psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:P55	3.68	Yes	No	2	0	7
2	L:L:?1	R:R:M58	10.57	Yes	No	2	0	8
3	L:L:?1	R:R:Q103	5.97	Yes	No	0	0	8
4	L:L:?1	R:R:T106	5.51	Yes	No	0	0	6
5	L:L:?1	R:R:T107	12.12	Yes	Yes	0	0	8
6	L:L:?1	R:R:V110	6.68	Yes	No	2	0	8
7	L:L:?1	R:R:Y114	7.89	Yes	Yes	2	0	8
8	L:L:?1	R:R:M137	11.63	Yes	No	0	0	7
9	L:L:?1	R:R:T206	6.61	Yes	Yes	2	0	8
10	L:L:?1	R:R:W207	12.78	Yes	Yes	2	0	7
11	L:L:?1	R:R:L329	5.18	Yes	Yes	2	0	7
12	L:L:?1	R:R:V332	6.68	Yes	No	2	0	7
13	L:L:?1	R:R:R333	3.63	Yes	Yes	2	0	8
14	L:L:?1	R:R:S336	21.33	Yes	No	0	0	8
15	L:L:?1	R:R:Q339	8.96	Yes	Yes	2	0	8
16	M:M:?1	S:S:P55	3.68	Yes	No	1	0	7
17	M:M:?1	S:S:M58	9.51	Yes	No	1	0	8
18	M:M:?1	S:S:T106	5.51	Yes	No	0	0	6
19	M:M:?1	S:S:T107	13.23	Yes	Yes	0	0	8
20	M:M:?1	S:S:V110	6.68	Yes	No	1	0	8
21	M:M:?1	S:S:Y114	7.89	Yes	Yes	1	0	8
22	M:M:?1	S:S:M137	10.57	Yes	No	0	0	7
23	M:M:?1	S:S:T206	7.72	Yes	Yes	1	0	8
24	M:M:?1	S:S:W207	11.92	Yes	Yes	1	0	7
25	M:M:?1	S:S:W295	3.41	Yes	Yes	1	0	8
26	M:M:?1	S:S:L329	6.21	Yes	Yes	1	0	7
27	M:M:?1	S:S:V332	6.68	Yes	No	1	0	7
28	M:M:?1	S:S:R333	5.45	Yes	Yes	1	0	8
29	M:M:?1	S:S:S336	21.33	Yes	No	0	0	8
30	M:M:?1	S:S:Q339	9.95	Yes	Yes	1	0	8
31	R:R:C47	R:R:V50	3.42	No	No	0	5	4
32	R:R:N326	R:R:S49	4.47	No	No	0	1	4
33	R:R:L329	R:R:S49	4.5	Yes	No	0	7	4
34	R:R:V50	R:R:Y114	3.79	No	Yes	0	4	8
35	R:R:P204	R:R:V50	8.84	No	No	0	7	4
36	R:R:I56	R:R:V52	6.14	No	No	0	4	5
37	R:R:I111	R:R:V52	4.61	No	No	0	7	5
38	R:R:V52	R:R:Y114	10.09	No	Yes	0	5	8
39	R:R:F54	R:R:R333	17.1	Yes	Yes	0	4	8
40	R:R:F54	S:S:F54	9.65	Yes	Yes	0	4	4
41	R:R:P55	R:R:V110	3.53	No	No	2	7	8
42	R:R:M58	R:R:R333	3.72	No	Yes	2	8	8
43	R:R:I340	R:R:M58	4.37	No	No	0	9	8
44	R:R:L59	R:R:T107	13.27	No	Yes	0	7	8
45	R:R:I340	R:R:T61	4.56	No	No	0	9	6
46	R:R:G62	R:R:Q103	4.93	No	No	0	9	8
47	R:R:G62	R:R:I340	3.53	No	No	0	9	9
48	R:R:F63	R:R:L100	6.09	No	No	0	7	7
49	R:R:G65	R:R:P343	4.06	No	Yes	3	9	9
50	R:R:G65	R:R:W344	4.22	No	Yes	3	9	8
51	R:R:A96	R:R:N66	4.69	No	Yes	0	9	9
52	R:R:D99	R:R:N66	5.39	Yes	Yes	0	9	9
53	R:R:N66	R:R:Q103	3.96	Yes	No	0	9	8
54	R:R:N66	R:R:P343	8.15	Yes	Yes	0	9	9
55	R:R:L68	S:S:I352	4.28	Yes	No	0	5	6
56	R:R:L97	R:R:M70	4.24	No	No	0	6	7
57	R:R:L347	R:R:L72	4.15	No	No	0	9	8
58	R:R:K351	R:R:L72	5.64	No	No	0	5	8
59	R:R:G93	R:R:V73	5.52	No	Yes	0	6	8
60	R:R:R75	S:S:R355	4.26	No	No	0	5	5
61	R:R:L90	R:R:R78	15.79	No	No	0	6	4
62	R:R:R175	R:R:R78	7.46	No	No	0	5	4
63	R:R:M169	R:R:S87	6.13	Yes	No	0	5	6
64	R:R:S87	R:R:T174	4.8	No	No	0	6	6
65	R:R:E154	R:R:F88	3.5	No	No	0	8	8
66	R:R:C91	R:R:M151	6.48	No	No	0	7	9
67	R:R:I92	R:R:Y346	3.63	No	Yes	0	8	9
68	R:R:L178	R:R:W94	3.42	No	Yes	0	7	8
69	R:R:W182	R:R:W94	3.75	Yes	Yes	0	7	8
70	R:R:D99	R:R:L95	5.43	Yes	No	0	9	9
71	R:R:I147	R:R:L95	8.56	No	No	0	7	9
72	R:R:T98	R:R:W182	6.06	No	Yes	0	9	7
73	R:R:D99	R:R:Q339	10.44	Yes	Yes	2	9	8
74	R:R:D342	R:R:D99	7.98	Yes	Yes	2	9	9
75	R:R:L100	R:R:L104	8.3	No	No	0	7	5
76	R:R:F140	R:R:V101	5.24	No	No	0	8	5
77	R:R:F140	R:R:G102	10.54	No	No	0	8	8
78	R:R:F133	R:R:T106	6.49	Yes	No	0	6	6
79	R:R:T106	R:R:T136	3.14	No	No	0	6	5
80	R:R:P108	R:R:T107	3.5	No	Yes	0	8	8
81	R:R:I111	R:R:T107	3.04	No	Yes	0	7	8
82	R:R:V109	R:R:W120	3.68	No	Yes	5	6	5
83	R:R:F133	R:R:V109	5.24	Yes	No	5	6	6
84	R:R:V113	R:R:W120	3.68	No	Yes	0	7	5
85	R:R:T206	R:R:V113	4.76	Yes	No	0	8	7
86	R:R:T206	R:R:Y114	14.98	Yes	Yes	2	8	8
87	R:R:I123	R:R:S116	4.64	No	No	0	3	4
88	R:R:H122	R:R:R119	11.28	No	No	0	3	4
89	R:R:D124	R:R:W120	7.82	Yes	Yes	0	6	5
90	R:R:C130	R:R:W120	6.53	No	Yes	5	9	5
91	R:R:F133	R:R:W120	4.01	Yes	Yes	5	6	5
92	R:R:V201	R:R:W120	6.13	Yes	Yes	5	5	5
93	R:R:C208	R:R:W120	6.53	Yes	Yes	5	9	5
94	R:R:E121	R:R:V201	4.28	No	Yes	0	2	5
95	R:R:D124	R:R:P125	3.22	Yes	No	0	6	4
96	R:R:D124	R:R:G127	5.03	Yes	No	0	6	3
97	R:R:D124	R:R:L129	6.79	Yes	No	0	6	5
98	R:R:C130	R:R:C208	7.28	No	Yes	5	9	9
99	R:R:F132	R:R:T136	7.78	No	No	0	4	5
100	R:R:F133	R:R:M137	6.22	Yes	No	0	6	7
101	R:R:C208	R:R:F133	4.19	Yes	Yes	5	9	6
102	R:R:G134	R:R:M137	3.49	No	No	0	7	7
103	R:R:G134	R:R:Y199	8.69	No	Yes	0	7	6
104	R:R:A189	R:R:L135	4.73	No	Yes	0	8	6
105	R:R:L135	R:R:Y199	3.52	Yes	Yes	0	6	6
106	R:R:A189	R:R:T138	3.36	No	No	0	8	7
107	R:R:T138	R:R:Y199	6.24	No	Yes	0	7	6
108	R:R:I210	R:R:T138	3.04	No	No	0	6	7
109	R:R:F140	R:R:V139	3.93	No	No	0	8	7
110	R:R:F234	R:R:L142	7.31	Yes	No	0	8	7
111	R:R:S143	R:R:S185	3.26	No	No	0	7	7
112	R:R:Q339	R:R:S144	8.66	Yes	No	2	8	8
113	R:R:D342	R:R:S144	5.89	Yes	No	2	9	8
114	R:R:L145	R:R:W295	19.36	No	Yes	0	8	8
115	R:R:F146	R:R:L237	3.65	No	No	0	6	5
116	R:R:A241	R:R:F146	8.32	No	No	0	7	6
117	R:R:I147	R:R:L178	4.28	No	No	0	7	7
118	R:R:I147	R:R:V181	3.07	No	No	0	7	6
119	R:R:S149	R:R:V244	4.85	No	No	0	6	5
120	R:R:S149	R:R:T245	4.8	No	No	0	6	9
121	R:R:M151	R:R:Y346	8.38	No	Yes	0	9	9
122	R:R:A152	R:R:T245	5.03	No	No	0	9	9
123	R:R:E154	R:R:Y165	6.73	No	No	8	8	8
