psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	S:S:C47	S:S:V50	3.42	No	Yes	0	5	4
2	S:S:N326	S:S:S49	4.47	No	No	0	1	4
3	S:S:V50	S:S:Y114	3.79	Yes	Yes	1	4	8
4	S:S:V50	S:S:W203	3.68	Yes	Yes	1	4	4
5	S:S:P204	S:S:V50	8.84	No	Yes	1	7	4
6	S:S:I56	S:S:V52	4.61	No	No	0	4	5
7	S:S:I111	S:S:V52	4.61	No	No	0	7	5
8	S:S:V52	S:S:Y114	10.09	No	Yes	0	5	8
9	S:S:F54	S:S:R333	17.1	Yes	Yes	0	4	8
10	R:R:F54	S:S:F54	9.65	Yes	Yes	0	4	4
11	S:S:P55	S:S:V110	3.53	No	No	1	7	8
12	M:M:?1	S:S:P55	3.41	Yes	No	1	0	7
13	S:S:M58	S:S:R333	3.72	No	Yes	1	8	8
14	S:S:I340	S:S:M58	4.37	No	No	0	9	8
15	M:M:?1	S:S:M58	8.81	Yes	No	1	0	8
16	S:S:L59	S:S:T107	13.27	No	Yes	0	7	8
17	S:S:I340	S:S:T61	4.56	No	No	0	9	6
18	S:S:G62	S:S:Q103	4.93	No	No	0	9	8
19	S:S:G62	S:S:I340	3.53	No	No	0	9	9
20	S:S:F63	S:S:L100	8.53	No	No	0	7	7
21	S:S:G65	S:S:P343	4.06	No	Yes	4	9	9
22	S:S:G65	S:S:W344	4.22	No	Yes	4	9	8
23	S:S:A96	S:S:N66	4.69	No	Yes	0	9	9
24	S:S:D99	S:S:N66	5.39	Yes	Yes	0	9	9
25	S:S:N66	S:S:Q103	3.96	Yes	No	0	9	8
26	S:S:N66	S:S:P343	8.15	Yes	Yes	0	9	9
27	R:R:I352	S:S:L68	4.28	No	Yes	0	6	5
28	S:S:L97	S:S:M70	4.24	No	No	0	6	7
29	S:S:L347	S:S:L72	4.15	No	No	0	9	8
30	S:S:K351	S:S:L72	4.23	No	No	0	5	8
31	S:S:G93	S:S:V73	5.52	No	Yes	0	6	8
32	S:S:R75	S:S:S76	3.95	No	No	0	5	7
33	R:R:R355	S:S:R75	3.2	No	No	0	5	5
34	S:S:R78	S:S:Y77	6.17	No	No	0	4	6
35	S:S:L90	S:S:R78	14.58	No	No	0	6	4
36	S:S:R175	S:S:R78	7.46	No	No	0	5	4
37	S:S:M169	S:S:S87	6.13	Yes	No	0	5	6
38	S:S:S87	S:S:T174	3.2	No	No	0	6	6
39	S:S:C91	S:S:M151	6.48	No	No	0	7	9
40	S:S:I92	S:S:Y346	3.63	No	Yes	0	8	9
41	S:S:L178	S:S:W94	3.42	No	Yes	0	7	8
42	S:S:W182	S:S:W94	5.62	Yes	Yes	0	7	8
43	S:S:D99	S:S:L95	5.43	Yes	No	0	9	9
44	S:S:I147	S:S:L95	8.56	No	No	0	7	9
45	S:S:T98	S:S:W182	6.06	No	Yes	0	9	7
46	S:S:D99	S:S:S144	4.42	Yes	No	1	9	8
47	S:S:D99	S:S:Q339	10.44	Yes	Yes	1	9	8
48	S:S:D342	S:S:D99	7.98	Yes	Yes	1	9	9
49	S:S:L100	S:S:L104	6.92	No	No	0	7	5
50	S:S:F140	S:S:V101	5.24	No	No	0	8	5
51	S:S:F140	S:S:G102	10.54	No	No	0	8	8
52	S:S:F133	S:S:T106	6.49	Yes	No	0	6	6
53	S:S:T106	S:S:T136	3.14	No	No	0	6	5
54	M:M:?1	S:S:T106	5.1	Yes	No	0	0	6
55	S:S:P108	S:S:T107	3.5	No	Yes	0	8	8
56	S:S:I111	S:S:T107	3.04	No	Yes	0	7	8
57	M:M:?1	S:S:T107	12.24	Yes	Yes	0	0	8
58	S:S:L129	S:S:V109	4.47	No	No	0	5	6
59	S:S:F133	S:S:V109	5.24	Yes	No	0	6	6
60	S:S:T206	S:S:V110	3.17	Yes	No	1	8	8
61	M:M:?1	S:S:V110	6.19	Yes	No	1	0	8
62	S:S:V113	S:S:W120	4.9	No	Yes	0	7	5
63	S:S:T206	S:S:V113	4.76	Yes	No	0	8	7
64	S:S:T206	S:S:Y114	14.98	Yes	Yes	1	8	8
65	M:M:?1	S:S:Y114	7.3	Yes	Yes	1	0	8
66	S:S:I123	S:S:S116	4.64	No	No	0	3	4
67	S:S:H122	S:S:R119	10.16	No	No	0	3	4
68	S:S:D124	S:S:W120	7.82	Yes	Yes	0	6	5
69	S:S:C130	S:S:W120	5.22	No	Yes	6	9	5
70	S:S:F133	S:S:W120	4.01	Yes	Yes	6	6	5
71	S:S:V201	S:S:W120	6.13	Yes	Yes	6	5	5
72	S:S:C208	S:S:W120	5.22	Yes	Yes	6	9	5
73	S:S:D124	S:S:P125	3.22	Yes	No	0	6	4
74	S:S:D124	S:S:G127	5.03	Yes	No	0	6	3
75	S:S:D124	S:S:L129	6.79	Yes	No	0	6	5
76	S:S:C130	S:S:C208	7.28	No	Yes	6	9	9
77	S:S:F132	S:S:T136	7.78	No	No	0	4	5
78	S:S:F133	S:S:M137	4.98	Yes	No	0	6	7
79	S:S:C208	S:S:F133	4.19	Yes	Yes	6	9	6
80	S:S:G134	S:S:Y199	10.14	No	Yes	0	7	6
81	S:S:A189	S:S:L135	4.73	No	Yes	0	8	6
82	S:S:L135	S:S:Y199	3.52	Yes	Yes	0	6	6
83	M:M:?1	S:S:M137	9.79	Yes	No	0	0	7
84	S:S:A189	S:S:T138	3.36	No	No	0	8	7
85	S:S:T138	S:S:Y199	6.24	No	Yes	0	7	6
86	S:S:I210	S:S:T138	3.04	No	No	0	6	7
87	S:S:F140	S:S:V139	3.93	No	No	0	8	7
88	S:S:L142	S:S:S185	6.01	No	No	0	7	7
89	S:S:F188	S:S:L142	3.65	Yes	No	3	8	7
90	S:S:F234	S:S:L142	7.31	Yes	No	3	8	7
91	S:S:S143	S:S:S185	3.26	No	No	0	7	7
92	S:S:Q339	S:S:S144	8.66	Yes	No	1	8	8
93	S:S:D342	S:S:S144	5.89	Yes	No	1	9	8
94	S:S:L145	S:S:W295	20.5	No	Yes	0	8	8
95	S:S:F146	S:S:L237	3.65	No	No	0	6	5
96	S:S:A241	S:S:F146	8.32	No	No	0	7	6
97	S:S:I147	S:S:L178	4.28	No	No	0	7	7
98	S:S:I147	S:S:V181	3.07	No	No	0	7	6
99	S:S:S149	S:S:V244	4.85	No	No	0	6	5
100	S:S:S149	S:S:T245	4.8	No	No	0	6	9
101	S:S:M151	S:S:Y346	7.18	No	Yes	0	9	9
102	S:S:A152	S:S:C248	3.61	No	Yes	0	9	7
103	S:S:E154	S:S:Y165	3.37	No	No	8	8	8
104	S:S:E154	S:S:M169	5.41	No	Yes	8	8	5
105	S:S:Q283	S:S:R155	5.84	No	Yes	0	8	9
106	S:S:L284	S:S:R155	6.07	Yes	Yes	0	9	9
107	S:S:I287	S:S:R155	3.76	No	Yes	9	8	9
108	S:S:R155	S:S:Y346	3.09	Yes	Yes	9	9	9
109	S:S:A158	S:S:Y165	6.67	No	No	0	9	8
110	S:S:I159	S:S:R259	5.01	Yes	No	0	8	7
111	S:S:A161	S:S:H163	4.39	No	No	0	4	6
112	S:S:H163	S:S:P162	3.05	No	No	0	6	9
113	S:S:H168	S:S:W164	32.8	No	No	0	3	4
114	S:S:M169	S:S:Y165	21.55	Yes	No	8	5	8
115	S:S:H168	S:S:S167	9.76	No	No	0	3	4
