CodeP2E
NameDinoprostone
SynonymsDinoprostone Prostaglandin E2
Identifier(Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxo-cyclopentyl]hept-5-enoic acid
FormulaC20 H32 O5
Molecular Weight352.465
SMILESCCCCC[C@@H](\C=C\[C@H]1[C@@H](CC(=O)[C@@H]1C\C=C/CCCC(=O)O)O)O
PubChem5280360
Formal Charge0
Total Atoms57
Total Chiral Atoms4
Total Bonds57
Total Aromatic Bonds0
Networks7
 missing image

This ligand is also present in the following 7 networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
6AK3 A Lipid Prostanoid EP3 Homo sapiens Dinoprostone IPGE2 - - 2.9 2018-12-05 10.1038/s41589-018-0171-8

A 2D representation of the interactions of P2E in 6AK3
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:V50 R:R:Y114 3.79 1 Yes Yes 4 8 2 1
R:R:V50 R:R:W203 3.68 1 Yes Yes 4 4 2 2
R:R:P204 R:R:V50 8.84 1 No Yes 7 4 2 2
R:R:V52 R:R:Y114 10.09 0 No Yes 5 8 2 1
R:R:F54 R:R:R333 17.1 0 No Yes 4 8 2 1
R:R:P55 R:R:V110 3.53 1 No No 7 8 1 1
L:L:?1 R:R:P55 3.41 1 Yes No 0 7 0 1
R:R:M58 R:R:R333 3.72 1 No Yes 8 8 1 1
R:R:I340 R:R:M58 4.37 0 No No 9 8 2 1
L:L:?1 R:R:M58 8.81 1 Yes No 0 8 0 1
R:R:L59 R:R:T107 13.27 0 No No 7 8 2 1
R:R:D99 R:R:S144 4.42 1 Yes No 9 8 2 2
R:R:D99 R:R:Q339 10.44 1 Yes Yes 9 8 2 1
R:R:D342 R:R:D99 7.98 1 Yes Yes 9 9 2 2
R:R:F133 R:R:T106 6.49 3 Yes No 6 6 2 1
R:R:T106 R:R:T136 3.14 0 No No 6 5 1 2
L:L:?1 R:R:T106 5.1 1 Yes No 0 6 0 1
R:R:P108 R:R:T107 3.5 0 No No 8 8 2 1
L:L:?1 R:R:T107 12.24 1 Yes No 0 8 0 1
R:R:T206 R:R:V110 3.17 1 Yes No 8 8 1 1
L:L:?1 R:R:V110 6.19 1 Yes No 0 8 0 1
R:R:T206 R:R:V113 4.76 1 Yes No 8 7 1 2
R:R:T206 R:R:Y114 14.98 1 Yes Yes 8 8 1 1
L:L:?1 R:R:Y114 7.3 1 Yes Yes 0 8 0 1
R:R:F133 R:R:M137 4.98 3 Yes No 6 7 2 1
L:L:?1 R:R:M137 9.79 1 Yes No 0 7 0 1
R:R:Q339 R:R:S144 8.66 1 Yes No 8 8 1 2
R:R:D342 R:R:S144 5.89 1 Yes No 9 8 2 2
R:R:L145 R:R:W295 20.5 0 No Yes 8 8 2 1
R:R:Q202 R:R:W207 16.43 1 No Yes 8 7 2 1
R:R:F209 R:R:Q202 3.51 1 No No 8 8 2 2
R:R:F328 R:R:Q202 3.51 1 Yes No 6 8 2 2
R:R:P204 R:R:W203 20.27 1 No Yes 7 4 2 2
R:R:L329 R:R:W203 4.56 1 Yes Yes 7 4 1 2
R:R:P204 R:R:T206 3.5 1 No Yes 7 8 2 1
R:R:T206 R:R:W207 3.64 1 Yes Yes 8 7 1 1
L:L:?1 R:R:T206 7.14 1 Yes Yes 0 8 0 1
R:R:F209 R:R:W207 5.01 1 No Yes 8 7 2 1
R:R:F328 R:R:W207 5.01 1 Yes Yes 6 7 2 1
R:R:L329 R:R:W207 4.56 1 Yes Yes 7 7 1 1
R:R:V332 R:R:W207 13.48 1 No Yes 7 7 1 1
L:L:?1 R:R:W207 11.04 1 Yes Yes 0 7 0 1
R:R:F209 R:R:F328 3.22 1 No Yes 8 6 2 2
