Show 66.67 Consensus cyslt1_off_ortoallo Orthosteric Ligand 6RZ5-CysLT1 -Zafirlukast-Na 6RZ4-CysLT1 -Pranlukast-Na Show 60.00 Single 6RZ5 Zafirlukast 6RZ5-CysLT1 -Zafirlukast-Na Show 52.94 Single 6RZ7 ONO-2570366 6RZ7-CysLT2 -ONO-2570366 Show 50.00 Single 6RZ9 ONO-2770372 6RZ9-CysLT2 -ONO-2770372 Show 50.00 Consensus cyslt2_off Orthosteric Ligand 6RZ6-CysLT2 -ONO-2570366 6RZ9-CysLT2 -ONO-2770372 6RZ8-CysLT2 -ONO-2080365 Show 50.00 Consensus cyslt_off Orthosteric Ligand cyslt2_off Show 47.37 Single 6RZ6 ONO-2570366 6RZ6-CysLT2 -ONO-2570366 Show 45.00 Single 6RZ8 ONO-2080365 6RZ8-CysLT2 -ONO-2080365 Show 42.11 Single 8ID8 TUG-891 8ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 Show 41.18 Single 6ME8 2-Phenylmelatonin 6ME8-MT2 -2-Phenylmelatonin Show 40.91 Single 7XAU Octreotide 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 Show 40.00 Single 7NA7 Ghrelin-27 7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 Show 40.00 Single 7TUZ 7alpha,25-dihydroxycholesterol 7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2 Show 38.89 Single 8XBI S3E-LysoPS 8XBI-GPR34-S3E-LysoPS Show 38.10 Single 8G59 TUG-891 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 Show 38.10 Single 8XBH S3E-LysoPS 8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2 Show 37.50 Single 8HQN 9(S)-HODE 8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2 Show 36.84 Single 3VW7 Vorapaxar; Na 3VW7-PAR1-Vorapaxar; Na Show 36.84 Single 6ME6 2-Phenylmelatonin 6ME6-MT2 -2-Phenylmelatonin Show 35.71 Single 6ME9 Ramelteon 6ME9-MT2 -Ramelteon Show 35.71 Single 8F76 - 8F76-OR51E2-Gs/&β;1/&γ;2 Show 35.29 Single 7VGZ Remalteon 7VGZ-MT1 -Remalteon-Gi1/&β;1/&γ;2 Show 35.29 Consensus ffa_on Orthosteric Ligand ffa4_on ffa1_on ffa2_on ffa3_on Show 35.00 Single 8IYS TUG-891 8IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2 Show 33.33 Single 4NTJ AZD1283 4NTJ-P2Y12 -AZD1283 Show 33.33 Single 7CFN INT-777 7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 Show 33.33 Single 7VUI JNJ-63533054 7VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2 Show 33.33 Single 8IZ4 Lysophosphatidylserine 8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2 Show 32.00 Single 7F9Y Ghrelin-28 7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 Show 32.00 Single 7X9B Neuropeptide Y 7X9B-Y2 -Neuropeptide Y-Gi1/&β;1/&γ;2 Show 31.82 Single 8IZB Lysophosphatidylserine 8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2 Show 31.58 Single 4RWD DIPP-NH2 4RWD-δ-DIPP-NH2-Na Show 31.58 Single 5A8E 7-Methylcyanopindolol 5A8E-β1 -7-Methylcyanopindolol-Na Show 31.58 Single 7VGY 2-Iodomelatonin 7VGY-MT1 -2-Iodomelatonin-Gi1/&β;1/&γ;2 Show 31.58 Single 8JLP Ralmitaront 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 Show 31.58 Single 8JXV Clozapine 8JXV-H4 -Clozapine-Gi1/&β;1/&γ;2 Show 31.58 Single 8JXW VUF6884 8JXW-H4 -VUF6884-Gi1/&β;1/&γ;2 Show 31.58 Single 8X16 Piclidenoson 8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2 Show 31.25 Single 7F1O Dopamine 7F1O-D1 -Dopamine-GDP; Mg-Gs/&β;1/&γ;2 Show 31.25 Single 7VUJ JNJ-63533054 7VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2 Show 30.43 Single 4IB4 Ergotamine 4IB4-5-HT2B -Ergotamine Show 30.43 Single 7DDZ JNJ-31020028 7DDZ-Y2 -JNJ-31020028 Show 30.43 Consensus npy2_off Orthosteric Ligand 7DDZ-Y2 -JNJ-31020028 Show 30.00 Single 2YCX Cyanopindolol 2YCX-β1 -Cyanopindolol Show 30.00 Single 3D4S Timolol Maleate 3D4S-β2 -Timolol Maleate Show 30.00 Single 6OS0 Angiotensinogen 6OS0-AT1 -Angiotensinogen Show 30.00 Single 7EO4 BAF312 7EO4-S1P1 -BAF312-Gi1/&β;1/&γ;2 Show 30.00 Single 7EXD Lasmiditan 7EXD-5-HT1F -Lasmiditan-Gi1/&β;1/&γ;2 Show 30.00 Single 8WRB Lysophosphatidylserine 8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2 Show 30.00 Consensus 5ht1f_on Orthosteric Ligand 7EXD-5-HT1F -Lasmiditan-Gi1/&β;1/&γ;2 Show 30.00 Consensus go_5ht Orthosteric Ligand 6G79-5-HT1B -Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT5A -5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A -Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A -Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2 Show 29.63 Single 7YOO Neuropeptide Y 7YOO-Y2 -Neuropeptide Y-Gi1/&β;1/&γ;2 Show 29.41 Single 6ME3 2-Phenylmelatonin 6ME3-MT1 -2-Phenylmelatonin Show 29.41 Single 6PT0 WIN 55212-2 6PT0-CB2 -WIN 55212-2-Gi1/&β;1/&γ;2 Show 29.41 Single 7F0T Dopamine 7F0T-D1 -Dopamine-Gs/&β;1/&γ;2 Show 29.41 Single 7F1Z Dopamine 7F1Z-D1 -Dopamine-GDP-Gs/&β;1/&γ;2 Show 29.41 Single 7WVU fMLF 7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 Show 29.41 Single 8K4N VF0 8K4N-GPR34-VF0-Gi1/&β;1/&γ;2 Show 29.41 Consensus 5ht5_on Orthosteric Ligand 5ht5a_on Show 29.41 Consensus 5ht5a_on Orthosteric Ligand 7UM5-5-HT5A -5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A -Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A -Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2 Show 29.41 Consensus gs_tar Orthosteric Ligand 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2 Show 29.41 Consensus ox2_off Orthosteric Ligand 6TPN-OX2 -HTL6641 7XRR-OX2 -Lemborexant Show 29.03 Consensus gi_neuropeptide Orthosteric Ligand 7YOO-Y2 -Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2 -Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4 -Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1 -Neuropeptide Y-Gi1/&β;1/&γ;2 Show 29.03 Consensus npy_on Orthosteric Ligand npy2_on npy4_on npy1_on Show 28.57 Single 2YCZ Iodocyanopindolol 2YCZ-β1 -Iodocyanopindolol Show 28.57 Single 4BVN Cyanopindolol 4BVN-β1 -Cyanopindolol-Na Show 28.57 Single 4PXZ 2MeSADP 4PXZ-P2Y12 -2MeSADP Show 28.57 Single 6BQG Ergotamine 6BQG-5-HT2C -Ergotamine Show 28.57 Single 6G79 Donitriptan 6G79-5-HT1B -Donitriptan-Go/&β;1/&γ;2 Show 28.57 Single 7EVZ Cenerimod 7EVZ-S1P1 -Cenerimod-Gi1/&β;1/&γ;2 Show 28.57 Single 7EW0 Ozanimod 7EW0-S1P1 -Ozanimod-Gi1/&β;1/&γ;2 Show 28.57 Single 7UM4 AS2674723 7UM4-5-HT5A -AS2674723 Show 28.57 Single 7WVV fMLFII 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 Show 28.57 Single 7XAV Lanreotide 7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2 Show 28.57 Single 7XK2 MK6892 7XK2-HCA2 -MK6892-Gi1/&β;1/&γ;2 Show 28.57 Single 8E9X 2-Deoxycytidine 8E9X-M4 -2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 Show 28.57 Single 8FX5 Xanomeline 8FX5-M4 -Xanomeline-Xanomeline-Gi1/&β;1/&γ;2 Show 28.57 Single 8GUT LEI-102 8GUT-CB2 -LEI-102-Gi1/&β;1/&γ;2 Show 28.57 Single 8WRZ 8D0 8WRZ-CB1 -8D0-Arrestin1 Show 28.57 Consensus 5ht5a_off Orthosteric Ligand 7UM4-5-HT5A -AS2674723 Show 28.57 Consensus beta1_off_allo Orthosteric Ligand 4BVN-β1 -Cyanopindolol-Na Show 28.57 Consensus ot_on Orthosteric Ligand 7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2 Show 28.00 Single 8H4K GW9508 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 Show 28.00 Consensus ghrelin_on Orthosteric Ligand 7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2 Show 27.78 Single 2VT4 Cyanopindolol 2VT4-β1 -Cyanopindolol Show 27.78 Single 3ZPR 4-methyl-2-(piperazin-1-yl) 3ZPR-β1 -4-methyl-2-(piperazin-1-yl)-Na Show 27.78 Single 4EJ4 Naltrindole 4EJ4-δ-Naltrindole Show 27.78 Single 4X1H Nonyl Beta-D-Glucopyranoside 4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT) Show 27.78 Single 6FKC PubChem 132473039 6FKC-Rhodopsin-PubChem 132473039 Show 27.78 Single 6PS8 2-Phenylmelatonin 6PS8-MT1 -2-Phenylmelatonin Show 27.78 Single 7CRH SKF83959 7CRH-D1 -SKF83959-Gs/&β;1/&γ;2 Show 27.78 Single 7DB6 Ramelteon 7DB6-MT1 -Ramelteon-Gi1/&β;1/&γ;2 Show 27.78 Single 7JVQ Apomorphine 7JVQ-D1 -Apomorphine-Gs/&β;1/&γ;2 Show 27.78 Single 7PP1 Selatogrel 7PP1-P2Y12 -Selatogrel Show 27.78 Single 7SQO TAK-925 7SQO-OX2 -TAK-925-Gi1/&β;1/&γ;2 Show 27.78 Single 7UM6 Lisuride 7UM6-5-HT5A -Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 Show 27.78 Single 7VKT LTB4 7VKT-BLT1 -LTB4-Gi1/&β;1/&γ;2 Show 27.78 Single 7YU4 ONO-0740556 7YU4-LPA1 -ONO-0740556 Show 27.78 Single 8EJK TAK-875 8EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 Show 27.78 Single 8JLZ ST1936 8JLZ-5-HT6 -ST1936-Gs/&β;1/&γ;2 Show 27.78 Single 8WC7 ZH8667 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2 Show 27.78 Consensus 5ht6_on Orthosteric Ligand 7XTB-5-HT6 -Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6 -ST1936-Gs/&β;1/&γ;2 Show 27.78 Consensus blt1_on Orthosteric Ligand 7VKT-BLT1 -LTB4-Gi1/&β;1/&γ;2 Show 27.78 Consensus blt_on Orthosteric Ligand blt1_on Show 27.78 Consensus dop_off Orthosteric Ligand 4EJ4-δ-Naltrindole Show 27.78 Consensus gi_leukotriene Orthosteric Ligand 7VKT-BLT1 -LTB4-Gi1/&β;1/&γ;2 Show 27.78 Consensus leuko_on Orthosteric Ligand blt_on Show 27.78 Consensus nucleotide_off Orthosteric Ligand adenosine_off p2y_off Show 27.78 Consensus p2y12_off Orthosteric Ligand 4NTJ-P2Y12 -AZD1283 7PP1-P2Y12 -Selatogrel Show 27.27 Single 5ZTY AM10257 5ZTY-CB2 -AM10257 Show 27.27 Single 7F9Z GHRP-6 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 Show 27.27 Single 8H4I Doconexent 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2 Show 27.27 Single 8SAI 1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine 8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2 Show 27.27 Single 8XZF WN561 8XZF-Apelin-WN561-Gi1/&β;1/&γ;2 Show 27.27 Consensus cb2_off Orthosteric Ligand 5ZTY-CB2 -AM10257 Show 27.27 Consensus dop_on Orthosteric Ligand 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 Show 27.27 Consensus go_vasopressin Orthosteric Ligand 7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2 Show 27.27 Consensus lpl_on Orthosteric Ligand s1p_on lpa_on Show 26.92 Single 7KH0 Acyclovir triphosphate 7KH0-V2 -Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2 Show 26.92 Single 7X9C Pancreatic Hormone 7X9C-Y4 -Pancreatic Hormone-Gi1/&β;1/&γ;2 Show 26.92 Single 8HCQ Endothelin-1 8HCQ-ETA -Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 Show 26.92 Single 8KH5 Lysophosphatidylserine 8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2 Show 26.92 Consensus eta_on Orthosteric Ligand 8HCQ-ETA -Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 Show 26.92 Consensus gq_class-a Orthosteric Ligand gq_amine gq_peptide Show 26.67 Single 6FK9 PubChem 132473036 6FK9-Rhodopsin-PubChem 132473036 Show 26.67 Single 6ME5 Agomelatine 6ME5-MT1 -Agomelatine Show 26.67 Single 8EIT Doconexent 8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 Show 26.32 Single 2YCW (S)-Carazolol 2YCW-β1 -(S)-Carazolol Show 26.32 Single 5D6L (S)-Carazolol 5D6L-β2 -(S)-Carazolol Show 26.32 Single 5TVN LSD 5TVN-5-HT2B -LSD Show 26.32 Single 5XPR Bosentan 5XPR-ETB -Bosentan Show 26.32 Single 6DDE Damgo 6DDE-μ-Damgo-Gi1/&β;1/&γ;2 Show 26.32 Single 6KPC PubChem 145915889 6KPC-CB2 -PubChem 145915889 Show 26.32 Single 7EUO fMLF 7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 Show 26.32 Single 7VFX fMLF 7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 Show 26.32 Single 7VUH JNJ-63533054 7VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2 Show 26.32 Single 7YU3 ONO-0740556 7YU3-LPA1 -ONO-0740556-Gi1/&β;1/&γ;2 Show 26.32 Single 7YU6 ONO-0740556 7YU6-LPA1 -ONO-0740556-Gi1/&β;1/&γ;2 Show 26.32 Single 7YU7 ONO-0740556 7YU7-LPA1 -ONO-0740556-Gi1/&β;1/&γ;2 Show 26.32 Single 8ID9 Eicosapentaenoic acid 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 Show 26.32 Consensus adrenergic_off Orthosteric Ligand beta_off alpha_off Show 26.32 Consensus d1_on Orthosteric Ligand 7F0T-D1 -Dopamine-Gs/&β;1/&γ;2 7CKY-D1 -PW0464-Gs/&β;1/&γ;2 8IRR-D1 -Rotigotine-Gs/&β;1/&γ;2 7JV5-D1 -SKF81297-Gs/&β;1/&γ;2 7JVP-D1 -SKF83959-Gs/&β;1/&γ;2 7X2D-D1 -Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1 -VFP-Gs/&β;1/&γ;2 7CKX-D1 -A77636-Gs/&β;1/&γ;2 7JVQ-D1 -Apomorphine-Gs/&β;1/&γ;2 Show 26.32 Consensus go_amine Orthosteric Ligand go_adrenergic go_muscarinic go_5ht Show 26.09 Single 4IAR Ergotamine 4IAR-5-HT1B -Ergotamine Show 26.09 Single 5UNF PubChem 15780052 5UNF-AT2 -PubChem 15780052 Show 26.09 Single 7F4I SHU9119 7F4I-MC1 -SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 Show 26.09 Single 7T6U CGEN-855A 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 Show 26.09 Single 7TD4 Siponimod 7TD4-S1P1 -Siponimod-Gi1/&β;1/&γ;2 Show 26.09 Single 8GHV PubChem 145964903 8GHV-CB1 -PubChem 145964903-Gi1/&β;1/&γ;2 Show 26.09 Single 8J6R MK6892 8J6R-HCA2 -MK6892-Gi1/&β;1/&γ;2 Show 26.09 Consensus gi_ghrelin Orthosteric Ligand 7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2 Show 26.09 Consensus sst2_on Orthosteric Ligand 7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2 Show 25.93 Consensus npy2_on Orthosteric Ligand 7YOO-Y2 -Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2 -Peptide YY(3-36)-Gi1/&β;1/&γ;2 Show 25.93 Consensus npy4_on Orthosteric Ligand 7X9C-Y4 -Pancreatic Hormone-Gi1/&β;1/&γ;2 Show 25.00 Single 2YDV NECA 2YDV-A2A -NECA Show 25.00 Single 4IAQ Dihydroergotamine 4IAQ-5-HT1B -Dihydroergotamine Show 25.00 Single 4RWA DIPP-NH2 4RWA-δ-DIPP-NH2 Show 25.00 Single 4UHR CGS21680 4UHR-A2A -CGS21680 Show 25.00 Single 5D5A (S)-Carazolol 5D5A-β2 -(S)-Carazolol Show 25.00 Single 5D5B (S)-Carazolol 5D5B-β2 -(S)-Carazolol Show 25.00 Single 5G53 NECA 5G53-A2A -NECA-Gs Show 25.00 Single 5XR8 AM841 5XR8-CB1 -AM841 Show 25.00 Single 5XRA AM11542 5XRA-CB1 -AM11542 Show 25.00 Single 5ZHP PubChem 134828589 5ZHP-M3 -PubChem 134828589 Show 25.00 Single 6FK6 PubChem 132473033 6FK6-Rhodopsin-PubChem 132473033 Show 25.00 Single 6HLL CP99994 6HLL-NK1 -CP99994 Show 25.00 Single 6HLO Aprepitant 6HLO-NK1 -Aprepitant Show 25.00 Single 6PGS Geraniol 6PGS-Rhodopsin-Geraniol-Gt(CT) Show 25.00 Single 6PH7 Nerol 6PH7-Rhodopsin-Nerol-Gt(CT) Show 25.00 Single 6QNO All-trans-retinal 6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1 Show 25.00 Single 7EW4 CYM5541 7EW4-S1P3 -CYM5541-Gi1/&β;1/&γ;2 Show 25.00 Single 7EW7 PubChem 4077460 7EW7-S1P1 -PubChem 4077460-Gi1/&β;1/&γ;2 Show 25.00 Single 7F4F Afamelanotide 7F4F-MC1 -Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 Show 25.00 Single 7FEE PubMed 104895 7FEE-CB1 -PubMed 104895-ZCZ011 Show 25.00 Single 7JVP SKF83959 7JVP-D1 -SKF83959-Gs/&β;1/&γ;2 Show 25.00 Single 7SRQ LSD 7SRQ-5-HT2B -LSD Show 25.00 Single 7W6P W96 7W6P-α2a -W96-Go/&β;1/&γ;2 Show 25.00 Single 7W7E W58 7W7E-α2a -W58-Go/&β;1/&γ;2 Show 25.00 Single 7WJ5 Somatostatin-14 7WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 Show 25.00 Single 7WVX Humanin 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 Show 25.00 Single 7XMS Somatostatin-14 7XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2 Show 25.00 Single 7XOW Gastrin 7XOW-CCKB -Gastrin-Gq/&β;1/&γ;2 Show 25.00 Single 7XOX Cholecystokinin-8 7XOX-CCKB -Cholecystokinin-8-Gq/&β;1/&γ;2 Show 25.00 Single 7XTA Serotonin 7XTA-5-HT4 -Serotonin-Gi1/&β;1/&γ;2 Show 25.00 Single 7XTQ R399 7XTQ-GPBA-R399-Gs/&β;1/&γ;2 Show 25.00 Single 7YU5 ONO-0740556 7YU5-LPA1 -ONO-0740556-Gi1/&β;1/&γ;2 Show 25.00 Single 8DCS Cyanopindolol 8DCS-β1 -Cyanopindolol-Gs/&β;1/&γ;2 Show 25.00 Single 8F7Q Beta-endorphin 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 Show 25.00 Single 8F7S Deltorphin 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 Show 25.00 Single 8F7W Dynorphin 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 Show 25.00 Single 8GH1 Epinephrine 8GH1-β2 -Epinephrine Show 25.00 Single 8GUS HU-308 8GUS-CB2 -HU-308-Gi1/&β;1/&γ;2 Show 25.00 Single 8HPT C5a anaphylatoxin C-terminal peptide 8HPT-C5a1 -C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2 Show 25.00 Single 8I2G Compound 716340 8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2 Show 25.00 Single 8I9A EP54 8I9A-C3aB -EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 Show 25.00 Single 8ID3 9-Hydroxystearic acid 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 Show 25.00 Single 8ID6 Oleic acid 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 Show 25.00 Single 8JSO AMPH 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 Show 25.00 Consensus 5ht1b_on Orthosteric Ligand 6G79-5-HT1B -Donitriptan-Go/&β;1/&γ;2 Show 25.00 Consensus 5ht5_off Orthosteric Ligand 5ht5a_off Show 25.00 Consensus 5ht_off Orthosteric Ligand 5ht2_off 5ht5_off 5ht1_off Show 25.00 Consensus beta1_off Orthosteric Ligand 2VT4-β1 -Cyanopindolol 2YCZ-β1 -Iodocyanopindolol Show 25.00 Consensus cck_on Orthosteric Ligand ccka_on cckb_on Show 25.00 Consensus ffa4_on Orthosteric Ligand 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2 Show 25.00 Consensus gi_ffa Orthosteric Ligand 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2 Show 25.00 Consensus gi_lpl Orthosteric Ligand 7EW3-S1P3 -S1P-Gi1/&β;1/&γ;2 7TD4-S1P1 -Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1 -(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1 -BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1 -CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1 -Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3 -CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3 -Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1 -LPA-Gi1/&β;1/&γ;2 7YU3-LPA1 -ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1 -Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1 -PubChem 4077460-Gi1/&β;1/&γ;2 Show 25.00 Consensus gs_compl-peptide Orthosteric Ligand 8I9A-C3aB -EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 Show 25.00 Consensus gs_dopamine Orthosteric Ligand 7F0T-D1 -Dopamine-Gs/&β;1/&γ;2 7CKX-D1 -A77636-Gs/&β;1/&γ;2 7JVQ-D1 -Apomorphine-Gs/&β;1/&γ;2 7CKY-D1 -PW0464-Gs/&β;1/&γ;2 8IRV-D5 -Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D1 -SKF81297-Gs/&β;1/&γ;2 7JVP-D1 -SKF83959-Gs/&β;1/&γ;2 7X2D-D1 -Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1 -VFP-Gs/&β;1/&γ;2 Show 25.00 Consensus lpa1_on Orthosteric Ligand 7TD0-LPA1 -LPA-Gi1/&β;1/&γ;2 7YU3-LPA1 -ONO-0740556-Gi1/&β;1/&γ;2 Show 25.00 Consensus lpa_off Orthosteric Ligand lpa1_off Show 25.00 Consensus lpa_on Orthosteric Ligand lpa1_on Show 25.00 Consensus mt1_on Orthosteric Ligand 7VGY-MT1 -2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1 -Ramelteon-Gi1/&β;1/&γ;2 Show 25.00 Consensus npy1_on Orthosteric Ligand 7X9A-Y1 -Neuropeptide Y-Gi1/&β;1/&γ;2 Show 25.00 Consensus npy_off Orthosteric Ligand npy2_off npy1_off Show 25.00 Consensus ox1_off_allo Orthosteric Ligand 6TOD-OX1 -EMPA-Na 6TOS-OX1 -GSK1059865-Na 6TQ4-OX1 -PubChem 16046844-Na 6TO7-OX1 -Suvorexant-Na Show 24.14 Single 7VGX Neuropeptide Y 7VGX-Y1 -Neuropeptide Y-Gi1/&β;1/&γ;2 Show 24.14 Consensus gq_peptide Orthosteric Ligand gq_cck gq_angiotensin gq_bombesin gq_bradykinin Show 24.00 Single 5WF5 UK-432097 5WF5-A2A -UK-432097 Show 24.00 Single 6LW5 WKYMVm 6LW5-FPR2-ALX-WKYMVm Show 24.00 Single 7MBX Cholecystokinin-8 7MBX-CCKA -Cholecystokinin-8-Gs/&β;1/&γ;1 Show 24.00 Single 7T6T fMLFII 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 Show 24.00 Single 7TD0 LPA 7TD0-LPA1 -LPA-Gi1/&β;1/&γ;2 Show 24.00 Single 7TD2 LPA 7TD2-LPA1 -LPA-Gi1/&β;1/&γ;2 Show 24.00 Consensus angiotensin_on Orthosteric Ligand at1_on Show 24.00 Consensus at1_on Orthosteric Ligand 7F6G-AT1 -SAR1-AngII-Gq/&β;1/&γ;2 Show 24.00 Consensus gs_class-a Orthosteric Ligand gs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid Show 24.00 Consensus opioid_on Orthosteric Ligand kop_on mop_on nop_on dop_on Show 23.81 Single 4PY0 2MeSATP 4PY0-P2Y12 -2MeSATP Show 23.81 Single 4Z36 ONO-3080573 4Z36-LPA1 -ONO-3080573 Show 23.81 Single 6DRY Methylergonovine 6DRY-5-HT2B -Methylergonovine Show 23.81 Single 6H7O Cyanopindolol 6H7O-β1 -Cyanopindolol Show 23.81 Single 6HLP Netupitant 6HLP-NK1 -Netupitant Show 23.81 Single 6KPG AM841 6KPG-CB1 -AM841-Gi1/&β;1/&γ;2 Show 23.81 Single 6KQI PubMed 104895 6KQI-CB1 -PubMed 104895-ORG27569 Show 23.81 Single 6MXT Salmeterol 6MXT-β2 -Salmeterol Show 23.81 Single 7EVY Siponimod 7EVY-S1P1 -Siponimod-Gi1/&β;1/&γ;2 Show 23.81 Single 7EW2 Fingolimod 7EW2-S1P3 -Fingolimod-Gi1/&β;1/&γ;2 Show 23.81 Single 7L1U Orexin 7L1U-OX2 -Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 Show 23.81 Single 7XW5 ML109 7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2 Show 23.81 Single 7XW6 ML109 7XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2 Show 23.81 Single 7XXI 2MeSADP 7XXI-P2Y12 -2MeSADP-Gi2/&β;1/&γ;2 Show 23.81 Single 7XY7 NECA 7XY7-A2B -NECA-chim(NtGi1-Gs)/&β;1/&γ;2 Show 23.81 Single 7Y24 Octreotide 7Y24-SST2-Octreotide-Go/&β;1/&γ;2 Show 23.81 Single 8IJD MK6892 8IJD-HCA2 -MK6892-Gi1/&β;1/&γ;2 Show 23.81 Single 8IRS Rotigotine 8IRS-D2 -Rotigotine-Gi1/&β;1/&γ;2 Show 23.81 Single 8IRV Rotigotine 8IRV-D5 -Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 Show 23.81 Single 8J22 TUG-1375 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 Show 23.81 Single 8JZ7 MK6892 8JZ7-HCA2 -MK6892-Gi1/&β;1/&γ;2 Show 23.81 Single 8T3Q DHA 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 Show 23.81 Single 8WU1 KCA 8WU1-CB1 -KCA-Arrestin1 Show 23.81 Consensus cannabinoid_on Orthosteric Ligand cb1_on cb2_on Show 23.81 Consensus cb1_off_allo Orthosteric Ligand 6KQI-CB1 -PubMed 104895-ORG27569 Show 23.81 Consensus cb1_on Orthosteric Ligand 8GHV-CB1 -PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB1 -AM841-Gi1/&β;1/&γ;2 6N4B-CB1 -MDMB-Fubinaca-Gi1/&β;1/&γ;2 Show 23.81 Consensus gi_cannabinoid Orthosteric Ligand 8GUS-CB2 -HU-308-Gi1/&β;1/&γ;2 8GUT-CB2 -LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2 -Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2 -PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2 -PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2 -WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB1 -AM841-Gi1/&β;1/&γ;2 6N4B-CB1 -MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB1 -PubChem 145964903-Gi1/&β;1/&γ;2 Show 23.81 Consensus gs_amine Orthosteric Ligand gs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar Show 23.81 Consensus gs_bileacid Orthosteric Ligand 7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2 Show 23.81 Consensus gs_steroid Orthosteric Ligand gs_bileacid Show 23.81 Consensus leuko_off Orthosteric Ligand blt_off cyslt_off Show 23.81 Consensus lpa1_off Orthosteric Ligand 4Z36-LPA1 -ONO-3080573 4Z34-LPA1 -ONO-9780307 4Z35-LPA1 -ONO-9910539 7YU4-LPA1 -ONO-0740556 Show 23.81 Consensus opioid_off Orthosteric Ligand kop_off mop_off nop_off dop_off Show 23.81 Consensus peptide_off Orthosteric Ligand opioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off Show 23.81 Consensus s1p_on Orthosteric Ligand s1p3_on s1p5_on s1p1_on s1p2_on Show 23.81 Consensus tsh_on_allo Other Ligand 7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2 Show 23.53 Single 1F88 11-cis-Retinal 1F88-Rhodopsin-11-cis-Retinal Show 23.53 Single 2X72 All-trans-retinal 2X72-Rhodopsin-All-trans-retinal-Gt(CT) Show 23.53 Single 3VGA ZM241385 3VGA-A2A -ZM241385-Antibody Show 23.53 Single 5OLO Tozadenant 5OLO-A2A -Tozadenant-Na Show 23.53 Single 5WS3 EMPA 5WS3-OX2 -EMPA Show 23.53 Single 6AKX A4R 6AKX-CCR5-A4R Show 23.53 Single 6FKB PubChem 132473038 6FKB-Rhodopsin-PubChem 132473038 Show 23.53 Single 6ME2 Ramelteon 6ME2-MT1 -Ramelteon Show 23.53 Single 6NWE Octyl Beta-D-Glucopyranoside 6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT) Show 23.53 Single 6TOD EMPA 6TOD-OX1 -EMPA-Na Show 23.53 Single 7F8U Lintitript 7F8U-CCKA -Lintitript Show 23.53 Single 7LD4 Adenosine 7LD4-A1 -Adenosine-Gi2/&β;1/&γ;2 Show 23.53 Single 7SRR LSD 7SRR-5-HT2B -LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 Show 23.53 Single 7T6S PubChem 24776341 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 Show 23.53 Single 7X2F Dopamine 7X2F-D1 -Dopamine-Mevidalen-Gs/&β;1/&γ;2 Show 23.53 Single 7XRR Lemborexant 7XRR-OX2 -Lemborexant Show 23.53 Single 8EFO PZM21 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 Show 23.53 Single 8GGF Epinephrine 8GGF-β2 -Epinephrine-GTP-Gs/&β;1/&γ;2 Show 23.53 Single 8J20 Valeric acid 8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2 Show 23.53 Single 8T3S Butyric acid 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 Show 23.53 Single 8UO0 Epinephrine 8UO0-β2 -Epinephrine-GTP-Gs/&β;1/&γ;2 Show 23.53 Single 8WC4 ZH8651 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2 Show 23.53 Single 8WCA 2-Phenylethylamine 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 Show 23.53 Consensus a1_on Orthosteric Ligand 7LD4-A1 -Adenosine-Gi2/&β;1/&γ;2 Show 23.53 Consensus ffa3_on_allo Orthosteric Ligand 8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2 Show 23.53 Consensus gi_nucleotide Orthosteric Ligand 7LD4-A1 -Adenosine-Gi2/&β;1/&γ;2 Show 23.53 Consensus melatonin_on Orthosteric Ligand mt1_on mt2_on Show 23.53 Consensus orexin_off Orthosteric Ligand ox2_off ox1_off Show 23.53 Consensus p2y_off Orthosteric Ligand p2y1_off p2y12_off Show 23.08 Single 7C61 Ergotamine 7C61-5-HT1B -Ergotamine Show 23.08 Single 7F6G SAR1-AngII 7F6G-AT1 -SAR1-AngII-Gq/&β;1/&γ;2 Show 23.08 Single 7RYC Oxytocin 7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 Show 23.08 Single 7YON Peptide YY(3-36) 7YON-Y2 -Peptide YY(3-36)-Gi1/&β;1/&γ;2 Show 23.08 Single 8IHF MK6892 8IHF-HCA2 -MK6892-Gi1/&β;1/&γ;2 Show 23.08 Single 8J6I MK6892 8J6I-HCA2 -MK6892-Gi1/&β;1/&γ;2 Show 23.08 Single 8XZJ WN353 8XZJ-Apelin-WN353-Gi1/&β;1/&γ;2 Show 23.08 Consensus gi_somatostatin Orthosteric Ligand 7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2 Show 23.08 Consensus gq_angiotensin Orthosteric Ligand 7F6G-AT1 -SAR1-AngII-Gq/&β;1/&γ;2 Show 23.08 Consensus nmur2_on Orthosteric Ligand 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 Show 23.08 Consensus nmur_on Orthosteric Ligand nmur1_on nmur2_on Show 22.73 Single 4NC3 Ergotamine 4NC3-5-HT2B -Ergotamine Show 22.73 Single 4Z35 ONO-9910539 4Z35-LPA1 -ONO-9910539 Show 22.73 Single 5TZY MK8666; PubChem 127053597 5TZY-FFA1 (GPR40)-MK8666; PubChem 127053597 Show 22.73 Single 6DDF Damgo 6DDF-μ-Damgo-Gi1/&β;1/&γ;2 Show 22.73 Single 7EZC UKA 7EZC-A2A -UKA Show 22.73 Single 7MTS ADX55164 7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 Show 22.73 Single 7QVM Oxytocin 7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2 Show 22.73 Single 7X2D Tavapadon 7X2D-D1 -Tavapadon-Gs/&β;1/&γ;2 Show 22.73 Single 7YU8 ONO-0740556 7YU8-LPA1 -ONO-0740556-Gi1/&β;1/&γ;2 Show 22.73 Single 8E9Y PubChem 446603 8E9Y-M3 -PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 Show 22.73 Single 8GAG YVF 8GAG-CB1 -YVF-Gi1/&β;1/&γ;2 Show 22.73 Single 8T3O TUG-891 8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 Show 22.73 Consensus bileacid_on Orthosteric Ligand 7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2 Show 22.73 Consensus cckb_on Orthosteric Ligand 7XOW-CCKB -Gastrin-Gq/&β;1/&γ;2 7F8W-CCKB -Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCKB -Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 Show 22.73 Consensus class-a_on Orthosteric Ligand sensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on Show 22.73 Consensus ffa4_on_allo Orthosteric Ligand 8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 Show 22.73 Consensus gi_class-a Orthosteric Ligand gi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar Show 22.73 Consensus gs_cck Orthosteric Ligand 7MBX-CCKA -Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCKA -SR146131-Gs/&β;1/&γ;2 Show 22.73 Consensus s1p1_on Orthosteric Ligand 7TD3-S1P1 -S1P-Gi1/&β;1/&γ;2 7TD4-S1P1 -Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1 -(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1 -BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1 -CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1 -Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1 -Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1 -PubChem 4077460-Gi1/&β;1/&γ;2 Show 22.73 Consensus steroid_on Orthosteric Ligand bileacid_on Show 22.58 Consensus melanocortin_on Orthosteric Ligand mc2_on mc1_on mc3_on mc4_on mc5_on Show 22.22 Single 4LDO L-Epinephrine 4LDO-β2 -L-Epinephrine Show 22.22 Single 4MBS Maraviroc 4MBS-CCR5-Maraviroc Show 22.22 Single 4N6H Naltrindole 4N6H-δ-Naltrindole-Na Show 22.22 Single 4ZJC SB-674042 4ZJC-OX1 -SB-674042 Show 22.22 Single 5TE3 Octyl Beta-D-Glucopyranoside 5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside Show 22.22 Single 6DS0 Ly266097 6DS0-5-HT2B -Ly266097 Show 22.22 Single 6FK8 PubChem 132473035 6FK8-Rhodopsin-PubChem 132473035 Show 22.22 Single 6FKA PubChem 132473037 6FKA-Rhodopsin-PubChem 132473037 Show 22.22 Single 6ME4 2-Iodomelatonin 6ME4-MT1 -2-Iodomelatonin Show 22.22 Single 6PEL Citronellol 6PEL-Rhodopsin-Citronellol-Gt(CT) Show 22.22 Single 6PS4 ICI 118-551 6PS4-β2 -ICI 118-551 Show 22.22 Single 6PS5 (S)-Propranolol 6PS5-β2 -(S)-Propranolol Show 22.22 Single 6TOS GSK1059865 6TOS-OX1 -GSK1059865-Na Show 22.22 Single 6TPN HTL6641 6TPN-OX2 -HTL6641 Show 22.22 Single 6VI4 JDTic 6VI4-κ-JDTic Show 22.22 Single 7CKW Fenoldopam 7CKW-D1 -Fenoldopam-Gs/&β;1/&γ;2 Show 22.22 Single 7CKZ Dopamine 7CKZ-D1 -Dopamine-Mevidalen-Gs/&β;1/&γ;2 Show 22.22 Single 7CMU Pramipexole 7CMU-D3 -Pramipexole-Gi1/&β;1/&γ;2 Show 22.22 Single 7JOZ VFP 7JOZ-D1 -VFP-Gs/&β;1/&γ;2 Show 22.22 Single 7RAN PubChem 164575847 7RAN-5-HT2A -PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 Show 22.22 Single 7SR8 TAK-925 7SR8-OX2 -TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 Show 22.22 Single 7UM7 Methylergometrine 7UM7-5-HT5A -Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2 Show 22.22 Single 7UTZ PubChem 644078 7UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2 Show 22.22 Single 7XAT Somatostatin-14 7XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 Show 22.22 Single 7XOV SR146131 7XOV-CCKA -SR146131-Gs/&β;1/&γ;2 Show 22.22 Single 7YK6 PubChem 138319674 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2 Show 22.22 Single 7YKD Chemerin-9 7YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2 Show 22.22 Single 8DPG Psilocin 8DPG-5-HT2C -Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 Show 22.22 Single 8GEG Epinephrine 8GEG-β2 -Epinephrine-Gs/&β;1/&γ;2 Show 22.22 Single 8GG5 Epinephrine 8GG5-β2 -Epinephrine-GTP-Gs/&β;1/&γ;2 Show 22.22 Single 8GGK Epinephrine 8GGK-β2 -Epinephrine Show 22.22 Single 8GGM Epinephrine 8GGM-β2 -Epinephrine Show 22.22 Single 8GGP Epinephrine 8GGP-β2 -Epinephrine Show 22.22 Single 8GGQ Epinephrine 8GGQ-β2 -Epinephrine Show 22.22 Single 8GUQ Olorinab 8GUQ-CB2 -Olorinab-Gi1/&β;1/&γ;2 Show 22.22 Single 8GUR PubChem 104895 8GUR-CB2 -PubChem 104895-Gi1/&β;1/&γ;2 Show 22.22 Single 8THL Epinephrine 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 Show 22.22 Single 8UNZ Epinephrine 8UNZ-β2 -Epinephrine-GTP-Gs/&β;1/&γ;2 Show 22.22 Single 8UO2 Epinephrine 8UO2-β2 -Epinephrine-GTP-Gs/&β;1/&γ;2 Show 22.22 Single 8WPG Tryptophan; Cinacalcet; PO4; Ca 8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca Show 22.22 Consensus d1_on_allo Orthosteric Ligand 7LJC-D1 -PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1 -Dopamine-Mevidalen-Gs/&β;1/&γ;2 Show 22.22 Consensus d3_on Orthosteric Ligand 8IRT-D3 -Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3 -PD128907-Gi1/&β;1/&γ;2 7CMU-D3 -Pramipexole-Gi1/&β;1/&γ;2 Show 22.22 Consensus dop_off_allo Orthosteric Ligand 4N6H-δ-Naltrindole-Na Show 22.22 Consensus ffa2_on Orthosteric Ligand 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 Show 22.22 Consensus gi_melatonin Orthosteric Ligand 7VGY-MT1 -2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1 -Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2 -Ramelteon-Gi1/&β;1/&γ;1 Show 22.22 Consensus gs_ghrelin Orthosteric Ligand 7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 Show 22.22 Consensus gs_neuromedin Orthosteric Ligand 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 Show 22.22 Consensus ox1_off Orthosteric Ligand 6TOT-OX1 -Lemborexant 6TP4-OX1 -ACT-462206 6TP6-OX1 -Filorexant 6V9S-OX1 -GTPL11403 6TP3-OX1 -Nemorexant 6TQ6-OX1 -PubChem 145714283 6TQ7-OX1 -SB-334867 6TQ9-OX1 -SB-408124 4ZJC-OX1 -SB-674042 4ZJ8-OX1 -Suvorexant Show 21.74 Single 3NY9 PubChem 913103 3NY9-β2 -PubChem 913103 Show 21.74 Single 4UG2 CGS21680 4UG2-A2A -CGS21680 Show 21.74 Single 5WF6 UK-432097 5WF6-A2A -UK-432097 Show 21.74 Single 6PT3 DPI-287 6PT3-δ-DPI-287 Show 21.74 Single 7F8W Gastrin-17 7F8W-CCKB -Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 Show 21.74 Single 7XN9 L-054,522 7XN9-SST2-L-054,522 Show 21.74 Single 7XY6 PubChem 11717831 7XY6-A2B -PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2 Show 21.74 Single 7Y1F Dynorphin 7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2 Show 21.74 Single 8IA7 Cholecystokinin-8 8IA7-CCKB -Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 Show 21.74 Single 8IYH MK6892 8IYH-HCA2 -MK6892-Go/&β;1/&γ;2 Show 21.74 Single 8JLR A77636 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 Show 21.74 Consensus chemokine_on Orthosteric Ligand cxcr_on cx3cr_on Show 21.74 Consensus fpr1-alx_on Orthosteric Ligand 7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 Show 21.74 Consensus gi_lipid Orthosteric Ligand gi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene Show 21.74 Consensus gq_cck Orthosteric Ligand 8IA7-CCKB -Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCKB -Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCKA -Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCKB -Gastrin-Gq/&β;1/&γ;2 Show 21.74 Consensus lpl_off Orthosteric Ligand s1p_off lpa_off Show 21.74 Consensus ox2_on Orthosteric Ligand 7L1V-OX2 -PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX2 -Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2 -TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 Show 21.43 Single 5MZJ Theophylline 5MZJ-A2A -Theophylline-Na Show 21.43 Single 7F8V Gastrin-17 7F8V-CCKB -Gastrin-17-Gi2/&β;1/&γ;2 Show 21.43 Single 7SK4 CXCL12_LRHQ 7SK4-ACKR3-CXCL12_LRHQ Show 21.43 Single 7W57 Neuromedin-S 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 Show 21.43 Single 8PWN Theophylline 8PWN-A2A -Theophylline Show 21.43 Consensus gi_neuromedin Orthosteric Ligand 7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2 Show 21.43 Consensus gs_vasopressin-ot Orthosteric Ligand 7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2 -Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2 Show 21.43 Consensus kop_on Orthosteric Ligand 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 Show 21.21 Single 7X9A Neuropeptide Y 7X9A-Y1 -Neuropeptide Y-Gi1/&β;1/&γ;2 Show 21.21 Consensus mc2_on Orthosteric Ligand 8GY7-MC2 -Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1 Show 21.05 Single 2Y02 Carmoterol 2Y02-β1 -Carmoterol Show 21.05 Single 2YCY Cyanopindolol 2YCY-β1 -Cyanopindolol Show 21.05 Single 3NY8 ICI 118-551 3NY8-β2 -ICI 118-551 Show 21.05 Single 3ZPQ 4-(piperazin-1- yl)-1H-indole 3ZPQ-β1 -4-(piperazin-1- yl)-1H-indole-Na Show 21.05 Single 4GBR (S)-Carazolol 4GBR-β2 -(S)-Carazolol Show 21.05 Single 4J4Q Octyl Beta-D-Glucopyranoside 4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT) Show 21.05 Single 4QIM PubChem 24905375 4QIM-SMO-PubChem 24905375 Show 21.05 Single 5JQH (S)-Carazolol 5JQH-β2 -(S)-Carazolol Show 21.05 Single 5ZKP Foropafant (SR27417) 5ZKP-PAF-Foropafant (SR27417) Show 21.05 Single 6DRX Lisuride 6DRX-5-HT2B -Lisuride Show 21.05 Single 6DRZ Methysergide 6DRZ-5-HT2B -Methysergide Show 21.05 Single 6FK7 PubChem 132473034 6FK7-Rhodopsin-PubChem 132473034 Show 21.05 Single 6K42 Dexmedetomidine 6K42-α2b -Dexmedetomidine-Gi1/&β;1/&γ;2 Show 21.05 Single 6KPF PubChem 145915889 6KPF-CB2 -PubChem 145915889-Gi1/&β;1/&γ;2 Show 21.05 Single 6PRZ (S)-Alprenolol 6PRZ-β2 -(S)-Alprenolol Show 21.05 Single 6PS0 (S)-Carazolol 6PS0-β2 -(S)-Carazolol Show 21.05 Single 6PS2 (S)-Alprenolol 6PS2-β2 -(S)-Alprenolol Show 21.05 Single 6XBM 25(S)-Epoxycholesterol 6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2 Show 21.05 Single 7BTS L-Epinephrine 7BTS-β1 -L-Epinephrine Show 21.05 Single 7BU6 L-Norepinephrine 7BU6-β1 -L-Norepinephrine Show 21.05 Single 7BU7 BI167107 7BU7-β1 -BI167107 Show 21.05 Single 7EPF NAM597 7EPF-mGlu2; mGlu2-NAM597 Show 21.05 Single 7LJC PubChem 86764103 7LJC-D1 -PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 Show 21.05 Single 7NA8 PubChem 178024 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2 Show 21.05 Single 7S0G Isoprenaline 7S0G-β1 -Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2 Show 21.05 Single 7T6V fMLFII 7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2 Show 21.05 Single 7UM5 5-CT 7UM5-5-HT5A -5-CT-chim(NtGi1-Go)/&β;1/&γ;2 Show 21.05 Single 7V3Z PubMed 104895 7V3Z-CB1 -PubMed 104895 Show 21.05 Single 7VH0 Ramelteon 7VH0-MT2 -Ramelteon-Gi1/&β;1/&γ;1 Show 21.05 Single 7X2C Fenoldopam 7X2C-D1 -Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2 