124	R:R:E154	R:R:M169	5.41	No	Yes	8	8	5
125	R:R:Q283	R:R:R155	5.84	No	Yes	0	8	9
126	R:R:L284	R:R:R155	6.07	Yes	Yes	0	9	9
127	R:R:I287	R:R:R155	3.76	No	Yes	9	8	9
128	R:R:R155	R:R:Y346	3.09	Yes	Yes	9	9	9
129	R:R:A158	R:R:Y165	8.01	No	No	0	9	8
130	R:R:A251	R:R:R160	4.15	No	No	0	5	7
131	R:R:A255	R:R:R160	6.91	No	No	0	7	7
132	R:R:A161	R:R:H163	4.39	No	No	0	4	6
133	R:R:H163	R:R:P162	3.05	No	No	0	6	9
134	R:R:P162	R:R:R259	4.32	No	No	0	9	7
135	R:R:H168	R:R:W164	29.62	No	No	0	3	4
136	R:R:M169	R:R:Y165	15.57	Yes	No	8	5	8
137	R:R:K170	R:R:R172	11.14	No	No	0	6	5
138	R:R:R175	R:R:T171	5.17	No	No	0	5	4
139	R:R:F188	R:R:F230	12.86	Yes	Yes	0	8	6
140	R:R:F188	R:R:F234	3.22	Yes	Yes	0	8	8
141	R:R:F188	R:R:L237	4.87	Yes	No	0	8	5
142	R:R:L191	R:R:V196	5.96	No	No	0	7	4
143	R:R:F230	R:R:L191	8.53	Yes	No	0	6	7
144	R:R:G197	R:R:P192	4.06	No	No	7	7	9
145	R:R:P192	R:R:Y199	16.69	No	Yes	7	9	6
146	R:R:F230	R:R:P192	10.11	Yes	No	7	6	9
147	R:R:F230	R:R:G197	4.52	Yes	No	7	6	7
148	R:R:N227	R:R:Q198	9.24	No	No	0	5	2
149	R:R:F230	R:R:Y199	3.09	Yes	Yes	7	6	6
150	R:R:S211	R:R:T200	6.4	No	No	0	5	4
151	R:R:C208	R:R:V201	3.42	Yes	Yes	5	9	5
152	R:R:Q202	R:R:W207	16.43	Yes	Yes	2	8	7
153	R:R:F209	R:R:Q202	3.51	No	Yes	2	8	8
154	R:R:F328	R:R:Q202	3.51	Yes	Yes	2	6	8
155	R:R:P204	R:R:W203	20.27	No	Yes	0	7	4
156	R:R:C325	R:R:W203	10.45	No	Yes	0	3	4
157	R:R:N326	R:R:W203	4.52	No	Yes	0	1	4
158	R:R:L329	R:R:W203	4.56	Yes	Yes	0	7	4
159	R:R:P204	R:R:T206	3.5	No	Yes	0	7	8
160	R:R:T206	R:R:W207	3.64	Yes	Yes	2	8	7
161	R:R:F209	R:R:W207	5.01	No	Yes	2	8	7
162	R:R:F328	R:R:W207	5.01	Yes	Yes	2	6	7
163	R:R:L329	R:R:W207	4.56	Yes	Yes	2	7	7
164	R:R:V332	R:R:W207	13.48	No	Yes	2	7	7
165	R:R:F209	R:R:F328	3.22	No	Yes	2	8	6
166	R:R:F230	R:R:I210	8.79	Yes	No	0	6	6
167	R:R:F234	R:R:I210	3.77	Yes	No	0	8	6
168	R:R:M305	R:R:T212	10.54	No	No	0	6	6
169	R:R:I306	R:R:T212	3.04	Yes	No	0	5	6
170	R:R:I306	R:R:L228	5.71	Yes	No	0	5	4
171	R:R:A231	R:R:I306	3.25	No	Yes	0	6	5
172	R:R:I306	R:R:S232	7.74	Yes	No	0	5	4
173	R:R:F234	R:R:M302	3.73	Yes	No	0	8	7
174	R:R:A235	R:R:L303	3.15	No	No	0	8	5
175	R:R:G238	R:R:L299	3.42	No	No	0	7	8
176	R:R:L239	R:R:L299	4.15	No	No	0	6	8
177	R:R:L242	R:R:L291	5.54	No	Yes	0	8	9
178	R:R:F246	R:R:M288	12.44	No	No	0	5	8
179	R:R:F246	R:R:L291	3.65	No	Yes	0	5	9
180	R:R:L284	R:R:N249	9.61	Yes	No	0	9	9
181	R:R:I287	R:R:N249	4.25	No	No	0	8	9
182	R:R:M288	R:R:N249	7.01	No	No	0	8	9
183	R:R:L250	R:R:M288	7.07	No	No	0	4	8
184	R:R:I253	R:R:L284	5.71	No	Yes	0	6	9
185	R:R:D258	R:R:K254	8.3	No	No	0	4	3
186	R:R:L256	R:R:T277	8.84	No	No	0	8	8
187	R:R:L256	R:R:T280	4.42	No	No	0	8	8
188	R:R:R261	R:R:V257	7.85	No	No	0	4	5
189	R:R:C260	R:R:K263	3.23	No	No	0	5	4
190	R:R:C260	R:R:T277	8.45	No	No	0	5	8
191	R:R:A264	R:R:K263	3.21	No	No	0	3	4
192	R:R:K263	R:R:W273	19.73	No	No	0	4	4
193	R:R:E279	R:R:R275	8.14	No	No	0	7	6
194	R:R:Q283	R:R:R350	17.52	No	No	0	8	8
195	R:R:I287	R:R:Y346	10.88	No	Yes	9	8	9
196	R:R:L341	R:R:V290	4.47	No	No	0	7	8
197	R:R:L291	R:R:N338	5.49	Yes	Yes	0	9	9
198	R:R:C294	R:R:L337	4.76	No	No	0	8	4
199	R:R:C294	R:R:N338	7.87	No	Yes	0	8	9
200	R:R:L299	R:R:W295	3.42	No	Yes	0	8	8
201	R:R:A335	R:R:W295	7.78	No	Yes	0	8	8
202	R:R:N338	R:R:W295	9.04	Yes	Yes	2	9	8
203	R:R:Q339	R:R:W295	3.29	Yes	Yes	2	8	8
204	R:R:F328	R:R:L298	3.65	Yes	No	0	6	7
205	R:R:A331	R:R:L298	3.15	No	No	0	7	7
206	R:R:A335	R:R:L298	3.15	No	No	0	8	7
207	R:R:F328	R:R:M301	4.98	Yes	No	0	6	5
208	R:R:F328	R:R:M305	4.98	Yes	No	0	6	6
209	R:R:F307	R:R:I306	11.3	No	Yes	0	3	5
210	R:R:F327	R:R:K323	3.72	No	No	0	3	1
211	R:R:C325	R:R:E324	9.12	No	No	0	3	3
212	R:R:L329	R:R:R333	12.15	Yes	Yes	2	7	8
213	R:R:L337	R:R:L341	4.15	No	No	0	4	7
214	R:R:N338	R:R:Q339	7.92	Yes	Yes	2	9	8
215	R:R:D342	R:R:N338	8.08	Yes	Yes	2	9	9
216	R:R:D342	R:R:Q339	3.92	Yes	Yes	2	9	8
217	R:R:P343	R:R:W344	4.05	Yes	Yes	3	9	8
218	R:R:L348	R:R:W344	12.53	No	Yes	0	8	8
219	R:R:W344	S:S:W344	3.75	Yes	Yes	3	8	8
220	R:R:V345	R:R:Y346	3.79	No	Yes	0	8	9
221	R:R:I352	S:S:L68	4.28	No	Yes	0	6	5
222	R:R:I352	S:S:I352	5.89	No	No	0	6	6
223	R:R:R355	S:S:R75	3.2	No	No	0	5	5
224	S:S:C47	S:S:V50	3.42	No	Yes	0	5	4
225	S:S:N326	S:S:S49	4.47	No	No	0	1	4
226	S:S:V50	S:S:Y114	3.79	Yes	Yes	1	4	8
227	S:S:V50	S:S:W203	3.68	Yes	Yes	1	4	4
228	S:S:P204	S:S:V50	8.84	No	Yes	1	7	4
229	S:S:I56	S:S:V52	4.61	No	No	0	4	5
230	S:S:I111	S:S:V52	4.61	No	No	0	7	5
231	S:S:V52	S:S:Y114	10.09	No	Yes	0	5	8
232	S:S:F54	S:S:R333	17.1	Yes	Yes	0	4	8
233	S:S:P55	S:S:V110	3.53	No	No	1	7	8
234	S:S:M58	S:S:R333	3.72	No	Yes	1	8	8
235	S:S:I340	S:S:M58	4.37	No	No	0	9	8
236	S:S:L59	S:S:T107	13.27	No	Yes	0	7	8
237	S:S:I340	S:S:T61	4.56	No	No	0	9	6
238	S:S:G62	S:S:Q103	4.93	No	No	0	9	8
239	S:S:G62	S:S:I340	3.53	No	No	0	9	9
240	S:S:F63	S:S:L100	8.53	No	No	0	7	7
241	S:S:G65	S:S:P343	4.06	No	Yes	3	9	9
242	S:S:G65	S:S:W344	4.22	No	Yes	3	9	8
243	S:S:A96	S:S:N66	4.69	No	Yes	0	9	9
