54	No	Yes	6	9	8
114	R:R:H458	R:R:R129	2.26	Yes	No	0	9	9
115	R:R:I134	R:R:Y130	3.63	Yes	No	0	8	8
116	R:R:C211	R:R:Y130	6.72	No	No	0	8	8
117	R:R:S132	R:R:Y139	2.54	No	Yes	0	8	8
118	R:R:I133	R:R:V215	9.22	No	No	0	8	9
119	R:R:H135	R:R:I134	10.61	No	Yes	0	7	8
120	R:R:I134	R:R:V214	3.07	Yes	No	0	8	7
121	R:R:A218	R:R:I134	1.62	No	Yes	0	7	8
122	R:R:S138	R:R:S141	3.26	No	No	0	6	5
123	R:R:K142	R:R:S138	4.59	No	No	0	6	6
124	R:R:P140	R:R:Y139	4.17	No	Yes	0	7	8
125	R:R:M143	R:R:Y139	4.79	Yes	Yes	6	8	8
126	R:R:L151	R:R:M143	2.83	No	Yes	0	8	8
127	R:R:R147	R:R:T144	3.88	No	No	0	8	9
128	R:R:G148	R:R:L151	1.71	No	No	0	8	8
129	R:R:G154	R:R:I157	1.76	No	No	0	5	5
130	R:R:Q162	R:R:V158	2.87	No	No	0	8	5
131	R:R:S163	R:R:T164	4.8	No	No	0	8	7
132	R:R:P165	R:R:P166	7.79	No	Yes	2	9	8
133	R:R:P165	R:R:W170	6.76	No	Yes	2	9	6
134	R:R:P165	R:R:Y192	8.34	No	Yes	2	9	8
135	R:R:G171	R:R:P166	4.06	No	Yes	0	7	8
136	R:R:M184	R:R:P166	1.68	Yes	Yes	2	7	8
137	R:R:P166	R:R:Y192	6.95	Yes	Yes	2	8	8
138	R:R:G169	R:R:Y168	2.9	No	No	0	7	6
139	R:R:S189	R:R:W170	2.47	Yes	Yes	2	6	6
140	R:R:S191	R:R:W170	3.71	No	Yes	0	6	6
141	R:R:W170	R:R:Y192	6.75	Yes	Yes	2	6	8
142	R:R:G171	R:R:S189	3.71	No	Yes	0	7	6
143	R:R:I185	R:R:Q172	2.74	No	No	0	7	6
144	R:R:A188	R:R:Q172	4.55	No	No	0	5	6
145	R:R:A180	R:R:F175	5.55	No	Yes	8	4	5
146	R:R:C182	R:R:F175	8.38	No	Yes	0	9	5
147	R:R:D176	R:R:N179	4.04	Yes	No	0	5	4
148	R:R:D176	R:R:L181	2.71	Yes	No	0	5	4
149	R:R:D176	R:R:E428	5.2	Yes	No	0	5	4
150	R:R:N179	R:R:R178	4.82	No	No	0	4	3
151	R:R:E428	R:R:R178	2.33	No	No	0	4	3
152	R:R:Q433	R:R:R178	4.67	No	No	0	4	3
153	R:R:I436	R:R:N179	7.08	No	No	0	5	4
154	R:R:I440	R:R:L181	2.85	No	No	0	8	4
155	R:R:M184	R:R:W186	8.14	Yes	Yes	0	7	7
156	R:R:M184	R:R:Y192	4.79	Yes	Yes	2	7	8
157	R:R:T193	R:R:W186	13.34	No	Yes	0	8	7
158	R:R:S196	R:R:W186	3.71	No	Yes	0	8	7
159	R:R:W186	R:R:Y415	4.82	Yes	No	0	7	9
160	R:R:A419	R:R:W186	11.67	No	Yes	0	8	7
161	R:R:A422	R:R:W186	2.59	No	Yes	0	5	7
162	R:R:P190	R:R:S189	1.78	No	Yes	0	5	6
163	R:R:S189	R:R:Y192	2.54	Yes	Yes	2	6	8
164	R:R:F200	R:R:S196	5.28	Yes	No	0	8	8
165	R:R:V198	R:R:V202	3.21	No	No	0	6	6
166	R:R:F200	R:R:L412	3.65	Yes	Yes	0	8	9
167	R:R:C416	R:R:F200	4.19	No	Yes	0	8	8
168	R:R:C416	R:R:I201	3.27	No	No	0	8	8
169	R:R:I203	R:R:P204	3.39	No	Yes	0	6	9
170	R:R:P204	R:R:Y408	4.17	Yes	Yes	9	9	9
171	R:R:C211	R:R:V207	1.71	No	No	0	8	7
172	R:R:M208	R:R:Y212	2.39	Yes	No	0	9	9
173	R:R:I405	R:R:M208	2.92	No	Yes	0	8	9
174	R:R:M208	R:R:Y408	2.39	Yes	Yes	0	9	9
175	R:R:I401	R:R:Y212	3.63	No	No	0	9	9
176	R:R:I404	R:R:Y212	2.42	No	No	0	9	9
177	R:R:S213	R:R:V214	3.23	No	No	0	4	7
178	R:R:F216	R:R:I401	3.77	Yes	No	0	7	9
179	R:R:A219	R:R:A397	1.79	No	No	0	8	8
180	R:R:L225	R:R:R221	4.86	No	No	0	5	5
181	R:R:H223	R:R:Y227	9.8	No	No	0	6	4
182	R:R:I449	R:R:S407	3.1	No	No	0	7	7
183	R:R:S407	R:R:V453	3.23	No	No	0	7	9
184	R:R:L412	R:R:Y408	2.34	Yes	Yes	0	9	9
185	R:R:L410	R:R:L442	5.54	No	No	0	5	9
186	R:R:Q446	R:R:S411	2.89	Yes	No	0	9	9
187	R:R:I449	R:R:S411	4.64	No	No	0	7	9
188	R:R:G413	R:R:L412	1.71	No	Yes	0	7	9
189	R:R:L412	R:R:Q446	2.66	Yes	Yes	0	9	9
190	R:R:G413	R:R:P414	4.06	No	No	0	7	9
191	R:R:I439	R:R:P414	1.69	No	No	0	7	9
192	R:R:L442	R:R:P414	1.64	No	No	0	9	9
193	R:R:F443	R:R:Y415	9.28	No	No	0	8	9
194	R:R:I436	R:R:L418	2.85	No	No	0	5	6