Show 21.05 Single 7YK7 DC591053 7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 Show 21.05 Single 8GE3 Epinephrine 8GE3-β2 -Epinephrine-Gs/&β;1/&γ;2 Show 21.05 Single 8GEE Epinephrine 8GEE-β2 -Epinephrine-Gs/&β;1/&γ;2 Show 21.05 Single 8GEH Epinephrine 8GEH-β2 -Epinephrine-Gs/&β;1/&γ;2 Show 21.05 Single 8GFW Epinephrine 8GFW-β2 -Epinephrine-GTP-Gs/&β;1/&γ;2 Show 21.05 Single 8GFX Epinephrine 8GFX-β2 -Epinephrine-GTP-Gs/&β;1/&γ;2 Show 21.05 Single 8GFY Epinephrine 8GFY-β2 -Epinephrine-GTP-Gs/&β;1/&γ;2 Show 21.05 Single 8GFZ Epinephrine 8GFZ-β2 -Epinephrine-GTP-Gs/&β;1/&γ;2 Show 21.05 Single 8GG0 Epinephrine 8GG0-β2 -Epinephrine-GTP-Gs/&β;1/&γ;2 Show 21.05 Single 8GG1 Epinephrine 8GG1-β2 -Epinephrine-GTP-Gs/&β;1/&γ;2 Show 21.05 Single 8GG2 Epinephrine 8GG2-β2 -Epinephrine-GTP-Gs/&β;1/&γ;2 Show 21.05 Single 8GG6 Epinephrine 8GG6-β2 -Epinephrine-GTP-Gs/&β;1/&γ;2 Show 21.05 Single 8GGB Epinephrine 8GGB-β2 -Epinephrine-GTP-Gs/&β;1/&γ;2 Show 21.05 Single 8GGJ Epinephrine 8GGJ-β2 -Epinephrine Show 21.05 Single 8GGN Epinephrine 8GGN-β2 -Epinephrine Show 21.05 Single 8GGO Epinephrine 8GGO-β2 -Epinephrine Show 21.05 Single 8GGU Epinephrine 8GGU-β2 -Epinephrine Show 21.05 Single 8ID4 Linoleic acid 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 Show 21.05 Single 8IRT Rotigotine 8IRT-D3 -Rotigotine-Gi1/&β;1/&γ;2 Show 21.05 Single 8JLJ T1AM 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2 Show 21.05 Single 8SZH Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW 8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2 Show 21.05 Single 8UNN Epinephrine 8UNN-β2 -Epinephrine-GTP-Gs/&β;1/&γ;2 Show 21.05 Single 8UNP Epinephrine 8UNP-β2 -Epinephrine-GTP-Gs/&β;1/&γ;2 Show 21.05 Single 8W87 METH 8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 Show 21.05 Single 8X17 Namodenoson 8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2 Show 21.05 Consensus adrenergic_on Orthosteric Ligand beta_on alpha_on Show 21.05 Consensus alpha2_on Orthosteric Ligand alpha2a_on alpha2b_on Show 21.05 Consensus alpha_on Orthosteric Ligand alpha1_on alpha2_on Show 21.05 Consensus dopamine_on Orthosteric Ligand d3_on d2_on d5_on d1_on Show 21.05 Consensus fsh_on_allo Other Ligand 8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2 Show 21.05 Consensus gi_5ht Orthosteric Ligand 7E2Y-5-HT1A -Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT1A -Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT1D -Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT1E -BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT1F -Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT4 -Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT5A -5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT1A -Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A -SEP-363856-Gi1/&β;1/&γ;2 Show 21.05 Consensus lipid_off Orthosteric Ligand cannabinoid_off leuko_off lpl_off paf_off prostanoid_off Show 21.05 Consensus paf_off Orthosteric Ligand 5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417) Show 21.05 Consensus tar_on Orthosteric Ligand ta1_on Show 20.83 Single 4AMJ (S)-Carvedilol 4AMJ-β1 -(S)-Carvedilol Show 20.83 Single 7F8X NN9056 7F8X-CCKA -NN9056 Show 20.83 Single 7W0P Elabela 7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 Show 20.83 Single 7W53 Neuromedin-U-25 7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 Show 20.83 Single 7WKD TRH 7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 Show 20.83 Single 7WVW fMYFINILTL 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 Show 20.83 Single 8F7X Nociceptin 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 Show 20.83 Consensus apelin_on Orthosteric Ligand 7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2 Show 20.83 Consensus fpr-alx_on Orthosteric Ligand fpr1-alx_on fpr2-alx_on Show 20.83 Consensus gi_opioid Orthosteric Ligand 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2 Show 20.83 Consensus go_class-a Orthosteric Ligand go_amine go_peptide go_protein Show 20.83 Consensus mop_off Orthosteric Ligand 7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E Show 20.83 Consensus nop_on Orthosteric Ligand 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 Show 20.83 Consensus sst_on Orthosteric Ligand sst2_on sst4_on Show 20.69 Single 7F53 Alpha-MSH 7F53-MC4 -Alpha-MSH-Gs/&β;1/&γ;2 Show 20.69 Single 7XK8 Neuromedin-U-25 7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2 Show 20.69 Consensus endothelin_on Orthosteric Ligand etb_on eta_on Show 20.00 Single 2RH1 (S)-Carazolol 2RH1-β2 -(S)-Carazolol Show 20.00 Single 3QAK UK-432097 3QAK-A2A -UK-432097 Show 20.00 Single 4PHU Fasiglifam 4PHU-FFA1 (GPR40)-Fasiglifam Show 20.00 Single 4ZJ8 Suvorexant 4ZJ8-OX1 -Suvorexant Show 20.00 Single 5C1M BU72 5C1M-μ-BU72 Show 20.00 Single 5N2R PubChem 92460631; psb36 5N2R-A2A -PubChem 92460631; psb36-Na Show 20.00 Single 5N2S PSB36 5N2S-A1 -PSB36 Show 20.00 Single 5NM2 ZM241385 5NM2-A2A -ZM241385-Na Show 20.00 Single 5WQC EMPA 5WQC-OX2 -EMPA Show 20.00 Single 5X7D (S)-Carazolol 5X7D-β2 -(S)-Carazolol-PubChem 129318963 Show 20.00 Single 5ZBQ UR-MK-299 5ZBQ-Y1 -UR-MK-299 Show 20.00 Single 6E67 BI167107 6E67-β2 -BI167107-Gs (fused) Show 20.00 Single 6IGL IRL1620 6IGL-ETB -IRL1620 Show 20.00 Single 6KUW PubChem 57213234 6KUW-α2c -PubChem 57213234 Show 20.00 Single 6ME7 2-Phenylmelatonin 6ME7-MT2 -2-Phenylmelatonin Show 20.00 Single 6OT0 25(S)-Epoxycholesterol 6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2 Show 20.00 Single 6PS3 (S)-Carvedilol 6PS3-β2 -(S)-Carvedilol Show 20.00 Single 6PS6 Timolol 6PS6-β2 -Timolol Show 20.00 Single 6TO7 Suvorexant 6TO7-OX1 -Suvorexant-Na Show 20.00 Single 6TP6 Filorexant 6TP6-OX1 -Filorexant Show 20.00 Single 6TQ9 SB-408124 6TQ9-OX1 -SB-408124 Show 20.00 Single 6W2X PubChem 23727970 6W2X-GABAB1 , GABAB2 -PubChem 5311042-PubChem 23727970 Show 20.00 Single 6XBK Cholesterol 6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2 Show 20.00 Single 7BVQ (S)-Carazolol 7BVQ-β1 -(S)-Carazolol Show 20.00 Single 7CKX A77636 7CKX-D1 -A77636-Gs/&β;1/&γ;2 Show 20.00 Single 7CUM Phospholipid 7CUM-GABAB1 , GABAB2 -CGP54626-Phospholipid Show 20.00 Single 7LD3 Adenosine 7LD3-A1 -Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2 Show 20.00 Single 7PIU Setmelanotide 7PIU-MC4 -Setmelanotide-Gs/&β;1/&γ;2 Show 20.00 Single 7S0F Isoprenaline 7S0F-β1 -Isoprenaline-Gi1/&β;1/&γ;2 Show 20.00 Single 7SBF PZM21 7SBF-μ-PZM21-Gi1/&β;1/&γ;2 Show 20.00 Single 7TD3 S1P 7TD3-S1P1 -S1P-Gi1/&β;1/&γ;2 Show 20.00 Single 7VDM Substance P 7VDM-MRGPRX2-Substance P-Gi1/&β;1/&γ;2 Show 20.00 Single 7W0N Elabela 7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2 Show 20.00 Single 7WC6 LSD 7WC6-5-HT2A -LSD Show 20.00 Single 7XBX CX3CL1 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 Show 20.00 Single 7XKA Epinephrine 7XKA-β2 -Epinephrine Show 20.00 Single 7Y26 Octreotide 7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 Show 20.00 Single 7Y27 Somatostatin-14 7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 Show 20.00 Single 8A2O Theophylline 8A2O-A2A -Theophylline-Na Show 20.00 Single 8DZQ momSalB 8DZQ-κ-momSalB-Go/&β;1/&γ;2 Show 20.00 Single 8DZR GR89,696 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 Show 20.00 Single 8GNE KW-6356 8GNE-A2A -KW-6356-Na Show 20.00 Single 8IBV Motilin 8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 Show 20.00 Single 8IY5 Endothelin-1 8IY5-ETB -Endothelin-1-Gi1/&β;1/&γ;2 Show 20.00 Single 8K8J Fenofibrate 8K8J-CB1 -Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2 Show 20.00 Single 8QOT Nanobody E 8QOT-μ-Nanobody E Show 20.00 Single 8SZG Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW 8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2 Show 20.00 Single 8UNY Epinephrine 8UNY-β2 -Epinephrine-GTP-Gs/&β;1/&γ;2 Show 20.00 Single 9AYF Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4 9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2 Show 20.00 Consensus 5ht1_on Orthosteric Ligand 5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on Show 20.00 Consensus 5ht2b_off Orthosteric Ligand 6DRZ-5-HT2B -Methysergide 6DRX-5-HT2B -Lisuride Show 20.00 Consensus a1_off Orthosteric Ligand 5UEN-A1 -DU172 5N2S-A1 -PSB36 Show 20.00 Consensus a1_on_allo Orthosteric Ligand 7LD3-A1 -Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2 Show 20.00 Consensus alpha2a_on Orthosteric Ligand 7EJ0-α2a -L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a -Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a -W58-Go/&β;1/&γ;2 7W6P-α2a -W96-Go/&β;1/&γ;2 7EJ8-α2a -Brimonidine-Go/&β;1/&γ;2 7EJA-α2a -Dexmedetomidine-Go/&β;1/&γ;2 Show 20.00 Consensus alpha2c_off Orthosteric Ligand 6KUW-α2c -PubChem 57213234 Show 20.00 Consensus amine_off Orthosteric Ligand adrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off Show 20.00 Consensus beta2_off Orthosteric Ligand 6PS2-β2 -(S)-Alprenolol 6PS3-β2 -(S)-Carvedilol 6PS5-β2 -(S)-Propranolol 6PS6-β2 -Timolol 2RH1-β2 -(S)-Carazolol 6PS4-β2 -ICI 118-551 3NY9-β2 -PubChem 913103 Show 20.00 Consensus beta2_on Orthosteric Ligand 3SN6-β2 -BI167107-Gs/&β;1/&γ;2 7DHR-β2 -Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β2 -Arformoterol-Gs/&β;1/&γ;2 7DHI-β2 -Salbutamol-Gs/&β;1/&γ;2 Show 20.00 Consensus beta3_on Orthosteric Ligand 7DH5-β3 -Mirabegron-Gs/&β;1/&γ;2 7XJH-β3 -Isoproterenol-Gs/&β;1/&γ;2 Show 20.00 Consensus beta_off Orthosteric Ligand beta1_off beta2_off Show 20.00 Consensus cb2_on Orthosteric Ligand 8GUS-CB2 -HU-308-Gi1/&β;1/&γ;2 8GUT-CB2 -LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2 -Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2 -PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2 -PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2 -WIN 55212-2-Gi1/&β;1/&γ;2 Show 20.00 Consensus crf1_on Orthosteric Ligand 6P9X-CRF1 -Corticoliberin-Gs/&β;1/&γ;2 Show 20.00 Consensus cx3cr_on Orthosteric Ligand cx3cr1_on Show 20.00 Consensus gi_adrenergic Orthosteric Ligand 7S0F-β1 -Isoprenaline-Gi1/&β;1/&γ;2 6K42-α2b -Dexmedetomidine-Gi1/&β;1/&γ;2 Show 20.00 Consensus gi_cck Orthosteric Ligand 7EZH-CCKA -Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCKB -Gastrin-17-Gi2/&β;1/&γ;2 Show 20.00 Consensus go_opioid Orthosteric Ligand 8DZQ-κ-momSalB-Go/&β;1/&γ;2 Show 20.00 Consensus gs_adrenergic Orthosteric Ligand 3SN6-β2 -BI167107-Gs/&β;1/&γ;2 7DHR-β2 -Isoprenaline-Gs/&β;1/&γ;2 7DHI-β2 -Salbutamol-Gs/&β;1/&γ;2 7XJH-β3 -Isoproterenol-Gs/&β;1/&γ;2 7DH5-β3 -Mirabegron-Gs/&β;1/&γ;2 7XJI-β3 -Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β1 -Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1 -Dobutamine-Gs/&β;1/&γ;2 7BZ2-β2 -Arformoterol-Gs/&β;1/&γ;2 Show 20.00 Consensus gs_endothelin Orthosteric Ligand 8HCQ-ETA -Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB -Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 Show 20.00 Consensus gs_peptide Orthosteric Ligand gs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin Show 20.00 Consensus gs_sst Orthosteric Ligand 7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 Show 20.00 Consensus peptide_on Orthosteric Ligand opioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on Show 20.00 Consensus rxfp4_on Orthosteric Ligand 7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2 Show 20.00 Consensus ta1_on Orthosteric Ligand 8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 Show 20.00 Consensus vasopressin-ot_on Orthosteric Ligand ot_on v2_on Show 19.35 Single 5GLH Endothelin-1 5GLH-ETB -Endothelin-1 Show 19.35 Consensus gi_peptide Orthosteric Ligand gi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck Show 19.23 Single 3OE0 CVX15 3OE0-CXCR4-CVX15 Show 19.23 Single 6PT2 KGCHM07 6PT2-δ-KGCHM07 Show 19.23 Single 6W25 SHU9119 6W25-MC4 -SHU9119-Ca Show 19.23 Single 7O7F (6P4)CCL5 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 Show 19.23 Single 7W55 Neuromedin-U-25 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 Show 19.23 Single 7XOU Cholecystokinin-8 7XOU-CCKA -Cholecystokinin-8-Gs/&β;1/&γ;2 Show 19.23 Single 8XZG Apelin-13 8XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2 Show 19.23 Consensus cx3cr1_on Orthosteric Ligand 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 Show 19.23 Consensus gi_formylpeptide Orthosteric Ligand 7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2 Show 19.05 Single 3P0G BI167107 3P0G-β2 -BI167107 Show 19.05 Single 3PDS Hydroxybenzylisoproterenol 3PDS-β2 -Hydroxybenzylisoproterenol Show 19.05 Single 3SN6 BI167107 3SN6-β2 -BI167107-Gs/&β;1/&γ;2 Show 19.05 Single 4DJH JDTic 4DJH-κ-JDTic Show 19.05 Single 4U15 Tiotropium 4U15-M3 -Tiotropium Show 19.05 Single 4Z34 ONO-9780307 4Z34-LPA1 -ONO-9780307 Show 19.05 Single 5TZR - 5TZR-FFA1 (GPR40)-MK8666 Show 19.05 Single 5X93 K-8794 5X93-ETB -K-8794 Show 19.05 Single 6GT3 Imaradenant 6GT3-A2A -Imaradenant-Na Show 19.05 Single 6H7J Isoprenaline 6H7J-β1 -Isoprenaline Show 19.05 Single 6J21 Aprepitant 6J21-NK1 -Aprepitant Show 19.05 Single 6KO5 PubChem 57400002 6KO5-Ghrelin-PubChem 57400002 Show 19.05 Single 6N48 BI167107 6N48-β2 -BI167107-PubChem 138454256 Show 19.05 Single 6NI3 BI167107 6NI3-β2 -BI167107-Gs/&β;1/&γ;2 Show 19.05 Single 6OL9 Tiotropium 6OL9-M5 -Tiotropium Show 19.05 Single 6TQ7 SB-334867 6TQ7-OX1 -SB-334867 Show 19.05 Single 6WGT LSD 6WGT-5-HT2A -LSD Show 19.05 Single 7CKY PW0464 7CKY-D1 -PW0464-Gs/&β;1/&γ;2 Show 19.05 Single 7EW1 Siponimod 7EW1-S1P5 -Siponimod-Gi1/&β;1/&γ;2 Show 19.05 Single 7JJO Isoprenaline 7JJO-β1 -Isoprenaline-Gs/&β;1/&γ;2 Show 19.05 Single 7JV5 SKF81297 7JV5-D1 -SKF81297-Gs/&β;1/&γ;2 Show 19.05 Single 7R0C Acyclovir triphosphate 7R0C-V2 -Acyclovir triphosphate-Arrestin2 Show 19.05 Single 7TD1 LPA 7TD1-LPA1 -LPA-Gi1/&β;1/&γ;2 Show 19.05 Single 7TUY GSK682753A 7TUY-GPR183-GSK682753A Show 19.05 Single 7VIG CBP-307 7VIG-S1P1 -CBP-307-Gi1/&β;1/&γ;2 Show 19.05 Single 7W41 PD176252 7W41-BB2 -PD176252 Show 19.05 Single 7WV9 PubMed 104895 7WV9-CB1 -PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2 Show 19.05 Single 8E0G BU72 8E0G-μ-BU72 Show 19.05 Single 8HDO BAY 60-6583 8HDO-A2B -BAY 60-6583-Gs/&β;1/&γ;2 Show 19.05 Single 8HQC C5a anaphylatoxin 8HQC-C5a1 -C5a anaphylatoxin-Go/&β;1/&γ;2 Show 19.05 Single 8IRR Rotigotine 8IRR-D1 -Rotigotine-Gs/&β;1/&γ;2 Show 19.05 Single 8IRU Rotigotine 8IRU-D4 -Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2 Show 19.05 Single 8JXX Clobenpropit 8JXX-H4 -Clobenpropit-Gi1/&β;1/&γ;2 Show 19.05 Single 8WPU Tryptophan; Cinacalcet; PO4; Ca 8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 Show 19.05 Consensus a2_on Orthosteric Ligand a2a_on a2b_on Show 19.05 Consensus a2b_on Orthosteric Ligand 8HDP-A2B -Adenosine-Gs/&β;1/&γ;2 8HDO-A2B -BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B -NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B -PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2 Show 19.05 Consensus angiotensin_off Orthosteric Ligand at1_off at2_off Show 19.05 Consensus arrestin2 Orthosteric Ligand 6TKO-β1 -Arformoterol-Arrestin2 6PWC-NTS1 -Neurotensin-Arrestin2 7R0C-V2 -Acyclovir triphosphate-Arrestin2 Show 19.05 Consensus bb2_off Orthosteric Ligand 7W41-BB2 -PD176252 Show 19.05 Consensus bombesin_off Orthosteric Ligand bb2_off Show 19.05 Consensus ccka_on Orthosteric Ligand 7EZH-CCKA -Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCKA -SR146131-Gs/&β;1/&γ;2 Show 19.05 Consensus class-a_off Orthosteric Ligand sensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off Show 19.05 Consensus dopamine_off Orthosteric Ligand d3_off d2_off d4_off Show 19.05 Consensus gi_amine Orthosteric Ligand gi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine Show 19.05 Consensus gi_dopamine Orthosteric Ligand 8IRT-D3 -Rotigotine-Gi1/&β;1/&γ;2 7JVR-D2 -Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2 -Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3 -PD128907-Gi1/&β;1/&γ;2 7CMU-D3 -Pramipexole-Gi1/&β;1/&γ;2 Show 19.05 Consensus go_adrenergic Orthosteric Ligand 7EJ0-α2a -L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a -Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a -W58-Go/&β;1/&γ;2 7W6P-α2a -W96-Go/&β;1/&γ;2 6K41-α2b -Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α2a -Brimonidine-Go/&β;1/&γ;2 7EJA-α2a -Dexmedetomidine-Go/&β;1/&γ;2 Show 19.05 Consensus gs_adenosine Orthosteric Ligand 8HDP-A2B -Adenosine-Gs/&β;1/&γ;2 8HDO-A2B -BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A -NECA-Gs/&β;1/&γ;1 7XY7-A2B -NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B -PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2 Show 19.05 Consensus gs_ffa Orthosteric Ligand 8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP4 -Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4 -L902688-Gs/&β;1/&γ;2 8GDB-EP4 -PGE2-Gs/&β;1/&γ;2 Show 19.05 Consensus gs_nucleotide Orthosteric Ligand gs_adenosine Show 19.05 Consensus h1_off Orthosteric Ligand 3RZE-H1 -Cidoxepin 8X5Y-H1 -Astemizole 8X63-H1 -Mepyramine 8X64-H1 -Desloratadine Show 19.05 Consensus histamine_off Orthosteric Ligand h1_off Show 19.05 Consensus kop_off Orthosteric Ligand 4DJH-κ-JDTic Show 19.05 Consensus m3_off Orthosteric Ligand 4U15-M3 -Tiotropium 4U16-M3 -N-Methyl Scopolamine 5ZHP-M3 -PubChem 134828589 Show 19.05 Consensus m5_off Orthosteric Ligand 6OL9-M5 -Tiotropium Show 19.05 Consensus nk1_off Orthosteric Ligand 6J20-NK1 -Aprepitant 6HLL-NK1 -CP99994 6E59-NK1 -L-760735 Show 19.05 Consensus npy1_off Orthosteric Ligand 5ZBH-Y1 -BMS-193885 5ZBQ-Y1 -UR-MK-299 Show 19.05 Consensus relaxin_on Orthosteric Ligand rxfp4_on Show 19.05 Consensus s1p2_on Orthosteric Ligand 7T6B-S1P2 -S1P-chim(NtGi1L-G13)/&β;1/&γ;2 Show 19.05 Consensus s1p3_on Orthosteric Ligand 7EW3-S1P3 -S1P-Gi1/&β;1/&γ;2 7EW4-S1P3 -CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3 -Fingolimod-Gi1/&β;1/&γ;2 Show 19.05 Consensus s1p5_on Orthosteric Ligand 7EW1-S1P5 -Siponimod-Gi1/&β;1/&γ;2 Show 18.75 Single 5WKT Octyl Beta-D-Glucopyranoside 5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT) Show 18.75 Single 6FUF All-trans-retinal 6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2 Show 18.75 Single 7F23 Dopamine 7F23-D1 -Dopamine-GDP-Gs/&β;1/&γ;2 Show 18.75 Single 7S8O (R)-Zinc-3573 7S8O-MRGPRX2-(R)-Zinc-3573-Gi1/&β;1/&γ;2 Show 18.75 