Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:P24 3.405417
2R:R:I39 3.395408
3R:R:E51 6.2825407
4R:R:F54 14.5175428
5R:R:W85 5.8725416
6R:R:P86 2.6725404
7R:R:L100 5.014517
8R:R:F101 8.3125407
9R:R:F102 8.25407
10R:R:R106 11.7875439
11R:R:I110 4.1625428
12R:R:R117 12.696529
13R:R:Y118 7.6875408
14R:R:Y127 7.262528
15R:R:D132 10.194528
16R:R:L153 5.48448
17R:R:S161 5.62415
18R:R:R162 9.4025414
19R:R:Q164 13.145417
20R:R:Y165 5.775403
21R:R:W169 9.86667615
22R:R:C170 5.83419
23R:R:F171 6.36716
24R:R:I172 4.875417
25R:R:W174 10.4267615
26R:R:H181 5.6925415
27R:R:Y184 6.3175448
28R:R:L195 5.93408
29R:R:I196 4.345407
30R:R:T199 4.695428
31R:R:I275 3.305407
32R:R:S278 3.445428
33R:R:R291 10.5925416
34R:R:N295 13.16416
35R:R:D311 8.7675416
36R:R:L312 6.9375416
37R:R:N321 7.1775439
38L:L:?1 9.124611310
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1L:L:?1 R:R:Y80 14.16911.93YesNo006
2R:R:I323 R:R:M27 12.07774.37NoNo088
3L:L:?1 R:R:M27 14.1691.92YesNo008
4R:R:C284 R:R:N321 15.85417.87NoYes099
5R:R:C284 R:R:I317 18.37743.27NoNo098
6R:R:I317 R:R:P287 19.62623.39NoNo089
7R:R:I286 R:R:P287 20.86655.08NoNo079
8R:R:I196 R:R:I286 22.09824.42YesNo077
9R:R:I196 R:R:L107 91.84845.71YesNo078
10R:R:L107 R:R:L195 91.95114.15NoYes088
11R:R:F191 R:R:L195 10013.4NoYes068
12R:R:F191 R:R:L104 90.18487.31NoNo668
13R:R:L104 R:R:Y188 93.058810.55NoNo087
14R:R:L100 R:R:Y188 92.46438.21YesNo077
15R:R:F171 R:R:L100 78.28674.87YesYes167
16R:R:F171 R:R:L99 24.08696.09YesNo068
17L:L:?1 R:R:L99 22.10254.69YesNo008
18R:R:F171 R:R:W169 37.65295.01YesYes165
19L:L:?1 R:R:W169 24.22387.73YesYes105
20R:R:N35 R:R:P326 12.31299.77NoNo099
21R:R:L62 R:R:N35 14.60538.24NoNo089
22R:R:L62 R:R:V58 21.55082.98NoNo088
23R:R:M113 R:R:V58 37.81543.04NoNo098
24R:R:I110 R:R:M113 54.22124.37YesNo089
25R:R:I110 R:R:T199 53.53693.04YesYes288
26R:R:L282 R:R:T199 89.71862.95NoYes068
27R:R:I196 R:R:L282 89.88115.71YesNo076
28R:R:L273 R:R:Y329 10.798911.72NoNo089
29R:R:V58 R:R:Y329 17.680311.36NoNo089
30R:R:E51 R:R:M270 12.82614.06YesNo079
31R:R:F54 R:R:M270 13.061311.2YesNo289
32R:R:F54 R:R:M113 34.00488.71YesNo089
33R:R:F54 R:R:L274 28.11566.09YesNo288
34R:R:L274 R:R:S278 25.35714.5NoYes288
35R:R:S278 R:R:T199 33.96633.2YesYes288
36R:R:R117 R:R:Y127 17.53915.14YesYes298
37R:R:F54 R:R:R117 44.504332.07YesYes289
38R:R:D132 R:R:R117 17.21849.53YesYes289
39R:R:E116 R:R:R117 10.38839.3NoYes299
40R:R:L61 R:R:T64 10.04622.95NoNo099
41R:R:T64 R:R:Y144 10.39268.74NoNo098
42R:R:F101 R:R:Y144 10.83747.22YesNo078
43R:R:F101 R:R:S105 17.2747.93YesNo078
44R:R:N147 R:R:S105 18.03955.96NoNo088
45R:R:N147 R:R:S108 18.93765.96NoNo087
46R:R:L195 R:R:S108 20.05393YesNo087
47R:R:C170 R:R:W85 17.40237.84YesYes196
48R:R:C170 R:R:S161 22.4193.44YesYes195
49R:R:S161 R:R:T96 30.77156.4YesNo157
50R:R:L100 R:R:T96 23.44972.95YesNo177
51R:R:F171 R:R:I172 11.0477.54YesYes167
52R:R:S114 R:R:T199 13.25389.59NoYes098
53R:R:C202 R:R:S114 11.96653.44NoNo079
54R:R:I275 R:R:N203 11.67995.66YesNo079
55R:R:V131 R:R:Y127 12.338.83NoYes278
56R:R:L135 R:R:V131 21.78171.49NoNo057
57R:R:L135 R:R:Y130 18.17218.21NoNo055
58R:R:H129 R:R:Y130 10.92723.27NoNo055
59R:R:D132 R:R:V131 13.04855.84YesNo287
60R:R:F150 R:R:M187 11.66718.71NoNo075
61R:R:M187 R:R:Y184 10.47393.59NoYes058
62R:R:F171 R:R:W174 27.66239.02YesYes165
63R:R:P166 R:R:T168 12.65938.74NoNo066
64R:R:P166 R:R:Y165 11.286512.52NoYes063
65R:R:V292 R:R:W174 12.21023.68NoYes075
66R:R:A189 R:R:V292 10.71343.39NoNo077
67R:R:T168 R:R:W169 12.74064.85NoYes165
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:V21 R:R:Y80 3.79 0 No No 6 6 2 1
R:R:I23 R:R:P24 3.39 1 No Yes 6 7 1 1
L:L:?1 R:R:I23 3.87 1 Yes No 0 6 0 1
R:R:P24 R:R:T76 3.5 1 Yes No 7 8 1 1
R:R:I77 R:R:P24 3.39 0 No Yes 6 7 2 1
L:L:?1 R:R:P24 3.34 1 Yes Yes 0 7 0 1
R:R:I323 R:R:M27 4.37 0 No No 8 8 2 1
R:R:L99 R:R:V72 2.98 0 No No 8 7 1 2
L:L:?1 R:R:T76 10 1 Yes No 0 8 0 1
L:L:?1 R:R:Y80 11.93 1 Yes No 0 6 0 1
R:R:F171 R:R:L99 6.09 1 Yes No 6 8 2 1
L:L:?1 R:R:L99 4.69 1 Yes No 0 8 0 1
R:R:Q164 R:R:W169 23 1 Yes Yes 7 5 2 1
R:R:F171 R:R:Q164 4.68 1 Yes Yes 6 7 2 2
R:R:P166 R:R:T168 8.74 0 No No 6 6 2 1
R:R:T168 R:R:W169 4.85 1 No Yes 6 5 1 1
L:L:?1 R:R:T168 3 1 Yes No 0 6 0 1
R:R:F171 R:R:W169 5.01 1 Yes Yes 6 5 2 1
R:R:L312 R:R:W169 5.69 1 Yes Yes 6 5 1 1
R:R:I315 R:R:W169 12.92 1 No Yes 6 5 1 1
L:L:?1 R:R:W169 7.73 1 Yes Yes 0 5 0 1
R:R:L312 R:R:N309 13.73 1 Yes No 6 2 1 2
R:R:L312 R:R:R316 3.64 1 Yes No 6 7 1 1
L:L:?1 R:R:L312 4.69 1 Yes Yes 0 6 0 1
L:L:?1 R:R:I315 11.62 1 Yes No 0 6 0 1
L:L:?1 R:R:R316 39.56 1 Yes No 0 7 0 1
L:L:?1 R:R:S319 13.24 1 Yes No 0 8 0 1
L:L:?1 R:R:V320 3.03 1 Yes No 0 5 0 1
R:R:P20 R:R:Y80 2.78 0 No No 5 6 2 1
L:L:?1 R:R:M27 1.92 1 Yes No 0 8 0 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
100.00Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
100.00Consensusep_offOrthosteric Ligandep4_off
62.50Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
56.25Single8GDBPGE28GDB-EP4-PGE2-Gs/&β;1/&γ;2
53.33Consensusprostanoid_offOrthosteric Ligandep_off tp_off dp_off
52.94Single6IIURamatroban6IIU-TP-Ramatroban
52.94Single8GCPPGE28GCP-EP4-PGE2-Gi1/&β;1/&γ;2
52.94Consensusep_onOrthosteric Ligandep4_on ep2_on ep3_on
52.94Consensusgi_prostanoidOrthosteric Ligand8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GDC-EP3-PGE2-Gi1/&β;1/&γ;2 8GCM-EP4-L902688-Gi1/&β;1/&γ;2
50.00Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
50.00Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2
50.00Single8GDAL9026888GDA-EP4-L902688-Gs/&β;1/&γ;2
50.00Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/&β;1/&γ;2
50.00Consensusep2_onOrthosteric Ligand7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
50.00Consensusep4_onOrthosteric Ligand7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2
50.00Consensusgs_prostanoidOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
46.67Single8GCML9026888GCM-EP4-L902688-Gi1/&β;1/&γ;2
46.67Single8K5CAcipimox8K5C-HCA2-Acipimox
45.00Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
44.44Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1
44.44Consensusprostanoid_onOrthosteric Ligandep_on fpa_on
43.75Single6IIVDaltroban6IIV-TP-Daltroban
43.75Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/&β;1/&γ;2
43.75Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
43.75Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
43.75Consensustp_offOrthosteric Ligand6IIV-TP-Daltroban 6IIU-TP-Ramatroban
42.86Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2
42.86Single8JILNiacin8JIL-HCA2-Niacin-Gi1/&β;1/&γ;2
42.86Single8K5BNiacin8K5B-HCA2-Niacin
42.11Single7CX2PGE27CX2-EP2-PGE2-Gs/&β;1/&γ;2
42.11Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
42.11Consensusgs_lipidOrthosteric Ligandgs_ffa gs_prostanoid
41.18Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
41.18Single7YXAONO-54306087YXA-S1P5-ONO-5430608
41.18Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2
41.18Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
41.18Consensusccr2_off_alloOther Ligand5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
40.00Single5ZKQABT-4915ZKQ-PAF-ABT-491
40.00Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
38.89Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2
38.89Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2
38.89Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
38.89Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/&β;1/&γ;2
37.50Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
37.50Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
37.50Single8JERAcipimox8JER-HCA2-Acipimox-Go/&β;1/&γ;2
37.50Single8JHNMMF8JHN-HCA2-MMF-Go/&β;1/&γ;2
37.50Single8JIMMMF8JIM-HCA2-MMF-Gi1/&β;1/&γ;2
37.50Single8K2WAMG4878K2W-CXCR3-AMG487
37.50Consensushca_onOrthosteric Ligandhca2_on hca3_on
37.50Consensushcar_onOrthosteric Ligandhca_on
36.36Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
36.36Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
35.29Single4YAYZD-71554YAY-AT1-ZD-7155
35.29Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
35.29Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
35.29Single7T2GMitragynine pseudoindoxyl7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
35.29Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
35.29Consensusgi_hcaOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
35.29Consensusgi_hcarOrthosteric Ligandgi_hca
35.29Consensushca2_onOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
35.29Consensushca3_onOrthosteric Ligand8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
35.29Consensushcar_offOrthosteric Ligandsuccinate_off
35.29Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
35.29Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
35.00Consensusfpa_onOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Single6GPXMK08126GPX-CCR2-MK0812
33.33Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
33.33Single7SK9CCX6627SK9-ACKR3-CCX662
33.33Single8GDCPGE28GDC-EP3-PGE2-Gi1/&β;1/&γ;2
33.33Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2
33.33Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
33.33Single8IJANiacin8IJA-HCA2-Niacin-Gi1/&β;1/&γ;2
33.33Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Single8IY9Niacin8IY9-HCA2-Niacin-Go/&β;1/&γ;2
33.33Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
33.33Consensusep3_onOrthosteric Ligand8GDC-EP3-PGE2-Gi1/&β;1/&γ;2
31.82Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
31.82Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
31.58Single7TUYGSK682753A7TUY-GPR183-GSK682753A
31.58Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
31.25Single5U09Taranabant5U09-CB1-Taranabant
31.25Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
31.25Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
31.25Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2
30.77Single7XKEBetahydroxyandrosterone7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
30.00Single5X33BIIL2605X33-BLT1-BIIL260
30.00Single7K15MKD0467K15-BLT1-MKD046-Na
30.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
30.00Consensusblt1_offOrthosteric Ligand7K15-BLT1-MKD046-Na
30.00Consensusblt_offOrthosteric Ligandblt1_off
30.00Consensusleuko_offOrthosteric Ligandblt_off cyslt_off
29.41Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
29.41Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
29.41Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
29.41Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
29.41Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
29.41Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
29.41Consensush3_on_alloOrthosteric Ligand7F61-H3-PF-03654746-Cholesterol
29.41Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
29.41Consensuss1p_offOrthosteric Ligands1p1_off
28.57Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
28.57Single7XK2MK68927XK2-HCA2-MK6892-Gi1/&β;1/&γ;2
28.57Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.57Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.57Single8WRZ8D08WRZ-CB1-8D0-Arrestin1
28.57Consensushca2_on_alloOrthosteric Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
28.00Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
28.00Single8J6IMK68928J6I-HCA2-MK6892-Gi1/&β;1/&γ;2
28.00Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
27.78Single2Y01Dobutamine2Y01-β1-Dobutamine
27.78Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
27.78Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
27.78Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
27.78Single5TGZAM65385TGZ-CB1-AM6538
27.78Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
27.78Single6GPSMK08126GPS-CCR2-MK0812
27.78Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2
27.78Single7V3ZPubMed 1048957V3Z-CB1-PubMed 104895
27.78Single7VKTLTB47VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
27.78Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/&β;1/&γ;2
27.78Single8K5DGSK2560738K5D-HCA2-GSK256073
27.78Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
27.78Consensusblt_onOrthosteric Ligandblt1_on
27.78Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
27.78Consensusleuko_onOrthosteric Ligandblt_on
27.27Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
27.27Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
27.27Single7XY6PubChem 117178317XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
27.27Single8XZFWN5618XZF-Apelin-WN561-Gi1/&β;1/&γ;2
27.27Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
27.27Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
27.27Consensuslpl_offOrthosteric Ligands1p_off lpa_off
27.27Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
26.92Single7KH0Acyclovir triphosphate7KH0-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
26.92Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
26.92Consensusbk1_onOrthosteric Ligand7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.92Consensusgs_bradykininOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.92Consensusgs_melanocortinOrthosteric Ligand7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2
26.67Single3OE6IT1t3OE6-CXCR4-IT1t
26.67Single6LI0GTPL98046LI0-GPR52-GTPL9804
26.67Single7F61Cholesterol7F61-H3-PF-03654746-Cholesterol
26.67Single8J6QBeta-hydroxybutyrate8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
26.67Consensush3_on_alloOther Ligand7F61-H3-PF-03654746-Cholesterol
26.32Single2Y00Dobutamine2Y00-β1-Dobutamine
26.32Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
26.32Single6D26Fevipiprant6D26-DP2-Fevipiprant
26.32Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
26.32Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
26.32Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
26.32Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
26.32Consensuscb2_onOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