244	S:S:D99	S:S:N66	5.39	Yes	Yes	0	9	9
245	S:S:N66	S:S:Q103	3.96	Yes	No	0	9	8
246	S:S:N66	S:S:P343	8.15	Yes	Yes	0	9	9
247	S:S:L97	S:S:M70	4.24	No	No	0	6	7
248	S:S:L347	S:S:L72	4.15	No	No	0	9	8
249	S:S:K351	S:S:L72	4.23	No	No	0	5	8
250	S:S:G93	S:S:V73	5.52	No	Yes	0	6	8
251	S:S:R75	S:S:S76	3.95	No	No	0	5	7
252	S:S:L90	S:S:R78	14.58	No	No	0	6	4
253	S:S:R175	S:S:R78	7.46	No	No	0	5	4
254	S:S:M169	S:S:S87	6.13	Yes	No	0	5	6
255	S:S:S87	S:S:T174	3.2	No	No	0	6	6
256	S:S:C91	S:S:M151	6.48	No	No	0	7	9
257	S:S:I92	S:S:Y346	3.63	No	Yes	0	8	9
258	S:S:L178	S:S:W94	3.42	No	Yes	0	7	8
259	S:S:W182	S:S:W94	5.62	Yes	Yes	0	7	8
260	S:S:D99	S:S:L95	5.43	Yes	No	0	9	9
261	S:S:I147	S:S:L95	8.56	No	No	0	7	9
262	S:S:T98	S:S:W182	6.06	No	Yes	0	9	7
263	S:S:D99	S:S:S144	4.42	Yes	No	1	9	8
264	S:S:D99	S:S:Q339	10.44	Yes	Yes	1	9	8
265	S:S:D342	S:S:D99	7.98	Yes	Yes	1	9	9
266	S:S:L100	S:S:L104	6.92	No	No	0	7	5
267	S:S:F140	S:S:V101	5.24	No	No	0	8	5
268	S:S:F140	S:S:G102	10.54	No	No	0	8	8
269	S:S:F133	S:S:T106	6.49	Yes	No	0	6	6
270	S:S:T106	S:S:T136	3.14	No	No	0	6	5
271	S:S:P108	S:S:T107	3.5	No	Yes	0	8	8
272	S:S:I111	S:S:T107	3.04	No	Yes	0	7	8
273	S:S:L129	S:S:V109	4.47	No	No	0	5	6
274	S:S:F133	S:S:V109	5.24	Yes	No	0	6	6
275	S:S:T206	S:S:V110	3.17	Yes	No	1	8	8
276	S:S:V113	S:S:W120	4.9	No	Yes	0	7	5
277	S:S:T206	S:S:V113	4.76	Yes	No	0	8	7
278	S:S:T206	S:S:Y114	14.98	Yes	Yes	1	8	8
279	S:S:I123	S:S:S116	4.64	No	No	0	3	4
280	S:S:H122	S:S:R119	10.16	No	No	0	3	4
281	S:S:D124	S:S:W120	7.82	Yes	Yes	0	6	5
282	S:S:C130	S:S:W120	5.22	No	Yes	6	9	5
283	S:S:F133	S:S:W120	4.01	Yes	Yes	6	6	5
284	S:S:V201	S:S:W120	6.13	Yes	Yes	6	5	5
285	S:S:C208	S:S:W120	5.22	Yes	Yes	6	9	5
286	S:S:D124	S:S:P125	3.22	Yes	No	0	6	4
287	S:S:D124	S:S:G127	5.03	Yes	No	0	6	3
288	S:S:D124	S:S:L129	6.79	Yes	No	0	6	5
289	S:S:C130	S:S:C208	7.28	No	Yes	6	9	9
290	S:S:F132	S:S:T136	7.78	No	No	0	4	5
291	S:S:F133	S:S:M137	4.98	Yes	No	0	6	7
292	S:S:C208	S:S:F133	4.19	Yes	Yes	6	9	6
293	S:S:G134	S:S:Y199	10.14	No	Yes	0	7	6
294	S:S:A189	S:S:L135	4.73	No	Yes	0	8	6
295	S:S:L135	S:S:Y199	3.52	Yes	Yes	0	6	6
296	S:S:A189	S:S:T138	3.36	No	No	0	8	7
297	S:S:T138	S:S:Y199	6.24	No	Yes	0	7	6
298	S:S:I210	S:S:T138	3.04	No	No	0	6	7
299	S:S:F140	S:S:V139	3.93	No	No	0	8	7
300	S:S:L142	S:S:S185	6.01	No	No	0	7	7
301	S:S:F188	S:S:L142	3.65	Yes	No	4	8	7
302	S:S:F234	S:S:L142	7.31	Yes	No	4	8	7
303	S:S:S143	S:S:S185	3.26	No	No	0	7	7
304	S:S:Q339	S:S:S144	8.66	Yes	No	1	8	8
305	S:S:D342	S:S:S144	5.89	Yes	No	1	9	8
306	S:S:L145	S:S:W295	20.5	No	Yes	0	8	8
307	S:S:F146	S:S:L237	3.65	No	No	0	6	5
308	S:S:A241	S:S:F146	8.32	No	No	0	7	6
309	S:S:I147	S:S:L178	4.28	No	No	0	7	7
310	S:S:I147	S:S:V181	3.07	No	No	0	7	6
311	S:S:S149	S:S:V244	4.85	No	No	0	6	5
312	S:S:S149	S:S:T245	4.8	No	No	0	6	9
313	S:S:M151	S:S:Y346	7.18	No	Yes	0	9	9
314	S:S:A152	S:S:C248	3.61	No	Yes	0	9	7
315	S:S:E154	S:S:Y165	5.61	No	No	12	8	8
316	S:S:E154	S:S:M169	5.41	No	Yes	12	8	5
317	S:S:Q283	S:S:R155	5.84	No	Yes	0	8	9
318	S:S:L284	S:S:R155	6.07	Yes	Yes	0	9	9
319	S:S:I287	S:S:R155	3.76	No	Yes	13	8	9
320	S:S:R155	S:S:Y346	3.09	Yes	Yes	13	9	9
321	S:S:A158	S:S:Y165	4	No	No	0	9	8
322	S:S:I159	S:S:R259	7.52	Yes	No	0	8	7
323	S:S:A161	S:S:H163	4.39	No	No	0	4	6
324	S:S:H163	S:S:P162	3.05	No	No	0	6	9
325	S:S:H168	S:S:W164	32.8	No	No	0	3	4
326	S:S:M169	S:S:Y165	21.55	Yes	No	12	5	8
327	S:S:H168	S:S:S167	5.58	No	No	0	3	4
328	S:S:R175	S:S:T171	5.17	No	No	0	5	4
329	S:S:I173	S:S:R172	7.52	No	No	0	5	5
330	S:S:F188	S:S:F230	12.86	Yes	Yes	4	8	6
331	S:S:F188	S:S:F234	3.22	Yes	Yes	4	8	8
332	S:S:F188	S:S:L237	4.87	Yes	No	0	8	5
333	S:S:L191	S:S:V196	5.96	No	No	0	7	4
334	S:S:F230	S:S:L191	8.53	Yes	No	0	6	7
335	S:S:G197	S:S:P192	4.06	No	No	4	7	9
336	S:S:P192	S:S:Y199	16.69	No	Yes	4	9	6
337	S:S:F230	S:S:P192	10.11	Yes	No	4	6	9
338	S:S:G197	S:S:N227	3.39	No	Yes	0	7	5
339	S:S:F230	S:S:G197	4.52	Yes	No	4	6	7
340	S:S:N227	S:S:Q198	9.24	Yes	No	0	5	2
341	S:S:F230	S:S:Y199	3.09	Yes	Yes	4	6	6
342	S:S:S211	S:S:T200	6.4	No	No	0	5	4
343	S:S:C208	S:S:V201	3.42	Yes	Yes	6	9	5
344	S:S:Q202	S:S:W207	16.43	No	Yes	1	8	7
345	S:S:F209	S:S:Q202	3.51	No	No	1	8	8
346	S:S:F328	S:S:Q202	3.51	Yes	No	1	6	8
347	S:S:P204	S:S:W203	20.27	No	Yes	1	7	4
348	S:S:C325	S:S:W203	10.45	No	Yes	0	3	4
349	S:S:N326	S:S:W203	4.52	No	Yes	0	1	4
350	S:S:L329	S:S:W203	4.56	Yes	Yes	1	7	4
351	S:S:P204	S:S:T206	3.5	No	Yes	1	7	8
352	S:S:T206	S:S:W207	3.64	Yes	Yes	1	8	7
353	S:S:F209	S:S:W207	5.01	No	Yes	1	8	7
354	S:S:F328	S:S:W207	5.01	Yes	Yes	1	6	7
355	S:S:L329	S:S:W207	4.56	Yes	Yes	1	7	7
356	S:S:V332	S:S:W207	13.48	No	Yes	1	7	7
357	S:S:F209	S:S:F328	3.22	No	Yes	1	8	6
358	S:S:F230	S:S:I210	8.79	Yes	No	0	6	6
359	S:S:F234	S:S:I210	5.02	Yes	No	0	8	6
360	S:S:M305	S:S:T212	10.54	No	No	0	6	6
361	S:S:I306	S:S:T212	3.04	Yes	No	0	5	6
362	S:S:I306	S:S:L228	5.71	Yes	No	0	5	4
363	S:S:A231	S:S:I306	3.25	No	Yes	0	6	5
