Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
1Lig 19.17833010
2NT 7.60861614
31x39 5.813507
41x50 6.52333409
52x42 4.15792407
62x46 5.693519
72x50 5.522519
82x53 3.54417407
92x57 6.77167607
10E1x50 7.51083618
11E1x52 8.405407
123x34 3.45405
133x43 4.03708418
143x49 4.8975408
153x55 5.34708447
16I2 7.401525
174x61 4.75415
18E2 20.73391613
19E2x52 7.62125414
205x36 7.8675414
215x39 5.92417416
225x47 6.61333408
235x58 5.23917619
246x26 3.90786704
256x30 2.51625407
266x44 4.4419
276x48 4.83194618
286x54 4.49933514
29E3 6.04643713
307x38 7.315415
317x52 3.97625408
327x53 4.65139619
338x50 3.76111938
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
11x32 2x65 11.49773.13833NoNo044
22x61 2x65 14.67923.23833NoNo064
31x39 2x61 16.25246.61YesNo076
41x39 7x38 23.79674.35667YesYes075
57x38 Lig 37.17187.61YesYes150
61x39 2x57 29.26494.85167YesYes077
72x57 7x42 17.743710.7483YesNo077
87x38 7x42 13.91896.56833YesNo057
91x42 2x57 12.48617.39333NoYes077
101x50 2x51 12.39253.49667YesNo097
111x50 2x50 45.52318.75167YesYes099
122x46 2x50 46.61093.62YesYes199
132x46 3x43 19.14734.845YesYes198
143x43 6x44 1003.045YesYes189
156x44 6x48 79.05146.51333YesYes198
163x36 6x48 90.08135.20833NoYes178
173x36 Lig 84.96994.32NoYes170
182x50 7x49 11.38086.73YesNo199
193x43 7x49 12.36914.34833YesNo189
202x50 7x46 43.04934.33667YesNo099
212x54 7x46 42.96746.64NoNo069
222x54 2x57 43.0614.725NoYes067
231x50 2x47 18.52164.07YesNo099
241x50 7x50 12.39259.775YesNo099
251x54 2x47 12.39253.14NoNo079
262x43 8x50 43.31832.61833NoYes088
272x43 7x53 44.64593.63NoYes089
283x43 7x53 70.34913.91YesYes189
291x56 8x50 21.38723.02333NoYes078
301x56 8x53 12.22883.885NoNo076
312x42 3x49 61.05045.52667YesYes078
322x42 3x46 68.89293.525YesNo079
333x46 7x53 65.95123.66333NoYes199
342x42 3x45 12.62654.00667YesNo077
352x45 3x42 13.54473.45667NoNo098
362x46 3x42 14.42196.97333YesNo098
372x45 4x50 13.23474.89667NoNo099
383x32 Lig 11.67910.685NoYes160
393x28 3x32 10.45095.83333NoNo056
40E2 Lig 32.914255.9317YesYes130
413x50 5x58 11.43344.28667NoYes199
426x40 7x53 23.0547.11667NoYes089
433x49 3x53 53.12013.17YesNo088
443x55 3x56 44.60495.93YesNo077
453x52 3x56 45.85064.4NoNo047
463x52 I2 47.07885.39167NoYes245
473x53 I2 51.93874.17833NoYes285
486x26 6x30 16.87234.26833YesYes047
495x68 6x26 33.21253.29333NoYes064
505x64 5x68 34.59852.23333NoNo056
513x55 5x64 37.05483.68167YesNo075
525x47 5x48 15.78452.93YesNo084
535x47 6x52 10.181910.2367YesNo087
546x48 6x52 11.74343.35YesNo087
555x51 6x44 18.76724.66833NoYes059
566x40 7x52 13.94236.185NoYes088
572x46 7x53 36.37644.10333YesYes199
585x47 5x51 15.62084.3YesNo085
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
E2Lig55.93171YesYes3010
E2x51Lig6.418331NoYes4010
LigNT20.81171YesYes0401
7x28Lig5.681670NoYes3010
E3Lig13.14171YesYes3010
7x31Lig10.82330NoYes4010
7x30Lig9.078331NoYes4010
2x63Lig20.2251NoYes5010
E2x52Lig7.531YesYes4010
6x55Lig15.07171NoYes5010
6x58Lig20.26170NoYes4010
6x59Lig6.553331NoYes5010
2x60Lig13.51331NoYes6010
7x34Lig15.64331NoYes4010
4x61Lig4.128331YesYes5010
5x39Lig3.416671YesYes6010
5x40Lig7.576671NoYes4010
3x32Lig10.6851NoYes6010
3x33Lig3.233331NoYes4010
3x36Lig4.321NoYes7010
5x43Lig5.493331NoYes5010
5x461Lig7.891NoYes6010
7x38Lig7.611YesYes5010
7x29NT3.113331NoYes3421
1x397x384.356670YesYes7521
2x532x564.523330YesNo7622
2x537x423.420YesNo7722
2x563x325.596670NoNo6621
2x607x3810.7251NoYes6511
2x63E1x5012.05671NoYes5812
2x63E23.831671NoYes5311
E1x49E24.093331NoYes5321
3x25E1x506.748331NoYes9822
3x28E1x503.758330NoYes5822
E1x50E23.138331YesYes8321
E1x50E2x503.2651YesNo8922
3x22E28.008331NoYes3321
3x25E2x507.281NoNo9922
3x283x325.833330NoNo5621
3x334x615.408331NoYes4511
3x366x485.208331NoYes7812
3x375x4614.358330NoNo6621
4x605x399.968330NoYes8621
4x615x396.228331YesYes5611
4x64E212.86671NoYes5321
4x65E2x526.313330NoYes6421
E2E297.26671YesYes3311
E2E2x517.876671YesNo3411
E2E2x505.481671YesNo3912
E2E2x528.7851YesYes3411
5x36E211.52331YesYes4311
5x39E24.083331YesYes6311
5x406x598.711NoNo4511
5x435x4616.766671NoNo5611
6x516x555.020NoNo6521
6x54E33.053331YesYes4311
6x547x303.951YesNo4411
6x547x333.5351YesNo4512
6x547x348.751671YesNo4411
6x61E36.281NoYes2321
7x30E34.346671NoYes4311
7x387x426.568331YesNo5712
NTNT7.808331YesYes4411
3x25E25.018331NoYes9321
4x614x653.2351YesNo5612
5x366x596.233331YesNo4511
6x57E33.050NoYes5321
E2NT5.383331YesYes3411
2x533x363.056670YesNo7721
2x67Lig8.370NoYes5010
5x36E2x527.856671YesYes4411
5x36Lig5.856671YesYes4010
6x54Lig3.206671YesYes4010
E3E36.226671YesYes3311
7x27Lig5.860NoYes1010
7x26Lig1.470NoYes1010
5x435x461.383331NoNo5412
5x35E21.186671NoYes3321
1x27NT0.7266670NoYes3421

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
93.10Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
86.67Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
80.65Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
73.33Single7VGXNeuropeptide Y7VGX-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
70.00Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
68.97Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
68.97Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
66.67Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
66.67Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
60.00Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
53.12Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
52.94Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
52.94Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
52.94Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
51.61Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
51.52Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
51.52Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
51.43Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
50.00Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
50.00Consensusgi_somatostatinOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
50.00Consensusnmur2_onOrthosteric Ligand7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
50.00Consensussst2_onOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
48.57Single8FEGPRD_0025178FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
48.48Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
48.48Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
48.48Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
48.48Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