26.09Single4XT1Fractalkine4XT1-US28-Fractalkine
26.09Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
26.09Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
26.09Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
25.93Single4XT3Fractalkine4XT3-US28-Fractalkine
25.93Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
25.00Single3OE9IT1t3OE9-CXCR4-IT1t
25.00Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
25.00Single5L7IVismodegib5L7I-SMO-Vismodegib
25.00Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
25.00Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
25.00Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
25.00Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
25.00Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
25.00Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/&β;1/&γ;2
25.00Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
25.00Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
25.00Single8X79MRE-2698X79-I2-MRE-269-Gs/&β;1/&γ;2
25.00Consensusangiotensin_offOrthosteric Ligandat1_off at2_off
25.00Consensuscck_onOrthosteric Ligandccka_on cckb_on
25.00Consensuscx3cr_onOrthosteric Ligandcx3cr1_on
24.14Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
24.14Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
24.00Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
24.00Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
24.00Consensuscx3cr1_onOrthosteric Ligand7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
23.81Single4N4WSANT-14N4W-SMO-SANT-1
23.81Single6A93Risperidone6A93-5-HT2A-Risperidone
23.81Single6H7N(S)-Xamoterol6H7N-β1-(S)-Xamoterol
23.81Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
23.81Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
23.81Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
23.81Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
23.81Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
23.81Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
23.81Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2
23.81Single8J6DEP1418J6D-C3aB-EP141-Go/&β;1/&γ;2
23.81Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/&β;1/&γ;2
23.81Consensusat2_offOrthosteric Ligand7JNI-AT2-Olodanrigan
23.81Consensusbeta1_onOrthosteric Ligand7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
23.81Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
23.81Consensuscannabinoid_onOrthosteric Ligandcb1_on cb2_on
23.81Consensuscb1_onOrthosteric Ligand8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
23.81Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
23.81Consensusdp_offOrthosteric Liganddp2_off
23.81Consensusgi_cannabinoidOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
23.81Consensusopioid_offOrthosteric Ligandkop_off mop_off nop_off dop_off
23.53Single3ODUIT1t3ODU-CXCR4-IT1t
23.53Single3PWHZM2413853PWH-A2A-ZM241385
23.53Single4S0VSuvorexant4S0V-OX2-Suvorexant
23.53Single5WS3EMPA5WS3-OX2-EMPA
23.53Single6AKXA4R6AKX-CCR5-A4R
23.53Single6AKYMaraviroc6AKY-CCR5-Maraviroc
23.53Single6TPJSuvorexant6TPJ-OX2-Suvorexant
23.53Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
23.53Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
23.53Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
23.53Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
23.53Single8EFOPZM218EFO-μ-PZM21-Gi1/&β;1/&γ;2
23.53Single8IHKAcifran8IHK-HCA3-Acifran
23.53Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
23.53Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
23.53Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
23.53Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
23.53Consensusgi_nucleotideOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
23.53Consensusm2_on_alloOther Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
23.08Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
23.08Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
23.08Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
23.08Single8IHFMK68928IHF-HCA2-MK6892-Gi1/&β;1/&γ;2
23.08Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
22.73Single6H7LDobutamine6H7L-β1-Dobutamine
22.73Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
22.73Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
22.73Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
22.73Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
22.73Single7XJISolabegron7XJI-β3-Solabegron-Gs/&β;1/&γ;2
22.73Single8GAGYVF8GAG-CB1-YVF-Gi1/&β;1/&γ;2
22.73Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
22.73Consensusadgrg2_onOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
22.73Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
22.73Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
22.73Consensusot_onOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
22.73Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
22.58Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
22.22Single2YDOAdenosine2YDO-A2A-Adenosine
22.22Single4MBSMaraviroc4MBS-CCR5-Maraviroc
22.22Single4ZJCSB-6740424ZJC-OX1-SB-674042
22.22Single6DS0Ly2660976DS0-5-HT2B-Ly266097
22.22Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
22.22Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
22.22Single6TP3Nemorexant6TP3-OX1-Nemorexant
22.22Single6TPGEMPA6TPG-OX2-EMPA
22.22Single6V9SGTPL114036V9S-OX1-GTPL11403
22.22Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
22.22Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
22.22Single6ZG9GSK10347026ZG9-M1-GSK1034702
22.22Single7AROLUF58337ARO-A2A-LUF5833-Na
22.22Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
22.22Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
22.22Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
22.22Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
22.22Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
22.22Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
22.22Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
22.22Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
22.22Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2
22.22Single8GURPubChem 1048958GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2
22.22Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
22.22Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/&β;1/&γ;2
22.22Consensusgs_tarOrthosteric Ligand8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
22.22Consensusm1_off_alloOther Ligand6WJC-M1-Atropine-Muscarinic toxin 7
22.22Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
22.22Consensusox1_offOrthosteric Ligand6TOT-OX1-Lemborexant 6TP4-OX1-ACT-462206 6TP6-OX1-Filorexant 6V9S-OX1-GTPL11403 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ7-OX1-SB-334867 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant
21.88Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
21.74Single4UG2CGS216804UG2-A2A-CGS21680
21.74Single5EE7MK08935EE7-Glucagon-MK0893
21.74Single5ZTYAM102575ZTY-CB2-AM10257
21.74Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.74Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
21.74Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
21.74Single8IYHMK68928IYH-HCA2-MK6892-Go/&β;1/&γ;2
21.74Single8X5YAstemizole8X5Y-H1-Astemizole
21.74Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2 8I95-C3aB-EP54-Go/&β;1/&γ;2
21.74Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
21.74Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
21.74Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
21.74Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
21.74Consensusgo_vasopressinOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
21.74Consensuslpl_onOrthosteric Ligands1p_on lpa_on
21.43Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
21.43Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
21.43Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
21.43Consensusgi_neuromedinOrthosteric Ligand7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
21.21Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
21.05Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
21.05Single5UENDU1725UEN-A1-DU172
21.05Single6TOTLemborexant6TOT-OX1-Lemborexant
21.05Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
21.05Single7BU7BI1671077BU7-β1-BI167107
21.05Single7CRHSKF839597CRH-D1-SKF83959-Gs/&β;1/&γ;2
21.05Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
21.05Single7UL4Alvimopan7UL4-μ-Alvimopan
21.05Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
21.05Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
21.05Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
21.05Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
21.05Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
21.05Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
21.05Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
21.05Consensusadenosine_onOrthosteric Liganda1_on a2_on
21.05Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
21.05Consensuscb1_on_alloOrthosteric Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
21.05Consensusnucleotide_onOrthosteric Ligandadenosine_on
21.05Consensustar_onOrthosteric Ligandta1_on
20.83Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
20.83Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
20.83Single7F8XNN90567F8X-CCKA-NN9056
20.83Single7QA8Peptide7QA8-STE2-Peptide
20.83Single7QA8Peptide7QA8-STE2-Peptide
20.83Single8GHVPubChem 1459649038GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
20.83Single8J6RMK68928J6R-HCA2-MK6892-Gi1/&β;1/&γ;2
20.83Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
20.83Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
20.83Consensusclass-d_offOrthosteric Ligandste2_off
20.83Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
20.83Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
20.83Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
20.83Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
20.83Consensusmop_offOrthosteric Ligand7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
20.83Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
20.83Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
20.69Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
20.69Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
20.69Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
20.00Single3QAKUK-4320973QAK-A2A-UK-432097
20.00Single4JKVTaladegib (LY2940680)4JKV-SMO-Taladegib (LY2940680)
20.00Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
20.00Single5C1MBU725C1M-μ-BU72
20.00Single5N2RPubChem 92460631; psb365N2R-A2A-PubChem 92460631; psb36-Na
20.00Single5WQCEMPA5WQC-OX2-EMPA
20.00Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
20.00Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
20.00Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
20.00Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
20.00Single6TP6Filorexant6TP6-OX1-Filorexant
20.00Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
20.00Single7C4SS1P7C4S-S1P3-S1P
20.00Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
20.00Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
20.00Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
20.00Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
20.00Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
20.00Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
20.00Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
20.00Single7SBFPZM217SBF-μ-PZM21-Gi1/&β;1/&γ;2
20.00Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Single7XKDBetahydroxyandrosterone7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
20.00Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
20.00Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
20.00Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Single8DZQmomSalB8DZQ-κ-momSalB-Go/&β;1/&γ;2
20.00Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
20.00Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
20.00Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
20.00Single8J19PubChem 1270454228J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
20.00Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
20.00Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
20.00Single8WC5Tetramethylammonium ion8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
20.00Consensusa1_on_alloOrthosteric Ligand7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
20.00Consensusadrenergic_offOrthosteric Ligandbeta_off alpha_off
20.00Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
20.00Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
20.00Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
20.00Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
20.00Consensusgo_opioidOrthosteric Ligand8DZQ-κ-momSalB-Go/&β;1/&γ;2
20.00Consensusgs_adrenergicOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJI-β3-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
20.00Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
20.00Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
20.00Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
19.35Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
19.35Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
19.35Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
19.35Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
19.35Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
19.35Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
19.35Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
19.23Single5WF5UK-4320975WF5-A2A-UK-432097
19.23Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
19.23Single6W25SHU91196W25-MC4-SHU9119-Ca
19.23Single7F4DAlpha-MSH7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
19.23Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
19.23Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