R:R:L299 R:R:W295 3.42 0 No Yes 8 8 2 1
R:R:A335 R:R:W295 7.78 0 No Yes 8 8 2 1
R:R:N338 R:R:W295 9.04 1 Yes Yes 9 8 2 1
R:R:Q339 R:R:W295 4.38 1 Yes Yes 8 8 1 1
L:L:?1 R:R:W295 3.15 1 Yes Yes 0 8 0 1
R:R:L329 R:R:R333 12.15 1 Yes Yes 7 8 1 1
L:L:?1 R:R:L329 5.75 1 Yes Yes 0 7 0 1
L:L:?1 R:R:V332 6.19 1 Yes No 0 7 0 1
L:L:?1 R:R:R333 5.05 1 Yes Yes 0 8 0 1
L:L:?1 R:R:S336 19.75 1 Yes No 0 8 0 1
R:R:N338 R:R:Q339 7.92 1 Yes Yes 9 8 2 1
R:R:D342 R:R:N338 6.73 1 Yes Yes 9 9 2 2
R:R:D342 R:R:Q339 3.92 1 Yes Yes 9 8 2 1
L:L:?1 R:R:Q339 9.21 1 Yes Yes 0 8 0 1
R:R:G141 R:R:W295 2.81 0 No Yes 7 8 2 1
StatisticsValue
Average Number Of Links15.00
Average Number Of Links With An Hub7.00
Average Interaction Strength8.01
Average Nodes In Shell38.00
Average Hubs In Shell15.00
Average Links In Shell58.00
Average Links Mediated by Hubs In Shell52.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
6AK3_poly A Lipid Prostanoid EP3 Homo sapiens Dinoprostone IPGE2 - - 2.9 2018-12-05 10.1038/s41589-018-0171-8

A 2D representation of the interactions of P2E in 6AK3_poly
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
S:S:V50 S:S:Y114 3.79 1 Yes Yes 4 8 2 1
S:S:V50 S:S:W203 3.68 1 Yes Yes 4 4 2 2
S:S:P204 S:S:V50 8.84 1 No Yes 7 4 2 2
S:S:I111 S:S:V52 4.61 0 No No 7 5 2 2
S:S:V52 S:S:Y114 10.09 0 No Yes 5 8 2 1
S:S:F54 S:S:R333 17.1 0 Yes Yes 4 8 2 1
S:S:P55 S:S:V110 3.53 1 No No 7 8 1 1
M:M:?1 S:S:P55 3.41 1 Yes No 0 7 0 1
S:S:M58 S:S:R333 3.72 1 No Yes 8 8 1 1
S:S:I340 S:S:M58 4.37 0 No No 9 8 2 1
M:M:?1 S:S:M58 8.81 1 Yes No 0 8 0 1
S:S:L59 S:S:T107 13.27 0 No Yes 7 8 2 1
S:S:D99 S:S:S144 4.42 1 Yes No 9 8 2 2
S:S:D99 S:S:Q339 10.44 1 Yes Yes 9 8 2 1
S:S:D342 S:S:D99 7.98 1 Yes Yes 9 9 2 2
S:S:F133 S:S:T106 6.49 6 Yes No 6 6 2 1
S:S:T106 S:S:T136 3.14 0 No No 6 5 1 2
M:M:?1 S:S:T106 5.1 1 Yes No 0 6 0 1
S:S:P108 S:S:T107 3.5 0 No Yes 8 8 2 1
S:S:I111 S:S:T107 3.04 0 No Yes 7 8 2 1
M:M:?1 S:S:T107 12.24 1 Yes Yes 0 8 0 1
S:S:T206 S:S:V110 3.17 1 Yes No 8 8 1 1
M:M:?1 S:S:V110 6.19 1 Yes No 0 8 0 1
S:S:T206 S:S:V113 4.76 1 Yes No 8 7 1 2
S:S:T206 S:S:Y114 14.98 1 Yes Yes 8 8 1 1
M:M:?1 S:S:Y114 7.3 1 Yes Yes 0 8 0 1
S:S:F133 S:S:M137 4.98 6 Yes No 6 7 2 1
M:M:?1 S:S:M137 9.79 1 Yes No 0 7 0 1
S:S:Q339 S:S:S144 8.66 1 Yes No 8 8 1 2
S:S:D342 S:S:S144 5.89 1 Yes No 9 8 2 2
S:S:L145 S:S:W295 20.5 0 No Yes 8 8 2 1
S:S:Q202 S:S:W207 16.43 1 No Yes 8 7 2 1
