CodeP2E
NameDinoprostone
SynonymsDinoprostona
Identifier
FormulaC20 H32 O5
Molecular Weight352.465
SMILES
PubChem5280360
Formal Charge0
Total Atoms57
Total Chiral Atoms4
Total Bonds57
Total Aromatic Bonds0
Networks14
 missing image

This ligand is also present in the following 14 networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
6AK3 A Lipid Prostanoid EP3 Homo Sapiens Dinoprostone IPGE2 - - 2.9 2018-12-05 doi.org/10.1038/s41589-018-0171-8

A 2D representation of the interactions of P2E in 6AK3
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:P55 3.57 1 Yes No 0 7 0 1
L:L:?1 R:R:M58 9.22 1 Yes No 0 8 0 1
L:L:?1 R:R:T106 5.34 1 Yes No 0 6 0 1
L:L:?1 R:R:T107 12.82 1 Yes No 0 8 0 1
L:L:?1 R:R:V110 6.48 1 Yes No 0 8 0 1
L:L:?1 R:R:Y114 7.65 1 Yes Yes 0 8 0 1
L:L:?1 R:R:M137 10.24 1 Yes No 0 7 0 1
L:L:?1 R:R:T206 7.48 1 Yes Yes 0 8 0 1
L:L:?1 R:R:W207 11.55 1 Yes Yes 0 7 0 1
L:L:?1 R:R:W295 3.3 1 Yes Yes 0 8 0 1
L:L:?1 R:R:L329 6.02 1 Yes Yes 0 7 0 1
L:L:?1 R:R:V332 6.48 1 Yes No 0 7 0 1
L:L:?1 R:R:R333 5.28 1 Yes Yes 0 8 0 1
L:L:?1 R:R:S336 20.67 1 Yes No 0 8 0 1
L:L:?1 R:R:Q339 9.64 1 Yes Yes 0 8 0 1
R:R:V50 R:R:Y114 3.79 1 Yes Yes 4 8 2 1
R:R:V50 R:R:W203 3.68 1 Yes Yes 4 4 2 2
R:R:P204 R:R:V50 8.84 1 No Yes 7 4 2 2
R:R:V52 R:R:Y114 10.09 0 No Yes 5 8 2 1
R:R:F54 R:R:R333 17.1 0 No Yes 4 8 2 1
R:R:P55 R:R:V110 3.53 1 No No 7 8 1 1
R:R:M58 R:R:R333 3.72 1 No Yes 8 8 1 1
R:R:I340 R:R:M58 4.37 0 No No 9 8 2 1
R:R:L59 R:R:T107 13.27 0 No No 7 8 2 1
R:R:D99 R:R:S144 4.42 1 Yes No 9 8 2 2
R:R:D99 R:R:Q339 10.44 1 Yes Yes 9 8 2 1
R:R:D342 R:R:D99 7.98 1 Yes Yes 9 9 2 2
R:R:F133 R:R:T106 6.49 3 Yes No 6 6 2 1
R:R:T106 R:R:T136 3.14 0 No No 6 5 1 2
R:R:P108 R:R:T107 3.5 0 No No 8 8 2 1
R:R:T206 R:R:V110 3.17 1 Yes No 8 8 1 1
R:R:T206 R:R:V113 4.76 1 Yes No 8 7 1 2
R:R:T206 R:R:Y114 14.98 1 Yes Yes 8 8 1 1
R:R:F133 R:R:M137 4.98 3 Yes No 6 7 2 1
R:R:Q339 R:R:S144 8.66 1 Yes No 8 8 1 2
R:R:D342 R:R:S144 5.89 1 Yes No 9 8 2 2
R:R:L145 R:R:W295 20.5 0 No Yes 8 8 2 1
R:R:Q202 R:R:W207 16.43 1 No Yes 8 7 2 1
R:R:F209 R:R:Q202 3.51 1 No No 8 8 2 2
R:R:F328 R:R:Q202 3.51 1 Yes No 6 8 2 2
R:R:P204 R:R:W203 20.27 1 No Yes 7 4 2 2
R:R:L329 R:R:W203 4.56 1 Yes Yes 7 4 1 2
R:R:P204 R:R:T206 3.5 1 No Yes 7 8 2 1
R:R:T206 R:R:W207 3.64 1 Yes Yes 8 7 1 1
R:R:F209 R:R:W207 5.01 1 No Yes 8 7 2 1