364	S:S:I306	S:S:S232	7.74	Yes	No	0	5	4
365	S:S:F234	S:S:M302	3.73	Yes	No	0	8	7
366	S:S:A235	S:S:L303	3.15	No	No	0	8	5
367	S:S:G238	S:S:L299	3.42	No	No	0	7	8
368	S:S:L239	S:S:L299	4.15	No	No	0	6	8
369	S:S:L242	S:S:L291	5.54	No	No	0	8	9
370	S:S:N249	S:S:T245	4.39	No	No	0	9	9
371	S:S:F246	S:S:M288	12.44	No	No	0	5	8
372	S:S:F246	S:S:L291	3.65	No	No	0	5	9
373	S:S:F246	S:S:S292	3.96	No	No	0	5	6
374	S:S:L284	S:S:N249	9.61	Yes	No	0	9	9
375	S:S:M288	S:S:N249	7.01	No	No	0	8	9
376	S:S:L250	S:S:M288	7.07	No	No	0	4	8
377	S:S:I253	S:S:L284	7.14	Yes	Yes	0	6	9
378	S:S:D258	S:S:K254	8.3	No	No	0	4	3
379	S:S:L256	S:S:T277	8.84	No	No	0	8	8
380	S:S:L256	S:S:T280	4.42	No	No	0	8	8
381	S:S:R261	S:S:V257	7.85	No	No	0	4	5
382	S:S:C260	S:S:K263	4.85	No	No	0	5	4
383	S:S:C260	S:S:T277	8.45	No	No	0	5	8
384	S:S:K263	S:S:W273	19.73	No	No	0	4	4
385	S:S:G274	S:S:K263	3.49	No	No	0	5	4
386	S:S:E279	S:S:R275	4.65	No	No	0	7	6
387	S:S:Q283	S:S:R350	18.69	No	No	0	8	8
388	S:S:I287	S:S:Y346	10.88	No	Yes	13	8	9
389	S:S:L341	S:S:V290	5.96	No	No	0	7	8
390	S:S:L291	S:S:N338	6.87	No	Yes	0	9	9
391	S:S:C294	S:S:L337	4.76	No	No	0	8	4
392	S:S:C294	S:S:N338	6.3	No	Yes	0	8	9
393	S:S:L299	S:S:W295	3.42	No	Yes	0	8	8
394	S:S:A335	S:S:W295	7.78	No	Yes	0	8	8
395	S:S:N338	S:S:W295	9.04	Yes	Yes	1	9	8
396	S:S:Q339	S:S:W295	4.38	Yes	Yes	1	8	8
397	S:S:L298	S:S:M302	4.24	Yes	No	0	7	7
398	S:S:F328	S:S:L298	3.65	Yes	Yes	0	6	7
399	S:S:A331	S:S:L298	3.15	No	Yes	0	7	7
400	S:S:A335	S:S:L298	3.15	No	Yes	0	8	7
401	S:S:F328	S:S:M301	3.73	Yes	No	0	6	5
402	S:S:E324	S:S:M305	8.12	No	No	0	3	6
403	S:S:F328	S:S:M305	4.98	Yes	No	0	6	6
404	S:S:F307	S:S:I306	11.3	No	Yes	0	3	5
405	S:S:F327	S:S:K323	4.96	No	No	0	3	1
406	S:S:L329	S:S:R333	12.15	Yes	Yes	1	7	8
407	S:S:L337	S:S:L341	4.15	No	No	0	4	7
408	S:S:N338	S:S:Q339	7.92	Yes	Yes	1	9	8
409	S:S:D342	S:S:N338	6.73	Yes	Yes	1	9	9
410	S:S:D342	S:S:Q339	3.92	Yes	Yes	1	9	8
411	S:S:P343	S:S:W344	4.05	Yes	Yes	3	9	8
412	S:S:L348	S:S:P343	3.28	No	Yes	3	8	9
413	S:S:L348	S:S:W344	14.81	No	Yes	3	8	8
414	S:S:V345	S:S:Y346	3.79	No	Yes	0	8	9
415	R:R:L89	R:R:S76	3	No	No	0	8	7
416	R:R:L142	R:R:S185	3	No	No	0	7	7
417	R:R:R259	R:R:W273	3	No	No	0	7	4
418	R:R:L68	R:R:V64	2.98	Yes	No	0	5	4
419	R:R:L105	R:R:V101	2.98	No	No	0	6	5
420	R:R:L135	R:R:V139	2.98	Yes	No	0	6	7
421	R:R:L186	R:R:V139	2.98	No	No	0	4	7
422	R:R:L157	R:R:V153	2.98	No	No	0	6	6
423	R:R:L240	R:R:V244	2.98	No	No	0	2	5
424	R:R:L289	R:R:V293	2.98	No	No	0	4	6
425	S:S:L105	S:S:V101	2.98	No	No	0	6	5
426	S:S:L135	S:S:V139	2.98	Yes	No	0	6	7
427	S:S:L157	S:S:V153	2.98	No	No	0	6	6
428	S:S:L194	S:S:V193	2.98	No	No	0	4	4
429	S:S:N227	S:S:S211	2.98	Yes	No	0	5	5
430	S:S:L289	S:S:V293	2.98	No	No	0	4	6
431	R:R:L178	R:R:T174	2.95	No	No	0	7	6
432	R:R:L291	R:R:T245	2.95	Yes	No	0	9	9
433	R:R:L284	R:R:T252	2.95	Yes	No	0	9	9
434	S:S:L178	S:S:T174	2.95	No	No	0	7	6
435	S:S:L284	S:S:T252	2.95	Yes	No	0	9	9
436	R:R:I173	R:R:M169	2.92	No	Yes	0	5	5
437	S:S:I173	S:S:M169	2.92	No	Yes	0	5	5
438	R:R:I300	R:R:K304	2.91	No	No	0	7	3
439	R:R:I92	R:R:L347	2.85	No	No	0	8	9
440	R:R:I111	R:R:L115	2.85	No	No	0	7	4
441	R:R:I330	R:R:L334	2.85	No	No	0	4	6
442	S:S:I92	S:S:L347	2.85	No	No	0	8	9
443	S:S:I111	S:S:L115	2.85	No	No	0	7	4
444	S:S:E121	S:S:V201	2.85	No	Yes	0	2	5
445	S:S:I330	S:S:L334	2.85	No	No	0	4	6
446	R:R:Q202	R:R:T200	2.83	Yes	No	0	8	4
447	R:R:I330	R:R:N326	2.83	No	No	0	4	1
448	S:S:I330	S:S:N326	2.83	No	No	0	4	1
449	R:R:K351	R:R:L354	2.82	No	No	0	5	7
450	S:S:K351	S:S:L354	2.82	No	No	0	5	7
451	R:R:G141	R:R:W295	2.81	No	Yes	0	7	8
452	S:S:G141	S:S:W295	2.81	No	Yes	0	7	8
453	R:R:H168	R:R:S167	2.79	No	No	0	3	4
454	R:R:A53	S:S:F54	2.77	No	Yes	0	4	4
455	R:R:F54	S:S:A53	2.77	Yes	No	0	4	4
456	R:R:L348	R:R:L68	2.77	No	Yes	0	8	5
457	R:R:L179	R:R:L183	2.77	No	No	10	3	3
458	R:R:A233	R:R:F188	2.77	No	Yes	0	5	8
459	S:S:L348	S:S:L68	2.77	No	Yes	0	8	5
460	S:S:L179	S:S:L183	2.77	No	No	14	3	3
461	S:S:A233	S:S:F188	2.77	No	Yes	0	5	8
462	R:R:L100	R:R:N66	2.75	No	Yes	0	7	9
463	S:S:L100	S:S:N66	2.75	No	Yes	0	7	9
464	R:R:F54	R:R:S51	2.64	Yes	No	0	4	7
465	R:R:R75	R:R:S76	2.64	No	No	0	5	7
466	R:R:F246	R:R:S292	2.64	No	No	0	5	6
467	S:S:F54	S:S:S51	2.64	Yes	No	0	4	7
468	R:R:F229	R:R:V196	2.62	No	No	0	4	4
469	S:S:F229	S:S:V196	2.62	No	No	0	4	4
470	R:R:I173	R:R:R172	2.51	No	No	0	5	5
471	R:R:F327	R:R:M301	2.49	No	No	0	3	5
472	S:S:F327	S:S:M301	2.49	No	No	0	3	5
473	S:S:F146	S:S:L240	2.44	No	No	0	6	2
474	R:R:L129	R:R:R128	2.43	No	No	0	5	2
475	S:S:L129	S:S:R128	2.43	No	No	0	5	2
476	R:R:E121	R:R:R119	2.33	No	No	0	2	4
477	S:S:E154	S:S:F88	2.33	No	No	0	8	8
478	R:R:L90	R:R:W94	2.28	No	Yes	0	6	8
479	R:R:L97	R:R:W94	2.28	No	Yes	0	6	8
480	S:S:L90	S:S:W94	2.28	No	Yes	0	6	8
481	S:S:L97	S:S:W94	2.28	No	Yes	0	6	8
482	R:R:C260	R:R:G274	1.96	No	No	0	5	5
483	R:R:A69	R:R:P343	1.87	No	Yes	0	9	9
484	R:R:A331	R:R:P297	1.87	No	No	0	7	9