116	S:S:R175	S:S:T171	5.17	No	No	0	5	4
117	S:S:R172	S:S:R175	8.53	No	No	0	5	5
118	S:S:F188	S:S:F230	12.86	Yes	Yes	3	8	6
119	S:S:F188	S:S:F234	3.22	Yes	Yes	3	8	8
120	S:S:F188	S:S:L237	4.87	Yes	No	0	8	5
121	S:S:L191	S:S:V196	5.96	No	No	0	7	4
122	S:S:F230	S:S:L191	8.53	Yes	No	0	6	7
123	S:S:G197	S:S:P192	4.06	No	No	3	7	9
124	S:S:P192	S:S:Y199	16.69	No	Yes	3	9	6
125	S:S:F230	S:S:P192	10.11	Yes	No	3	6	9
126	S:S:G197	S:S:N227	3.39	No	Yes	0	7	5
127	S:S:F230	S:S:G197	4.52	Yes	No	3	6	7
128	S:S:N227	S:S:Q198	9.24	Yes	No	0	5	2
129	S:S:F230	S:S:Y199	3.09	Yes	Yes	3	6	6
130	S:S:S211	S:S:T200	6.4	No	No	0	5	4
131	S:S:C208	S:S:V201	3.42	Yes	Yes	6	9	5
132	S:S:Q202	S:S:W207	16.43	No	Yes	1	8	7
133	S:S:F209	S:S:Q202	3.51	No	No	1	8	8
134	S:S:F328	S:S:Q202	3.51	Yes	No	1	6	8
135	S:S:P204	S:S:W203	20.27	No	Yes	1	7	4
136	S:S:C325	S:S:W203	10.45	No	Yes	0	3	4
137	S:S:N326	S:S:W203	4.52	No	Yes	0	1	4
138	S:S:L329	S:S:W203	4.56	Yes	Yes	1	7	4
139	S:S:P204	S:S:T206	3.5	No	Yes	1	7	8
140	S:S:T206	S:S:W207	3.64	Yes	Yes	1	8	7
141	M:M:?1	S:S:T206	7.14	Yes	Yes	1	0	8
142	S:S:F209	S:S:W207	5.01	No	Yes	1	8	7
143	S:S:F328	S:S:W207	5.01	Yes	Yes	1	6	7
144	S:S:L329	S:S:W207	4.56	Yes	Yes	1	7	7
145	S:S:V332	S:S:W207	13.48	No	Yes	1	7	7
146	M:M:?1	S:S:W207	11.04	Yes	Yes	1	0	7
147	S:S:F209	S:S:F328	3.22	No	Yes	1	8	6
148	S:S:F230	S:S:I210	8.79	Yes	No	0	6	6
149	S:S:F234	S:S:I210	5.02	Yes	No	0	8	6
150	S:S:M305	S:S:T212	10.54	No	No	0	6	6
151	S:S:I306	S:S:T212	3.04	Yes	No	0	5	6
152	S:S:I306	S:S:L228	5.71	Yes	No	0	5	4
153	S:S:A231	S:S:I306	3.25	No	Yes	0	6	5
154	S:S:I306	S:S:S232	7.74	Yes	No	0	5	4
155	S:S:F234	S:S:M302	3.73	Yes	No	0	8	7
156	S:S:A235	S:S:L303	3.15	No	No	0	8	5
157	S:S:G238	S:S:L299	3.42	No	No	0	7	8
158	S:S:L239	S:S:L299	4.15	No	No	0	6	8
159	S:S:L242	S:S:L291	5.54	No	No	0	8	9
160	S:S:N249	S:S:T245	4.39	No	No	0	9	9
161	S:S:F246	S:S:M288	12.44	No	No	0	5	8
162	S:S:F246	S:S:L291	3.65	No	No	0	5	9
163	S:S:F246	S:S:S292	3.96	No	No	0	5	6
164	S:S:L284	S:S:N249	9.61	Yes	No	0	9	9
165	S:S:M288	S:S:N249	7.01	No	No	0	8	9
166	S:S:L250	S:S:M288	7.07	No	No	0	4	8
167	S:S:I253	S:S:L284	7.14	Yes	Yes	0	6	9
168	S:S:D258	S:S:K254	8.3	No	No	0	4	3
169	S:S:L256	S:S:T277	8.84	No	No	0	8	8
170	S:S:L256	S:S:T280	4.42	No	No	0	8	8
171	S:S:R261	S:S:V257	7.85	No	No	0	4	5
172	S:S:C260	S:S:K263	4.85	No	No	0	5	4
173	S:S:C260	S:S:T277	8.45	No	No	0	5	8
174	S:S:K263	S:S:W273	8.12	No	No	0	4	4
175	S:S:G274	S:S:K263	3.49	No	No	0	5	4
176	S:S:E279	S:S:R275	4.65	No	No	0	7	6
177	S:S:Q283	S:S:R350	18.69	No	No	0	8	8
178	S:S:I287	S:S:Y346	10.88	No	Yes	9	8	9
179	S:S:L341	S:S:V290	5.96	No	No	0	7	8
180	S:S:L291	S:S:N338	6.87	No	Yes	0	9	9
181	S:S:C294	S:S:L337	4.76	No	No	0	8	4
182	S:S:C294	S:S:N338	6.3	No	Yes	0	8	9
183	S:S:L299	S:S:W295	3.42	No	Yes	0	8	8
184	S:S:A335	S:S:W295	7.78	No	Yes	0	8	8
185	S:S:N338	S:S:W295	9.04	Yes	Yes	1	9	8
186	S:S:Q339	S:S:W295	4.38	Yes	Yes	1	8	8
187	M:M:?1	S:S:W295	3.15	Yes	Yes	1	0	8
188	S:S:L298	S:S:M302	4.24	Yes	No	0	7	7
189	S:S:F328	S:S:L298	3.65	Yes	Yes	0	6	7
190	S:S:A331	S:S:L298	3.15	No	Yes	0	7	7
191	S:S:A335	S:S:L298	3.15	No	Yes	0	8	7
192	S:S:F328	S:S:M301	3.73	Yes	No	0	6	5
193	S:S:E324	S:S:M305	8.12	No	No	0	3	6
194	S:S:F328	S:S:M305	4.98	Yes	No	0	6	6
195	S:S:F307	S:S:I306	11.3	No	Yes	0	3	5
196	S:S:F327	S:S:K323	4.96	No	No	0	3	1
197	S:S:L329	S:S:R333	12.15	Yes	Yes	1	7	8
198	M:M:?1	S:S:L329	5.75	Yes	Yes	1	0	7
199	M:M:?1	S:S:V332	6.19	Yes	No	1	0	7
200	M:M:?1	S:S:R333	5.05	Yes	Yes	1	0	8
201	M:M:?1	S:S:S336	19.75	Yes	No	0	0	8
202	S:S:L337	S:S:L341	4.15	No	No	0	4	7
203	S:S:N338	S:S:Q339	7.92	Yes	Yes	1	9	8
204	S:S:D342	S:S:N338	6.73	Yes	Yes	1	9	9
205	S:S:D342	S:S:Q339	3.92	Yes	Yes	1	9	8
206	M:M:?1	S:S:Q339	9.21	Yes	Yes	1	0	8
207	S:S:P343	S:S:W344	4.05	Yes	Yes	4	9	8
208	S:S:L348	S:S:P343	3.28	No	Yes	4	8	9
209	S:S:L348	S:S:W344	14.81	No	Yes	4	8	8
210	R:R:W344	S:S:W344	3.75	Yes	Yes	4	8	8
211	S:S:V345	S:S:Y346	3.79	No	Yes	0	8	9
212	R:R:L68	S:S:I352	4.28	Yes	No	0	5	6
213	R:R:I352	S:S:I352	5.89	No	No	0	6	6
214	R:R:R75	S:S:R355	4.26	No	No	0	5	5
215	R:R:C47	R:R:V50	3.42	No	No	0	5	4
216	R:R:N326	R:R:S49	4.47	No	No	0	1	4
217	R:R:L329	R:R:S49	4.5	Yes	No	0	7	4
218	R:R:V50	R:R:Y114	3.79	No	Yes	0	4	8
219	R:R:P204	R:R:V50	8.84	No	No	0	7	4
220	R:R:I56	R:R:V52	6.14	No	No	0	4	5
221	R:R:I111	R:R:V52	4.61	No	No	0	7	5
222	R:R:V52	R:R:Y114	10.09	No	Yes	0	5	8
223	R:R:F54	R:R:R333	17.1	Yes	Yes	0	4	8
224	R:R:P55	R:R:V110	3.53	No	No	2	7	8
225	L:L:?1	R:R:P55	3.41	Yes	No	2	0	7
226	R:R:M58	R:R:R333	3.72	No	Yes	2	8	8
227	R:R:I340	R:R:M58	4.37	No	No	0	9	8
228	L:L:?1	R:R:M58	9.79	Yes	No	2	0	8
