psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:P24	4.91	Yes	No	1	0	7
2	L:L:?1	R:R:M27	4.23	Yes	Yes	1	0	8
3	L:L:?1	R:R:T69	4.41	Yes	No	0	0	8
4	L:L:?1	R:R:V72	10.03	Yes	No	0	0	7
5	L:L:?1	R:R:S73	5.61	Yes	Yes	0	0	8
6	L:L:?1	R:R:T76	9.92	Yes	No	1	0	8
7	L:L:?1	R:R:Y80	5.26	Yes	Yes	1	0	6
8	L:L:?1	R:R:S103	5.61	Yes	No	0	0	7
9	L:L:?1	R:R:T168	7.72	Yes	Yes	1	0	6
10	L:L:?1	R:R:W169	6.81	Yes	Yes	1	0	5
11	L:L:?1	R:R:L312	7.25	Yes	No	1	0	6
12	L:L:?1	R:R:I315	3.2	Yes	No	1	0	6
13	L:L:?1	R:R:R316	3.63	Yes	Yes	1	0	7
14	L:L:?1	R:R:S319	8.98	Yes	No	1	0	8
15	L:L:?1	R:R:P322	3.68	Yes	No	0	0	9
16	R:R:P20	R:R:S19	3.56	No	No	0	5	1
17	R:R:S19	R:R:T22	3.2	No	No	0	1	5
18	R:R:V21	R:R:Y80	8.83	No	Yes	0	6	6
19	R:R:I23	R:R:P24	3.39	No	No	0	6	7
20	R:R:I23	R:R:R316	15.03	No	Yes	0	6	7
21	R:R:P24	R:R:T76	3.5	No	No	1	7	8
22	R:R:M27	R:R:R316	6.2	Yes	Yes	1	8	7
23	R:R:M27	R:R:S319	3.07	Yes	No	1	8	8
24	R:R:M27	R:R:V320	3.04	Yes	No	0	8	5
25	R:R:F28	R:R:V32	5.24	No	No	0	6	7
26	R:R:F28	R:R:S73	10.57	No	Yes	0	6	8
27	R:R:G31	R:R:I323	3.53	No	No	0	8	8
28	R:R:G34	R:R:V33	3.68	No	No	0	9	5
29	R:R:D65	R:R:N35	13.46	No	No	4	9	9
30	R:R:L66	R:R:N35	4.12	No	No	0	8	9
31	R:R:N35	R:R:P326	8.15	No	No	4	9	9
32	R:R:A38	R:R:I330	3.25	No	No	0	9	8
33	R:R:T335	R:R:V41	7.93	No	No	0	7	7
34	R:R:L42	R:R:Y55	4.69	No	Yes	5	8	8
35	R:R:C59	R:R:L42	4.76	No	No	5	6	8
36	R:R:K47	R:R:K50	17.24	No	No	0	6	7
37	R:R:K50	R:R:T52	4.5	No	No	0	7	7
38	R:R:K50	R:R:Y55	3.58	No	Yes	0	7	8
39	R:R:A136	R:R:T53	5.03	No	No	0	8	6
40	R:R:F54	R:R:V58	9.18	No	No	0	8	8
41	R:R:C59	R:R:Y55	6.72	No	Yes	5	6	8
42	R:R:L57	R:R:M113	5.65	No	Yes	0	8	9
43	R:R:M113	R:R:V58	3.04	Yes	No	0	9	8
44	R:R:I109	R:R:L61	5.71	No	No	0	8	9
45	R:R:L61	R:R:M113	4.24	No	Yes	0	9	9
46	R:R:D325	R:R:L61	5.43	No	No	0	9	9
47	R:R:S105	R:R:T64	6.4	No	No	0	8	9
48	R:R:I109	R:R:T64	3.04	No	No	0	8	9
49	R:R:T64	R:R:Y144	4.99	No	No	0	9	8
50	R:R:D65	R:R:P322	4.83	No	No	0	9	9
51	R:R:D65	R:R:P326	6.44	No	No	4	9	9
52	R:R:F102	R:R:L67	6.09	Yes	No	0	7	7
53	R:R:F102	R:R:G68	10.54	Yes	No	0	7	8
54	R:R:I98	R:R:L71	8.56	Yes	No	0	5	6
55	R:R:F102	R:R:L71	3.65	Yes	No	0	7	6
56	R:R:I98	R:R:V72	3.07	Yes	No	0	5	7
57	R:R:I77	R:R:S73	3.1	No	Yes	0	6	8
58	R:R:S95	R:R:V75	9.7	No	No	0	6	7
59	R:R:T79	R:R:W85	8.49	No	Yes	0	7	6
60	R:R:T168	R:R:T79	4.71	Yes	No	0	6	7
61	R:R:T168	R:R:Y80	13.73	Yes	Yes	1	6	6
62	R:R:K82	R:R:P86	6.69	No	No	0	5	4