48.39Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
48.28Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
46.88Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1
46.88Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
46.67Single7XN9L-054,5227XN9-SST2-L-054,522
46.67Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
46.67Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
45.45Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
45.45Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
45.16Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
45.16Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
45.16Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
44.83Single7Y24Octreotide7Y24-SST2-Octreotide-Go/&β;1/&γ;2
44.44Single8IY6Endothelin-18IY6-ETB-Endothelin-1
44.44Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
44.44Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
44.12Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
44.12Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
43.75Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
43.75Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
43.75Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
43.33Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
43.33Consensuscckb_onOrthosteric Ligand7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
43.33Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
43.33Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
43.24Single6IGKEndothelin-36IGK-ETB-Endothelin-3
42.86Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
42.86Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
42.42Single3OE0CVX153OE0-CXCR4-CVX15
42.42Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
42.42Consensusangiotensin_onOrthosteric Ligandat1_on
42.42Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
42.42Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
42.42Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
42.42Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
42.11Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
41.94Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
41.94Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
41.94Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2 8I95-C3aB-EP54-Go/&β;1/&γ;2
41.94Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
41.94Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
41.67Consensusendothelin_onOrthosteric Ligandetb_on eta_on
41.67Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
41.38Consensuscck_onOrthosteric Ligandccka_on cckb_on
41.18Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
41.18Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
41.18Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
41.18Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
41.18Consensusnmur_onOrthosteric Ligandnmur1_on nmur2_on
40.62Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
40.62Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
40.62Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
40.62Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
40.62Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
40.62Consensusmop_offOrthosteric Ligand7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
40.62Consensussst_onOrthosteric Ligandsst2_on sst4_on
40.54Single6IGLIRL16206IGL-ETB-IRL1620
40.00Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
40.00Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
40.00Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
40.00Single7KH0Acyclovir triphosphate7KH0-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
40.00Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
40.00Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
40.00Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
40.00Single7Y66BM2137Y66-C5a1-BM213-Gi1/&β;1/&γ;2
40.00Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
40.00Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
40.00Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
40.00Consensusgs_neuromedinOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
39.47Single5GLHEndothelin-15GLH-ETB-Endothelin-1
39.39Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
39.39Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
39.39Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
38.89Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
38.89Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
38.89Consensusgi_neuromedinOrthosteric Ligand7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
38.89Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
38.89Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
38.71Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2
38.71Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
38.71Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
38.71Consensusgs_orexinOrthosteric Ligand7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
38.71Consensusorexin_onOrthosteric Ligandox2_on
38.46Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
38.24Single6PT2KGCHM076PT2-δ-KGCHM07
38.24Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
37.93Single7CFNINT-7777CFN-GPBA-INT-777-Gs/&β;1/&γ;2
37.93Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
37.93Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
37.93Consensusgs_sstOrthosteric Ligand7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
37.84Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
37.84Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
37.50Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
37.50Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
37.50Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
37.50Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
37.50Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
37.50Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
37.50Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
37.50Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
37.50Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
37.50Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
37.14Single6JODAngiotensin II6JOD-AT2-Angiotensin II
37.14Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
37.14Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
37.14Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
37.14Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