195	R:R:I439	R:R:L418	5.71	No	No	0	7	6
196	R:R:L421	R:R:V425	2.98	No	No	0	7	8
197	R:R:A422	R:R:V427	1.7	No	No	0	5	4
198	R:R:V423	R:R:W424	8.58	No	No	0	8	7
199	R:R:D426	R:R:E428	5.2	No	No	0	7	4
200	R:R:D426	R:R:T429	5.78	No	No	0	7	8
201	R:R:V427	R:R:V431	4.81	No	No	0	4	6
202	R:R:P432	R:R:V431	3.53	No	No	10	7	6
203	R:R:V431	R:R:V435	3.21	No	No	10	6	5
204	R:R:P432	R:R:W434	8.11	No	No	0	7	4
205	R:R:P432	R:R:V435	5.3	No	No	10	7	5
206	R:R:T437	R:R:W441	7.28	No	Yes	4	6	8
207	R:R:F444	R:R:I440	2.51	Yes	No	0	8	8
208	R:R:W441	W:W:?1	32.11	Yes	No	0	8	0
209	R:R:F443	R:R:F444	2.14	No	Yes	0	8	8
210	R:R:I449	R:R:L445	4.28	No	No	0	7	7
211	R:R:H450	R:R:Q446	4.95	Yes	Yes	3	9	9
212	R:R:Y452	R:R:Y456	6.95	No	No	0	7	7
213	R:R:V453	R:R:Y454	7.57	No	No	0	9	9
214	R:R:G455	R:R:I461	1.76	No	No	0	9	8
215	R:R:K462	R:R:Y456	3.58	No	No	11	9	7
216	R:R:Q466	R:R:Y456	3.38	No	No	11	7	7
217	R:R:H458	R:R:T460	4.11	Yes	No	0	9	8
218	R:R:H458	R:R:I461	6.63	Yes	No	0	9	8
219	R:R:I461	R:R:I465	2.94	No	No	0	8	8
220	R:R:K462	R:R:Q466	2.71	No	No	11	9	7
221	R:R:A173	R:R:M184	1.61	No	Yes	0	5	7
222	R:R:S35	R:R:T36	1.6	Yes	No	0	6	5
223	R:R:V39	R:R:V89	1.6	No	No	0	5	7
224	R:R:S101	R:R:T105	1.6	No	No	0	4	7
225	R:R:V197	R:R:V420	1.6	No	No	0	8	7
226	R:R:G31	R:R:H30	1.59	No	No	0	5	5
227	R:R:T193	R:R:V197	1.59	No	No	0	8	8
228	R:R:A85	R:R:L42	1.58	No	No	0	8	8
229	R:R:P140	R:R:Q64	1.58	No	No	0	7	8
230	R:R:I465	R:R:V51	1.54	No	No	0	8	8
231	R:R:A180	R:R:D176	1.54	No	Yes	0	4	5
232	R:R:I203	R:R:V198	1.54	No	No	0	6	6
233	R:R:I206	R:R:V202	1.54	No	No	0	4	6
234	R:R:I404	R:R:V400	1.54	No	No	0	9	9
235	R:R:H135	R:R:P136	1.53	No	No	0	7	9
236	R:R:H450	R:R:P451	1.53	Yes	No	0	9	9
237	R:R:L195	R:R:S199	1.5	No	No	0	6	7
238	R:R:L195	R:R:V198	1.49	No	No	0	6	6
239	R:R:L205	R:R:V409	1.49	No	No	0	7	7
240	R:R:L107	R:R:T111	1.47	No	No	0	7	9
241	R:R:I133	R:R:I134	1.47	No	Yes	0	8	8
242	R:R:D176	R:R:S183	1.47	Yes	No	0	5	4
243	R:R:G154	R:R:Y153	1.45	No	No	0	5	6
244	R:R:I160	R:R:L113	1.43	No	No	0	5	8
245	R:R:I157	R:R:L161	1.43	No	No	0	5	6
246	R:R:I160	R:R:L161	1.43	No	No	0	5	6
247	R:R:I201	R:R:L205	1.43	No	No	0	8	7
248	R:R:I438	R:R:L442	1.43	No	No	0	6	9
249	R:R:Q430	R:R:T429	1.42	No	No	0	1	8
250	R:R:K142	R:R:L131	1.41	No	No	0	6	6
251	R:R:H102	R:R:S101	1.39	No	No	0	5	4
252	R:R:A115	R:R:F116	1.39	No	Yes	0	8	9
253	R:R:A115	R:R:F443	1.39	No	No	0	8	8
254	R:R:A397	R:R:F216	1.39	No	Yes	0	8	7
255	R:R:A398	R:R:F216	1.39	No	Yes	0	8	7
256	R:R:P98	R:R:W97	1.35	No	Yes	0	4	9
257	R:R:F175	R:R:T91	1.3	Yes	No	0	5	7
258	R:R:D467	R:R:E464	1.3	No	No	0	6	9
259	R:R:H135	R:R:L131	1.29	No	No	0	7	6
260	R:R:R146	R:R:T144	1.29	No	No	0	6	9
261	R:R:F41	R:R:I40	1.26	No	No	0	7	6
262	R:R:V453	R:R:Y452	1.26	No	No	0	9	7
263	R:R:V425	R:R:W424	1.23	No	No	0	8	7
264	R:R:F96	R:R:L95	1.22	No	No	0	4	6
265	R:R:F417	R:R:L421	1.22	No	No	0	7	7
266	R:R:L150	R:R:R146	1.21	No	No	0	4	6
267	R:R:L226	R:R:Y227	1.17	No	No	0	5	4
268	R:R:F216	R:R:R220	1.07	Yes	No	0	7	7
269	R:R:F402	R:R:F406	1.07	No	No	0	7	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:S35	2.395	4	0	6
2	R:R:S45	2.81	4	1	9
3	R:R:N49	5.706	5	1	9
4	R:R:L63	4.19	4	5	8
5	R:R:N67	4.38	4	5	9
6	R:R:F69	3.5125	4	0	8
7	R:R:L74	3.465	4	1	9
8	R:R:W97	4.4175	4	8	9
9	R:R:F114	5.56	5	0	6
10	R:R:F116	7.29	4	0	9
11	R:R:I134	4.08	5	0	8