63	R:R:G87	R:R:W85	4.22	No	Yes	2	5	6
64	R:R:L91	R:R:W85	3.42	No	Yes	2	6	6
65	R:R:D167	R:R:W85	10.05	No	Yes	0	5	6
66	R:R:G87	R:R:L91	6.84	No	No	2	5	6
67	R:R:P90	R:R:Q89	3.16	No	No	0	2	2
68	R:R:C170	R:R:C92	7.28	No	No	2	9	9
69	R:R:E93	R:R:N155	7.89	No	No	0	6	5
70	R:R:E93	R:R:S161	8.62	No	No	0	6	5
71	R:R:I98	R:R:Y94	8.46	Yes	No	0	5	5
72	R:R:S161	R:R:T96	6.4	No	No	0	5	7
73	R:R:F97	R:R:I98	3.77	No	Yes	0	7	5
74	R:R:F171	R:R:L100	3.65	Yes	No	0	6	7
75	R:R:I172	R:R:L100	4.28	No	No	0	7	7
76	R:R:L100	R:R:Y188	9.38	No	No	0	7	7
77	R:R:F101	R:R:F102	12.86	No	Yes	0	7	7
78	R:R:F101	R:R:V148	3.93	No	No	0	7	4
79	R:R:C151	R:R:F101	5.59	No	No	0	8	7
80	R:R:L104	R:R:N147	12.36	No	No	0	8	8
81	R:R:F150	R:R:L104	3.65	No	No	0	7	8
82	R:R:G106	R:R:S105	3.71	No	No	0	9	8
83	R:R:L107	R:R:L195	4.15	No	Yes	0	8	8
84	R:R:L107	R:R:S285	4.5	No	No	0	8	8
85	R:R:S108	R:R:V143	6.46	No	No	0	7	7
86	R:R:I110	R:R:T199	3.04	No	No	0	8	8
87	R:R:I110	R:R:V281	3.07	No	No	0	8	8
88	R:R:D325	R:R:I110	5.6	No	No	0	9	8
89	R:R:C111	R:R:L195	6.35	No	Yes	0	7	8
90	R:R:C111	R:R:T199	3.38	No	No	0	7	8
91	R:R:M113	R:R:Y329	5.99	Yes	No	0	9	9
92	R:R:S114	R:R:T199	7.99	No	No	0	9	8
93	R:R:C202	R:R:S114	5.16	No	No	0	7	9
94	R:R:N203	R:R:S114	7.45	Yes	No	0	9	9
95	R:R:C202	R:R:V115	3.42	No	No	0	7	7
96	R:R:E116	R:R:Y127	7.86	No	Yes	0	9	8
97	R:R:N203	R:R:R117	6.03	Yes	Yes	3	9	9
98	R:R:R117	R:R:V206	3.92	Yes	No	3	9	9
99	R:R:L274	R:R:R117	3.64	Yes	Yes	3	8	9
100	R:R:N122	R:R:Y118	11.63	No	Yes	7	7	8
101	R:R:H123	R:R:Y118	11.98	No	Yes	7	7	8
102	R:R:C202	R:R:Y118	5.38	No	Yes	0	7	8
103	R:R:F126	R:R:L119	8.53	No	No	0	5	6
104	R:R:A120	R:R:Y127	5.34	No	Yes	0	9	8
105	R:R:I121	R:R:V206	3.07	No	No	0	9	9
106	R:R:H123	R:R:N122	3.83	No	No	7	7	7
107	R:R:A209	R:R:N122	4.69	No	No	0	7	7
108	R:R:F126	R:R:Y130	11.35	No	No	0	5	5
109	R:R:V131	R:R:Y127	10.09	No	Yes	0	7	8
110	R:R:H129	R:R:Y130	8.71	No	No	0	5	5
111	R:R:L140	R:R:Y144	8.21	Yes	No	0	8	8
112	R:R:F150	R:R:Y184	10.32	No	Yes	0	7	8
113	R:R:F150	R:R:Y188	5.16	No	No	0	7	7
114	R:R:N155	R:R:P154	3.26	No	Yes	0	5	9
115	R:R:I172	R:R:P154	3.39	No	Yes	6	7	9
116	R:R:P154	R:R:Y184	9.74	Yes	Yes	6	9	8
117	R:R:A180	R:R:L158	4.73	No	No	0	3	5
118	R:R:H181	R:R:L158	3.86	Yes	No	0	5	5
119	R:R:G159	R:R:H181	6.35	No	Yes	0	7	5
120	R:R:D173	R:R:S160	5.89	Yes	No	1	5	3
121	R:R:S160	R:R:T176	7.99	No	No	1	3	4
122	R:R:H181	R:R:S160	8.37	Yes	No	0	5	3
123	R:R:D173	R:R:R162	11.91	Yes	No	0	5	4
