Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 6AK3 | A | Lipid | Prostanoid | EP3 | Homo sapiens | Dinoprostone IPGE2 | - | - | 2.9 | 2018-12-05 | 10.1038/s41589-018-0171-8 |
![](/psngpcr/ligands/P2E/P2E_6AK3_L_L_1.png)
A 2D representation of the interactions of P2E in 6AK3 colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:V50 | R:R:Y114 | 3.79 | 1 | Yes | Yes | 4 | 8 | 2 | 1 | R:R:V50 | R:R:W203 | 3.68 | 1 | Yes | Yes | 4 | 4 | 2 | 2 | R:R:P204 | R:R:V50 | 8.84 | 1 | No | Yes | 7 | 4 | 2 | 2 | R:R:V52 | R:R:Y114 | 10.09 | 0 | No | Yes | 5 | 8 | 2 | 1 | R:R:F54 | R:R:R333 | 17.1 | 0 | No | Yes | 4 | 8 | 2 | 1 | R:R:P55 | R:R:V110 | 3.53 | 1 | No | No | 7 | 8 | 1 | 1 | L:L:?1 | R:R:P55 | 3.41 | 1 | Yes | No | 0 | 7 | 0 | 1 | R:R:M58 | R:R:R333 | 3.72 | 1 | No | Yes | 8 | 8 | 1 | 1 | R:R:I340 | R:R:M58 | 4.37 | 0 | No | No | 9 | 8 | 2 | 1 | L:L:?1 | R:R:M58 | 8.81 | 1 | Yes | No | 0 | 8 | 0 | 1 | R:R:L59 | R:R:T107 | 13.27 | 0 | No | No | 7 | 8 | 2 | 1 | R:R:D99 | R:R:S144 | 4.42 | 1 | Yes | No | 9 | 8 | 2 | 2 | R:R:D99 | R:R:Q339 | 10.44 | 1 | Yes | Yes | 9 | 8 | 2 | 1 | R:R:D342 | R:R:D99 | 7.98 | 1 | Yes | Yes | 9 | 9 | 2 | 2 | R:R:F133 | R:R:T106 | 6.49 | 3 | Yes | No | 6 | 6 | 2 | 1 | R:R:T106 | R:R:T136 | 3.14 | 0 | No | No | 6 | 5 | 1 | 2 | L:L:?1 | R:R:T106 | 5.1 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:P108 | R:R:T107 | 3.5 | 0 | No | No | 8 | 8 | 2 | 1 | L:L:?1 | R:R:T107 | 12.24 | 1 | Yes | No | 0 | 8 | 0 | 1 | R:R:T206 | R:R:V110 | 3.17 | 1 | Yes | No | 8 | 8 | 1 | 1 | L:L:?1 | R:R:V110 | 6.19 | 1 | Yes | No | 0 | 8 | 0 | 1 | R:R:T206 | R:R:V113 | 4.76 | 1 | Yes | No | 8 | 7 | 1 | 2 | R:R:T206 | R:R:Y114 | 14.98 | 1 | Yes | Yes | 8 | 8 | 1 | 1 | L:L:?1 | R:R:Y114 | 7.3 | 1 | Yes | Yes | 0 | 8 | 0 | 1 | R:R:F133 | R:R:M137 | 4.98 | 3 | Yes | No | 6 | 7 | 2 | 1 | L:L:?1 | R:R:M137 | 9.79 | 1 | Yes | No | 0 | 7 | 0 | 1 | R:R:Q339 | R:R:S144 | 8.66 | 1 | Yes | No | 8 | 8 | 1 | 2 | R:R:D342 | R:R:S144 | 5.89 | 1 | Yes | No | 9 | 8 | 2 | 2 | R:R:L145 | R:R:W295 | 20.5 | 0 | No | Yes | 8 | 8 | 2 | 1 | R:R:Q202 | R:R:W207 | 16.43 | 1 | No | Yes | 8 | 7 | 2 | 1 | R:R:F209 | R:R:Q202 | 3.51 | 1 | No | No | 8 | 8 | 2 | 2 | R:R:F328 | R:R:Q202 | 3.51 | 1 | Yes | No | 6 | 8 | 2 | 2 | R:R:P204 | R:R:W203 | 20.27 | 1 | No | Yes | 7 | 4 | 2 | 2 | R:R:L329 | R:R:W203 | 4.56 | 1 | Yes | Yes | 7 | 4 | 1 | 2 | R:R:P204 | R:R:T206 | 3.5 | 1 | No | Yes | 7 | 8 | 2 | 1 | R:R:T206 | R:R:W207 | 3.64 | 1 | Yes | Yes | 8 | 7 | 1 | 1 | L:L:?1 | R:R:T206 | 7.14 | 1 | Yes | Yes | 0 | 8 | 0 | 1 | R:R:F209 | R:R:W207 | 5.01 | 1 | No | Yes | 8 | 7 | 2 | 1 | R:R:F328 | R:R:W207 | 5.01 | 1 | Yes | Yes | 6 | 7 | 2 | 1 | R:R:L329 | R:R:W207 | 4.56 | 1 | Yes | Yes | 7 | 7 | 1 | 1 | R:R:V332 | R:R:W207 | 13.48 | 1 | No | Yes | 7 | 7 | 1 | 1 | L:L:?1 | R:R:W207 | 11.04 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:F209 | R:R:F328 | 3.22 | 1 | No | Yes | 8 | 6 | 2 | 2 | R:R:L299 | R:R:W295 | 3.42 | 0 | No | Yes | 8 | 8 | 2 | 1 | R:R:A335 | R:R:W295 | 7.78 | 0 | No | Yes | 8 | 8 | 2 | 1 | R:R:N338 | R:R:W295 | 9.04 | 1 | Yes | Yes | 9 | 8 | 2 | 1 | R:R:Q339 | R:R:W295 | 4.38 | 1 | Yes | Yes | 8 | 8 | 1 | 1 | L:L:?1 | R:R:W295 | 3.15 | 1 | Yes | Yes | 0 | 8 | 0 | 1 | R:R:L329 | R:R:R333 | 12.15 | 1 | Yes | Yes | 7 | 8 | 1 | 1 | L:L:?1 | R:R:L329 | 5.75 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | L:L:?1 | R:R:V332 | 6.19 | 1 | Yes | No | 0 | 7 | 0 | 1 | L:L:?1 | R:R:R333 | 5.05 | 1 | Yes | Yes | 0 | 8 | 0 | 1 | L:L:?1 | R:R:S336 | 19.75 | 1 | Yes | No | 0 | 8 | 0 | 1 | R:R:N338 | R:R:Q339 | 7.92 | 1 | Yes | Yes | 9 | 8 | 2 | 1 | R:R:D342 | R:R:N338 | 6.73 | 1 | Yes | Yes | 9 | 9 | 2 | 2 | R:R:D342 | R:R:Q339 | 3.92 | 1 | Yes | Yes | 9 | 8 | 2 | 1 | L:L:?1 | R:R:Q339 | 9.21 | 1 | Yes | Yes | 0 | 8 | 0 | 1 | R:R:G141 | R:R:W295 | 2.81 | 0 | No | Yes | 7 | 8 | 2 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 15.00 | Average Number Of Links With An Hub | 7.00 | Average Interaction Strength | 8.01 | Average Nodes In Shell | 38.00 | Average Hubs In Shell | 15.00 | Average Links In Shell | 58.00 | Average Links Mediated by Hubs In Shell | 52.00 |
| ![](/psngpcr/ligands/P2E/P2E_6AK3_L_L_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/P2E/P2E_6AK3_L_L_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 6AK3_poly | A | Lipid | Prostanoid | EP3 | Homo sapiens | Dinoprostone IPGE2 | - | - | 2.9 | 2018-12-05 | 10.1038/s41589-018-0171-8 |
![](/psngpcr/ligands/P2E/P2E_6AK3_poly_M_M_1.png)
A 2D representation of the interactions of P2E in 6AK3_poly colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | S:S:V50 | S:S:Y114 | 3.79 | 1 | Yes | Yes | 4 | 8 | 2 | 1 | S:S:V50 | S:S:W203 | 3.68 | 1 | Yes | Yes | 4 | 4 | 2 | 2 | S:S:P204 | S:S:V50 | 8.84 | 1 | No | Yes | 7 | 4 | 2 | 2 | S:S:I111 | S:S:V52 | 4.61 | 0 | No | No | 7 | 5 | 2 | 2 | S:S:V52 | S:S:Y114 | 10.09 | 0 | No | Yes | 5 | 8 | 2 | 1 | S:S:F54 | S:S:R333 | 17.1 | 0 | Yes | Yes | 4 | 8 | 2 | 1 | S:S:P55 | S:S:V110 | 3.53 | 1 | No | No | 7 | 8 | 1 | 1 | M:M:?1 | S:S:P55 | 3.41 | 1 | Yes | No | 0 | 7 | 0 | 1 | S:S:M58 | S:S:R333 | 3.72 | 1 | No | Yes | 8 | 8 | 1 | 1 | S:S:I340 | S:S:M58 | 4.37 | 0 | No | No | 9 | 8 | 2 | 1 | M:M:?1 | S:S:M58 | 8.81 | 1 | Yes | No | 0 | 8 | 0 | 1 | S:S:L59 | S:S:T107 | 13.27 | 0 | No | Yes | 7 | 8 | 2 | 1 | S:S:D99 | S:S:S144 | 4.42 | 1 | Yes | No | 9 | 8 | 2 | 2 | S:S:D99 | S:S:Q339 | 10.44 | 1 | Yes | Yes | 9 | 8 | 2 | 1 | S:S:D342 | S:S:D99 | 7.98 | 1 | Yes | Yes | 9 | 9 | 2 | 2 | S:S:F133 | S:S:T106 | 6.49 | 6 | Yes | No | 6 | 6 | 2 | 1 | S:S:T106 | S:S:T136 | 3.14 | 0 | No | No | 6 | 5 | 1 | 2 | M:M:?1 | S:S:T106 | 5.1 | 1 | Yes | No | 0 | 6 | 0 | 1 | S:S:P108 | S:S:T107 | 3.5 | 0 | No | Yes | 8 | 8 | 2 | 1 | S:S:I111 | S:S:T107 | 3.04 | 0 | No | Yes | 7 | 8 | 2 | 1 | M:M:?1 | S:S:T107 | 12.24 | 1 | Yes | Yes | 0 | 8 | 0 | 1 | S:S:T206 | S:S:V110 | 3.17 | 1 | Yes | No | 8 | 8 | 1 | 1 | M:M:?1 | S:S:V110 | 6.19 | 1 | Yes | No | 0 | 8 | 0 | 1 | S:S:T206 | S:S:V113 | 4.76 | 1 | Yes | No | 8 | 7 | 1 | 2 | S:S:T206 | S:S:Y114 | 14.98 | 1 | Yes | Yes | 8 | 8 | 1 | 1 | M:M:?1 | S:S:Y114 | 7.3 | 1 | Yes | Yes | 0 | 8 | 0 | 1 | S:S:F133 | S:S:M137 | 4.98 | 6 | Yes | No | 6 | 7 | 2 | 1 | M:M:?1 | S:S:M137 | 9.79 | 1 | Yes | No | 0 | 7 | 0 | 1 | S:S:Q339 | S:S:S144 | 8.66 | 1 | Yes | No | 8 | 8 | 1 | 2 | S:S:D342 | S:S:S144 | 5.89 | 1 | Yes | No | 9 | 8 | 2 | 2 | S:S:L145 | S:S:W295 | 20.5 | 0 | No | Yes | 8 | 8 | 2 | 1 | S:S:Q202 | S:S:W207 | 16.43 | 1 | No | Yes | 8 | 7 | 2 | 1 | S:S:F209 | S:S:Q202 | 3.51 | 1 | No | No | 8 | 8 | 2 | 2 | S:S:F328 | S:S:Q202 | 3.51 | 1 | Yes | No | 6 | 8 | 2 | 2 | S:S:P204 | S:S:W203 | 20.27 | 1 | No | Yes | 7 | 4 | 2 | 2 | S:S:L329 | S:S:W203 | 4.56 | 1 | Yes | Yes | 7 | 4 | 1 | 2 | S:S:P204 | S:S:T206 | 3.5 | 1 | No | Yes | 7 | 8 | 2 | 1 | S:S:T206 | S:S:W207 | 3.64 | 1 | Yes | Yes | 8 | 7 | 1 | 1 | M:M:?1 | S:S:T206 | 7.14 | 1 | Yes | Yes | 0 | 8 | 0 | 1 | S:S:F209 | S:S:W207 | 5.01 | 1 | No | Yes | 8 | 7 | 2 | 1 | S:S:F328 | S:S:W207 | 5.01 | 1 | Yes | Yes | 6 | 7 | 2 | 1 | S:S:L329 | S:S:W207 | 4.56 | 1 | Yes | Yes | 7 | 7 | 1 | 1 | S:S:V332 | S:S:W207 | 13.48 | 1 | No | Yes | 7 | 7 | 1 | 1 | M:M:?1 | S:S:W207 | 11.04 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | S:S:F209 | S:S:F328 | 3.22 | 1 | No | Yes | 8 | 6 | 2 | 2 | S:S:L299 | S:S:W295 | 3.42 | 0 | No | Yes | 8 | 8 | 2 | 1 | S:S:A335 | S:S:W295 | 7.78 | 0 | No | Yes | 8 | 8 | 2 | 1 | S:S:N338 | S:S:W295 | 9.04 | 1 | Yes | Yes | 9 | 8 | 2 | 1 | S:S:Q339 | S:S:W295 | 4.38 | 1 | Yes | Yes | 8 | 8 | 1 | 1 | M:M:?1 | S:S:W295 | 3.15 | 1 | Yes | Yes | 0 | 8 | 0 | 1 | S:S:L329 | S:S:R333 | 12.15 | 1 | Yes | Yes | 7 | 8 | 1 | 1 | M:M:?1 | S:S:L329 | 5.75 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | M:M:?1 | S:S:V332 | 6.19 | 1 | Yes | No | 0 | 7 | 0 | 1 | M:M:?1 | S:S:R333 | 5.05 | 1 | Yes | Yes | 0 | 8 | 0 | 1 | M:M:?1 | S:S:S336 | 19.75 | 1 | Yes | No | 0 | 8 | 0 | 1 | S:S:N338 | S:S:Q339 | 7.92 | 1 | Yes | Yes | 9 | 8 | 2 | 1 | S:S:D342 | S:S:N338 | 6.73 | 1 | Yes | Yes | 9 | 9 | 2 | 2 | S:S:D342 | S:S:Q339 | 3.92 | 1 | Yes | Yes | 9 | 8 | 2 | 1 | M:M:?1 | S:S:Q339 | 9.21 | 1 | Yes | Yes | 0 | 8 | 0 | 1 | S:S:G141 | S:S:W295 | 2.81 | 0 | No | Yes | 7 | 8 | 2 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 15.00 | Average Number Of Links With An Hub | 8.00 | Average Interaction Strength | 8.01 | Average Nodes In Shell | 39.00 | Average Hubs In Shell | 17.00 | Average Links In Shell | 60.00 | Average Links Mediated by Hubs In Shell | 55.00 |
| ![](/psngpcr/ligands/P2E/P2E_6AK3_poly_M_M_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/P2E/P2E_6AK3_poly_M_M_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
![](/psngpcr/ligands/P2E/P2E_6AK3_poly_L_L_1.png)
A 2D representation of the interactions of P2E in 6AK3_poly colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:L329 | R:R:S49 | 4.5 | 2 | Yes | No | 7 | 4 | 1 | 2 | R:R:V50 | R:R:Y114 | 3.79 | 0 | No | Yes | 4 | 8 | 2 | 1 | R:R:P204 | R:R:V50 | 8.84 | 0 | No | No | 7 | 4 | 2 | 2 | R:R:I111 | R:R:V52 | 4.61 | 0 | No | No | 7 | 5 | 2 | 2 | R:R:V52 | R:R:Y114 | 10.09 | 0 | No | Yes | 5 | 8 | 2 | 1 | R:R:F54 | R:R:R333 | 17.1 | 0 | Yes | Yes | 4 | 8 | 2 | 1 | R:R:P55 | R:R:V110 | 3.53 | 2 | No | No | 7 | 8 | 1 | 1 | L:L:?1 | R:R:P55 | 3.41 | 2 | Yes | No | 0 | 7 | 0 | 1 | R:R:M58 | R:R:R333 | 3.72 | 2 | No | Yes | 8 | 8 | 1 | 1 | R:R:I340 | R:R:M58 | 4.37 | 0 | No | No | 9 | 8 | 2 | 1 | L:L:?1 | R:R:M58 | 9.79 | 2 | Yes | No | 0 | 8 | 0 | 1 | R:R:L59 | R:R:T107 | 13.27 | 0 | No | Yes | 7 | 8 | 2 | 1 | R:R:G62 | R:R:Q103 | 4.93 | 0 | No | No | 9 | 8 | 2 | 1 | R:R:G62 | R:R:I340 | 3.53 | 0 | No | No | 9 | 9 | 2 | 2 | R:R:D99 | R:R:N66 | 5.39 | 2 | Yes | Yes | 9 | 9 | 2 | 2 | R:R:N66 | R:R:Q103 | 3.96 | 0 | Yes | No | 9 | 8 | 2 | 1 | R:R:D99 | R:R:Q339 | 10.44 | 2 | Yes | Yes | 9 | 8 | 2 | 1 | R:R:D342 | R:R:D99 | 7.98 | 2 | Yes | Yes | 9 | 9 | 2 | 2 | L:L:?1 | R:R:Q103 | 5.53 | 2 | Yes | No | 0 | 8 | 0 | 1 | R:R:F133 | R:R:T106 | 6.49 | 5 | Yes | No | 6 | 6 | 2 | 1 | R:R:T106 | R:R:T136 | 3.14 | 0 | No | No | 6 | 5 | 1 | 2 | L:L:?1 | R:R:T106 | 5.1 | 2 | Yes | No | 0 | 6 | 0 | 1 | R:R:P108 | R:R:T107 | 3.5 | 0 | No | Yes | 8 | 8 | 2 | 1 | R:R:I111 | R:R:T107 | 3.04 | 0 | No | Yes | 7 | 8 | 2 | 1 | L:L:?1 | R:R:T107 | 11.22 | 2 | Yes | Yes | 0 | 8 | 0 | 1 | L:L:?1 | R:R:V110 | 6.19 | 2 | Yes | No | 0 | 8 | 0 | 1 | R:R:T206 | R:R:V113 | 4.76 | 2 | Yes | No | 8 | 7 | 1 | 2 | R:R:T206 | R:R:Y114 | 14.98 | 2 | Yes | Yes | 8 | 8 | 1 | 1 | L:L:?1 | R:R:Y114 | 7.3 | 2 | Yes | Yes | 0 | 8 | 0 | 1 | R:R:F133 | R:R:M137 | 6.22 | 5 | Yes | No | 6 | 7 | 2 | 1 | R:R:G134 | R:R:M137 | 3.49 | 0 | No | No | 7 | 7 | 2 | 1 | L:L:?1 | R:R:M137 | 10.77 | 2 | Yes | No | 0 | 7 | 0 | 1 | R:R:Q339 | R:R:S144 | 8.66 | 2 | Yes | No | 8 | 8 | 1 | 2 | R:R:D342 | R:R:S144 | 5.89 | 2 | Yes | No | 9 | 8 | 2 | 2 | R:R:Q202 | R:R:W207 | 16.43 | 2 | Yes | Yes | 8 | 7 | 2 | 1 | R:R:F209 | R:R:Q202 | 3.51 | 2 | No | Yes | 8 | 8 | 2 | 2 | R:R:F328 | R:R:Q202 | 3.51 | 2 | Yes | Yes | 6 | 8 | 2 | 2 | R:R:P204 | R:R:W203 | 20.27 | 0 | No | Yes | 7 | 4 | 2 | 2 | R:R:L329 | R:R:W203 | 4.56 | 2 | Yes | Yes | 7 | 4 | 1 | 2 | R:R:P204 | R:R:T206 | 3.5 | 0 | No | Yes | 7 | 8 | 2 | 1 | R:R:T206 | R:R:W207 | 3.64 | 2 | Yes | Yes | 8 | 7 | 1 | 1 | L:L:?1 | R:R:T206 | 6.12 | 2 | Yes | Yes | 0 | 8 | 0 | 1 | R:R:F209 | R:R:W207 | 5.01 | 2 | No | Yes | 8 | 7 | 2 | 1 | R:R:F328 | R:R:W207 | 5.01 | 2 | Yes | Yes | 6 | 7 | 2 | 1 | R:R:L329 | R:R:W207 | 4.56 | 2 | Yes | Yes | 7 | 7 | 1 | 1 | R:R:V332 | R:R:W207 | 13.48 | 2 | No | Yes | 7 | 7 | 1 | 1 | L:L:?1 | R:R:W207 | 11.83 | 2 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:F209 | R:R:F328 | 3.22 | 2 | No | Yes | 8 | 6 | 2 | 2 | R:R:N338 | R:R:W295 | 9.04 | 2 | Yes | Yes | 9 | 8 | 2 | 2 | R:R:Q339 | R:R:W295 | 3.29 | 2 | Yes | Yes | 8 | 8 | 1 | 2 | R:R:L329 | R:R:R333 | 12.15 | 2 | Yes | Yes | 7 | 8 | 1 | 1 | L:L:?1 | R:R:L329 | 4.79 | 2 | Yes | Yes | 0 | 7 | 0 | 1 | L:L:?1 | R:R:V332 | 6.19 | 2 | Yes | No | 0 | 7 | 0 | 1 | L:L:?1 | R:R:R333 | 3.36 | 2 | Yes | Yes | 0 | 8 | 0 | 1 | L:L:?1 | R:R:S336 | 19.75 | 2 | Yes | No | 0 | 8 | 0 | 1 | R:R:N338 | R:R:Q339 | 7.92 | 2 | Yes | Yes | 9 | 8 | 2 | 1 | R:R:D342 | R:R:N338 | 8.08 | 2 | Yes | Yes | 9 | 9 | 2 | 2 | R:R:D342 | R:R:Q339 | 3.92 | 2 | Yes | Yes | 9 | 8 | 2 | 1 | L:L:?1 | R:R:Q339 | 8.29 | 2 | Yes | Yes | 0 | 8 | 0 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 15.00 | Average Number Of Links With An Hub | 7.00 | Average Interaction Strength | 7.98 | Average Nodes In Shell | 40.00 | Average Hubs In Shell | 18.00 | Average Links In Shell | 59.00 | Average Links Mediated by Hubs In Shell | 51.00 |
| ![](/psngpcr/ligands/P2E/P2E_6AK3_poly_L_L_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/P2E/P2E_6AK3_poly_L_L_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7CX2 | A | Lipid | Prostanoid | EP2 | Homo sapiens | PGE2 | - | Gs/Beta1/Gamma2 | 2.8 | 2021-05-05 | 10.1126/sciadv.abf1268 |
![](/psngpcr/ligands/P2E/P2E_7CX2_L_L_1.png)
A 2D representation of the interactions of P2E in 7CX2 colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:E23 | R:R:Y93 | 3.37 | 0 | No | Yes | 1 | 7 | 2 | 1 | R:R:E23 | R:R:R302 | 4.65 | 0 | No | Yes | 1 | 8 | 2 | 1 | R:R:I27 | R:R:R302 | 8.77 | 0 | No | Yes | 4 | 8 | 2 | 1 | L:L:?1 | R:R:S28 | 8.32 | 6 | Yes | No | 0 | 7 | 0 | 1 | R:R:M31 | R:R:R302 | 6.2 | 6 | No | Yes | 8 | 8 | 1 | 1 | L:L:?1 | R:R:M31 | 5.87 | 6 | Yes | No | 0 | 8 | 0 | 1 | R:R:F32 | R:R:V36 | 3.93 | 0 | No | No | 8 | 7 | 2 | 2 | R:R:F32 | R:R:S86 | 9.25 | 0 | No | Yes | 8 | 8 | 2 | 1 | R:R:T82 | R:R:V36 | 3.17 | 6 | No | No | 8 | 7 | 1 | 2 | R:R:D78 | R:R:T123 | 4.34 | 24 | Yes | No | 9 | 8 | 2 | 1 | R:R:D78 | R:R:S308 | 5.89 | 24 | Yes | No | 9 | 8 | 2 | 1 | R:R:S86 | R:R:T82 | 3.2 | 6 | Yes | No | 8 | 8 | 1 | 1 | L:L:?1 | R:R:T82 | 8.16 | 6 | Yes | No | 0 | 8 | 0 | 1 | R:R:F112 | R:R:I85 | 6.28 | 0 | No | No | 5 | 6 | 2 | 1 | R:R:A115 | R:R:I85 | 3.25 | 0 | No | No | 5 | 6 | 2 | 1 | L:L:?1 | R:R:I85 | 4.94 | 6 | Yes | No | 0 | 6 | 0 | 1 | L:L:?1 | R:R:S86 | 10.39 | 6 | Yes | Yes | 0 | 8 | 0 | 1 | R:R:T185 | R:R:V89 | 3.17 | 0 | No | No | 8 | 7 | 2 | 1 | L:L:?1 | R:R:V89 | 5.16 | 6 | Yes | No | 0 | 7 | 0 | 1 | R:R:T185 | R:R:Y93 | 6.24 | 0 | No | Yes | 8 | 7 | 2 | 1 | L:L:?1 | R:R:Y93 | 4.06 | 6 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:F188 | R:R:M116 | 3.73 | 16 | Yes | No | 8 | 7 | 2 | 1 | L:L:?1 | R:R:M116 | 8.81 | 6 | Yes | No | 0 | 7 | 0 | 1 | L:L:?1 | R:R:T123 | 5.1 | 6 | Yes | No | 0 | 8 | 0 | 1 | R:R:L207 | R:R:M124 | 4.24 | 0 | No | No | 7 | 7 | 2 | 1 | R:R:P183 | R:R:W186 | 8.11 | 6 | No | Yes | 8 | 7 | 2 | 2 | R:R:L298 | R:R:P183 | 6.57 | 6 | Yes | No | 6 | 8 | 1 | 2 | R:R:L298 | R:R:W186 | 6.83 | 6 | Yes | Yes | 6 | 7 | 1 | 2 | R:R:N307 | R:R:S277 | 4.47 | 0 | No | Yes | 9 | 9 | 1 | 2 | R:R:L298 | R:R:R302 | 8.5 | 6 | Yes | Yes | 6 | 8 | 1 | 1 | L:L:?1 | R:R:L298 | 7.67 | 6 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:Q299 | R:R:R302 | 8.18 | 0 | No | Yes | 4 | 8 | 2 | 1 | L:L:?1 | R:R:R302 | 6.73 | 6 | Yes | Yes | 0 | 8 | 0 | 1 | R:R:I309 | R:R:S305 | 3.1 | 0 | No | No | 9 | 8 | 2 | 1 | L:L:?1 | R:R:S305 | 11.43 | 6 | Yes | No | 0 | 8 | 0 | 1 | R:R:D311 | R:R:N307 | 6.73 | 0 | No | No | 9 | 9 | 2 | 1 | L:L:?1 | R:R:N307 | 6.65 | 6 | Yes | No | 0 | 9 | 0 | 1 | L:L:?1 | R:R:S308 | 6.24 | 6 | Yes | No | 0 | 8 | 0 | 1 | L:L:?1 | R:R:M124 | 2.94 | 6 | Yes | No | 0 | 7 | 0 | 1 | R:R:P87 | R:R:S86 | 1.78 | 0 | No | Yes | 7 | 8 | 2 | 1 | R:R:P25 | R:R:Y93 | 1.39 | 0 | No | Yes | 5 | 7 | 2 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 15.00 | Average Number Of Links With An Hub | 4.00 | Average Interaction Strength | 6.83 | Average Nodes In Shell | 34.00 | Average Hubs In Shell | 9.00 | Average Links In Shell | 41.00 | Average Links Mediated by Hubs In Shell | 33.00 |
| ![](/psngpcr/ligands/P2E/P2E_7CX2_L_L_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/P2E/P2E_7CX2_L_L_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7D7M | A | Lipid | Prostanoid | EP4 | Homo sapiens | Dinoprostone | - | Gs/Beta1/Gamma1 | 3.3 | 2020-11-18 | 10.1016/j.str.2020.11.007 |
![](/psngpcr/ligands/P2E/P2E_7D7M_L_L_1.png)
A 2D representation of the interactions of P2E in 7D7M colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:V21 | R:R:Y80 | 8.83 | 0 | No | Yes | 6 | 6 | 2 | 1 | R:R:I23 | R:R:P24 | 3.39 | 0 | No | No | 6 | 7 | 2 | 1 | R:R:I23 | R:R:R316 | 15.03 | 0 | No | Yes | 6 | 7 | 2 | 1 | R:R:P24 | R:R:T76 | 3.5 | 5 | No | No | 7 | 8 | 1 | 1 | L:L:?1 | R:R:P24 | 4.55 | 5 | Yes | No | 0 | 7 | 0 | 1 | R:R:M27 | R:R:R316 | 6.2 | 5 | Yes | Yes | 8 | 7 | 1 | 1 | R:R:M27 | R:R:S319 | 3.07 | 5 | Yes | No | 8 | 8 | 1 | 1 | R:R:M27 | R:R:V320 | 3.04 | 5 | Yes | No | 8 | 5 | 1 | 2 | L:L:?1 | R:R:M27 | 3.91 | 5 | Yes | Yes | 0 | 8 | 0 | 1 | R:R:F28 | R:R:S73 | 10.57 | 0 | No | Yes | 6 | 8 | 2 | 1 | R:R:G31 | R:R:I323 | 3.53 | 0 | No | No | 8 | 8 | 2 | 1 | R:R:D65 | R:R:P322 | 4.83 | 20 | No | No | 9 | 9 | 2 | 1 | L:L:?1 | R:R:T69 | 4.08 | 5 | Yes | No | 0 | 8 | 0 | 1 | R:R:I98 | R:R:V72 | 3.07 | 0 | Yes | No | 5 | 7 | 2 | 1 | L:L:?1 | R:R:V72 | 9.28 | 5 | Yes | No | 0 | 7 | 0 | 1 | R:R:I77 | R:R:S73 | 3.1 | 0 | No | Yes | 6 | 8 | 2 | 1 | L:L:?1 | R:R:S73 | 5.2 | 5 | Yes | Yes | 0 | 8 | 0 | 1 | L:L:?1 | R:R:T76 | 9.18 | 5 | Yes | No | 0 | 8 | 0 | 1 | R:R:T168 | R:R:T79 | 4.71 | 5 | Yes | No | 6 | 7 | 1 | 2 | R:R:T168 | R:R:Y80 | 13.73 | 5 | Yes | Yes | 6 | 6 | 1 | 1 | L:L:?1 | R:R:Y80 | 4.87 | 5 | Yes | Yes | 0 | 6 | 0 | 1 | L:L:?1 | R:R:S103 | 5.2 | 5 | Yes | No | 0 | 7 | 0 | 1 | R:R:P166 | R:R:T168 | 6.99 | 0 | No | Yes | 6 | 6 | 2 | 1 | L:L:?1 | R:R:T168 | 7.14 | 5 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:F171 | R:R:W169 | 9.02 | 0 | Yes | No | 6 | 5 | 2 | 1 | R:R:I315 | R:R:W169 | 11.74 | 0 | No | No | 6 | 5 | 2 | 1 | L:L:?1 | R:R:W169 | 6.31 | 5 | Yes | No | 0 | 5 | 0 | 1 | R:R:L312 | R:R:N309 | 4.12 | 5 | No | No | 6 | 2 | 1 | 2 | R:R:L312 | R:R:R316 | 8.5 | 5 | No | Yes | 6 | 7 | 1 | 1 | L:L:?1 | R:R:L312 | 6.71 | 5 | Yes | No | 0 | 6 | 0 | 1 | L:L:?1 | R:R:R316 | 3.36 | 5 | Yes | Yes | 0 | 7 | 0 | 1 | L:L:?1 | R:R:S319 | 8.32 | 5 | Yes | No | 0 | 8 | 0 | 1 | R:R:N321 | R:R:P322 | 6.52 | 0 | No | No | 9 | 9 | 2 | 1 | L:L:?1 | R:R:P322 | 3.41 | 5 | Yes | No | 0 | 9 | 0 | 1 | R:R:P20 | R:R:Y80 | 2.78 | 0 | No | Yes | 5 | 6 | 2 | 1 | R:R:P74 | R:R:S73 | 1.78 | 0 | No | Yes | 9 | 8 | 2 | 1 | L:L:?1 | R:R:I323 | 0.99 | 5 | Yes | No | 0 | 8 | 0 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 15.00 | Average Number Of Links With An Hub | 5.00 | Average Interaction Strength | 5.50 | Average Nodes In Shell | 32.00 | Average Hubs In Shell | 8.00 | Average Links In Shell | 37.00 | Average Links Mediated by Hubs In Shell | 30.00 |
| ![](/psngpcr/ligands/P2E/P2E_7D7M_L_L_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/P2E/P2E_7D7M_L_L_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8GCP | A | Lipid | Prostanoid | EP4 | Homo Sapiens | PGE2 | - | Gi1/Beta1/Gamma2 | 3.1 | 2024-01-03 | 10.1073/pnas.2216329120 |
![](/psngpcr/ligands/P2E/P2E_8GCP_L_L_1.png)
A 2D representation of the interactions of P2E in 8GCP colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:V21 | R:R:Y80 | 17.66 | 0 | No | Yes | 6 | 6 | 2 | 1 | R:R:I23 | R:R:P24 | 3.39 | 2 | Yes | No | 6 | 7 | 2 | 1 | R:R:I23 | R:R:M27 | 2.92 | 2 | Yes | No | 6 | 8 | 2 | 2 | R:R:I23 | R:R:R316 | 5.01 | 2 | Yes | Yes | 6 | 7 | 2 | 1 | R:R:P24 | R:R:T76 | 3.5 | 2 | No | No | 7 | 8 | 1 | 1 | L:L:?1 | R:R:P24 | 11.37 | 2 | Yes | No | 0 | 7 | 0 | 1 | R:R:M27 | R:R:R316 | 3.72 | 2 | No | Yes | 8 | 7 | 2 | 1 | R:R:F28 | R:R:S73 | 17.18 | 0 | Yes | No | 6 | 8 | 2 | 1 | R:R:D65 | R:R:P322 | 9.66 | 34 | No | No | 9 | 9 | 2 | 1 | R:R:S73 | R:R:T69 | 3.2 | 2 | No | No | 8 | 8 | 1 | 1 | L:L:?1 | R:R:T69 | 6.12 | 2 | Yes | No | 0 | 8 | 0 | 1 | R:R:I98 | R:R:V72 | 7.68 | 35 | Yes | No | 5 | 7 | 2 | 1 | L:L:?1 | R:R:V72 | 5.16 | 2 | Yes | No | 0 | 7 | 0 | 1 | L:L:?1 | R:R:S73 | 5.2 | 2 | Yes | No | 0 | 8 | 0 | 1 | R:R:T76 | R:R:Y80 | 2.5 | 2 | No | Yes | 8 | 6 | 1 | 1 | L:L:?1 | R:R:T76 | 9.18 | 2 | Yes | No | 0 | 8 | 0 | 1 | R:R:T168 | R:R:T79 | 3.14 | 2 | Yes | No | 6 | 7 | 1 | 2 | R:R:T168 | R:R:Y80 | 8.74 | 2 | Yes | Yes | 6 | 6 | 1 | 1 | L:L:?1 | R:R:Y80 | 4.87 | 2 | Yes | Yes | 0 | 6 | 0 | 1 | L:L:?1 | R:R:L99 | 5.75 | 2 | Yes | No | 0 | 8 | 0 | 1 | L:L:?1 | R:R:S103 | 6.24 | 2 | Yes | No | 0 | 7 | 0 | 1 | R:R:Q164 | R:R:W169 | 24.09 | 2 | No | Yes | 7 | 5 | 2 | 1 | R:R:F171 | R:R:Q164 | 3.51 | 2 | Yes | No | 6 | 7 | 2 | 2 | R:R:P166 | R:R:T168 | 3.5 | 2 | No | Yes | 6 | 6 | 2 | 1 | R:R:P166 | R:R:W169 | 6.76 | 2 | No | Yes | 6 | 5 | 2 | 1 | R:R:L312 | R:R:P166 | 6.57 | 2 | Yes | No | 6 | 6 | 1 | 2 | R:R:T168 | R:R:W169 | 3.64 | 2 | Yes | Yes | 6 | 5 | 1 | 1 | L:L:?1 | R:R:T168 | 4.08 | 2 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:F171 | R:R:W169 | 3.01 | 2 | Yes | Yes | 6 | 5 | 2 | 1 | R:R:I315 | R:R:W169 | 10.57 | 2 | No | Yes | 6 | 5 | 1 | 1 | L:L:?1 | R:R:W169 | 4.73 | 2 | Yes | Yes | 0 | 5 | 0 | 1 | R:R:L312 | R:R:N309 | 5.49 | 2 | Yes | No | 6 | 2 | 1 | 2 | R:R:L312 | R:R:R316 | 13.36 | 2 | Yes | Yes | 6 | 7 | 1 | 1 | L:L:?1 | R:R:L312 | 8.62 | 2 | Yes | Yes | 0 | 6 | 0 | 1 | L:L:?1 | R:R:I315 | 2.96 | 2 | Yes | No | 0 | 6 | 0 | 1 | L:L:?1 | R:R:R316 | 8.41 | 2 | Yes | Yes | 0 | 7 | 0 | 1 | L:L:?1 | R:R:S319 | 17.67 | 2 | Yes | No | 0 | 8 | 0 | 1 | L:L:?1 | R:R:P322 | 3.41 | 2 | Yes | No | 0 | 9 | 0 | 1 | R:R:N321 | R:R:P322 | 1.63 | 0 | No | No | 9 | 9 | 2 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 15.00 | Average Number Of Links With An Hub | 5.00 | Average Interaction Strength | 6.92 | Average Nodes In Shell | 28.00 | Average Hubs In Shell | 10.00 | Average Links In Shell | 39.00 | Average Links Mediated by Hubs In Shell | 35.00 |
| ![](/psngpcr/ligands/P2E/P2E_8GCP_L_L_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/P2E/P2E_8GCP_L_L_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8GDB | A | Lipid | Prostanoid | EP4 | Homo Sapiens | PGE2 | - | Gs/Beta1/Gamma2 | 3.1 | 2024-01-03 | 10.1073/pnas.2216329120 |
![](/psngpcr/ligands/P2E/P2E_8GDB_L_L_1.png)
A 2D representation of the interactions of P2E in 8GDB colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:I23 | R:R:P24 | 3.39 | 3 | No | No | 6 | 7 | 2 | 1 | R:R:I23 | R:R:M27 | 2.92 | 3 | No | No | 6 | 8 | 2 | 1 | R:R:I23 | R:R:R316 | 10.02 | 3 | No | Yes | 6 | 7 | 2 | 1 | R:R:P24 | R:R:R316 | 4.32 | 3 | No | Yes | 7 | 7 | 1 | 1 | L:L:?1 | R:R:P24 | 5.68 | 3 | Yes | No | 0 | 7 | 0 | 1 | L:L:?1 | R:R:M27 | 5.87 | 3 | Yes | No | 0 | 8 | 0 | 1 | R:R:F28 | R:R:S73 | 9.25 | 0 | No | Yes | 6 | 8 | 2 | 1 | R:R:D65 | R:R:P322 | 8.05 | 15 | Yes | No | 9 | 9 | 2 | 1 | R:R:S73 | R:R:T69 | 4.8 | 3 | Yes | No | 8 | 8 | 1 | 1 | L:L:?1 | R:R:T69 | 4.08 | 3 | Yes | No | 0 | 8 | 0 | 1 | R:R:I98 | R:R:V72 | 6.14 | 28 | Yes | No | 5 | 7 | 2 | 1 | L:L:?1 | R:R:V72 | 5.16 | 3 | Yes | No | 0 | 7 | 0 | 1 | R:R:P74 | R:R:S73 | 3.56 | 0 | No | Yes | 9 | 8 | 2 | 1 | L:L:?1 | R:R:S73 | 7.28 | 3 | Yes | Yes | 0 | 8 | 0 | 1 | L:L:?1 | R:R:T76 | 6.12 | 3 | Yes | No | 0 | 8 | 0 | 1 | L:L:?1 | R:R:Y80 | 6.49 | 3 | Yes | No | 0 | 6 | 0 | 1 | R:R:F171 | R:R:L99 | 4.87 | 0 | Yes | No | 6 | 8 | 2 | 1 | L:L:?1 | R:R:L99 | 2.87 | 3 | Yes | No | 0 | 8 | 0 | 1 | R:R:F171 | R:R:W169 | 3.01 | 0 | Yes | Yes | 6 | 5 | 2 | 2 | R:R:L312 | R:R:W169 | 3.42 | 3 | No | Yes | 6 | 5 | 1 | 2 | R:R:I315 | R:R:W169 | 16.44 | 0 | No | Yes | 6 | 5 | 1 | 2 | R:R:L312 | R:R:R316 | 8.5 | 3 | No | Yes | 6 | 7 | 1 | 1 | L:L:?1 | R:R:L312 | 4.79 | 3 | Yes | No | 0 | 6 | 0 | 1 | L:L:?1 | R:R:I315 | 2.96 | 3 | Yes | No | 0 | 6 | 0 | 1 | L:L:?1 | R:R:R316 | 10.09 | 3 | Yes | Yes | 0 | 7 | 0 | 1 | L:L:?1 | R:R:S319 | 10.39 | 3 | Yes | No | 0 | 8 | 0 | 1 | L:L:?1 | R:R:P322 | 4.55 | 3 | Yes | No | 0 | 9 | 0 | 1 | R:R:V21 | R:R:Y80 | 2.52 | 0 | No | No | 6 | 6 | 2 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 13.00 | Average Number Of Links With An Hub | 2.00 | Average Interaction Strength | 5.87 | Average Nodes In Shell | 22.00 | Average Hubs In Shell | 7.00 | Average Links In Shell | 28.00 | Average Links Mediated by Hubs In Shell | 25.00 |