12	R:R:Y139	4.3125	4	6	8
13	R:R:M143	4.05	4	6	8
14	R:R:P166	5.12	4	2	8
15	R:R:W170	4.9225	4	2	6
16	R:R:F175	5.06	4	8	5
17	R:R:D176	2.992	5	0	5
18	R:R:M184	3.77	5	2	7
19	R:R:W186	7.37833	6	0	7
20	R:R:S189	2.625	4	2	6
21	R:R:Y192	5.874	5	2	8
22	R:R:F200	6.2275	4	0	8
23	R:R:P204	3.655	4	9	9
24	R:R:M208	2.6925	4	0	9
25	R:R:F216	1.905	4	0	7
26	R:R:Y408	2.855	4	9	9
27	R:R:L412	2.59	4	0	9
28	R:R:W441	12.7425	4	4	8
29	R:R:F444	2.4725	4	0	8
30	R:R:Q446	3.3475	4	3	9
31	R:R:H450	5.014	5	3	9
32	R:R:H458	3.8925	4	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:G31	R:R:H30	10.3862	1.59	No	No	0	5	5
2	R:R:G31	R:R:S92	12.0878	1.86	No	No	0	5	6
3	R:R:S35	R:R:S92	13.7753	3.26	Yes	No	0	6	6
4	R:R:S35	R:R:V89	20.3841	1.62	Yes	No	0	6	7
5	R:R:V39	R:R:V89	22.001	1.6	No	No	0	5	7
6	R:R:I40	R:R:V39	23.6038	3.07	No	No	0	6	5
7	R:R:F41	R:R:I40	25.1924	1.26	No	No	0	7	6
8	R:R:F41	R:R:L445	26.7669	2.44	No	No	0	7	7
9	R:R:I449	R:R:L445	28.3273	4.28	No	No	0	7	7
10	R:R:I449	R:R:S411	36.7507	4.64	No	No	0	7	9
11	R:R:Q446	R:R:S411	38.184	2.89	Yes	No	0	9	9
12	R:R:H450	R:R:Q446	71.7998	4.95	Yes	Yes	3	9	9
13	R:R:H450	R:R:P451	63.3905	1.53	Yes	No	0	9	9
14	R:R:N49	R:R:P451	31.2646	6.52	Yes	No	0	9	9
15	R:R:N49	R:R:S45	13.733	2.98	Yes	Yes	1	9	9
16	R:R:L52	R:R:P451	37.0614	1.64	No	No	0	9	9
17	R:R:G455	R:R:L52	35.5927	1.71	No	No	0	9	9
18	R:R:I465	R:R:V55	12.1514	6.14	No	No	0	8	9
19	R:R:I461	R:R:I465	15.4769	2.94	No	No	0	8	8
20	R:R:G455	R:R:I461	34.11	1.76	No	No	0	9	8
21	R:R:H458	R:R:I461	18.4848	6.63	Yes	No	0	9	8
22	R:R:H458	R:R:L63	13.6059	2.57	Yes	Yes	0	9	8
23	R:R:L412	R:R:Q446	100	2.66	Yes	Yes	0	9	9
24	R:R:F200	R:R:L412	90.9977	3.65	Yes	Yes	0	8	9
25	R:R:F116	R:R:F200	59.0976	11.79	Yes	Yes	0	9	8
26	R:R:A115	R:R:F116	55.4473	1.39	No	Yes	0	8	9
27	R:R:A115	R:R:F443	55.1296	1.39	No	No	0	8	8
28	R:R:F443	R:R:F444	74.5464	2.14	No	Yes	0	8	8
29	R:R:F444	R:R:V84	69.1379	2.62	Yes	No	0	8	9
30	R:R:Q80	R:R:V84	52.969	2.87	No	No	0	8	9
31	R:R:F114	R:R:Q80	51.5216	9.37	Yes	No	0	6	8
32	R:R:F114	R:R:T76	34.6678	2.59	Yes	No	0	6	9
33	R:R:T76	R:R:W156	29.5347	3.64	No	No	7	9	9
34	R:R:N72	R:R:W156	28.1155	5.65	No	No	0	9	9
35	R:R:L152	R:R:N72	24.7476	12.36	No	No	0	9	9
36	R:R:F69	R:R:L152	23.0389	2.44	Yes	No	0	8	9
37	R:R:F69	R:R:L151	17.8281	2.44	Yes	No	0	8	8
38	R:R:L151	R:R:M143	14.2837	2.83	No	Yes	0	8	8
39	R:R:T111	R:R:V84	19.8122	3.17	No	No	0	9	9
40	R:R:F103	R:R:W87	14.6791	10.02	No	No	0	6	6
41	R:R:L107	R:R:W87	16.4513	3.42	No	No	0	7	6
42	R:R:L107	R:R:T111	18.0682	1.47	No	No	0	7	9
43	R:R:F103	R:R:L99	12.8927	8.53	No	No	0	6	7
44	R:R:F96	R:R:L99	11.0923	4.87	No	No	0	4	7
45	R:R:A180	R:R:D176	14.6226	1.54	No	Yes	0	4	5
46	R:R:D176	R:R:N179	17.6657	4.04	Yes	No	0	5	4
47	R:R:I436	R:R:N179	22.4458	7.08	No	No	0	5	4
48	R:R:I436	R:R:L418	22.9259	2.85	No	No	0	5	6
49	R:R:I439	R:R:L418	23.7591	5.71	No	No	0	7	6
50	R:R:I439	R:R:P414	24.5711	1.69	No	No	0	7	9
51	R:R:G413	R:R:P414	30.2761	4.06	No	No	0	7	9
52	R:R:G413	R:R:L412	31.6811	1.71	No	Yes	0	7	9
53	R:R:M184	R:R:W186	25.849	8.14	Yes	Yes	0	7	7
54	R:R:S196	R:R:W186	33.2698	3.71	No	Yes	0	8	7
55	R:R:F200	R:R:S196	33.7287	5.28	Yes	No	0	8	8
56	R:R:H112	R:R:Y415	10.1532	4.36	No	No	0	8	9
57	R:R:W186	R:R:Y415	16.1124	4.82	Yes	No	0	7	9
58	R:R:F114	R:R:L113	11.0923	2.44	Yes	No	0	6	8