19.23Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
19.23Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
19.23Consensusangiotensin_onOrthosteric Ligandat1_on
19.23Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
19.23Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
19.23Consensusmc5_onOrthosteric Ligand8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
19.05Single2YDVNECA2YDV-A2A-NECA
19.05Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
19.05Single4DJHJDTic4DJH-κ-JDTic
19.05Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
19.05Single4UHRCGS216804UHR-A2A-CGS21680
19.05Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
19.05Single5G53NECA5G53-A2A-NECA-Gs
19.05Single5V56TC1145V56-SMO-TC114
19.05Single5V57TC1145V57-SMO-TC114
19.05Single5X93K-87945X93-ETB-K-8794
19.05Single5XR8AM8415XR8-CB1-AM841
19.05Single5XRAAM115425XRA-CB1-AM11542
19.05Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
19.05Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
19.05Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
19.05Single6TQ7SB-3348676TQ7-OX1-SB-334867
19.05Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2
19.05Single7EW7PubChem 40774607EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
19.05Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
19.05Single7FEEPubMed 1048957FEE-CB1-PubMed 104895-ZCZ011
19.05Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
19.05Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
19.05Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
19.05Single7WV9PubMed 1048957WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
19.05Single7XTQR3997XTQ-GPBA-R399-Gs/&β;1/&γ;2
19.05Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2
19.05Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/&β;1/&γ;2
19.05Single8DZPmomSalB8DZP-κ-momSalB-Gi1/&β;1/&γ;2
19.05Single8E0GBU728E0G-μ-BU72
19.05Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
19.05Single8G056-OAU8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
19.05Single8GUSHU-3088GUS-CB2-HU-308-Gi1/&β;1/&γ;2
19.05Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
19.05Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/&β;1/&γ;2
19.05Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
19.05Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
19.05Single8JXVClozapine8JXV-H4-Clozapine-Gi1/&β;1/&γ;2
19.05Single8JXWVUF68848JXW-H4-VUF6884-Gi1/&β;1/&γ;2
19.05Consensusa2_onOrthosteric Liganda2a_on a2b_on
19.05Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
19.05Consensusadenosine_offOrthosteric Liganda1_off a2_off
19.05Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
19.05Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
19.05Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
19.05Consensusdopamine_offOrthosteric Ligandd3_off d2_off d4_off
19.05Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A-NECA-Gs/&β;1/&γ;1 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
19.05Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2
19.05Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
19.05Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
19.05Consensusrelaxin_onOrthosteric Ligandrxfp4_on
19.05Consensuss1p2_onOrthosteric Ligand7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
19.05Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
18.75Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
18.75Single3OE8IT1t3OE8-CXCR4-IT1t
18.75Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
18.75Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/&β;1/&γ;2
18.75Single7MT8All-trans-retinal7MT8-Rhodopsin-All-trans-retinal-GRK1
18.75Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/&β;1/&γ;2
18.75Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
18.75Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.75Consensusglp_onOrthosteric Ligandglp1_on glp2_on
18.52Single6JODAngiotensin II6JOD-AT2-Angiotensin II
18.52Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
18.52Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
18.52Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
18.52Single7C61Ergotamine7C61-5-HT1B-Ergotamine
18.52Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
18.52Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
18.52Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
18.52Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
18.52Consensusclass-d_onOrthosteric Ligandste2_on
18.52Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
18.52Consensusgi_class-dOrthosteric Ligandgi_ste
18.52Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
18.52Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
18.18Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
18.18Single4LDEBI1671074LDE-β2-BI167107
18.18Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
18.18Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
18.18Single6CM4Risperidone6CM4-D2-Risperidone
18.18Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
18.18Single6KQIPubMed 1048956KQI-CB1-PubMed 104895-ORG27569
18.18Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
18.18Single6OS2TRV0266OS2-AT1-TRV026
18.18Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
18.18Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
18.18Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
18.18Single6ZG4HTL00099366ZG4-M1-HTL0009936
18.18Single7DFPSpiperone7DFP-D2-Spiperone
18.18Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/&β;1/&γ;2
18.18Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
18.18Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
18.18Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
18.18Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.18Single7YITNalfurafine7YIT-κ-Nalfurafine
18.18Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2
18.18Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2
18.18Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.18Single8IJDMK68928IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
18.18Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
18.18Single8JJ8Formoterol8JJ8-β2-Formoterol
18.18Single8JWYPubChem 1684517108JWY-A2A-PubChem 168451710
18.18Single8JWZAB9288JWZ-A2A-AB928-Na
18.18Single8WU1KCA8WU1-CB1-KCA-Arrestin1
18.18Consensuscb1_off_alloOrthosteric Ligand6KQI-CB1-PubMed 104895-ORG27569
18.18Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
18.18Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
18.18Consensusgs_bileacidOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
18.18Consensusgs_steroidOrthosteric Ligandgs_bileacid
18.18Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
18.18Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
18.18Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
17.95Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
17.86Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
17.86Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
17.86Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
17.86Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
17.86Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
17.86Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
17.86Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
17.86Consensusbombesin_onOrthosteric Ligandbb2_on bb1_on
17.86Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
17.86Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
17.86Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
17.65Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
17.65Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2
17.65Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
17.65Single7XKFBetahydroxyandrosterone7XKF-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
17.65Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
17.65Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.65Single8GEIEpinephrine8GEI-β2-Epinephrine-Gs/&β;1/&γ;2
17.65Single8GGCEpinephrine8GGC-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
17.65Single8GGEEpinephrine8GGE-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
17.65Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
17.65Single8HN8Histamine8HN8-H4-Histamine-Gi1/&β;1/&γ;2
17.65Single8ITFDMCHA8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
17.65Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
17.65Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
17.65Single8UNXEpinephrine8UNX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
17.65Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
17.65Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
17.65Consensusclass-t_onOrthosteric Ligandtaste2_on
17.65Consensusgs_class-tOrthosteric Ligandgs_taste
17.65Consensusgs_tasteOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
17.65Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
17.65Consensusox1_off_alloOrthosteric Ligand6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na 6TO7-OX1-Suvorexant-Na
17.65Consensustaste2_onOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
17.39Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
17.39Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
17.39Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
17.39Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
17.39Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
17.39Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
17.39Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
17.39Single6IBLArformoterol6IBL-β1-Arformoterol
17.39Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
17.39Single7EZCUKA7EZC-A2A-UKA
17.39Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
17.39Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
17.39Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
17.39Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/&β;1/&γ;2
17.39Single7XZ6APD6687XZ6-GPR119-APD668-Gs/&β;1/&γ;2
17.39Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
17.39Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
17.39Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
17.39Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
17.39Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/&β;1/&γ;2
17.39Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
17.39Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
17.39Consensusbeta1_off_alloOrthosteric Ligand4BVN-β1-Cyanopindolol-Na
17.39Consensusbileacid_onOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
17.39Consensusc5a1_off_ortoalloOrthosteric Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
17.39Consensusendothelin_offOrthosteric Ligandetb_off
17.39Consensusetb_offOrthosteric Ligand5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500 5X93-ETB-K-8794
17.39Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
17.39Consensussteroid_onOrthosteric Ligandbileacid_on
17.24Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
17.24Single6FJ3PTH6FJ3-PTH1-PTH
17.24Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/&β;1/&γ;2
17.24Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
17.24Single7SK3CXCL127SK3-ACKR3-CXCL12
17.24Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
17.24Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.24Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
17.24Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
17.24Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
17.24Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
17.24Consensusclass-d_onOrthosteric Ligandste2_on
17.24Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
17.24Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
17.24Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
17.24Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
17.24Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
17.24Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
16.67Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
16.67Single3NY9PubChem 9131033NY9-β2-PubChem 913103
16.67Single5DHHSB-6121115DHH-NOP-SB-612111
16.67Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
16.67Single5WF6UK-4320975WF6-A2A-UK-432097
16.67Single6B73PubChem 1319551386B73-κ-PubChem 131955138
16.67Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
16.67Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/&β;1/&γ;2
16.67Single6KUXRS-799486KUX-α2a-RS-79948
16.67Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
16.67Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
16.67Single6OYAAll-trans-retinal6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
16.67Single6TODEMPA6TOD-OX1-EMPA-Na
16.67Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
16.67Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
16.67Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
16.67Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2
16.67Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2
16.67Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
16.67Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
16.67Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
16.67Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
16.67Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
16.67Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
16.67Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
16.67Single7W0OElabela7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
16.67Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
16.67Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
16.67Single7XRRLemborexant7XRR-OX2-Lemborexant
16.67Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
16.67Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
16.67Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
16.67Single8GEAEpinephrine8GEA-β2-Epinephrine-Gs/&β;1/&γ;2