| ![](/psngpcr/ligands/P2E/P2E_8GDB_L_L_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/P2E/P2E_8GDB_L_L_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8GDC | A | Lipid | Prostanoid | EP3 | Homo Sapiens | PGE2 | - | Gi1/Beta1/Gamma2 | 3.5 | 2024-01-03 | 10.1073/pnas.2216329120 |
![](/psngpcr/ligands/P2E/P2E_8GDC_L_L_1.png)
A 2D representation of the interactions of P2E in 8GDC colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:P55 | R:R:V110 | 3.53 | 2 | Yes | Yes | 7 | 8 | 1 | 2 | R:R:I111 | R:R:P55 | 5.08 | 0 | No | Yes | 7 | 7 | 2 | 1 | R:R:P55 | R:R:Y114 | 4.17 | 2 | Yes | Yes | 7 | 8 | 1 | 2 | L:L:?1 | R:R:P55 | 6.82 | 2 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:M58 | R:R:T57 | 3.01 | 2 | No | No | 8 | 4 | 1 | 2 | R:R:M58 | R:R:R333 | 2.48 | 2 | No | No | 8 | 8 | 1 | 1 | L:L:?1 | R:R:M58 | 11.74 | 2 | Yes | No | 0 | 8 | 0 | 1 | R:R:L59 | R:R:T107 | 10.32 | 0 | No | Yes | 7 | 8 | 2 | 1 | L:L:?1 | R:R:Q103 | 20.27 | 2 | Yes | No | 0 | 8 | 0 | 1 | R:R:F133 | R:R:T106 | 7.78 | 2 | Yes | No | 6 | 6 | 2 | 1 | R:R:T106 | R:R:T136 | 4.71 | 2 | No | Yes | 6 | 5 | 1 | 2 | L:L:?1 | R:R:T106 | 3.06 | 2 | Yes | No | 0 | 6 | 0 | 1 | R:R:P108 | R:R:T107 | 3.5 | 0 | No | Yes | 8 | 8 | 2 | 1 | R:R:I111 | R:R:T107 | 3.04 | 0 | No | Yes | 7 | 8 | 2 | 1 | L:L:?1 | R:R:T107 | 7.14 | 2 | Yes | Yes | 0 | 8 | 0 | 1 | R:R:V110 | R:R:Y114 | 5.05 | 2 | Yes | Yes | 8 | 8 | 2 | 2 | R:R:F133 | R:R:V110 | 2.62 | 2 | Yes | Yes | 6 | 8 | 2 | 2 | R:R:T206 | R:R:V110 | 6.35 | 2 | Yes | Yes | 8 | 8 | 2 | 2 | R:R:T206 | R:R:Y114 | 11.24 | 2 | Yes | Yes | 8 | 8 | 2 | 2 | R:R:F133 | R:R:T136 | 2.59 | 2 | Yes | Yes | 6 | 5 | 2 | 2 | R:R:F133 | R:R:M137 | 2.49 | 2 | Yes | Yes | 6 | 7 | 2 | 1 | R:R:F209 | R:R:M137 | 8.71 | 2 | No | Yes | 8 | 7 | 1 | 1 | R:R:M137 | R:R:V332 | 3.04 | 2 | Yes | No | 7 | 7 | 1 | 2 | L:L:?1 | R:R:M137 | 13.7 | 2 | Yes | Yes | 0 | 7 | 0 | 1 | L:L:?1 | R:R:G141 | 2.37 | 2 | Yes | No | 0 | 7 | 0 | 1 | R:R:L145 | R:R:W295 | 14.81 | 0 | No | Yes | 8 | 8 | 2 | 1 | R:R:Q202 | R:R:W207 | 15.33 | 0 | No | Yes | 8 | 7 | 2 | 1 | R:R:P204 | R:R:W207 | 12.16 | 2 | Yes | Yes | 7 | 7 | 2 | 1 | R:R:L329 | R:R:P204 | 9.85 | 2 | Yes | Yes | 7 | 7 | 2 | 2 | R:R:T206 | R:R:W207 | 2.43 | 2 | Yes | Yes | 8 | 7 | 2 | 1 | R:R:F209 | R:R:W207 | 8.02 | 2 | No | Yes | 8 | 7 | 1 | 1 | R:R:F328 | R:R:W207 | 7.02 | 0 | No | Yes | 6 | 7 | 2 | 1 | R:R:V332 | R:R:W207 | 3.68 | 0 | No | Yes | 7 | 7 | 2 | 1 | L:L:?1 | R:R:W207 | 6.31 | 2 | Yes | Yes | 0 | 7 | 0 | 1 | L:L:?1 | R:R:F209 | 2.53 | 2 | Yes | No | 0 | 8 | 0 | 1 | R:R:L299 | R:R:W295 | 4.56 | 35 | Yes | Yes | 8 | 8 | 2 | 1 | R:R:A335 | R:R:W295 | 5.19 | 0 | No | Yes | 8 | 8 | 2 | 1 | R:R:N338 | R:R:W295 | 9.04 | 0 | Yes | Yes | 9 | 8 | 2 | 1 | L:L:?1 | R:R:W295 | 3.15 | 2 | Yes | Yes | 0 | 8 | 0 | 1 | R:R:L329 | R:R:R333 | 7.29 | 2 | Yes | No | 7 | 8 | 2 | 1 | L:L:?1 | R:R:R333 | 10.09 | 2 | Yes | No | 0 | 8 | 0 | 1 | L:L:?1 | R:R:S336 | 12.47 | 2 | Yes | No | 0 | 8 | 0 | 1 | R:R:F54 | R:R:P55 | 1.44 | 0 | No | Yes | 4 | 7 | 2 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 12.00 | Average Number Of Links With An Hub | 5.00 | Average Interaction Strength | 8.30 | Average Nodes In Shell | 32.00 | Average Hubs In Shell | 15.00 | Average Links In Shell | 43.00 | Average Links Mediated by Hubs In Shell | 41.00 |
| ![](/psngpcr/ligands/P2E/P2E_8GDC_L_L_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/P2E/P2E_8GDC_L_L_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|