Single 8GGR Epinephrine 8GGR-β2 -Epinephrine Show 18.75 Single 8GGZ Epinephrine 8GGZ-β2 -Epinephrine Show 18.75 Single 8J21 Butyric acid 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2 Show 18.75 Single 8J24 Acetic acid 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 Show 18.75 Single 8JGB Conorfamide-Tx2 8JGB-MRGPRX1-Conorfamide-Tx2-Gi1/&β;1/&γ;2 Show 18.75 Consensus ffa3_on Orthosteric Ligand 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2 Show 18.75 Consensus gi_endothelin Orthosteric Ligand 8IY5-ETB -Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB -IRL1620-Gi1/&β;1/&γ;2 Show 18.75 Consensus smo_off_allo Orthosteric Ligand 6D32-SMO-Cyclopamine-Cyclopamine Show 18.52 Single 5WB2 CX3CL1.35 5WB2-US28-CX3CL1.35 Show 18.52 Single 6JOD Angiotensin II 6JOD-AT2 -Angiotensin II Show 18.52 Single 6MEO Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4 6MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4 Show 18.52 Single 6MET Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4 6MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4 Show 18.52 Consensus ste2_on Orthosteric Ligand 7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2 Show 18.18 Single 4AMI Bucindolol 4AMI-β1 -Bucindolol Show 18.18 Single 4LDE BI167107 4LDE-β2 -BI167107 Show 18.18 Single 5CXV Tiotropium 5CXV-M1 -Tiotropium Show 18.18 Single 5F8U Cyanopindolol 5F8U-β1 -Cyanopindolol Show 18.18 Single 6LRY Sarafotoxin-B 6LRY-ETB -Sarafotoxin-B Show 18.18 Single 6TKO Arformoterol 6TKO-β1 -Arformoterol-Arrestin2 Show 18.18 Single 6VMS Bromoergocryptine 6VMS-D2 -Bromoergocryptine-Gi1/&β;1/&γ;2 Show 18.18 Single 6XBL Cholesterol 6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2 Show 18.18 Single 7DH5 Mirabegron 7DH5-β3 -Mirabegron-Gs/&β;1/&γ;2 Show 18.18 Single 7JNI Olodanrigan 7JNI-AT2 -Olodanrigan Show 18.18 Single 7L1V PubChem 155491009 7L1V-OX2 -PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 Show 18.18 Single 7SUS PubChem 122701908 7SUS-Apelin-PubChem 122701908 Show 18.18 Single 7T6B S1P 7T6B-S1P2 -S1P-chim(NtGi1L-G13)/&β;1/&γ;2 Show 18.18 Single 7W0L PubChem 122701908 7W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2 Show 18.18 Single 7X1T Taltirelin 7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 Show 18.18 Single 7XW9 TRH 7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 Show 18.18 Single 7YIT Nalfurafine 7YIT-κ-Nalfurafine Show 18.18 Single 7YMJ Tamsulosin 7YMJ-Alpha1A-Tamsulosin Show 18.18 Single 8E9W 2-Deoxycytidine 8E9W-M3 -2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 Show 18.18 Single 8I95 EP54 8I95-C3aB -EP54-Go/&β;1/&γ;2 Show 18.18 Single 8IBU Erythromycin A 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 Show 18.18 Single 8JJ8 Formoterol 8JJ8-β2 -Formoterol Show 18.18 Single 8JJL Olodaterol 8JJL-β2 -Olodaterol Show 18.18 Single 8JWY PubChem 168451710 8JWY-A2A -PubChem 168451710 Show 18.18 Single 8U26 Protachykinin-1 8U26-NK1 -Protachykinin-1-Gs/&β;1/&γ;2 Show 18.18 Consensus at2_off Orthosteric Ligand 7JNI-AT2 -Olodanrigan Show 18.18 Consensus cannabinoid_off Orthosteric Ligand cb1_off cb2_off Show 18.18 Consensus gi_class-f Other Ligand gi_frizzled Show 18.18 Consensus gi_frizzled Other Ligand 6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2 Show 18.18 Consensus gs_trh Orthosteric Ligand 7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 Show 18.18 Consensus m1_off Orthosteric Ligand 5CXV-M1 -Tiotropium Show 18.18 Consensus mop_on Orthosteric Ligand 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2 Show 18.18 Consensus trh_on Orthosteric Ligand 7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 Show 17.95 Single 8GY7 Corticotropin 8GY7-MC2 -Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1 Show 17.86 Single 6UUN Adrenomedullin 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2 Show 17.86 Single 7F6H Bradykinin 7F6H-BK2 -Bradykinin-Gq/&β;1/&γ;2 Show 17.86 Single 7P02 Protachykinin-1 7P02-NK1 -Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2 Show 17.86 Single 7Y64 C5a anaphylatoxin 7Y64-C5a1 -C5a anaphylatoxin-Gi1/&β;1/&γ;2 Show 17.86 Single 8HCX Endothelin-1 8HCX-ETB -Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 Show 17.86 Single 8IOD PG-901 8IOD-MC5 -PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 Show 17.86 Consensus gs_melanocortin Orthosteric Ligand 7F4D-MC1 -Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC1 -Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC4 -Afamelanotide-Gs/&β;1/&γ;2 7F53-MC4 -Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4 -Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4 -Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC1 -SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC4 -THIQ-Gs/&β;1/&γ;2 Show 17.86 Consensus mc1_on Orthosteric Ligand 7F4H-MC1 -Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC1 -Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC1 -SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 Show 17.65 Single 3PBL Eticlopride 3PBL-D3 -Eticlopride Show 17.65 Single 5L7I Vismodegib 5L7I-SMO-Vismodegib Show 17.65 Single 6TP4 ACT-462206 6TP4-OX1 -ACT-462206 Show 17.65 Single 6TQ4 PubChem 16046844 6TQ4-OX1 -PubChem 16046844-Na Show 17.65 Single 7DD7 Ca; Ca; Tryptophan; Evocalcet 7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet Show 17.65 Single 7EJK Oxymetazoline 7EJK-α2a -Oxymetazoline-Go/&β;1/&γ;2 Show 17.65 Single 7TRP LY2033298 7TRP-M4 -Iperoxo-LY2033298-Gi1/&β;1/&γ;2 Show 17.65 Single 7VDH C48/80 7VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2 Show 17.65 Single 7XT9 Serotonin 7XT9-5-HT4 -Serotonin-Gs/&β;1/&γ;2 Show 17.65 Single 7XTB Serotonin 7XTB-5-HT6 -Serotonin-Gs/&β;1/&γ;2 Show 17.65 Single 8EF6 Morphine 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 Show 17.65 Single 8GEI Epinephrine 8GEI-β2 -Epinephrine-Gs/&β;1/&γ;2 Show 17.65 Single 8GGC Epinephrine 8GGC-β2 -Epinephrine-GTP-Gs/&β;1/&γ;2 Show 17.65 Single 8GGE Epinephrine 8GGE-β2 -Epinephrine-GTP-Gs/&β;1/&γ;2 Show 17.65 Single 8GGS Epinephrine 8GGS-β2 -Epinephrine Show 17.65 Single 8GGY Epinephrine 8GGY-β2 -Epinephrine Show 17.65 Single 8H8J Lodoxamide 8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2 Show 17.65 Single 8ITF DMCHA 8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2 Show 17.65 Single 8JLO Ulotaront 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 Show 17.65 Single 8UNV Epinephrine 8UNV-β2 -Epinephrine-GTP-Gs/&β;1/&γ;2 Show 17.65 Consensus d3_off Orthosteric Ligand 3PBL-D3 -Eticlopride Show 17.65 Consensus mt2_on Orthosteric Ligand 7VH0-MT2 -Ramelteon-Gi1/&β;1/&γ;1 Show 17.39 Single 5TUD Ergotamine 5TUD-5-HT2B -Ergotamine Show 17.39 Single 5UNG PubChem 15780052 5UNG-AT2 -PubChem 15780052 Show 17.39 Single 5UNH PubChem 126456406 5UNH-AT2 -PubChem 126456406 Show 17.39 Single 6BQH Ritanserin 6BQH-5-HT2C -Ritanserin Show 17.39 Single 6H7L Dobutamine 6H7L-β1 -Dobutamine Show 17.39 Single 6IBL Arformoterol 6IBL-β1 -Arformoterol Show 17.39 Single 7EZH Cholecystokinin-8 7EZH-CCKA -Cholecystokinin-8-Gi1/&β;1/&γ;2 Show 17.39 Single 7EZM Cholecystokinin-8 7EZM-CCKA -Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 Show 17.39 Single 7JVR Bromoergocryptine 7JVR-D2 -Bromoergocryptine-Gi1/&β;1/&γ;2 Show 17.39 Single 7MBY Cholecystokinin-8 7MBY-CCKA -Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 Show 17.39 Single 7P00 Substance P 7P00-NK1 -Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 Show 17.39 Single 7SK8 CCX662 7SK8-ACKR3-CXCL12-CCX662 Show 17.39 Single 7XJI Solabegron 7XJI-β3 -Solabegron-Gs/&β;1/&γ;2 Show 17.39 Consensus 5ht2c_off Orthosteric Ligand 6BQH-5-HT2C -Ritanserin Show 17.39 Consensus endothelin_off Orthosteric Ligand etb_off Show 17.39 Consensus etb_off Orthosteric Ligand 5XPR-ETB -Bosentan 6K1Q-ETB -IRL2500 5X93-ETB -K-8794 Show 17.39 Consensus gs_orexin Orthosteric Ligand 7L1U-OX2 -Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX2 -PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2 -TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 Show 17.39 Consensus nk2_on Orthosteric Ligand 7XWO-NK2 -Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 Show 17.39 Consensus orexin_on Orthosteric Ligand ox2_on Show 17.24 Single 7W3Z Gastrin Releasing Peptide 7W3Z-BB2 -Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2 Show 17.24 Single 7XV3 Lysophosphatidylserine 7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2 Show 16.67 Single 1GZM 11-cis-Retinal 1GZM-Rhodopsin-11-cis-Retinal Show 16.67 Single 2PED 9-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal Show 16.67 Single 3C9L 11-cis-Retinal 3C9L-Rhodopsin-11-cis-Retinal Show 16.67 Single 3PWH ZM241385 3PWH-A2A -ZM241385 Show 16.67 Single 4S0V Suvorexant 4S0V-OX2 -Suvorexant Show 16.67 Single 5K2D ZM241385 5K2D-A2A -ZM241385 Show 16.67 Single 6AKY Maraviroc 6AKY-CCR5-Maraviroc Show 16.67 Single 6B73 PubChem 131955138 6B73-κ-PubChem 131955138 Show 16.67 Single 6JZH ZM241385 6JZH-A2A -ZM241385-Na Show 16.67 Single 6KUX RS-79948 6KUX-α2a -RS-79948 Show 16.67 Single 6OBA (S)-Alprenolol 6OBA-β2 -(S)-Alprenolol-GTPL11074 Show 16.67 Single 6OMM WKYMVX 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2 Show 16.67 Single 6OYA All-trans-retinal 6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1 Show 16.67 Single 6PS7 ZM241385 6PS7-A2A -ZM241385-Na Show 16.67 Single 6TPJ Suvorexant 6TPJ-OX2 -Suvorexant Show 16.67 Single 6TQ6 PubChem 145714283 6TQ6-OX1 -PubChem 145714283 Show 16.67 Single 6XBJ Cholesterol 6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2 Show 16.67 Single 7DD7 Ca; Ca; Tryptophan; Evocalcet 7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet Show 16.67 Single 7DHR Isoprenaline 7DHR-β2 -Isoprenaline-Gs/&β;1/&γ;2 Show 16.67 Single 7EIB Des-Arg10-Kallidin 7EIB-BK1 -Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 Show 16.67 Single 7EJ0 L-Norepinephrine 7EJ0-α2a -L-Norepinephrine-Go/&β;1/&γ;2 Show 16.67 Single 7F24 Dopamine 7F24-D1 -Dopamine-GDP-Gs/&β;1/&γ;2 Show 16.67 Single 7F2O Bradykinin 7F2O-BK2 -Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 Show 16.67 Single 7F8Y Devazepide 7F8Y-CCKA -Devazepide Show 16.67 Single 7LJD Dopamine 7LJD-D1 -Dopamine-Mevidalen-Gs/&β;1/&γ;1 Show 16.67 Single 7M3F Ca; Ca; Tryptophan; Cinacalcet; PO4 7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4 Show 16.67 Single 7MTR ADX55164 7MTR-mGlu2; mGlu2-Glutamate-ADX55164 Show 16.67 Single 7RMG Substance P 7RMG-NK1 -Substance P-chim(Gs-CtGq)/&β;1/&γ;2 Show 16.67 Single 7SK9 CCX662 7SK9-ACKR3-CCX662 Show 16.67 Single 7SRS LSD 7SRS-5-HT2B -LSD-Arrestin2 Show 16.67 Single 7T94 PubChem 57664406 7T94-M2 -Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 Show 16.67 Single 7VDL Cortistatin-14 7VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2 Show 16.67 Single 7VIH CBP-307 7VIH-S1P1 -CBP-307-Gi1/&β;1/&γ;2 Show 16.67 Single 7VV5 C48/80 7VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2 Show 16.67 Single 7W0M PubChem 122701908 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2 Show 16.67 Single 7W0O Elabela 7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2 Show 16.67 Single 7W2Z Ghrelin 7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 Show 16.67 Single 7WF7 S1P 7WF7-S1P1 -S1P-Gi1/&β;1/&γ;2 Show 16.67 Single 7WVY Amyloid-Beta42 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 Show 16.67 Single 7X1U TRH 7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 Show 16.67 Single 7X5H 5-CT 7X5H-5-HT5A -5-CT-Gi1/&β;1/&γ;2 Show 16.67 Single 7XT8 Serotonin 7XT8-5-HT4 -Serotonin-Gs/&β;1/&γ;2 Show 16.67 Single 7YAE Octreotide 7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2 Show 16.67 Single 7YJ4 INSL5 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 Show 16.67 Single 7YM8 Oxymetazoline 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 Show 16.67 Single 7YMH Norepinephrine 7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 Show 16.67 Single 8DU3 PubChem 105526064 8DU3-A2A -PubChem 105526064 Show 16.67 Single 8F7R Endomorphin 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 Show 16.67 Single 8FN0 Neurotensin/neuromedin N 8FN0-NTS1 -Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2 Show 16.67 Single 8GEC Epinephrine 8GEC-β2 -Epinephrine-Gs/&β;1/&γ;2 Show 16.67 Single 8GED Epinephrine 8GED-β2 -Epinephrine-Gs/&β;1/&γ;2 Show 16.67 Single 8GEF Epinephrine 8GEF-β2 -Epinephrine-Gs/&β;1/&γ;2 Show 16.67 Single 8GG7 Epinephrine 8GG7-β2 -Epinephrine-GTP-Gs/&β;1/&γ;2 Show 16.67 Single 8GG9 Epinephrine 8GG9-β2 -Epinephrine-GTP-Gs/&β;1/&γ;2 Show 16.67 Single 8GGA Epinephrine 8GGA-β2 -Epinephrine-GTP-Gs/&β;1/&γ;2 Show 16.67 Single 8GGV Epinephrine 8GGV-β2 -Epinephrine Show 16.67 Single 8GGW Epinephrine 8GGW-β2 -Epinephrine Show 16.67 Single 8GGX Epinephrine 8GGX-β2 -Epinephrine Show 16.67 Single 8GH0 Epinephrine 8GH0-β2 -Epinephrine Show 16.67 Single 8GNG Istradefylline 8GNG-A2A -Istradefylline Show 16.67 Single 8HDP Adenosine 8HDP-A2B -Adenosine-Gs/&β;1/&γ;2 Show 16.67 Single 8IW4 Spermidine 8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2 Show 16.67 Single 8IWE Spermidine 8IWE-TAAR9-Spermidine Show 16.67 Single 8JBF Senktide 8JBF-NK3 -Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 Show 16.67 Single 8SZG Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW 8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2 Show 16.67 Single 8U8F PML 8U8F-GPR3-PML-Gs/&β;1/&γ;2 Show 16.67 Single 8UNL Epinephrine 8UNL-β2 -Epinephrine-GTP-Gs/&β;1/&γ;2 Show 16.67 Single 8UNO Epinephrine 8UNO-β2 -Epinephrine-GTP-Gs/&β;1/&γ;2 Show 16.67 Single 8UNT Epinephrine 8UNT-β2 -Epinephrine-GTP-Gs/&β;1/&γ;2 Show 16.67 Single 8UNU Epinephrine 8UNU-β2 -Epinephrine-GTP-Gs/&β;1/&γ;2 Show 16.67 Single 8UNW Epinephrine 8UNW-β2 -Epinephrine-GTP-Gs/&β;1/&γ;2 Show 16.67 Single 8UO3 Epinephrine 8UO3-β2 -Epinephrine-GTP; Mg-Gs/&β;1/&γ;2 Show 16.67 Single 8WPG Tryptophan; Cinacalcet; PO4; Ca 8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca Show 16.67 Single 8X5Y Astemizole 8X5Y-H1 -Astemizole Show 16.67 Consensus 5ht2c_on Orthosteric Ligand 8DPF-5-HT2C -Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C -Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 Show 16.67 Consensus 5ht_on Orthosteric Ligand 5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on Show 16.67 Consensus a2a_off_allo Orthosteric Ligand 6ZDR-A2A -HMS1413f12-Na 6GT3-A2A -Imaradenant-Na 8CU7-A2A -LJ-4517-Na 5OLV-A2A -LUAA41063-Na 5N2R-A2A -PubChem 92460631; psb36-Na 5MZJ-A2A -Theophylline-Na 5OLO-A2A -Tozadenant-Na 5OLH-A2A -Vipadenant-Na 5NM4-A2A -ZM241385-Na 8GNE-A2A -KW-6356-Na 8JWZ-A2A -AB928-Na 5MZP-A2A -Caffeine-Na 8CIC-A2A -Etrumadenant-Na Show 16.67 Consensus alpha1_on Orthosteric Ligand alpha1a_on Show 16.67 Consensus alpha1a_on Orthosteric Ligand 7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 Show 16.67 Consensus alpha2_off Orthosteric Ligand alpha2a_off alpha2c_off Show 16.67 Consensus alpha2a_off Orthosteric Ligand 6KUX-α2a -RS-79948 Show 16.67 Consensus beta2_off_allo Orthosteric Ligand 6OBA-β2 -(S)-Alprenolol-GTPL11074 Show 16.67 Consensus ccr8_on Orthosteric Ligand 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2 Show 16.67 Consensus class-d_off Orthosteric Ligand ste2_off Show 16.67 Consensus cxcr1_on Orthosteric Ligand 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 Show 16.67 Consensus etb_on Orthosteric Ligand 8HCX-ETB -Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB -IRL1620-Gi1/&β;1/&γ;2 Show 16.67 Consensus fpr2-alx_on Orthosteric Ligand 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2 Show 16.67 Consensus gi_apelin Orthosteric Ligand 7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2 Show 16.67 Consensus go_ghrelin Orthosteric Ligand 7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 Show 16.67 Consensus gs_5ht Orthosteric Ligand 7XT8-5-HT4 -Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT6 -Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6 -ST1936-Gs/&β;1/&γ;2 7XTC-5-HT7 -5-CT-Gs/&β;1/&γ;2 6WHA-5-HT2A -DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT2A -PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT2C -Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C -Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 Show 16.67 Consensus gs_cgrp Orthosteric Ligand 6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2 Show 16.67 Consensus gt_class-a Orthosteric Ligand gt_opsin Show 16.67 Consensus gt_opsin Orthosteric Ligand gt_sensory Show 16.67 Consensus gt_sensory Orthosteric Ligand 6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1 Show 16.67 Consensus lipid_on Orthosteric Ligand cannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on Show 16.67 Consensus m2_on_allo Other Ligand 7T94-M2 -Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2 -Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2 Show 16.67 Consensus mc4_on Orthosteric Ligand 7F53-MC4 -Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4 -Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4 -Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4 -THIQ-Gs/&β;1/&γ;2 7F54-MC4 -Afamelanotide-Gs/&β;1/&γ;2 Show 16.67 Consensus mglu_on Other Ligand mglu2_on mglu4_on Show 16.67 Consensus motilin_on Orthosteric Ligand 8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 Show 16.67 Consensus nk1_on Orthosteric Ligand 8U26-NK1 -Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1 -Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 Show 16.67 Consensus ste2_on Orthosteric Ligand 7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2 Show 16.13 Single 8FEG PRD_002517 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 Show 16.13 Single 8IY6 Endothelin-1 8IY6-ETB -Endothelin-1 Show 16.13 Consensus gi_chemokine Orthosteric Ligand 7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2 Show 16.13 Consensus gq_bradykinin Orthosteric Ligand 7F6H-BK2 -Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2 -Kallidin-Gq/&β;1/&γ;2 Show 16.00 Single 5VBL Apelin Mimetic Peptide Agonist 5VBL-Apelin-Apelin Mimetic Peptide Agonist Show 16.00 Single 7F54 Afamelanotide 7F54-MC4 -Afamelanotide-Gs/&β;1/&γ;2 Show 16.00 Single 7QA8 Peptide 7QA8-STE2-Peptide Show 16.00 Single 7QA8 Peptide 7QA8-STE2-Peptide Show 16.00 Single 7RMH