16.67Single8GECEpinephrine8GEC-β2-Epinephrine-Gs/&β;1/&γ;2
16.67Single8GEFEpinephrine8GEF-β2-Epinephrine-Gs/&β;1/&γ;2
16.67Single8GG9Epinephrine8GG9-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
16.67Single8GGAEpinephrine8GGA-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
16.67Single8GGVEpinephrine8GGV-β2-Epinephrine
16.67Single8GGWEpinephrine8GGW-β2-Epinephrine
16.67Single8GGXEpinephrine8GGX-β2-Epinephrine
16.67Single8GH0Epinephrine8GH0-β2-Epinephrine
16.67Single8GNGIstradefylline8GNG-A2A-Istradefylline
16.67Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/&β;1/&γ;2
16.67Single8HOCImetit8HOC-H4-Imetit-Gi1/&β;1/&γ;2
16.67Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
16.67Single8INRAlpha-MSH8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single8IW4Spermidine8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single8IWESpermidine8IWE-TAAR9-Spermidine
16.67Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single8UNWEpinephrine8UNW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
16.67Single8UO0Epinephrine8UO0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
16.67Single8UO3Epinephrine8UO3-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
16.67Single8W8RAA-148W8R-GPR101-AA-14-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Consensus5ht2_onOrthosteric Ligand5ht2a_on 5ht2c_on
16.67Consensusalpha1_onOrthosteric Ligandalpha1a_on
16.67Consensusalpha1a_onOrthosteric Ligand7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67Consensusalpha2_offOrthosteric Ligandalpha2a_off alpha2c_off
16.67Consensusalpha2a_offOrthosteric Ligand6KUX-α2a-RS-79948
16.67Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
16.67Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
16.67Consensusclass-d_offOrthosteric Ligandste2_off
16.67Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
16.67Consensusendothelin_onOrthosteric Ligandetb_on eta_on
16.67Consensusgi_class-dOrthosteric Ligandgi_ste
16.67Consensusgi_histamineOrthosteric Ligand8HN8-H4-Histamine-Gi1/&β;1/&γ;2 8HOC-H4-Imetit-Gi1/&β;1/&γ;2
16.67Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
16.67Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
16.67Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
16.67Consensusgs_histamineOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Consensusgt_class-aOrthosteric Ligandgt_opsin
16.67Consensusgt_opsinOrthosteric Ligandgt_sensory
16.67Consensusgt_sensoryOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
16.67Consensush4_onOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
16.67Consensusmglu_onOther Ligandmglu2_on mglu4_on
16.67Consensusorexin_offOrthosteric Ligandox2_off ox1_off
16.67Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
16.67Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
16.67Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
16.13Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
16.13Single6IGLIRL16206IGL-ETB-IRL1620
16.13Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
16.13Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
16.13Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
16.13Single8FEGPRD_0025178FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
16.13Consensuscrf1_onOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
16.13Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
16.13Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
16.13Consensusgs_endothelinOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.13Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
16.13Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
16.13Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
16.00Single4AMJ(S)-Carvedilol4AMJ-β1-(S)-Carvedilol
16.00Single4IARErgotamine4IAR-5-HT1B-Ergotamine
16.00Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
16.00Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
16.00Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
16.00Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
16.00Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.00Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
16.00Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
16.00Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
16.00Consensusnmur1_onOrthosteric Ligand7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.00Consensussst2_onOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
16.00Consensussst_onOrthosteric Ligandsst2_on sst4_on
15.79Single3REYPubChem 56973REY-A2A-PubChem 5697
15.79Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
15.79Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
15.79Single5IU4ZM2413855IU4-A2A-ZM241385-Na
15.79Single5IUBQ274563445IUB-A2A-Q27456344-Na
15.79Single5K2CZM2413855K2C-A2A-ZM241385-Na
15.79Single5NM4ZM2413855NM4-A2A-ZM241385-Na
15.79Single6AQFZM2413856AQF-A2A-ZM241385
15.79Single6IQLL7458706IQL-D4-L745870
15.79Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
15.79Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
15.79Single6PS4ICI 118-5516PS4-β2-ICI 118-551
15.79Single6VI4JDTic6VI4-κ-JDTic
15.79Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
15.79Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
15.79Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
15.79Single7F0TDopamine7F0T-D1-Dopamine-Gs/&β;1/&γ;2
15.79Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/&β;1/&γ;2
15.79Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.79Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
15.79Single7T32ZM2413857T32-A2A-ZM241385
15.79Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
15.79Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2
15.79Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
15.79Single7XJJGalanin7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
15.79Single7XOVSR1461317XOV-CCKA-SR146131-Gs/&β;1/&γ;2
15.79Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
15.79Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.79Single8GE1Epinephrine8GE1-β2-Epinephrine-Gs/&β;1/&γ;2
15.79Single8GE4Epinephrine8GE4-β2-Epinephrine-Gs/&β;1/&γ;2
15.79Single8GE6Epinephrine8GE6-β2-Epinephrine-Gs/&β;1/&γ;2
15.79Single8GE7Epinephrine8GE7-β2-Epinephrine-Gs/&β;1/&γ;2
15.79Single8GE8Epinephrine8GE8-β2-Epinephrine-Gs/&β;1/&γ;2
15.79Single8GE9Epinephrine8GE9-β2-Epinephrine-Gs/&β;1/&γ;2
15.79Single8GEGEpinephrine8GEG-β2-Epinephrine-Gs/&β;1/&γ;2
15.79Single8GFVEpinephrine8GFV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.79Single8GG3Epinephrine8GG3-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.79Single8GG4Epinephrine8GG4-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.79Single8GG8Epinephrine8GG8-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.79Single8GGIEpinephrine8GGI-β2-Epinephrine
15.79Single8GGQEpinephrine8GGQ-β2-Epinephrine
15.79Single8GGTEpinephrine8GGT-β2-Epinephrine
15.79Single8JLNT1AM8JLN-TA1-T1AM-Gs/&β;1/&γ;2
15.79Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
15.79Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.79Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.79Single8UHBRO52563908UHB-TA1-RO5256390-Gs/&β;1/&γ;2
15.79Single8UNQEpinephrine8UNQ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.79Single8UNREpinephrine8UNR-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.79Single8UNSEpinephrine8UNS-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.79Single8UNZEpinephrine8UNZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.79Single8UO2Epinephrine8UO2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.79Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.79Consensus5ht2a_onOrthosteric Ligand7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.79Consensusalpha2b_onOrthosteric Ligand6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
15.79Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
15.79Consensusd1_on_alloOrthosteric Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
15.79Consensusd3_onOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
15.79Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
15.79Consensusgo_galaninOrthosteric Ligand7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
15.79Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
15.79Consensusox2_offOrthosteric Ligand6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant
15.79Consensussensory_offOrthosteric Ligandopsin_off
15.62Single5GLHEndothelin-15GLH-ETB-Endothelin-1
15.62Single6IGKEndothelin-36IGK-ETB-Endothelin-3
15.62Consensusgs_crfOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
15.38Single6HLOAprepitant6HLO-NK1-Aprepitant
15.38Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
15.38Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
15.38Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
15.38Single7SK5CXCL127SK5-ACKR3-CXCL12
15.38Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
15.38Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
15.38Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
15.38Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
15.38Consensusalpha1_offOrthosteric Ligandalpha1a_off alpha1b_off
15.38Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
15.15Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
15.15Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
15.15Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
15.15Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
15.00Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
15.00Single2Y04Salbutamol2Y04-β1-Salbutamol
15.00Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
15.00Single3NY8ICI 118-5513NY8-β2-ICI 118-551
15.00Single3NYA(S)-Alprenolol3NYA-β2-(S)-Alprenolol
15.00Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
15.00Single4EIYZM2413854EIY-A2A-ZM241385-Na
15.00Single4EJ4Naltrindole4EJ4-δ-Naltrindole
15.00Single4GBR(S)-Carazolol4GBR-β2-(S)-Carazolol
15.00Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
15.00Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
15.00Single4QKXPubChem 762106284QKX-β2-PubChem 76210628
15.00Single4U16N-Methyl Scopolamine4U16-M3-N-Methyl Scopolamine
15.00Single5DHGPubChem 250014125DHG-NOP-PubChem 25001412
15.00Single5IU8Q274563475IU8-A2A-Q27456347-Na
15.00Single5JQH(S)-Carazolol5JQH-β2-(S)-Carazolol
15.00Single5OLGZM2413855OLG-A2A-ZM241385-Na
15.00Single5UIGJ3.651.884G5UIG-A2A-J3.651.884G
15.00Single5YC8N-Methyl Scopolamine5YC8-M2-N-Methyl Scopolamine
15.00Single5ZK8N-Methyl Scopolamine5ZK8-M2-N-Methyl Scopolamine
15.00Single5ZKCN-Methyl Scopolamine5ZKC-M2-N-Methyl Scopolamine
15.00Single6D27CAY104716D27-DP2-CAY10471
15.00Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
15.00Single6H7MSalbutamol6H7M-β1-Salbutamol
15.00Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
15.00Single6LPJZM2413856LPJ-A2A-ZM241385-Na
15.00Single6LPKZM2413856LPK-A2A-ZM241385-Na
15.00Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/&β;1/&γ;2
15.00Single6PRZ(S)-Alprenolol6PRZ-β2-(S)-Alprenolol
15.00Single6PS0(S)-Carazolol6PS0-β2-(S)-Carazolol
15.00Single6PS1Timolol6PS1-β2-Timolol
15.00Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
15.00Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.00Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
15.00Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
15.00Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
15.00Single7CFMP3957CFM-GPBA-P395-Gs/&β;1/&γ;2
15.00Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
15.00Single7LJCPubChem 867641037LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
15.00Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
15.00Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
15.00Single7PYRPSB-21157PYR-A2A-PSB-2115
15.00Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
15.00Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
15.00Single7SCGFH2107SCG-μ-FH210-Gi1/&β;1/&γ;2
15.00Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
15.00Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
15.00Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
15.00Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
15.00Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
15.00Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
15.00Single8CU6LJ-45178CU6-A2A-LJ-4517
15.00Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
15.00Single8GE3Epinephrine8GE3-β2-Epinephrine-Gs/&β;1/&γ;2
15.00Single8GEBEpinephrine8GEB-β2-Epinephrine-Gs/&β;1/&γ;2
15.00Single8GEEEpinephrine8GEE-β2-Epinephrine-Gs/&β;1/&γ;2
15.00Single8GEHEpinephrine8GEH-β2-Epinephrine-Gs/&β;1/&γ;2
15.00Single8GFWEpinephrine8GFW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.00Single8GFXEpinephrine8GFX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.00Single8GFYEpinephrine8GFY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.00Single8GFZEpinephrine8GFZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.00Single8GG0Epinephrine8GG0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.00Single8GG1Epinephrine8GG1-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.00Single8GG2Epinephrine8GG2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.00Single8GG6Epinephrine8GG6-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.00Single8GGJEpinephrine8GGJ-β2-Epinephrine
15.00Single8GGNEpinephrine8GGN-β2-Epinephrine
15.00Single8GGOEpinephrine8GGO-β2-Epinephrine
15.00Single8GGUEpinephrine8GGU-β2-Epinephrine
15.00Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
15.00Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2
15.00Single8J18(3R)-3-hydroxydodecanoic acid8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
15.00Single8JJOAlprenolol8JJO-β2-Alprenolol
15.00Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
15.00Single8JLZST19368JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