229	R:R:L59	R:R:T107	13.27	No	Yes	0	7	8
230	R:R:I340	R:R:T61	4.56	No	No	0	9	6
231	R:R:G62	R:R:Q103	4.93	No	No	0	9	8
232	R:R:G62	R:R:I340	3.53	No	No	0	9	9
233	R:R:F63	R:R:L100	6.09	No	No	0	7	7
234	R:R:G65	R:R:P343	4.06	No	Yes	4	9	9
235	R:R:G65	R:R:W344	4.22	No	Yes	4	9	8
236	R:R:A96	R:R:N66	4.69	No	Yes	0	9	9
237	R:R:D99	R:R:N66	5.39	Yes	Yes	0	9	9
238	R:R:N66	R:R:Q103	3.96	Yes	No	0	9	8
239	R:R:N66	R:R:P343	8.15	Yes	Yes	0	9	9
240	R:R:L97	R:R:M70	4.24	No	No	0	6	7
241	R:R:L347	R:R:L72	4.15	No	No	0	9	8
242	R:R:K351	R:R:L72	5.64	No	No	0	5	8
243	R:R:G93	R:R:V73	5.52	No	Yes	0	6	8
244	R:R:L90	R:R:R78	15.79	No	No	0	6	4
245	R:R:R175	R:R:R78	7.46	No	No	0	5	4
246	R:R:M169	R:R:S87	6.13	Yes	No	0	5	6
247	R:R:S87	R:R:T174	4.8	No	No	0	6	6
248	R:R:E154	R:R:F88	3.5	No	No	0	8	8
249	R:R:C91	R:R:M151	6.48	No	No	0	7	9
250	R:R:I92	R:R:Y346	3.63	No	Yes	0	8	9
251	R:R:L178	R:R:W94	3.42	No	Yes	0	7	8
252	R:R:W182	R:R:W94	3.75	Yes	Yes	0	7	8
253	R:R:D99	R:R:L95	5.43	Yes	No	0	9	9
254	R:R:I147	R:R:L95	8.56	No	No	0	7	9
255	R:R:T98	R:R:W182	6.06	No	Yes	0	9	7
256	R:R:D99	R:R:Q339	10.44	Yes	Yes	2	9	8
257	R:R:D342	R:R:D99	7.98	Yes	Yes	2	9	9
258	R:R:L100	R:R:L104	8.3	No	No	0	7	5
259	R:R:F140	R:R:V101	5.24	No	No	0	8	5
260	R:R:F140	R:R:G102	10.54	No	No	0	8	8
261	L:L:?1	R:R:Q103	5.53	Yes	No	0	0	8
262	R:R:F133	R:R:T106	6.49	Yes	No	0	6	6
263	R:R:T106	R:R:T136	3.14	No	No	0	6	5
264	L:L:?1	R:R:T106	5.1	Yes	No	0	0	6
265	R:R:P108	R:R:T107	3.5	No	Yes	0	8	8
266	R:R:I111	R:R:T107	3.04	No	Yes	0	7	8
267	L:L:?1	R:R:T107	11.22	Yes	Yes	0	0	8
268	R:R:V109	R:R:W120	3.68	No	Yes	5	6	5
269	R:R:F133	R:R:V109	5.24	Yes	No	5	6	6
270	L:L:?1	R:R:V110	6.19	Yes	No	2	0	8
271	R:R:V113	R:R:W120	3.68	No	Yes	0	7	5
272	R:R:T206	R:R:V113	4.76	Yes	No	0	8	7
273	R:R:T206	R:R:Y114	14.98	Yes	Yes	2	8	8
274	L:L:?1	R:R:Y114	7.3	Yes	Yes	2	0	8
275	R:R:I123	R:R:S116	4.64	No	No	0	3	4
276	R:R:H122	R:R:R119	11.28	No	No	0	3	4
277	R:R:D124	R:R:W120	7.82	Yes	Yes	0	6	5
278	R:R:C130	R:R:W120	6.53	No	Yes	5	9	5
279	R:R:F133	R:R:W120	4.01	Yes	Yes	5	6	5
280	R:R:V201	R:R:W120	6.13	Yes	Yes	5	5	5
281	R:R:C208	R:R:W120	6.53	Yes	Yes	5	9	5
282	R:R:E121	R:R:V201	4.28	No	Yes	0	2	5
283	R:R:D124	R:R:P125	3.22	Yes	No	0	6	4
284	R:R:D124	R:R:G127	5.03	Yes	No	0	6	3
285	R:R:D124	R:R:L129	6.79	Yes	No	0	6	5
286	R:R:C130	R:R:C208	7.28	No	Yes	5	9	9
287	R:R:F132	R:R:T136	7.78	No	No	0	4	5
288	R:R:F133	R:R:M137	6.22	Yes	No	0	6	7
289	R:R:C208	R:R:F133	4.19	Yes	Yes	5	9	6
290	R:R:G134	R:R:M137	3.49	No	No	0	7	7
291	R:R:G134	R:R:Y199	8.69	No	Yes	0	7	6
292	R:R:A189	R:R:L135	4.73	No	Yes	0	8	6
293	R:R:L135	R:R:Y199	3.52	Yes	Yes	0	6	6
294	L:L:?1	R:R:M137	10.77	Yes	No	0	0	7
295	R:R:A189	R:R:T138	3.36	No	No	0	8	7
296	R:R:T138	R:R:Y199	6.24	No	Yes	0	7	6
297	R:R:I210	R:R:T138	3.04	No	No	0	6	7
298	R:R:F140	R:R:V139	3.93	No	No	0	8	7
299	R:R:F234	R:R:L142	7.31	Yes	No	0	8	7
300	R:R:S143	R:R:S185	3.26	No	No	0	7	7
301	R:R:Q339	R:R:S144	8.66	Yes	No	2	8	8
302	R:R:D342	R:R:S144	5.89	Yes	No	2	9	8
303	R:R:L145	R:R:W295	19.36	No	Yes	0	8	8
304	R:R:F146	R:R:L237	3.65	No	No	0	6	5
305	R:R:A241	R:R:F146	8.32	No	No	0	7	6
306	R:R:I147	R:R:L178	4.28	No	No	0	7	7
307	R:R:I147	R:R:V181	3.07	No	No	0	7	6
308	R:R:S149	R:R:V244	4.85	No	No	0	6	5
309	R:R:S149	R:R:T245	4.8	No	No	0	6	9
310	R:R:M151	R:R:Y346	8.38	No	Yes	0	9	9
311	R:R:A152	R:R:T245	5.03	No	No	0	9	9
312	R:R:E154	R:R:Y165	3.37	No	No	12	8	8
313	R:R:E154	R:R:M169	5.41	No	Yes	12	8	5
314	R:R:Q283	R:R:R155	5.84	No	Yes	0	8	9
315	R:R:L284	R:R:R155	6.07	Yes	Yes	0	9	9
316	R:R:I287	R:R:R155	3.76	No	Yes	13	8	9
317	R:R:R155	R:R:Y346	3.09	Yes	Yes	13	9	9
318	R:R:A158	R:R:Y165	5.34	No	No	0	9	8
319	R:R:A251	R:R:R160	4.15	No	No	0	5	7
320	R:R:A255	R:R:R160	6.91	No	No	0	7	7
321	R:R:A161	R:R:H163	4.39	No	No	0	4	6
322	R:R:H163	R:R:P162	3.05	No	No	0	6	9
323	R:R:P162	R:R:R259	4.32	No	No	0	9	7
324	R:R:H168	R:R:W164	29.62	No	No	0	3	4
325	R:R:M169	R:R:Y165	21.55	Yes	No	12	5	8
326	R:R:H168	R:R:S167	9.76	No	No	0	3	4
327	R:R:R175	R:R:T171	5.17	No	No	0	5	4
328	R:R:R172	R:R:R175	8.53	No	No	0	5	5
329	R:R:F188	R:R:F230	12.86	Yes	Yes	0	8	6
330	R:R:F188	R:R:F234	3.22	Yes	Yes	0	8	8
331	R:R:F188	R:R:L237	4.87	Yes	No	0	8	5
332	R:R:L191	R:R:V196	5.96	No	No	0	7	4
333	R:R:F230	R:R:L191	8.53	Yes	No	0	6	7
334	R:R:G197	R:R:P192	4.06	No	No	7	7	9
335	R:R:P192	R:R:Y199	16.69	No	Yes	7	9	6
336	R:R:F230	R:R:P192	10.11	Yes	No	7	6	9
337	R:R:F230	R:R:G197	4.52	Yes	No	7	6	7
338	R:R:N227	R:R:Q198	9.24	No	No	0	5	2
339	R:R:F230	R:R:Y199	3.09	Yes	Yes	7	6	6
340	R:R:S211	R:R:T200	6.4	No	No	0	5	4
341	R:R:C208	R:R:V201	3.42	Yes	Yes	5	9	5
