Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
1G.HN.38 0.547222402
2G.hns1.01 7.231394154
3G.S1.02 7.10889576
4G.S2.02 1.62111505
5G.S2.06 6.203064179
6G.S3.03 6.778508
7G.S3.04 7.685284167
8G.s3h2.03 5.01361419
9G.H2.01 5.73917419
10G.H2.06 6.6963619
11G.H2.07 5.45206719
12G.h2s4.01 10.7742409
13G.S4.04 5.19278409
14G.H3.01 3.58667609
15G.H3.09 5.894076189
16G.H3.13 10.66365186
17G.H3.17 10.966515
18G.S5.05 4.59241699
19G.S5.07 3.835699
20G.HG.13 2.71833407
21G.HG.16 4.12639404
22G.hgh4.02 4.03556448
23G.hgh4.04 2.34472446
24G.hgh4.05 10.5271546
25G.hgh4.11 4.03156545
26G.hgh4.20 4.81667543
27G.hgh4.21 6.03361404
28G.H4.03 3.18306404
29G.H4.08 6.274543
30G.H4.10 9.64467547
31G.H4.12 6.37667544
32G.H4.13 4.94556543
33G.H4.14 5.88911545
34G.H4.15 8.40389408
35G.S6.02 10.1081408
36G.S6.05 7.47178545
37G.H5.03 4.74583499
38G.H5.05 5.24083475
39G.H5.08 6.94311578
40G.H5.15 3.90889578
41G.H5.17 10.18165195
42G.H5.25 3.56861408
43b.1x1 2.91861404
44b.1x4 3.38417408
45b.1x16 1.52611404
46b.h2x4 2.14472403
47b.lhb1x6 4.11133563
48b.l1x3 8.41074639
49b.l1x6 11.3091519
50b.b2x1 5.99044518
51b.b2x5 6.27778637
52b.b3x3 4.64722408
53b.l3x2 7.599724159
54b.b4x2 5.58139408
55b.b4x6 9.55032739
56b.l4x3 5.60889436
57b.b5x3 6.05317739
58b.b5x7 6.20944407
59b.l5x1 4.725115148
60b.l5x5 9.23378509
61b.b6x1 5.33972419
62b.b6x5 4.68583406
63b.b7x1 6.19444404
64b.b8x4 6.078225146
65b.l9x3 7.501115119
66b.l9x6 6.2237618
67b.b10x5 4.95093609
68b.l11x2 7.361785119
69b.b12x6 9.666856118
70b.b13x7 8.11556557
71b.l13x3 8.01889659
72b.l13x6 7.24194419
73b.l13x7 5.26111459
74b.b15x1 6.86222659
75b.b15x2 7.87972416
76b.l15x1 6.43639417
77b.l15x2 6.26778559
78b.b16x4 9.69028456
79b.b16x5 6.22694405
80b.b16x6 9.00333758
81b.b16x7 7.419174229
82b.b17x5 8.0825417
83b.b17x7 8.97667418
84b.l17x3 8.58746719
85b.l17x6 8.19289519
86b.b18x3 4.90306418
87b.b18x5 5.76515
88b.l18x1 7.42222686
89b.l18x2 5.65333487
90b.l18x3 8.31139485
91b.b19x2 7.37963616
92b.b19x4 6.46222418
93b.l19x1 6.85444419
94b.l19x2 8.08956519
95b.b20x4 10.0946618
96b.b20x6 6.79381716
97b.b21x1 7.39963617
98b.b21x5 6.2075404
99b.b21x7 6.26259605
100b.b22x5 6.15093687
101b.l22x5 6.91741669
102b.b23x2 5.02583486
103b.b23x6 7.627416127
104b.l23x1 5.47616
105b.l23x2 5.460834128
106b.b24x4 7.759724126
107b.b24x5 3.52083405
108b.b24x6 7.530284128
109b.l24x3 4.5475405
110b.l25x3 8.9854109
111b.l25x6 13.54518
112b.b27x3 6.21417408
113b.l27x1 11.686719
114b.l27x2 8.224444109
115b.b28x3 4.78622537
116b.b28x4 7.376114106
117b.b28x6 8.759785109
118g.h1x1 2.47278402
119g.l1x2 3.34512
120g.l1x4 6.16444518
121g.h2x11 10.1958486
122g.ctx3 5.84093669
123g.ctx6 3.09178566
124g.ctx14 6.49378539
125g.ctx15 7.61083439
126g.ctx16 5.71873738
127Lig 7.531711320
1281x39 4.99055407
1291x46 4.53972407
1301x50 5.78444409
1311x60 4.45267506
132I1x49 6.04444406
1332x42 6.28178508
1342x46 4.66844529
1352x50 6.64644529
1362x57 5.06556427
1372x59 4.52333405
138E1x50 5.636197138
139E1x52 4.997224136
1403x32 8.90917427
1413x43 5.47583429
1423x50 8.41333429
143I2x51 7.24022577
144I2x53 6.504455207
1454x50 4.298529
1464x58 4.657785235
147E2.H164 4.78778405
1485x39 5.27607
1495x47 9.69667528
1505x50 3.18778409
1515x54 5.61556428
1525x58 5.65648629
1535x62 5.196675247
1546x41 3.51556428
1556x44 4.67984729
1566x48 7.0954728
1576x51 7.31278627
1586x52 10.7709527
1596x54 4.56361405
1606x59 2.10444405
1617x34 5.19556424
1627x38 4.99972426
1637x39 8.23356525
1647x42 7.36937727
1657x45 7.09583429
1667x49 6.47611429
1677x53 5.89844529
1688x50 5.97704609
1698x54 3.89178507
170NT.F20 0.647778400
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1G.HN.47 b.b5x3 11.35883.76NoYes059
2G.HN.47 b.b4x2 10.93844.07333NoYes058
3b.l26x5 g.ctx15 23.50216.52111NoYes059
4b.l26x5 g.ctx4 36.10655.59NoNo057
5g.ctx3 g.ctx4 36.52474.83YesNo097
6b.l22x2 g.ctx3 78.10083.84222NoYes019
7b.l22x2 g.ctx2 78.30753.75NoNo013
8g.ctx2 g.h2x15 78.72075.33222NoNo036
9g.h2x11 g.h2x15 79.13419.3589YesNo066
10b.l18x1 g.h2x11 39.66354.46889YesYes866
11b.b22x5 b.l18x1 40.802611.9089YesYes876
12b.b22x5 b.b23x2 80.860611.0956YesYes876
13b.b21x7 b.b23x2 81.26423.51778YesYes056
14b.b21x7 b.b24x6 83.63911.0389YesYes058
15b.b23x6 b.b24x6 84.11658.25444YesYes1278
16b.b23x6 b.l23x2 85.13824.85556YesYes1278
17b.l21x7 b.l23x2 85.74826.22333NoYes058
18b.l21x7 b.l23x1 85.94653.80333NoYes056
19G.H3.17 b.l23x1 43.06767.81556YesYes156
20G.H3.17 b.l27x1 43.21417.49778YesYes159
21b.l18x2 g.h2x11 39.6595.71444YesYes876
22b.b22x5 b.l18x2 39.75884.01222YesYes877
23b.l23x1 b.l25x6 43.067611.6478YesYes168
24b.l25x6 b.l27x1 43.213821.8789YesYes189
25b.b2x1 b.l27x1 86.42097.39444YesYes189
26b.b2x1 b.b6x1 86.42437.18444YesYes189
27b.b6x1 b.l9x6 86.55946.91667YesYes198
28G.H2.07 b.l9x6 1004.82444YesYes198
29G.H2.04 G.H2.07 1008.22111NoYes099
30G.H2.04 G.H3.08 1006.47778NoNo098
31G.H3.08 G.S4.04 1006.21889NoYes089
32G.H3.09 G.S4.04 55.45475.71778YesYes099
33G.H3.09 G.H4.15 55.08967.97778YesYes098
34G.H3.06 G.H4.15 1008.93333NoYes068
35G.H3.06 G.H4.14 1003.97667NoYes065
36G.H4.10 G.H4.14 1008.29222YesYes475
37G.H4.10 G.HG.15 1003.34889YesNo477
38G.HG.15 G.s4h3.04 1005.50667NoNo078
39G.HG.07 G.s4h3.04 1007.96111NoNo098
40G.HG.07 G.s4h3.02 1004.59NoNo099
41G.HG.03 G.s4h3.02 1003.83667NoNo069
42G.HG.03 G.s5hg.01 1005.32667NoNo069
43G.S5.07 G.s5hg.01 1005.13111YesNo099
44G.S4.05 G.S5.07 36.50033.94222NoYes979
45G.S4.05 G.S5.05 36.483.63889NoYes979
46G.H5.07 G.S5.05 1003.83222NoYes099
47G.H5.07 G.S4.03 1004.15333NoNo097
48G.S1.04 G.S4.03 1004.75778NoNo077
49G.S1.04 G.S3.03 1005.81889NoYes078
50G.S1.02 G.S3.03 99.13255.40667YesYes068
51G.S4.04 G.S4.06 54.7344.36889YesNo097
52G.H4.15 G.S4.06 54.75476.55556YesNo087
53G.S5.07 G.s6h5.01 36.64074.87333YesNo999
54G.S5.05 G.s6h5.01 36.487.35YesNo999
55G.H1.04 G.S5.07 36.50033.46111NoYes979
56G.H1.04 G.S5.05 36.483.34889NoYes979
57G.H2.06 b.l9x6 28.70014.24556YesYes198
58G.H2.06 b.l17x6 14.23668.45333YesYes199
59G.H2.06 b.l19x1 14.17774.91556YesYes199
60G.H5.15 G.S1.02 98.73194.27222YesYes786
61G.H5.15 G.H5.19 98.57344.12556YesNo088
62G.H5.19 G.H5.22 96.63813.71111NoNo084
63G.H5.22 G.H5.23 96.56046.51333NoNo044
643x50 G.H5.23 96.454116.8044YesNo094
65b.l17x5 b.l17x6 14.1373.92778NoYes169
66b.l17x5 b.l19x2 28.14473.43222NoYes169
67b.l17x3 b.l19x2 26.84814.9YesYes199
68b.b20x6 b.l17x3 24.37573.64556YesYes169
69b.b17x7 b.b20x6 22.028212.6222YesYes186
70b.b17x7 b.b21x1 20.2664.38YesYes187
71b.l17x5 b.l19x1 14.12425.07111NoYes169
72g.ctx3 g.ctx5 35.9333.92111YesNo699
73b.lhb1x11 g.ctx5 35.72494.23778NoNo049
74b.b25x7 b.lhb1x11 35.51594.08222NoNo074
75b.b25x7 b.b28x6 23.605617.21NoYes079
76b.b28x4 b.b28x6 11.9067.21778YesYes1069
77b.b28x5 g.ctx16 11.77234.46444NoYes358
78b.b4x6 b.b5x3 15.137611.9867YesYes399
79b.b1x6 b.b4x6 10.51221.0067NoYes399
80b.b24x3 b.b25x7 11.70175.46667NoNo057
81b.b24x3 b.b27x3 11.07283.56778NoYes058
82b.b27x3 b.l25x3 17.52578.21333YesYes089
83b.l25x3 b.l27x2 25.0255.18111YesYes1099
84b.b27x3 b.b28x6 11.0738.49YesYes089
85b.b3x2 b.b4x6 10.50955.94667NoYes359
86b.b2x5 b.b3x2 10.71849.36333YesNo375
87b.b21x1 g.h1x14 10.56323.46333YesNo079
88b.l26x3 b.l26x5 12.39726.46667NoNo075
89b.l26x1 b.l26x3 11.97676.90555NoNo377
90b.b2x5 b.l26x1 11.767511.1878YesNo377
91b.l25x4 b.l27x2 23.76655.91222NoYes059
92I1x49 b.l25x4 22.51254.62YesNo065
933x36 6x48 21.19024.94111NoYes278
946x44 6x48 61.98086.12556YesYes298
953x43 6x44 40.11534.73444YesYes299
963x43 7x53 40.52275.99111YesYes299
973x50 7x53 54.43727.08556YesYes299
985x54 6x44 40.34597.04778YesYes289
995x54 5x58 40.36034.78889YesYes289
1003x50 5x58 41.78955.03YesYes299
1015x47 6x44 16.26943.69222YesYes289
1025x47 6x52 14.922323.3389YesYes287
1036x52 Lig 29.16727.61111YesYes270
1046x48 6x52 14.92476.79444YesYes287
1053x36 Lig 14.58846.57778NoYes270
1066x48 6x51 25.57233.67556YesYes287
1076x51 Lig 14.594213.2944YesYes270
1083x33 Lig 18.364710.2156NoYes060
1095x43 Lig 11.5638.00778NoYes070
1107x42 Lig 25.07643.42YesYes270
1112x46 2x50 12.17534.52444YesYes299
1122x46 7x53 13.35343.51889YesYes299
1138x50 I1x50 14.414312.1789YesNo099
114I1x49 I1x50 15.04489.14222YesNo069
1152x59 3x28 17.76725.41333YesNo055
1162x60 3x28 44.3857.73333NoNo065
1172x60 7x42 42.61545.92889NoYes267
1182x59 E1x52 12.67275.34556YesYes056
119E1x50 E1x52 12.67276.34556YesYes1386
1203x28 E1x50 25.34468.85111NoYes058
1213x33 5x39 10.88354.56667NoYes067
1225x39 5x43 10.882911.4467YesNo077
1232x62 2x65 20.25030.512222NoNo045
1242x62 E1x52 22.79782.03778NoYes046
1252x65 NT.F20 15.15530.557778NoYes050
126b.b1x6 b.b28x5 11.56293.96556NoNo395
127g.ctx15 g.ctx16 12.81694.65333YesYes398
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
3x32Lig13.77672YesYes7010
3x33Lig10.21560NoYes6010
3x36Lig6.577782NoYes7010
E2.L190Lig11.66110NoYes0010
5x43Lig8.007780NoYes7010
5x461Lig4.581110NoYes6010
6x51Lig13.29442YesYes7010
6x52Lig7.611112YesYes7010
6x55Lig8.451112NoYes6010
7x42Lig3.422YesYes7010
2x563x327.138892NoYes8721
2x567x425.722NoYes8721
2x577x394.783332YesYes7522
2x577x425.428892YesYes7721
2x607x395.155562NoYes6522
2x607x425.928892NoYes6721
3x323x363.927782YesNo7711
3x327x4210.79332YesYes7711
3x334x574.645560NoNo6712
3x335x394.566670NoYes6712
3x366x484.941112NoYes7812
3x375x4616.928890NoNo6621
5x395x4311.44670YesNo7721
5x446x525.868890NoYes7721
5x446x554.801110NoNo7621
5x476x5223.33892YesYes8721
6x486x513.675562YesYes8721
6x486x526.794442YesYes8721
6x516x5210.24112YesYes7711
6x516x556.846672YesNo7611
6x517x345.597782YesYes7412
6x517x384.221112YesYes7611
7x347x384.222222YesYes4621
7x387x427.902222YesYes6711
7x397x4212.39222YesYes5721
E2x52Lig3.398890NoYes5010
7x38Lig3.653332YesYes6010
3x29Lig3.263330NoYes5010

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
92.31Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
92.31Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
85.71Single6H7JIsoprenaline6H7J-β1-Isoprenaline
85.71Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
85.71Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
85.71Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
84.62Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
84.62Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
84.62Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
84.62Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
84.62Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
84.62Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
84.62Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
84.62Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
84.62Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
84.62Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
84.62Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
84.62Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
84.62Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
84.62Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
84.62Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
84.62Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
84.62Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
84.62Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
84.62Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
84.62Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
84.62Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
84.62Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
84.62Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
84.62Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
84.62Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
84.62Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
84.62Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
80.00Single4LDEBI1671074LDE-β2-BI167107
78.57Single2RH1S-Carazolol2RH1-β2-S-Carazolol
78.57Single2Y03Isoprenaline2Y03-β1-Isoprenaline
78.57Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
78.57Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
78.57Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
78.57Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
78.57Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
78.57Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
78.57Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
78.57Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
78.57Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
78.57Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
78.57Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
78.57Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
78.57Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
78.57Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
78.57Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
78.57Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
78.57Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
78.57Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
78.57Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
78.57Consensusamine_offonOrthosteric Ligandamine_off amine_on
78.57Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
78.57Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
78.57Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
78.57Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
78.57Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
78.57Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
78.57Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
78.57Consensustrace-amine_onOrthosteric Ligandta1_on
76.92Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
76.92Single6PS0S-Carazolol6PS0-β2-S-Carazolol
76.92Single6PS4ICI118-5516PS4-β2-ICI118-551
76.92Single6PS5S-Propranolol6PS5-β2-S-Propranolol
76.92Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
76.92Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
76.92Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
76.92Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
76.92Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
76.92Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
76.92Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
76.92Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
76.92Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
76.92Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
76.92Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
76.92Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
76.92Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
76.92Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
76.92Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
76.92Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
76.92Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
76.92Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
76.92Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
76.92Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
76.92Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
76.92Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
76.92Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
76.92Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
76.92Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
76.92Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
75.00Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
75.00Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
73.33Single2YDVNECA2YDV-A2A-NECA
73.33Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
73.33Single4UHRCGS216804UHR-A2A-CGS21680
73.33Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
73.33Single5D5AS-Carazolol5D5A-β2-S-Carazolol
73.33Single5D5BS-Carazolol5D5B-β2-S-Carazolol
73.33Single5G53NECA5G53-A2A-NECA-Gs
73.33Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
73.33Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
73.33Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