15.00Single8UNMEpinephrine8UNM-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.00Single8UNNEpinephrine8UNN-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.00Single8UNPEpinephrine8UNP-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.00Single8UO4Epinephrine8UO4-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
15.00Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
15.00Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
15.00Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
15.00Consensusa2_offOrthosteric Liganda2a_off
15.00Consensusa2a_offOrthosteric Ligand8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 5UIG-A2A-J3.651.884G 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-PubChem 168451710 5K2D-A2A-ZM241385
15.00Consensusadrenergic_onOrthosteric Ligandbeta_on alpha_on
15.00Consensusalpha2_onOrthosteric Ligandalpha2a_on alpha2b_on
15.00Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
15.00Consensusamine_onOrthosteric Ligandadrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
15.00Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
15.00Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
15.00Consensusdopamine_onOrthosteric Ligandd3_on d2_on d5_on d1_on
15.00Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
15.00Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
15.00Consensusgo_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
15.00Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
15.00Consensushistamine_onOrthosteric Ligandh1_on h4_on
15.00Consensusm2_on_alloOrthosteric Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
15.00Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
14.81Single3OE0CVX153OE0-CXCR4-CVX15
14.81Single6PT2KGCHM076PT2-δ-KGCHM07
14.81Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
14.81Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.81Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
14.81Single7XNACYN1548067XNA-SST2-CYN154806
14.81Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
14.81Consensusgi_chemerinOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
14.81Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
14.81Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
14.81Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
14.71Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
14.71Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
14.71Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
14.71Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
14.29Single2RH1(S)-Carazolol2RH1-β2-(S)-Carazolol
14.29Single2Y03Isoprenaline2Y03-β1-Isoprenaline
14.29Single2YCW(S)-Carazolol2YCW-β1-(S)-Carazolol
14.29Single5CGCHTL142425CGC-mGlu5-HTL14242
14.29Single5D6L(S)-Carazolol5D6L-β2-(S)-Carazolol
14.29Single5IUAQ274563485IUA-A2A-Q27456348-Na
14.29Single5N2SPSB365N2S-A1-PSB36
14.29Single5NM2ZM2413855NM2-A2A-ZM241385-Na
14.29Single5WIUNemonapride5WIU-D4-Nemonapride
14.29Single5WIVNemonapride5WIV-D4-Nemonapride-Na
14.29Single5X7D(S)-Carazolol5X7D-β2-(S)-Carazolol-PubChem 129318963
14.29Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
14.29Single5ZK3Quinuclidinyl benzilate hydrobromide5ZK3-M2-Quinuclidinyl benzilate hydrobromide
14.29Single6E67BI1671076E67-β2-BI167107-Gs (fused)
14.29Single6GDGNECA6GDG-A2A-NECA-Gs/&β;1/&γ;1
14.29Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
14.29Single6LPLZM2413856LPL-A2A-ZM241385-Na
14.29Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
14.29Single6PS3(S)-Carvedilol6PS3-β2-(S)-Carvedilol
14.29Single6PS6Timolol6PS6-β2-Timolol
14.29Single6S0QZM2413856S0Q-A2A-ZM241385
14.29Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
14.29Single6WQAZM2413856WQA-A2A-ZM241385-Na
14.29Single7BVQ(S)-Carazolol7BVQ-β1-(S)-Carazolol
14.29Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
14.29Single7CFNINT-7777CFN-GPBA-INT-777-Gs/&β;1/&γ;2
14.29Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
14.29Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
14.29Single7RM5ZM2413857RM5-A2A-ZM241385-Na
14.29Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.29Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2
14.29Single7SINNPS-21437SIN-CaS-NPS-2143
14.29Single7SINNPS-21437SIN-CaS-NPS-2143
14.29Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
14.29Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
14.29Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
14.29Single7WC6LSD7WC6-5-HT2A-LSD
14.29Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
14.29Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single7XKAEpinephrine7XKA-β2-Epinephrine
14.29Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
14.29Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
14.29Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
14.29Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.29Single8FYNZM2413858FYN-A2A-ZM241385-Na
14.29Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
14.29Single8UNYEpinephrine8UNY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.29Single8WCBCyclohexylammonium ion8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Single8WCCCyclohexylammonium ion8WCC-TA1-Cyclohexylammonium ion
14.29Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.29Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
14.29Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide 6DRX-5-HT2B-Lisuride
14.29Consensusa2a_onOrthosteric Ligand6GDG-A2A-NECA-Gs/&β;1/&γ;1
14.29Consensusalpha2a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
14.29Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
14.29Consensusamine_offOrthosteric Ligandadrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
14.29Consensusbeta2_offOrthosteric Ligand6PS2-β2-(S)-Alprenolol 6PS3-β2-(S)-Carvedilol 6PS5-β2-(S)-Propranolol 6PS6-β2-Timolol 2RH1-β2-(S)-Carazolol 6PS4-β2-ICI 118-551 3NY9-β2-PubChem 913103
14.29Consensusbeta2_onOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
14.29Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
14.29Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRR-D1-Rotigotine-Gs/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
14.29Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
14.29Consensusd4_offOrthosteric Ligand5WIU-D4-Nemonapride
14.29Consensusd4_off_alloOrthosteric Ligand5WIV-D4-Nemonapride-Na
14.29Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
14.29Consensusgi_adrenergicOrthosteric Ligand7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
14.29Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
14.29Consensusgi_somatostatinOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
14.29Consensusgo_amineOrthosteric Ligandgo_adrenergic go_muscarinic go_5ht
14.29Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
14.29Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
14.29Consensusgs_muscarinicOrthosteric Ligand8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.29Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
14.29Consensusm2_offOrthosteric Ligand5ZKB-M2-AF-DX 384 5ZKC-M2-N-Methyl Scopolamine 5ZK3-M2-Quinuclidinyl benzilate hydrobromide
14.29Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.29Consensusnmur2_onOrthosteric Ligand7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Consensusnmur_onOrthosteric Ligandnmur1_on nmur2_on
14.29Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
14.29Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
13.79Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
13.79Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.79Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
13.79Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
13.79Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
13.79Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.79Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.79Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
13.79Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.79Consensusgs_neuromedinOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.64Single3P0GBI1671073P0G-β2-BI167107
13.64Single3UONQuinuclidinyl benzilate hydrobromide3UON-M2-Quinuclidinyl benzilate hydrobromide
13.64Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
13.64Single4RWADIPP-NH24RWA-δ-DIPP-NH2
13.64Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
13.64Single4U15Tiotropium4U15-M3-Tiotropium
13.64Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
13.64Single5D5A(S)-Carazolol5D5A-β2-(S)-Carazolol
13.64Single5D5B(S)-Carazolol5D5B-β2-(S)-Carazolol
13.64Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
13.64Single6H7JIsoprenaline6H7J-β1-Isoprenaline
13.64Single6J21Aprepitant6J21-NK1-Aprepitant
13.64Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
13.64Single6OL9Tiotropium6OL9-M5-Tiotropium
13.64Single6OS1TRV0266OS1-AT1-TRV026
13.64Single7CKYPW04647CKY-D1-PW0464-Gs/&β;1/&γ;2
13.64Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
13.64Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2
13.64Single7JVPSKF839597JVP-D1-SKF83959-Gs/&β;1/&γ;2
13.64Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
13.64Single7PX4PSB-21137PX4-A2A-PSB-2113
13.64Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
13.64Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
13.64Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
13.64Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2
13.64Single7W41PD1762527W41-BB2-PD176252
13.64Single7W6PW967W6P-α2a-W96-Go/&β;1/&γ;2
13.64Single7W7EW587W7E-α2a-W58-Go/&β;1/&γ;2
13.64Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.64Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
13.64Single8EFLSR170188EFL-μ-SR17018-Gi1/&β;1/&γ;2
13.64Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
13.64Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.64Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
13.64Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/&β;1/&γ;2
13.64Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.64Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
13.64Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
13.64Consensus5ht5_offOrthosteric Ligand5ht5a_off
13.64Consensus5ht_offOrthosteric Ligand5ht2_off 5ht5_off 5ht1_off
13.64Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
13.64Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCZ-β1-Iodocyanopindolol
13.64Consensusbombesin_offOrthosteric Ligandbb2_off
13.64Consensusgi_amineOrthosteric Ligandgi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
13.64Consensusgi_dopamineOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
13.64Consensusgo_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
13.64Consensusgs_compl-peptideOrthosteric Ligand8I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.64Consensusgs_ffaOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2 8GDB-EP4-PGE2-Gs/&β;1/&γ;2
13.64Consensush1_offOrthosteric Ligand3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole 8X63-H1-Mepyramine 8X64-H1-Desloratadine
13.64Consensushistamine_offOrthosteric Ligandh1_off
13.64Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
13.64Consensuslpa_offOrthosteric Ligandlpa1_off
13.64Consensuslpa_onOrthosteric Ligandlpa1_on
13.64Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
13.64Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
13.64Consensusnpy_offOrthosteric Ligandnpy2_off npy1_off
13.64Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
13.33Single3PXOAll-trans-retinal3PXO-Rhodopsin-All-trans-retinal
13.33Single5DYSAll-trans-retinal5DYS-Rhodopsin-All-trans-retinal
13.33Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
13.33Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
13.33Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
13.33Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
13.33Single7D3SSecretin7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
13.33Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
13.33Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
13.33Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
13.33Single8GEJEpinephrine8GEJ-β2-Epinephrine-Gs/&β;1/&γ;2
13.33Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.33Single8PWNTheophylline8PWN-A2A-Theophylline
13.33Consensusbb1_onOrthosteric Ligand8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.33Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
13.33Consensusghrh_onOrthosteric Ligand7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
13.16Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
13.16Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
13.04Single3D4STimolol Maleate3D4S-β2-Timolol Maleate
13.04Single4AMIBucindolol4AMI-β1-Bucindolol
13.04Single5CXVTiotropium5CXV-M1-Tiotropium
13.04Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
13.04Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
13.04Single6MXTSalmeterol6MXT-β2-Salmeterol
13.04Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
13.04Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
13.04Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
13.04Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
13.04Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
13.04Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
13.04Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.04Single7WCNAR2314537WCN-GPR119-AR231453-Gs/&β;1/&γ;2
13.04Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.04Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.04Single7XMTJ-21567XMT-SST4-J-2156-Gi1/&β;1/&γ;2
13.04Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
13.04Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
13.04Single7Y66BM2137Y66-C5a1-BM213-Gi1/&β;1/&γ;2
13.04Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.04Single8I95EP548I95-C3aB-EP54-Go/&β;1/&γ;2
13.04Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
13.04Single8JJLOlodaterol8JJL-β2-Olodaterol