R:R:F328 R:R:W207 5.01 1 Yes Yes 6 7 2 1
R:R:L329 R:R:W207 4.56 1 Yes Yes 7 7 1 1
R:R:V332 R:R:W207 13.48 1 No Yes 7 7 1 1
R:R:F209 R:R:F328 3.22 1 No Yes 8 6 2 2
R:R:L299 R:R:W295 3.42 0 No Yes 8 8 2 1
R:R:A335 R:R:W295 7.78 0 No Yes 8 8 2 1
R:R:N338 R:R:W295 9.04 1 Yes Yes 9 8 2 1
R:R:Q339 R:R:W295 4.38 1 Yes Yes 8 8 1 1
R:R:L329 R:R:R333 12.15 1 Yes Yes 7 8 1 1
R:R:N338 R:R:Q339 7.92 1 Yes Yes 9 8 2 1
R:R:D342 R:R:N338 6.73 1 Yes Yes 9 9 2 2
R:R:D342 R:R:Q339 3.92 1 Yes Yes 9 8 2 1
R:R:G141 R:R:W295 2.81 0 No Yes 7 8 2 1
StatisticsValue
Average Number Of Links15.00
Average Number Of Links With An Hub7.00
Average Interaction Strength8.38
Average Nodes In Shell38.00
Average Hubs In Shell15.00
Average Links In Shell58.00
Average Links Mediated by Hubs In Shell52.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7CX2 A Lipid Prostanoid EP2 Homo Sapiens PGE2 - Gs/Beta1/Gamma2 2.8 2021-05-05 doi.org/10.1126/sciadv.abf1268

A 2D representation of the interactions of P2E in 7CX2
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:E23 R:R:Y93 3.37 0 No Yes 1 7 2 1
R:R:E23 R:R:R302 4.65 0 No Yes 1 8 2 1
R:R:I27 R:R:R302 8.77 0 No Yes 4 8 2 1
L:L:?1 R:R:S28 8.7 6 Yes No 0 7 0 1
R:R:M31 R:R:R302 6.2 6 No Yes 8 8 1 1
L:L:?1 R:R:M31 6.15 6 Yes No 0 8 0 1
R:R:F32 R:R:V36 3.93 0 No No 8 7 2 2
R:R:F32 R:R:S86 9.25 0 No Yes 8 8 2 1
R:R:T82 R:R:V36 3.17 6 No No 8 7 1 2
R:R:D78 R:R:T123 4.34 24 Yes No 9 8 2 1
R:R:D78 R:R:S308 5.89 24 Yes No 9 8 2 1
R:R:S86 R:R:T82 3.2 6 Yes No 8 8 1 1
L:L:?1 R:R:T82 8.54 6 Yes No 0 8 0 1
R:R:F112 R:R:I85 6.28 0 No No 5 6 2 1
R:R:A115 R:R:I85 3.25 0 No No 5 6 2 1
L:L:?1 R:R:I85 5.17 6 Yes No 0 6 0 1
L:L:?1 R:R:S86 10.88 6 Yes Yes 0 8 0 1
R:R:T185 R:R:V89 3.17 6 Yes No 8 7 1 1
L:L:?1 R:R:V89 5.4 6 Yes No 0 7 0 1
R:R:T185 R:R:Y93 6.24 6 Yes Yes 8 7 1 1
L:L:?1 R:R:Y93 4.25 6 Yes Yes 0 7 0 1
R:R:F188 R:R:M116 3.73 16 Yes No 8 7 2 1
L:L:?1 R:R:M116 9.22 6 Yes No 0 7 0 1
L:L:?1 R:R:T123 5.34 6 Yes No 0 8 0 1
R:R:L207 R:R:M124 4.24 0 No No 7 7 2 1
R:R:P183 R:R:W186 8.11 6 No Yes 8 7 2 2
R:R:L298 R:R:P183 6.57 6 Yes No 6 8 1 2
L:L:?1 R:R:T185 3.2 6 Yes Yes 0 8 0 1
R:R:L298 R:R:W186 6.83 6 Yes Yes 6 7 1 2
R:R:N307 R:R:S277 4.47 0 No Yes 9 9 1 2
R:R:L298 R:R:R302 8.5 6 Yes Yes 6 8 1 1
L:L:?1 R:R:L298 8.02 6 Yes Yes 0 6 0 1
R:R:Q299 R:R:R302 8.18 0 No Yes 4 8 2 1
L:L:?1 R:R:R302 7.04 6 Yes Yes 0 8 0 1