73.33Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
73.33Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
73.33Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
73.33Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
73.33Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
73.33Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
73.33Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
73.33Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
73.33Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
73.33Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
73.33Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
73.33Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
73.33Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
73.33Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
73.33Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
71.43Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
71.43Single2Y04Salbutamol2Y04-β1-Salbutamol
71.43Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
71.43Single3NY8ICI118-5513NY8-β2-ICI118-551
71.43Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
71.43Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
71.43Single4GBRS-Carazolol4GBR-β2-S-Carazolol
71.43Single6H7MSalbutamol6H7M-β1-Salbutamol
71.43Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
71.43Single6PS1Timolol6PS1-β2-Timolol
71.43Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
71.43Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
71.43Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
71.43Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
71.43Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
71.43Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
71.43Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
71.43Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
71.43Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
71.43Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
71.43Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
71.43Single8JJOAlprenolol8JJO-β2-Alprenolol
71.43Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
71.43Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
71.43Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
71.43Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
71.43Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
71.43Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
71.43Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
71.43Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
71.43Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
71.43Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
71.43Single9CHXS-Carazolol9CHX-β2-S-Carazolol
71.43Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
71.43Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
71.43Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
71.43Consensusdopamine_offOrthosteric Ligandd2_off d3_off
71.43Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
70.59Single3NY9ICI118-5513NY9-β2-ICI118-551
70.59Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
69.23Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
69.23Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
69.23Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
69.23Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
69.23Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
69.23Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
69.23Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
69.23Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
69.23Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
69.23Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
69.23Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
69.23Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
69.23Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
69.23Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
69.23Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
69.23Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
69.23Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
69.23Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
69.23Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
69.23Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
69.23Consensusalpha2_offOrthosteric Ligandalpha2c_off
69.23Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
68.75Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
68.75Single3D4STimolol3D4S-β2-Timolol
68.75Single4AMIBucindolol4AMI-β1-Bucindolol
68.75Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
68.75Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
68.75Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
68.75Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
68.75Single8JJ8Formoterol8JJ8-β2-Formoterol
68.75Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
68.75Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
68.75Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
68.75Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
68.75Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
68.75Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
66.67Single2YCWS-Carazolol2YCW-β1-S-Carazolol
66.67Single5D6LS-Carazolol5D6L-β2-S-Carazolol
66.67Single5JQHS-Carazolol5JQH-β2-S-Carazolol
66.67Single5X7DS-Carazolol5X7D-β2-S-Carazolol-PubChem 129318963
66.67Single6E67BI1671076E67-β2-BI167107-Gs (fused)
66.67Single7WC6LSD7WC6-5-HT2A-LSD
66.67Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
66.67Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
66.67Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
66.67Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
66.67Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
66.67Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
66.67Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
66.67Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
66.67Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
66.67Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
64.71Single6H7LDobutamine6H7L-β1-Dobutamine
64.71Single6IBLArformoterol6IBL-β1-Arformoterol
64.71Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
64.71Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
64.71Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
64.71Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
64.71Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
64.71Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
64.29Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
64.29Single6TPGEMPA6TPG-OX2-EMPA
64.29Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
64.29Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
64.29Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
64.29Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
64.29Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
64.29Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
64.29Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
64.29Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
64.29Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
64.29Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
64.29Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
64.29Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
64.29Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
64.29Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
64.29Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
64.29Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
64.29Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
64.29Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
64.29Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
64.29Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
64.29Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
64.29Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
64.29Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
64.29Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
64.29Consensusalpha1_onOrthosteric Ligandalpha1a_on
64.29Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
64.29Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
64.29Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
62.50Single3P0GBI1671073P0G-β2-BI167107
62.50Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
62.50Single6J21Aprepitant6J21-NK1-Aprepitant
62.50Single6TQ7SB-3348676TQ7-OX1-SB-334867
62.50Single6WGTLSD6WGT-5-HT2A-LSD
62.50Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
62.50Single8E0GBU728E0G-μ-BU72
62.50Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
62.50Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
61.54Single3PBLEticlopride3PBL-D3-Eticlopride
61.54Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
61.54Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
61.54Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
61.54Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
61.54Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
61.54Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
61.54Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
61.54Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
61.54Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
61.54Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
61.54Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
61.54Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
61.11Single4UG2CGS216804UG2-A2A-CGS21680
60.00Single2Y02Carmoterol2Y02-β1-Carmoterol
60.00Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
60.00Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
60.00Single4QKX35V4QKX-β2-35V
60.00Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
60.00Single7BU7BI1671077BU7-β1-BI167107
60.00Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
60.00Single7UL4Alvimopan7UL4-μ-Alvimopan
60.00Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
60.00Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
60.00Single7WC7Lisuride7WC7-5-HT2A-Lisuride
60.00Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
60.00Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
60.00Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
60.00Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
60.00Single8PJKST1718PJK-5-HT1A-ST171-t7m-Gi1/β1/γ1
60.00Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
60.00Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
60.00Single8X64Desloratadine8X64-H1-Desloratadine
60.00Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
60.00Consensus5ht5_onOrthosteric Ligand5ht5a_on
60.00Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
60.00Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
60.00Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
60.00Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
60.00Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
60.00Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
60.00Consensusalpha2_onOrthosteric Ligandalpha2b_on
60.00Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
60.00Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
60.00Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
60.00Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
58.82Single4RWADIPP-NH24RWA-δ-DIPP-NH2
58.82Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
58.82Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
58.82Single6MXTSalmeterol6MXT-β2-Salmeterol
58.82Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
58.82Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
58.82Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
58.82Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
58.82Single7YITNalfurafine7YIT-κ-Nalfurafine
58.82Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
58.82Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
58.82Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
58.82Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
58.82Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
58.82Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
58.82Consensusalpha1_offOrthosteric Ligandalpha1a_off
58.82Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
58.82Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
58.82Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
58.82Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
57.89Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
57.89Single4IARErgotamine4IAR-5-HT1B-Ergotamine
57.89Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
57.89Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
57.89Single8PKMBefiradol8PKM-5-HT1A-Befiradol-t7m-Gi1/β1/γ1
57.89Single8WDTphotoNECA8WDT-A2A-photoNECA
57.89Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
57.89Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
57.89Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
57.14Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
57.14Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
57.14Single6TODEMPA6TOD-OX1-EMPA-Na
57.14Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
57.14Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
57.14Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
57.14Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
57.14Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
57.14Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
57.14Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
57.14Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
57.14Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
57.14Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
57.14Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
57.14Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
57.14Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
56.25Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
56.25Single5C1MBU725C1M-μ-BU72
56.25Single5TVNLSD5TVN-5-HT2B-LSD
56.25Single5WIUNemonapride5WIU-D4-Nemonapride
56.25Single5WIVNemonapride5WIV-D4-Nemonapride-Na
56.25Single5WQCEMPA5WQC-OX2-EMPA
56.25Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
56.25Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
56.25Single6PS6Timolol6PS6-β2-Timolol
56.25Single7C61Ergotamine7C61-5-HT1B-Ergotamine
56.25Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/β1/γ2
56.25Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
56.25Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
56.25Single8JXSPF-61428JXS-D1-PF-6142
56.25Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
56.25Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
55.56Single5X93K-87945X93-ETB-K-8794
55.56Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
55.56Single7UM4AS26747237UM4-5-HT5A-AS2674723
55.56Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
55.56Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
55.56Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
55.56Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
55.56Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
55.56Consensusendothelin_offOrthosteric Ligandetb_off
55.56Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
55.00Single6HLOAprepitant6HLO-NK1-Aprepitant
55.00Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
53.85Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
53.85Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
53.85Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
53.85Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
53.85Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
53.33Single2YDOAdenosine2YDO-A2A-Adenosine
53.33Single4ZJCSB-6740424ZJC-OX1-SB-674042
53.33Single6A94Zotepine6A94-5-HT2A-Zotepine