485	S:S:A69	S:S:P343	1.87	No	Yes	0	9	9
486	S:S:A331	S:S:P297	1.87	No	No	0	7	9
487	R:R:G205	R:R:V201	1.84	No	Yes	0	6	5
488	S:S:G65	S:S:V64	1.84	No	No	0	9	4
489	S:S:G205	S:S:V201	1.84	No	Yes	0	6	5
490	R:R:A152	R:R:C248	1.81	No	No	0	9	7
491	R:R:A156	R:R:C248	1.81	No	No	0	6	7
492	S:S:A156	S:S:C248	1.81	No	Yes	0	6	7
493	R:R:P297	R:R:S296	1.78	No	No	0	9	6
494	S:S:P125	S:S:S126	1.78	No	No	0	4	4
495	S:S:P297	S:S:S296	1.78	No	No	0	9	6
496	R:R:C248	R:R:V153	1.71	No	No	0	7	6
497	R:R:A166	R:R:S167	1.71	No	No	0	5	4
498	R:R:G286	R:R:L289	1.71	No	No	0	5	4
499	S:S:C248	S:S:V153	1.71	Yes	No	0	7	6
500	S:S:G213	S:S:L228	1.71	No	No	0	3	4
501	S:S:C248	S:S:V244	1.71	Yes	No	0	7	5
502	S:S:G286	S:S:L289	1.71	No	No	0	5	4
503	R:R:A150	R:R:V177	1.7	No	No	0	7	5
504	R:R:G197	R:R:N227	1.7	No	No	0	7	5
505	R:R:G226	R:R:N227	1.7	No	No	0	1	5
506	S:S:A150	S:S:V177	1.7	No	No	0	7	5
507	S:S:G226	S:S:N227	1.7	No	Yes	0	1	5
508	R:R:I159	R:R:P162	1.69	No	No	0	8	9
509	S:S:I159	S:S:P162	1.69	Yes	No	0	8	9
510	R:R:S74	R:R:V73	1.62	No	Yes	0	3	8
511	R:R:A255	R:R:I159	1.62	No	No	0	7	8
512	R:R:S292	R:R:V293	1.62	No	No	0	6	6
513	S:S:S74	S:S:V73	1.62	No	Yes	0	3	8
514	S:S:A255	S:S:I159	1.62	No	Yes	0	7	8
515	S:S:A281	S:S:I253	1.62	No	Yes	0	7	6
516	S:S:S292	S:S:V293	1.62	No	No	0	6	6
517	R:R:A148	R:R:M151	1.61	No	No	0	8	9
518	R:R:S247	R:R:T243	1.6	No	No	0	3	4
519	S:S:S247	S:S:T243	1.6	No	No	0	3	4
520	R:R:T131	R:R:V193	1.59	No	No	0	5	4
521	S:S:T131	S:S:V193	1.59	No	No	0	5	4
522	R:R:T57	R:R:T61	1.57	No	No	0	4	6
523	R:R:T277	R:R:T278	1.57	No	No	0	8	5
524	S:S:T57	S:S:T61	1.57	No	No	0	4	6
525	S:S:T277	S:S:T278	1.57	No	No	0	8	5
526	S:S:I300	S:S:S296	1.55	No	No	0	7	6
527	R:R:I123	R:R:V113	1.54	No	No	0	3	7
528	R:R:I173	R:R:V177	1.54	No	No	0	5	5
529	R:R:I253	R:R:V257	1.54	No	No	0	6	5
530	S:S:I123	S:S:V113	1.54	No	No	0	3	7
531	S:S:I173	S:S:V177	1.54	No	No	0	5	5
532	S:S:I253	S:S:V257	1.54	Yes	No	0	6	5
533	R:R:I159	R:R:T252	1.52	No	No	0	8	9
534	R:R:I276	R:R:T280	1.52	No	No	0	6	8
535	S:S:I159	S:S:T252	1.52	Yes	No	0	8	9
536	S:S:I276	S:S:T280	1.52	No	No	0	6	8
537	S:S:L89	S:S:S76	1.5	No	No	0	8	7
538	R:R:L89	R:R:V73	1.49	No	Yes	0	8	8
539	R:R:L347	R:R:V73	1.49	No	Yes	0	9	8
540	R:R:L194	R:R:V193	1.49	No	No	0	4	4
541	S:S:L89	S:S:V73	1.49	No	Yes	0	8	8
542	S:S:L347	S:S:V73	1.49	No	Yes	0	9	8
543	S:S:L186	S:S:V139	1.49	No	No	0	4	7
544	R:R:I253	R:R:M285	1.46	No	No	0	6	6
545	R:R:D258	R:R:V257	1.46	No	No	0	4	5
546	R:R:I282	R:R:M285	1.46	No	No	0	5	6
547	S:S:I253	S:S:M285	1.46	Yes	No	0	6	6
548	S:S:I282	S:S:M285	1.46	No	No	0	5	6
549	S:S:I300	S:S:K304	1.45	No	No	0	7	3
550	R:R:I56	R:R:L60	1.43	No	No	0	4	5
551	S:S:I56	S:S:L60	1.43	No	No	0	4	5
552	S:S:I159	S:S:L256	1.43	Yes	No	0	8	8
553	R:R:E279	R:R:T278	1.41	No	No	0	7	5
554	R:R:A67	R:R:F63	1.39	No	No	0	5	7
555	R:R:L68	S:S:L349	1.38	Yes	No	0	5	7
556	R:R:L68	S:S:L353	1.38	Yes	No	0	5	7
557	R:R:L71	R:R:L72	1.38	No	No	0	4	8
558	R:R:L71	S:S:L353	1.38	No	No	0	4	7
559	R:R:L135	R:R:L190	1.38	Yes	No	0	6	6
560	R:R:L186	R:R:L190	1.38	No	No	0	4	6
561	R:R:L239	R:R:L303	1.38	No	No	11	6	5
562	R:R:L349	S:S:L68	1.38	No	Yes	0	7	5
563	R:R:L353	S:S:L68	1.38	No	Yes	0	7	5
564	R:R:L353	S:S:L71	1.38	No	No	0	7	4
565	S:S:L71	S:S:L72	1.38	No	No	0	4	8
566	S:S:L135	S:S:L190	1.38	Yes	No	0	6	6
567	S:S:L190	S:S:L194	1.38	No	No	0	6	4
568	S:S:L239	S:S:L303	1.38	No	No	15	6	5
569	S:S:A148	S:S:Y346	1.33	No	Yes	0	8	9
570	R:R:A161	R:R:W164	1.3	No	No	0	4	4
571	S:S:A161	S:S:W164	1.3	No	No	0	4	4
572	R:R:T131	R:R:Y199	1.25	No	Yes	0	5	6
573	S:S:K170	S:S:R172	1.24	No	No	0	6	5
574	R:R:F236	R:R:L239	1.22	No	No	11	4	6
575	R:R:F236	R:R:L303	1.22	No	No	11	4	5
576	S:S:F236	S:S:L239	1.22	No	No	15	4	6
577	S:S:F236	S:S:L303	1.22	No	No	15	4	5
578	R:R:Q272	R:R:R275	1.17	No	No	0	3	6
579	S:S:L89	S:S:Y77	1.17	No	No	0	8	6
580	S:S:E121	S:S:R119	1.16	No	No	0	2	4
581	R:R:L179	R:R:W182	1.14	No	Yes	10	3	7
582	R:R:L183	R:R:W182	1.14	No	Yes	10	3	7
583	S:S:L179	S:S:W182	1.14	No	Yes	14	3	7
584	S:S:L183	S:S:W182	1.14	No	Yes	14	3	7
585	S:S:Q272	S:S:W273	1.1	No	No	0	3	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	8.61467	15	2	0
2	M:M:?1	8.64933	15	1	0
3	R:R:F54	8.04	4	0	4
4	R:R:N66	4.988	5	0	9
5	R:R:L68	2.558	5	0	5
6	R:R:V73	2.53	4	0	8
7	R:R:W94	2.9325	4	0	8
8	R:R:D99	7.31	4	2	9
9	R:R:T107	7.9825	4	0	8
10	R:R:Y114	9.1875	4	2	8
11	R:R:W120	5.48286	7	5	5
12	R:R:D124	5.715	4	0	6
13	R:R:F133	5.23	5	5	6
14	R:R:L135	3.1525	4	0	6
15	R:R:R155	4.69	4	9	9
16	R:R:M169	7.5075	4	8	5
17	R:R:W182	3.0225	4	10	7
18	R:R:F188	5.93	4	0	8
19	R:R:Y199	6.58	6	7	6
20	R:R:V201	3.9175	4	5	5
21	R:R:Q202	6.57	4	2	8
22	R:R:W203	9.95	4	0	4
23	R:R:T206	6.698	5	2	8
24	R:R:W207	8.70143	7	2	7
25	R:R:C208	5.355	4	5	9
26	R:R:F230	7.98333	6	7	6
27	R:R:F234	4.5075	4	0	8
28	R:R:L284	6.085	4	0	9
29	R:R:L291	4.4075	4	0	9
30	R:R:W295	7.61667	6	2	8
31	R:R:I306	6.208	5	0	5
32	R:R:F328	4.225	6	2	6
33	R:R:L329	6.19	5	2	7
