psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:P24	5.03	Yes	No	0	0	7
2	L:L:?1	R:R:V72	10.28	Yes	No	1	0	7
3	L:L:?1	R:R:S73	8.06	Yes	Yes	0	0	8
4	L:L:?1	R:R:T76	11.3	Yes	No	0	0	8
5	L:L:?1	R:R:Y80	6.29	Yes	No	1	0	6
6	L:L:?1	R:R:L99	7.43	Yes	Yes	1	0	8
7	L:L:?1	R:R:S103	5.75	Yes	No	0	0	7
8	L:L:?1	R:R:T168	4.52	Yes	Yes	1	0	6
9	L:L:?1	R:R:W169	10.47	Yes	Yes	1	0	5
10	L:L:?1	R:R:L312	5.3	Yes	No	1	0	6
11	L:L:?1	R:R:R316	4.66	Yes	Yes	1	0	7
12	L:L:?1	R:R:S319	14.96	Yes	No	0	0	8
13	L:L:?1	R:R:P322	3.78	Yes	No	0	0	9
14	R:R:P20	R:R:S19	3.56	No	No	0	5	1
15	R:R:S19	R:R:V21	3.23	No	No	0	1	6
16	R:R:P24	R:R:V21	3.53	No	No	0	7	6
17	R:R:V21	R:R:Y80	16.4	No	No	0	6	6
18	R:R:I23	R:R:P24	3.39	No	No	0	6	7
19	R:R:I23	R:R:R316	6.26	No	Yes	0	6	7
20	R:R:M27	R:R:R316	4.96	No	Yes	0	8	7
21	R:R:F28	R:R:V32	3.93	No	No	0	6	7
22	R:R:F28	R:R:S73	9.25	No	Yes	0	6	8
23	R:R:F30	R:R:I323	3.77	No	Yes	0	5	8
24	R:R:L70	R:R:V32	2.98	No	No	0	5	7
25	R:R:D65	R:R:N35	4.04	Yes	No	0	9	9
26	R:R:L66	R:R:N35	4.12	No	No	0	8	9
27	R:R:N35	R:R:P326	6.52	No	No	0	9	9
28	R:R:L331	R:R:V37	4.47	Yes	No	0	6	6
29	R:R:K44	R:R:V40	4.55	No	No	0	6	5
30	R:R:L331	R:R:V41	2.98	Yes	No	0	6	7
31	R:R:V336	R:R:V41	3.21	No	No	0	7	7
32	R:R:L42	R:R:Y55	8.21	Yes	No	3	8	8
33	R:R:C59	R:R:L42	7.94	No	Yes	3	6	8
34	R:R:I330	R:R:L42	4.28	No	Yes	0	8	8
35	R:R:Q49	R:R:S45	4.33	No	No	0	6	6
36	R:R:S45	R:R:Y55	3.82	No	No	0	6	8
37	R:R:E116	R:R:T53	4.23	No	No	4	9	6
38	R:R:T53	R:R:Y127	3.75	No	Yes	4	6	8
39	R:R:A136	R:R:T53	3.36	No	No	0	8	6
40	R:R:F54	R:R:V58	9.18	No	No	0	8	8
41	R:R:F54	R:R:M113	3.73	No	No	0	8	9
42	R:R:C59	R:R:Y55	9.41	No	No	3	6	8
43	R:R:L57	R:R:T56	2.95	No	No	0	8	6
44	R:R:A136	R:R:T56	3.36	No	No	0	8	6
45	R:R:I330	R:R:V58	3.07	No	No	0	8	8
46	R:R:D65	R:R:L61	5.43	Yes	No	2	9	9
47	R:R:I109	R:R:L61	5.71	Yes	No	2	8	9
48	R:R:D325	R:R:L61	5.43	No	No	2	9	9
49	R:R:S105	R:R:T64	6.4	Yes	No	0	8	9
50	R:R:D65	R:R:P322	11.27	Yes	No	0	9	9
51	R:R:D325	R:R:D65	6.65	No	Yes	2	9	9
52	R:R:F102	R:R:G68	9.03	Yes	No	0	7	8
53	R:R:S73	R:R:T69	3.2	Yes	No	0	8	8
54	R:R:I98	R:R:V72	4.61	Yes	No	0	5	7
55	R:R:L99	R:R:V72	4.47	Yes	No	1	8	7
56	R:R:P74	R:R:S73	3.56	No	Yes	0	9	8
57	R:R:L91	R:R:V75	2.98	No	No	0	6	7
58	R:R:I77	R:R:M81	5.83	No	No	0	6	4
59	R:R:T79	R:R:W85	3.64	No	No	1	7	6
60	R:R:P86	R:R:T79	3.5	No	No	1	4	7
61	R:R:T168	R:R:T79	3.14	Yes	No	1	6	7
62	R:R:T168	R:R:Y80	9.99	Yes	No	1	6	6
63	R:R:K82	R:R:Q84	24.41	No	No	0	5	4
64	R:R:P86	R:R:W85	4.05	No	No	1	4	6
65	R:R:L91	R:R:W85	4.56	No	No	0	6	6
66	R:R:C92	R:R:S161	3.44	No	No	0	9	5
67	R:R:C170	R:R:C92	7.28	No	No	0	9	9
68	R:R:E93	R:R:N155	3.94	No	No	0	6	5
69	R:R:I98	R:R:Y94	8.46	Yes	No	0	5	5
70	R:R:L99	R:R:S95	3	Yes	No	0	8	6
71	R:R:L100	R:R:T96	2.95	Yes	No	0	7	7
72	R:R:S161	R:R:T96	6.4	No	No	0	5	7
73	R:R:C151	R:R:F97	8.38	No	No	0	8	7
74	R:R:F102	R:R:I98	6.28	Yes	Yes	0	7	5
75	R:R:F171	R:R:L99	7.31	Yes	Yes	1	6	8
76	R:R:C151	R:R:L100	6.35	No	Yes	0	8	7
77	R:R:F171	R:R:L100	4.87	Yes	Yes	1	6	7
78	R:R:I172	R:R:L100	4.28	No	Yes	1	7	7
79	R:R:L100	R:R:Y184	4.69	Yes	Yes	0	7	8
80	R:R:F101	R:R:F102	8.57	No	Yes	0	7	7
81	R:R:F101	R:R:V148	5.24	No	No	0	7	4
82	R:R:L104	R:R:Y188	7.03	No	No	0	8	7
83	R:R:I109	R:R:S105	3.1	Yes	Yes	2	8	8
84	R:R:S105	R:R:Y144	5.09	Yes	No	2	8	8
85	R:R:N147	R:R:S105	2.98	Yes	Yes	0	8	8
86	R:R:L107	R:R:S192	3	No	No	0	8	7
87	R:R:S108	R:R:V143	3.23	No	No	0	7	7
88	R:R:N147	R:R:S108	5.96	Yes	No	0	8	7
89	R:R:L195	R:R:S108	3	Yes	No	0	8	7
90	R:R:I109	R:R:Y144	3.63	Yes	No	2	8	8
91	R:R:I110	R:R:T199	3.04	No	No	0	8	8
92	R:R:I110	R:R:Y329	6.04	No	Yes	0	8	9
93	R:R:C111	R:R:L195	3.17	No	Yes	0	7	8
94	R:R:C111	R:R:T199	3.38	No	No	0	7	8
95	R:R:M113	R:R:Y329	4.79	No	Yes	0	9	9