53.33Single6KUXRS-799486KUX-α2a-RS-79948
53.33Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
53.33Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
53.33Single6TPNHTL66416TPN-OX2-HTL6641
53.33Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
53.33Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
53.33Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
53.33Single7UL3Famotidine7UL3-H2-Famotidine
53.33Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
53.33Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
53.33Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
53.33Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
53.33Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
53.33Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
53.33Single8YN8Proxyfan8YN8-H3-Proxyfan-Go1/β1/γ2
53.33Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
53.33Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
53.33Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
53.33Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
52.94Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
52.94Single4U15Tiotropium4U15-M3-Tiotropium
52.94Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
52.94Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
52.94Single6J20Aprepitant6J20-NK1-Aprepitant
52.94Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
52.94Single6OL9Tiotropium6OL9-M5-Tiotropium
52.94Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
52.94Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
52.94Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
52.94Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
52.94Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
52.94Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
52.94Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
52.94Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
52.94Single8XVLZibotentan8XVL-ETA-Zibotentan
52.94Single9F33FOB02-04A9F33-D3-FOB02-04A-Go1/β1/γ2
52.94Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
52.94Consensusa2_onOrthosteric Liganda2b_on
52.94Consensusa2_on_gpOrthosteric Liganda2b_on_gp
52.94Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
52.94Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
52.94Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
52.94Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
52.94Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
52.94Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
52.94Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
52.94Consensustachykinin_offOrthosteric Ligandnk1_off
52.63Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
52.63Single8X5YAstemizole8X5Y-H1-Astemizole
52.63Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
52.63Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
52.38Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
50.00Single2Y01Dobutamine2Y01-β1-Dobutamine
50.00Single4EJ4Naltrindole4EJ4-δ-Naltrindole
50.00Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
50.00Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
50.00Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
50.00Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
50.00Single5CXVTiotropium5CXV-M1-Tiotropium
50.00Single5DHGC-355DHG-NOP-C-35
50.00Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
50.00Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
50.00Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
50.00Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
50.00Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
50.00Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
50.00Single6TOTLemborexant6TOT-OX1-Lemborexant
50.00Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
50.00Single7SRQLSD7SRQ-5-HT2B-LSD
50.00Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
50.00Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
50.00Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
50.00Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
50.00Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
50.00Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
50.00Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
50.00Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
50.00Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
50.00Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
50.00Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
50.00Single8JJLOlodaterol8JJL-β2-Olodaterol
50.00Single8JXRLSD8JXR-D1-LSD
50.00Single8T1WCVN4248T1W-GPR6-CVN424
50.00Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
50.00Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
50.00Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
50.00Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
50.00Single8X63Mepyramine8X63-H1-Mepyramine
50.00Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
50.00Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
50.00Single8YN7Immethridine8YN7-H3-Immethridine-Go1/β1/γ2
50.00Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
50.00Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
50.00Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
50.00Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
50.00Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
50.00Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
50.00Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
50.00Consensusa3_onOrthosteric Liganda3a_on
50.00Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
50.00Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
50.00Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
50.00Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
50.00Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
50.00Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
50.00Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
50.00Consensushistamine_offOrthosteric Ligandh1_off
50.00Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
50.00Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
47.83Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
47.83Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
47.62Single3QAKUK-4320973QAK-A2A-UK-432097
47.62Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
47.37Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
47.37Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
47.37Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
47.37Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
47.37Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
47.37Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
47.37Single7EZCUKA7EZC-A2A-UKA
47.37Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
47.37Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
47.37Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
47.37Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
47.37Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/β1/γ2
47.37Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
47.37Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
47.37Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
47.37Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
47.37Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
47.37Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
47.06Single2Y00Dobutamine2Y00-β1-Dobutamine
47.06Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
47.06Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
47.06Single5XPRBosentan5XPR-ETB-Bosentan
47.06Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
47.06Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
47.06Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
47.06Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
47.06Single6TP6Filorexant6TP6-OX1-Filorexant
47.06Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
47.06Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
47.06Single7W41PD1762527W41-BB2-PD176252
47.06Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
47.06Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
47.06Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
47.06Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
47.06Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
47.06Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
47.06Single8ZMFA1L108ZMF-5-HT2C-A1L10
47.06Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
47.06Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
47.06Single9F34FOB02-04A9F34-D3-FOB02-04A-Go1/β1/γ2
47.06Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
47.06Consensusa3_on_gpOrthosteric Liganda3a_on_gp
47.06Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
47.06Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
47.06Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
47.06Consensusbombesin_offOrthosteric Ligandbb2_off
47.06Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
47.06Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
47.06Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
46.67Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
46.67Single5WS3EMPA5WS3-OX2-EMPA
46.67Single6AKXA4R6AKX-CCR5-A4R
46.67Single6B73MP11046B73-κ-MP1104
46.67Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
46.67Single6ME2Ramelteon6ME2-MT1-Ramelteon
46.67Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
46.67Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
46.67Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
46.67Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
46.67Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
46.67Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
46.67Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
46.67Single8IWESpermidine8IWE-TA9-Spermidine
46.67Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
46.67Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
46.67Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
46.67Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
46.67Consensusorexin_offOrthosteric Ligandox2_off ox1_off
46.67Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
46.67Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
46.15Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
46.15Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
46.15Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
46.15Single9CHUNoradrenaline9CHU-β2-Noradrenaline
46.15Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
46.15Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
45.83Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
45.45Single5WF5UK-4320975WF5-A2A-UK-432097
45.45Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
45.45Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
45.45Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
45.00Single5WF6UK-4320975WF6-A2A-UK-432097
45.00Single5ZTYAM102575ZTY-CB2-AM10257
45.00Single6PT3DPI-2876PT3-δ-DPI-287
45.00Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
45.00Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
45.00Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
45.00Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
45.00Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
45.00Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
45.00Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
44.44Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
44.44Single4DJHJDTic4DJH-κ-JDTic
44.44Single5V54Methiothepin5V54-5-HT1B-Methiothepin
44.44Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
44.44Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
44.44Single6E59L-7607356E59-NK1-L-760735
44.44Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
44.44Single7B6WCyclazosin7B6W-α1b-Cyclazosin
44.44Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
44.44Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
44.44Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
44.44Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
44.44Single8EA0Iperoxo8EA0-M3-Iperoxo
44.44Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
44.44Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
44.44Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
44.44Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
44.44Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
44.44Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
44.44Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
44.44Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
44.44Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
44.44Consensus5ht1_offOrthosteric Ligand5ht1b_off
44.44Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
44.44Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
44.44Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
44.00Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
44.00Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
43.75Single3RZECidoxepin3RZE-H1-Cidoxepin
43.75Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
43.75Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
43.75Single4MBSMaraviroc4MBS-CCR5-Maraviroc
43.75Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
43.75Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
43.75Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
43.75Single6IQLL7458706IQL-D4-L745870
43.75Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
43.75Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
43.75Single6V9SGTPL114036V9S-OX1-GTPL11403
43.75Single6VI4JDTic6VI4-κ-JDTic
43.75Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
43.75Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
43.75Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
43.75Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
43.75Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
43.75Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
43.75Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
43.75Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
43.75Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
43.75Single8K5CAcipimox8K5C-HCA2-Acipimox
43.75Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
43.75Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
43.75Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
43.75Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
43.75Single9BJKNaloxone9BJK-μ-Naloxone-NAM
43.75Consensushca_onOrthosteric Ligandhca2_on
43.48Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
43.48Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
43.48Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
43.48Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
43.48Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
43.48Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
42.86Single3UZAGTPL92363UZA-A2A-GTPL9236
42.86Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
42.86Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
42.86Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
42.86Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
42.86Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
42.86Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
42.86Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
42.86Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
42.86Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
42.86Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
42.86Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
42.86Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
42.86Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
42.86Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
42.86Consensus5ht2_onOrthosteric Ligand5ht2b_on