342	R:R:Q202	R:R:W207	16.43	Yes	Yes	2	8	7
343	R:R:F209	R:R:Q202	3.51	No	Yes	2	8	8
344	R:R:F328	R:R:Q202	3.51	Yes	Yes	2	6	8
345	R:R:P204	R:R:W203	20.27	No	Yes	0	7	4
346	R:R:C325	R:R:W203	10.45	No	Yes	0	3	4
347	R:R:N326	R:R:W203	4.52	No	Yes	0	1	4
348	R:R:L329	R:R:W203	4.56	Yes	Yes	0	7	4
349	R:R:P204	R:R:T206	3.5	No	Yes	0	7	8
350	R:R:T206	R:R:W207	3.64	Yes	Yes	2	8	7
351	L:L:?1	R:R:T206	6.12	Yes	Yes	2	0	8
352	R:R:F209	R:R:W207	5.01	No	Yes	2	8	7
353	R:R:F328	R:R:W207	5.01	Yes	Yes	2	6	7
354	R:R:L329	R:R:W207	4.56	Yes	Yes	2	7	7
355	R:R:V332	R:R:W207	13.48	No	Yes	2	7	7
356	L:L:?1	R:R:W207	11.83	Yes	Yes	2	0	7
357	R:R:F209	R:R:F328	3.22	No	Yes	2	8	6
358	R:R:F230	R:R:I210	8.79	Yes	No	0	6	6
359	R:R:F234	R:R:I210	3.77	Yes	No	0	8	6
360	R:R:M305	R:R:T212	10.54	No	No	0	6	6
361	R:R:I306	R:R:T212	3.04	Yes	No	0	5	6
362	R:R:I306	R:R:L228	5.71	Yes	No	0	5	4
363	R:R:A231	R:R:I306	3.25	No	Yes	0	6	5
364	R:R:I306	R:R:S232	7.74	Yes	No	0	5	4
365	R:R:F234	R:R:M302	3.73	Yes	No	0	8	7
366	R:R:A235	R:R:L303	3.15	No	No	0	8	5
367	R:R:G238	R:R:L299	3.42	No	No	0	7	8
368	R:R:L239	R:R:L299	4.15	No	No	0	6	8
369	R:R:L242	R:R:L291	5.54	No	Yes	0	8	9
370	R:R:F246	R:R:M288	12.44	No	No	0	5	8
371	R:R:F246	R:R:L291	3.65	No	Yes	0	5	9
372	R:R:L284	R:R:N249	9.61	Yes	No	0	9	9
373	R:R:I287	R:R:N249	4.25	No	No	0	8	9
374	R:R:M288	R:R:N249	7.01	No	No	0	8	9
375	R:R:L250	R:R:M288	7.07	No	No	0	4	8
376	R:R:I253	R:R:L284	5.71	No	Yes	0	6	9
377	R:R:D258	R:R:K254	8.3	No	No	0	4	3
378	R:R:L256	R:R:T277	8.84	No	No	0	8	8
379	R:R:L256	R:R:T280	4.42	No	No	0	8	8
380	R:R:R261	R:R:V257	7.85	No	No	0	4	5
381	R:R:C260	R:R:K263	3.23	No	No	0	5	4
382	R:R:C260	R:R:T277	8.45	No	No	0	5	8
383	R:R:A264	R:R:K263	3.21	No	No	0	3	4
384	R:R:K263	R:R:W273	19.73	No	No	0	4	4
385	R:R:E279	R:R:R275	8.14	No	No	0	7	6
386	R:R:Q283	R:R:R350	17.52	No	No	0	8	8
387	R:R:I287	R:R:Y346	10.88	No	Yes	13	8	9
388	R:R:L341	R:R:V290	4.47	No	No	0	7	8
389	R:R:L291	R:R:N338	5.49	Yes	Yes	0	9	9
390	R:R:C294	R:R:L337	4.76	No	No	0	8	4
391	R:R:C294	R:R:N338	7.87	No	Yes	0	8	9
392	R:R:L299	R:R:W295	3.42	No	Yes	0	8	8
393	R:R:A335	R:R:W295	7.78	No	Yes	0	8	8
394	R:R:N338	R:R:W295	9.04	Yes	Yes	2	9	8
395	R:R:Q339	R:R:W295	3.29	Yes	Yes	2	8	8
396	R:R:F328	R:R:L298	3.65	Yes	No	0	6	7
397	R:R:A331	R:R:L298	3.15	No	No	0	7	7
398	R:R:A335	R:R:L298	3.15	No	No	0	8	7
399	R:R:F328	R:R:M301	4.98	Yes	No	0	6	5
400	R:R:F328	R:R:M305	4.98	Yes	No	0	6	6
401	R:R:F307	R:R:I306	11.3	No	Yes	0	3	5
402	R:R:F327	R:R:K323	3.72	No	No	0	3	1
403	R:R:L329	R:R:R333	12.15	Yes	Yes	2	7	8
404	L:L:?1	R:R:L329	4.79	Yes	Yes	2	0	7
405	L:L:?1	R:R:V332	6.19	Yes	No	2	0	7
406	L:L:?1	R:R:R333	3.36	Yes	Yes	2	0	8
407	L:L:?1	R:R:S336	19.75	Yes	No	0	0	8
408	R:R:L337	R:R:L341	4.15	No	No	0	4	7
409	R:R:N338	R:R:Q339	7.92	Yes	Yes	2	9	8
410	R:R:D342	R:R:N338	8.08	Yes	Yes	2	9	9
411	R:R:D342	R:R:Q339	3.92	Yes	Yes	2	9	8
412	L:L:?1	R:R:Q339	8.29	Yes	Yes	2	0	8
413	R:R:P343	R:R:W344	4.05	Yes	Yes	4	9	8
414	R:R:L348	R:R:W344	12.53	No	Yes	0	8	8
415	R:R:V345	R:R:Y346	3.79	No	Yes	0	8	9
416	R:R:L89	R:R:S76	3	No	No	0	8	7
417	R:R:L142	R:R:S185	3	No	No	0	7	7
418	R:R:R259	R:R:W273	3	No	No	0	7	4
419	S:S:L105	S:S:V101	2.98	No	No	0	6	5
420	S:S:L135	S:S:V139	2.98	Yes	No	0	6	7
421	S:S:L157	S:S:V153	2.98	No	No	0	6	6
422	S:S:L194	S:S:V193	2.98	No	No	0	4	4
423	S:S:N227	S:S:S211	2.98	Yes	No	0	5	5
424	S:S:L289	S:S:V293	2.98	No	No	0	4	6
425	R:R:L68	R:R:V64	2.98	Yes	No	0	5	4
426	R:R:L105	R:R:V101	2.98	No	No	0	6	5
427	R:R:L135	R:R:V139	2.98	Yes	No	0	6	7
428	R:R:L186	R:R:V139	2.98	No	No	0	4	7
429	R:R:L157	R:R:V153	2.98	No	No	0	6	6
430	R:R:L240	R:R:V244	2.98	No	No	0	2	5
431	R:R:L289	R:R:V293	2.98	No	No	0	4	6
432	S:S:L178	S:S:T174	2.95	No	No	0	7	6
433	S:S:L284	S:S:T252	2.95	Yes	No	0	9	9
434	R:R:L178	R:R:T174	2.95	No	No	0	7	6
435	R:R:L291	R:R:T245	2.95	Yes	No	0	9	9
436	R:R:L284	R:R:T252	2.95	Yes	No	0	9	9
437	S:S:I173	S:S:M169	2.92	No	Yes	0	5	5
438	R:R:I173	R:R:M169	2.92	No	Yes	0	5	5
439	R:R:I300	R:R:K304	2.91	No	No	0	7	3
440	S:S:I92	S:S:L347	2.85	No	No	0	8	9
441	S:S:I111	S:S:L115	2.85	No	No	0	7	4
442	S:S:E121	S:S:V201	2.85	No	Yes	0	2	5
443	S:S:I330	S:S:L334	2.85	No	No	0	4	6
444	R:R:I92	R:R:L347	2.85	No	No	0	8	9
445	R:R:I111	R:R:L115	2.85	No	No	0	7	4
446	R:R:I330	R:R:L334	2.85	No	No	0	4	6
447	S:S:I330	S:S:N326	2.83	No	No	0	4	1
448	R:R:Q202	R:R:T200	2.83	Yes	No	0	8	4
449	R:R:I330	R:R:N326	2.83	No	No	0	4	1
450	S:S:K351	S:S:L354	2.82	No	No	0	5	7
451	R:R:K351	R:R:L354	2.82	No	No	0	5	7
452	S:S:G141	S:S:W295	2.81	No	Yes	0	7	8
453	R:R:G141	R:R:W295	2.81	No	Yes	0	7	8
454	R:R:F54	S:S:A53	2.77	Yes	No	0	4	4