Substance P 7RMH-NK1 -Substance P-Gs/&β;1/&γ;2 Show 16.00 Single 7XMR Somatostatin-14 7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 Show 16.00 Single 8DCR Dobutamine 8DCR-β1 -Dobutamine-Gs/&β;1/&γ;2 Show 16.00 Single 8JZZ C5a-desArg 8JZZ-C5a1 -C5a-desArg-Go/&β;1/&γ;2 Show 16.00 Consensus class-d_off Orthosteric Ligand ste2_off Show 16.00 Consensus gi_relaxin Orthosteric Ligand 7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2 Show 16.00 Consensus nmur1_on Orthosteric Ligand 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 Show 15.79 Single 2YDO Adenosine 2YDO-A2A -Adenosine Show 15.79 Single 3OAX 11-cis-Retinal 3OAX-Rhodopsin-11-cis-Retinal Show 15.79 Single 3RZE Cidoxepin 3RZE-H1 -Cidoxepin Show 15.79 Single 4DKL Beta-funaltrexamine 4DKL-μ-Beta-funaltrexamine Show 15.79 Single 4MQT Iperoxo 4MQT-M2 -Iperoxo-LY2119620 Show 15.79 Single 5IU4 ZM241385 5IU4-A2A -ZM241385-Na Show 15.79 Single 5IU7 Q27456346 5IU7-A2A -Q27456346-Na Show 15.79 Single 5IUB Q27456344 5IUB-A2A -Q27456344-Na Show 15.79 Single 5JTB ZM241385 5JTB-A2A -ZM241385 Show 15.79 Single 5K2B ZM241385 5K2B-A2A -ZM241385-Na Show 15.79 Single 5K2C ZM241385 5K2C-A2A -ZM241385-Na Show 15.79 Single 5NLX ZM241385 5NLX-A2A -ZM241385-Na Show 15.79 Single 5NM4 ZM241385 5NM4-A2A -ZM241385-Na Show 15.79 Single 6AQF ZM241385 6AQF-A2A -ZM241385 Show 15.79 Single 6K41 Dexmedetomidine 6K41-α2b -Dexmedetomidine-Go/&β;1/&γ;2 Show 15.79 Single 6MH8 ZM241385 6MH8-A2A -ZM241385 Show 15.79 Single 6TP3 Nemorexant 6TP3-OX1 -Nemorexant Show 15.79 Single 6TPG EMPA 6TPG-OX2 -EMPA Show 15.79 Single 6V9S GTPL11403 6V9S-OX1 -GTPL11403 Show 15.79 Single 6WJC Atropine 6WJC-M1 -Atropine-Muscarinic toxin 7 Show 15.79 Single 6ZDR HMS1413f12 6ZDR-A2A -HMS1413f12-Na Show 15.79 Single 7ARO LUF5833 7ARO-A2A -LUF5833-Na Show 15.79 Single 7CMV PD128907 7CMV-D3 -PD128907-Gi1/&β;1/&γ;2 Show 15.79 Single 7DHI Salbutamol 7DHI-β2 -Salbutamol-Gs/&β;1/&γ;2 Show 15.79 Single 7E33 BRL-54443 7E33-5-HT1E -BRL-54443-Gi1/&β;1/&γ;2 Show 15.79 Single 7EJ8 Brimonidine 7EJ8-α2a -Brimonidine-Go/&β;1/&γ;2 Show 15.79 Single 7EJA Dexmedetomidine 7EJA-α2a -Dexmedetomidine-Go/&β;1/&γ;2 Show 15.79 Single 7F61 PF-03654746 7F61-H3 -PF-03654746-Cholesterol Show 15.79 Single 7T32 ZM241385 7T32-A2A -ZM241385 Show 15.79 Single 7VUG JNJ-63533054 7VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2 Show 15.79 Single 7VV6 C48/80 7VV6-MRGPRX2-C48/80 Show 15.79 Single 7ZBC 11-cis-Retinal 7ZBC-Rhodopsin-11-cis-Retinal Show 15.79 Single 7ZBE 11-cis-Retinal 7ZBE-Rhodopsin-11-cis-Retinal Show 15.79 Single 8FCZ 11-cis-Retinal 8FCZ-Rhodopsin-11-cis-Retinal Show 15.79 Single 8GDZ Epinephrine 8GDZ-β2 -Epinephrine-Gs/&β;1/&γ;2 Show 15.79 Single 8GE1 Epinephrine 8GE1-β2 -Epinephrine-Gs/&β;1/&γ;2 Show 15.79 Single 8GE4 Epinephrine 8GE4-β2 -Epinephrine-Gs/&β;1/&γ;2 Show 15.79 Single 8GE6 Epinephrine 8GE6-β2 -Epinephrine-Gs/&β;1/&γ;2 Show 15.79 Single 8GE7 Epinephrine 8GE7-β2 -Epinephrine-Gs/&β;1/&γ;2 Show 15.79 Single 8GE8 Epinephrine 8GE8-β2 -Epinephrine-Gs/&β;1/&γ;2 Show 15.79 Single 8GE9 Epinephrine 8GE9-β2 -Epinephrine-Gs/&β;1/&γ;2 Show 15.79 Single 8GFV Epinephrine 8GFV-β2 -Epinephrine-GTP-Gs/&β;1/&γ;2 Show 15.79 Single 8GG3 Epinephrine 8GG3-β2 -Epinephrine-GTP-Gs/&β;1/&γ;2 Show 15.79 Single 8GG4 Epinephrine 8GG4-β2 -Epinephrine-GTP-Gs/&β;1/&γ;2 Show 15.79 Single 8GGI Epinephrine 8GGI-β2 -Epinephrine Show 15.79 Single 8GGL Epinephrine 8GGL-β2 -Epinephrine Show 15.79 Single 8GGT Epinephrine 8GGT-β2 -Epinephrine Show 15.79 Single 8H4L Doconexent 8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 Show 15.79 Single 8HJ5 PubChem 139030531 8HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 Show 15.79 Single 8IYX YL-365 8IYX-GPR34-YL-365 Show 15.79 Single 8JLK Ulotaront 8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2 Show 15.79 Single 8JLQ Fenoldopam 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 Show 15.79 Single 8JSP Ulotaront 8JSP-5-HT1A -Ulotaront-Gi1/&β;1/&γ;2 Show 15.79 Single 8T3V DHA 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 Show 15.79 Single 8THK A61603 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 Show 15.79 Single 8UNQ Epinephrine 8UNQ-β2 -Epinephrine-GTP-Gs/&β;1/&γ;2 Show 15.79 Single 8UNR Epinephrine 8UNR-β2 -Epinephrine-GTP-Gs/&β;1/&γ;2 Show 15.79 Single 8UNS Epinephrine 8UNS-β2 -Epinephrine-GTP-Gs/&β;1/&γ;2 Show 15.79 Single 8W88 SEP-363856 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 Show 15.79 Single 8WC8 ZH8651 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2 Show 15.79 Consensus 5ht1e_on Orthosteric Ligand 7E33-5-HT1E -BRL-54443-Gi1/&β;1/&γ;2 Show 15.79 Consensus alpha2b_on Orthosteric Ligand 6K41-α2b -Dexmedetomidine-Go/&β;1/&γ;2 Show 15.79 Consensus at1_off Orthosteric Ligand 4YAY-AT1 -ZD-7155 4ZUD-AT1 -Olmesartan Show 15.79 Consensus cxcr_on Orthosteric Ligand cxcr1_on cxcr2_on Show 15.79 Consensus h3_on_allo Orthosteric Ligand 7F61-H3 -PF-03654746-Cholesterol Show 15.79 Consensus lh_on_allo Other Ligand 7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2 Show 15.79 Consensus m1_off_allo Orthosteric Ligand 6WJC-M1 -Atropine-Muscarinic toxin 7 Show 15.79 Consensus sensory_off Orthosteric Ligand opsin_off Show 15.62 Single 6IGK Endothelin-3 6IGK-ETB -Endothelin-3 Show 15.62 Single 6PB0 Urocortin 6PB0-CRF1 -Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2 Show 15.62 Single 7TS0 Urocortin 7TS0-CRF2 -Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2 Show 15.62 Consensus bb2_on Orthosteric Ligand 7W40-BB2 -Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2 -Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2 Show 15.62 Consensus gq_bombesin Orthosteric Ligand 7W40-BB2 -Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2 -Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2 Show 15.38 Single 5XJM (Sar1,Ile8)-Angiotensin II 5XJM-AT2 -(Sar1,Ile8)-Angiotensin II Show 15.38 Single 6DO1 Angiotensin-Like peptide S1I8 6DO1-AT1 -Angiotensin-Like peptide S1I8 Show 15.38 Single 7C6A (Sar1,Ile8)-Angiotensin II 7C6A-AT2 -(Sar1,Ile8)-Angiotensin II Show 15.38 Single 7EZK Cholecystokinin-8 7EZK-CCKA -Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2 Show 15.38 Single 7PIV Setmelanotide 7PIV-MC4 -Setmelanotide-Gs/&β;1/&γ;2 Show 15.38 Single 7RMI Substance P 7RMI-NK1 -Substance P-chim(Gs-CtGq)/&β;1/&γ;2 Show 15.38 Single 7W56 Neuromedin-S 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 Show 15.38 Single 8DWG Proenkephalin-A 8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 Show 15.38 Consensus alpha1_off Orthosteric Ligand alpha1a_off alpha1b_off Show 15.15 Single 7SK6 CXCL12_LRHQ 7SK6-ACKR3-CXCL12_LRHQ Show 15.15 Single 8HBD IRL1620 8HBD-ETB -IRL1620-Gi1/&β;1/&γ;2 Show 15.00 Single 1HZX 11-cis-Retinal 1HZX-Rhodopsin-11-cis-Retinal Show 15.00 Single 2Y01 Dobutamine 2Y01-β1 -Dobutamine Show 15.00 Single 2Y04 Salbutamol 2Y04-β1 -Salbutamol Show 15.00 Single 3EML ZM241385 3EML-A2A -ZM241385 Show 15.00 Single 3NYA (S)-Alprenolol 3NYA-β2 -(S)-Alprenolol Show 15.00 Single 4EA3 PubChem 10296561 4EA3-NOP-PubChem 10296561 Show 15.00 Single 4EIY ZM241385 4EIY-A2A -ZM241385-Na Show 15.00 Single 4MQS Iperoxo 4MQS-M2 -Iperoxo Show 15.00 Single 4QKX PubChem 76210628 4QKX-β2 -PubChem 76210628 Show 15.00 Single 4U14 Tiotropium 4U14-M3 -Tiotropium Show 15.00 Single 4YAY ZD-7155 4YAY-AT1 -ZD-7155 Show 15.00 Single 4ZUD Olmesartan 4ZUD-AT1 -Olmesartan Show 15.00 Single 5IU8 Q27456347 5IU8-A2A -Q27456347-Na Show 15.00 Single 5K2A ZM241385 5K2A-A2A -ZM241385-Na Show 15.00 Single 5OLG ZM241385 5OLG-A2A -ZM241385-Na Show 15.00 Single 5OLZ PubChem 135566609 5OLZ-A2A -PubChem 135566609-Na Show 15.00 Single 5OM1 PubChem 135566609 5OM1-A2A -PubChem 135566609-Na Show 15.00 Single 5UEN DU172 5UEN-A1 -DU172 Show 15.00 Single 5UIG J3.651.884G 5UIG-A2A -J3.651.884G Show 15.00 Single 5VRA ZM241385 5VRA-A2A -ZM241385-Na Show 15.00 Single 6FKD PubChem 137349183 6FKD-Rhodopsin-PubChem 137349183 Show 15.00 Single 6H7M Salbutamol 6H7M-β1 -Salbutamol Show 15.00 Single 6LPJ ZM241385 6LPJ-A2A -ZM241385-Na Show 15.00 Single 6LPK ZM241385 6LPK-A2A -ZM241385-Na Show 15.00 Single 6PS1 Timolol 6PS1-β2 -Timolol Show 15.00 Single 6S0L ZM241385 6S0L-A2A -ZM241385 Show 15.00 Single 6TOT Lemborexant 6TOT-OX1 -Lemborexant Show 15.00 Single 6Z4V NTS8-13 6Z4V-NTS1 -NTS8-13 Show 15.00 Single 7CFM P395 7CFM-GPBA-P395-Gs/&β;1/&γ;2 Show 15.00 Single 7E32 Serotonin 7E32-5-HT1D -Serotonin-Gi1/&β;1/&γ;2 Show 15.00 Single 7E9G JNJ-40411813 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2 Show 15.00 Single 7FIH Org43553 7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2 Show 15.00 Single 7PYR PSB-2115 7PYR-A2A -PSB-2115 Show 15.00 Single 7SCG FH210 7SCG-μ-FH210-Gi1/&β;1/&γ;2 Show 15.00 Single 7T2G Mitragynine pseudoindoxyl 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 Show 15.00 Single 7TRP Iperoxo 7TRP-M4 -Iperoxo-LY2033298-Gi1/&β;1/&γ;2 Show 15.00 Single 7UL4 Alvimopan 7UL4-μ-Alvimopan Show 15.00 Single 7VIE S1P 7VIE-S1P1 -S1P-Gi1/&β;1/&γ;2 Show 15.00 Single 7VIF (S)-FTY720-P 7VIF-S1P1 -(S)-FTY720-P-Gi1/&β;1/&γ;2 Show 15.00 Single 7WC7 Lisuride 7WC7-5-HT2A -Lisuride Show 15.00 Single 7XJH Isoproterenol 7XJH-β3 -Isoproterenol-Gs/&β;1/&γ;2 Show 15.00 Single 7XTC 5-CT 7XTC-5-HT7 -5-CT-Gs/&β;1/&γ;2 Show 15.00 Single 8CIC Etrumadenant 8CIC-A2A -Etrumadenant-Na Show 15.00 Single 8CU6 LJ-4517 8CU6-A2A -LJ-4517 Show 15.00 Single 8CU7 LJ-4517 8CU7-A2A -LJ-4517-Na Show 15.00 Single 8DZS GR89,696 8DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2 Show 15.00 Single 8EFQ Damgo 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 Show 15.00 Single 8EJC TAK-875 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 Show 15.00 Single 8GEB Epinephrine 8GEB-β2 -Epinephrine-Gs/&β;1/&γ;2 Show 15.00 Single 8IC0 Interleukin-8 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 Show 15.00 Single 8J18 (3R)-3-hydroxydodecanoic acid 8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2 Show 15.00 Single 8JGG BAM8-22 8JGG-MRGPRX1-BAM8-22-Gi1/&β;1/&γ;2 Show 15.00 Single 8JJO Alprenolol 8JJO-β2 -Alprenolol Show 15.00 Single 8KFY ZK-756326 8KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2 Show 15.00 Single 8UNM Epinephrine 8UNM-β2 -Epinephrine-GTP-Gs/&β;1/&γ;2 Show 15.00 Single 8UO4 Epinephrine 8UO4-β2 -Epinephrine-GTP; Mg-Gs/&β;1/&γ;2 Show 15.00 Single 8W8A RO5256390 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 Show 15.00 Single 8X63 Mepyramine 8X63-H1 -Mepyramine Show 15.00 Single 8X64 Desloratadine 8X64-H1 -Desloratadine Show 15.00 Consensus 5ht1a_on Orthosteric Ligand 8JSP-5-HT1A -Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT1A -Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A -SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT1A -Serotonin-Gi1/&β;1/&γ;2 Show 15.00 Consensus 5ht1d_on Orthosteric Ligand 7E32-5-HT1D -Serotonin-Gi1/&β;1/&γ;2 Show 15.00 Consensus 5ht2_off Orthosteric Ligand 5ht2a_off 5ht2b_off 5ht2c_off Show 15.00 Consensus 5ht7_on Orthosteric Ligand 7XTC-5-HT7 -5-CT-Gs/&β;1/&γ;2 Show 15.00 Consensus a2_off Orthosteric Ligand a2a_off Show 15.00 Consensus a2a_off Orthosteric Ligand 8C9W-A2A -Etrumadenant 3UZA-A2A -GTPL9236 8GNG-A2A -Istradefylline 5UIG-A2A -J3.651.884G 8CU6-A2A -LJ-4517 7PX4-A2A -PSB-2113 7PYR-A2A -PSB-2115 8DU3-A2A -PubChem 105526064 8JWY-A2A -PubChem 168451710 5K2D-A2A -ZM241385 Show 15.00 Consensus adenosine_on Orthosteric Ligand a1_on a2_on Show 15.00 Consensus alpha_off Orthosteric Ligand alpha1_off alpha2_off Show 15.00 Consensus amine_on Orthosteric Ligand adrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on Show 15.00 Consensus cb1_on_allo Orthosteric Ligand 7WV9-CB1 -PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2 Show 15.00 Consensus cck_off Orthosteric Ligand ccka_off Show 15.00 Consensus ccka_off Orthosteric Ligand 7F8Y-CCKA -Devazepide 7F8U-CCKA -Lintitript Show 15.00 Consensus d5_on Orthosteric Ligand 8IRV-D5 -Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 Show 15.00 Consensus ffa1_on Orthosteric Ligand 8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 Show 15.00 Consensus gi_hca Orthosteric Ligand 8H2G-HCA2 -Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA3 -Acifran-Gi1/&β;1/&γ;2 8IHI-HCA2 -Acifran-Gi1/&β;1/&γ;2 8IHB-HCA2 -GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA2 -LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2 -MK6892-Gi1/&β;1/&γ;2 8JIM-HCA2 -MMF-Gi1/&β;1/&γ;2 8IJB-HCA2 -Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2 -MK6892-Gi1/&β;1/&γ;2 Show 15.00 Consensus gi_hcar Orthosteric Ligand gi_hca Show 15.00 Consensus gq_amine Orthosteric Ligand gq_muscarinic gq_histamine Show 15.00 Consensus hca2_on Orthosteric Ligand 8H2G-HCA2 -Niacin-Gi1/&β;1/&γ;2 8IHI-HCA2 -Acifran-Gi1/&β;1/&γ;2 8IHH-HCA2 -LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2 -MK6892-Gi1/&β;1/&γ;2 8JHY-HCA2 -Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA2 -GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA2 -MMF-Gi1/&β;1/&γ;2 8IJB-HCA2 -Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2 -MK6892-Gi1/&β;1/&γ;2 8J6J-HCA2 -GSK256073-Gi1/&β;1/&γ;2 Show 15.00 Consensus m2_on_allo Orthosteric Ligand 7T94-M2 -Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2 -Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2 Show 15.00 Consensus m4_on_allo Orthosteric Ligand 7TRP-M4 -Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4 -Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4 -Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2 Show 15.00 Consensus muscarinic_on Orthosteric Ligand m2_on m3_on m4_on m1_on Show 15.00 Consensus nucleotide_on Orthosteric Ligand adenosine_on Show 15.00 Consensus smo_off Orthosteric Ligand 5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680) Show 15.00 Consensus tachykinin_off Orthosteric Ligand nk1_off Show 14.81 Single 7F4H Afamelanotide 7F4H-MC1 -Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 Show 14.81 Single 8XZH MM07 8XZH-Apelin-MM07-Gi1/&β;1/&γ;2 Show 14.81 Consensus go_peptide Orthosteric Ligand go_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin Show 14.81 Consensus gs_motilin Orthosteric Ligand 8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 Show 14.81 Consensus gs_tachykinin Orthosteric Ligand 8U26-NK1 -Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2 -Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1 -Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 Show 14.81 Consensus mc3_on Orthosteric Ligand 8IOC-MC3 -Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 Show 14.81 Consensus tachykinin_on Orthosteric Ligand nk1_on nk2_on Show 14.71 Single 8U1U CCL1 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2 Show 14.29 Single 2Y00 Dobutamine 2Y00-β1 -Dobutamine Show 14.29 Single 2Y03 Isoprenaline 2Y03-β1 -Isoprenaline Show 14.29 Single 5IUA Q27456348 5IUA-A2A -Q27456348-Na Show 14.29 Single 5MZP Caffeine 5MZP-A2A -Caffeine-Na Show 14.29 Single 5OM4 PubChem 135566609 5OM4-A2A -PubChem 135566609-Na Show 14.29 Single 5ZK3 Quinuclidinyl benzilate hydrobromide 5ZK3-M2 -Quinuclidinyl benzilate hydrobromide Show 14.29 Single 6D26 Fevipiprant 6D26-DP2 -Fevipiprant Show 14.29 Single 6GDG NECA 6GDG-A2A -NECA-Gs/&β;1/&γ;1 Show 14.29 Single 6LPL ZM241385 6LPL-A2A -ZM241385-Na Show 14.29 Single 6N4B MDMB-Fubinaca 6N4B-CB1 -MDMB-Fubinaca-Gi1/&β;1/&γ;2 Show 14.29 Single 6OIK Iperoxo 6OIK-M2 -Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2 Show 14.29 Single 6S0Q ZM241385 6S0Q-A2A -ZM241385 Show 14.29 Single 6WI9 Secretin 6WI9-Secretin-Secretin-Gs/&β;1/&γ;2 Show 14.29 Single 6WQA ZM241385 6WQA-A2A -ZM241385-Na Show 14.29 Single 6Z8N SRI-9829 6Z8N-NTS1 -SRI-9829 Show 14.29 Single 7BZ2 Arformoterol 7BZ2-β2 -Arformoterol-Gs/&β;1/&γ;2 Show 14.29 Single 7DW9 Acyclovir triphosphate 7DW9-V2 -Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2 Show 14.29 Single 7EO2 FTY720-P 7EO2-S1P1 -FTY720-P-Gi1/&β;1/&γ;2 Show 14.29 Single 7RM5 ZM241385 7RM5-A2A -ZM241385-Na Show 14.29 Single 7T9N PubChem 644078 7T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2 Show 14.29 Single 7TRK Iperoxo 7TRK-M4 -Iperoxo-Gi1/&β;1/&γ;2 Show 14.29 Single 7VV0 PAMP-12 7VV0-MRGPRX2-PAMP-12 Show 14.29 Single 7W40 Bombesin 7W40-BB2 -Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 Show 14.29 Single 7WIG L-054,264 7WIG-SST2-L-054,264-Gi1/&β;1/&γ;2 Show 14.29 Single 8C9W Etrumadenant 8C9W-A2A -Etrumadenant Show 14.29 Single 8FN1 Neurotensin/neuromedin N 8FN1-NTS1 -Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2 Show 14.29 Single 8FYN ZM241385 8FYN-A2A -ZM241385-Na Show 14.29 Single 8J19 PubChem 127045422 8J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2 Show 14.29 Single 8J6J GSK256073 8J6J-HCA2 -GSK256073-Gi1/&β;1/&γ;2 Show 14.29 Single 8KFX LMD-009 8KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2 Show 14.29 Single 8WCC Cyclohexylammonium ion 8WCC-TA1-Cyclohexylammonium ion Show 14.29 Single 8WPU Tryptophan; Cinacalcet; PO4; Ca 8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 Show 14.29 Single 9AXF Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4 9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 Show 14.29 Consensus a2a_on Orthosteric Ligand 6GDG-A2A -NECA-Gs/&β;1/&γ;1 Show 14.29 Consensus beta_on Orthosteric Ligand beta1_on beta2_on beta3_on Show 14.29 Consensus bk2_on Orthosteric Ligand 7F2O-BK2 -Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2 -Kallidin-Gq/&β;1/&γ;2 Show 14.29 Consensus d2_on Orthosteric Ligand 7JVR-D2 -Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2 -Rotigotine-Gi1/&β;1/&γ;2 Show 14.29 Consensus gq_muscarinic Orthosteric Ligand 6OIJ-M1 -Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2 Show 14.29 Consensus gs_muscarinic Orthosteric Ligand 8E9W-M3 -2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M3 -Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 Show 14.29 Consensus m1_on Orthosteric Ligand 6OIJ-M1 -Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2 Show 14.29 Consensus m3_on Orthosteric Ligand 8E9Z-M3 -Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M3 -2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 Show 14.29 Consensus pth2_on Orthosteric Ligand 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 Show 14.29 Consensus v2_on Orthosteric