42.86Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
42.86Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
42.86Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
42.86Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
42.86Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
42.11Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
42.11Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
42.11Single6CM4Risperidone6CM4-D2-Risperidone
42.11Single6ZG4HTL00099366ZG4-M1-HTL0009936
42.11Single7DFPSpiperone7DFP-D2-Spiperone
42.11Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
42.11Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
42.11Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
42.11Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
42.11Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
42.11Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
42.11Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
42.11Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
42.11Single8JWY2-1188JWY-A2A-2-118
42.11Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
42.11Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
42.11Single8XYIVUF106618XYI-CXCR3-VUF10661
42.11Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
42.11Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
42.11Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
42.11Consensuslpa_offOrthosteric Ligandlpa1_off
42.11Consensusorexin_onOrthosteric Ligandox2_on
42.11Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
42.11Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
42.11Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
42.11Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
41.18Single4DAJTiotropium4DAJ-M3-Tiotropium
41.18Single4MQSIperoxo4MQS-M2-Iperoxo
41.18Single4U14Tiotropium4U14-M3-Tiotropium
41.18Single5DHHSB-6121115DHH-NOP-SB-612111
41.18Single5DSGTiotropium5DSG-M4-Tiotropium
41.18Single6DRXLisuride6DRX-5-HT2B-Lisuride
41.18Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
41.18Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
41.18Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
41.18Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
41.18Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
41.18Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
41.18Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
41.18Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
41.18Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
41.18Single8CU6LJ-45178CU6-A2A-LJ-4517
41.18Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
41.18Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
41.18Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
41.18Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
41.18Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
41.18Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
41.18Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
41.18Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
41.18Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
41.18Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
41.18Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
41.18Consensushca_on_gpOrthosteric Ligandhca2_on_gp
41.18Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
41.18Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
41.18Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
40.91Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
40.91Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
40.91Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
40.91Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
40.91Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
40.91Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
40.74Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
40.74Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
40.74Consensusbombesin_onOrthosteric Ligandbb2_on
40.74Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
40.74Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
40.00Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
40.00Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
40.00Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
40.00Single6HLLCP999946HLL-NK1-CP99994
40.00Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
40.00Single6TP4ACT-4622066TP4-OX1-ACT-462206
40.00Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
40.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
40.00Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
40.00Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
40.00Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
40.00Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
40.00Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
40.00Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
40.00Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
40.00Single8K5BNiacin8K5B-HCA2-Niacin
40.00Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
40.00Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go1/β1/γ2
40.00Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
40.00Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
40.00Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
40.00Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
40.00Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
40.00Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
40.00Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
40.00Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
39.13Single6PT2KGCHM076PT2-δ-KGCHM07
39.13Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
39.13Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
39.13Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
39.13Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
39.13Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
39.13Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
39.13Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
38.89Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
38.89Single6HLPNetupitant6HLP-NK1-Netupitant
38.89Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
38.89Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
38.89Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
38.89Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
38.89Single7SINNPS-21437SIN-CaS-NPS-2143
38.89Single7SINNPS-21437SIN-CaS-NPS-2143
38.89Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
38.89Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
38.89Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
38.89Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
38.89Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
38.89Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
38.89Single8S4DCMF-0198S4D-Apelin-CMF-019
38.89Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
38.89Single8TF5Oleic acid8TF5-GPR6-Oleic acid
38.89Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
38.89Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
38.89Single8XYKVUF106618XYK-CXCR3-VUF10661-Go1/β1/γ2
38.89Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
38.89Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
38.89Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
38.89Consensusadenosine_offOrthosteric Liganda1_off a2_off
38.89Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
38.89Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
38.89Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
38.46Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
38.46Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
38.46Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
38.46Single8PWNTheophylline8PWN-A2A-Theophylline
38.46Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
38.46Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
38.10Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
38.10Single7SK9CCX6627SK9-ACKR3-CCX662
38.10Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
38.10Single7XN9L-054,5227XN9-SST2-L-054,522
38.10Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
38.10Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
38.10Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
37.50Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
37.50Single4S0VSuvorexant4S0V-OX2-Suvorexant
37.50Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
37.50Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
37.50Single6AKYMaraviroc6AKY-CCR5-Maraviroc
37.50Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
37.50Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
37.50Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
37.50Single6TPJSuvorexant6TPJ-OX2-Suvorexant
37.50Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
37.50Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
37.50Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
37.50Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
37.50Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
37.50Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
37.50Single7XRRLemborexant7XRR-OX2-Lemborexant
37.50Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
37.50Single8GNGIstradefylline8GNG-A2A-Istradefylline
37.50Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
37.50Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
37.50Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
37.50Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
37.50Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
37.50Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
37.50Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
37.50Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
37.50Single8Y0HVUF114188Y0H-CXCR3-VUF11418
37.50Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
37.50Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ
37.50Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
37.50Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
37.50Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
37.50Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
37.50Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
37.50Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
37.50Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
37.50Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
37.04Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
36.84Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
36.84Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
36.84Single5XR8AM8415XR8-CB1-AM841
36.84Single5XRAAM115425XRA-CB1-AM11542
36.84Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
36.84Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
36.84Single7TUYGSK682753A7TUY-GPR183-GSK682753A
36.84Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
36.84Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
36.84Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
36.84Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
36.84Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
36.84Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
36.84Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
36.84Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
36.84Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
36.84Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
36.84Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
36.84Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
36.84Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
36.84Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
36.84Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
36.84Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
36.36Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
36.36Single7F8XNN90567F8X-CCKA-NN9056
36.36Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
36.36Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
36.36Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
36.36Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
36.36Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
36.36Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
36.36Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
36.36Consensuslpl_onOrthosteric Ligands1p_on lpa_on
36.36Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
36.36Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
36.36Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
36.00Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
36.00Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
36.00Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
36.00Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
35.71Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
35.71Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
35.71Single8A2OTheophylline8A2O-A2A-Theophylline-Na
35.71Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
35.71Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
35.71Consensussensory_onOrthosteric Ligandopsins_on
35.29Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
35.29Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
35.29Single5IU7Q274563465IU7-A2A-Q27456346-Na
35.29Single5IUBQ274563445IUB-A2A-Q27456344-Na
35.29Single5JTBZM-2413855JTB-A2A-ZM-241385
35.29Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
35.29Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
35.29Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
35.29Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
35.29Single6AQFZM-2413856AQF-A2A-ZM-241385
35.29Single6TP3Nemorexant6TP3-OX1-Nemorexant
35.29Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
35.29Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
35.29Single7AROLUF58337ARO-A2A-LUF5833-Na
35.29Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
35.29Single7T32ZM-2413857T32-A2A-ZM-241385
35.29Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
35.29Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
35.29Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
35.29Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
35.29Single8IHKAcifran8IHK-HCA3-Acifran
35.29Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
35.29Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
35.29Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
35.29Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
35.29Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
35.29Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
35.29Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
35.29Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
35.29Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
35.29Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
35.29Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
35.29Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
35.29Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
35.29Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
35.29Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
35.29Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
35.29Consensusa2_offOrthosteric Liganda2a_off
35.29Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
35.29Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
35.29Consensusopsins_offOrthosteric Ligandrhodopsin_off
35.29Consensussensory_offOrthosteric Ligandopsins_off
35.00Single6A93Risperidone6A93-5-HT2A-Risperidone
35.00Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
35.00Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
35.00Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
35.00Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
35.00Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