R:R:I309 R:R:S305 3.1 0 No No 9 8 2 1
L:L:?1 R:R:S305 11.97 6 Yes No 0 8 0 1
R:R:D311 R:R:N307 6.73 0 No No 9 9 2 1
L:L:?1 R:R:N307 6.96 6 Yes No 0 9 0 1
L:L:?1 R:R:S308 6.53 6 Yes No 0 8 0 1
L:L:?1 R:R:M124 3.07 6 Yes No 0 7 0 1
R:R:P87 R:R:S86 1.78 0 No Yes 7 8 2 1
R:R:S92 R:R:T185 1.6 0 No Yes 5 8 2 1
R:R:P25 R:R:Y93 1.39 0 No Yes 5 7 2 1
StatisticsValue
Average Number Of Links16.00
Average Number Of Links With An Hub5.00
Average Interaction Strength6.90
Average Nodes In Shell35.00
Average Hubs In Shell10.00
Average Links In Shell43.00
Average Links Mediated by Hubs In Shell36.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7D7M A Lipid Prostanoid EP4 Homo Sapiens Dinoprostone - Gs/Beta1/Gamma1 3.3 2020-11-18 doi.org/10.1016/j.str.2020.11.007

A 2D representation of the interactions of P2E in 7D7M
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:P24 4.76 2 Yes No 0 7 0 1
L:L:?1 R:R:M27 4.1 2 Yes Yes 0 8 0 1
L:L:?1 R:R:T69 4.27 2 Yes No 0 8 0 1
L:L:?1 R:R:V72 9.72 2 Yes No 0 7 0 1
L:L:?1 R:R:S73 5.44 2 Yes Yes 0 8 0 1
L:L:?1 R:R:T76 9.61 2 Yes No 0 8 0 1
L:L:?1 R:R:Y80 5.1 2 Yes Yes 0 6 0 1
L:L:?1 R:R:S103 5.44 2 Yes No 0 7 0 1
L:L:?1 R:R:T168 7.48 2 Yes Yes 0 6 0 1
L:L:?1 R:R:W169 6.6 2 Yes Yes 0 5 0 1
L:L:?1 R:R:L312 7.02 2 Yes No 0 6 0 1
L:L:?1 R:R:I315 3.1 2 Yes No 0 6 0 1
L:L:?1 R:R:R316 3.52 2 Yes Yes 0 7 0 1
L:L:?1 R:R:S319 8.7 2 Yes No 0 8 0 1
L:L:?1 R:R:P322 3.57 2 Yes No 0 9 0 1
R:R:V21 R:R:Y80 8.83 0 No Yes 6 6 2 1
R:R:I23 R:R:P24 3.39 0 No No 6 7 2 1
R:R:I23 R:R:R316 15.03 0 No Yes 6 7 2 1
R:R:P24 R:R:T76 3.5 2 No No 7 8 1 1
R:R:M27 R:R:R316 6.2 2 Yes Yes 8 7 1 1
R:R:M27 R:R:S319 3.07 2 Yes No 8 8 1 1
R:R:M27 R:R:V320 3.04 2 Yes No 8 5 1 2
R:R:F28 R:R:S73 10.57 0 No Yes 6 8 2 1
R:R:G31 R:R:I323 3.53 0 No No 8 8 2 1
R:R:D65 R:R:P322 4.83 24 No No 9 9 2 1
R:R:I98 R:R:V72 3.07 0 Yes No 5 7 2 1
R:R:I77 R:R:S73 3.1 0 No Yes 6 8 2 1
R:R:T168 R:R:T79 4.71 2 Yes No 6 7 1 2
R:R:T168 R:R:Y80 13.73 2 Yes Yes 6 6 1 1
R:R:Q164 R:R:W169 3.29 2 Yes Yes 7 5 2 1
R:R:N309 R:R:Q164 5.28 2 Yes Yes 2 7 2 2
R:R:P166 R:R:T168 6.99 0 No Yes 6 6 2 1
R:R:F171 R:R:W169 9.02 0 Yes Yes 6 5 2 1
R:R:I315 R:R:W169 11.74 2 No Yes 6 5 1 1
R:R:L312 R:R:N309 4.12 2 No Yes 6 2 1 2
R:R:L312 R:R:R316 8.5 2 No Yes 6 7 1 1
R:R:N321 R:R:P322 6.52 0 No No 9 9 2 1
R:R:I315 R:R:L288 2.85 2 No No 6 7 1 2
R:R:P20 R:R:Y80 2.78 0 No Yes 5 6 2 1