37.14Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
36.84Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
36.84Consensusgs_endothelinOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
36.67Single7XOWGastrin7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
36.67Single7XOXCholecystokinin-87XOX-CCKB-Cholecystokinin-8-Gq/&β;1/&γ;2
36.67Single8FMZNeurotensin/neuromedin N8FMZ-NTS1-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
36.67Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
36.67Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
36.67Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
36.67Consensusnpy_offOrthosteric Ligandnpy2_off npy1_off
36.59Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
36.36Single4IARErgotamine4IAR-5-HT1B-Ergotamine
36.36Single7F8XNN90567F8X-CCKA-NN9056
36.36Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
36.36Single8G59TUG-8918G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
36.36Consensusfpr-alx_onOrthosteric Ligandfpr1-alx_on fpr2-alx_on
36.36Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
36.36Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
36.11Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
35.48Single6MXTSalmeterol6MXT-β2-Salmeterol
35.48Single6OS2TRV0266OS2-AT1-TRV026
35.48Single8I95EP548I95-C3aB-EP54-Go/&β;1/&γ;2
35.48Single8J6DEP1418J6D-C3aB-EP141-Go/&β;1/&γ;2
35.48Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
35.48Consensusdp_offOrthosteric Liganddp2_off
35.29Single3QAKUK-4320973QAK-A2A-UK-432097
35.29Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
35.29Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
35.29Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
35.29Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
35.29Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
35.29Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
35.29Consensusalpha1_offOrthosteric Ligandalpha1a_off alpha1b_off
35.29Consensuscx3cr_onOrthosteric Ligandcx3cr1_on
35.29Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
35.29Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
35.14Single7SK3CXCL127SK3-ACKR3-CXCL12
35.14Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
35.14Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
35.14Consensusbb1_onOrthosteric Ligand8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
35.14Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
35.00Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
34.38Single4BUONeurotensin4BUO-NTS1-Neurotensin
34.38Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
34.38Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
34.38Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
34.38Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
34.38Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
34.38Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
34.38Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
34.38Single8ID8TUG-8918ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
34.38Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
34.38Consensusgi_neurotensinOrthosteric Ligand7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
34.38Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
34.29Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
34.29Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
34.29Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
34.29Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
34.29Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;2
34.29Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
34.29Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
34.29Consensuscx3cr1_onOrthosteric Ligand7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
34.29Consensusgi_chemerinOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
34.29Consensusgi_formylpeptideOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
34.29Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
34.21Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
34.21Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
34.21Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
34.21Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
34.21Consensusetb_onOrthosteric Ligand8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
34.15Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
33.33Single3NY9PubChem 9131033NY9-β2-PubChem 913103
33.33Single5N2SPSB365N2S-A1-PSB36
33.33Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
33.33Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
33.33Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
33.33Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
33.33Single7C61Ergotamine7C61-5-HT1B-Ergotamine
33.33Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
33.33Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
33.33Single7XY6PubChem 117178317XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
33.33Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
33.33Single8JPCNeurotensin 8-138JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
33.33Single8QOTNanobody E8QOT-μ-Nanobody E
33.33Consensusfpr2-alx_onOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
33.33Consensusgo_vasopressinOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
33.33Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
32.50Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
32.50Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
32.43Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
32.43Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
32.43Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
32.43Consensusgs_bradykininOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
32.43Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
32.35Single4AMJ(S)-Carvedilol4AMJ-β1-(S)-Carvedilol
32.35Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
32.35Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
32.35Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
32.35Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
32.35Consensusnmur1_onOrthosteric Ligand7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
32.26Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
32.26Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
32.26Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
32.26Single6OS1TRV0266OS1-AT1-TRV026