35.00Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
35.00Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
35.00Single8JWZAB9288JWZ-A2A-AB928-Na
35.00Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
35.00Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
35.00Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
35.00Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
35.00Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
35.00Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
35.00Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
35.00Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
35.00Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
35.00Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
35.00Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
35.00Consensuslpl_offOrthosteric Ligands1p_off lpa_off
35.00Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
34.78Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
34.78Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
34.78Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
34.78Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
34.62Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
34.62Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
34.62Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
33.33Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
33.33Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
33.33Single3EMLZM-2413853EML-A2A-ZM-241385
33.33Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
33.33Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
33.33Single4YAYZD-71554YAY-AT1-ZD-7155
33.33Single5IU8Q274563475IU8-A2A-Q27456347-Na
33.33Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
33.33Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
33.33Single5TGZAM65385TGZ-CB1-AM6538
33.33Single5UENDU1725UEN-A1-DU172
33.33Single5UIGCmpd-15UIG-A2A-Cmpd-1
33.33Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
33.33Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
33.33Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
33.33Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
33.33Single6ME5Agomelatine6ME5-MT1-Agomelatine
33.33Single6S0LZM-2413856S0L-A2A-ZM-241385
33.33Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
33.33Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
33.33Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
33.33Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
33.33Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
33.33Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
33.33Single7PYRPSB-21157PYR-A2A-PSB-2115
33.33Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
33.33Single7V3ZCP559407V3Z-CB1-CP55940
33.33Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
33.33Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
33.33Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
33.33Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
33.33Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
33.33Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
33.33Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
33.33Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
33.33Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
33.33Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
33.33Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
33.33Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
33.33Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
33.33Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
33.33Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
33.33Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
33.33Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
33.33Single8K5DGSK2560738K5D-HCA2-GSK256073
33.33Single8RLNLUF58348RLN-A2A-LUF5834
33.33Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
33.33Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
33.33Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
33.33Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
33.33Single8XVJMacitentan8XVJ-ETA-Macitentan
33.33Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
33.33Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
33.33Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
33.33Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
33.33Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
33.33Single9IYAONO-97105319IYA-GPR55-ONO-9710531
33.33Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
33.33Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
33.33Consensusangiotensin_onOrthosteric Ligandat1_on
33.33Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
33.33Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
33.33Consensuscck_onOrthosteric Ligandccka_on cckb_on
33.33Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
33.33Consensuschemerin_onOrthosteric Ligandcml1_on
33.33Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
33.33Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
33.33Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
33.33Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
33.33Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
33.33Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
33.33Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
33.33Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
33.33Consensusprostanoid_offOrthosteric Ligandep_off dp_off
33.33Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
33.33Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
32.14Single6IGLIRL16206IGL-ETB-IRL1620
32.14Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
32.14Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
32.14Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
32.14Consensusbradykinin_onOrthosteric Ligandbk2_on
32.14Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
32.14Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
32.00Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
32.00Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
32.00Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
32.00Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
32.00Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
32.00Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
32.00Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
32.00Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
32.00Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
32.00Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
32.00Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
32.00Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
32.00Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
32.00Consensusvasop-oxy_onOrthosteric Ligandv2_on
32.00Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
31.82Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
31.82Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
31.82Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
31.82Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
31.82Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
31.82Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
31.82Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
31.82Single8QJ2pN1628QJ2-MC4-pN162-Gs
31.82Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
31.82Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
31.82Consensuskisspeptin_onOrthosteric Ligandkiss1_on
31.82Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
31.82Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
31.58Single5IUAQ274563485IUA-A2A-Q27456348-Na
31.58Single5N2RPSB-365N2R-A2A-PSB-36-Na
31.58Single5N2SPSB365N2S-A1-PSB36
31.58Single6D26Fevipiprant6D26-DP2-Fevipiprant
31.58Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
31.58Single6LUQHaloperidol6LUQ-D2-Haloperidol
31.58Single6S0QZM-2413856S0Q-A2A-ZM-241385
31.58Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
31.58Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
31.58Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
31.58Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
31.58Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
31.58Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
31.58Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
31.58Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
31.58Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
31.58Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
31.58Single8GNEKW-63568GNE-A2A-KW-6356-Na
31.58Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
31.58Single8QOTNanobody-E8QOT-μ-Nanobody-E
31.58Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
31.58Single8WGBW9R8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
31.58Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
31.58Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
31.58Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
31.58Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
31.58Consensusdp_offOrthosteric Liganddp2_off
31.58Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
31.58Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
31.58Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
31.58Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
31.58Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
31.58Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
31.58Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
31.58Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
31.58Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
31.25Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
31.25Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
31.25Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
31.25Single3OE9IT1t3OE9-CXCR4-IT1t
31.25Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
31.25Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
31.25Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
31.25Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
31.25Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
31.25Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
31.25Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
31.25Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
31.25Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
31.25Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
31.25Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
31.25Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
31.25Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
31.25Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
31.03Single5GLHEndothelin-15GLH-ETB-Endothelin-1
31.03Single6IGKEndothelin-36IGK-ETB-Endothelin-3
31.03Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
30.77Single5MZPCaffeine5MZP-A2A-Caffeine-Na
30.77Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
30.77Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
30.77Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
30.77Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
30.77Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
30.77Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
30.77Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
30.77Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
30.77Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
30.77Single8ZRTET-18ZRT-ETB-ET-1
30.77Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
30.77Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
30.43Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
30.43Single7QA8Peptide7QA8-STE2-Peptide
30.43Single7QA8Peptide7QA8-STE2-Peptide
30.43Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
30.43Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
30.43Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
30.43Single8IEBA1LYA8IEB-GPR156-A1LYA
30.43Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
30.43Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
30.43Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
30.43Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
30.43Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
30.43Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
30.43Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
30.00Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
30.00Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
30.00Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
30.00Single7FEECP559407FEE-CB1-CP55940-ZCZ011
30.00Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
30.00Single7PX4PSB-21137PX4-A2A-PSB-2113
30.00Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
30.00Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
30.00Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
30.00Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
30.00Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
30.00Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
30.00Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
30.00Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
30.00Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
30.00Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
30.00Single9GE2ML1849GE2-GPR55-ML184-Cholesterol-chim(CtGi1-G13)/β1/γ2
30.00Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
30.00Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
30.00Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
30.00Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
30.00Consensuslpa_onOrthosteric Ligandlpa1_on
30.00Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
30.00Consensusrelaxin_onOrthosteric Ligandrxfp4_on
30.00Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
29.63Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
29.63Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
29.63Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
29.63Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
29.63Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
29.63Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
29.63Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
29.41Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
29.41Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
29.41Single3PWHZM-2413853PWH-A2A-ZM-241385
29.41Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
29.41Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
29.41Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
29.41Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
29.41Single6DS0Ly2660976DS0-5-HT2B-Ly266097
29.41Single6ME9Ramelteon6ME9-MT2-Ramelteon
29.41Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
29.41Single7F8ULintitript7F8U-CCKA-Lintitript
29.41Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
29.41Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
29.41Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
29.41Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
29.41Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
29.41Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
29.41Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
29.41Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
29.41Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
29.41Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
29.41Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
29.41Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
29.41Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
29.41Consensusangiotensin_offOrthosteric Ligandat1_off
29.41Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
29.41Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
29.17Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