124	R:R:D167	R:R:L163	8.14	No	No	0	5	4
125	R:R:Q164	R:R:Y165	3.38	Yes	No	0	7	3
126	R:R:Q164	R:R:W169	3.29	Yes	Yes	1	7	5
127	R:R:Q164	R:R:W174	7.67	Yes	Yes	1	7	5
128	R:R:N309	R:R:Q164	5.28	Yes	Yes	1	2	7
129	R:R:D311	R:R:Q164	7.83	Yes	Yes	1	6	7
130	R:R:L302	R:R:Y165	3.52	No	No	0	1	3
131	R:R:P166	R:R:T168	6.99	No	Yes	0	6	6
132	R:R:P166	R:R:V306	3.53	No	No	0	6	3
133	R:R:F171	R:R:W169	9.02	Yes	Yes	0	6	5
134	R:R:I315	R:R:W169	11.74	No	Yes	1	6	5
135	R:R:F171	R:R:W174	4.01	Yes	Yes	0	6	5
136	R:R:I172	R:R:Y184	7.25	No	Yes	6	7	8
137	R:R:D173	R:R:W174	3.35	Yes	Yes	1	5	5
138	R:R:D173	R:R:T175	5.78	Yes	No	0	5	4
139	R:R:D173	R:R:T176	10.12	Yes	No	1	5	4
140	R:R:N295	R:R:W174	10.17	Yes	Yes	1	6	5
141	R:R:D311	R:R:W174	6.7	Yes	Yes	1	6	5
142	R:R:P300	R:R:T175	6.99	No	No	0	1	4
143	R:R:T176	R:R:V178	3.17	No	No	0	4	3
144	R:R:H181	R:R:V178	16.61	Yes	No	0	5	3
145	R:R:Q296	R:R:S185	7.22	No	No	0	6	7
146	R:R:F293	R:R:Y186	4.13	No	No	0	6	5
147	R:R:Q296	R:R:Y186	11.27	No	No	0	6	5
148	R:R:F191	R:R:L195	3.65	No	Yes	0	6	8
149	R:R:S192	R:R:V289	6.46	No	No	0	7	7
150	R:R:I196	R:R:V281	4.61	No	No	0	7	8
151	R:R:I196	R:R:S285	9.29	No	No	0	7	8
152	R:R:L274	R:R:N203	8.24	Yes	Yes	3	8	9
153	R:R:N203	R:R:S278	4.47	Yes	No	0	9	8
154	R:R:L274	R:R:V206	4.47	Yes	No	3	8	9
155	R:R:C207	R:R:L274	3.17	No	Yes	0	7	8
156	R:R:A209	R:R:R212	4.15	No	No	0	7	4
157	R:R:E267	R:R:L210	10.6	Yes	No	0	8	9
158	R:R:F217	R:R:Q216	5.86	No	No	0	4	5
159	R:R:F217	R:R:R261	8.55	No	No	0	4	3
160	R:R:G265	R:R:I268	3.53	No	No	0	5	6
161	R:R:E267	R:R:V271	4.28	Yes	No	0	8	7
162	R:R:A276	R:R:I328	3.25	No	No	0	6	8
163	R:R:T277	R:R:Y329	6.24	No	No	0	8	9
164	R:R:I283	R:R:L279	4.28	No	No	0	7	6
165	R:R:L324	R:R:V280	4.47	No	No	0	7	6
166	R:R:I328	R:R:V280	3.07	No	No	0	8	6
167	R:R:I286	R:R:L282	4.28	No	No	0	7	6
168	R:R:C284	R:R:N321	4.72	No	No	0	9	9
169	R:R:I317	R:R:P287	3.39	No	No	0	8	9
170	R:R:A318	R:R:L288	4.73	No	No	0	8	7
171	R:R:V290	R:R:V294	3.21	No	No	0	7	5
172	R:R:R291	R:R:V294	5.23	Yes	No	0	6	5
173	R:R:N295	R:R:R291	15.67	Yes	Yes	1	6	6
174	R:R:D311	R:R:R291	9.53	Yes	Yes	1	6	6
175	R:R:N295	R:R:P300	4.89	Yes	No	0	6	1
176	R:R:D311	R:R:N295	5.39	Yes	Yes	1	6	6
177	R:R:L297	R:R:Y298	15.24	No	No	0	4	4
178	R:R:E303	R:R:N309	5.26	No	Yes	1	3	2
179	R:R:E303	R:R:P310	7.86	No	No	1	3	4
180	R:R:N309	R:R:P310	6.52	Yes	No	1	2	4
181	R:R:L312	R:R:N309	4.12	No	Yes	1	6	2
182	R:R:L312	R:R:R316	8.5	No	Yes	1	6	7