S:S:F209 S:S:Q202 3.51 1 No No 8 8 2 2
S:S:F328 S:S:Q202 3.51 1 Yes No 6 8 2 2
S:S:P204 S:S:W203 20.27 1 No Yes 7 4 2 2
S:S:L329 S:S:W203 4.56 1 Yes Yes 7 4 1 2
S:S:P204 S:S:T206 3.5 1 No Yes 7 8 2 1
S:S:T206 S:S:W207 3.64 1 Yes Yes 8 7 1 1
M:M:?1 S:S:T206 7.14 1 Yes Yes 0 8 0 1
S:S:F209 S:S:W207 5.01 1 No Yes 8 7 2 1
S:S:F328 S:S:W207 5.01 1 Yes Yes 6 7 2 1
S:S:L329 S:S:W207 4.56 1 Yes Yes 7 7 1 1
S:S:V332 S:S:W207 13.48 1 No Yes 7 7 1 1
M:M:?1 S:S:W207 11.04 1 Yes Yes 0 7 0 1
S:S:F209 S:S:F328 3.22 1 No Yes 8 6 2 2
S:S:L299 S:S:W295 3.42 0 No Yes 8 8 2 1
S:S:A335 S:S:W295 7.78 0 No Yes 8 8 2 1
S:S:N338 S:S:W295 9.04 1 Yes Yes 9 8 2 1
S:S:Q339 S:S:W295 4.38 1 Yes Yes 8 8 1 1
M:M:?1 S:S:W295 3.15 1 Yes Yes 0 8 0 1
S:S:L329 S:S:R333 12.15 1 Yes Yes 7 8 1 1
M:M:?1 S:S:L329 5.75 1 Yes Yes 0 7 0 1
M:M:?1 S:S:V332 6.19 1 Yes No 0 7 0 1
M:M:?1 S:S:R333 5.05 1 Yes Yes 0 8 0 1
M:M:?1 S:S:S336 19.75 1 Yes No 0 8 0 1
S:S:N338 S:S:Q339 7.92 1 Yes Yes 9 8 2 1
S:S:D342 S:S:N338 6.73 1 Yes Yes 9 9 2 2
S:S:D342 S:S:Q339 3.92 1 Yes Yes 9 8 2 1
M:M:?1 S:S:Q339 9.21 1 Yes Yes 0 8 0 1
S:S:G141 S:S:W295 2.81 0 No Yes 7 8 2 1
StatisticsValue
Average Number Of Links15.00
Average Number Of Links With An Hub8.00
Average Interaction Strength8.01
Average Nodes In Shell39.00
Average Hubs In Shell17.00
Average Links In Shell60.00
Average Links Mediated by Hubs In Shell55.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of P2E in 6AK3_poly
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:L329 R:R:S49 4.5 2 Yes No 7 4 1 2
R:R:V50 R:R:Y114 3.79 0 No Yes 4 8 2 1
R:R:P204 R:R:V50 8.84 0 No No 7 4 2 2
R:R:I111 R:R:V52 4.61 0 No No 7 5 2 2
R:R:V52 R:R:Y114 10.09 0 No Yes 5 8 2 1
R:R:F54 R:R:R333 17.1 0 Yes Yes 4 8 2 1
R:R:P55 R:R:V110 3.53 2 No No 7 8 1 1
L:L:?1 R:R:P55 3.41 2 Yes No 0 7 0 1
R:R:M58 R:R:R333 3.72 2 No Yes 8 8 1 1
R:R:I340 R:R:M58 4.37 0 No No 9 8 2 1
L:L:?1 R:R:M58 9.79 2 Yes No 0 8 0 1
R:R:L59 R:R:T107 13.27 0 No Yes 7 8 2 1
R:R:G62 R:R:Q103 4.93 0 No No 9 8 2 1
R:R:G62 R:R:I340 3.53 0 No No 9 9 2 2
R:R:D99 R:R:N66 5.39 2 Yes Yes 9 9 2 2
R:R:N66 R:R:Q103 3.96 0 Yes No 9 8 2 1
R:R:D99 R:R:Q339 10.44 2 Yes Yes 9 8 2 1
R:R:D342 R:R:D99 7.98 2 Yes Yes 9 9 2 2
L:L:?1 R:R:Q103 5.53 2 Yes No 0 8 0 1
R:R:F133 R:R:T106 6.49 5 Yes No 6 6 2 1
R:R:T106 R:R:T136 3.14 0 No No 6 5 1 2
L:L:?1 R:R:T106 5.1 2 Yes No 0 6 0 1
R:R:P108 R:R:T107 3.5 0 No Yes 8 8 2 1
R:R:I111 R:R:T107 3.04 0 No Yes 7 8 2 1