29.17Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
29.17Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
29.17Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
29.17Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
29.17Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
29.17Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
29.17Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
29.17Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
29.17Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
29.17Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
29.17Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
29.17Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
29.03Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
28.57Single3PXOAll-trans-Retinal3PXO-Rhodopsin-All-trans-Retinal
28.57Single4N4WSANT-14N4W-SMO-SANT-1
28.57Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
28.57Single5DYSAll-trans-Retinal5DYS-Rhodopsin-All-trans-Retinal
28.57Single6KQICP559406KQI-CB1-CP55940-Org27569
28.57Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
28.57Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
28.57Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Single7K15MKD0467K15-BLT1-MKD046-Na
28.57Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
28.57Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
28.57Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
28.57Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
28.57Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
28.57Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
28.57Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
28.57Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
28.57Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
28.00Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
28.00Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
28.00Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
28.00Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
28.00Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
27.78Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
27.78Single3REYXAC3REY-A2A-XAC
27.78Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
27.78Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
27.78Single5UVIZM-2413855UVI-A2A-ZM-241385
27.78Single6MH8ZM-2413856MH8-A2A-ZM-241385
27.78Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
27.78Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
27.78Single6TPKRetosiban6TPK-OT-Retosiban
27.78Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
27.78Single6ZG9GSK10347026ZG9-M1-GSK1034702
27.78Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
27.78Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
27.78Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
27.78Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
27.78Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
27.78Single8K9LDamgo8K9L-μ-Damgo-VV9-Gi3/β1/γ1
27.78Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
27.78Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
27.78Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
27.78Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
27.78Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
27.78Consensusvasop-oxy_offOrthosteric Ligandot_off
27.59Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
27.59Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
27.59Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
27.27Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
27.27Single6K1QIRL25006K1Q-ETB-IRL2500
27.27Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
27.27Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
27.27Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
27.27Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
27.27Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
27.27Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
27.27Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
27.27Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(CtGi1-G13)/β1/γ2
27.27Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
27.27Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
27.27Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
26.92Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
26.92Single6JODAngiotensin II6JOD-AT2-Angiotensin II
26.92Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
26.92Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
26.92Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
26.92Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
26.92Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
26.92Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
26.92Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
26.92Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
26.92Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
26.92Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
26.92Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
26.67Single3RFMCaffeine3RFM-A2A-Caffeine
26.67Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
26.67Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
26.67Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
26.67Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
26.67Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
26.67Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
26.67Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
26.67Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
26.67Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
26.32Single6GPSMK08126GPS-CCR2-MK0812
26.32Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
26.32Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
26.32Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
26.32Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
26.32Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
26.32Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
26.32Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
26.32Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
26.32Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
26.32Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
26.32Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
26.32Consensusblt_onOrthosteric Ligandblt1_on
26.32Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
26.32Consensuscck_offOrthosteric Ligandccka_off
26.32Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
26.32Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
26.32Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
26.32Consensusleukotriene_onOrthosteric Ligandblt_on
26.32Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
26.09Single5EE7MK08935EE7-Glucagon-MK0893
26.09Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
26.09Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
26.09Single8IEIA1LYA8IEI-GPR156-A1LYA
26.09Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
26.09Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
26.09Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
26.09Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
26.09Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
25.93Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
25.93Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
25.93Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
25.93Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
25.93Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.93Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
25.93Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
25.93Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
25.93Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
25.93Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
25.93Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
25.81Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
25.81Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
25.81Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
25.81Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
25.00Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
25.00Single3OE6IT1t3OE6-CXCR4-IT1t
25.00Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
25.00Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
25.00Single4XT1Fractalkine4XT1-US28-Fractalkine
25.00Single5CGCHTL142425CGC-mGlu5-HTL14242
25.00Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
25.00Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
25.00Single6GPXMK08126GPX-CCR2-MK0812
25.00Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
25.00Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
25.00Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
25.00Single7C4SS1P7C4S-S1P3-S1P
25.00Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
25.00Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
25.00Single7WC5Psilocin7WC5-5-HT2A-Psilocin
25.00Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
25.00Single8IEIA1LYA8IEI-GPR156-A1LYA
25.00Single8IEPA1LYA8IEP-GPR156-A1LYA
25.00Single8IEPA1LYA8IEP-GPR156-A1LYA
25.00Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
25.00Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
25.00Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
25.00Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
25.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
25.00Single8WKYPG-9348WKY-MC4-PG-934
25.00Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
25.00Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
25.00Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
25.00Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
25.00Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
25.00Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
25.00Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
25.00Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
25.00Consensusblt_offOrthosteric Ligandblt1_off
25.00Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
25.00Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
25.00Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
25.00Consensusgi_sensoryOrthosteric Ligandgi_opsins
25.00Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
25.00Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
25.00Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
25.00Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
25.00Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
25.00Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
25.00Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
24.24Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
24.14Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
24.14Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
24.14Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
24.14Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
24.14Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
24.14Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
24.14Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
24.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
24.00Single8IEBA1LYA8IEB-GPR156-A1LYA
24.00Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
24.00Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
24.00Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
24.00Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
24.00Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
24.00Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
23.81Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
23.81Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
23.81Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
23.81Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
23.81Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
23.81Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
23.81Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
23.81Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
23.81Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
23.81Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
23.81Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
23.81Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
23.81Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
23.81Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
23.81Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
23.81Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
23.81Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
23.81Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
23.81Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
23.81Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
23.81Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
23.81Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
23.53Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
23.53Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
23.53Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
23.53Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
23.53Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
23.53Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
23.53Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
23.53Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
23.53Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.53Single9B9Y7DY9B9Y-CB1-7DY
23.53Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
23.33Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
23.33Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
23.33Consensusendothelin_onOrthosteric Ligandetb_on eta_on
23.33Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
23.33Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
23.08Single3OE0CVX153OE0-CXCR4-CVX15
23.08Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
23.08Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
23.08Single6W25SHU91196W25-MC4-SHU9119-Ca
23.08Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
23.08Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
23.08Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
23.08Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
23.08Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
23.08Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
23.08Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
23.08Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
22.86Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
22.86Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
22.73Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
22.73Single5TZYMK8666; PubChem 1270535975TZY-FFA1-MK8666; PubChem 127053597
22.73Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
22.73Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
22.73Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
22.73Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
22.73Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
22.73Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
22.73Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
22.73Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
22.73Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
22.73Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
22.73Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
22.73Single8XJNCloprosetnol8XJN-TP-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
22.22Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
22.22Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
22.22Single3ODUIT1t3ODU-CXCR4-IT1t
22.22Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
22.22Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