R:R:P74 R:R:S73 1.78 0 No Yes 9 8 2 1
L:L:?1 R:R:I323 1.03 2 Yes No 0 8 0 1
StatisticsValue
Average Number Of Links16.00
Average Number Of Links With An Hub6.00
Average Interaction Strength5.59
Average Nodes In Shell34.00
Average Hubs In Shell11.00
Average Links In Shell41.00
Average Links Mediated by Hubs In Shell35.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8GCP A Lipid Prostanoid EP4 Homo Sapiens PGE2 - Gi1/Beta1/Gamma2 3.1 2024-01-03 doi.org/10.1073/pnas.2216329120

A 2D representation of the interactions of P2E in 8GCP
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:P24 12.28 2 Yes No 0 7 0 1
L:L:?1 R:R:T69 6.61 2 Yes No 0 8 0 1
L:L:?1 R:R:V72 5.57 2 Yes No 0 7 0 1
L:L:?1 R:R:S73 5.61 2 Yes Yes 0 8 0 1
L:L:?1 R:R:T76 9.92 2 Yes No 0 8 0 1
L:L:?1 R:R:Y80 5.26 2 Yes Yes 0 6 0 1
L:L:?1 R:R:L99 6.21 2 Yes No 0 8 0 1
L:L:?1 R:R:S103 6.74 2 Yes No 0 7 0 1
L:L:?1 R:R:T168 4.41 2 Yes Yes 0 6 0 1
L:L:?1 R:R:W169 5.11 2 Yes Yes 0 5 0 1
L:L:?1 R:R:L312 9.32 2 Yes Yes 0 6 0 1
L:L:?1 R:R:I315 3.2 2 Yes No 0 6 0 1
L:L:?1 R:R:R316 9.08 2 Yes Yes 0 7 0 1
L:L:?1 R:R:S319 19.09 2 Yes No 0 8 0 1
L:L:?1 R:R:P322 3.68 2 Yes No 0 9 0 1
R:R:V21 R:R:Y80 17.66 0 No Yes 6 6 2 1
R:R:I23 R:R:P24 3.39 2 No No 6 7 2 1
R:R:I23 R:R:M27 2.92 2 No No 6 8 2 2
R:R:I23 R:R:R316 5.01 2 No Yes 6 7 2 1
R:R:P24 R:R:T76 3.5 2 No No 7 8 1 1
R:R:M27 R:R:R316 3.72 2 No Yes 8 7 2 1
R:R:F28 R:R:S73 15.85 0 Yes Yes 6 8 2 1
R:R:D65 R:R:P322 11.27 0 No No 9 9 2 1
R:R:S73 R:R:T69 3.2 2 Yes No 8 8 1 1
R:R:I98 R:R:V72 9.22 0 Yes No 5 7 2 1
R:R:T76 R:R:Y80 2.5 2 No Yes 8 6 1 1
R:R:T168 R:R:T79 3.14 2 Yes No 6 7 1 2
R:R:T168 R:R:Y80 8.74 2 Yes Yes 6 6 1 1
R:R:Q164 R:R:W169 24.09 2 No Yes 7 5 2 1
R:R:F171 R:R:Q164 3.51 2 Yes No 6 7 2 2
R:R:P166 R:R:T168 3.5 2 No Yes 6 6 2 1
R:R:P166 R:R:W169 6.76 2 No Yes 6 5 2 1
R:R:L312 R:R:P166 6.57 2 Yes No 6 6 1 2
R:R:T168 R:R:W169 3.64 2 Yes Yes 6 5 1 1
R:R:F171 R:R:W169 3.01 2 Yes Yes 6 5 2 1
R:R:L312 R:R:W169 2.28 2 Yes Yes 6 5 1 1
R:R:I315 R:R:W169 10.57 2 No Yes 6 5 1 1
R:R:L312 R:R:N309 5.49 2 Yes Yes 6 2 1 2
R:R:L312 R:R:R316 13.36 2 Yes Yes 6 7 1 1
R:R:P74 R:R:S73 1.78 0 No Yes 9 8 2 1
R:R:N321 R:R:P322 1.63 0 No No 9 9 2 1
R:R:R316 R:R:V306 1.31 2 Yes No 7 3 1 2
StatisticsValue
Average Number Of Links15.00
Average Number Of Links With An Hub6.00
Average Interaction Strength7.47