32.26Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
32.26Single7JVPSKF839597JVP-D1-SKF83959-Gs/&β;1/&γ;2
32.26Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
32.26Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2
32.26Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
32.26Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
32.26Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
32.26Consensus5ht5_offOrthosteric Ligand5ht5a_off
32.26Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
32.26Consensuschemerin_onOrthosteric Ligandcml1_on
32.26Consensuscml1_onOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
32.26Consensusffa4_onOrthosteric Ligand8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
32.26Consensusgi_dopamineOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
32.26Consensusgs_compl-peptideOrthosteric Ligand8I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
32.26Consensusnk1_offOrthosteric Ligand6J20-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
32.26Consensusrelaxin_onOrthosteric Ligandrxfp4_on
32.14Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
31.71Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
31.58Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
31.43Single6HLOAprepitant6HLO-NK1-Aprepitant
31.43Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
31.43Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
31.43Single7SK5CXCL127SK5-ACKR3-CXCL12
31.43Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
31.43Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.43Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
31.25Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
31.25Single4XEENeurotensin4XEE-NTS1-Neurotensin
31.25Single4XESNeurotensin4XES-NTS1-Neurotensin
31.25Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
31.25Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
31.25Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/&β;1/&γ;2
31.25Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/&β;1/&γ;2
31.25Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.25Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
31.25Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
31.25Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
31.25Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2
31.25Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2
31.25Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.25Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
31.25Single8JJLOlodaterol8JJL-β2-Olodaterol
31.25Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/&β;1/&γ;2
31.25Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
31.25Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
31.25Consensusgs_bileacidOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
31.25Consensusgs_steroidOrthosteric Ligandgs_bileacid
31.25Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
31.25Consensusnts1_offOrthosteric Ligand6Z4Q-NTS1-SR142948A 6Z4S-NTS1-SR48692
31.25Consensusnts1_onOrthosteric Ligand6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
31.25Consensusnts_offOrthosteric Ligandnts1_off
31.25Consensusnts_onOrthosteric Ligandnts1_on
31.25Consensuspeptide_offOrthosteric Ligandopioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
31.25Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
31.03Single7XOVSR1461317XOV-CCKA-SR146131-Gs/&β;1/&γ;2
31.03Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
31.03Consensuscxcr_onOrthosteric Ligandcxcr1_on cxcr2_on
31.03Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
30.77Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
30.56Single5WF5UK-4320975WF5-A2A-UK-432097
30.56Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
30.56Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
30.56Single7XNACYN1548067XNA-SST2-CYN154806
30.56Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
30.56Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
30.56Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.56Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
30.30Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
30.30Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
30.30Single6IBLArformoterol6IBL-β1-Arformoterol
30.30Single7EZCUKA7EZC-A2A-UKA
30.30Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
30.30Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
30.30Single7UM4AS26747237UM4-5-HT5A-AS2674723
30.30Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
30.30Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
30.30Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.30Single8WRZ8D08WRZ-CB1-8D0-Arrestin1
30.30Consensus5ht5a_offOrthosteric Ligand7UM4-5-HT5A-AS2674723
30.30Consensusbeta1_off_alloOrthosteric Ligand4BVN-β1-Cyanopindolol-Na
30.30Consensusbileacid_onOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
30.30Consensusc5a1_off_ortoalloOrthosteric Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
30.30Consensusffa4_on_alloOrthosteric Ligand8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.30Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.30Consensusgs_galaninOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.30Consensusot_onOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
30.30Consensussteroid_onOrthosteric Ligandbileacid_on
30.00Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
30.00Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
30.00Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/&β;1/&γ;2
30.00Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
30.00Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
30.00Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
30.00Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
29.73Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
29.73Single8IHFMK68928IHF-HCA2-MK6892-Gi1/&β;1/&γ;2
29.73Single8J6IMK68928J6I-HCA2-MK6892-Gi1/&β;1/&γ;2
29.41Single4UG2CGS216804UG2-A2A-CGS21680
29.41Single5WF6UK-4320975WF6-A2A-UK-432097
29.41Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
29.41Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
29.41Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
29.41Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
29.41Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
29.41Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
29.41Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