22.22Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
22.22Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
22.22Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
22.22Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
22.22Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
22.22Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
22.22Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
22.22Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
22.22Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
22.22Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
22.22Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
22.22Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
22.22Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
22.22Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
22.22Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.22Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
22.22Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.22Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
22.22Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
22.22Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
22.22Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
22.22Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
22.22Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
21.88Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
21.88Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
21.88Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
21.74Single5CGDHTL142425CGD-mGlu5-HTL14242
21.74Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
21.74Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
21.74Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
21.74Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
21.74Consensustp_onOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Consensustp_on_gpOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Single4A4MAll-trans-Retinal4A4M-Rhodopsin-All-trans-Retinal-Gt(CT)
21.43Single5EN0All-trans-Retinal5EN0-Rhodopsin-All-trans-Retinal-Gt(CT)
21.43Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
21.43Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
21.43Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
21.43Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
21.43Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
21.43Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
21.43Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
21.43Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
21.05Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
21.05Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
21.05Single7VODCariprazine7VOD-5-HT2A-Cariprazine
21.05Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
21.05Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
21.05Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
21.05Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
21.05Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
21.05Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Cholesterol-Gi1/β1/γ2
21.05Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
21.05Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
20.83Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
20.83Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
20.83Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
20.83Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
20.83Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
20.83Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
20.83Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
20.83Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
20.83Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
20.83Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
20.69Single4XT3Fractalkine4XT3-US28-Fractalkine
20.69Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
20.69Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
20.69Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
20.69Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
20.69Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
20.69Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
20.69Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
20.59Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
20.59Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
20.00Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
20.00Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
20.00Single6D27CAY104716D27-DP2-CAY10471
20.00Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
20.00Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
20.00Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
20.00Single6IIVDaltroban6IIV-TP-Daltroban
20.00Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
20.00Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
20.00Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
20.00Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
20.00Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
20.00Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
20.00Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
20.00Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
20.00Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single7WC4Serotonin7WC4-5-HT2A-Serotonin
20.00Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
20.00Single7YXAONO-54306087YXA-S1P5-ONO-5430608
20.00Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
20.00Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
20.00Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
20.00Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
20.00Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/β1/γ2
20.00Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
20.00Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
20.00Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
20.00Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
20.00Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
20.00Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
20.00Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
19.51Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
19.35Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
19.35Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
19.35Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
19.35Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
19.35Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
19.35Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
19.35Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
19.35Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
19.35Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
19.35Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
19.35Single8IY6Endothelin-18IY6-ETB-Endothelin-1
19.35Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
19.23Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
19.23Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
19.23Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
19.23Single7XNACYN1548067XNA-SST2-CYN154806
19.23Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
19.23Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
19.23Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
19.23Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
19.23Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
19.23Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
19.23Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
19.23Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
19.05Single4NTJAZD12834NTJ-P2Y12-AZD1283
19.05Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
19.05Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
19.05Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
19.05Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
19.05Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
19.05Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
19.05Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
19.05Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
19.05Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
19.05Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
19.05Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
19.05Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
19.05Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
19.05Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
19.05Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
19.05Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
19.05Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
19.05Consensusep_offOrthosteric Ligandep4_off
18.75Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
18.75Single3OE8IT1t3OE8-CXCR4-IT1t
18.75Single6TQ9SB-4081246TQ9-OX1-SB-408124
18.75Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
18.75Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
18.52Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
18.52Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.52Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
18.52Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
18.52Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
18.52Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
18.52Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
18.52Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
18.52Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
18.18Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
18.18Single5TZRMK86665TZR-FFA1-MK8666
18.18Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
18.18Single7P2L4YI7P2L-mGlu5-4YI
18.18Single7R0CAVP7R0C-V2-AVP-Arrestin2
18.18Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
18.18Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
18.18Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
18.18Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
18.18Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
18.18Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
18.18Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
18.18Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
18.18Single9BJKNAM9BJK-μ-Naloxone-NAM
18.18Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
18.18Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
17.86Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
17.86Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
17.86Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
17.86Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
17.86Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
17.86Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
17.86Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ22
17.86Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
17.86Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
17.86Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
17.65Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
17.65Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
17.65Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.65Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
17.65Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
17.65Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
17.39Single4PY02MeSATP4PY0-P2Y12-2MeSATP
17.39Single4XEENeurotensin4XEE-NTS1-Neurotensin
17.39Single4XESNeurotensin4XES-NTS1-Neurotensin
17.39Single5X33BIIL2605X33-BLT1-BIIL260
17.39Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
17.39Single6IIURamatroban6IIU-TP-Ramatroban
17.39Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
17.39Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
17.39Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
17.39Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
17.39Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
17.39Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
17.39Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
17.39Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
17.24Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
17.24Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
17.24Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
17.14Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
16.67Single4BUONeurotensin4BUO-NTS1-Neurotensin
16.67Single5L7IVismodegib5L7I-SMO-Vismodegib
16.67Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
16.67Single6FJ3PTH6FJ3-PTH1-PTH
16.67Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
16.67Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
16.67Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
16.67Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
16.67Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
16.67Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
16.67Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
16.67Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
16.67Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
16.67Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
16.67Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
16.67Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
16.67Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
16.67Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
16.67Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
16.67Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
16.67Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
16.67Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
16.67Consensusgq_nucleotideOrthosteric Ligandgq_p2y
16.67Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
16.13Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
16.13Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
16.13Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
16.13Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
16.13Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
16.13Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
16.13Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
16.13Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
16.00Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
16.00Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
16.00Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.00Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
16.00Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79Single5U09Taranabant5U09-CB1-Taranabant
15.79Single5ZKQABT-4915ZKQ-PAF-ABT-491
15.79Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
15.79Single7BR3Elagolix7BR3-GnRH1-Elagolix
15.79Single7F8YDevazepide7F8Y-CCKA-Devazepide
15.79Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
15.79Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
15.79Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
15.79Single9BA0A1AKN9BA0-CB1-A1AKN
15.79Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
15.79Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
15.79Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
15.62Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
15.62Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
15.38Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
15.38Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
15.38Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
15.38Single8KIGSHU91198KIG-MC3-SHU9119-Ca
15.38Consensussomatostatin_offOrthosteric Ligandsst2_off
15.15Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
15.00Single6FFIMMPEP6FFI-mGlu5-MMPEP
15.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
15.00Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
15.00Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