183	R:R:N321	R:R:P322	6.52	No	No	0	9	9
184	R:R:D325	R:R:N321	8.08	No	No	0	9	9
185	R:R:L331	R:R:W327	10.25	No	No	0	6	7
186	R:R:I328	R:R:Y329	4.84	No	No	0	8	9
187	R:R:L331	R:R:R333	9.72	No	No	0	6	9
188	R:R:K133	R:R:T56	3	No	No	0	5	6
189	R:R:L195	R:R:S108	3	Yes	No	0	8	7
190	R:R:L135	R:R:T139	2.95	No	No	0	5	7
191	R:R:I196	R:R:I286	2.94	No	No	0	7	7
192	R:R:I315	R:R:L288	2.85	No	No	0	6	7
193	R:R:I330	R:R:L331	2.85	No	No	0	8	6
194	R:R:G34	R:R:W327	2.81	No	No	0	9	7
195	R:R:P20	R:R:Y80	2.78	No	Yes	0	5	6
196	R:R:L66	R:R:L70	2.77	No	No	0	8	5
197	R:R:L201	R:R:L205	2.77	No	No	0	4	5
198	R:R:A314	R:R:R291	2.77	No	Yes	0	7	6
199	R:R:E267	R:R:M270	2.71	Yes	No	0	8	9
200	R:R:E51	R:R:K133	2.7	No	No	0	7	5
201	R:R:E342	R:R:K339	2.7	No	No	0	4	7
202	R:R:L332	R:R:Q269	2.66	No	No	0	8	8
203	R:R:F30	R:R:V26	2.62	No	No	0	5	5
204	R:R:C92	R:R:W85	2.61	No	Yes	2	9	6
205	R:R:C170	R:R:W85	2.61	No	Yes	2	9	6
206	R:R:H123	R:R:L119	2.57	No	No	0	7	6
207	R:R:S185	R:R:Y184	2.54	No	Yes	0	7	8
208	R:R:T53	R:R:Y127	2.5	No	Yes	0	6	8
209	R:R:M270	R:R:R117	2.48	No	Yes	0	9	9
210	R:R:V75	R:R:W85	2.45	No	Yes	0	7	6
211	R:R:F171	R:R:L99	2.44	Yes	No	0	6	8
212	R:R:F141	R:R:L140	2.44	No	Yes	0	4	8
213	R:R:L205	R:R:Y118	2.34	No	Yes	0	5	8
214	R:R:H129	R:R:Y125	2.18	No	No	0	5	7
215	R:R:F191	R:R:F194	2.14	No	No	0	6	4
216	R:R:R212	R:R:R215	2.13	No	No	0	4	6
217	R:R:G87	R:R:G88	2.11	No	No	0	5	5
218	R:R:G88	R:R:P90	2.03	No	No	0	5	2
219	R:R:C59	R:R:G60	1.96	No	No	0	6	8
220	R:R:C207	R:R:G208	1.96	No	No	0	7	3
221	R:R:A136	R:R:G137	1.95	No	No	0	8	5
222	R:R:A189	R:R:G190	1.95	No	No	0	7	5
223	R:R:A38	R:R:P326	1.87	No	No	0	9	9
224	R:R:A314	R:R:P287	1.87	No	No	0	7	9
225	R:R:G190	R:R:S193	1.86	No	No	0	5	6
226	R:R:A198	R:R:C111	1.81	No	No	0	6	7
227	R:R:P74	R:R:S73	1.78	No	Yes	0	9	8
228	R:R:G157	R:R:M156	1.75	No	No	0	8	5
229	R:R:G60	R:R:L140	1.71	No	Yes	0	8	8
230	R:R:G137	R:R:L140	1.71	No	Yes	0	5	8
231	R:R:A189	R:R:V292	1.7	No	No	0	7	7
232	R:R:A136	R:R:T56	1.68	No	No	0	8	6
233	R:R:G83	R:R:Q84	1.64	No	No	0	4	4
234	R:R:L153	R:R:P154	1.64	No	Yes	0	8	9
235	R:R:A62	R:R:I39	1.62	No	No	0	8	8
236	R:R:S193	R:R:V289	1.62	No	No	0	6	7
237	R:R:S278	R:R:V200	1.62	No	No	0	8	6
238	R:R:S285	R:R:V289	1.62	No	No	0	8	7
239	R:R:A340	R:R:K343	1.61	No	No	0	5	4
240	R:R:T139	R:R:V143	1.59	No	No	0	7	7
241	R:R:C207	R:R:L211	1.59	No	No	0	7	6
242	R:R:A112	R:R:L57	1.58	No	No	0	8	8