13.04Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
13.04Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg3_on
13.04Consensuschemokine_offOrthosteric Ligandcxcr_off
13.04Consensusclass-b2_onOrthosteric Ligandadgrg_on
13.04Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
13.04Consensuscxcr_offOrthosteric Ligandcxcr4_off
13.04Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
13.04Consensusgi_class-fOther Ligandgi_frizzled
13.04Consensusgi_frizzledOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
13.04Consensusgo_5htOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
13.04Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
13.04Consensuspeptide_offOrthosteric Ligandopioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
12.90Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
12.90Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
12.90Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
12.90Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
12.90Consensusetb_onOrthosteric Ligand8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
12.90Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
12.90Consensusgo_class-b1Orthosteric Ligandgo_crf
12.90Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
12.90Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
12.50Single2HPYAll-trans-retinal2HPY-Rhodopsin-All-trans-retinal
12.50Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
12.50Single5CGDHTL142425CGD-mGlu5-HTL14242
12.50Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
12.50Single6DDFDamgo6DDF-μ-Damgo-Gi1/&β;1/&γ;2
12.50Single6LMLGlucagon6LML-Glucagon-Glucagon
12.50Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Single6TQ9SB-4081246TQ9-OX1-SB-408124
12.50Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
12.50Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
12.50Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
12.50Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2
12.50Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
12.50Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
12.50Single7MTBAll-trans-retinal7MTB-Rhodopsin-All-trans-retinal-GRK1
12.50Single7UM4AS26747237UM4-5-HT5A-AS2674723
12.50Single7VGXNeuropeptide Y7VGX-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
12.50Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
12.50Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
12.50Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
12.50Single8A2OTheophylline8A2O-A2A-Theophylline-Na
12.50Single8E9YPubChem 4466038E9Y-M3-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.50Single8ID8TUG-8918ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
12.50Single8IWM2-Phenylethylamine8IWM-TAAR9-2-Phenylethylamine
12.50Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
12.50Single8IY6Endothelin-18IY6-ETB-Endothelin-1
12.50Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
12.50Consensus5ht5a_offOrthosteric Ligand7UM4-5-HT5A-AS2674723
12.50Consensuscckb_onOrthosteric Ligand7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
12.50Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
12.50Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.50Consensusgs_galaninOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.50Consensusgs_orexinOrthosteric Ligand7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
12.50Consensusorexin_onOrthosteric Ligandox2_on
12.50Consensussensory_onOrthosteric Ligandopsin_on
12.20Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
12.12Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
12.12Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
12.00Single6PT3DPI-2876PT3-δ-DPI-287
12.00Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.00Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
12.00Single7XN9L-054,5227XN9-SST2-L-054,522
12.00Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
12.00Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
12.00Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
12.00Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
12.00Consensusgs_adgrOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
12.00Consensusgs_class-b2Orthosteric Ligandgs_adgr
12.00Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.76Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
11.76Single3PQRAll-trans-retinal3PQR-Rhodopsin-All-trans-retinal-Gt(CT)
11.76Single3UZAGTPL92363UZA-A2A-GTPL9236
11.76Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
11.76Single6FUFAll-trans-retinal6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2
11.76Single7MT9All-trans-retinal7MT9-Rhodopsin-All-trans-retinal-GRK1
11.76Single7MTAAll-trans-retinal7MTA-Rhodopsin-All-trans-retinal-GRK1
11.76Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
11.76Single7WC5Psilocin7WC5-5-HT2A-Psilocin
11.76Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
11.76Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
11.76Single8GGREpinephrine8GGR-β2-Epinephrine
11.76Single8GGZEpinephrine8GGZ-β2-Epinephrine
11.76Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
11.76Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
11.76Single8IW72-Phenylethylamine8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
11.76Consensusopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
11.76Consensussmo_off_alloOrthosteric Ligand6D32-SMO-Cyclopamine-Cyclopamine
11.54Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
11.54Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
11.54Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
11.54Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
11.54Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.54Single8G59TUG-8918G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
11.43Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
11.43Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
11.43Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
11.11Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
11.11Single2G87All-trans-retinal2G87-Rhodopsin-All-trans-retinal
11.11Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
11.11Single3PBLEticlopride3PBL-D3-Eticlopride
11.11Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
11.11Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
11.11Single4O9RCyclopamine4O9R-SMO-Cyclopamine
11.11Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
11.11Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
11.11Single6QNOAll-trans-retinal6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
11.11Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
11.11Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
11.11Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
11.11Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
11.11Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
11.11Single7LD3PubChem 252636037LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
11.11Single7SRQLSD7SRQ-5-HT2B-LSD
11.11Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
11.11Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
11.11Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/&β;1/&γ;2
11.11Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2
11.11Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
11.11Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.11Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.11Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
11.11Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
11.11Single8GGSEpinephrine8GGS-β2-Epinephrine
11.11Single8GGYEpinephrine8GGY-β2-Epinephrine
11.11Single8GH1Epinephrine8GH1-β2-Epinephrine
11.11Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
11.11Single8UNVEpinephrine8UNV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
11.11Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
11.11Consensusa1_on_alloOther Ligand7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
11.11Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
11.11Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
11.11Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
11.11Consensusm4_on_alloOther Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
11.11Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
11.11Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
11.11Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
11.11Consensussmo_on_alloOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
11.11Consensussst_offOrthosteric Ligandsst2_off
10.81Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
10.81Consensuspth_onOrthosteric Ligandpth1_on pth2_on
10.71Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
10.71Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
10.71Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;2
10.71Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
10.71Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.71Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
10.53Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
10.53Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
10.53Single2X72All-trans-retinal2X72-Rhodopsin-All-trans-retinal-Gt(CT)
10.53Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
10.53Single3VG9ZM2413853VG9-A2A-ZM241385-Antibody
10.53Single3VGAZM2413853VGA-A2A-ZM241385-Antibody
10.53Single4BWBNeurotensin4BWB-NTS1-Neurotensin
10.53Single4QINSAG1.54QIN-SMO-SAG1.5
10.53Single5K2DZM2413855K2D-A2A-ZM241385
10.53Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
10.53Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
10.53Single6JZHZM2413856JZH-A2A-ZM241385-Na
10.53Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
10.53Single6OBA(S)-Alprenolol6OBA-β2-(S)-Alprenolol-GTPL11074
10.53Single6PS7ZM2413856PS7-A2A-ZM241385-Na
10.53Single7BR3Elagolix7BR3-GnRH1-Elagolix
10.53Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
10.53Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
10.53Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/&β;1/&γ;2
10.53Single7F8ULintitript7F8U-CCKA-Lintitript
10.53Single7F8YDevazepide7F8Y-CCKA-Devazepide
10.53Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
10.53Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;1
10.53Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
10.53Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
10.53Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
10.53Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
10.53Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
10.53Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.53Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
10.53Single7TUZ7alpha,25-dihydroxycholesterol7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
10.53Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
10.53Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
10.53Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
10.53Single8A6CAll-trans-retinal8A6C-Rhodopsin-All-trans-retinal
10.53Single8A6DAll-trans-retinal8A6D-Rhodopsin-All-trans-retinal
10.53Single8A6EAll-trans-retinal8A6E-Rhodopsin-All-trans-retinal
10.53Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
10.53Single8DWHCompound-168DWH-MRGPRX1-Compound-16-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.53Single8FN0Neurotensin/neuromedin N8FN0-NTS1-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
10.53Single8GEDEpinephrine8GED-β2-Epinephrine-Gs/&β;1/&γ;2
10.53Single8GG7Epinephrine8GG7-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
10.53Single8GGFEpinephrine8GGF-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
10.53Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
10.53Single8UNLEpinephrine8UNL-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
10.53Single8UNOEpinephrine8UNO-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
10.53Single8UNTEpinephrine8UNT-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
10.53Single8UNUEpinephrine8UNU-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
10.53Single8UO1Epinephrine8UO1-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
10.53Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
10.53Consensusa2a_off_alloOrthosteric Ligand6ZDR-A2A-HMS1413f12-Na 6GT3-A2A-Imaradenant-Na 8CU7-A2A-LJ-4517-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PubChem 92460631; psb36-Na 5MZJ-A2A-Theophylline-Na 5OLO-A2A-Tozadenant-Na 5OLH-A2A-Vipadenant-Na 5NM4-A2A-ZM241385-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5MZP-A2A-Caffeine-Na 8CIC-A2A-Etrumadenant-Na
10.53Consensusbeta2_off_alloOrthosteric Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
10.53Consensusclass-f_offOrthosteric Ligandsmo_off
10.53Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
10.53Consensusmelatonin_onOrthosteric Ligandmt1_on mt2_on
10.53Consensusopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
10.34Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
10.34Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
10.34Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.34Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
10.34Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
10.26Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
10.00Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
10.00Single4DKLBeta-funaltrexamine4DKL-μ-Beta-funaltrexamine
10.00Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
10.00Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
10.00Single5IU7Q274563465IU7-A2A-Q27456346-Na
10.00Single5JTBZM2413855JTB-A2A-ZM241385
10.00Single5K2BZM2413855K2B-A2A-ZM241385-Na
10.00Single5NLXZM2413855NLX-A2A-ZM241385-Na
10.00Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
10.00Single6MH8ZM2413856MH8-A2A-ZM241385
10.00Single6PS5(S)-Propranolol6PS5-β2-(S)-Propranolol
10.00Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