96	R:R:S114	R:R:T199	3.2	No	No	0	9	8
97	R:R:C202	R:R:S114	3.44	No	No	0	7	9
98	R:R:N203	R:R:S114	7.45	No	No	0	9	9
99	R:R:E116	R:R:Y127	4.49	No	Yes	4	9	8
100	R:R:L274	R:R:R117	4.86	Yes	No	0	8	9
101	R:R:N122	R:R:Y118	10.47	No	Yes	5	7	8
102	R:R:H123	R:R:Y118	4.36	No	Yes	0	7	8
103	R:R:L205	R:R:Y118	4.69	No	Yes	0	5	8
104	R:R:V206	R:R:Y118	3.79	Yes	Yes	5	9	8
105	R:R:A120	R:R:Y127	4	No	Yes	0	9	8
106	R:R:I121	R:R:V206	3.07	No	Yes	0	9	9
107	R:R:N122	R:R:V206	2.96	No	Yes	5	7	9
108	R:R:A209	R:R:N122	3.13	No	No	0	7	7
109	R:R:F126	R:R:Y130	8.25	No	No	0	5	5
110	R:R:V131	R:R:Y127	16.4	No	Yes	0	7	8
111	R:R:H129	R:R:S128	5.58	No	No	0	5	6
112	R:R:H129	R:R:Y130	8.71	No	No	0	5	5
113	R:R:D132	R:R:R134	4.76	No	No	0	8	5
114	R:R:F150	R:R:Y184	8.25	No	Yes	0	7	8
115	R:R:F150	R:R:M187	3.73	No	No	0	7	5
116	R:R:L153	R:R:L158	4.15	No	No	0	8	5
117	R:R:P154	R:R:Y184	19.47	No	Yes	0	9	8
118	R:R:L158	R:R:Y184	3.52	No	Yes	0	5	8
119	R:R:G159	R:R:H181	3.18	No	Yes	0	7	5
120	R:R:D173	R:R:S160	5.89	Yes	No	1	5	3
121	R:R:S160	R:R:T176	3.2	No	No	1	3	4
122	R:R:H181	R:R:S160	8.37	Yes	No	1	5	3
123	R:R:Q164	R:R:R162	5.84	Yes	No	1	7	4
124	R:R:D173	R:R:R162	20.25	Yes	No	1	5	4
125	R:R:R162	R:R:T175	10.35	No	No	1	4	4
126	R:R:D167	R:R:L163	4.07	No	No	0	5	4
127	R:R:Q164	R:R:W169	25.19	Yes	Yes	1	7	5
128	R:R:F171	R:R:Q164	3.51	Yes	Yes	1	6	7
129	R:R:Q164	R:R:W174	10.95	Yes	Yes	1	7	5
130	R:R:P166	R:R:Y165	11.13	No	Yes	0	6	3
131	R:R:L302	R:R:Y165	10.55	No	Yes	0	1	3
132	R:R:R304	R:R:Y165	6.17	No	Yes	0	1	3
133	R:R:N309	R:R:Y165	5.81	No	Yes	0	2	3
134	R:R:P166	R:R:T168	8.74	No	Yes	1	6	6
135	R:R:P166	R:R:W169	5.4	No	Yes	1	6	5
136	R:R:T168	R:R:W169	3.64	Yes	Yes	1	6	5
137	R:R:F171	R:R:W169	4.01	Yes	Yes	1	6	5
138	R:R:I315	R:R:W169	11.74	No	Yes	0	6	5
139	R:R:F171	R:R:I172	6.28	Yes	No	1	6	7
140	R:R:F171	R:R:W174	7.02	Yes	Yes	1	6	5
141	R:R:I172	R:R:W174	3.52	No	Yes	1	7	5
142	R:R:D173	R:R:T175	8.67	Yes	No	1	5	4
143	R:R:D173	R:R:T176	7.23	Yes	No	1	5	4
144	R:R:N295	R:R:W174	11.3	Yes	Yes	1	6	5
145	R:R:D311	R:R:W174	5.58	No	Yes	1	6	5
146	R:R:H181	R:R:T176	4.11	Yes	No	1	5	4
147	R:R:H181	R:R:V178	9.69	Yes	No	0	5	3
148	R:R:A182	R:R:Q296	3.03	No	No	0	5	6
149	R:R:Q296	R:R:S185	4.33	No	No	0	6	7
150	R:R:F293	R:R:Y186	3.09	No	No	0	6	5
151	R:R:Q296	R:R:Y186	5.64	No	No	0	6	5
152	R:R:L297	R:R:Y186	3.52	No	No	0	4	5
153	R:R:A189	R:R:F293	5.55	No	No	0	7	6
154	R:R:F191	R:R:L195	6.09	No	Yes	0	6	8
155	R:R:S192	R:R:V289	3.23	No	No	0	7	7
156	R:R:I196	R:R:S285	4.64	No	No	0	7	8
157	R:R:S278	R:R:V200	6.46	No	No	0	8	6
158	R:R:L282	R:R:V200	2.98	No	No	0	6	6
159	R:R:L274	R:R:N203	5.49	Yes	No	0	8	9
160	R:R:L210	R:R:V206	2.98	Yes	Yes	0	9	9
161	R:R:L274	R:R:V206	2.98	Yes	Yes	0	8	9
162	R:R:C207	R:R:L274	4.76	No	Yes	0	7	8
163	R:R:A209	R:R:R212	4.15	No	No	0	7	4
164	R:R:L210	R:R:V271	2.98	Yes	No	0	9	7
165	R:R:H214	R:R:M218	6.57	No	No	0	5	8
166	R:R:E267	R:R:H214	12.31	No	No	0	8	5
167	R:R:H214	R:R:I268	6.63	No	No	0	5	6
168	R:R:R215	R:R:R219	4.26	No	No	0	7	6
169	R:R:Q216	R:R:R219	8.18	No	No	0	9	6
170	R:R:F217	R:R:M218	3.73	No	No	0	9	8
171	R:R:F217	R:R:R220	4.28	No	No	0	9	9
172	R:R:F217	R:R:T221	3.89	No	No	0	9	9
173	R:R:L273	R:R:R333	4.86	No	No	0	8	9
174	R:R:T277	R:R:Y329	8.74	No	Yes	0	8	9
175	R:R:I328	R:R:V280	4.61	No	No	0	8	6
176	R:R:I286	R:R:L282	4.28	No	No	0	7	6
177	R:R:C284	R:R:V320	3.42	No	No	0	9	5
178	R:R:C284	R:R:N321	6.3	No	No	0	9	9
179	R:R:N321	R:R:S285	2.98	No	No	0	9	8
180	R:R:I286	R:R:P287	3.39	No	No	0	7	9
181	R:R:I317	R:R:P287	3.39	No	No	0	8	9
182	R:R:N295	R:R:R291	13.26	Yes	Yes	1	6	6
183	R:R:P310	R:R:R291	8.65	No	Yes	0	4	6
184	R:R:D311	R:R:R291	13.1	No	Yes	1	6	6