59	R:R:L412	R:R:Y408	76.0785	2.34	Yes	Yes	0	9	9
60	R:R:P204	R:R:Y408	13.7753	4.17	Yes	Yes	9	9	9
61	R:R:H450	R:R:I122	11.4665	5.3	Yes	No	0	9	8
62	R:R:M208	R:R:Y408	63.6447	2.39	Yes	Yes	0	9	9
63	R:R:M208	R:R:S126	49.481	3.07	Yes	No	0	9	9
64	R:R:S126	R:R:V127	24.0486	1.62	No	No	0	9	7
65	R:R:S126	R:R:V207	24.0486	1.62	No	No	0	9	7
66	R:R:C211	R:R:V127	22.5376	1.71	No	No	0	8	7
67	R:R:C211	R:R:V207	22.5376	1.71	No	No	0	8	7
68	R:R:I134	R:R:Y130	38.77	3.63	Yes	No	0	8	8
69	R:R:C211	R:R:Y130	41.9261	6.72	No	No	0	8	8
70	R:R:H135	R:R:I134	19.7345	10.61	No	Yes	0	7	8
71	R:R:H135	R:R:L131	13.2105	1.29	No	No	0	7	6
72	R:R:M184	R:R:Y192	13.4082	4.79	Yes	Yes	2	7	8
73	R:R:F444	R:R:I440	18.4495	2.51	Yes	No	0	8	8
74	R:R:I440	R:R:L181	16.9385	2.85	No	No	0	8	4
75	R:R:A422	R:R:W186	10.6686	2.59	No	Yes	0	5	7
76	R:R:I203	R:R:P204	10.6263	3.39	No	Yes	0	6	9
77	R:R:M208	R:R:Y212	15.7029	2.39	Yes	No	0	9	9
78	R:R:I401	R:R:Y212	10.5557	3.63	No	No	0	9	9
79	R:R:V453	R:R:Y452	11.8548	1.26	No	No	0	9	7
80	R:R:D176	R:R:L181	15.4769	2.71	Yes	No	0	5	4
81	R:R:F443	R:R:Y415	21.2949	9.28	No	No	0	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:R34	R:R:T437	2.59	4	No	No	5	6	2	2
R:R:R34	R:R:W441	3	4	No	Yes	5	8	2	1
R:R:V37	R:R:W441	8.58	0	No	Yes	6	8	2	1
R:R:T437	R:R:W441	7.28	4	No	Yes	6	8	2	1
R:R:W441	W:W:?1	32.11	4	Yes	No	8	0	1	0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
50.00	Single	8W8R	AA-14	8W8R-GPR101-AA-14-chim(NtGi1-Gs)/β1/γ2
14.29	Single	7F61	Cholesterol	7F61-H₃-PF-03654746-Cholesterol
12.50	Single	9B9Y	7DY	9B9Y-CB₁-7DY
11.11	Single	5U09	Taranabant	5U09-CB₁-Taranabant
11.11	Single	9BA0	A1AKN	9BA0-CB₁-A1AKN
10.00	Single	8K2W	AMG487	8K2W-CXCR3-AMG487
10.00	Single	8X7A	Treprostinil	8X7A-I2-Treprostinil-Gs/β1/γ2
10.00	Consensus	cb1_off	Orthosteric Ligand	5U09-CB₁-Taranabant 5TGZ-CB₁-AM6538
10.00	Consensus	cxcr3_off	Orthosteric Ligand	8K2W-CXCR3-AMG487
9.09	Single	2Y01	Dobutamine	2Y01-β₁-Dobutamine
9.09	Single	5TGZ	AM6538	5TGZ-CB₁-AM6538
9.09	Single	6IIV	Daltroban	6IIV-TP-Daltroban
9.09	Single	7YXA	ONO-5430608	7YXA-S1P₅-ONO-5430608
9.09	Single	9B9Z	A1AKO	9B9Z-CB₁-A1AKO
9.09	Consensus	lipid_off	Orthosteric Ligand	cannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
8.33	Single	2Y00	Dobutamine	2Y00-β₁-Dobutamine
8.33	Single	4JKV	Taladegib	4JKV-SMO-Taladegib
8.33	Single	5T1A	PubChem 68764898; PubChem 12093170	5T1A-CCR2-PubChem 68764898; PubChem 12093170
8.33	Single	5YHL	PubChem 135121352	5YHL-EP₄-PubChem 135121352
8.33	Single	5YWY	ONO-AE3-208	5YWY-EP₄-ONO-AE3-208
8.33	Single	6GPX	MK0812	6GPX-CCR2-MK0812
8.33	Single	6M9T	Misoprostol-FA	6M9T-EP₃-Misoprostol-FA
8.33	Single	6XBK	Cholesterol	6XBK-SMO-Cholesterol-Gi1/β1/γ2
8.33	Single	8GD9	Rivenprost	8GD9-EP₄-Rivenprost-Gs/β1/γ2
8.33	Single	8GDC	PGE2	8GDC-EP₃-PGE2-Gi1/β1/γ2
8.33	Consensus	ep4_off	Orthosteric Ligand	5YWY-EP₄-ONO-AE3-208 5YHL-EP₄-PubChem 135121352
8.33	Consensus	ep_off	Orthosteric Ligand	ep4_off
8.33	Consensus	s1p5_off	Orthosteric Ligand	7YXA-S1P₅-ONO-5430608
7.69	Single	3PDS	Hydroxybenzylisoproterenol	3PDS-β₂-Hydroxybenzylisoproterenol
7.69	Single	5V56	TC114	5V56-SMO-TC114
7.69	Single	5V57	TC114	5V57-SMO-TC114
7.69	Single	6O3C	Cholesterol	6O3C-SMO-SAG21k-Cholesterol
7.69	Single	7R0C	AVP	7R0C-V₂-AVP-Arrestin2
7.69	Single	8GDB	PGE2	8GDB-EP₄-PGE2-Gs/β1/γ2