L:L:?1 R:R:T107 11.22 2 Yes Yes 0 8 0 1
L:L:?1 R:R:V110 6.19 2 Yes No 0 8 0 1
R:R:T206 R:R:V113 4.76 2 Yes No 8 7 1 2
R:R:T206 R:R:Y114 14.98 2 Yes Yes 8 8 1 1
L:L:?1 R:R:Y114 7.3 2 Yes Yes 0 8 0 1
R:R:F133 R:R:M137 6.22 5 Yes No 6 7 2 1
R:R:G134 R:R:M137 3.49 0 No No 7 7 2 1
L:L:?1 R:R:M137 10.77 2 Yes No 0 7 0 1
R:R:Q339 R:R:S144 8.66 2 Yes No 8 8 1 2
R:R:D342 R:R:S144 5.89 2 Yes No 9 8 2 2
R:R:Q202 R:R:W207 16.43 2 Yes Yes 8 7 2 1
R:R:F209 R:R:Q202 3.51 2 No Yes 8 8 2 2
R:R:F328 R:R:Q202 3.51 2 Yes Yes 6 8 2 2
R:R:P204 R:R:W203 20.27 0 No Yes 7 4 2 2
R:R:L329 R:R:W203 4.56 2 Yes Yes 7 4 1 2
R:R:P204 R:R:T206 3.5 0 No Yes 7 8 2 1
R:R:T206 R:R:W207 3.64 2 Yes Yes 8 7 1 1
L:L:?1 R:R:T206 6.12 2 Yes Yes 0 8 0 1
R:R:F209 R:R:W207 5.01 2 No Yes 8 7 2 1
R:R:F328 R:R:W207 5.01 2 Yes Yes 6 7 2 1
R:R:L329 R:R:W207 4.56 2 Yes Yes 7 7 1 1
R:R:V332 R:R:W207 13.48 2 No Yes 7 7 1 1
L:L:?1 R:R:W207 11.83 2 Yes Yes 0 7 0 1
R:R:F209 R:R:F328 3.22 2 No Yes 8 6 2 2
R:R:N338 R:R:W295 9.04 2 Yes Yes 9 8 2 2
R:R:Q339 R:R:W295 3.29 2 Yes Yes 8 8 1 2
R:R:L329 R:R:R333 12.15 2 Yes Yes 7 8 1 1
L:L:?1 R:R:L329 4.79 2 Yes Yes 0 7 0 1
L:L:?1 R:R:V332 6.19 2 Yes No 0 7 0 1
L:L:?1 R:R:R333 3.36 2 Yes Yes 0 8 0 1
L:L:?1 R:R:S336 19.75 2 Yes No 0 8 0 1
R:R:N338 R:R:Q339 7.92 2 Yes Yes 9 8 2 1
R:R:D342 R:R:N338 8.08 2 Yes Yes 9 9 2 2
R:R:D342 R:R:Q339 3.92 2 Yes Yes 9 8 2 1
L:L:?1 R:R:Q339 8.29 2 Yes Yes 0 8 0 1
StatisticsValue
Average Number Of Links15.00
Average Number Of Links With An Hub7.00
Average Interaction Strength7.98
Average Nodes In Shell40.00
Average Hubs In Shell18.00
Average Links In Shell59.00
Average Links Mediated by Hubs In Shell51.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7CX2 A Lipid Prostanoid EP2 Homo sapiens PGE2 - Gs/Beta1/Gamma2 2.8 2021-05-05 10.1126/sciadv.abf1268

A 2D representation of the interactions of P2E in 7CX2
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:E23 R:R:Y93 3.37 0 No Yes 1 7 2 1
R:R:E23 R:R:R302 4.65 0 No Yes 1 8 2 1
R:R:I27 R:R:R302 8.77 0 No Yes 4 8 2 1
L:L:?1 R:R:S28 8.32 6 Yes No 0 7 0 1
R:R:M31 R:R:R302 6.2 6 No Yes 8 8 1 1
L:L:?1 R:R:M31 5.87 6 Yes No 0 8 0 1
R:R:F32 R:R:V36 3.93 0 No No 8 7 2 2
R:R:F32 R:R:S86 9.25 0 No Yes 8 8 2 1
R:R:T82 R:R:V36 3.17 6 No No 8 7 1 2
R:R:D78 R:R:T123 4.34 24 Yes No 9 8 2 1
R:R:D78 R:R:S308 5.89 24 Yes No 9 8 2 1
R:R:S86 R:R:T82 3.2 6 Yes No 8 8 1 1