15.00Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
15.00Single8K2WAMG4878K2W-CXCR3-AMG487
15.00Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
15.00Single8ZPMAMD0708ZPM-CXCR4-AMD070-Cholesterol
15.00Single8ZPNAMD31008ZPN-CXCR4-AMD3100-Cholesterol
15.00Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
15.00Consensusgrh_offOrthosteric Ligandgnrh1_off
14.81Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
14.81Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
14.81Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
14.81Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
14.71Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
14.71Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
14.29Single4QIMANTA XV4QIM-SMO-ANTA XV
14.29Single6FFHFenobam6FFH-mGlu5-Fenobam
14.29Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
14.29Single7F83PF-051904577F83-Ghrelin-PF-05190457
14.29Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
14.29Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
14.29Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
14.29Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
14.29Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
14.29Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
14.29Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
14.29Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
14.29Single9B9ZA1AKO9B9Z-CB1-A1AKO
14.29Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
14.29Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
14.29Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
14.29Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
13.89Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
13.89Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
13.79Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
13.79Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
13.64Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
13.64Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
13.64Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
13.33Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
13.33Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
13.33Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
13.33Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
13.33Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
13.33Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
13.33Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
13.04Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
13.04Single4BV0Neurotensin4BV0-NTS1-Neurotensin
13.04Single5V56TC1145V56-SMO-TC114
13.04Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
13.04Single7F1TMIP-1a7F1T-CCR5-MIP-1a
13.04Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
13.04Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
13.04Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.04Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.04Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.04Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
13.04Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
13.04Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
13.04Consensusneurotensin_onOrthosteric Ligandnts1_on
13.04Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
13.04Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
12.90Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
12.90Single7SK3CXCL127SK3-ACKR3-CXCL12
12.90Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
12.50Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
12.50Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
12.50Single6OS2TRV0266OS2-AT1-TRV026
12.50Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
12.50Single6YVRNTS8-136YVR-NTS1-NTS8-13
12.50Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
12.50Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
12.50Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
12.50Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
12.50Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
12.50Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
12.50Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
12.50Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
12.50Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
12.50Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
12.50Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
12.50Single8ZPLHF511168ZPL-CXCR4-HF51116-Cholesterol
12.50Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
12.50Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
12.50Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
12.50Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
12.50Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
12.50Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
12.50Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
12.12Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
12.12Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
12.00Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
12.00Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
12.00Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
12.00Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
12.00Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-PubChem 118610427-chim(NtGi1-Go)/β1/γ2
12.00Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
12.00Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
12.00Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.00Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.76Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/β1/γ2
11.76Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
11.54Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
11.54Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
11.54Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
11.54Single8XQJJN2418XQJ-Apelin-JN241
11.54Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
11.54Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
11.54Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
11.43Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
11.43Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
11.11Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
11.11Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
11.11Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
11.11Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
11.11Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/β1/γ2
11.11Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.11Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
11.11Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
11.11Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
11.11Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
10.81Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
10.71Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
10.71Single7SK5CXCL127SK5-ACKR3-CXCL12
10.71Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
10.71Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
10.53Single6LI0C176LI0-GPR52-C17
10.53Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
10.53Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.53Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
10.53Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
10.53Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
10.53Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
10.53Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
10.34Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
10.34Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
10.34Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
10.00Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
10.00Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
10.00Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
10.00Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.00Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
10.00Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
10.00Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
10.00Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.00Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.00Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/β1/γ2
10.00Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
9.68Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
9.52Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
9.52Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
9.52Single6ZINSR486926ZIN-NTS1-SR48692
9.52Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
9.52Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
9.52Single7VV6C48/807VV6-MRGPRX2-C48/80
9.52Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
9.52Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
9.09Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
9.09Single5T04Neurotensin5T04-NTS1-Neurotensin
9.09Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
9.09Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
9.09Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
9.09Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
9.09Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
9.09Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
9.09Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
9.09Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
9.09Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
9.09Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
9.09Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
8.70Single4JKVTaladegib4JKV-SMO-Taladegib
8.70Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
8.70Single6Z4SSR486926Z4S-NTS1-SR48692
8.70Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
8.70Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
8.70Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
8.70Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
8.33Single5V57TC1145V57-SMO-TC114
8.33Single6OS1TRV0266OS1-AT1-TRV026
8.33Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Cholesterol-Gi1/β1/γ1
8.00Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
8.00Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
8.00Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.00Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.00Single8XQJJN2418XQJ-Apelin-JN241
8.00Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
7.89Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
7.69Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
7.69Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
7.69Single8XVUCXCL28XVU-CXCR2-CXCL2
7.69Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
7.41Single6KNMJN241-96KNM-Apelin-JN241-9
7.41Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
7.41Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
7.41Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
7.14Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
7.14Single8XWNCXCL88XWN-CXCR2-CXCL8
6.90Single7SHEPI; PE7SHE-GPR158-PI; PE
6.67Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
6.25Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/β1/γ2
5.88Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
5.88Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
5.56Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
5.56Single7Y14Beta-Alanine7Y14-MRGPRD-β-Alanine
5.56Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/β1/γ2
5.56Consensusp2y_offOrthosteric Ligandp2y1_off
5.26Single4XNWMRS25004XNW-P2Y1-MRS2500
5.26Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
5.26Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
5.26Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
5.26Single7Y12Beta-Alanine7Y12-MRGPRD-β-Alanine-Gi1/β1/γ2
5.26Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
5.26Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
5.00Single4O9RCyclopamine4O9R-SMO-Cyclopamine
5.00Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
5.00Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
5.00Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
5.00Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
5.00Single8YRGFospropofol8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Single4BWBNeurotensin4BWB-NTS1-Neurotensin
4.76Single4QINSAG1.54QIN-SMO-SAG1.5
4.76Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
4.76Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
4.76Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
4.76Single7VVOPTH7VVO-PTH1-PTH-Gs/β1/γ2
4.76Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
4.76Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
4.76Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
4.76Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
4.76Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
4.55Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
4.55Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
4.55Single8IYXYL-3658IYX-GPR34-YL-365
4.55Single8JD6N-(3-chlorophenyl)pyridine-2-carboxamide8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
4.35Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/β1/γ2
4.35Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
4.35Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
4.35Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
4.35Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
4.17Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
4.17Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
4.00Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
4.00Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
4.00Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
3.85Single7SHEPI; PE7SHE-GPR158-PI; PE
3.85Single8XWACXCL18XWA-CXCR2-CXCL1
3.85Single8XWMCXCL68XWM-CXCR2-CXCL6
3.85Single8XWSCXCL58XWS-CXCR2-CXCL5
3.85Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
3.70Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
3.70Single8XWFCXCL38XWF-CXCR2-CXCL3
3.70Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
3.57Single5TZYMK8666; PubChem 1270535975TZY-FFA1-MK8666; PubChem 127053597
3.45Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
3.45Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
3.45Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
3.33Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7

Consensus Members
Id Members
7F0T 7F0T-D1-Dopamine-Gs/β1/γ2
7CKY 7CKY-D1-PW0464-Gs/β1/γ2
8IRR 8IRR-D1-Rotigotine-Gs/β1/γ2
7JV5 7JV5-D1-SKF81297-Gs/β1/γ2
7JVP 7JVP-D1-SKF83959-Gs/β1/γ2
7X2D 7X2D-D1-Tavapadon-Gs/β1/γ2
7CKX 7CKX-D1-A77636-Gs/β1/γ2
7JVQ 7JVQ-D1-Apomorphine-Gs/β1/γ2
7CKW 7CKW-D1-Fenoldopam-Gs/β1/γ2
Net Summary
Imin 3.34111
Number of Linked Nodes 928
Number of Links 1106
Number of Hubs 170
Number of Links mediated by Hubs 661
Number of Communities 24
Number of Nodes involved in Communities 224
Number of Links involved in Communities 327
Path Summary
Number Of Nodes in MetaPath 128
Number Of Links MetaPath 127
Number of Shortest Paths 20419461
Length Of Smallest Path 3
Average Path Length 71.6785
Length of Longest Path 82
Minimum Path Strength 0.235556
Average Path Strength 8.00057
Maximum Path Strength 21.64
Minimum Path Correlation 0.706667
Average Path Correlation 1
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.40845
Average % Of Corr. Nodes 26.2385
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 64.2057
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following consensuses:
IdComponents
dopamine_on_gpd2_on_gp
d1_on_gp
d3_on_gp
d4_on_gp
d5_on_gp



You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download d1_on_gp.zip



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