455	R:R:A53	S:S:F54	2.77	No	Yes	0	4	4
456	S:S:L348	S:S:L68	2.77	No	Yes	0	8	5
457	S:S:L179	S:S:L183	2.77	No	No	10	3	3
458	S:S:A233	S:S:F188	2.77	No	Yes	0	5	8
459	R:R:L348	R:R:L68	2.77	No	Yes	0	8	5
460	R:R:L179	R:R:L183	2.77	No	No	14	3	3
461	R:R:A233	R:R:F188	2.77	No	Yes	0	5	8
462	S:S:L100	S:S:N66	2.75	No	Yes	0	7	9
463	R:R:L100	R:R:N66	2.75	No	Yes	0	7	9
464	S:S:F54	S:S:S51	2.64	Yes	No	0	4	7
465	R:R:F54	R:R:S51	2.64	Yes	No	0	4	7
466	R:R:R75	R:R:S76	2.64	No	No	0	5	7
467	R:R:F246	R:R:S292	2.64	No	No	0	5	6
468	S:S:F229	S:S:V196	2.62	No	No	0	4	4
469	R:R:F229	R:R:V196	2.62	No	No	0	4	4
470	S:S:F327	S:S:M301	2.49	No	No	0	3	5
471	R:R:F327	R:R:M301	2.49	No	No	0	3	5
472	S:S:F146	S:S:L240	2.44	No	No	0	6	2
473	S:S:L129	S:S:R128	2.43	No	No	0	5	2
474	R:R:L129	R:R:R128	2.43	No	No	0	5	2
475	S:S:E154	S:S:F88	2.33	No	No	0	8	8
476	R:R:E121	R:R:R119	2.33	No	No	0	2	4
477	S:S:L90	S:S:W94	2.28	No	Yes	0	6	8
478	S:S:L97	S:S:W94	2.28	No	Yes	0	6	8
479	R:R:L90	R:R:W94	2.28	No	Yes	0	6	8
480	R:R:L97	R:R:W94	2.28	No	Yes	0	6	8
481	R:R:C260	R:R:G274	1.96	No	No	0	5	5
482	S:S:A69	S:S:P343	1.87	No	Yes	0	9	9
483	S:S:A331	S:S:P297	1.87	No	No	0	7	9
484	R:R:A69	R:R:P343	1.87	No	Yes	0	9	9
485	R:R:A331	R:R:P297	1.87	No	No	0	7	9
486	S:S:G127	S:S:S126	1.86	No	No	0	3	4
487	S:S:G65	S:S:V64	1.84	No	No	0	9	4
488	S:S:G205	S:S:V201	1.84	No	Yes	0	6	5
489	R:R:G205	R:R:V201	1.84	No	Yes	0	6	5
490	S:S:A156	S:S:C248	1.81	No	Yes	0	6	7
491	R:R:A152	R:R:C248	1.81	No	No	0	9	7
492	R:R:A156	R:R:C248	1.81	No	No	0	6	7
493	S:S:P297	S:S:S296	1.78	No	No	0	9	6
494	R:R:P297	R:R:S296	1.78	No	No	0	9	6
495	S:S:C248	S:S:V153	1.71	Yes	No	0	7	6
496	S:S:G213	S:S:L228	1.71	No	No	0	3	4
497	S:S:C248	S:S:V244	1.71	Yes	No	0	7	5
498	S:S:G286	S:S:L289	1.71	No	No	0	5	4
499	R:R:C248	R:R:V153	1.71	No	No	0	7	6
500	R:R:G286	R:R:L289	1.71	No	No	0	5	4
501	S:S:A150	S:S:V177	1.7	No	No	0	7	5
502	S:S:G226	S:S:N227	1.7	No	Yes	0	1	5
503	R:R:A150	R:R:V177	1.7	No	No	0	7	5
504	R:R:G197	R:R:N227	1.7	No	No	0	7	5
505	R:R:G226	R:R:N227	1.7	No	No	0	1	5
506	S:S:I159	S:S:P162	1.69	Yes	No	0	8	9
507	R:R:I159	R:R:P162	1.69	No	No	0	8	9
508	S:S:S74	S:S:V73	1.62	No	Yes	0	3	8
509	S:S:A255	S:S:I159	1.62	No	Yes	0	7	8
510	S:S:A281	S:S:I253	1.62	No	Yes	0	7	6
511	S:S:S292	S:S:V293	1.62	No	No	0	6	6
512	R:R:S74	R:R:V73	1.62	No	Yes	0	3	8
513	R:R:A255	R:R:I159	1.62	No	No	0	7	8
514	R:R:S292	R:R:V293	1.62	No	No	0	6	6
515	R:R:A148	R:R:M151	1.61	No	No	0	8	9
516	S:S:S247	S:S:T243	1.6	No	No	0	3	4
517	R:R:S247	R:R:T243	1.6	No	No	0	3	4
518	S:S:T131	S:S:V193	1.59	No	No	0	5	4
519	R:R:T131	R:R:V193	1.59	No	No	0	5	4
520	S:S:T57	S:S:T61	1.57	No	No	0	4	6
521	S:S:T277	S:S:T278	1.57	No	No	0	8	5
522	R:R:T57	R:R:T61	1.57	No	No	0	4	6
523	R:R:T277	R:R:T278	1.57	No	No	0	8	5
524	S:S:I300	S:S:S296	1.55	No	No	0	7	6
525	S:S:I123	S:S:V113	1.54	No	No	0	3	7
526	S:S:I173	S:S:V177	1.54	No	No	0	5	5
527	S:S:I253	S:S:V257	1.54	Yes	No	0	6	5
528	R:R:I123	R:R:V113	1.54	No	No	0	3	7
529	R:R:I173	R:R:V177	1.54	No	No	0	5	5
530	R:R:I253	R:R:V257	1.54	No	No	0	6	5
531	S:S:I159	S:S:T252	1.52	Yes	No	0	8	9
532	S:S:I276	S:S:T280	1.52	No	No	0	6	8
533	R:R:I159	R:R:T252	1.52	No	No	0	8	9
534	R:R:I276	R:R:T280	1.52	No	No	0	6	8
535	S:S:L89	S:S:S76	1.5	No	No	0	8	7
536	S:S:L89	S:S:V73	1.49	No	Yes	0	8	8
537	S:S:L347	S:S:V73	1.49	No	Yes	0	9	8
538	S:S:L186	S:S:V139	1.49	No	No	0	4	7
539	R:R:L89	R:R:V73	1.49	No	Yes	0	8	8
540	R:R:L347	R:R:V73	1.49	No	Yes	0	9	8
541	R:R:L194	R:R:V193	1.49	No	No	0	4	4
542	S:S:I253	S:S:M285	1.46	Yes	No	0	6	6
543	S:S:I282	S:S:M285	1.46	No	No	0	5	6
544	R:R:I253	R:R:M285	1.46	No	No	0	6	6
545	R:R:D258	R:R:V257	1.46	No	No	0	4	5
546	R:R:I282	R:R:M285	1.46	No	No	0	5	6
547	S:S:I300	S:S:K304	1.45	No	No	0	7	3
548	S:S:I56	S:S:L60	1.43	No	No	0	4	5
549	S:S:I159	S:S:L256	1.43	Yes	No	0	8	8
550	R:R:I56	R:R:L60	1.43	No	No	0	4	5
551	R:R:E279	R:R:T278	1.41	No	No	0	7	5
552	R:R:A67	R:R:F63	1.39	No	No	0	5	7
553	R:R:L349	S:S:L68	1.38	No	Yes	0	7	5
554	R:R:L353	S:S:L68	1.38	No	Yes	0	7	5
555	S:S:L71	S:S:L72	1.38	No	No	0	4	8
556	R:R:L353	S:S:L71	1.38	No	No	0	7	4
557	S:S:L135	S:S:L190	1.38	Yes	No	0	6	6
558	S:S:A176	S:S:R172	1.38	No	No	0	3	5
559	S:S:L190	S:S:L194	1.38	No	No	0	6	4
560	S:S:L239	S:S:L303	1.38	No	No	11	6	5
561	R:R:L68	S:S:L349	1.38	Yes	No	0	5	7
562	R:R:L68	S:S:L353	1.38	Yes	No	0	5	7
563	R:R:L71	S:S:L353	1.38	No	No	0	4	7
564	R:R:L71	R:R:L72	1.38	No	No	0	4	8
565	R:R:L135	R:R:L190	1.38	Yes	No	0	6	6
566	R:R:A176	R:R:R172	1.38	No	No	0	3	5
567	R:R:L186	R:R:L190	1.38	No	No	0	4	6
568	R:R:L239	R:R:L303	1.38	No	No	15	6	5
569	S:S:A148	S:S:Y346	1.33	No	Yes	0	8	9