L:L:?1 R:R:T82 8.16 6 Yes No 0 8 0 1
R:R:F112 R:R:I85 6.28 0 No No 5 6 2 1
R:R:A115 R:R:I85 3.25 0 No No 5 6 2 1
L:L:?1 R:R:I85 4.94 6 Yes No 0 6 0 1
L:L:?1 R:R:S86 10.39 6 Yes Yes 0 8 0 1
R:R:T185 R:R:V89 3.17 0 No No 8 7 2 1
L:L:?1 R:R:V89 5.16 6 Yes No 0 7 0 1
R:R:T185 R:R:Y93 6.24 0 No Yes 8 7 2 1
L:L:?1 R:R:Y93 4.06 6 Yes Yes 0 7 0 1
R:R:F188 R:R:M116 3.73 16 Yes No 8 7 2 1
L:L:?1 R:R:M116 8.81 6 Yes No 0 7 0 1
L:L:?1 R:R:T123 5.1 6 Yes No 0 8 0 1
R:R:L207 R:R:M124 4.24 0 No No 7 7 2 1
R:R:P183 R:R:W186 8.11 6 No Yes 8 7 2 2
R:R:L298 R:R:P183 6.57 6 Yes No 6 8 1 2
R:R:L298 R:R:W186 6.83 6 Yes Yes 6 7 1 2
R:R:N307 R:R:S277 4.47 0 No Yes 9 9 1 2
R:R:L298 R:R:R302 8.5 6 Yes Yes 6 8 1 1
L:L:?1 R:R:L298 7.67 6 Yes Yes 0 6 0 1
R:R:Q299 R:R:R302 8.18 0 No Yes 4 8 2 1
L:L:?1 R:R:R302 6.73 6 Yes Yes 0 8 0 1
R:R:I309 R:R:S305 3.1 0 No No 9 8 2 1
L:L:?1 R:R:S305 11.43 6 Yes No 0 8 0 1
R:R:D311 R:R:N307 6.73 0 No No 9 9 2 1
L:L:?1 R:R:N307 6.65 6 Yes No 0 9 0 1
L:L:?1 R:R:S308 6.24 6 Yes No 0 8 0 1
L:L:?1 R:R:M124 2.94 6 Yes No 0 7 0 1
R:R:P87 R:R:S86 1.78 0 No Yes 7 8 2 1
R:R:P25 R:R:Y93 1.39 0 No Yes 5 7 2 1
StatisticsValue
Average Number Of Links15.00
Average Number Of Links With An Hub4.00
Average Interaction Strength6.83
Average Nodes In Shell34.00
Average Hubs In Shell9.00
Average Links In Shell41.00
Average Links Mediated by Hubs In Shell33.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7D7M A Lipid Prostanoid EP4 Homo sapiens Dinoprostone - Gs/Beta1/Gamma1 3.3 2020-11-18 10.1016/j.str.2020.11.007

A 2D representation of the interactions of P2E in 7D7M
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:V21 R:R:Y80 8.83 0 No Yes 6 6 2 1
R:R:I23 R:R:P24 3.39 0 No No 6 7 2 1
R:R:I23 R:R:R316 15.03 0 No Yes 6 7 2 1
R:R:P24 R:R:T76 3.5 5 No No 7 8 1 1
L:L:?1 R:R:P24 4.55 5 Yes No 0 7 0 1
R:R:M27 R:R:R316 6.2 5 Yes Yes 8 7 1 1
R:R:M27 R:R:S319 3.07 5 Yes No 8 8 1 1
R:R:M27 R:R:V320 3.04 5 Yes No 8 5 1 2
L:L:?1 R:R:M27 3.91 5 Yes Yes 0 8 0 1
R:R:F28 R:R:S73 10.57 0 No Yes 6 8 2 1
R:R:G31 R:R:I323 3.53 0 No No 8 8 2 1
R:R:D65 R:R:P322 4.83 20 No No 9 9 2 1
L:L:?1 R:R:T69 4.08 5 Yes No 0 8 0 1
R:R:I98 R:R:V72 3.07 0 Yes No 5 7 2 1
L:L:?1 R:R:V72 9.28 5 Yes No 0 7 0 1
R:R:I77 R:R:S73 3.1 0 No Yes 6 8 2 1
L:L:?1 R:R:S73 5.2 5 Yes Yes 0 8 0 1
L:L:?1 R:R:T76 9.18 5 Yes No 0 8 0 1
R:R:T168 R:R:T79 4.71 5 Yes No 6 7 1 2
R:R:T168 R:R:Y80 13.73 5 Yes Yes 6 6 1 1