185	R:R:N295	R:R:P300	11.4	Yes	No	0	6	1
186	R:R:D311	R:R:N295	10.77	No	Yes	1	6	6
187	R:R:E303	R:R:R304	3.49	No	No	0	3	1
188	R:R:N309	R:R:P310	6.52	No	No	0	2	4
189	R:R:L312	R:R:N309	4.12	No	No	0	6	2
190	R:R:L312	R:R:R316	9.72	No	Yes	1	6	7
191	R:R:I323	R:R:V320	3.07	Yes	No	0	8	5
192	R:R:L331	R:R:W327	10.25	Yes	No	0	6	7
193	R:R:I328	R:R:Y329	3.63	No	Yes	0	8	9
194	R:R:I330	R:R:L331	4.28	No	Yes	0	8	6
195	R:R:I196	R:R:I286	2.94	No	No	0	7	7
196	R:R:I323	R:R:M27	2.92	Yes	No	0	8	8
197	R:R:I344	R:R:K343	2.91	No	No	0	5	4
198	R:R:I98	R:R:L71	2.85	Yes	No	0	5	6
199	R:R:I109	R:R:L140	2.85	Yes	No	0	8	8
200	R:R:L57	R:R:M113	2.83	No	No	0	8	9
201	R:R:L210	R:R:M213	2.83	Yes	No	0	9	7
202	R:R:L210	R:R:M270	2.83	Yes	No	0	9	9
203	R:R:A152	R:R:F97	2.77	No	No	0	6	7
204	R:R:L107	R:R:L195	2.77	No	Yes	0	8	8
205	R:R:L201	R:R:L205	2.77	No	No	0	4	5
206	R:R:A314	R:R:R291	2.77	No	Yes	0	7	6
207	R:R:L104	R:R:N147	2.75	No	Yes	0	8	8
208	R:R:E267	R:R:M213	2.71	No	No	0	8	7
209	R:R:E342	R:R:K339	2.7	No	No	0	4	7
210	R:R:F293	R:R:V289	2.62	No	No	0	6	7
211	R:R:R291	R:R:V294	2.62	Yes	No	0	6	5
212	R:R:R333	R:R:V336	2.62	No	No	0	9	7
213	R:R:H123	R:R:L119	2.57	No	No	0	7	6
214	R:R:V306	R:R:Y165	2.52	No	Yes	0	3	3
215	R:R:F102	R:R:L67	2.44	Yes	No	0	7	7
216	R:R:F194	R:R:L195	2.44	No	Yes	0	4	8
217	R:R:G87	R:R:G88	2.11	No	No	0	5	5
218	R:R:G88	R:R:P90	2.03	No	No	0	5	2
219	R:R:C59	R:R:G60	1.96	No	No	0	6	8
220	R:R:A136	R:R:G137	1.95	No	No	0	8	5
221	R:R:A189	R:R:G190	1.95	No	No	0	7	5
222	R:R:A38	R:R:P326	1.87	No	No	0	9	9
223	R:R:G190	R:R:S193	1.86	No	No	0	5	6
224	R:R:G34	R:R:V33	1.84	No	Yes	0	9	5
225	R:R:G60	R:R:V63	1.84	No	No	0	8	5
226	R:R:A198	R:R:C111	1.81	No	No	0	6	7
227	R:R:G31	R:R:I323	1.76	No	Yes	0	8	8
228	R:R:G87	R:R:L91	1.71	No	No	0	5	6
229	R:R:A180	R:R:V178	1.7	No	No	0	3	3
230	R:R:A189	R:R:V292	1.7	No	No	0	7	7
231	R:R:I77	R:R:P74	1.69	No	No	0	6	9
232	R:R:A112	R:R:T139	1.68	No	No	0	8	7
233	R:R:C43	R:R:I39	1.64	No	No	0	4	8
234	R:R:A78	R:R:I77	1.62	No	No	0	6	6
235	R:R:S285	R:R:V281	1.62	No	No	0	8	8
236	R:R:S19	R:R:T22	1.6	No	No	0	1	5
237	R:R:V32	R:R:V33	1.6	No	Yes	0	7	5
238	R:R:V33	R:R:V37	1.6	Yes	No	0	5	6
239	R:R:V200	R:R:V204	1.6	No	No	0	6	4
240	R:R:V290	R:R:V294	1.6	No	No	0	7	5
241	R:R:S338	R:R:T335	1.6	No	No	0	5	7
242	R:R:T22	R:R:V26	1.59	No	No	0	5	5
243	R:R:T139	R:R:V143	1.59	No	No	0	7	7
244	R:R:C170	R:R:L163	1.59	No	No	0	9	4
245	R:R:T335	R:R:V336	1.59	No	No	0	7	7
246	R:R:A62	R:R:L42	1.58	No	Yes	0	8	8
247	R:R:P86	R:R:Q84	1.58	No	No	0	4	4
248	R:R:P90	R:R:Q89	1.58	No	No	0	2	2
249	R:R:A318	R:R:L288	1.58	No	No	0	8	7
250	R:R:P300	R:R:Q299	1.58	No	No	0	1	2
251	R:R:E93	R:R:P90	1.57	No	No	0	6	2
252	R:R:I29	R:R:V33	1.54	No	Yes	0	5	5
253	R:R:K44	R:R:V41	1.52	No	No	0	6	7
254	R:R:A266	R:R:E267	1.51	No	No	0	7	8
255	R:R:K133	R:R:T56	1.5	No	No	0	5	6
256	R:R:N147	R:R:S146	1.49	Yes	No	0	8	5
257	R:R:L211	R:R:V271	1.49	No	No	0	6	7
258	R:R:L288	R:R:V292	1.49	No	No	0	7	7
259	R:R:I268	R:R:I272	1.47	No	No	0	6	7
260	R:R:Q299	R:R:S301	1.44	No	No	0	2	2
261	R:R:E305	R:R:S307	1.44	No	No	0	1	4
262	R:R:I39	R:R:L66	1.43	No	No	0	8	8
263	R:R:E305	R:R:V306	1.43	No	No	0	1	3
264	R:R:I323	R:R:L324	1.43	Yes	No	0	8	7
265	R:R:I328	R:R:L324	1.43	No	No	0	8	7
266	R:R:M156	R:R:N155	1.4	No	No	0	5	5
267	R:R:L36	R:R:L66	1.38	No	No	0	5	8
268	R:R:D132	R:R:K133	1.38	No	No	0	8	5
269	R:R:M213	R:R:Q216	1.36	No	No	0	7	9
270	R:R:E51	R:R:K47	1.35	No	No	0	7	6
271	R:R:E303	R:R:K308	1.35	No	No	0	3	4
272	R:R:E305	R:R:K308	1.35	No	No	0	1	4
273	R:R:F54	R:R:T52	1.3	No	No	0	8	7
274	R:R:F126	R:R:L119	1.22	No	No	0	5	6
275	R:R:Q49	R:R:R46	1.17	No	No	0	6	5
276	R:R:H129	R:R:Y125	1.09	No	No	0	5	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	7.52538	13	1	0