Average Nodes In Shell30.00
Average Hubs In Shell11.00
Average Links In Shell42.00
Average Links Mediated by Hubs In Shell37.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8GDB A Lipid Prostanoid EP4 Homo Sapiens PGE2 - Gs/Beta1/Gamma2 3.1 2024-01-03 doi.org/10.1073/pnas.2216329120

A 2D representation of the interactions of P2E in 8GDB
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:P24 6.14 7 Yes No 0 7 0 1
L:L:?1 R:R:M27 6.34 7 Yes No 0 8 0 1
L:L:?1 R:R:T69 4.41 7 Yes No 0 8 0 1
L:L:?1 R:R:V72 5.57 7 Yes No 0 7 0 1
L:L:?1 R:R:S73 7.86 7 Yes Yes 0 8 0 1
L:L:?1 R:R:T76 6.61 7 Yes No 0 8 0 1
L:L:?1 R:R:Y80 7.01 7 Yes No 0 6 0 1
L:L:?1 R:R:L99 3.11 7 Yes No 0 8 0 1
L:L:?1 R:R:L312 5.18 7 Yes No 0 6 0 1
L:L:?1 R:R:I315 3.2 7 Yes No 0 6 0 1
L:L:?1 R:R:R316 10.9 7 Yes Yes 0 7 0 1
L:L:?1 R:R:S319 11.23 7 Yes No 0 8 0 1
L:L:?1 R:R:P322 4.91 7 Yes No 0 9 0 1
R:R:I23 R:R:P24 3.39 7 No No 6 7 2 1
R:R:I23 R:R:M27 2.92 7 No No 6 8 2 1
R:R:I23 R:R:R316 10.02 7 No Yes 6 7 2 1
R:R:P24 R:R:R316 4.32 7 No Yes 7 7 1 1
R:R:F28 R:R:S73 11.89 0 No Yes 6 8 2 1
R:R:D65 R:R:P322 8.05 17 Yes No 9 9 2 1
R:R:S73 R:R:T69 4.8 7 Yes No 8 8 1 1
R:R:I98 R:R:V72 6.14 27 Yes No 5 7 2 1
R:R:F171 R:R:L99 4.87 0 Yes No 6 8 2 1
R:R:F171 R:R:W169 3.01 0 Yes Yes 6 5 2 2
R:R:L312 R:R:W169 3.42 7 No Yes 6 5 1 2
R:R:I315 R:R:W169 16.44 0 No Yes 6 5 1 2
R:R:L312 R:R:R316 8.5 7 No Yes 6 7 1 1
R:R:V21 R:R:Y80 2.52 0 No No 6 6 2 1
R:R:P74 R:R:S73 1.78 0 No Yes 9 8 2 1
StatisticsValue
Average Number Of Links13.00
Average Number Of Links With An Hub2.00
Average Interaction Strength6.34
Average Nodes In Shell22.00
Average Hubs In Shell7.00
Average Links In Shell28.00
Average Links Mediated by Hubs In Shell25.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8GDC A Lipid Prostanoid EP3 Homo Sapiens PGE2 - Gi1/Beta1/Gamma2 3.5 2024-01-03 doi.org/10.1073/pnas.2216329120

A 2D representation of the interactions of P2E in 8GDC
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:P55 7.37 1 Yes Yes 0 7 0 1
L:L:?1 R:R:M58 12.69 1 Yes Yes 0 8 0 1
L:L:?1 R:R:Q103 21.9 1 Yes No 0 8 0 1
L:L:?1 R:R:T106 3.31 1 Yes No 0 6 0 1
L:L:?1 R:R:T107 7.72 1 Yes Yes 0 8 0 1
L:L:?1 R:R:M137 14.8 1 Yes Yes 0 7 0 1
L:L:?1 R:R:G141 2.56 1 Yes No 0 7 0 1
L:L:?1 R:R:W207 6.81 1 Yes Yes 0 7 0 1
L:L:?1 R:R:F209 2.73 1 Yes No 0 8 0 1
L:L:?1 R:R:W295 3.41 1 Yes Yes 0 8 0 1