L:L:?1 R:R:Y80 4.87 5 Yes Yes 0 6 0 1
L:L:?1 R:R:S103 5.2 5 Yes No 0 7 0 1
R:R:P166 R:R:T168 6.99 0 No Yes 6 6 2 1
L:L:?1 R:R:T168 7.14 5 Yes Yes 0 6 0 1
R:R:F171 R:R:W169 9.02 0 Yes No 6 5 2 1
R:R:I315 R:R:W169 11.74 0 No No 6 5 2 1
L:L:?1 R:R:W169 6.31 5 Yes No 0 5 0 1
R:R:L312 R:R:N309 4.12 5 No No 6 2 1 2
R:R:L312 R:R:R316 8.5 5 No Yes 6 7 1 1
L:L:?1 R:R:L312 6.71 5 Yes No 0 6 0 1
L:L:?1 R:R:R316 3.36 5 Yes Yes 0 7 0 1
L:L:?1 R:R:S319 8.32 5 Yes No 0 8 0 1
R:R:N321 R:R:P322 6.52 0 No No 9 9 2 1
L:L:?1 R:R:P322 3.41 5 Yes No 0 9 0 1
R:R:P20 R:R:Y80 2.78 0 No Yes 5 6 2 1
R:R:P74 R:R:S73 1.78 0 No Yes 9 8 2 1
L:L:?1 R:R:I323 0.99 5 Yes No 0 8 0 1
StatisticsValue
Average Number Of Links15.00
Average Number Of Links With An Hub5.00
Average Interaction Strength5.50
Average Nodes In Shell32.00
Average Hubs In Shell8.00
Average Links In Shell37.00
Average Links Mediated by Hubs In Shell30.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8GCP A Lipid Prostanoid EP4 Homo Sapiens PGE2 - Gi1/Beta1/Gamma2 3.1 2024-01-03 10.1073/pnas.2216329120

A 2D representation of the interactions of P2E in 8GCP
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:V21 R:R:Y80 17.66 0 No Yes 6 6 2 1
R:R:I23 R:R:P24 3.39 2 Yes No 6 7 2 1
R:R:I23 R:R:M27 2.92 2 Yes No 6 8 2 2
R:R:I23 R:R:R316 5.01 2 Yes Yes 6 7 2 1
R:R:P24 R:R:T76 3.5 2 No No 7 8 1 1
L:L:?1 R:R:P24 11.37 2 Yes No 0 7 0 1
R:R:M27 R:R:R316 3.72 2 No Yes 8 7 2 1
R:R:F28 R:R:S73 17.18 0 Yes No 6 8 2 1
R:R:D65 R:R:P322 9.66 34 No No 9 9 2 1
R:R:S73 R:R:T69 3.2 2 No No 8 8 1 1
L:L:?1 R:R:T69 6.12 2 Yes No 0 8 0 1
R:R:I98 R:R:V72 7.68 35 Yes No 5 7 2 1
L:L:?1 R:R:V72 5.16 2 Yes No 0 7 0 1
L:L:?1 R:R:S73 5.2 2 Yes No 0 8 0 1
R:R:T76 R:R:Y80 2.5 2 No Yes 8 6 1 1
L:L:?1 R:R:T76 9.18 2 Yes No 0 8 0 1
R:R:T168 R:R:T79 3.14 2 Yes No 6 7 1 2
R:R:T168 R:R:Y80 8.74 2 Yes Yes 6 6 1 1
L:L:?1 R:R:Y80 4.87 2 Yes Yes 0 6 0 1
L:L:?1 R:R:L99 5.75 2 Yes No 0 8 0 1
L:L:?1 R:R:S103 6.24 2 Yes No 0 7 0 1
R:R:Q164 R:R:W169 24.09 2 No Yes 7 5 2 1
R:R:F171 R:R:Q164 3.51 2 Yes No 6 7 2 2
R:R:P166 R:R:T168 3.5 2 No Yes 6 6 2 1
R:R:P166 R:R:W169 6.76 2 No Yes 6 5 2 1
R:R:L312 R:R:P166 6.57 2 Yes No 6 6 1 2
R:R:T168 R:R:W169 3.64 2 Yes Yes 6 5 1 1
L:L:?1 R:R:T168 4.08 2 Yes Yes 0 6 0 1
R:R:F171 R:R:W169 3.01 2 Yes Yes 6 5 2 1
R:R:I315 R:R:W169 10.57 2 No Yes 6 5 1 1
L:L:?1 R:R:W169 4.73 2 Yes Yes 0 5 0 1
R:R:L312 R:R:N309 5.49 2 Yes No 6 2 1 2