34	R:R:R333	9.15	4	2	8
35	R:R:N338	7.68	5	2	9
36	R:R:Q339	7.19833	6	2	8
37	R:R:D342	6.4675	4	2	9
38	R:R:P343	4.5325	4	3	9
39	R:R:W344	6.1375	4	3	8
40	R:R:Y346	5.954	5	9	9
41	S:S:V50	4.9325	4	1	4
42	S:S:F54	8.04	4	0	4
43	S:S:N66	4.988	5	0	9
44	S:S:L68	2.4525	4	0	5
45	S:S:V73	2.53	4	0	8
46	S:S:W94	3.4	4	0	8
47	S:S:D99	6.732	5	1	9
48	S:S:T107	8.26	4	0	8
49	S:S:Y114	9.1875	4	1	8
50	S:S:W120	5.55	6	6	5
51	S:S:D124	5.715	4	0	6
52	S:S:F133	4.982	5	6	6
53	S:S:L135	3.1525	4	0	6
54	S:S:R155	4.69	4	13	9
55	S:S:I159	2.756	5	0	8
56	S:S:M169	9.0025	4	12	5
57	S:S:W182	3.49	4	14	7
58	S:S:F188	5.474	5	4	8
59	S:S:Y199	7.936	5	4	6
60	S:S:V201	3.56	4	6	5
61	S:S:W203	8.696	5	1	4
62	S:S:T206	6.295	6	1	8
63	S:S:W207	8.57857	7	1	7
64	S:S:C208	5.0275	4	6	9
65	S:S:N227	4.3275	4	0	5
66	S:S:F230	7.98333	6	4	6
67	S:S:F234	4.82	4	4	8
68	S:S:C248	2.21	4	0	7
69	S:S:I253	2.94	4	0	6
70	S:S:L284	6.4425	4	0	9
71	S:S:W295	7.33429	7	1	8
72	S:S:L298	3.5475	4	0	7
73	S:S:I306	6.208	5	0	5
74	S:S:F328	4.01667	6	1	6
75	S:S:L329	6.87	4	1	7
76	S:S:R333	9.605	4	1	8
77	S:S:N338	7.372	5	1	9
78	S:S:Q339	7.545	6	1	8
79	S:S:D342	6.13	4	1	9
80	S:S:P343	4.282	5	3	9
81	S:S:W344	6.7075	4	3	8
82	S:S:Y346	4.98333	6	13	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:R333	86.7573	3.63	Yes	Yes	2	0	8
2	R:R:F54	R:R:R333	99.1396	17.1	Yes	Yes	0	4	8
3	R:R:F54	S:S:F54	99.5531	9.65	Yes	Yes	0	4	4
4	S:S:F54	S:S:R333	100	17.1	Yes	Yes	0	4	8
5	M:M:?1	S:S:R333	77.3468	5.45	Yes	Yes	1	0	8
6	M:M:?1	S:S:W207	24.1054	11.92	Yes	Yes	1	0	7
7	S:S:L329	S:S:R333	21.8368	12.15	Yes	Yes	1	7	8
8	S:S:L329	S:S:W207	20.5354	4.56	Yes	Yes	1	7	7
9	M:M:?1	S:S:W295	34.4725	3.41	Yes	Yes	1	0	8
10	M:M:?1	S:S:Q339	23.306	9.95	Yes	Yes	1	0	8
11	R:R:N66	R:R:P343	15.4503	8.15	Yes	Yes	0	9	9
12	R:R:P343	R:R:W344	15.3307	4.05	Yes	Yes	3	9	8
13	L:L:?1	R:R:Q339	46.2455	8.96	Yes	Yes	2	0	8
14	R:R:D99	R:R:Q339	15.5888	10.44	Yes	Yes	2	9	8
15	R:R:D99	R:R:L95	17.0386	5.43	Yes	No	0	9	9
16	R:R:I147	R:R:L95	16.4228	8.56	No	No	0	7	9
17	R:R:I147	R:R:L178	15.1876	4.28	No	No	0	7	7
18	R:R:N338	R:R:Q339	33.0819	7.92	Yes	Yes	2	9	8
19	R:R:L291	R:R:N338	35.0831	5.49	Yes	Yes	0	9	9
20	R:R:F246	R:R:L291	29.1928	3.65	No	Yes	0	5	9
21	R:R:F246	R:R:M288	26.4773	12.44	No	No	0	5	8
22	R:R:M288	R:R:N249	25.4028	7.01	No	No	0	8	9
23	L:L:?1	R:R:M137	34.5576	11.63	Yes	No	0	0	7
24	R:R:G134	R:R:M137	25.4655	3.49	No	No	0	7	7
25	R:R:G134	R:R:Y199	25.0057	8.69	No	Yes	0	7	6
26	L:L:?1	R:R:T106	10.98	5.51	Yes	No	0	0	6
27	R:R:F133	R:R:M137	10.3114	6.22	Yes	No	0	6	7
28	R:R:F133	R:R:W120	11.2562	4.01	Yes	Yes	5	6	5
29	R:R:F230	R:R:Y199	11.9729	3.09	Yes	Yes	7	6	6
30	R:R:L284	R:R:N249	19.7887	9.61	Yes	No	0	9	9
31	R:R:L284	R:R:T252	16.1225	2.95	Yes	No	0	9	9
32	R:R:I159	R:R:T252	15.5166	1.52	No	No	0	8	9
33	R:R:I159	R:R:P162	13.0814	1.69	No	No	0	8	9
34	R:R:F328	R:R:W207	12.2328	5.01	Yes	Yes	2	6	7
35	R:R:W344	S:S:W344	17.7624	3.75	Yes	Yes	3	8	8
36	S:S:P343	S:S:W344	12.39	4.05	Yes	Yes	3	9	8
37	S:S:N66	S:S:P343	15.77	8.15	Yes	Yes	0	9	9
38	S:S:D99	S:S:Q339	17.8415	10.44	Yes	Yes	1	9	8
39	S:S:D99	S:S:L95	13.6498	5.43	Yes	No	0	9	9
40	S:S:I147	S:S:L95	13.1595	8.56	No	No	0	7	9
41	S:S:I147	S:S:L178	12.1753	4.28	No	No	0	7	7
42	S:S:F328	S:S:W207	44.917	5.01	Yes	Yes	1	6	7
43	S:S:F328	S:S:L298	39.2772	3.65	Yes	Yes	0	6	7
44	S:S:L298	S:S:M302	62.8976	4.24	Yes	No	0	7	7
45	S:S:F234	S:S:M302	62.2161	3.73	Yes	No	0	8	7
46	S:S:F188	S:S:F234	21.9864	3.22	Yes	Yes	4	8	8
47	S:S:F188	S:S:F230	17.7283	12.86	Yes	Yes	4	8	6
48	S:S:F230	S:S:Y199	19.2263	3.09	Yes	Yes	4	6	6
49	S:S:L135	S:S:Y199	24.3881	3.52	Yes	Yes	0	6	6
50	S:S:L135	S:S:V139	17.7178	2.98	Yes	No	0	6	7
51	S:S:F140	S:S:V139	11.8164	3.93	No	No	0	8	7
52	S:S:A335	S:S:W295	29.0327	7.78	No	Yes	0	8	8
53	S:S:A335	S:S:L298	28.7553	3.15	No	Yes	0	8	7
54	S:S:F234	S:S:I210	37.3751	5.02	Yes	No	0	8	6
55	S:S:F230	S:S:I210	17.6169	8.79	Yes	No	0	6	6
56	S:S:I210	S:S:T138	19.0902	3.04	No	No	0	6	7
57	S:S:N338	S:S:W295	17.821	9.04	Yes	Yes	1	9	8
58	S:S:L291	S:S:N338	33.6057	6.87	No	Yes	0	9	9
59	S:S:F246	S:S:L291	32.3095	3.65	No	No	0	5	9
60	S:S:F246	S:S:M288	29.0573	12.44	No	No	0	5	8
61	S:S:M288	S:S:N249	27.7517	7.01	No	No	0	8	9
62	S:S:N338	S:S:Q339	16.1354	7.92	Yes	Yes	1	9	8
63	S:S:L284	S:S:N249	22.0139	9.61	Yes	No	0	9	9
64	S:S:L284	S:S:T252	14.6269	2.95	Yes	No	0	9	9
65	S:S:I159	S:S:T252	13.9067	1.52	Yes	No	0	8	9
66	S:S:L135	S:S:L190	11.8164	1.38	Yes	No	0	6	6
67	R:R:L329	R:R:R333	10.651	12.15	Yes	Yes	2	7	8
68	S:S:D99	S:S:N66	15.4726	5.39	Yes	Yes	0	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
M:M:?1	S:S:P55	3.68	1	Yes	No	0	7	0	1
M:M:?1	S:S:M58	9.51	1	Yes	No	0	8	0	1
M:M:?1	S:S:T106	5.51	1	Yes	No	0	6	0	1
M:M:?1	S:S:T107	13.23	1	Yes	Yes	0	8	0	1
M:M:?1	S:S:V110	6.68	1	Yes	No	0	8	0	1
M:M:?1	S:S:Y114	7.89	1	Yes	Yes	0	8	0	1
M:M:?1	S:S:M137	10.57	1	Yes	No	0	7	0	1
M:M:?1	S:S:T206	7.72	1	Yes	Yes	0	8	0	1