L:L:?1 R:R:R333 10.9 1 Yes Yes 0 8 0 1
L:L:?1 R:R:S336 17.96 1 Yes No 0 8 0 1
R:R:F54 R:R:M58 3.73 1 No Yes 4 8 2 1
R:R:F54 R:R:R333 3.21 1 No Yes 4 8 2 1
R:R:P55 R:R:V110 3.53 1 Yes Yes 7 8 1 2
R:R:I111 R:R:P55 3.39 0 Yes Yes 7 7 2 1
R:R:P55 R:R:Y114 4.17 1 Yes Yes 7 8 1 2
R:R:M58 R:R:R333 2.48 1 Yes Yes 8 8 1 1
R:R:I340 R:R:M58 4.37 0 Yes Yes 9 8 2 1
R:R:L59 R:R:T107 8.84 0 No Yes 7 8 2 1
R:R:Q103 R:R:S336 2.89 1 No No 8 8 1 1
R:R:F133 R:R:T106 7.78 1 Yes No 6 6 2 1
R:R:T106 R:R:T136 4.71 1 No Yes 6 5 1 2
R:R:P108 R:R:T107 3.5 0 No Yes 8 8 2 1
R:R:I111 R:R:T107 3.04 0 Yes Yes 7 8 2 1
R:R:V110 R:R:Y114 5.05 1 Yes Yes 8 8 2 2
R:R:F133 R:R:V110 2.62 1 Yes Yes 6 8 2 2
R:R:T206 R:R:V110 6.35 1 Yes Yes 8 8 2 2
R:R:T206 R:R:Y114 11.24 1 Yes Yes 8 8 2 2
R:R:F133 R:R:T136 2.59 1 Yes Yes 6 5 2 2
R:R:F133 R:R:M137 2.49 1 Yes Yes 6 7 2 1
R:R:F209 R:R:M137 8.71 1 No Yes 8 7 1 1
R:R:M137 R:R:V332 3.04 1 Yes No 7 7 1 2
R:R:L145 R:R:W295 14.81 0 No Yes 8 8 2 1
R:R:Q202 R:R:W207 15.33 0 No Yes 8 7 2 1
R:R:P204 R:R:W207 12.16 1 Yes Yes 7 7 2 1
R:R:L329 R:R:P204 6.57 1 Yes Yes 7 7 2 2
R:R:T206 R:R:W207 2.43 1 Yes Yes 8 7 2 1
R:R:F209 R:R:W207 8.02 1 No Yes 8 7 1 1
R:R:F328 R:R:W207 7.02 0 No Yes 6 7 2 1
R:R:V332 R:R:W207 3.68 0 No Yes 7 7 2 1
R:R:L298 R:R:W295 12.53 1 Yes Yes 7 8 2 1
R:R:L299 R:R:W295 4.56 1 Yes Yes 8 8 2 1
R:R:A335 R:R:W295 5.19 1 No Yes 8 8 2 1
R:R:N338 R:R:W295 9.04 0 Yes Yes 9 8 2 1
R:R:L298 R:R:L299 6.92 1 Yes Yes 7 8 2 2
R:R:A335 R:R:L298 3.15 1 No Yes 8 7 2 2
R:R:L329 R:R:R333 13.36 1 Yes Yes 7 8 2 1
StatisticsValue
Average Number Of Links12.00
Average Number Of Links With An Hub7.00
Average Interaction Strength9.35
Average Nodes In Shell33.00
Average Hubs In Shell20.00
Average Links In Shell48.00
Average Links Mediated by Hubs In Shell47.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9M1H A Lipid Prostanoid EP1 Homo Sapiens Prostaglandin E2 - chim(NtGi1-Gs-CtGq)/Beta1/Gamma2 2.55 2025-04-09 To be published

A 2D representation of the interactions of P2E in 9M1H
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:P39 4.91 2 Yes No 0 8 0 1
L:L:?1 R:R:S42 5.61 2 Yes No 0 9 0 1
L:L:?1 R:R:H88 7.69 2 Yes Yes 0 9 0 1
L:L:?1 R:R:G92 5.12 2 Yes No 0 9 0 1
L:L:?1 R:R:V95 11.14 2 Yes No 0 9 0 1
L:L:?1 R:R:Y99 5.26 2 Yes Yes 0 9 0 1
L:L:?1 R:R:M117 14.8 2 Yes No 0 9 0 1