2	R:R:V33	1.645	4	0	5
3	R:R:L42	5.5025	4	3	8
4	R:R:D65	6.8475	4	2	9
5	R:R:S73	6.0175	4	0	8
6	R:R:I98	5.55	4	0	5
7	R:R:L99	5.5525	4	1	8
8	R:R:L100	4.628	5	1	7
9	R:R:F102	6.58	4	0	7
10	R:R:S105	4.3925	4	2	8
11	R:R:I109	3.8225	4	2	8
12	R:R:Y118	5.8275	4	5	8
13	R:R:Y127	7.16	4	4	8
14	R:R:N147	3.295	4	0	8
15	R:R:Q164	11.3725	4	1	7
16	R:R:Y165	7.236	5	0	3
17	R:R:T168	6.006	5	1	6
18	R:R:W169	10.075	6	1	5
19	R:R:F171	5.5	6	1	6
20	R:R:D173	10.51	4	1	5
21	R:R:W174	7.674	5	1	5
22	R:R:H181	6.3375	4	1	5
23	R:R:Y184	8.9825	4	0	8
24	R:R:L195	3.494	5	0	8
25	R:R:V206	3.156	5	5	9
26	R:R:L210	2.905	4	0	9
27	R:R:L274	4.5225	4	0	8
28	R:R:R291	8.08	5	1	6
29	R:R:N295	11.6825	4	1	6
30	R:R:R316	6.4	4	1	7
31	R:R:I323	2.59	5	0	8
32	R:R:Y329	5.8	4	0	9
33	R:R:L331	5.495	4	0	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:P24	13.7386	5.03	Yes	No	0	0	7
2	R:R:P24	R:R:V21	13.252	3.53	No	No	0	7	6
3	R:R:S19	R:R:V21	20.8952	3.23	No	No	0	1	6
4	L:L:?1	R:R:Y80	11.8159	6.29	Yes	No	1	0	6
5	R:R:V21	R:R:Y80	12.853	16.4	No	No	0	6	6
6	L:L:?1	R:R:R316	84.3067	4.66	Yes	Yes	1	0	7
7	R:R:M27	R:R:R316	100	4.96	No	Yes	0	8	7
8	L:L:?1	R:R:S73	51.7632	8.06	Yes	Yes	0	0	8
9	R:R:F28	R:R:S73	40.1787	9.25	No	Yes	0	6	8
10	R:R:F28	R:R:V32	38.3996	3.93	No	No	0	6	7
11	R:R:I323	R:R:M27	99.3936	2.92	Yes	No	0	8	8
12	L:L:?1	R:R:P322	63.4993	3.78	Yes	No	0	0	9
13	R:R:D65	R:R:P322	62.1908	11.27	Yes	No	0	9	9
14	R:R:D65	R:R:N35	16.7464	4.04	Yes	No	0	9	9
15	R:R:V32	R:R:V33	36.2295	1.6	No	Yes	0	7	5
16	R:R:V33	R:R:V37	33.812	1.6	Yes	No	0	5	6
17	R:R:L331	R:R:V37	33.0541	4.47	Yes	No	0	6	6
18	R:R:L331	R:R:V41	18.5974	2.98	Yes	No	0	6	7
19	R:R:V336	R:R:V41	11.5765	3.21	No	No	0	7	7
20	R:R:I330	R:R:L331	28.0517	4.28	No	Yes	0	8	6
21	R:R:I330	R:R:L42	20.9829	4.28	No	Yes	0	8	8
22	R:R:I323	R:R:L324	90.7133	1.43	Yes	No	0	8	7
23	R:R:I328	R:R:L324	90.0989	1.43	No	No	0	8	7
24	R:R:I328	R:R:Y329	88.966	3.63	No	Yes	0	8	9
25	R:R:M113	R:R:Y329	48.3006	4.79	No	Yes	0	9	9
26	R:R:L57	R:R:M113	27.2539	2.83	No	No	0	8	9
27	R:R:L57	R:R:T56	25.0519	2.95	No	No	0	8	6
28	R:R:A136	R:R:T56	16.0843	3.36	No	No	0	8	6
29	R:R:A136	R:R:T53	11.5047	3.36	No	No	0	8	6
30	R:R:F54	R:R:M113	25.2114	3.73	No	No	0	8	9
31	R:R:I330	R:R:V58	22.068	3.07	No	No	0	8	8
32	R:R:D65	R:R:L61	50.8377	5.43	Yes	No	2	9	9
33	R:R:I109	R:R:L61	50.2952	5.71	Yes	No	2	8	9
34	R:R:I109	R:R:S105	46.6012	3.1	Yes	Yes	2	8	8
35	L:L:?1	R:R:V72	17.4406	10.28	Yes	No	1	0	7
36	R:R:I98	R:R:V72	18.6293	4.61	Yes	No	0	5	7
37	R:R:F102	R:R:I98	11.76	6.28	Yes	Yes	0	7	5
38	L:L:?1	R:R:T168	29.7989	4.52	Yes	Yes	1	0	6
39	R:R:T168	R:R:T79	29.9266	3.14	Yes	No	1	6	7
40	R:R:T79	R:R:W85	21.4536	3.64	No	No	1	7	6
41	R:R:L91	R:R:W85	19.5947	4.56	No	No	0	6	6
42	L:L:?1	R:R:L99	37.0033	7.43	Yes	Yes	1	0	8
43	R:R:F171	R:R:L99	37.6336	7.31	Yes	Yes	1	6	8
44	R:R:F171	R:R:L100	54.4918	4.87	Yes	Yes	1	6	7
45	R:R:L100	R:R:T96	21.6691	2.95	Yes	No	0	7	7
46	R:R:S161	R:R:T96	18.3421	6.4	No	No	0	5	7
47	R:R:C92	R:R:S161	14.704	3.44	No	No	0	9	5
48	L:L:?1	R:R:W169	73.3924	10.47	Yes	Yes	1	0	5
49	R:R:F171	R:R:W169	40.6893	4.01	Yes	Yes	1	6	5
50	R:R:C170	R:R:C92	11.0499	7.28	No	No	0	9	9
51	R:R:G87	R:R:L91	15.3502	1.71	No	No	0	5	6
52	R:R:G87	R:R:G88	13.2041	2.11	No	No	0	5	5
53	R:R:G88	R:R:P90	11.042	2.03	No	No	0	5	2
54	R:R:C151	R:R:L100	11.0499	6.35	No	Yes	0	8	7
55	R:R:L100	R:R:Y184	21.709	4.69	Yes	Yes	0	7	8
56	R:R:N147	R:R:S105	45.6917	2.98	Yes	Yes	0	8	8
57	R:R:N147	R:R:S108	43.2982	5.96	Yes	No	0	8	7
58	R:R:L195	R:R:S108	41.2239	3	Yes	No	0	8	7
59	R:R:L107	R:R:L195	35.0566	2.77	No	Yes	0	8	8
60	R:R:L107	R:R:S192	32.8307	3	No	No	0	8	7