M:M:?1	S:S:W207	11.92	1	Yes	Yes	0	7	0	1
M:M:?1	S:S:W295	3.41	1	Yes	Yes	0	8	0	1
M:M:?1	S:S:L329	6.21	1	Yes	Yes	0	7	0	1
M:M:?1	S:S:V332	6.68	1	Yes	No	0	7	0	1
M:M:?1	S:S:R333	5.45	1	Yes	Yes	0	8	0	1
M:M:?1	S:S:S336	21.33	1	Yes	No	0	8	0	1
M:M:?1	S:S:Q339	9.95	1	Yes	Yes	0	8	0	1
S:S:V50	S:S:Y114	3.79	1	Yes	Yes	4	8	2	1
S:S:V50	S:S:W203	3.68	1	Yes	Yes	4	4	2	2
S:S:P204	S:S:V50	8.84	1	No	Yes	7	4	2	2
S:S:I111	S:S:V52	4.61	0	No	No	7	5	2	2
S:S:V52	S:S:Y114	10.09	0	No	Yes	5	8	2	1
S:S:F54	S:S:R333	17.1	0	Yes	Yes	4	8	2	1
S:S:P55	S:S:V110	3.53	1	No	No	7	8	1	1
S:S:M58	S:S:R333	3.72	1	No	Yes	8	8	1	1
S:S:I340	S:S:M58	4.37	0	No	No	9	8	2	1
S:S:L59	S:S:T107	13.27	0	No	Yes	7	8	2	1
S:S:D99	S:S:S144	4.42	1	Yes	No	9	8	2	2
S:S:D99	S:S:Q339	10.44	1	Yes	Yes	9	8	2	1
S:S:D342	S:S:D99	7.98	1	Yes	Yes	9	9	2	2
S:S:F133	S:S:T106	6.49	6	Yes	No	6	6	2	1
S:S:T106	S:S:T136	3.14	0	No	No	6	5	1	2
S:S:P108	S:S:T107	3.5	0	No	Yes	8	8	2	1
S:S:I111	S:S:T107	3.04	0	No	Yes	7	8	2	1
S:S:T206	S:S:V110	3.17	1	Yes	No	8	8	1	1
S:S:T206	S:S:V113	4.76	1	Yes	No	8	7	1	2
S:S:T206	S:S:Y114	14.98	1	Yes	Yes	8	8	1	1
S:S:F133	S:S:M137	4.98	6	Yes	No	6	7	2	1
S:S:Q339	S:S:S144	8.66	1	Yes	No	8	8	1	2
S:S:D342	S:S:S144	5.89	1	Yes	No	9	8	2	2
S:S:L145	S:S:W295	20.5	0	No	Yes	8	8	2	1
S:S:Q202	S:S:W207	16.43	1	No	Yes	8	7	2	1
S:S:F209	S:S:Q202	3.51	1	No	No	8	8	2	2
S:S:F328	S:S:Q202	3.51	1	Yes	No	6	8	2	2
S:S:P204	S:S:W203	20.27	1	No	Yes	7	4	2	2
S:S:L329	S:S:W203	4.56	1	Yes	Yes	7	4	1	2
S:S:P204	S:S:T206	3.5	1	No	Yes	7	8	2	1
S:S:T206	S:S:W207	3.64	1	Yes	Yes	8	7	1	1
S:S:F209	S:S:W207	5.01	1	No	Yes	8	7	2	1
S:S:F328	S:S:W207	5.01	1	Yes	Yes	6	7	2	1
S:S:L329	S:S:W207	4.56	1	Yes	Yes	7	7	1	1
S:S:V332	S:S:W207	13.48	1	No	Yes	7	7	1	1
S:S:F209	S:S:F328	3.22	1	No	Yes	8	6	2	2
S:S:L299	S:S:W295	3.42	0	No	Yes	8	8	2	1
S:S:A335	S:S:W295	7.78	0	No	Yes	8	8	2	1
S:S:N338	S:S:W295	9.04	1	Yes	Yes	9	8	2	1
S:S:Q339	S:S:W295	4.38	1	Yes	Yes	8	8	1	1
S:S:L329	S:S:R333	12.15	1	Yes	Yes	7	8	1	1
S:S:N338	S:S:Q339	7.92	1	Yes	Yes	9	8	2	1
S:S:D342	S:S:N338	6.73	1	Yes	Yes	9	9	2	2
S:S:D342	S:S:Q339	3.92	1	Yes	Yes	9	8	2	1
S:S:G141	S:S:W295	2.81	0	No	Yes	7	8	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:P55	3.68	2	Yes	No	0	7	0	1
L:L:?1	R:R:M58	10.57	2	Yes	No	0	8	0	1
L:L:?1	R:R:Q103	5.97	2	Yes	No	0	8	0	1
L:L:?1	R:R:T106	5.51	2	Yes	No	0	6	0	1
L:L:?1	R:R:T107	12.12	2	Yes	Yes	0	8	0	1
L:L:?1	R:R:V110	6.68	2	Yes	No	0	8	0	1
L:L:?1	R:R:Y114	7.89	2	Yes	Yes	0	8	0	1
L:L:?1	R:R:M137	11.63	2	Yes	No	0	7	0	1
L:L:?1	R:R:T206	6.61	2	Yes	Yes	0	8	0	1
L:L:?1	R:R:W207	12.78	2	Yes	Yes	0	7	0	1
L:L:?1	R:R:L329	5.18	2	Yes	Yes	0	7	0	1
L:L:?1	R:R:V332	6.68	2	Yes	No	0	7	0	1
L:L:?1	R:R:R333	3.63	2	Yes	Yes	0	8	0	1
L:L:?1	R:R:S336	21.33	2	Yes	No	0	8	0	1
L:L:?1	R:R:Q339	8.96	2	Yes	Yes	0	8	0	1
R:R:L329	R:R:S49	4.5	2	Yes	No	7	4	1	2
R:R:V50	R:R:Y114	3.79	0	No	Yes	4	8	2	1
R:R:P204	R:R:V50	8.84	0	No	No	7	4	2	2
R:R:I111	R:R:V52	4.61	0	No	No	7	5	2	2
R:R:V52	R:R:Y114	10.09	0	No	Yes	5	8	2	1
R:R:F54	R:R:R333	17.1	0	Yes	Yes	4	8	2	1
R:R:P55	R:R:V110	3.53	2	No	No	7	8	1	1
R:R:M58	R:R:R333	3.72	2	No	Yes	8	8	1	1
R:R:I340	R:R:M58	4.37	0	No	No	9	8	2	1
R:R:L59	R:R:T107	13.27	0	No	Yes	7	8	2	1
R:R:G62	R:R:Q103	4.93	0	No	No	9	8	2	1
R:R:G62	R:R:I340	3.53	0	No	No	9	9	2	2
R:R:D99	R:R:N66	5.39	2	Yes	Yes	9	9	2	2
R:R:N66	R:R:Q103	3.96	0	Yes	No	9	8	2	1
R:R:D99	R:R:Q339	10.44	2	Yes	Yes	9	8	2	1
R:R:D342	R:R:D99	7.98	2	Yes	Yes	9	9	2	2
R:R:F133	R:R:T106	6.49	5	Yes	No	6	6	2	1
R:R:T106	R:R:T136	3.14	0	No	No	6	5	1	2
R:R:P108	R:R:T107	3.5	0	No	Yes	8	8	2	1
R:R:I111	R:R:T107	3.04	0	No	Yes	7	8	2	1
R:R:T206	R:R:V113	4.76	2	Yes	No	8	7	1	2
R:R:T206	R:R:Y114	14.98	2	Yes	Yes	8	8	1	1
R:R:F133	R:R:M137	6.22	5	Yes	No	6	7	2	1
R:R:G134	R:R:M137	3.49	0	No	No	7	7	2	1
R:R:Q339	R:R:S144	8.66	2	Yes	No	8	8	1	2
R:R:D342	R:R:S144	5.89	2	Yes	No	9	8	2	2
R:R:Q202	R:R:W207	16.43	2	Yes	Yes	8	7	2	1
R:R:F209	R:R:Q202	3.51	2	No	Yes	8	8	2	2
R:R:F328	R:R:Q202	3.51	2	Yes	Yes	6	8	2	2
R:R:P204	R:R:W203	20.27	0	No	Yes	7	4	2	2
R:R:L329	R:R:W203	4.56	2	Yes	Yes	7	4	1	2
R:R:P204	R:R:T206	3.5	0	No	Yes	7	8	2	1
R:R:T206	R:R:W207	3.64	2	Yes	Yes	8	7	1	1
R:R:F209	R:R:W207	5.01	2	No	Yes	8	7	2	1
R:R:F328	R:R:W207	5.01	2	Yes	Yes	6	7	2	1
R:R:L329	R:R:W207	4.56	2	Yes	Yes	7	7	1	1
R:R:V332	R:R:W207	13.48	2	No	Yes	7	7	1	1
R:R:F209	R:R:F328	3.22	2	No	Yes	8	6	2	2
R:R:N338	R:R:W295	9.04	2	Yes	Yes	9	8	2	2
R:R:Q339	R:R:W295	3.29	2	Yes	Yes	8	8	1	2
R:R:L329	R:R:R333	12.15	2	Yes	Yes	7	8	1	1
R:R:N338	R:R:Q339	7.92	2	Yes	Yes	9	8	2	1
R:R:D342	R:R:N338	8.08	2	Yes	Yes	9	9	2	2
R:R:D342	R:R:Q339	3.92	2	Yes	Yes	9	8	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	6AK3_poly
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.04
Number of Linked Nodes	507
Number of Links	585
Number of Hubs	82
Number of Links mediated by Hubs	318
Number of Communities	15
Number of Nodes involved in Communities	94
Number of Links involved in Communities	136