243	R:R:P300	R:R:Q299	1.58	No	No	0	1	2
244	R:R:I29	R:R:V33	1.54	No	No	0	5	5
245	R:R:K308	R:R:S307	1.53	No	No	0	4	4
246	R:R:A182	R:R:Q296	1.52	No	No	0	5	6
247	R:R:F30	R:R:G31	1.51	No	No	0	5	8
248	R:R:A264	R:R:E267	1.51	No	Yes	0	6	8
249	R:R:L197	R:R:S193	1.5	No	No	0	4	6
250	R:R:L36	R:R:V40	1.49	No	No	0	5	5
251	R:R:L42	R:R:V41	1.49	No	No	0	8	7
252	R:R:L201	R:R:V204	1.49	No	No	0	4	4
253	R:R:L138	R:R:T139	1.47	No	No	0	4	7
254	R:R:I283	R:R:I317	1.47	No	No	0	7	8
255	R:R:I39	R:R:L66	1.43	No	No	0	8	8
256	R:R:H129	R:R:S128	1.39	No	No	0	5	6
257	R:R:D132	R:R:K133	1.38	No	No	0	8	5
258	R:R:A264	R:R:R261	1.38	No	No	0	6	3
259	R:R:L273	R:R:L332	1.38	No	No	0	8	8
260	R:R:E267	R:R:I268	1.37	Yes	No	0	8	6
261	R:R:M270	R:R:Q269	1.36	No	No	0	9	8
262	R:R:K308	R:R:Q313	1.36	No	No	0	4	3
263	R:R:P86	R:R:W85	1.35	No	Yes	0	4	6
264	R:R:R46	R:R:S338	1.32	No	No	0	5	5
265	R:R:R333	R:R:V336	1.31	No	No	0	9	7
266	R:R:S45	R:R:Y55	1.27	No	Yes	0	6	8
267	R:R:F260	R:R:H214	1.13	No	No	0	4	5
268	L:L:?1	R:R:I323	1.07	Yes	No	0	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	5.77	16	1	0
2	R:R:M27	4.135	4	1	8
3	R:R:Y55	4.065	4	5	8
4	R:R:S73	5.265	4	0	8
5	R:R:Y80	7.65	4	1	6
6	R:R:W85	4.4	8	2	6
7	R:R:I98	5.965	4	0	5
8	R:R:F102	8.285	4	0	7
9	R:R:M113	4.73	4	0	9
10	R:R:R117	4.0175	4	3	9
11	R:R:Y118	7.8325	4	7	8
12	R:R:Y127	6.4475	4	0	8
13	R:R:L140	3.5175	4	0	8
14	R:R:P154	4.5075	4	6	9
15	R:R:Q164	5.49	5	1	7
16	R:R:T168	8.2875	4	1	6
17	R:R:W169	7.715	4	1	5
18	R:R:F171	4.78	4	0	6
19	R:R:D173	7.41	5	1	5
20	R:R:W174	6.38	5	1	5
21	R:R:H181	8.7975	4	0	5
22	R:R:Y184	7.4625	4	6	8
23	R:R:L195	4.2875	4	0	8
24	R:R:N203	6.5475	4	3	9
25	R:R:E267	4.094	5	0	8
26	R:R:L274	4.88	4	3	8
27	R:R:R291	8.3	4	1	6
28	R:R:N295	9.03	4	1	6
29	R:R:N309	5.295	4	1	2
30	R:R:D311	7.3625	4	1	6
31	R:R:R316	8.34	4	1	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:P322	100	3.68	Yes	No	0	0	9
2	R:R:D65	R:R:P322	23.8803	4.83	No	No	0	9	9
3	R:R:D65	R:R:P326	14.9856	6.44	No	No	4	9	9
4	R:R:A38	R:R:P326	13.8251	1.87	No	No	0	9	9
5	R:R:A38	R:R:I330	12.3385	3.25	No	No	0	9	8
6	R:R:I330	R:R:L331	10.8393	2.85	No	No	0	8	6
7	R:R:N321	R:R:P322	98.7141	6.52	No	No	0	9	9
8	R:R:D325	R:R:N321	98.3126	8.08	No	No	0	9	9
9	R:R:D325	R:R:L61	52.9231	5.43	No	No	0	9	9
10	R:R:I109	R:R:L61	38.9788	5.71	No	No	0	8	9
11	R:R:I109	R:R:T64	37.7305	3.04	No	No	0	8	9
12	R:R:T64	R:R:Y144	33.8979	4.99	No	No	0	9	8