61	R:R:I110	R:R:Y329	85.9263	6.04	No	Yes	0	8	9
62	R:R:I110	R:R:T199	84.8173	3.04	No	No	0	8	8
63	R:R:C111	R:R:T199	31.4744	3.38	No	No	0	7	8
64	R:R:C111	R:R:L195	30.0223	3.17	No	Yes	0	7	8
65	R:R:S114	R:R:T199	78.9293	3.2	No	No	0	9	8
66	R:R:N203	R:R:S114	75.3391	7.45	No	No	0	9	9
67	R:R:L274	R:R:N203	73.52	5.49	Yes	No	0	8	9
68	R:R:L274	R:R:V206	67.9352	2.98	Yes	Yes	0	8	9
69	R:R:V206	R:R:Y118	22.81	3.79	Yes	Yes	5	9	8
70	R:R:H123	R:R:Y118	16.2997	4.36	No	Yes	0	7	8
71	R:R:H123	R:R:L119	14.0179	2.57	No	No	0	7	6
72	R:R:F126	R:R:L119	11.7201	1.22	No	No	0	5	6
73	R:R:Q164	R:R:W169	35.1444	25.19	Yes	Yes	1	7	5
74	R:R:Q164	R:R:R162	27.6608	5.84	Yes	No	1	7	4
75	R:R:D173	R:R:R162	23.5998	20.25	Yes	No	1	5	4
76	R:R:D173	R:R:S160	10.8026	5.89	Yes	No	1	5	3
77	R:R:D173	R:R:T176	10.8026	7.23	Yes	No	1	5	4
78	R:R:F171	R:R:W174	22.0041	7.02	Yes	Yes	1	6	5
79	R:R:P166	R:R:T168	10.4037	8.74	No	Yes	1	6	6
80	R:R:P166	R:R:W169	11.409	5.4	No	Yes	1	6	5
81	R:R:P166	R:R:Y165	18.5735	11.13	No	Yes	0	6	3
82	L:L:?1	R:R:L312	13.7307	5.3	Yes	No	1	0	6
83	R:R:L312	R:R:N309	25.6821	4.12	No	No	0	6	2
84	R:R:N309	R:R:Y165	14.4088	5.81	No	Yes	0	2	3
85	R:R:R304	R:R:Y165	10.3638	6.17	No	Yes	0	1	3
86	R:R:N295	R:R:W174	23.6477	11.3	Yes	Yes	1	6	5
87	R:R:Q164	R:R:W174	12.4063	10.95	Yes	Yes	1	7	5
88	R:R:S192	R:R:V289	30.5888	3.23	No	No	0	7	7
89	R:R:F293	R:R:V289	28.3309	2.62	No	No	0	6	7
90	R:R:F293	R:R:Y186	12.0791	3.09	No	No	0	6	5
91	R:R:A189	R:R:F293	14.4487	5.55	No	No	0	7	6
92	R:R:I323	R:R:V320	29.9665	3.07	Yes	No	0	8	5
93	R:R:C284	R:R:V320	27.7565	3.42	No	No	0	9	5
94	R:R:C284	R:R:N321	25.5306	6.3	No	No	0	9	9
95	R:R:N321	R:R:S285	23.2887	2.98	No	No	0	9	8
96	R:R:I196	R:R:S285	18.757	4.64	No	No	0	7	8
97	R:R:I196	R:R:I286	16.4672	2.94	No	No	0	7	7
98	R:R:L210	R:R:V206	38.0246	2.98	Yes	Yes	0	9	9
99	R:R:L210	R:R:M213	29.4319	2.83	Yes	No	0	9	7
100	R:R:E267	R:R:M213	20.7994	2.71	No	No	0	8	7
101	R:R:E267	R:R:H214	16.2837	12.31	No	No	0	8	5
102	R:R:N309	R:R:P310	12.5738	6.52	No	No	0	2	4
103	R:R:N295	R:R:P300	17.5842	11.4	Yes	No	0	6	1
104	R:R:P310	R:R:R291	11.5286	8.65	No	Yes	0	4	6
105	R:R:V306	R:R:Y165	13.8104	2.52	No	Yes	0	3	3
106	R:R:S19	R:R:T22	10.4755	1.6	No	No	0	1	5
107	R:R:P300	R:R:Q299	11.7361	1.58	No	No	0	1	2
108	R:R:E305	R:R:V306	10.3798	1.43	No	No	0	1	3
109	R:R:F54	R:R:V58	21.5574	9.18	No	No	0	8	8
110	R:R:L312	R:R:R316	13.587	9.72	No	Yes	1	6	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:P24	5.03	1	Yes	No	0	7	0	1
L:L:?1	R:R:V72	10.28	1	Yes	No	0	7	0	1
L:L:?1	R:R:S73	8.06	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:T76	11.3	1	Yes	No	0	8	0	1
L:L:?1	R:R:Y80	6.29	1	Yes	No	0	6	0	1
L:L:?1	R:R:L99	7.43	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:S103	5.75	1	Yes	No	0	7	0	1
L:L:?1	R:R:T168	4.52	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:W169	10.47	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:L312	5.3	1	Yes	No	0	6	0	1
L:L:?1	R:R:R316	4.66	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:S319	14.96	1	Yes	No	0	8	0	1
L:L:?1	R:R:P322	3.78	1	Yes	No	0	9	0	1
R:R:P24	R:R:V21	3.53	0	No	No	7	6	1	2
R:R:V21	R:R:Y80	16.4	0	No	No	6	6	2	1
R:R:I23	R:R:P24	3.39	0	No	No	6	7	2	1
R:R:I23	R:R:R316	6.26	0	No	Yes	6	7	2	1
R:R:M27	R:R:R316	4.96	0	No	Yes	8	7	2	1
R:R:F28	R:R:S73	9.25	0	No	Yes	6	8	2	1
R:R:D65	R:R:P322	11.27	2	Yes	No	9	9	2	1
R:R:S73	R:R:T69	3.2	0	Yes	No	8	8	1	2
R:R:I98	R:R:V72	4.61	0	Yes	No	5	7	2	1
R:R:L99	R:R:V72	4.47	1	Yes	No	8	7	1	1
R:R:P74	R:R:S73	3.56	0	No	Yes	9	8	2	1
R:R:T168	R:R:T79	3.14	1	Yes	No	6	7	1	2
R:R:T168	R:R:Y80	9.99	1	Yes	No	6	6	1	1
R:R:L99	R:R:S95	3	1	Yes	No	8	6	1	2
R:R:F171	R:R:L99	7.31	1	Yes	Yes	6	8	2	1