Path Summary
Number Of Nodes in MetaPath	69
Number Of Links MetaPath	68
Number of Shortest Paths	317538
Length Of Smallest Path	3
Average Path Length	16.9453
Length of Longest Path	40
Minimum Path Strength	1.33
Average Path Strength	6.55916
Maximum Path Strength	19.19
Minimum Path Correlation	0.7
Average Path Correlation	0.962751
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.57143
Average % Of Corr. Nodes	53.498
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	56.7334
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • tetrapyrrole binding • heme binding • electron transfer activity • cation binding • transition metal ion binding • iron ion binding • ion binding • metal ion binding • small molecule binding • prostaglandin E receptor activity • prostanoid receptor activity • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • icosanoid receptor activity • prostaglandin receptor activity • electron transport chain • metabolic process • cellular process • generation of precursor metabolites and energy • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway
Gene Ontology	Biological Process	• electron transport chain • metabolic process • cellular process • generation of precursor metabolites and energy • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • intestine smooth muscle contraction • multicellular organismal process • gastro-intestinal system smooth muscle contraction • system process • smooth muscle contraction • phasic smooth muscle contraction • muscle contraction • muscle system process • cell death • phospholipase C-activating G protein-coupled receptor signaling pathway • defense response • response to stress • inflammatory response • regulation of localization • transport • digestive system process • regulation of system process • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • regulation of multicellular organismal process • negative regulation of digestive system process • regulation of gastric acid secretion • regulation of transport • secretion • acid secretion • regulation of digestive system process • establishment of localization • gastric acid secretion • regulation of secretion • digestion • negative regulation of multicellular organismal process • negative regulation of gastric acid secretion • acute-phase response • regulation of defense response • regulation of heat generation • regulation of response to external stimulus • homeostatic process • positive regulation of heat generation • positive regulation of biological process • positive regulation of acute inflammatory response • heat generation • positive regulation of response to stimulus • positive regulation of response to external stimulus • positive regulation of inflammatory response • regulation of response to stress • positive regulation of fever generation • acute inflammatory response • fever generation • response to external stimulus • regulation of inflammatory response • multicellular organismal-level homeostasis • regulation of response to stimulus • positive regulation of defense response • temperature homeostasis • regulation of acute inflammatory response • positive regulation of multicellular organismal process • regulation of fever generation • cellular anatomical structure • periplasmic space • membrane • membrane-bounded organelle • intracellular organelle • organelle envelope • intracellular anatomical structure • organelle • nuclear envelope • nucleus • intracellular membrane-bounded organelle • endomembrane system • cell periphery • plasma membrane
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• G protein-coupled receptor-like
SCOP2	Family Identifier	• G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	P2E
PDB Residues	L:L:?1 M:M:?1
Environment Details	Open EMBL-EBI Page
Code	P2E
Name	Dinoprostone
Synonyms	(5Z,13E)-(15S)-11alpha,15-Dihydroxy-9-oxoprost-13-enoate
Identifier
Formula	C20 H32 O5
Molecular Weight	352.465
SMILES
PubChem	5280360
Formal Charge	0
Total Atoms	57
Total Chiral Atoms	4
Total Bonds	57
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P43115
Sequence	>6AK3_poly_Chain_R C G S V S V A F P I T M L L T G F V G N A L A M L L V S R S R K S F L L C I G W L A L T D L V G Q L L T T P V V I V V Y L S K R W E H I D P G R L C T F F G L T M T V F G L S S L F I A S A M A V E R A L A I R A P H W Y A S H M K T R I T R A V L L G V W L A S L A F A L L P V L G V G Q Y T V Q W P G T W C F I S T G G N L F F A S A F A F L G L L A L T V T F S C N L A T I K A L V D R C R A K A A Q W G R I T T E T A I Q L M G I M L V L S V C W S P L L I M M L K M I F K E C N F F L I A V R L A S L N Q I L D P W V Y L L L R K I L L R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

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