7.69	Single	8IUK	PGF2-alpha	8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69	Single	8X79	MRE-269	8X79-I2-MRE-269-Gs/β1/γ2
7.69	Single	8XJM	Latanoprost	8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
7.69	Single	9BJK	NAM	9BJK-μ-Naloxone-NAM
7.14	Single	4N4W	SANT-1	4N4W-SMO-SANT-1
7.14	Single	6AK3	Dinoprostone IPGE2	6AK3-EP₃-Dinoprostone IPGE2
7.14	Single	6H7N	S-Xamoterol	6H7N-β₁-S-Xamoterol
7.14	Single	6IIU	Ramatroban	6IIU-TP-Ramatroban
7.14	Single	8GCP	PGE2	8GCP-EP₄-PGE2-Gi1/β1/γ2
7.14	Single	8XJN	Cloprosetnol	8XJN-TP-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14	Consensus	cannabinoid_off	Orthosteric Ligand	cb2_off cb1_off
7.14	Consensus	lipid_offon	Orthosteric Ligand	lipid_off lipid_on
7.14	Consensus	lipid_offon_gp	Orthosteric Ligand	lipid_on_gp lipid_off
6.67	Single	6H7L	Dobutamine	6H7L-β₁-Dobutamine
6.67	Single	7CX4	Evatanepag	7CX4-EP₂-Evatanepag-Gs/β1/γ2
6.67	Single	7D7M	Dinoprostone	7D7M-EP₄-Dinoprostone-Gs/β1/γ1
6.67	Single	7QVM	Oxytocin	7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
6.67	Single	8XJK	Cloprosetnol	8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67	Single	8XJO	U46619	8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67	Consensus	beta1_on	Orthosteric Ligand	8DCR-β₁-Dobutamine-Gs/β1/γ2 7S0F-β₁-Isoprenaline-Gi1/β1/γ2
6.67	Consensus	beta1_on_gp	Orthosteric Ligand	8DCR-β₁-Dobutamine-Gs/β1/γ2 7S0F-β₁-Isoprenaline-Gi1/β1/γ2
6.67	Consensus	fp-alpha_on_gp	Orthosteric Ligand	8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67	Consensus	prostanoid_off	Orthosteric Ligand	ep_off dp_off
6.67	Consensus	prostanoid_on	Orthosteric Ligand	tp_on fp-alpha_on
6.67	Consensus	prostanoid_on_gp	Orthosteric Ligand	tp_on_gp fp-alpha_on_gp
6.67	Consensus	tp_on	Orthosteric Ligand	8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67	Consensus	tp_on_gp	Orthosteric Ligand	8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25	Single	7CX2	PGE2	7CX2-EP₂-PGE2-Gs/β1/γ2
6.25	Single	7F2O	Bradykinin	7F2O-BK₂-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25	Single	8GDA	L902688	8GDA-EP₄-L902688-Gs/β1/γ2
6.25	Single	8IQ4	Carboprost	8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25	Single	8IUM	Tafluprost acid	8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88	Single	4AMJ	S-Carvedilol	4AMJ-β₁-S-Carvedilol
5.88	Single	7CX3	Taprenepag	7CX3-EP₂-Taprenepag-Gs/β1/γ2
5.88	Single	8DCR	Dobutamine	8DCR-β₁-Dobutamine-Gs/β1/γ2
5.88	Single	8FYL	Vilazodone	8FYL-5-HT_1A-Vilazodone-Gi1/β1/γ1
5.00	Single	7AD3	Alpha-factor mating pheromone	7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
5.00	Single	7KH0	AVP	7KH0-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
4.76	Single	7F6H	Bradykinin	7F6H-BK₂-Bradykinin-Gq/β1/γ2
4.76	Single	7F6I	Kallidin	7F6I-BK₂-Kallidin-Gq/β1/γ2
4.76	Single	7QBI	Alpha-factor mating pheromone	7QBI-STE2-α-factor mating pheromone
4.55	Single	7QBI	Alpha-factor mating pheromone	7QBI-STE2-α-factor mating pheromone
4.35	Single	7AD3	Alpha-factor mating pheromone	7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
4.35	Single	7EIB	Des-Arg10-Kallidin	7EIB-BK₁-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17	Consensus	bk2_on	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/β1/γ2 7F6I-BK₂-Kallidin-Gq/β1/γ2