13	R:R:L140	R:R:Y144	32.5994	8.21	Yes	No	0	8	8
14	R:R:G60	R:R:L140	14.7472	1.71	No	Yes	0	8	8
15	R:R:C59	R:R:G60	13.2731	1.96	No	No	0	6	8
16	R:R:G137	R:R:L140	16.491	1.71	No	Yes	0	5	8
17	R:R:A136	R:R:G137	15.0295	1.95	No	No	0	8	5
18	R:R:L61	R:R:M113	16.6416	4.24	No	Yes	0	9	9
19	L:L:?1	R:R:V72	16.7608	10.03	Yes	No	0	0	7
20	R:R:I98	R:R:V72	15.2992	3.07	Yes	No	0	5	7
21	R:R:I98	R:R:L71	10.8393	8.56	Yes	No	0	5	6
22	L:L:?1	R:R:T168	25.9629	7.72	Yes	Yes	1	0	6
23	R:R:T168	R:R:T79	22.4815	4.71	Yes	No	0	6	7
24	R:R:T79	R:R:W85	21.0701	8.49	No	Yes	0	7	6
25	L:L:?1	R:R:W169	72.5693	6.81	Yes	Yes	1	0	5
26	R:R:F171	R:R:W169	40.1832	9.02	Yes	Yes	0	6	5
27	R:R:F171	R:R:L100	26.0005	3.65	Yes	No	0	6	7
28	R:R:I172	R:R:L100	19.1068	4.28	No	No	0	7	7
29	R:R:D325	R:R:I110	79.4881	5.6	No	No	0	9	8
30	R:R:I110	R:R:T199	66.9991	3.04	No	No	0	8	8
31	R:R:C111	R:R:T199	18.1721	3.38	No	No	0	7	8
32	R:R:C111	R:R:L195	15.4874	6.35	No	Yes	0	7	8
33	R:R:I110	R:R:V281	18.5736	3.07	No	No	0	8	8
34	R:R:I196	R:R:V281	17.1936	4.61	No	No	0	7	8
35	R:R:I196	R:R:S285	13.1665	9.29	No	No	0	7	8
36	R:R:S114	R:R:T199	58.2173	7.99	No	No	0	9	8
37	R:R:C202	R:R:S114	25.8939	5.16	No	No	0	7	9
38	R:R:N203	R:R:S114	36.5073	7.45	Yes	No	0	9	9
39	R:R:N203	R:R:R117	23.5855	6.03	Yes	Yes	3	9	9
40	R:R:C202	R:R:Y118	23.021	5.38	No	Yes	0	7	8
41	R:R:H123	R:R:Y118	10.971	11.98	No	Yes	7	7	8
42	R:R:Q164	R:R:W169	34.4185	3.29	Yes	Yes	1	7	5
43	R:R:Q164	R:R:W174	17.8209	7.67	Yes	Yes	1	7	5
44	R:R:D173	R:R:W174	26.358	3.35	Yes	Yes	1	5	5
45	R:R:D173	R:R:S160	13.386	5.89	Yes	No	1	5	3
46	R:R:H181	R:R:S160	10.764	8.37	Yes	No	0	5	3
47	R:R:F171	R:R:W174	20.8569	4.01	Yes	Yes	0	6	5
48	R:R:D311	R:R:Q164	14.3897	7.83	Yes	Yes	1	6	7
49	R:R:S285	R:R:V289	12.7274	1.62	No	No	0	8	7
50	R:R:M270	R:R:R117	19.6086	2.48	No	Yes	0	9	9
51	R:R:E267	R:R:M270	13.9506	2.71	Yes	No	0	8	9
52	R:R:D311	R:R:R291	11.2282	9.53	Yes	Yes	1	6	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:P24	4.91	1	Yes	No	0	7	0	1
L:L:?1	R:R:M27	4.23	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:T69	4.41	1	Yes	No	0	8	0	1
L:L:?1	R:R:V72	10.03	1	Yes	No	0	7	0	1
L:L:?1	R:R:S73	5.61	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:T76	9.92	1	Yes	No	0	8	0	1
L:L:?1	R:R:Y80	5.26	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:S103	5.61	1	Yes	No	0	7	0	1
L:L:?1	R:R:T168	7.72	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:W169	6.81	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:L312	7.25	1	Yes	No	0	6	0	1