10.00Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
10.00Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
10.00Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
10.00Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
10.00Single6ZDVPubChem 9840736ZDV-A2A-PubChem 984073-Na
10.00Single7BB6Acyclovir triphosphate7BB6-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
10.00Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
10.00Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/&β;1/&γ;2
10.00Single7CMVPD1289077CMV-D3-PD128907-Gi1/&β;1/&γ;2
10.00Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
10.00Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2
10.00Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
10.00Single7JOZVFP7JOZ-D1-VFP-Gs/&β;1/&γ;2
10.00Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.00Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
10.00Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
10.00Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
10.00Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
10.00Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
10.00Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.00Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
10.00Single8GDZEpinephrine8GDZ-β2-Epinephrine-Gs/&β;1/&γ;2
10.00Single8GG5Epinephrine8GG5-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
10.00Single8GGKEpinephrine8GGK-β2-Epinephrine
10.00Single8GGMEpinephrine8GGM-β2-Epinephrine
10.00Single8GGPEpinephrine8GGP-β2-Epinephrine
10.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
10.00Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
10.00Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6WH4-5-HT2A-Methiothepin 7VOE-5-HT2A-Aripiprazole 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 6A93-5-HT2A-Risperidone
10.00Consensus5ht5_onOrthosteric Ligand5ht5a_on
10.00Consensus5ht5a_onOrthosteric Ligand7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
10.00Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
10.00Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
10.00Consensuscxcr_onOrthosteric Ligandcxcr1_on cxcr2_on
10.00Consensusdop_off_alloOrthosteric Ligand4N6H-δ-Naltrindole-Na
10.00Consensusgi_class-fOrthosteric Ligandgi_frizzled
10.00Consensusgi_frizzledOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
10.00Consensusgi_melatoninOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
10.00Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
10.00Consensusgnrh_offOrthosteric Ligandgnrh1_off
10.00Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.00Consensusm1_off_alloOrthosteric Ligand6WJC-M1-Atropine-Muscarinic toxin 7
9.76Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
9.68Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
9.68Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
9.52Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
9.52Single2Y02Carmoterol2Y02-β1-Carmoterol
9.52Single3EMLZM2413853EML-A2A-ZM241385
9.52Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
9.52Single4DAJTiotropium4DAJ-M3-Tiotropium
9.52Single4MQSIperoxo4MQS-M2-Iperoxo
9.52Single4U14Tiotropium4U14-M3-Tiotropium
9.52Single4X1HNonyl Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
9.52Single5DSGTiotropium5DSG-M4-Tiotropium
9.52Single5K2AZM2413855K2A-A2A-ZM241385-Na
9.52Single5T04Neurotensin5T04-NTS1-Neurotensin
9.52Single5VRAZM2413855VRA-A2A-ZM241385-Na
9.52Single6DRXLisuride6DRX-5-HT2B-Lisuride
9.52Single6PS2(S)-Alprenolol6PS2-β2-(S)-Alprenolol
9.52Single6S0LZM2413856S0L-A2A-ZM241385
9.52Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
9.52Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
9.52Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
9.52Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
9.52Single7F83PF-051904577F83-Ghrelin-PF-05190457
9.52Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
9.52Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/&β;1/&γ;2
9.52Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
9.52Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
9.52Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
9.52Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
9.52Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/&β;1/&γ;2
9.52Single7WC7Lisuride7WC7-5-HT2A-Lisuride
9.52Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
9.52Single8EFQDamgo8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
9.52Single8GGBEpinephrine8GGB-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
9.52Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
9.52Single8X63Mepyramine8X63-H1-Mepyramine
9.52Single8X64Desloratadine8X64-H1-Desloratadine
9.52Consensus5ht1a_onOrthosteric Ligand8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
9.52Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
9.52Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
9.52Consensuscck_offOrthosteric Ligandccka_off
9.52Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
9.52Consensusgi_5htOrthosteric Ligand7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
9.52Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
9.52Consensusm4_on_alloOrthosteric Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
9.52Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
9.52Consensussmo_offOrthosteric Ligand5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
9.38Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
9.38Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
9.38Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
9.09Single5TVNLSD5TVN-5-HT2B-LSD
9.09Single5XPRBosentan5XPR-ETB-Bosentan
9.09Single6DDEDamgo6DDE-μ-Damgo-Gi1/&β;1/&γ;2
9.09Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
9.09Single6LUQHaloperidol6LUQ-D2-Haloperidol
9.09Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
9.09Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
9.09Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
9.09Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
9.09Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
9.09Single7CKXA776367CKX-D1-A77636-Gs/&β;1/&γ;2
9.09Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2
9.09Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
9.09Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
9.09Single8EA0Iperoxo8EA0-M3-Iperoxo
9.09Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
9.09Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
9.09Single8GNEKW-63568GNE-A2A-KW-6356-Na
9.09Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
9.09Single8ID9Eicosapentaenoic acid8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
9.09Single8JPCNeurotensin 8-138JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
9.09Single8QOTNanobody E8QOT-μ-Nanobody E
9.09Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
9.09Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
8.82Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
8.82Single7TYIAmylin7TYI-CT-Amylin-Gs/&β;1/&γ;2
8.82Single7TYLAmylin7TYL-CT-Amylin-Gs/&β;1/&γ;2
8.82Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
8.70Single3SN6BI1671073SN6-β2-BI167107-Gs/&β;1/&γ;2
8.70Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
8.70Single4BV0Neurotensin4BV0-NTS1-Neurotensin
8.70Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
8.70Single5V54Methiothepin5V54-5-HT1B-Methiothepin
8.70Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
8.70Single6NI3BI1671076NI3-β2-BI167107-Gs/&β;1/&γ;2
8.70Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
8.70Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
8.70Single6WGTLSD6WGT-5-HT2A-LSD
8.70Single7B6WCyclazosin7B6W-α1b-Cyclazosin
8.70Single7EPENAM5637EPE-mGlu-NAM563
8.70Single7F1TMIP-1a7F1T-CCR5-MIP-1a
8.70Single7JV5SKF812977JV5-D1-SKF81297-Gs/&β;1/&γ;2
8.70Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1
8.70Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/&β;1/&γ;1
8.70Single7P2L4YI7P2L-mGlu5-4YI
8.70Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
8.70Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.70Single7XOWGastrin7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
8.70Single7XOXCholecystokinin-87XOX-CCKB-Cholecystokinin-8-Gq/&β;1/&γ;2
8.70Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.70Single8FMZNeurotensin/neuromedin N8FMZ-NTS1-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.70Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2
8.70Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
8.70Single8JD0J9R8JD0-mGlu2; mGlu3-Glutamate-J9R
8.70Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
8.70Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
8.70Consensus5ht1_offOrthosteric Ligand5ht1b_off
8.70Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
8.70Consensus5ht1b_onOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
8.70Consensusalpha1b_offOrthosteric Ligand7B6W-α1b-Cyclazosin
8.70Consensuschemerin_onOrthosteric Ligandcml1_on
8.70Consensuscml1_onOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
8.70Consensuscyslt1_off_ortoalloOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
8.70Consensusffa4_onOrthosteric Ligand8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
8.70Consensusgi_ffaOrthosteric Ligand8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
8.70Consensusgi_muscarinicOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
8.70Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl Scopolamine 5ZHP-M3-PubChem 134828589
8.70Consensusnts1_on_alloOrthosteric Ligand8JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
8.70Consensussst4_onOrthosteric Ligand7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
8.57Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
8.33Single4GRVNeurotensin 8-134GRV-NTS1-Neurotensin 8-13
8.33Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
8.33Single4XEENeurotensin4XEE-NTS1-Neurotensin
8.33Single4XESNeurotensin4XES-NTS1-Neurotensin
8.33Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
8.33Single6HLPNetupitant6HLP-NK1-Netupitant
8.33Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/&β;1/&γ;2
8.33Single6YVRNTS8-136YVR-NTS1-NTS8-13
8.33Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.33Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
8.33Single7Y24Octreotide7Y24-SST2-Octreotide-Go/&β;1/&γ;2
8.33Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.33Single8JPBNeurotensin 8-138JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
8.33Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
8.33Single8W8SAA-148W8S-GPR101-AA-14
8.33Consensusgpr119_onOrthosteric Ligand7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
8.33Consensusgs_trhOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
8.33Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
8.33Consensusnts1_onOrthosteric Ligand6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
8.33Consensusnts_onOrthosteric Ligandnts1_on
8.33Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
8.11Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
8.00Single4BUONeurotensin4BUO-NTS1-Neurotensin
8.00Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
8.00Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
8.00Single6K1QIRL25006K1Q-ETB-IRL2500
8.00Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
8.00Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
8.00Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.00Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
8.00Consensusgi_neurotensinOrthosteric Ligand7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
8.00Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.89Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
7.89Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
7.69Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
7.69Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
7.69Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.69Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
7.69Consensusgs_bombesinOrthosteric Ligand8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.69Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.41Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
7.41Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
7.41Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
7.41Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
7.41Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
7.41Consensusfpr-alx_onOrthosteric Ligandfpr1-alx_on fpr2-alx_on
7.41Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
7.32Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
7.14Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
7.14Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.14Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
6.90Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1
6.90Consensusgi_formylpeptideOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
6.90Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.90Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
6.82Single8F0JPramlintide analogue san458F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2
6.67Single4A4MAll-trans-retinal4A4M-Rhodopsin-All-trans-retinal-Gt(CT)
6.67Single5EN0All-trans-retinal5EN0-Rhodopsin-All-trans-retinal-Gt(CT)
6.67Single5MZPCaffeine5MZP-A2A-Caffeine-Na
6.67Single6W25Ca6W25-MC4-SHU9119-Ca
6.67Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
6.67Consensusccr8_offOrthosteric Ligand8TLM-CCR8-Anti-murine CCR8 antibody
6.45Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
6.45Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
6.25Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
6.25Single7WC4Serotonin7WC4-5-HT2A-Serotonin
6.25Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
6.25Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/&β;1/&γ;2