4.17	Consensus	bk2_on_gp	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/β1/γ2 7F6I-BK₂-Kallidin-Gq/β1/γ2
4.17	Consensus	bradykinin_on	Orthosteric Ligand	bk2_on
4.17	Consensus	bradykinin_on_gp	Orthosteric Ligand	bk2_on_gp
4.17	Consensus	gq_bradykinin	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/β1/γ2 7F6I-BK₂-Kallidin-Gq/β1/γ2

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F96	R:R:L99	4.87	No	No	4	7	1	2
R:R:F96	W:W:?2	9.36	No	No	4	0	1	0
R:R:N100	W:W:?2	14.08	No	No	8	0	1	0
R:R:F96	R:R:L95	1.22	No	No	4	6	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
66.67	Single	8W8R	AA-14	8W8R-GPR101-AA-14-chim(NtGi1-Gs)/β1/γ2
25.00	Single	8TLM	Anti-murine CCR8 antibody	8TLM-CCR8-Anti-murine CCR8 antibody
8.33	Single	8YIC	SAR247799	8YIC-S1P₁-SAR247799-Gi1/β1/γ2
8.33	Single	9IMA	Talquetamab	9IMA-GPRC5D-Talquetamab
7.14	Single	7XBD	Galanin	7XBD-GAL₂-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.14	Single	7XJL	Spexin	7XJL-GAL₂-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.67	Single	4PY0	2MeSATP	4PY0-P2Y₁₂-2MeSATP
6.67	Single	7WQ4	Galanin	7WQ4-GAL₂-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67	Single	7XJK	Galanin	7XJK-GAL₂-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.67	Single	7XXI	2MeSADP	7XXI-P2Y₁₂-2MeSADP-Gi2/β1/γ2
6.67	Consensus	galanin_on	Orthosteric Ligand	gal2_on gal1_on
6.67	Consensus	galanin_on_gp	Orthosteric Ligand	gal2_on_gp gal1_on_gp
6.67	Consensus	gi_p2y	Orthosteric Ligand	7XXI-P2Y₁₂-2MeSADP-Gi2/β1/γ2
6.67	Consensus	p2y12_on_gp	Orthosteric Ligand	7XXI-P2Y₁₂-2MeSADP-Gi2/β1/γ2
6.25	Single	8HN1	Toxin AdTx1	8HN1-Alpha1A-Toxin AdTx1
6.25	Single	8XWV	CXCL1	8XWV-CXCR2-CXCL1-Go/β1/γ2
6.25	Consensus	gal2_on	Orthosteric Ligand	7WQ4-GAL₂-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL₂-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.25	Consensus	gal2_on_gp	Orthosteric Ligand	7WQ4-GAL₂-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL₂-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.88	Single	5VBL	Apelin mimetic peptide agonist	5VBL-Apelin-Apelin mimetic peptide agonist
5.88	Consensus	kiss1_on	Orthosteric Ligand	8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
5.88	Consensus	kisspeptin_on	Orthosteric Ligand	kiss1_on
5.56	Single	7F4I	SHU9119	7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/β1/γ2
5.56	Single	8KIG	SHU9119	8KIG-MC₃-SHU9119-Ca
5.56	Single	8WKY	PG-934	8WKY-MC₄-PG-934
5.56	Single	8ZJD	Kisspeptin-10	8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
5.56	Consensus	gq_kisspeptin	Orthosteric Ligand	8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
5.56	Consensus	kiss1_on_gp	Orthosteric Ligand	8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
5.56	Consensus	kisspeptin_on_gp	Orthosteric Ligand	kiss1_on_gp
5.26	Single	8IOC	Gamma-MSH	8IOC-MC₃-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
5.26	Single	9EAI	Nanobody AT209	9EAI-AT₁-Losartan-Nanobody AT209
5.26	Consensus	mc5_on	Orthosteric Ligand	8INR-MC₅-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
5.00	Single	7F4D	Alpha-MSH	7F4D-MC₁-α-MSH-chim(NtGi1-Gs)/β1/γ2
5.00	Consensus	mc3_on	Orthosteric Ligand	8IOC-MC₃-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