L:L:?1	R:R:I315	3.2	1	Yes	No	0	6	0	1
L:L:?1	R:R:R316	3.63	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:S319	8.98	1	Yes	No	0	8	0	1
L:L:?1	R:R:P322	3.68	1	Yes	No	0	9	0	1
R:R:V21	R:R:Y80	8.83	0	No	Yes	6	6	2	1
R:R:I23	R:R:P24	3.39	0	No	No	6	7	2	1
R:R:I23	R:R:R316	15.03	0	No	Yes	6	7	2	1
R:R:P24	R:R:T76	3.5	1	No	No	7	8	1	1
R:R:M27	R:R:R316	6.2	1	Yes	Yes	8	7	1	1
R:R:M27	R:R:S319	3.07	1	Yes	No	8	8	1	1
R:R:M27	R:R:V320	3.04	1	Yes	No	8	5	1	2
R:R:F28	R:R:S73	10.57	0	No	Yes	6	8	2	1
R:R:G31	R:R:I323	3.53	0	No	No	8	8	2	1
R:R:D65	R:R:P322	4.83	4	No	No	9	9	2	1
R:R:I98	R:R:V72	3.07	0	Yes	No	5	7	2	1
R:R:I77	R:R:S73	3.1	0	No	Yes	6	8	2	1
R:R:T168	R:R:T79	4.71	1	Yes	No	6	7	1	2
R:R:T168	R:R:Y80	13.73	1	Yes	Yes	6	6	1	1
R:R:Q164	R:R:W169	3.29	1	Yes	Yes	7	5	2	1
R:R:N309	R:R:Q164	5.28	1	Yes	Yes	2	7	2	2
R:R:P166	R:R:T168	6.99	0	No	Yes	6	6	2	1
R:R:F171	R:R:W169	9.02	0	Yes	Yes	6	5	2	1
R:R:I315	R:R:W169	11.74	1	No	Yes	6	5	1	1
R:R:L312	R:R:N309	4.12	1	No	Yes	6	2	1	2
R:R:L312	R:R:R316	8.5	1	No	Yes	6	7	1	1
R:R:N321	R:R:P322	6.52	0	No	No	9	9	2	1
R:R:I315	R:R:L288	2.85	1	No	No	6	7	1	2
R:R:P20	R:R:Y80	2.78	0	No	Yes	5	6	2	1
R:R:P74	R:R:S73	1.78	0	No	Yes	9	8	2	1
L:L:?1	R:R:I323	1.07	1	Yes	No	0	8	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7D7M_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.04
Number of Linked Nodes	252
Number of Links	268
Number of Hubs	31
Number of Links mediated by Hubs	120
Number of Communities	7
Number of Nodes involved in Communities	43
Number of Links involved in Communities	56

Path Summary
Number Of Nodes in MetaPath	53
Number Of Links MetaPath	52
Number of Shortest Paths	31259
Length Of Smallest Path	3
Average Path Length	12.0296
Length of Longest Path	24
Minimum Path Strength	1.42
Average Path Strength	5.40158
Maximum Path Strength	12.92
Minimum Path Correlation	0.7
Average Path Correlation	0.929365
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	5
Average % Of Corr. Nodes	55.2847
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	32.0444
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	P2E
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	P2E
Name	Dinoprostone
Synonyms	Dinoprostona
Identifier
Formula	C20 H32 O5
Molecular Weight	352.465
SMILES
PubChem	5280360
Formal Charge	0
Total Atoms	57