Ligand 7DW9-V2 -Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2 Show 13.79 Single 7F6I Kallidin 7F6I-BK2 -Kallidin-Gq/&β;1/&γ;2 Show 13.79 Single 7WBJ PACAP27 7WBJ-VPAC1 -PACAP27-Gs/&β;1/&γ;2 Show 13.79 Consensus bk1_on Orthosteric Ligand 7EIB-BK1 -Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 Show 13.79 Consensus bombesin_on Orthosteric Ligand bb2_on bb1_on Show 13.79 Consensus c5a1_on Orthosteric Ligand 7Y65-C5a1 -C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1 -Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1 -BM213-Gi1/&β;1/&γ;2 7Y67-C5a1 -C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1 -C5a anaphylatoxin-Gi1/&β;1/&γ;2 Show 13.79 Consensus gs_bradykinin Orthosteric Ligand 7F2O-BK2 -Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK1 -Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 Show 13.64 Single 3UON Quinuclidinyl benzilate hydrobromide 3UON-M2 -Quinuclidinyl benzilate hydrobromide Show 13.64 Single 3ZEV Neurotensin 3ZEV-NTS1 -Neurotensin Show 13.64 Single 4BV0 Neurotensin 4BV0-NTS1 -Neurotensin Show 13.64 Single 4LDL Hydroxybenzylisoproterenol 4LDL-β2 -Hydroxybenzylisoproterenol Show 13.64 Single 5V54 Methiothepin 5V54-5-HT1B -Methiothepin Show 13.64 Single 5V56 TC114 5V56-SMO-TC114 Show 13.64 Single 5ZBH BMS-193885 5ZBH-Y1 -BMS-193885 Show 13.64 Single 5ZKB AF-DX 384 5ZKB-M2 -AF-DX 384 Show 13.64 Single 6E59 L-760735 6E59-NK1 -L-760735 Show 13.64 Single 6J20 Aprepitant 6J20-NK1 -Aprepitant Show 13.64 Single 6O3C Cholesterol 6O3C-SMO-SAG21k-Cholesterol Show 13.64 Single 6OIJ Iperoxo 6OIJ-M1 -Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2 Show 13.64 Single 6OS1 TRV026 6OS1-AT1 -TRV026 Show 13.64 Single 6UP7 Neurotensin 6UP7-NTS1 -Neurotensin-Arrestin2 Show 13.64 Single 6W2X PubChem 23727970 6W2X-GABAB1 , GABAB2 -PubChem 5311042-PubChem 23727970 Show 13.64 Single 7B6W Cyclazosin 7B6W-α1b -Cyclazosin Show 13.64 Single 7E2Z Aripiprazole 7E2Z-5-HT1A -Aripiprazole-Gi1/&β;1/&γ;2 Show 13.64 Single 7EPE NAM563 7EPE-mGlu-NAM563 Show 13.64 Single 7F58 THIQ 7F58-MC4 -THIQ-Gs/&β;1/&γ;2 Show 13.64 Single 7L0P Neurotensin 7L0P-NTS1 -Neurotensin-Gi1/&β;1/&γ;1 Show 13.64 Single 7L0Q Neurotensin 7L0Q-NTS1 -Neurotensin-Gi1/&β;1/&γ;1 Show 13.64 Single 7PX4 PSB-2113 7PX4-A2A -PSB-2113 Show 13.64 Single 7TRQ Iperoxo 7TRQ-M4 -Iperoxo-VU0467154-Gi1/&β;1/&γ;2 Show 13.64 Single 7U2L PubChem 163201242 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 Show 13.64 Single 7XWO Neurokinin-A 7XWO-NK2 -Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 Show 13.64 Single 7Y67 C089 peptide 7Y67-C5a1 -C089 peptide-Gi1/&β;1/&γ;2 Show 13.64 Single 8DZP momSalB 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 Show 13.64 Single 8EF5 Fentanyl 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 Show 13.64 Single 8FMZ Neurotensin/neuromedin N 8FMZ-NTS1 -Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 Show 13.64 Single 8G05 6-OAU 8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2 Show 13.64 Single 8JD0 J9R 8JD0-mGlu2; mGlu3-Glutamate-J9R Show 13.64 Single 8SZH Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW 8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2 Show 13.64 Single 9AYF Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4 9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2 Show 13.64 Consensus 5ht1_off Orthosteric Ligand 5ht1b_off Show 13.64 Consensus 5ht1b_off Orthosteric Ligand 5V54-5-HT1B -Methiothepin Show 13.64 Consensus adenosine_off Orthosteric Ligand a1_off a2_off Show 13.64 Consensus alpha1b_off Orthosteric Ligand 7B6W-α1b -Cyclazosin Show 13.64 Consensus chemerin_on Orthosteric Ligand cml1_on Show 13.64 Consensus cml1_on Orthosteric Ligand 8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2 Show 13.64 Consensus gi_muscarinic Orthosteric Ligand 7TRS-M4 -Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4 -Iperoxo-Gi1/&β;1/&γ;2 7V6A-M4 -PubChem 9864275-Gi1/&β;1/&γ;2 Show 13.64 Consensus mglu2_on Other Ligand 7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2 Show 13.64 Consensus muscarinic_off Orthosteric Ligand m2_off m3_off m4_off m5_off m1_off Show 13.64 Consensus nts1_on_allo Orthosteric Ligand 8JPB-NTS1 -Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2 Show 13.64 Consensus sst4_on Orthosteric Ligand 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 Show 13.33 Single 7QBI Alpha-factor mating pheromone 7QBI-STE2-Alpha-factor mating pheromone Show 13.33 Single 7RGP Tirzepatide 7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 Show 13.33 Single 7SK3 CXCL12 7SK3-ACKR3-CXCL12 Show 13.33 Single 7VAB Non-Acylated Tirzepatide 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 Show 13.33 Single 7XKE Betahydroxyandrosterone 7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2 Show 13.33 Single 8GEJ Epinephrine 8GEJ-β2 -Epinephrine-Gs/&β;1/&γ;2 Show 13.33 Single 8H0P NMB30 8H0P-BB1 -NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 Show 13.33 Consensus bb1_on Orthosteric Ligand 8H0P-BB1 -NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 Show 13.33 Consensus bradykinin_on Orthosteric Ligand bk2_on bk1_on Show 13.33 Consensus ccr5_on Orthosteric Ligand 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 Show 13.33 Consensus class-d_on Orthosteric Ligand ste2_on Show 13.33 Consensus gi_compl-peptide Orthosteric Ligand 8HK5-C5a1 -Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB -E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1 -BM213-Gi1/&β;1/&γ;2 7Y67-C5a1 -C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB -C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1 -C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1 -C5a peptide-Gi1/&β;1/&γ;2 Show 13.04 Single 4GRV Neurotensin 8-13 4GRV-NTS1 -Neurotensin 8-13 Show 13.04 Single 4N4W SANT-1 4N4W-SMO-SANT-1 Show 13.04 Single 4OR2 FITM 4OR2-mGlu1; mGlu1-FITM Show 13.04 Single 4XEE Neurotensin 4XEE-NTS1 -Neurotensin Show 13.04 Single 4XES Neurotensin 4XES-NTS1 -Neurotensin Show 13.04 Single 6H7N (S)-Xamoterol 6H7N-β1 -(S)-Xamoterol Show 13.04 Single 6OS2 TRV026 6OS2-AT1 -TRV026 Show 13.04 Single 6OSA JMV449 6OSA-NTS1 -JMV449-Gi1/&β;1/&γ;2 Show 13.04 Single 6W2Y PubChem 23727970 6W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970 Show 13.04 Single 6ZG4 HTL0009936 6ZG4-M1 -HTL0009936 Show 13.04 Single 7F55 Bremelanotide 7F55-MC4 -Bremelanotide-Gs/&β;1/&γ;2 Show 13.04 Single 7L0S Neurotensin 7L0S-NTS1 -Neurotensin-Gi1/&β;1/γ1 Show 13.04 Single 7W0L PubChem 122701908 7W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2 Show 13.04 Single 7WCM MBX-2982 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2 Show 13.04 Single 7XMT J-2156 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 Show 13.04 Single 7Y66 BM213 7Y66-C5a1 -BM213-Gi1/&β;1/&γ;2 Show 13.04 Single 8DWC Proenkephalin-A 8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 Show 13.04 Single 8H0Q Gastrin Releasing Peptide 8H0Q-BB2 -Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 Show 13.04 Single 8HK2 C3a anaphylatoxin 8HK2-C3aB -C3a anaphylatoxin-Gi1/&β;1/&γ;2 Show 13.04 Single 8I9L C3a anaphylatoxin 8I9L-C3aB -C3a anaphylatoxin-Go/&β;1/&γ;2 Show 13.04 Single 8IA8 E7 peptide 8IA8-C3aB -E7 peptide-Gi1/&β;1/&γ;2 Show 13.04 Single 8J6D EP141 8J6D-C3aB -EP141-Go/&β;1/&γ;2 Show 13.04 Single 8JGF BAM8-22 8JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 Show 13.04 Single 8JPB Neurotensin 8-13 8JPB-NTS1 -Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2 Show 13.04 Single 8JWZ AB928 8JWZ-A2A -AB928-Na Show 13.04 Consensus adgrg_on Orthosteric Ligand adgrg2_on adgrg3_on Show 13.04 Consensus beta1_on Orthosteric Ligand 7JJO-β1 -Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1 -Dobutamine-Gs/&β;1/&γ;2 Show 13.04 Consensus chemokine_off Orthosteric Ligand cxcr_off Show 13.04 Consensus class-b2_on Orthosteric Ligand adgrg_on Show 13.04 Consensus cxcr4_off Orthosteric Ligand 4RWS-CXCR4-vMIP-II Show 13.04 Consensus cxcr_off Orthosteric Ligand cxcr4_off Show 13.04 Consensus dp2_off Orthosteric Ligand 6D27-DP2 -CAY10471 6D26-DP2 -Fevipiprant Show 13.04 Consensus dp_off Orthosteric Ligand dp2_off Show 13.04 Consensus m4_on Orthosteric Ligand 7TRS-M4 -Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4 -Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4 -2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4 -PubChem 9864275-Gi1/&β;1/&γ;2 Show 13.04 Consensus nts1_on Orthosteric Ligand 6OS9-NTS1 -JMV449-Gi1/&β;1/&γ;2 Show 13.04 Consensus nts_on Orthosteric Ligand nts1_on Show 12.90 Single 6UVA Adrenomedullin-2 6UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3 Show 12.90 Single 7AD3 Alpha-factor mating pheromone 7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2 Show 12.90 Single 7QBC Alpha-factor mating pheromone 7QBC-STE2-Alpha-factor mating pheromone Show 12.90 Consensus gi_class-d Orthosteric Ligand gi_ste Show 12.90 Consensus gi_protein Orthosteric Ligand gi_chemokine gi_chemerin Show 12.90 Consensus gi_ste Orthosteric Ligand 7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2 Show 12.90 Consensus go_class-b1 Orthosteric Ligand go_crf Show 12.90 Consensus go_crf Orthosteric Ligand 7TS0-CRF2 -Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2 Show 12.50 Single 2HPY All-trans-retinal 2HPY-Rhodopsin-All-trans-retinal Show 12.50 Single 3RFM Caffeine 3RFM-A2A -Caffeine Show 12.50 Single 4BUO Neurotensin 4BUO-NTS1 -Neurotensin Show 12.50 Single 4OR2 FITM 4OR2-mGlu1; mGlu1-FITM Show 12.50 Single 4RWS vMIP-II 4RWS-CXCR4-vMIP-II Show 12.50 Single 6K1Q IRL2500 6K1Q-ETB -IRL2500 Show 12.50 Single 6OS9 JMV449 6OS9-NTS1 -JMV449-Gi1/&β;1/&γ;2 Show 12.50 Single 6OY9 All-trans-retinal 6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1 Show 12.50 Single 6UUS Adrenomedullin 6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3 Show 12.50 Single 7DD5 Ca; Ca; Tryptophan; NPS-2143 7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143 Show 12.50 Single 7QBC Alpha-factor mating pheromone 7QBC-STE2-Alpha-factor mating pheromone Show 12.50 Single 7SK7 CCX662 7SK7-ACKR3-CXCL12-CCX662 Show 12.50 Single 7XKD Betahydroxyandrosterone 7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 Show 12.50 Single 7XZ6 APD668 7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 Show 12.50 Single 7Y14 Beta-alanine 7Y14-MRGPRD-Beta-alanine Show 12.50 Single 7Y65 C5a peptide 7Y65-C5a1 -C5a peptide-Gi1/&β;1/&γ;2 Show 12.50 Single 8DPH Lorcaserin 8DPH-5-HT2C -Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 Show 12.50 Single 8JD3 HZR; PEF 8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2 Show 12.50 Single 8JPF Neurotensin 8JPF-NTS1 -Neurotensin-PubChem 118610427 Show 12.50 Consensus adgrg2_on Orthosteric Ligand 7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2 Show 12.50 Consensus c5a1_off_ortoallo Orthosteric Ligand 6C1Q-C5a1 -PMX53-NDT9513727 6C1R-C5a1 -PMX53-Avacopan; Na Show 12.50 Consensus calcitonin_on Orthosteric Ligand ct_on ctlike_on Show 12.50 Consensus gi_neurotensin Orthosteric Ligand 7L0P-NTS1 -Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS1 -JMV449-Gi1/&β;1/&γ;2 Show 12.50 Consensus gs_calcitonin Orthosteric Ligand gs_ct gs_cgrp Show 12.50 Consensus gs_lipid Orthosteric Ligand gs_ffa gs_prostanoid Show 12.50 Consensus hca2_on_allo Orthosteric Ligand 8J6P-HCA2 -Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2 -Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2 Show 12.12 Single 5VAI GLP-1 5VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2 Show 12.00 Single 6C1Q PMX53 6C1Q-C5a1 -PMX53-NDT9513727 Show 12.00 Single 7RKF Fractalkine 7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2 Show 12.00 Single 7RKN Fractalkine 7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2 Show 12.00 Consensus c3a_on Orthosteric Ligand 8HK2-C3aB -C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3aB -E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3aB -EP141-Go/&β;1/&γ;2 8I95-C3aB -EP54-Go/&β;1/&γ;2 Show 12.00 Consensus go_compl-peptide Orthosteric Ligand 8I95-C3aB -EP54-Go/&β;1/&γ;2 8IA2-C5a1 -C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB -C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB -EP141-Go/&β;1/&γ;2 Show 12.00 Consensus gs_adgr Orthosteric Ligand 7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2 Show 12.00 Consensus gs_bombesin Orthosteric Ligand 8H0Q-BB2 -Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB1 -NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 Show 12.00 Consensus gs_class-b2 Orthosteric Ligand gs_adgr Show 12.00 Consensus protein_on Orthosteric Ligand ccr_on chemokine_on gphr_on chemerin_on Show 12.00 Consensus ste2_off Orthosteric Ligand 7QA8-STE2-Peptide Show 11.76 Single 2J4Y 11-cis-Retinal 2J4Y-Rhodopsin-11-cis-Retinal Show 11.76 Single 3OE6 IT1t 3OE6-CXCR4-IT1t Show 11.76 Single 3PQR All-trans-retinal 3PQR-Rhodopsin-All-trans-retinal-Gt(CT) Show 11.76 Single 3UZA GTPL9236 3UZA-A2A -GTPL9236 Show 11.76 Single 4XNW MRS2500 4XNW-P2Y1 -MRS2500 Show 11.76 Single 6LI0 GTPL9804 6LI0-GPR52-GTPL9804 Show 11.76 Single 6LPB PACAP 6LPB-PAC1 -PACAP-Gs/&β;1/&γ;1 Show 11.76 Single 7MT8 All-trans-retinal 7MT8-Rhodopsin-All-trans-retinal-GRK1 Show 11.76 Single 7MT9 All-trans-retinal 7MT9-Rhodopsin-All-trans-retinal-GRK1 Show 11.76 Single 7MTA All-trans-retinal 7MTA-Rhodopsin-All-trans-retinal-GRK1 Show 11.76 Single 7V6A PubChem 9864275 7V6A-M4 -PubChem 9864275-Gi1/&β;1/&γ;2 Show 11.76 Single 7WC5 Psilocin 7WC5-5-HT2A -Psilocin Show 11.76 Single 7Y12 Beta-alanine 7Y12-MRGPRD-Beta-alanine-Gi1/&β;1/&γ;2 Show 11.76 Single 8J6Q Beta-hydroxybutyrate 8J6Q-HCA2 -Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2 Show 11.76 Single 8JXT Histamine 8JXT-H4 -Histamine-PO4-Gi1/&β;1/&γ;2 Show 11.76 Single 8POK Histamine 8POK-H2 -Histamine-Gs/&β;1/&γ;2 Show 11.76 Single 8WC6 2-Phenylethylamine 8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 Show 11.76 Single 8WC9 ZH8651 8WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 Show 11.76 Consensus opsin_on Orthosteric Ligand 6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1 Show 11.76 Consensus p2y1_off Orthosteric Ligand 4XNW-P2Y1 -MRS2500 Show 11.54 Single 4XT1 Fractalkine 4XT1-US28-Fractalkine Show 11.54 Single 6WIV PubChem 52923113; PubChem 52924645 6WIV-GABAB1 , GABAB2 -PubChem 52923113; PubChem 52924645 Show 11.54 Single 7L0R Neurotensin 7L0R-NTS1 -Neurotensin-Gi1/&β;1/&γ;1 Show 11.54 Single 7WIC Somatostatin-14 7WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 Show 11.54 Consensus protein_off Orthosteric Ligand ccr_off chemokine_off gnrh_off Show 11.54 Consensus ste2_off Orthosteric Ligand 7QA8-STE2-Peptide Show 11.43 Consensus pth1_on Orthosteric Ligand 8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 Show 11.11 Single 1L9H 11-cis-Retinal 1L9H-Rhodopsin-11-cis-Retinal Show 11.11 Single 1U19 11-cis-Retinal 1U19-Rhodopsin-11-cis-Retinal Show 11.11 Single 2G87 All-trans-retinal 2G87-Rhodopsin-All-trans-retinal Show 11.11 Single 2I35 11-cis-Retinal 2I35-Rhodopsin-11-cis-Retinal Show 11.11 Single 3AYM All-trans-retinal 3AYM-Rhodopsin-All-trans-retinal Show 11.11 Single 3OE9 IT1t 3OE9-CXCR4-IT1t Show 11.11 Single 3V2W PubChem 51892645 3V2W-S1P1 -PubChem 51892645 Show 11.11 Single 4MQT LY2119620 4MQT-M2 -Iperoxo-LY2119620 Show 11.11 Single 4O9R Cyclopamine 4O9R-SMO-Cyclopamine Show 11.11 Single 5OLV LUAA41063 5OLV-A2A -LUAA41063-Na Show 11.11 Single 6I9K 9-cis-Retinal 6I9K-Rhodopsin-9-cis-Retinal Show 11.11 Single 6U1N LY2119620 6U1N-M2 -LY2119620-Arrestin2 Show 11.11 Single 7CUM Phospholipid 7CUM-GABAB1 , GABAB2 -CGP54626-Phospholipid Show 11.11 Single 7DD5 Ca; Ca; Tryptophan; NPS-2143 7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143 Show 11.11 Single 7DFL Histamine 7DFL-H1 -Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2 Show 11.11 Single 7E2Y Serotonin 7E2Y-5-HT1A -Serotonin-Gi1/&β;1/&γ;2 Show 11.11 Single 7F1Q MIP-1a 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 Show 11.11 Single 7RKM Fractalkine 7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2 Show 11.11 Single 7S8N (R)-Zinc-3573 7S8N-MRGPRX2-(R)-Zinc-3573-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 Show 11.11 Single 7SK5 CXCL12 7SK5-ACKR3-CXCL12 Show 11.11 Single 7V68 Iperoxo 7V68-M4 -Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2 Show 11.11 Single 7VBI Non-Acylated Tirzepatide 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 Show 11.11 Single 7XP6 Strychnine 7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2 Show 11.11 Single 7YFC Histamine 7YFC-H4 -Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 Show 11.11 Single 7YFD Imetit 7YFD-H4 -Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 Show 11.11 Single 7YS6 Serotonin 7YS6-5-HT6 -Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2 Show 11.11 Single 8A2P LUAA47070 8A2P-A2A -LUAA47070-Na Show 11.11 Single 8DPF Lorcaserin 8DPF-5-HT2C -Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 Show 11.11 Single 8H2G Niacin 8H2G-HCA2 -Niacin-Gi1/&β;1/&γ;2 Show 11.11 Single 8HN8 Histamine 8HN8-H4 -Histamine-Gi1/&β;1/&γ;2 Show 11.11 Single 8IJA Niacin 8IJA-HCA2 -Niacin-Gi1/&β;1/&γ;2 Show 11.11 Single 8IOC Gamma-MSH 8IOC-MC3 -Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 Show 11.11 Single 8IY9 Niacin 8IY9-HCA2 -Niacin-Go/&β;1/&γ;2 Show 11.11 Single 8J6Q Compound 9n 8J6Q-HCA2 -Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2 Show 11.11 Single 8JII Compound 9n 8JII-HCA2 -Niacin-Compound 9n-Gi1/&β;1/&γ;2 Show 11.11 Single 8K5B Niacin 8K5B-HCA2 -Niacin Show 11.11 Single 8SG1 Chemerin-9 8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2 Show 11.11 Single 8SZF Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW 8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW Show 11.11 Single 8U4R REGN7663-Fab 8U4R-CXCR4-REGN7663-Fab-Cholesterol Show 11.11 Single 8UNX Epinephrine 8UNX-β2 -Epinephrine-GTP-Gs/&β;1/&γ;2 Show 11.11 Single 8W89 PEA 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 Show 11.11 Single 8WC3 SEP-363856 8WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2 Show 11.11 Single 8X2K 5YM 8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2 Show 11.11 Consensus 5ht4_on Orthosteric Ligand 7XT8-5-HT4 -Serotonin-Gs/&β;1/&γ;2 Show 11.11 Consensus class-t_on