6.25Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
6.25Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
6.25Consensusgabab_offOther Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
6.06Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
5.88Single3RFMCaffeine3RFM-A2A-Caffeine
5.88Single6OY9All-trans-retinal6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
5.88Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
5.88Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
5.88Single7VDMSubstance P7VDM-MRGPRX2-Substance P-Gi1/&β;1/&γ;2
5.88Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/&β;1/&γ;2
5.88Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/&β;1/&γ;2
5.88Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
5.56Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
5.56Single4XNWMRS25004XNW-P2Y1-MRS2500
5.56Single5WKTOctyl Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
5.56Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
5.56Single6ME5Agomelatine6ME5-MT1-Agomelatine
5.56Single6ME9Ramelteon6ME9-MT2-Ramelteon
5.56Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
5.56Single7S8O(R)-Zinc-35737S8O-MRGPRX2-(R)-Zinc-3573-Gi1/&β;1/&γ;2
5.56Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.56Single8F76-8F76-OR51E2-Gs/&β;1/&γ;2
5.56Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
5.56Single8POKHistamine8POK-H2-Histamine-Gs/&β;1/&γ;2
5.56Consensusadgrg3_onOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
5.56Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
5.41Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
5.26Single3AYMAll-trans-retinal3AYM-Rhodopsin-All-trans-retinal
5.26Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
5.26Single6HLLCP999946HLL-NK1-CP99994
5.26Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
5.26Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
5.26Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
5.26Single6TP4ACT-4622066TP4-OX1-ACT-462206
5.26Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
5.26Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
5.26Single7S8N(R)-Zinc-35737S8N-MRGPRX2-(R)-Zinc-3573-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.26Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
5.26Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
5.26Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
5.26Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2
5.26Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
5.26Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
5.26Single8EF6Morphine8EF6-μ-Morphine-Gi1/&β;1/&γ;2
5.26Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
5.26Single8X2K5YM8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
5.26Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
5.26Consensus5ht4_onOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
5.26Consensusgo_adhesionOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
5.26Consensusgo_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
5.26Consensusgo_class-b2Orthosteric Ligandgo_adhesion
5.26Consensusgo_proteinOrthosteric Ligandgo_chemokine
5.26Consensusmt1_onOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
5.26Consensusmt2_onOrthosteric Ligand7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
5.00Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
5.00Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
5.00Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
5.00Single6ME2Ramelteon6ME2-MT1-Ramelteon
5.00Single6NWEOctyl Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
5.00Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
5.00Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
5.00Single6WWZCCL206WWZ-CCR6-CCL20-Go/&β;1/&γ;2
5.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
5.00Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
5.00Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
5.00Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2
5.00Single8F2APramlintide analogue san3858F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
5.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
5.00Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.00Single8U8FPML8U8F-GPR3-PML-Gs/&β;1/&γ;2
5.00Consensus5ht2c_onOrthosteric Ligand8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.00Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
5.00Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
5.00Consensusgs_5htOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.00Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
5.00Consensussmo_on_alloOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
4.76Single3RZECidoxepin3RZE-H1-Cidoxepin
4.76Single5TE3Octyl Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
4.76Single5UVIZM2413855UVI-A2A-ZM241385
4.76Single6A94Zotepine6A94-5-HT2A-Zotepine
4.76Single6FFIMMPEP6FFI-mGlu5-MMPEP
4.76Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
4.76Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
4.76Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
4.76Single6TPKRetosiban6TPK-OT-Retosiban
4.76Single6TPNHTL66416TPN-OX2-HTL6641
4.76Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
4.76Single7VODCariprazine7VOD-5-HT2A-Cariprazine
4.76Single7VV6C48/807VV6-MRGPRX2-C48/80
4.76Single7VVOPTH7VVO-PTH1-PTH-Gs/&β;1/&γ;2
4.76Single8GGLEpinephrine8GGL-β2-Epinephrine
4.76Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76Single8HQN9(S)-HODE8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
4.76Single8JD6N-(3-chlorophenyl)pyridine-2-carboxamide8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
4.76Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2
4.76Single8K4NVF08K4N-GPR34-VF0-Gi1/&β;1/&γ;2
4.76Consensusffa2_onOrthosteric Ligand8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
4.76Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
4.76Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
4.76Consensusvasopressin-ot_offOrthosteric Ligandot_off
4.65Single8F2BPramlintide analogue san458F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
4.55Single6FFHFenobam6FFH-mGlu5-Fenobam
4.55Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
4.55Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
4.55Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
4.55Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
4.55Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
4.55Single7RBTPubChem 1631837747RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
4.55Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
4.55Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
4.55Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
4.55Single8EJCTAK-8758EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
4.55Single8EJKTAK-8758EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
4.55Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
4.55Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
4.55Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
4.55Consensusffa_onOrthosteric Ligandffa4_on ffa1_on ffa2_on ffa3_on
4.55Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
4.55Consensustachykinin_offOrthosteric Ligandnk1_off
4.35Single4PHUFasiglifam4PHU-FFA1 (GPR40)-Fasiglifam
4.35Single4WW3All-trans-retinal4WW3-Rhodopsin-All-trans-retinal
4.35Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
4.35Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
4.35Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
4.35Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
4.35Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.35Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.35Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
4.35Consensusgs_sstOrthosteric Ligand7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.17Single5TZR-5TZR-FFA1 (GPR40)-MK8666
4.17Single6E59L-7607356E59-NK1-L-760735
4.17Single6J20Aprepitant6J20-NK1-Aprepitant
4.17Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
4.17Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
4.17Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
4.17Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
4.17Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
4.17Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
4.17Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
4.17Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
4.17Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
4.17Consensusmglu2_onOther Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
4.17Consensusnk1_offOrthosteric Ligand6J20-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
4.17Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
4.00Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
4.00Single4PY02MeSATP4PY0-P2Y12-2MeSATP
4.00Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
4.00Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
4.00Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
4.00Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
4.00Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
4.00Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.00Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
4.00Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.00Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
4.00Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
4.00Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
3.85Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
3.85Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
3.85Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
3.85Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
3.85Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
3.85Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
3.85Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.85Consensuscyslt2_offOrthosteric Ligand6RZ6-CysLT2-ONO-2570366 6RZ9-CysLT2-ONO-2770372 6RZ8-CysLT2-ONO-2080365
3.85Consensuscyslt_offOrthosteric Ligandcyslt2_off
3.85Consensusffa4_on_alloOrthosteric Ligand8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.70Single6KNMJN241-96KNM-Apelin-JN241-9
3.70Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
3.70Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
3.70Single8SAI1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
3.70Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
3.70Consensusfpr2-alx_onOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
3.57Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
3.57Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
3.45Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.33Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
2.78Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
2.78Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/&β;1/&γ;2; RAMP2
2.63Single8F0KPramlintide analogue san3858F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3

PDB Summary
PDB 5YWY
Class A
SubFamily Lipid
Type Prostanoid
SubType EP4
Species Homo sapiens
Ligand ONO-AE3-208
Other Ligand(s) -
Protein Partners -
PDB Resolution 3.2
Date 2018-12-05
D.O.I. 10.1038/s41589-018-0131-3
Net Summary
Imin 2.95
Number of Linked Nodes 251
Number of Links 285
Number of Hubs 38
Number of Links mediated by Hubs 140
Number of Communities 6
Number of Nodes involved in Communities 57
Number of Links involved in Communities 82
Path Summary
Number Of Nodes in MetaPath 68
Number Of Links MetaPath 67
Number of Shortest Paths 45269
Length Of Smallest Path 3
Average Path Length 14.573
Length of Longest Path 30
Minimum Path Strength 1.395
Average Path Strength 6.65454
Maximum Path Strength 26.4
Minimum Path Correlation 0.7
Average Path Correlation 0.920599
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 4.16667
Average % Of Corr. Nodes 42.9651
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 40.4405
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
Code7UR
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
Code7UR
Name4-[4-cyano-2-[[(2R)-2-(4-fluoranylnaphthalen-1-yl)propanoyl]amino]phenyl]butanoic acid
Synonyms
Identifier4-[4-cyano-2-[[(2~{R})-2-(4-fluoranylnaphthalen-1-yl)propanoyl]amino]phenyl]butanoic acid
FormulaC24 H21 F N2 O3
Molecular Weight404.434
SMILESC[C@H](c1ccc(c2c1cccc2)F)C(=O)Nc3cc(ccc3CCCC(=O)O)C#N
PubChem92978378
Formal Charge0
Total Atoms51
Total Chiral Atoms1
Total Bonds53
Total Aromatic Bonds17

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP35408
Sequence
>5YWY_Chain_R
NSPVTIPAV MFIFGVVGN LVAIVVLCK SRKEQKETT FYTLVCGLL 
VTDLLGTLL VSPVTIATY MKGQWPGGQ PLCEYSTFI LLFFSLSRL 
SIICAMSVE RYLAINHAY FYSHYVDKR LAGLTLFAV YASNVLFCA 
LPNMGLGSS RLQYPDTWC FIDWTTQVT AHAAYSYMY AGFSSFLIL 
ATVLCNVLV CGALLRMHA GAEIQMVIL LIATSLVVL ICSIPLVVR 
VFVNQLYQP SLEREVSKN PDLQAIRIA SVNPILDPW IYILLRKTV 
LSKAIEKIK C


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  



This network is also present in following consensuses:
IdComponents
ep4_off5YWY-EP4-ONO-AE3-208
5YHL-EP4-PubChem 135121352

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
5YHLALipidProstanoidEP4Homo sapiensPubChem 135121352--4.22018-12-0510.1038/s41589-018-0131-3
7D7MALipidProstanoidEP4Homo sapiensDinoprostone-Gs/&β;1/&γ;13.32020-11-1810.1016/j.str.2020.11.007
8GCMALipidProstanoidEP4Homo sapiensL902688-Gi1/&β;1/&γ;23.52024-01-0310.1073/pnas.2216329120
8GCPALipidProstanoidEP4Homo sapiensPGE2-Gi1/&β;1/&γ;23.12024-01-0310.1073/pnas.2216329120
8GD9ALipidProstanoidEP4Homo sapiensRivenprost-Gs/&β;1/&γ;23.22024-01-0310.1073/pnas.2216329120
8GDAALipidProstanoidEP4Homo sapiensL902688-Gs/&β;1/&γ;23.32024-01-0310.1073/pnas.2216329120
8GDBALipidProstanoidEP4Homo sapiensPGE2-Gs/&β;1/&γ;23.12024-01-0310.1073/pnas.2216329120




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Download 5YWY.zip



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