Total Chiral Atoms	4
Total Bonds	57
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P35408
Sequence	>7D7M_nogp_Chain_R S P V T I P A V M F I F G V V G N L V A I V V L C K S R K E Q K E T T F Y T L V C G L A V T D L L G T L L V S P V T I A T Y M K G Q W P G G Q P L C E Y S T F I L L F F S L S G L S I I C A M S V E R Y L A I N H A Y F Y S H Y V D K R L A G L T L F A V Y A S N V L F C A L P N M G L G S S R L Q Y P D T W C F I D W T T Q V T A H A A Y S Y M Y A G F S S F L I L A T V L C N V L V C G A L L R M H R Q F F R R I A G A E I Q M V I L L I A T S L V V L I C S I P L V V R V F V N Q L Y Q P S L E R E V S K N P D L Q A I R I A S V N P I L D P W I Y I L L R K T V L S K A I E K I K Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7D7M	A	Lipid	Prostanoid	EP₄	Homo sapiens	Dinoprostone	-	Gs/β1/γ1	3.3	2020-11-18	doi.org/10.1016/j.str.2020.11.007
	7D7M (No Gprot)	A	Lipid	Prostanoid	EP₄	Homo sapiens	Dinoprostone	-		3.3	2020-11-18	doi.org/10.1016/j.str.2020.11.007
	5YHL	A	Lipid	Prostanoid	EP₄	Homo sapiens	PubChem 135121352	-	-	4.2	2018-12-05	doi.org/10.1038/s41589-018-0131-3
	5YWY	A	Lipid	Prostanoid	EP₄	Homo sapiens	ONO-AE3-208	-	-	3.2	2018-12-05	doi.org/10.1038/s41589-018-0131-3
	8GCM	A	Lipid	Prostanoid	EP₄	Homo sapiens	L902688	-	Gi1/β1/γ2	3.5	2024-01-03	doi.org/10.1073/pnas.2216329120
	8GCM (No Gprot)	A	Lipid	Prostanoid	EP₄	Homo sapiens	L902688	-		3.5	2024-01-03	doi.org/10.1073/pnas.2216329120
	8GCP	A	Lipid	Prostanoid	EP₄	Homo sapiens	PGE2	-	Gi1/β1/γ2	3.1	2024-01-03	doi.org/10.1073/pnas.2216329120
	8GCP (No Gprot)	A	Lipid	Prostanoid	EP₄	Homo sapiens	PGE2	-		3.1	2024-01-03	doi.org/10.1073/pnas.2216329120
	8GD9	A	Lipid	Prostanoid	EP₄	Homo sapiens	Rivenprost	-	Gs/β1/γ2	3.2	2024-01-03	doi.org/10.1073/pnas.2216329120
	8GD9 (No Gprot)	A	Lipid	Prostanoid	EP₄	Homo sapiens	Rivenprost	-		3.2	2024-01-03	doi.org/10.1073/pnas.2216329120
	8GDA	A	Lipid	Prostanoid	EP₄	Homo sapiens	L902688	-	Gs/β1/γ2	3.3	2024-01-03	doi.org/10.1073/pnas.2216329120
	8GDA (No Gprot)	A	Lipid	Prostanoid	EP₄	Homo sapiens	L902688	-		3.3	2024-01-03	doi.org/10.1073/pnas.2216329120
	8GDB	A	Lipid	Prostanoid	EP₄	Homo sapiens	PGE2	-	Gs/β1/γ2	3.1	2024-01-03	doi.org/10.1073/pnas.2216329120
	8GDB (No Gprot)	A	Lipid	Prostanoid	EP₄	Homo sapiens	PGE2	-		3.1	2024-01-03	doi.org/10.1073/pnas.2216329120

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