R:R:Q164	R:R:W169	25.19	1	Yes	Yes	7	5	2	1
R:R:F171	R:R:Q164	3.51	1	Yes	Yes	6	7	2	2
R:R:P166	R:R:T168	8.74	1	No	Yes	6	6	2	1
R:R:P166	R:R:W169	5.4	1	No	Yes	6	5	2	1
R:R:T168	R:R:W169	3.64	1	Yes	Yes	6	5	1	1
R:R:F171	R:R:W169	4.01	1	Yes	Yes	6	5	2	1
R:R:I315	R:R:W169	11.74	0	No	Yes	6	5	2	1
R:R:L312	R:R:N309	4.12	1	No	No	6	2	1	2
R:R:L312	R:R:R316	9.72	1	No	Yes	6	7	1	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8GDA_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.95
Number of Linked Nodes	252
Number of Links	276
Number of Hubs	33
Number of Links mediated by Hubs	131
Number of Communities	5
Number of Nodes involved in Communities	41
Number of Links involved in Communities	57

Path Summary
Number Of Nodes in MetaPath	111
Number Of Links MetaPath	110
Number of Shortest Paths	41808
Length Of Smallest Path	3
Average Path Length	13.2442
Length of Longest Path	30
Minimum Path Strength	1.35
Average Path Strength	5.17484
Maximum Path Strength	18.465
Minimum Path Correlation	0.7
Average Path Correlation	0.931229
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5
Average % Of Corr. Nodes	50.9354
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	40.2462
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • molecular function activator activity • phosphorus-oxygen lyase activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • adenylate cyclase activator activity • adenylate cyclase activity • cation binding • metal ion binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • biological regulation • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of biological process • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • protein localization • regulation of localization • establishment of protein localization • nitrogen compound transport • localization • cellular macromolecule localization • regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • protein transport • regulation of cellular localization • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • prostaglandin E receptor activity • prostanoid receptor activity • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • icosanoid receptor activity • prostaglandin receptor activity • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • cellular developmental process • cell development • mononuclear cell differentiation • lymphocyte activation • lymphocyte differentiation • cell activation involved in immune response • CD4-positive, alpha-beta T cell differentiation • CD4-positive, alpha-beta T cell differentiation involved in immune response • alpha-beta T cell differentiation involved in immune response • leukocyte activation • alpha-beta T cell differentiation • T cell activation involved in immune response • alpha-beta T cell activation involved in immune response • T cell activation • cell differentiation • CD4-positive, alpha-beta T cell activation • leukocyte activation involved in immune response • alpha-beta T cell activation • T cell differentiation • lymphocyte activation involved in immune response • T-helper cell differentiation • immune response • hemopoiesis • cell activation • T cell differentiation involved in immune response • immune effector process • immune system process • leukocyte differentiation • regulation of defense response • regulation of response to external stimulus • defense response • positive regulation of biological process • response to external stimulus • regulation of inflammatory response • positive regulation of response to stimulus • positive regulation of response to external stimulus • positive regulation of inflammatory response • regulation of response to stimulus • regulation of response to stress • response to stress • positive regulation of defense response • inflammatory response • regulation of cytoskeleton organization • regulation of cellular component organization • regulation of actin filament-based process • regulation of actin filament bundle assembly • cellular component biogenesis • cellular component organization • cellular component assembly • actin filament bundle organization • actin filament-based process • cellular component organization or biogenesis • stress fiber assembly • regulation of actin filament organization • actin cytoskeleton organization • actomyosin structure organization • actin filament organization • regulation of cellular component biogenesis • regulation of organelle organization • regulation of stress fiber assembly • organelle organization • contractile actin filament bundle assembly • regulation of actomyosin structure organization • regulation of actin cytoskeleton organization • actin filament bundle assembly • regulation of supramolecular fiber organization • supramolecular fiber organization • cytoskeleton organization • MAPK cascade • ERK1 and ERK2 cascade • skeletal system development • bone development • negative regulation of inflammatory response • negative regulation of response to stimulus • negative regulation of biological process • negative regulation of response to external stimulus • negative regulation of defense response • ossification • regulation of multicellular organismal process • regulation of ossification • biological process involved in interspecies interaction between organisms • response to other organism • response to external biotic stimulus • response to nematode • response to biotic stimulus • negative regulation of cellular process • cytokine production • regulation of cytokine production • negative regulation of macromolecule metabolic process • regulation of biosynthetic process • negative regulation of metabolic process • negative regulation of cytokine production • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • negative regulation of gene expression • biosynthetic process • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • regulation of macromolecule biosynthetic process • metabolic process • macromolecule metabolic process • negative regulation of multicellular organismal process • regulation of metabolic process • response to mechanical stimulus • response to abiotic stimulus • negative regulation of locomotion • regulation of cell motility • negative regulation of eosinophil migration • eosinophil migration • eosinophil extravasation • negative regulation of cellular extravasation • cellular extravasation • myeloid leukocyte migration • regulation of cell migration • cell migration • regulation of immune system process • cell motility • negative regulation of eosinophil extravasation • negative regulation of cell migration • locomotion • regulation of leukocyte migration • regulation of eosinophil extravasation • granulocyte migration • regulation of eosinophil migration • leukocyte migration • negative regulation of leukocyte migration • negative regulation of immune system process • regulation of locomotion • negative regulation of cell motility • regulation of cellular extravasation • cellular response to mechanical stimulus • cellular response to abiotic stimulus • cellular response to external stimulus • cellular response to environmental stimulus • JNK cascade • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • positive regulation of macromolecule biosynthetic process • positive regulation of metabolic process • positive regulation of biosynthetic process • positive regulation of macromolecule metabolic process • positive regulation of cellular process • positive regulation of gene expression • positive regulation of multicellular organismal process • positive regulation of cytokine production • negative regulation of cellular component organization • protein-containing complex organization • negative regulation of protein-containing complex assembly • negative regulation of integrin activation • regulation of protein-containing complex assembly • protein-containing complex assembly • regulation of integrin activation • integrin activation • response to lipopolysaccharide • response to bacterium • response to molecule of bacterial origin • G-protein beta-subunit binding • fibroblast proliferation
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	YZV
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	YZV
Name	(2S,5R)-5-[(1E,3S)-4,4-difluoro-3-hydroxy-4-phenylbut-1-en-1-yl]-1-[6-(1H-tetrazol-5-yl)hexyl]pyrrolidin-2-ol
Synonyms
Identifier
Formula	C21 H29 F2 N5 O2
Molecular Weight	421.484
SMILES
PubChem	169501698
Formal Charge	0
Total Atoms	59
Total Chiral Atoms	3
Total Bonds	61
Total Aromatic Bonds	11


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P35408
Sequence	>8GDA_nogp_Chain_R S P V T I P A V M F I F G V V G N L V A I V V L C K S R K E Q K E T T F Y T L V C G L A V T D L L G T L L V S P V T I A T Y M K G Q W P G G Q P L C E Y S T F I L L F F S L S G L S I I C A M S V E R Y L A I N H A Y F Y S H Y V D K R L A G L T L F A V Y A S N V L F C A L P N M G L G S S R L Q Y P D T W C F I D W T T N V T A H A A Y S Y M Y A G F S S F L I L A T V L C N V L V C G A L L R M H R Q F M R R T G A E I Q M V I L L I A T S L V V L I C S I P L V V R V F V N Q L Y Q P S L E R E V S K N P D L Q A I R I A S V N P I L D P W I Y I L L R K T V L S K A I E K I Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8GCP	A	Lipid	Prostanoid	EP₄	Homo sapiens	PGE2	-	Gi1/β1/γ2	3.1	2024-01-03	10.1073/pnas.2216329120
	8GCP (No Gprot)	A	Lipid	Prostanoid	EP₄	Homo sapiens	PGE2	-		3.1	2024-01-03	10.1073/pnas.2216329120
	8GCM	A	Lipid	Prostanoid	EP₄	Homo sapiens	L902688	-	Gi1/β1/γ2	3.5	2024-01-03	10.1073/pnas.2216329120
	8GCM (No Gprot)	A	Lipid	Prostanoid	EP₄	Homo sapiens	L902688	-		3.5	2024-01-03	10.1073/pnas.2216329120
	8GDB	A	Lipid	Prostanoid	EP₄	Homo sapiens	PGE2	-	Gs/β1/γ2	3.1	2024-01-03	10.1073/pnas.2216329120
	8GDB (No Gprot)	A	Lipid	Prostanoid	EP₄	Homo sapiens	PGE2	-		3.1	2024-01-03	10.1073/pnas.2216329120
	8GDA	A	Lipid	Prostanoid	EP₄	Homo sapiens	L902688	-	Gs/β1/γ2	3.3	2024-01-03	10.1073/pnas.2216329120
	8GDA (No Gprot)	A	Lipid	Prostanoid	EP₄	Homo sapiens	L902688	-		3.3	2024-01-03	10.1073/pnas.2216329120
	8GD9	A	Lipid	Prostanoid	EP₄	Homo sapiens	Rivenprost	-	Gs/β1/γ2	3.2	2024-01-03	10.1073/pnas.2216329120
	8GD9 (No Gprot)	A	Lipid	Prostanoid	EP₄	Homo sapiens	Rivenprost	-		3.2	2024-01-03	10.1073/pnas.2216329120
	7D7M	A	Lipid	Prostanoid	EP₄	Homo sapiens	Dinoprostone	-	Gs/β1/γ1	3.3	2020-11-18	10.1016/j.str.2020.11.007
	7D7M (No Gprot)	A	Lipid	Prostanoid	EP₄	Homo sapiens	Dinoprostone	-		3.3	2020-11-18	10.1016/j.str.2020.11.007
	5YWY	A	Lipid	Prostanoid	EP₄	Homo sapiens	ONO-AE3-208	-	-	3.2	2018-12-05	10.1038/s41589-018-0131-3
	5YHL	A	Lipid	Prostanoid	EP₄	Homo sapiens	PubChem 135121352	-	-	4.2	2018-12-05	10.1038/s41589-018-0131-3

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