Orthosteric Ligand taste2_on Show 11.11 Consensus gq_histamine Orthosteric Ligand 7DFL-H1 -Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2 Show 11.11 Consensus gs_class-t Orthosteric Ligand gs_taste Show 11.11 Consensus gs_taste Orthosteric Ligand 7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2 Show 11.11 Consensus h1_on Orthosteric Ligand 7DFL-H1 -Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2 Show 11.11 Consensus hca2_on_allo Other Ligand 8J6P-HCA2 -Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2 -Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2 Show 11.11 Consensus smo_on_allo Orthosteric Ligand 6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2 Show 11.11 Consensus taste2_on Orthosteric Ligand 7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2 Show 10.81 Single 6E3Y Calcitonin gene-related peptide-1 6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 Show 10.81 Consensus pth_on Orthosteric Ligand pth1_on pth2_on Show 10.71 Single 6VN7 PACAP 6VN7-VPAC1 -PACAP-Gs/&β;1/&γ;2 Show 10.71 Single 7F4D Alpha-MSH 7F4D-MC1 -Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 Show 10.71 Consensus gi_chemerin Orthosteric Ligand 8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2 Show 10.71 Consensus mc5_on Orthosteric Ligand 8INR-MC5 -Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5 -PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 Show 10.53 Single 2Z73 11-cis-Retinal 2Z73-Rhodopsin-11-cis-Retinal Show 10.53 Single 3AYN 9-cis-Retinal 3AYN-Rhodopsin-9-cis-Retinal Show 10.53 Single 3ODU IT1t 3ODU-CXCR4-IT1t Show 10.53 Single 3VG9 ZM241385 3VG9-A2A -ZM241385-Antibody Show 10.53 Single 4QIN SAG1.5 4QIN-SMO-SAG1.5 Show 10.53 Single 5DHH SB-612111 5DHH-NOP-SB-612111 Show 10.53 Single 5OLH Vipadenant 5OLH-A2A -Vipadenant-Na Show 10.53 Single 5U09 Taranabant 5U09-CB1 -Taranabant Show 10.53 Single 5ZKQ ABT-491 5ZKQ-PAF-ABT-491 Show 10.53 Single 6D9H Adenosine 6D9H-A1 -Adenosine-Gi2/&β;1/&γ;2 Show 10.53 Single 6KUY PubChem 145704643 6KUY-α2a -PubChem 145704643 Show 10.53 Single 6LFO Interleukin-8 6LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 Show 10.53 Single 6O3C SAG21k 6O3C-SMO-SAG21k-Cholesterol Show 10.53 Single 6PWC Neurotensin 6PWC-NTS1 -Neurotensin-Arrestin2 Show 10.53 Single 7BR3 Elagolix 7BR3-GnRH1 -Elagolix Show 10.53 Single 7M3E Ca; Ca; Tryptophan; NPS-2143; PO4 7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4 Show 10.53 Single 7M3E Ca; Ca; Tryptophan; NPS-2143; PO4 7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4 Show 10.53 Single 7M3F Ca; Ca; Tryptophan; Cinacalcet; PO4 7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4 Show 10.53 Single 7SIL Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4 7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4 Show 10.53 Single 7SIL Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4 7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4 Show 10.53 Single 7T8X Acetylcholine 7T8X-M2 -Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2 Show 10.53 Single 7T90 Acetylcholine 7T90-M2 -Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2 Show 10.53 Single 8A6C All-trans-retinal 8A6C-Rhodopsin-All-trans-retinal Show 10.53 Single 8A6D All-trans-retinal 8A6D-Rhodopsin-All-trans-retinal Show 10.53 Single 8A6E All-trans-retinal 8A6E-Rhodopsin-All-trans-retinal Show 10.53 Single 8DWH Compound-16 8DWH-MRGPRX1-Compound-16-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 Show 10.53 Single 8GEA Epinephrine 8GEA-β2 -Epinephrine-Gs/&β;1/&γ;2 Show 10.53 Single 8HMP PubChem 69921479 8HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2 Show 10.53 Single 8HOC Imetit 8HOC-H4 -Imetit-Gi1/&β;1/&γ;2 Show 10.53 Single 8J6L Niacin 8J6L-HCA2 -Niacin-Gi1/&β;1/&γ;2 Show 10.53 Single 8J6P Compound 9n 8J6P-HCA2 -Niacin-Compound 9n-Gi1/&β;1/&γ;2 Show 10.53 Single 8JHY Compound 9n 8JHY-HCA2 -Compound 9n-Gi1/&β;1/&γ;2 Show 10.53 Single 8SZF Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW 8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW Show 10.53 Single 8U4P AMD3100 8U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2 Show 10.53 Single 8UO1 Epinephrine 8UO1-β2 -Epinephrine-GTP; Mg-Gs/&β;1/&γ;2 Show 10.53 Consensus 5ht2_on Orthosteric Ligand 5ht2a_on 5ht2c_on Show 10.53 Consensus class-f_off Orthosteric Ligand smo_off Show 10.53 Consensus ct_on Orthosteric Ligand 7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 Show 10.53 Consensus gi_histamine Orthosteric Ligand 8HN8-H4 -Histamine-Gi1/&β;1/&γ;2 8HOC-H4 -Imetit-Gi1/&β;1/&γ;2 Show 10.53 Consensus gnrh1_off Orthosteric Ligand 7BR3-GnRH1 -Elagolix Show 10.53 Consensus gs_histamine Orthosteric Ligand 7YFC-H4 -Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4 -Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 Show 10.53 Consensus h4_on Orthosteric Ligand 7YFC-H4 -Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4 -Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 Show 10.53 Consensus m2_on Orthosteric Ligand 7T8X-M2 -Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2 Show 10.53 Consensus opsin_off Orthosteric Ligand 1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal Show 10.34 Single 5YQZ Glucagon analogue 5YQZ-Glucagon-Glucagon analogue Show 10.34 Single 6NIY Adrenomedullin 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 Show 10.34 Single 6WIV PubChem 52923113; PubChem 52924645 6WIV-GABAB1 , GABAB2 -PubChem 52923113; PubChem 52924645 Show 10.34 Single 7AD3 Alpha-factor mating pheromone 7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2 Show 10.34 Single 7FIM Tirzepatide 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 Show 10.34 Single 7WUI IP15 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2 Show 10.34 Single 8HA0 PTH 8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2 Show 10.34 Single 8HNK CXCL11 8HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2 Show 10.34 Single 8IA2 C5a anaphylatoxin 8IA2-C5a1 -C5a anaphylatoxin-Go/&β;1/&γ;2 Show 10.34 Consensus class-d_on Orthosteric Ligand ste2_on Show 10.34 Consensus compl-peptide_on Orthosteric Ligand c5a1_on c3a_on Show 10.34 Consensus gi_class-d Orthosteric Ligand gi_ste Show 10.34 Consensus gi_ste Orthosteric Ligand 7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2 Show 10.34 Consensus go_class-b Orthosteric Ligand go_class-b1 go_class-b2 Show 10.26 Single 7F16 TIP39 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 Show 10.26 Consensus gs_pth Orthosteric Ligand 8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 Show 10.00 Single 3REY PubChem 5697 3REY-A2A -PubChem 5697 Show 10.00 Single 3UZC PubChem 135566609 3UZC-A2A -PubChem 135566609 Show 10.00 Single 3V2Y PubChem 51892645 3V2Y-S1P1 -PubChem 51892645 Show 10.00 Single 5UVI ZM241385 5UVI-A2A -ZM241385 Show 10.00 Single 6A94 Zotepine 6A94-5-HT2A -Zotepine Show 10.00 Single 6IQL L745870 6IQL-D4 -L745870 Show 10.00 Single 6TPK Retosiban 6TPK-OT-Retosiban Show 10.00 Single 6WJC Muscarinic toxin 7 6WJC-M1 -Atropine-Muscarinic toxin 7 Show 10.00 Single 6X18 GLP-1 6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 Show 10.00 Single 6XBL SAG 6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2 Show 10.00 Single 6ZA8 RTI-3a 6ZA8-NTS1 -RTI-3a Show 10.00 Single 6ZDV PubChem 984073 6ZDV-A2A -PubChem 984073-Na Show 10.00 Single 6ZFZ 77-LH-28-1 6ZFZ-M1 -77-LH-28-1 Show 10.00 Single 6ZIN SR48692 6ZIN-NTS1 -SR48692 Show 10.00 Single 7BB6 Acyclovir triphosphate 7BB6-V2 -Acyclovir triphosphate-Gs/&β;1/&γ;2 Show 10.00 Single 7LLY Oxyntomodulin 7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2 Show 10.00 Single 7M3G Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4 7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4 Show 10.00 Single 7QBI Alpha-factor mating pheromone 7QBI-STE2-Alpha-factor mating pheromone Show 10.00 Single 7T94 Acetylcholine 7T94-M2 -Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 Show 10.00 Single 7TRQ VU0467154 7TRQ-M4 -Iperoxo-VU0467154-Gi1/&β;1/&γ;2 Show 10.00 Single 7TRS Acetylcholine 7TRS-M4 -Acetylcholine-Gi1/&β;1/&γ;2 Show 10.00 Single 7V9M Somatoliberin 7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2 Show 10.00 Single 7WC9 PubChem 162421364 7WC9-5-HT2A -PubChem 162421364 Show 10.00 Single 7XXH 2MeSADP 7XXH-P2Y1 -2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2 Show 10.00 Single 7ZI0 SAG 7ZI0-SMO-SAG-Cholesterol Show 10.00 Single 8DWG ML382 8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 Show 10.00 Single 8E3Y PACAP27 8E3Y-VPAC1 -PACAP27-Gs/&β;1/&γ;2 Show 10.00 Single 8E3Z VIP 8E3Z-VPAC1 -VIP-Gs/&β;1/&γ;2 Show 10.00 Single 8GCM L902688 8GCM-EP4 -L902688-Gi1/&β;1/&γ;2 Show 10.00 Single 8GG8 Epinephrine 8GG8-β2 -Epinephrine-GTP-Gs/&β;1/&γ;2 Show 10.00 Single 8HK5 Complement C5 8HK5-C5a1 -Complement C5-Gi1/&β;1/&γ;2 Show 10.00 Single 8J6P Niacin 8J6P-HCA2 -Niacin-Compound 9n-Gi1/&β;1/&γ;2 Show 10.00 Single 8JER Acipimox 8JER-HCA2 -Acipimox-Go/&β;1/&γ;2 Show 10.00 Single 8JHN MMF 8JHN-HCA2 -MMF-Go/&β;1/&γ;2 Show 10.00 Single 8JIM MMF 8JIM-HCA2 -MMF-Gi1/&β;1/&γ;2 Show 10.00 Single 8JLN T1AM 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 Show 10.00 Single 8K5C Acipimox 8K5C-HCA2 -Acipimox Show 10.00 Single 8UHB RO5256390 8UHB-TA1-RO5256390-Gs/&β;1/&γ;2 Show 10.00 Single 8X7A Treprostinil 8X7A-I2-Treprostinil-Gs/&β;1/&γ;2 Show 10.00 Single 9AXF Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4 9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 Show 10.00 Consensus 5ht2a_off Orthosteric Ligand 6A94-5-HT2A -Zotepine 6WH4-5-HT2A -Methiothepin 7VOE-5-HT2A -Aripiprazole 7VOD-5-HT2A -Cariprazine 7WC8-5-HT2A -Lumateperone 6A93-5-HT2A -Risperidone Show 10.00 Consensus 5ht2a_on Orthosteric Ligand 7RAN-5-HT2A -PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT2A -DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 Show 10.00 Consensus cb1_off Orthosteric Ligand 5TGZ-CB1 -AM6538 5U09-CB1 -Taranabant Show 10.00 Consensus crf2_on Orthosteric Ligand 7TS0-CRF2 -Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2 Show 10.00 Consensus cxcr2_on Orthosteric Ligand 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 Show 10.00 Consensus ghrelin_off Orthosteric Ligand 6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457 Show 10.00 Consensus gi_class-f Orthosteric Ligand gi_frizzled Show 10.00 Consensus gi_frizzled Orthosteric Ligand 6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2 Show 10.00 Consensus glu_on Orthosteric Ligand 6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2 Show 10.00 Consensus gnrh_off Orthosteric Ligand gnrh1_off Show 10.00 Consensus hca_on Orthosteric Ligand hca2_on hca3_on Show 10.00 Consensus hcar_on Orthosteric Ligand hca_on Show 10.00 Consensus m1_off_allo Other Ligand 6WJC-M1 -Atropine-Muscarinic toxin 7 Show 10.00 Consensus nop_off Orthosteric Ligand 4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111 Show 10.00 Consensus ot_off Orthosteric Ligand 6TPK-OT-Retosiban Show 10.00 Consensus s1p1_off Orthosteric Ligand 3V2Y-S1P1 -PubChem 51892645 Show 10.00 Consensus s1p_off Orthosteric Ligand s1p1_off Show 10.00 Consensus vasopressin-ot_off Orthosteric Ligand ot_off Show 10.00 Consensus vpac1_on Orthosteric Ligand 8E3Y-VPAC1 -PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1 -VIP-Gs/&β;1/&γ;2 6VN7-VPAC1 -PACAP-Gs/&β;1/&γ;2 Show 9.68 Single 4XT3 Fractalkine 4XT3-US28-Fractalkine Show 9.68 Single 5UIW 5P7-CCL5 5UIW-CCR5-5P7-CCL5 Show 9.68 Single 6P9Y PACAP 6P9Y-PAC1 -PACAP-Gs/&β;1/&γ;2 Show 9.68 Single 7CZ5 Somatoliberin 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 Show 9.68 Single 7D3S Secretin 7D3S-Secretin-Secretin-Gs/&β;1/&γ;2 Show 9.68 Single 7FIY Tirzepatide 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 Show 9.68 Single 7KI0 Semaglutide 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 Show 9.68 Single 7RA3 GIP 7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2 Show 9.68 Single 8E3X PACAP27 8E3X-PAC1 -PACAP27-Gs/&β;1/&γ;2 Show 9.68 Single 8FLR PTHrP(1-36) 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 Show 9.68 Single 8JIS Peptide-15 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 Show 9.68 Consensus ccr5_off Orthosteric Ligand 5UIW-CCR5-5P7-CCL5 Show 9.68 Consensus ghrh_on Orthosteric Ligand 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 Show 9.68 Consensus glp1_on_allo Orthosteric Ligand 6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2 Show 9.52 Single 4DAJ Tiotropium 4DAJ-M3 -Tiotropium Show 9.52 Single 4U16 N-Methyl Scopolamine 4U16-M3 -N-Methyl Scopolamine Show 9.52 Single 5DHG PubChem 25001412 5DHG-NOP-PubChem 25001412 Show 9.52 Single 5DSG Tiotropium 5DSG-M4 -Tiotropium Show 9.52 Single 5T04 Neurotensin 5T04-NTS1 -Neurotensin Show 9.52 Single 5TGZ AM6538 5TGZ-CB1 -AM6538 Show 9.52 Single 5YC8 N-Methyl Scopolamine 5YC8-M2 -N-Methyl Scopolamine Show 9.52 Single 5ZK8 N-Methyl Scopolamine 5ZK8-M2 -N-Methyl Scopolamine Show 9.52 Single 5ZKC N-Methyl Scopolamine 5ZKC-M2 -N-Methyl Scopolamine Show 9.52 Single 6GPS MK0812 6GPS-CCR2-MK0812 Show 9.52 Single 6IIV Daltroban 6IIV-TP-Daltroban Show 9.52 Single 6WHA DB13948 6WHA-5-HT2A -DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 Show 9.52 Single 7M3J NPS-2143; PO4 7M3J-CaS-NPS-2143; PO4 Show 9.52 Single 7SK8 CXCL12 7SK8-ACKR3-CXCL12-CCX662 Show 9.52 Single 7WQ3 Galanin 7WQ3-GAL1 -Galanin-Gi1/&β;1/&γ;2 Show 9.52 Single 7YAC Paltusotine 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2 Show 9.52 Single 8I7V Acipimox 8I7V-HCA2 -Acipimox-Gi1/&β;1/&γ;2 Show 9.52 Single 8JII Niacin 8JII-HCA2 -Niacin-Compound 9n-Gi1/&β;1/&γ;2 Show 9.52 Single 8XJL PGF2-alpha 8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2 Show 9.52 Consensus gal1_on Orthosteric Ligand 7WQ3-GAL1 -Galanin-Gi1/&β;1/&γ;2 Show 9.52 Consensus gi_galanin Orthosteric Ligand 7WQ3-GAL1 -Galanin-Gi1/&β;1/&γ;2 Show 9.52 Consensus go_muscarinic Orthosteric Ligand 8E9X-M4 -2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M2 -Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2 Show 9.52 Consensus hca3_on Orthosteric Ligand 8IHJ-HCA3 -Acifran-Gi1/&β;1/&γ;2 Show 9.52 Consensus histamine_on Orthosteric Ligand h1_on h4_on Show 9.52 Consensus m4_off Orthosteric Ligand 5DSG-M4 -Tiotropium Show 9.52 Consensus prostanoid_off Orthosteric Ligand ep_off tp_off dp_off Show 9.52 Consensus tp_off Orthosteric Ligand 6IIV-TP-Daltroban 6IIU-TP-Ramatroban Show 9.38 Single 6P9X Corticoliberin 6P9X-CRF1 -Corticoliberin-Gs/&β;1/&γ;2 Show 9.38 Single 6VCB GLP-1 6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2 Show 9.38 Single 7DTY GIP 7DTY-GIP-GIP-Gs/&β;1/&γ;2 Show 9.38 Single 7S1M Ex4-D-Ala 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 Show 9.38 Single 7VQX PACAP27 7VQX-VPAC1 -PACAP27-Gs/&β;1/&γ;2 Show 9.38 Single 7VVJ PTHrP(1-36) 7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 Show 9.38 Single 8FU6 Glucagon derivative ZP3780 8FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 Show 9.09 Single 4JKV Taladegib (LY2940680) 4JKV-SMO-Taladegib (LY2940680) Show 9.09 Single 4WW3 All-trans-retinal 4WW3-Rhodopsin-All-trans-retinal Show 9.09 Single 5WIU Nemonapride 5WIU-D4 -Nemonapride Show 9.09 Single 5WIV Nemonapride 5WIV-D4 -Nemonapride-Na Show 9.09 Single 5YHL PubChem 135121352 5YHL-EP4 -PubChem 135121352 Show 9.09 Single 5YWY ONO-AE3-208 5YWY-EP4 -ONO-AE3-208 Show 9.09 Single 6B3J Exendin-P5 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 Show 9.09 Single 6GPX MK0812 6GPX-CCR2-MK0812 Show 9.09 Single 6LFM Interleukin-8 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 Show 9.09 Single 6LML Glucagon 6LML-Glucagon-Glucagon Show 9.09 Single 6PB1 Urocortin 6PB1-CRF2 -Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2 Show 9.09 Single 6WZG Secretin 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 Show 9.09 Single 6Z4S SR48692 6Z4S-NTS1 -SR48692 Show 9.09 Single 7BB7 Acyclovir triphosphate 7BB7-V2 -Acyclovir triphosphate-Gs/&β;1/&γ;2 Show 9.09 Single 7C4S S1P 7C4S-S1P3 -S1P Show 9.09 Single 7D68 GLP-2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 Show 9.09 Single 7EW3 S1P 7EW3-S1P3 -S1P-Gi1/&β;1/&γ;2 Show 9.09 Single 7KI1 Taspoglutide 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 Show 9.09 Single 7M3G Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4 7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4 Show 9.09 Single 7M3J NPS-2143; PO4 7M3J-CaS-NPS-2143; PO4 Show 9.09 Single 7SIN NPS-2143 7SIN-CaS-NPS-2143 Show 9.09 Single 7SIN NPS-2143 7SIN-CaS-NPS-2143 Show 9.09 Single 7VOE Aripiprazole 7VOE-5-HT2A -Aripiprazole Show 9.09 Single 7VV4 Cortistatin-14 7VV4-MRGPRX2-Cortistatin-14 Show 9.09 Single 7VVL PTH 7VVL-PTH1-PTH-Gs/&β;1/&γ;2 Show 9.09 Single 7YXA ONO-5430608 7YXA-S1P5 -ONO-5430608 Show 9.09 Single 8E9Z Iperoxo 8E9Z-M3 -Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 Show 9.09 Single 8EA0 Iperoxo 8EA0-M3 -Iperoxo Show 9.09 Single 8EFB Oliceridine 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 Show 9.09 Single 8FLT M-PTH(1-14) 8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2 Show 9.09 Single 8GD9 Rivenprost 8GD9-EP4 -Rivenprost-Gs/&β;1/&γ;2 Show 9.09 Single 8HAF PTHrP(1-36) 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2 Show 9.09 Single 8HNL PS372424 8HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2 Show 9.09 Single 8IHJ Acifran 8IHJ-HCA3 -Acifran-Gi1/&β;1/&γ;2 Show 9.09 Single 8JPC Neurotensin 8-13 8JPC-NTS1 -Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2 Show 9.09 Consensus crf_on Orthosteric Ligand crf2_on crf1_on Show 9.09 Consensus d4_off Orthosteric Ligand 5WIU-D4 -Nemonapride Show 9.09 Consensus d4_off_allo Orthosteric Ligand 5WIV-D4 -Nemonapride-Na Show 9.09 Consensus ep4_off Orthosteric Ligand 5YWY-EP4 -ONO-AE3-208 5YHL-EP4 -PubChem 135121352 Show 9.09 Consensus ep_off Orthosteric Ligand ep4_off Show 9.09 Consensus glp1_on Orthosteric Ligand 6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 Show 9.09 Consensus m2_off Orthosteric Ligand 5ZKB-M2 -AF-DX 384 5ZKC-M2 -N-Methyl Scopolamine 5ZK3-M2 -Quinuclidinyl benzilate hydrobromide Show 9.09 Consensus secretin_on Orthosteric Ligand 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 Show 9.09 Consensus vpac2_on Orthosteric Ligand 7VQX-VPAC1 -PACAP27-Gs/&β;1/&γ;2 Show 8.82 Single 7DUQ GLP-1 7DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2 Show 8.82 Consensus gip_on Orthosteric Ligand 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 Show 8.82 Consensus gs_crf Orthosteric Ligand 6P9X-CRF1 -Corticoliberin-Gs/&β;1/&γ;2 Show 8.70 Single 5V57 TC114 5V57-SMO-TC114 Show 8.70 Single 6Z4Q SR142948A 6Z4Q-NTS1 -SR142948A Show 8.70 Single 7AUE Setmelanotide 7AUE-MC4 -Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2 Show 8.70 Single 7F1T MIP-1a 7F1T-CCR5-MIP-1a Show 8.70 Single 7M8W 15r-Methyl-Prostaglandin D2 7M8W-DP2 -15r-Methyl-Prostaglandin D2-Na Show 8.70 Single 7P2L 4YI 7P2L-mGlu5 -4YI Show 8.70 Single 7S8M Cortistatin-14 7S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2 Show 8.70 Single 7SK7 CXCL12 7SK7-ACKR3-CXCL12-CCX662 Show 8.70 Single 7T2H Lofentanil 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 Show 8.70 Single 7XBD Galanin 7XBD-GAL2 -Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 Show 8.70 Single 8EFL SR17018 8EFL-μ-SR17018-Gi1/&β;1/&γ;2 Show 8.70 Single 8IHB GSK256073 8IHB-HCA2 -GSK256073-Gi1/&β;1/&γ;2 Show 8.70 Single 8IHH LUF6283 8IHH-HCA2 -LUF6283-Gi1/&β;1/&γ;2 Show 8.70 Single 8IYW GSK256073 8IYW-HCA2 -GSK256073-Go/&β;1/&γ;2 Show 8.70 Single 8JT6 (R)-IHCH-7179 8JT6-5-HT1A -(R)-IHCH-7179-Gi1/&β;1/&γ;2 Show 8.70 Single 8X79 MRE-269 8X79-I2-MRE-269-Gs/&β;1/&γ;2 Show 8.70 Single 8XJM Latanoprost 8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2 Show 8.57 Single 6WPW Glucagon derivative ZP3780 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 Show 8.57 Single 7VBH Peptide-20 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 Show 8.57 Single 8FLS Abaloparatide 8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2 Show 8.57 Single 8FLU Long-acting PTH 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 Show 8.57 Consensus glp_on Orthosteric Ligand glp1_on glp2_on Show 8.33 Single 6A93 Risperidone 6A93-5-HT2A -Risperidone Show 8.33 Single 6AK3 Dinoprostone IPGE2 6AK3-EP3 -Dinoprostone IPGE2 Show 8.33 Single 6C1R PMX53 6C1R-C5a1 -PMX53-Avacopan; Na Show 8.33 Single 6CM4 Risperidone 6CM4-D2 -Risperidone Show 8.33 Single 6IIU Ramatroban 6IIU-TP-Ramatroban Show 8.33 Single 6W2Y PubChem 23727970 6W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970 Show 8.33 Single 6YVR NTS8-13 6YVR-NTS1 -NTS8-13 Show 8.33 Single 7DFP Spiperone 7DFP-D2 -Spiperone Show 8.33 Single 7V35 Peptide-20 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 Show 8.33 Single 7VVM PTH 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 Show 8.33 Single 7W0N Elabela 7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2 Show 8.33 Single 7WCN AR231453 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 Show 8.33 Single 7XJK Galanin 7XJK-GAL2 -Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 Show 8.33 Single 7XZ5 Lysophosphatidylcholine 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 Show 8.33 Single 8GCP PGE2 8GCP-EP4 -PGE2-Gi1/&β;1/&γ;2 Show 8.33 Single 8JIP MEDI0382 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 Show 8.33 Single 8JIR SAR425899 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 Show 8.33 Consensus d2_off Orthosteric Ligand 6CM4-D2 -Risperidone 6LUQ-D2 -Haloperidol 7DFP-D2 -Spiperone Show 8.33 Consensus galanin_on Orthosteric Ligand gal2_on gal1_on Show 8.33 Consensus gi_prostanoid Orthosteric Ligand 8GCP-EP4 -PGE2-Gi1/&β;1/&γ;2 8GDC-EP3 -PGE2-Gi1/&β;1/&γ;2 8GCM-EP4 -L902688-Gi1/&β;1/&γ;2 Show 8.33 Consensus gpr119_on Orthosteric Ligand 7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2 Show 8.33 Consensus nts1_off Orthosteric Ligand 6Z4Q-NTS1 -SR142948A 6Z4S-NTS1 -SR48692 Show 8.33 Consensus nts_off Orthosteric Ligand nts1_off Show 8.33 Consensus prostanoid_on Orthosteric Ligand ep_on fpa_on Show 8.11 Single 7Y36 Teriparatide 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 Show 8.11 Single 8FLQ PTH 8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 Show 8.11 Consensus gs_glucagon Orthosteric Ligand 6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 Show 8.11 Consensus gs_vip-pacap Orthosteric Ligand 8E3Y-VPAC1 -PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1 -PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1 -VIP-Gs/&β;1/&γ;2 6M1I-PAC1 -PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1 -PACAP-Gs/&β;1/&γ;2 Show 8.00 Single 7LLL Exendin-4 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 Show 8.00 Single 7SHF PI; PE 7SHF-GPR158-PI; PE-B5; RGS7 Show 8.00 Single 7U2K C6-guano 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 Show 8.00 Single 7X8R BOC5 7X8R-GLP-1-BOC5-Gs/&β;1/&γ;2 Show 8.00 Single 8HN1 Toxin AdTx1 8HN1-Alpha1A-Toxin AdTx1 Show 8.00 Single 8IQ6 Latanoprost 8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 Show 8.00 Single 8IUL Latanoprost 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 Show 8.00 Single 8K2X CXCL10 8K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2 Show 8.00 Single 8XJO U46619 8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 Show 8.00 Consensus ep4_on Orthosteric Ligand 7D7M-EP4 -Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP4 -PGE2-Gi1/&β;1/&γ;2 8GD9-EP4 -Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4 -L902688-Gs/&β;1/&γ;2 Show 8.00 Consensus fpa_on Orthosteric Ligand 8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 Show 8.00 Consensus gs_prostanoid Orthosteric Ligand 8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP2 -PGE2-Gs/&β;1/&γ;2 7CX3-EP2 -Taprenepag-Gs/&β;1/&γ;2 7D7M-EP4 -Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP2 -Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 Show 7.89 Single 8JIU SAR425899 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 Show 7.89 Consensus gs_class-b Orthosteric Ligand gs_class-b1 gs_class-b2 Show 7.69 Single 5EE7 MK0893 5EE7-Glucagon-MK0893 Show 7.69 Single 6KNM JN241-9 6KNM-Apelin-JN241-9 Show 7.69 Single 7S8L Cortistatin-14 7S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 Show 7.69 Single 7X8S WB4-24 7X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2 Show 7.69 Single 8INR Alpha-MSH 8INR-MC5 -Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 Show 7.69 Single 8IQ4 Carboprost 8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 Show 7.69 Single 8IUM Tafluprost acid 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 Show 7.50 Consensus glucagon_on Orthosteric Ligand gip_on glu_on secretin_on ghrh_on glp_on Show 7.41 Single 7RTB Peptide-19 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 Show 7.41 Single 8JIQ Peptide-15 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 Show 7.41 Single 8U4O CXCL12 8U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2 Show 7.41 Consensus alpha1a_off Orthosteric Ligand 7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1 Show 7.32 Consensus class-b1_on Orthosteric Ligand glucagon_on calcitonin_on vip-pacap_on pth_on crf_on Show 7.14 Single 6WHC Glu16 analog of GCG 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2 Show 7.14 Single 7SHE PI; PE 7SHE-GPR158-PI; PE Show 6.98 Consensus gs_class-b1 Orthosteric Ligand gs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf Show 6.90 Single 7VVN PTH 7VVN-PTH1-PTH-Gs/&β;1/&γ;2 Show 6.90 Single 7XA3 CCL2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 Show 6.90 Consensus ccr2_on Orthosteric Ligand 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 Show 6.67 Single 4A4M All-trans-retinal 4A4M-Rhodopsin-All-trans-retinal-Gt(CT) Show 6.67 Single 5EN0 All-trans-retinal 5EN0-Rhodopsin-All-trans-retinal-Gt(CT) Show 6.67 Single 6M1I PACAP 6M1I-PAC1 -PACAP-Gs/&β;1/&γ;2 Show 6.67 Single 7FIN Peptide-20; GGL 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 Show 6.67 Single 8TLM Anti-murine CCR8 antibody 8TLM-CCR8-Anti-murine CCR8 antibody Show 6.67 Single 8WCB Cyclohexylammonium ion 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 Show 6.67 Consensus ccr1_on Orthosteric Ligand 7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 Show 6.67 Consensus ccr8_off Orthosteric Ligand 8TLM-CCR8-Anti-murine CCR8 antibody Show 6.67 Consensus pca1_on Orthosteric Ligand 6M1I-PAC1 -PACAP-Gs/&β;1/&γ;2 Show 6.45 Single 7TRY Urocortin 7TRY-CRF2 -Urocortin-chim(NtGi1-G11)/&β;1/&γ;2 Show 6.45 Single 7VL9 CCL15(26-92) 7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 Show 6.45 Single 7Y35 Abaloparatide 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 Show 6.25 Single 3PXO All-trans-retinal 3PXO-Rhodopsin-All-trans-retinal Show 6.25 Single 5DYS All-trans-retinal 5DYS-Rhodopsin-All-trans-retinal Show 6.25 Single 6FJ3 PTH 6FJ3-PTH1-PTH Show 6.25 Single 6NBF Long-acting PTH analog 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 Show 6.25 Single 7V68 PubChem 57664406 7V68-M4 -Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2 Show 6.25 Single 7WC4 Serotonin 7WC4-5-HT2A -Serotonin Show 6.25 Single 8HAO PTH 8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2 Show 6.25 Single 8HQM NPGLY 8HQM-GPR132-NPGLY-Gi1/&β;1/&γ;2 Show 6.25 Consensus class-c_on Other Ligand gabab_on mglu_on Show 6.25 Consensus ctlike_on Orthosteric Ligand 6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2 Show 6.25 Consensus gabab_off Other Ligand 7C7S-GABAB1 , GABAB2 -CGP54626 7CUM-GABAB1 , GABAB2 -CGP54626-Phospholipid 6W2X-GABAB1 , GABAB2 -PubChem 5311042-PubChem 23727970 Show 6.06 Single 5NX2 GLP-1 (Truncated) 5NX2-GLP-1-GLP-1 (Truncated) Show 6.06 Consensus ccr_on Orthosteric Ligand ccr5_on ccr6_on ccr1_on ccr2_on ccr8_on Show 6.06 Consensus glp2_on Orthosteric Ligand 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 Show 5.88 Single 6NBH Long-acting PTH analog 6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 Show 5.88 Single 6XBM 25(S)-Epoxycholesterol 6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2 Show 5.88 Single 7MTB All-trans-retinal 7MTB-Rhodopsin-All-trans-retinal-GRK1 Show 5.88 Single 7VVK PTH 7VVK-PTH1-PTH-Gs/&β;1/&γ;2 Show 5.88 Single 8HVI NOX-6-7 8HVI-GPR132-NOX-6-7-Gi1/&β;1/&γ;2 Show 5.88 Single 8IWM 2-Phenylethylamine 8IWM-TAAR9-2-Phenylethylamine Show 5.88 Single 8U4Q REGN7663-Fab 8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/&β;1/&γ;2 Show 5.88 Single 8WC5 Tetramethylammonium ion 8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2 Show 5.88 Consensus sensory_on Orthosteric Ligand opsin_on Show 5.71 Single 7RBT Tirzepatide 7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2 Show 5.71 Consensus gip_on_allo Orthosteric Ligand 7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2 Show 5.56 Single 2ZIY 11-cis-Retinal 2ZIY-Rhodopsin-11-cis-Retinal Show 5.56 Single 3C9M 11-cis-Retinal 3C9M-Rhodopsin-11-cis-Retinal Show 5.56 Single 3OE8 IT1t 3OE8-CXCR4-IT1t Show 5.56 Single 6D32 Cyclopamine 6D32-SMO-Cyclopamine-Cyclopamine Show 5.56 Single 6OIK LY2119620 6OIK-M2 -Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2 Show 5.56 Single 7TYH Calcitonin-1 7TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2 Show 5.56 Single 8DPI Lorcaserin 8DPI-5-HT2C -Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 Show 5.56 Single 8IW7 2-Phenylethylamine 8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 Show 5.56 Single 8WG8 Peptide 8WG8-Glucagon-Peptide-chim(NtGi1-Gs)/&β;1/&γ;2 Show 5.56 Consensus gip_on_allo Other Ligand 7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2 Show 5.41 Consensus vip-pacap_on Orthosteric Ligand vpac1_on vpac2_on pca1_on Show 5.26 Single 5TE5 20-Methanoretinal 5TE5-Rhodopsin-20-Methanoretinal Show 5.26 Single 7UL2 SR48692 7UL2-NTS1 -SR48692-Na Show 5.26 Single 7XKF Betahydroxyandrosterone 7XKF-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 Show 5.26 Single 8FX5 Xanomeline 8FX5-M4 -Xanomeline-Xanomeline-Gi1/&β;1/&γ;2 Show 5.26 Single 8IHI Acifran 8IHI-HCA2 -Acifran-Gi1/&β;1/&γ;2 Show 5.26 Single 8JIL Niacin 8JIL-HCA2 -Niacin-Gi1/&β;1/&γ;2 Show 5.26 Single 8JIT MEDI0382 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 Show 5.26 Single 8W8B SEP-363856 8W8B-5-HT1A -SEP-363856-Gi1/&β;1/&γ;2 Show 5.26 Consensus go_chemokine Orthosteric Ligand 6WWZ-CCR6-CCL20-Go/&β;1/&γ;2 Show 5.26 Consensus go_protein Orthosteric Ligand go_chemokine Show 5.26 Consensus m4_on_allo Other Ligand 7TRP-M4 -Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4 -Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4 -Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2 Show 5.26 Consensus nts1_off_allo Orthosteric Ligand 7UL2-NTS1 -SR48692-Na Show 5.00 Single 4BWB Neurotensin 4BWB-NTS1 -Neurotensin Show 5.00 Single 6RNK NF-56-EJ40 6RNK-Succinate-NF-56-EJ40 Show 5.00 Single 6WWZ CCL20 6WWZ-CCR6-CCL20-Go/&β;1/&γ;2 Show 5.00 Single 7X2C Fenoldopam 7X2C-D1 -Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2 Show 5.00 Single 8G94 CD69 8G94-S1P1 -CD69-Gi1/&β;1/&γ;2 Show 5.00 Single 8IHK Acifran 8IHK-HCA3 -Acifran Show 5.00 Single 8IJB Acipimox 8IJB-HCA2 -Acipimox-Gi1/&β;1/&γ;2 Show 5.00 Consensus ccr6_on Orthosteric Ligand 6WWZ-CCR6-CCL20-Go/&β;1/&γ;2 Show 5.00 Consensus smo_on_allo Other Ligand 6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2 Show 4.76 Single 6WH4 Methiothepin 6WH4-5-HT2A -Methiothepin Show 4.76 Single 6ZG9 GSK1034702 6ZG9-M1 -GSK1034702 Show 4.76 Single 7S8P MS47134 7S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 Show 4.76 Single 7TYO Calcitonin 7TYO-CT-Calcitonin-Gs/&β;1/&γ;2 Show 4.76 Single 7VVO PTH 7VVO-PTH1-PTH-Gs/&β;1/&γ;2 Show 4.76 Single 7XJJ Galanin 7XJJ-GAL1 -Galanin-Go/&β;1/&γ;2 Show 4.76 Single 8HNM VUF11222 8HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2 Show 4.76 Single 8K2W AMG487 8K2W-CXCR3-AMG487 Show 4.76 Consensus go_galanin Orthosteric Ligand 7XJJ-GAL1 -Galanin-Go/&β;1/&γ;2 Show 4.65 Consensus gs_ct Orthosteric Ligand 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3 Show 4.55 Single 5NDD AZ8838; Na 5NDD-PAR2-AZ8838; Na Show 4.55 Single 6D27 CAY10471 6D27-DP2 -CAY10471 Show 4.55 Single 6Z10 PubChem 154585554 6Z10-Succinate-PubChem 154585554 Show 4.55 Single 7WC8 Lumateperone 7WC8-5-HT2A -Lumateperone Show 4.55 Single 8I7W GSK256073 8I7W-HCA2 -GSK256073-Gi1/&β;1/&γ;2 Show 4.55 Single 8JT8 (R)-IHCH-7179 8JT8-5-HT2A -(R)-IHCH-7179 Show 4.55 Single 8K5D GSK256073 8K5D-HCA2 -GSK256073 Show 4.55 Consensus hcar_off Orthosteric Ligand succinate_off Show 4.55 Consensus succinate_off Orthosteric Ligand 6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554 Show 4.35 Single 5CGC HTL14242 5CGC-mGlu5 -HTL14242 Show 4.35 Single 5T1A PubChem 68764898; PubChem 12093170 5T1A-CCR2-PubChem 68764898; PubChem 12093170 Show 4.35 Single 6M9T Misoprostol-FA 6M9T-EP3 -Misoprostol-FA Show 4.35 Single 8GDA L902688 8GDA-EP4 -L902688-Gs/&β;1/&γ;2 Show 4.35 Single 8GDC PGE2 8GDC-EP3 -PGE2-Gi1/&β;1/&γ;2 Show 4.35 Single 8SZI Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW 8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2 Show 4.35 Consensus ccr2_off_allo Other Ligand 5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812 Show 4.35 Consensus ep3_on Orthosteric Ligand 8GDC-EP3 -PGE2-Gi1/&β;1/&γ;2 Show 4.17 Single 7XJL Spexin 7XJL-GAL2 -Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 Show 4.17 Single 8GDB PGE2 8GDB-EP4 -PGE2-Gs/&β;1/&γ;2 Show 4.17 Single 8IUK PGF2-alpha 8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 Show 4.17 Single 8JD5 BQI; HZE; PEF 8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2 Show 4.00 Single 5X33 BIIL260 5X33-BLT1 -BIIL260 Show 4.00 Single 7D7M Dinoprostone 7D7M-EP4 -Dinoprostone-Gs/&β;1/&γ;1 Show 4.00 Single 7K15 MKD046 7K15-BLT1 -MKD046-Na Show 4.00 Single 7SHE PI; PE 7SHE-GPR158-PI; PE Show 4.00 Single 7WQ4 Galanin 7WQ4-GAL2 -Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 Show 4.00 Single 8SZH Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW 8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2 Show 4.00 Consensus blt1_off Orthosteric Ligand 7K15-BLT1 -MKD046-Na Show 4.00 Consensus blt_off Orthosteric Ligand blt1_off Show 4.00 Consensus ep_on Orthosteric Ligand ep4_on ep2_on ep3_on Show 3.85 Single 5CGD HTL14242 5CGD-mGlu5 -HTL14242 Show 3.85 Single 6M1H Maxadilan 6M1H-PAC1 -Maxadilan-Gs/&β;1/&γ;2 Show 3.85 Single 7CX4 Evatanepag 7CX4-EP2 -Evatanepag-Gs/&β;1/&γ;2 Show 3.85 Consensus ep2_on Orthosteric Ligand 7CX4-EP2 -Evatanepag-Gs/&β;1/&γ;2 7CX2-EP2 -PGE2-Gs/&β;1/&γ;2 7CX3-EP2 -Taprenepag-Gs/&β;1/&γ;2 Show 3.85 Consensus gal2_on Orthosteric Ligand 7WQ4-GAL2 -Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2 -Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 Show 3.85 Consensus gs_galanin Orthosteric Ligand 7WQ4-GAL2 -Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2 -Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 Show 3.57 Single 7CX3 Taprenepag 7CX3-EP2 -Taprenepag-Gs/&β;1/&γ;2 Show 3.57 Single 7VLA CCL15(27-92) 7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2 Show 3.45 Single 7SHF PI; PE 7SHF-GPR158-PI; PE-B5; RGS7 Show 3.33 Single 7XNA CYN154806 7XNA-SST2-CYN154806 Show 3.33 Consensus ccr_off Orthosteric Ligand ccr5_off ccr8_off Show 3.33 Consensus sst2_off Orthosteric Ligand 7XNA-SST2-CYN154806 Show 3.03 Single 6NBI Long-acting PTH analog 6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 Show 2.94 Single 6LMK Glucagon 6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 Show 2.86 Single 7TYW Calcitonin-1 7TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1 Show 2.78 Single 7TYF Amylin 7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1 Show 2.78 Single 7TYI Amylin 7TYI-CT-Amylin-Gs/&β;1/&γ;2 Show 2.78 Single 7TYN Calcitonin-1 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 Show 2.63 Single 7TZF Amylin 7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3 Show 2.63 Single 8F0K Pramlintide analogue san385 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3 Show 2.56 Single 7TYY Calcitonin-1 7TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2 Show 2.56 Single 9AUC Calcitonin gene-related peptide-1 9AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 Show 2.44 Single 8F2A Pramlintide analogue san385 8F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3 Show 2.27 Single 8F2B Pramlintide analogue san45 8F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3 Show 2.17 Single 8F0J Pramlintide analogue san45 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2