R:R:L312 R:R:R316 13.36 2 Yes Yes 6 7 1 1
L:L:?1 R:R:L312 8.62 2 Yes Yes 0 6 0 1
L:L:?1 R:R:I315 2.96 2 Yes No 0 6 0 1
L:L:?1 R:R:R316 8.41 2 Yes Yes 0 7 0 1
L:L:?1 R:R:S319 17.67 2 Yes No 0 8 0 1
L:L:?1 R:R:P322 3.41 2 Yes No 0 9 0 1
R:R:N321 R:R:P322 1.63 0 No No 9 9 2 1
StatisticsValue
Average Number Of Links15.00
Average Number Of Links With An Hub5.00
Average Interaction Strength6.92
Average Nodes In Shell28.00
Average Hubs In Shell10.00
Average Links In Shell39.00
Average Links Mediated by Hubs In Shell35.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8GDB A Lipid Prostanoid EP4 Homo Sapiens PGE2 - Gs/Beta1/Gamma2 3.1 2024-01-03 10.1073/pnas.2216329120

A 2D representation of the interactions of P2E in 8GDB
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:I23 R:R:P24 3.39 3 No No 6 7 2 1
R:R:I23 R:R:M27 2.92 3 No No 6 8 2 1
R:R:I23 R:R:R316 10.02 3 No Yes 6 7 2 1
R:R:P24 R:R:R316 4.32 3 No Yes 7 7 1 1
L:L:?1 R:R:P24 5.68 3 Yes No 0 7 0 1
L:L:?1 R:R:M27 5.87 3 Yes No 0 8 0 1
R:R:F28 R:R:S73 9.25 0 No Yes 6 8 2 1
R:R:D65 R:R:P322 8.05 15 Yes No 9 9 2 1
R:R:S73 R:R:T69 4.8 3 Yes No 8 8 1 1
L:L:?1 R:R:T69 4.08 3 Yes No 0 8 0 1
R:R:I98 R:R:V72 6.14 28 Yes No 5 7 2 1
L:L:?1 R:R:V72 5.16 3 Yes No 0 7 0 1
R:R:P74 R:R:S73 3.56 0 No Yes 9 8 2 1
L:L:?1 R:R:S73 7.28 3 Yes Yes 0 8 0 1
L:L:?1 R:R:T76 6.12 3 Yes No 0 8 0 1
L:L:?1 R:R:Y80 6.49 3 Yes No 0 6 0 1
R:R:F171 R:R:L99 4.87 0 Yes No 6 8 2 1
L:L:?1 R:R:L99 2.87 3 Yes No 0 8 0 1
R:R:F171 R:R:W169 3.01 0 Yes Yes 6 5 2 2
R:R:L312 R:R:W169 3.42 3 No Yes 6 5 1 2
R:R:I315 R:R:W169 16.44 0 No Yes 6 5 1 2
R:R:L312 R:R:R316 8.5 3 No Yes 6 7 1 1
L:L:?1 R:R:L312 4.79 3 Yes No 0 6 0 1
L:L:?1 R:R:I315 2.96 3 Yes No 0 6 0 1
L:L:?1 R:R:R316 10.09 3 Yes Yes 0 7 0 1
L:L:?1 R:R:S319 10.39 3 Yes No 0 8 0 1
L:L:?1 R:R:P322 4.55 3 Yes No 0 9 0 1
R:R:V21 R:R:Y80 2.52 0 No No 6 6 2 1
StatisticsValue
Average Number Of Links13.00
Average Number Of Links With An Hub2.00
Average Interaction Strength5.87
Average Nodes In Shell22.00
Average Hubs In Shell7.00
Average Links In Shell28.00
Average Links Mediated by Hubs In Shell25.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8GDC A Lipid Prostanoid EP3 Homo Sapiens PGE2 - Gi1/Beta1/Gamma2 3.5 2024-01-03 10.1073/pnas.2216329120

A 2D representation of the interactions of P2E in 8GDC
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:P55 R:R:V110 3.53 2 Yes Yes 7 8 1 2