5.00	Consensus	mc3_on_gp	Orthosteric Ligand	8IOC-MC₃-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
4.76	Single	7DW9	AVP	7DW9-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
4.76	Single	7F4H	Afamelanotide	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
4.76	Single	7XK8	Neuromedin-U-25	7XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
4.76	Consensus	gs_vasop-oxy	Orthosteric Ligand	7DW9-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
4.76	Consensus	mc5_on_gp	Orthosteric Ligand	8INR-MC₅-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
4.76	Consensus	v2_on	Orthosteric Ligand	7DW9-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
4.76	Consensus	v2_on_gp	Orthosteric Ligand	7DW9-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
4.76	Consensus	vasop-oxy_on	Orthosteric Ligand	v2_on
4.76	Consensus	vasop-oxy_on_gp	Orthosteric Ligand	v2_on_gp
4.55	Single	8IOD	PG-901	8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
4.55	Single	8XGO	TAK448	8XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
4.55	Consensus	mc1_on	Orthosteric Ligand	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC₁-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/β1/γ2
4.55	Consensus	mc1_on_gp	Orthosteric Ligand	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC₁-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/β1/γ2
4.17	Single	7F53	Alpha-MSH	7F53-MC₄-α-MSH-Gs/β1/γ2
4.17	Single	8ZJG	Chemerin	8ZJG-CML1-Chemerin-Gi1/β1/γ2
4.00	Single	8Y52	BA1	8Y52-BB₃-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00	Consensus	etb_on	Orthosteric Ligand	8IY5-ET_B-Endothelin-1-Gi1/β1/γ2 8HBD-ET_B-IRL1620-Gi1/β1/γ2
4.00	Consensus	gs_melanocortin	Orthosteric Ligand	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC₄-Afamelanotide-Gs/β1/γ2 7F4D-MC₁-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC₅-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC₄-α-MSH-Gs/β1/γ2 7F55-MC₄-Bremelanotide-Gs/β1/γ2 8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC₃-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC₄-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC₄-THIQ-Gs/β1/γ2
3.85	Single	8ZJE	TAK-448	8ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
3.70	Single	8HBD	IRL1620	8HBD-ET_B-IRL1620-Gi1/β1/γ2
3.70	Consensus	etb_on_gp	Orthosteric Ligand	8IY5-ET_B-Endothelin-1-Gi1/β1/γ2 8HBD-ET_B-IRL1620-Gi1/β1/γ2
3.70	Consensus	melanocortin_on	Orthosteric Ligand	mc1_on mc4_on mc2_on mc3_on mc5_on
3.70	Consensus	melanocortin_on_gp	Orthosteric Ligand	mc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
3.57	Single	6LRY	Sarafotoxin-B	6LRY-ET_B-Sarafotoxin-B
3.23	Consensus	mc2_on	Orthosteric Ligand	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
3.23	Consensus	mc2_on_gp	Orthosteric Ligand	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1

PDB Summary
PDB	8W8S
Class	A
SubFamily	Orphan
Type	Orphan
SubType	GPR101
Species	Homo Sapiens
Ligand	-
Other Ligand(s)	AA-14
Protein Partners	-
PDB Resolution	3.3
Date	2024-01-03
D.O.I.	10.1038/s41589-023-01456-6

Net Summary
I_min	1.62
Number of Linked Nodes	252
Number of Links	269
Number of Hubs	32
Number of Links mediated by Hubs	117
Number of Communities	11
Number of Nodes involved in Communities	40
Number of Links involved in Communities	45