570	S:S:A161	S:S:W164	1.3	No	No	0	4	4
571	R:R:A161	R:R:W164	1.3	No	No	0	4	4
572	R:R:T131	R:R:Y199	1.25	No	Yes	0	5	6
573	S:S:F236	S:S:L239	1.22	No	No	11	4	6
574	S:S:F236	S:S:L303	1.22	No	No	11	4	5
575	R:R:F236	R:R:L239	1.22	No	No	15	4	6
576	R:R:F236	R:R:L303	1.22	No	No	15	4	5
577	R:R:Q272	R:R:R275	1.17	No	No	0	3	6
578	S:S:E121	S:S:R119	1.16	No	No	0	2	4
579	S:S:L179	S:S:W182	1.14	No	Yes	10	3	7
580	S:S:L183	S:S:W182	1.14	No	Yes	10	3	7
581	R:R:L179	R:R:W182	1.14	No	Yes	14	3	7
582	R:R:L183	R:R:W182	1.14	No	Yes	14	3	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	S:S:V50	4.9325	4	1	4
2	S:S:F54	8.04	4	0	4
3	S:S:N66	4.988	5	0	9
4	S:S:L68	2.4525	4	0	5
5	S:S:V73	2.53	4	0	8
6	S:S:W94	3.4	4	0	8
7	S:S:D99	6.732	5	1	9
8	S:S:T107	8.0125	4	0	8
9	S:S:Y114	9.04	4	1	8
10	S:S:W120	5.55	6	6	5
11	S:S:D124	5.715	4	0	6
12	S:S:F133	4.982	5	6	6
13	S:S:L135	3.1525	4	0	6
14	S:S:R155	4.69	4	9	9
15	S:S:I159	2.254	5	0	8
16	S:S:M169	9.0025	4	8	5
17	S:S:W182	3.49	4	10	7
18	S:S:F188	5.474	5	3	8
19	S:S:Y199	7.936	5	3	6
20	S:S:V201	3.56	4	6	5
21	S:S:W203	8.696	5	1	4
22	S:S:T206	6.19833	6	1	8
23	S:S:W207	8.45286	7	1	7
24	S:S:C208	5.0275	4	6	9
25	S:S:N227	4.3275	4	0	5
26	S:S:F230	7.98333	6	3	6
27	S:S:F234	4.82	4	3	8
28	S:S:C248	2.21	4	0	7
29	S:S:I253	2.94	4	0	6
30	S:S:L284	6.4425	4	0	9
31	S:S:W295	7.29714	7	1	8
32	S:S:L298	3.5475	4	0	7
33	S:S:I306	6.208	5	0	5
34	S:S:F328	4.01667	6	1	6
35	S:S:L329	6.755	4	1	7
36	S:S:R333	9.505	4	1	8
37	S:S:N338	7.372	5	1	9
38	S:S:Q339	7.42167	6	1	8
39	S:S:D342	6.13	4	1	9
40	S:S:P343	4.282	5	4	9
41	S:S:W344	6.7075	4	4	8
42	S:S:Y346	4.98333	6	9	9
43	R:R:F54	8.04	4	0	4
44	R:R:N66	4.988	5	0	9
45	R:R:L68	2.558	5	0	5
46	R:R:V73	2.53	4	0	8
47	R:R:W94	2.9325	4	0	8
48	R:R:D99	7.31	4	2	9
49	R:R:T107	7.7575	4	0	8
50	R:R:Y114	9.04	4	2	8
51	R:R:W120	5.48286	7	5	5
52	R:R:D124	5.715	4	0	6
53	R:R:F133	5.23	5	5	6
54	R:R:L135	3.1525	4	0	6
55	R:R:R155	4.69	4	13	9
56	R:R:M169	9.0025	4	12	5
57	R:R:W182	3.0225	4	14	7
58	R:R:F188	5.93	4	0	8
59	R:R:Y199	6.58	6	7	6
60	R:R:V201	3.9175	4	5	5
61	R:R:Q202	6.57	4	2	8
62	R:R:W203	9.95	4	0	4
63	R:R:T206	6.6	5	2	8
64	R:R:W207	8.56571	7	2	7
65	R:R:C208	5.355	4	5	9
66	R:R:F230	7.98333	6	7	6
67	R:R:F234	4.5075	4	0	8
68	R:R:L284	6.085	4	0	9
69	R:R:L291	4.4075	4	0	9
70	R:R:W295	7.61667	6	2	8
71	R:R:I306	6.208	5	0	5
72	R:R:F328	4.225	6	2	6
73	R:R:L329	6.112	5	2	7
74	R:R:R333	9.0825	4	2	8
75	R:R:N338	7.68	5	2	9
76	R:R:Q339	7.08667	6	2	8
77	R:R:D342	6.4675	4	2	9
78	R:R:P343	4.5325	4	4	9
79	R:R:W344	6.1375	4	4	8
80	R:R:Y346	5.954	5	13	9
81	M:M:?1	8.008	15	1	0
82	L:L:?1	7.976	15	2	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	M:M:?1	S:S:R333	77.2991	5.05	Yes	Yes	1	0	8
2	S:S:F54	S:S:R333	100	17.1	Yes	Yes	0	4	8
3	S:S:L329	S:S:R333	21.884	12.15	Yes	Yes	1	7	8
4	R:R:F54	S:S:F54	99.5493	9.65	Yes	Yes	0	4	4
5	M:M:?1	S:S:Q339	23.3161	9.21	Yes	Yes	1	0	8
6	S:S:D99	S:S:Q339	18.0988	10.44	Yes	Yes	1	9	8
7	S:S:D99	S:S:N66	15.5026	5.39	Yes	Yes	0	9	9
8	S:S:N66	S:S:P343	15.7878	8.15	Yes	Yes	0	9	9
9	S:S:P343	S:S:W344	12.516	4.05	Yes	Yes	4	9	8
10	S:S:D99	S:S:L95	14.1439	5.43	Yes	No	0	9	9
11	S:S:I147	S:S:L95	13.6547	8.56	No	No	0	7	9
12	S:S:I147	S:S:L178	12.6728	4.28	No	No	0	7	7
13	M:M:?1	S:S:W295	34.3439	3.15	Yes	Yes	1	0	8
14	S:S:N338	S:S:W295	17.5422	9.04	Yes	Yes	1	9	8
15	S:S:L291	S:S:N338	33.1318	6.87	No	Yes	0	9	9
16	S:S:F246	S:S:L291	31.8246	3.65	No	No	0	5	9
17	S:S:F246	S:S:M288	28.5446	12.44	No	No	0	5	8
18	S:S:M288	S:S:N249	27.2278	7.01	No	No	0	8	9
19	S:S:L284	S:S:N249	21.441	9.61	Yes	No	0	9	9
20	S:S:N338	S:S:Q339	15.9569	7.92	Yes	Yes	1	9	8
21	S:S:F328	S:S:W207	45.0374	5.01	Yes	Yes	1	6	7
22	S:S:F328	S:S:L298	39.3878	3.65	Yes	Yes	0	6	7
23	S:S:L298	S:S:M302	63.0286	4.24	Yes	No	0	7	7
24	S:S:F234	S:S:M302	62.346	3.73	Yes	No	0	8	7
25	S:S:F188	S:S:F234	22.0325	3.22	Yes	Yes	3	8	8
26	S:S:F188	S:S:F230	17.7664	12.86	Yes	Yes	3	8	6
27	S:S:F230	S:S:Y199	19.2677	3.09	Yes	Yes	3	6	6
28	S:S:L135	S:S:Y199	24.4406	3.52	Yes	Yes	0	6	6
29	S:S:L135	S:S:V139	17.7558	2.98	Yes	No	0	6	7
30	S:S:F140	S:S:V139	11.8417	3.93	No	No	0	8	7
31	M:M:?1	S:S:W207	24.1649	11.04	Yes	Yes	1	0	7
32	S:S:L329	S:S:W207	20.5832	4.56	Yes	Yes	1	7	7
33	S:S:A335	S:S:W295	29.0533	7.78	No	Yes	0	8	8
34	S:S:A335	S:S:L298	28.7758	3.15	No	Yes	0	8	7
35	S:S:F234	S:S:I210	37.4535	5.02	Yes	No	0	8	6
36	S:S:F230	S:S:I210	17.654	8.79	Yes	No	0	6	6
37	S:S:I210	S:S:T138	19.1305	3.04	No	No	0	6	7
38	S:S:L284	S:S:T252	13.9694	2.95	Yes	No	0	9	9
39	S:S:I159	S:S:T252	13.2448	1.52	Yes	No	0	8	9
40	R:R:W344	S:S:W344	17.7268	3.75	Yes	Yes	4	8	8