R:R:I111 R:R:P55 5.08 0 No Yes 7 7 2 1
R:R:P55 R:R:Y114 4.17 2 Yes Yes 7 8 1 2
L:L:?1 R:R:P55 6.82 2 Yes Yes 0 7 0 1
R:R:M58 R:R:T57 3.01 2 No No 8 4 1 2
R:R:M58 R:R:R333 2.48 2 No No 8 8 1 1
L:L:?1 R:R:M58 11.74 2 Yes No 0 8 0 1
R:R:L59 R:R:T107 10.32 0 No Yes 7 8 2 1
L:L:?1 R:R:Q103 20.27 2 Yes No 0 8 0 1
R:R:F133 R:R:T106 7.78 2 Yes No 6 6 2 1
R:R:T106 R:R:T136 4.71 2 No Yes 6 5 1 2
L:L:?1 R:R:T106 3.06 2 Yes No 0 6 0 1
R:R:P108 R:R:T107 3.5 0 No Yes 8 8 2 1
R:R:I111 R:R:T107 3.04 0 No Yes 7 8 2 1
L:L:?1 R:R:T107 7.14 2 Yes Yes 0 8 0 1
R:R:V110 R:R:Y114 5.05 2 Yes Yes 8 8 2 2
R:R:F133 R:R:V110 2.62 2 Yes Yes 6 8 2 2
R:R:T206 R:R:V110 6.35 2 Yes Yes 8 8 2 2
R:R:T206 R:R:Y114 11.24 2 Yes Yes 8 8 2 2
R:R:F133 R:R:T136 2.59 2 Yes Yes 6 5 2 2
R:R:F133 R:R:M137 2.49 2 Yes Yes 6 7 2 1
R:R:F209 R:R:M137 8.71 2 No Yes 8 7 1 1
R:R:M137 R:R:V332 3.04 2 Yes No 7 7 1 2
L:L:?1 R:R:M137 13.7 2 Yes Yes 0 7 0 1
L:L:?1 R:R:G141 2.37 2 Yes No 0 7 0 1
R:R:L145 R:R:W295 14.81 0 No Yes 8 8 2 1
R:R:Q202 R:R:W207 15.33 0 No Yes 8 7 2 1
R:R:P204 R:R:W207 12.16 2 Yes Yes 7 7 2 1
R:R:L329 R:R:P204 9.85 2 Yes Yes 7 7 2 2
R:R:T206 R:R:W207 2.43 2 Yes Yes 8 7 2 1
R:R:F209 R:R:W207 8.02 2 No Yes 8 7 1 1
R:R:F328 R:R:W207 7.02 0 No Yes 6 7 2 1
R:R:V332 R:R:W207 3.68 0 No Yes 7 7 2 1
L:L:?1 R:R:W207 6.31 2 Yes Yes 0 7 0 1
L:L:?1 R:R:F209 2.53 2 Yes No 0 8 0 1
R:R:L299 R:R:W295 4.56 35 Yes Yes 8 8 2 1
R:R:A335 R:R:W295 5.19 0 No Yes 8 8 2 1
R:R:N338 R:R:W295 9.04 0 Yes Yes 9 8 2 1
L:L:?1 R:R:W295 3.15 2 Yes Yes 0 8 0 1
R:R:L329 R:R:R333 7.29 2 Yes No 7 8 2 1
L:L:?1 R:R:R333 10.09 2 Yes No 0 8 0 1
L:L:?1 R:R:S336 12.47 2 Yes No 0 8 0 1
R:R:F54 R:R:P55 1.44 0 No Yes 4 7 2 1
StatisticsValue
Average Number Of Links12.00
Average Number Of Links With An Hub5.00
Average Interaction Strength8.30
Average Nodes In Shell32.00
Average Hubs In Shell15.00
Average Links In Shell43.00
Average Links Mediated by Hubs In Shell41.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links14.38
Average Number Of Links With An Hub5.38
Average Interaction Strength7.18
Average Nodes In Shell33.12
Average Hubs In Shell12.38
Average Links In Shell45.62
Average Links Mediated by Hubs In Shell40.25

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Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

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Location of the nodes interacting with this ligand

(Click to enlarge 🔍)