Path Summary
Number Of Nodes in MetaPath	82
Number Of Links MetaPath	81
Number of Shortest Paths	32598
Length Of Smallest Path	3
Average Path Length	13.9211
Length of Longest Path	34
Minimum Path Strength	1.23
Average Path Strength	3.82664
Maximum Path Strength	20.345
Minimum Path Correlation	0.7
Average Path Correlation	0.927595
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.22581
Average % Of Corr. Nodes	54.169
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	36.7456
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • positive regulation of cell communication • regulation of cellular process • positive regulation of signal transduction • response to stimulus • signaling • positive regulation of biological process • regulation of signal transduction • intracellular signal transduction • cell communication • positive regulation of response to stimulus • regulation of intracellular signal transduction • intracellular signaling cassette • signal transduction • positive regulation of cellular process • regulation of biological process • regulation of signaling • positive regulation of MAPK cascade • biological regulation • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • cellular process • positive regulation of signaling • adenylate cyclase-activating adrenergic receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • adrenergic receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • protein-containing complex • receptor complex • cell periphery • cellular anatomical structure • plasma membrane • membrane
Gene Ontology	Cellular Component
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	U7D
PDB Residues	W:W:?1 W:W:?2
Environment Details	Open EMBL-EBI Page
Code	U7D
Name	1-(4-methylpyridin-2-yl)-3-[3-(trifluoromethyl)phenyl]thiourea
Synonyms	CHEMBL2134995
Identifier
Formula	C14 H12 F3 N3 S
Molecular Weight	311.325
SMILES
PubChem	848971
Formal Charge	0
Total Atoms	33
Total Chiral Atoms	0
Total Bonds	34
Total Aromatic Bonds	12


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q96P66
Sequence	>8W8S_Chain_R S L A H G I I R S T V L V I F L A A S F V G N I V L A L V L Q R K P Q L L Q V T N R F I F N L L V T D L L Q I S L V A P W V V A T S V P L F W P L N S H F C T A L V S L T H L F A F A S V N T I V V V S V D R Y L S I I H P L S Y P S K M T Q R R G Y L L L Y G T W I V A I L Q S T P P L Y G W G Q A A F D E R N A L C S M I W G A S P S Y T I L S V V S F I V I P L I V M I A C Y S V V F C A A R R Q H A L L Y N C K A A K V I F I I I F S Y V L S L G P Y C F L A V L A V W V D V E T Q V P Q W V I T I I I W L F F L Q C C I H P Y V Y G Y M H K T I K K E I Q D M L K K F F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8W8S	A	Orphan	Orphan	GPR101	Homo sapiens	-	AA-14	-	3.3	2024-01-03	10.1038/s41589-023-01456-6
	8W8R	A	Orphan	Orphan	GPR101	Homo sapiens	-	AA-14	chim(NtGi1-Gs)/β1/γ2	3.3	2024-01-03	10.1038/s41589-023-01456-6
	8W8Q	A	Orphan	Orphan	GPR101	Homo sapiens	-	-	Gs/β1/γ2	2.89	2024-01-03	10.1038/s41589-023-01456-6

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8W8S.zip

You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.

You can also read or download a guide explaining the meaning of all files and numerical data.