L:L:?1 R:R:G121 3.84 2 Yes No 0 7 0 1
L:L:?1 R:R:T186 4.41 2 Yes No 0 9 0 1
L:L:?1 R:R:W187 5.11 2 Yes Yes 0 9 0 1
L:L:?1 R:R:F334 5.46 2 Yes Yes 0 8 0 1
L:L:?1 R:R:V337 6.68 2 Yes No 0 8 0 1
L:L:?1 R:R:R338 9.08 2 Yes No 0 9 0 1
L:L:?1 R:R:S341 11.23 2 Yes No 0 8 0 1
L:L:?1 R:R:Q344 8.96 2 Yes Yes 0 9 0 1
R:R:P36 R:R:Y99 4.17 0 No Yes 6 9 2 1
R:R:L38 R:R:R338 10.93 0 No No 6 9 2 1
R:R:P39 R:R:V95 3.53 2 No No 8 9 1 1
R:R:P39 R:R:Y99 8.34 2 No Yes 8 9 1 1
R:R:S341 R:R:S42 3.26 2 No No 8 9 1 1
R:R:I345 R:R:S42 4.64 2 Yes No 9 9 2 1
R:R:G46 R:R:H88 7.94 2 No Yes 9 9 2 1
R:R:G46 R:R:I345 7.05 2 No Yes 9 9 2 2
R:R:D84 R:R:N50 6.73 2 Yes Yes 9 9 2 2
R:R:H88 R:R:N50 5.1 2 Yes Yes 9 9 1 2
R:R:D84 R:R:P124 3.22 2 Yes No 9 8 2 2
R:R:D84 R:R:Q344 7.83 2 Yes Yes 9 9 2 1
R:R:H88 R:R:I345 5.3 2 Yes Yes 9 9 1 2
R:R:G92 R:R:V95 3.68 2 No No 9 9 1 1
R:R:T186 R:R:Y99 17.48 2 No Yes 9 9 1 1
R:R:P124 R:R:Q344 9.47 2 No Yes 8 9 2 1
R:R:Q182 R:R:W187 20.81 2 No Yes 9 9 2 1
R:R:F189 R:R:Q182 4.68 2 Yes No 9 9 2 2
R:R:P184 R:R:W187 9.46 2 No Yes 9 9 2 1
R:R:F334 R:R:P184 17.34 2 Yes No 8 9 1 2
R:R:F189 R:R:W187 5.01 2 Yes Yes 9 9 2 1
R:R:F334 R:R:W187 8.02 2 Yes Yes 8 9 1 1
R:R:V337 R:R:W187 9.81 2 No Yes 8 9 1 1
R:R:F189 R:R:M313 3.73 2 Yes Yes 9 8 2 2
R:R:N343 R:R:W310 11.3 2 Yes Yes 9 9 2 2
R:R:Q344 R:R:W310 8.76 2 Yes Yes 9 9 1 2
R:R:M313 R:R:V337 4.56 0 Yes No 8 8 2 1
R:R:F334 R:R:R338 17.1 2 Yes No 8 9 1 1
R:R:N343 R:R:Q344 7.92 2 Yes Yes 9 9 2 1
L:L:?1 R:R:M43 3.17 2 Yes Yes 0 8 0 1
R:R:M43 R:R:T44 3.01 0 Yes No 8 6 1 2
R:R:I40 R:R:M43 2.92 0 No Yes 7 8 2 1
R:R:L96 R:R:M43 2.83 0 No Yes 8 8 2 1
R:R:A34 R:R:Y99 1.33 0 No Yes 3 9 2 1
StatisticsValue
Average Number Of Links16.00
Average Number Of Links With An Hub6.00
Average Interaction Strength7.03
Average Nodes In Shell34.00
Average Hubs In Shell14.00
Average Links In Shell49.00
Average Links Mediated by Hubs In Shell45.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links14.73
Average Number Of Links With An Hub5.67
Average Interaction Strength7.43
Average Nodes In Shell32.80
Average Hubs In Shell12.80
Average Links In Shell45.00
Average Links Mediated by Hubs In Shell40.20

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Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

missing image


Location of the nodes interacting with this ligand

(Click to enlarge 🔍)