41	L:L:?1	R:R:R333	87.0036	3.36	Yes	Yes	2	0	8
42	R:R:F54	R:R:R333	99.1305	17.1	Yes	Yes	0	4	8
43	R:R:L329	R:R:R333	10.3806	12.15	Yes	Yes	2	7	8
44	R:R:P343	R:R:W344	15.2554	4.05	Yes	Yes	4	9	8
45	R:R:D99	R:R:Q339	15.644	10.44	Yes	Yes	2	9	8
46	L:L:?1	R:R:Q339	46.072	8.29	Yes	Yes	2	0	8
47	R:R:I147	R:R:L178	15.2039	4.28	No	No	0	7	7
48	R:R:I147	R:R:L95	16.4402	8.56	No	No	0	7	9
49	R:R:D99	R:R:L95	17.0566	5.43	Yes	No	0	9	9
50	R:R:M288	R:R:N249	25.0611	7.01	No	No	0	8	9
51	R:R:F246	R:R:M288	26.1436	12.44	No	No	0	5	8
52	R:R:F246	R:R:L291	28.8794	3.65	No	Yes	0	5	9
53	R:R:L291	R:R:N338	34.8135	5.49	Yes	Yes	0	9	9
54	R:R:N338	R:R:Q339	32.8343	7.92	Yes	Yes	2	9	8
55	R:R:G134	R:R:Y199	25.0989	8.69	No	Yes	0	7	6
56	R:R:G134	R:R:M137	25.5603	3.49	No	No	0	7	7
57	L:L:?1	R:R:M137	34.6887	10.77	Yes	No	0	0	7
58	L:L:?1	R:R:T106	11.0278	5.1	Yes	No	0	0	6
59	R:R:F133	R:R:M137	10.3605	6.22	Yes	No	0	6	7
60	R:R:F133	R:R:W120	11.3099	4.01	Yes	Yes	5	6	5
61	R:R:F230	R:R:Y199	12.0186	3.09	Yes	Yes	7	6	6
62	R:R:L284	R:R:N249	19.4085	9.61	Yes	No	0	9	9
63	R:R:I159	R:R:T252	15.0087	1.52	No	No	0	8	9
64	R:R:L284	R:R:T252	15.6198	2.95	Yes	No	0	9	9
65	R:R:I159	R:R:P162	12.5527	1.69	No	No	0	8	9
66	R:R:F328	R:R:W207	12.2948	5.01	Yes	Yes	2	6	7
67	S:S:L135	S:S:L190	11.8417	1.38	Yes	No	0	6	6
68	R:R:N66	R:R:P343	15.3743	8.15	Yes	Yes	0	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:V50	S:S:Y114	3.79	1	Yes	Yes	4	8	2	1
S:S:V50	S:S:W203	3.68	1	Yes	Yes	4	4	2	2
S:S:P204	S:S:V50	8.84	1	No	Yes	7	4	2	2
S:S:I111	S:S:V52	4.61	0	No	No	7	5	2	2
S:S:V52	S:S:Y114	10.09	0	No	Yes	5	8	2	1
S:S:F54	S:S:R333	17.1	0	Yes	Yes	4	8	2	1
S:S:P55	S:S:V110	3.53	1	No	No	7	8	1	1
M:M:?1	S:S:P55	3.41	1	Yes	No	0	7	0	1
S:S:M58	S:S:R333	3.72	1	No	Yes	8	8	1	1
S:S:I340	S:S:M58	4.37	0	No	No	9	8	2	1
M:M:?1	S:S:M58	8.81	1	Yes	No	0	8	0	1
S:S:L59	S:S:T107	13.27	0	No	Yes	7	8	2	1
S:S:D99	S:S:S144	4.42	1	Yes	No	9	8	2	2
S:S:D99	S:S:Q339	10.44	1	Yes	Yes	9	8	2	1
S:S:D342	S:S:D99	7.98	1	Yes	Yes	9	9	2	2
S:S:F133	S:S:T106	6.49	6	Yes	No	6	6	2	1
S:S:T106	S:S:T136	3.14	0	No	No	6	5	1	2
M:M:?1	S:S:T106	5.1	1	Yes	No	0	6	0	1
S:S:P108	S:S:T107	3.5	0	No	Yes	8	8	2	1
S:S:I111	S:S:T107	3.04	0	No	Yes	7	8	2	1
M:M:?1	S:S:T107	12.24	1	Yes	Yes	0	8	0	1
S:S:T206	S:S:V110	3.17	1	Yes	No	8	8	1	1
M:M:?1	S:S:V110	6.19	1	Yes	No	0	8	0	1
S:S:T206	S:S:V113	4.76	1	Yes	No	8	7	1	2
S:S:T206	S:S:Y114	14.98	1	Yes	Yes	8	8	1	1
M:M:?1	S:S:Y114	7.3	1	Yes	Yes	0	8	0	1
S:S:F133	S:S:M137	4.98	6	Yes	No	6	7	2	1
M:M:?1	S:S:M137	9.79	1	Yes	No	0	7	0	1
S:S:Q339	S:S:S144	8.66	1	Yes	No	8	8	1	2
S:S:D342	S:S:S144	5.89	1	Yes	No	9	8	2	2
S:S:L145	S:S:W295	20.5	0	No	Yes	8	8	2	1
S:S:Q202	S:S:W207	16.43	1	No	Yes	8	7	2	1
S:S:F209	S:S:Q202	3.51	1	No	No	8	8	2	2
S:S:F328	S:S:Q202	3.51	1	Yes	No	6	8	2	2
S:S:P204	S:S:W203	20.27	1	No	Yes	7	4	2	2
S:S:L329	S:S:W203	4.56	1	Yes	Yes	7	4	1	2
S:S:P204	S:S:T206	3.5	1	No	Yes	7	8	2	1
S:S:T206	S:S:W207	3.64	1	Yes	Yes	8	7	1	1
M:M:?1	S:S:T206	7.14	1	Yes	Yes	0	8	0	1
S:S:F209	S:S:W207	5.01	1	No	Yes	8	7	2	1
S:S:F328	S:S:W207	5.01	1	Yes	Yes	6	7	2	1
S:S:L329	S:S:W207	4.56	1	Yes	Yes	7	7	1	1
S:S:V332	S:S:W207	13.48	1	No	Yes	7	7	1	1
M:M:?1	S:S:W207	11.04	1	Yes	Yes	0	7	0	1
S:S:F209	S:S:F328	3.22	1	No	Yes	8	6	2	2
S:S:L299	S:S:W295	3.42	0	No	Yes	8	8	2	1
S:S:A335	S:S:W295	7.78	0	No	Yes	8	8	2	1
S:S:N338	S:S:W295	9.04	1	Yes	Yes	9	8	2	1
S:S:Q339	S:S:W295	4.38	1	Yes	Yes	8	8	1	1
M:M:?1	S:S:W295	3.15	1	Yes	Yes	0	8	0	1
S:S:L329	S:S:R333	12.15	1	Yes	Yes	7	8	1	1
M:M:?1	S:S:L329	5.75	1	Yes	Yes	0	7	0	1
M:M:?1	S:S:V332	6.19	1	Yes	No	0	7	0	1
M:M:?1	S:S:R333	5.05	1	Yes	Yes	0	8	0	1
M:M:?1	S:S:S336	19.75	1	Yes	No	0	8	0	1
S:S:N338	S:S:Q339	7.92	1	Yes	Yes	9	8	2	1
S:S:D342	S:S:N338	6.73	1	Yes	Yes	9	9	2	2
S:S:D342	S:S:Q339	3.92	1	Yes	Yes	9	8	2	1
M:M:?1	S:S:Q339	9.21	1	Yes	Yes	0	8	0	1
S:S:G141	S:S:W295	2.81	0	No	Yes	7	8	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:L329	R:R:S49	4.5	2	Yes	No	7	4	1	2
R:R:V50	R:R:Y114	3.79	0	No	Yes	4	8	2	1
R:R:P204	R:R:V50	8.84	0	No	No	7	4	2	2
R:R:I111	R:R:V52	4.61	0	No	No	7	5	2	2
R:R:V52	R:R:Y114	10.09	0	No	Yes	5	8	2	1
R:R:F54	R:R:R333	17.1	0	Yes	Yes	4	8	2	1
R:R:P55	R:R:V110	3.53	2	No	No	7	8	1	1
L:L:?1	R:R:P55	3.41	2	Yes	No	0	7	0	1
R:R:M58	R:R:R333	3.72	2	No	Yes	8	8	1	1
R:R:I340	R:R:M58	4.37	0	No	No	9	8	2	1
L:L:?1	R:R:M58	9.79	2	Yes	No	0	8	0	1
R:R:L59	R:R:T107	13.27	0	No	Yes	7	8	2	1
R:R:G62	R:R:Q103	4.93	0	No	No	9	8	2	1
R:R:G62	R:R:I340	3.53	0	No	No	9	9	2	2
R:R:D99	R:R:N66	5.39	2	Yes	Yes	9	9	2	2
R:R:N66	R:R:Q103	3.96	0	Yes	No	9	8	2	1
R:R:D99	R:R:Q339	10.44	2	Yes	Yes	9	8	2	1
R:R:D342	R:R:D99	7.98	2	Yes	Yes	9	9	2	2
L:L:?1	R:R:Q103	5.53	2	Yes	No	0	8	0	1
R:R:F133	R:R:T106	6.49	5	Yes	No	6	6	2	1
R:R:T106	R:R:T136	3.14	0	No	No	6	5	1	2
L:L:?1	R:R:T106	5.1	2	Yes	No	0	6	0	1
R:R:P108	R:R:T107	3.5	0	No	Yes	8	8	2	1
R:R:I111	R:R:T107	3.04	0	No	Yes	7	8	2	1
L:L:?1	R:R:T107	11.22	2	Yes	Yes	0	8	0	1
L:L:?1	R:R:V110	6.19	2	Yes	No	0	8	0	1
R:R:T206	R:R:V113	4.76	2	Yes	No	8	7	1	2
R:R:T206	R:R:Y114	14.98	2	Yes	Yes	8	8	1	1
L:L:?1	R:R:Y114	7.3	2	Yes	Yes	0	8	0	1
R:R:F133	R:R:M137	6.22	5	Yes	No	6	7	2	1
R:R:G134	R:R:M137	3.49	0	No	No	7	7	2	1
L:L:?1	R:R:M137	10.77	2	Yes	No	0	7	0	1
R:R:Q339	R:R:S144	8.66	2	Yes	No	8	8	1	2
R:R:D342	R:R:S144	5.89	2	Yes	No	9	8	2	2
R:R:Q202	R:R:W207	16.43	2	Yes	Yes	8	7	2	1
R:R:F209	R:R:Q202	3.51	2	No	Yes	8	8	2	2
R:R:F328	R:R:Q202	3.51	2	Yes	Yes	6	8	2	2
R:R:P204	R:R:W203	20.27	0	No	Yes	7	4	2	2
R:R:L329	R:R:W203	4.56	2	Yes	Yes	7	4	1	2
R:R:P204	R:R:T206	3.5	0	No	Yes	7	8	2	1
R:R:T206	R:R:W207	3.64	2	Yes	Yes	8	7	1	1
L:L:?1	R:R:T206	6.12	2	Yes	Yes	0	8	0	1
R:R:F209	R:R:W207	5.01	2	No	Yes	8	7	2	1
R:R:F328	R:R:W207	5.01	2	Yes	Yes	6	7	2	1
R:R:L329	R:R:W207	4.56	2	Yes	Yes	7	7	1	1
R:R:V332	R:R:W207	13.48	2	No	Yes	7	7	1	1
L:L:?1	R:R:W207	11.83	2	Yes	Yes	0	7	0	1
R:R:F209	R:R:F328	3.22	2	No	Yes	8	6	2	2
R:R:N338	R:R:W295	9.04	2	Yes	Yes	9	8	2	2
R:R:Q339	R:R:W295	3.29	2	Yes	Yes	8	8	1	2
R:R:L329	R:R:R333	12.15	2	Yes	Yes	7	8	1	1
L:L:?1	R:R:L329	4.79	2	Yes	Yes	0	7	0	1
L:L:?1	R:R:V332	6.19	2	Yes	No	0	7	0	1
L:L:?1	R:R:R333	3.36	2	Yes	Yes	0	8	0	1
L:L:?1	R:R:S336	19.75	2	Yes	No	0	8	0	1
R:R:N338	R:R:Q339	7.92	2	Yes	Yes	9	8	2	1
R:R:D342	R:R:N338	8.08	2	Yes	Yes	9	9	2	2
R:R:D342	R:R:Q339	3.92	2	Yes	Yes	9	8	2	1
L:L:?1	R:R:Q339	8.29	2	Yes	Yes	0	8	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	6AK3_poly
Class	A
SubFamily	Lipid
Type	Prostanoid
SubType	EP3
Species	Homo sapiens
Ligand	Dinoprostone IPGE2
Other Ligand(s)	-
Protein Partners	-
PDB Resolution	2.9
Date	2018-12-05
D.O.I.	10.1038/s41589-018-0171-8

Net Summary
I_min	3.04
Number of Linked Nodes	504
Number of Links	582
Number of Hubs	82
Number of Links mediated by Hubs	318
Number of Communities	15
Number of Nodes involved in Communities	94
Number of Links involved in Communities	136

Path Summary
Number Of Nodes in MetaPath	69
Number Of Links MetaPath	68
Number of Shortest Paths	314399
Length Of Smallest Path	3
Average Path Length	16.8931
Length of Longest Path	40
Minimum Path Strength	1.38
Average Path Strength	6.49516
Maximum Path Strength	21.28
Minimum Path Correlation	0.7
Average Path Correlation	0.962687
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.57143
Average % Of Corr. Nodes	53.4748
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	56.8653
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	P2E
PDB Residues	M:M:?1 L:L:?1
Environment Details	Open EMBL-EBI Page
Code	P2E
Name	Dinoprostone
Synonyms	Dinoprostone Prostaglandin E2
Identifier	(Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxo-cyclopentyl]hept-5-enoic acid
Formula	C20 H32 O5
Molecular Weight	352.465
SMILES	CCCCC[C@@H](\C=C\[C@H]1[C@@H](CC(=O)[C@@H]1C\C=C/CCCC(=O)O)O)O
PubChem	5280360
Formal Charge	0
Total Atoms	57
Total Chiral Atoms	4
Total Bonds	57
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P43115
Sequence	>6AK3_poly_Chain_R C G S V S V A F P I T M L L T G F V G N A L A M L L V S R S R K S F L L C I G W L A L T D L V G Q L L T T P V V I V V Y L S K R W E H I D P G R L C T F F G L T M T V F G L S S L F I A S A M A V E R A L A I R A P H W Y A S H M K T R I T R A V L L G V W L A S L A F A L L P V L G V G Q Y T V Q W P G T W C F I S T G G N L F F A S A F A F L G L L A L T V T F S C N L A T I K A L V D R C R A K A A Q W G R I T T E T A I Q L M G I M L V L S V C W S P L L I M M L K M I F K E C N F F L I A V R L A S L N Q I L D P W V Y L L L R K I L L R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6AK3	A	Lipid	Prostanoid	EP₃	Homo sapiens	Dinoprostone IPGE2	-	-	2.9	2018-12-05	10.1038/s41589-018-0171-8
	6M9T	A	Lipid	Prostanoid	EP₃	Homo sapiens	Misoprostol-FA	-	-	2.5	2018-12-05	10.1038/s41589-018-0160-y
	7WU9	A	Lipid	Prostanoid	EP₃	Homo sapiens	-	-	Gi1/&β;1/&γ;2	3.38	2022-08-17	10.1016/j.celrep.2022.111323
	8GDC	A	Lipid	Prostanoid	EP₃	Homo sapiens	PGE2	-	Gi1/&β;1/&γ;2	3.5	2024-01-03	10.1073/pnas.2216329120
	6AK3 (Dimer)	A	Lipid	Prostanoid	EP₃	Homo sapiens	Dinoprostone IPGE2	-	-	2.9	2018-12-05	10.1038/s41589-018-0171-8

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Download 6AK3_poly.zip

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