29.41Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
29.41Consensusgs_bombesinOrthosteric Ligand8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.17Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
29.03Single5C1MBU725C1M-μ-BU72
29.03Single6D26Fevipiprant6D26-DP2-Fevipiprant
29.03Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
29.03Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
29.03Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
29.03Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
29.03Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
29.03Single7CKXA776367CKX-D1-A77636-Gs/&β;1/&γ;2
29.03Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
29.03Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
29.03Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
29.03Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
29.03Single7XKAEpinephrine7XKA-β2-Epinephrine
29.03Single8GNEKW-63568GNE-A2A-KW-6356-Na
29.03Single8ID9Eicosapentaenoic acid8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
29.03Single8UNYEpinephrine8UNY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
29.03Consensusa1_on_alloOrthosteric Ligand7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
29.03Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRR-D1-Rotigotine-Gs/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
29.03Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
29.03Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
28.95Consensusbk1_onOrthosteric Ligand7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.95Consensusbombesin_onOrthosteric Ligandbb2_on bb1_on
28.95Consensusgs_melanocortinOrthosteric Ligand7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2
28.57Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
28.57Single4XT1Fractalkine4XT1-US28-Fractalkine
28.57Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
28.57Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
28.57Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
28.57Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
28.57Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
28.57Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
28.57Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.57Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
28.57Single8GH1Epinephrine8GH1-β2-Epinephrine
28.57Single8GHVPubChem 1459649038GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
28.57Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
28.57Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
28.21Single4XT3Fractalkine4XT3-US28-Fractalkine
28.21Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
28.21Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
28.12Single3P0GBI1671073P0G-β2-BI167107
28.12Single3SN6BI1671073SN6-β2-BI167107-Gs/&β;1/&γ;2
28.12Single4BV0Neurotensin4BV0-NTS1-Neurotensin
28.12Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
28.12Single4RWADIPP-NH24RWA-δ-DIPP-NH2
28.12Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
28.12Single5D5A(S)-Carazolol5D5A-β2-(S)-Carazolol
28.12Single5D5B(S)-Carazolol5D5B-β2-(S)-Carazolol
28.12Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
28.12Single6J20Aprepitant6J20-NK1-Aprepitant
28.12Single6J21Aprepitant6J21-NK1-Aprepitant
28.12Single6NI3BI1671076NI3-β2-BI167107-Gs/&β;1/&γ;2
28.12Single6WGTLSD6WGT-5-HT2A-LSD
28.12Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
28.12Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
28.12Single7JV5SKF812977JV5-D1-SKF81297-Gs/&β;1/&γ;2
28.12Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1
28.12Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/&β;1/&γ;1
28.12Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
28.12Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
28.12Single7TUYGSK682753A7TUY-GPR183-GSK682753A
28.12Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
28.12Single7XTQR3997XTQ-GPBA-R399-Gs/&β;1/&γ;2
28.12Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/&β;1/&γ;2
28.12Single8E0GBU728E0G-μ-BU72
28.12Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2
28.12Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
28.12Consensus5ht1b_onOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
28.12Consensusa2_onOrthosteric Liganda2a_on a2b_on
28.12Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCZ-β1-Iodocyanopindolol
28.12Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
28.12Consensuscyslt1_off_ortoalloOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
28.12Consensusgi_ffaOrthosteric Ligand8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
28.12Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2
27.78Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
27.78Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
27.78Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
27.78Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
27.78Consensussst_offOrthosteric Ligandsst2_off
27.59Single7F8YDevazepide7F8Y-CCKA-Devazepide
27.59Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
27.59Single8GNGIstradefylline8GNG-A2A-Istradefylline
27.59Consensusm2_on_alloOther Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
27.59Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
27.50Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
27.27Single3D4STimolol Maleate3D4S-β2-Timolol Maleate
27.27Single4AMIBucindolol4AMI-β1-Bucindolol
27.27Single4GRVNeurotensin 8-134GRV-NTS1-Neurotensin 8-13
27.27Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
27.27Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
27.27Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
27.27Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
27.27Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
27.27Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
27.27Single6YVRNTS8-136YVR-NTS1-NTS8-13
27.27Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
27.27Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.27Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
27.27Single7YITNalfurafine7YIT-κ-Nalfurafine
27.27Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
27.27Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.27Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2
27.27Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
27.27Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
27.27Single8JJ8Formoterol8JJ8-β2-Formoterol
27.27Single8JPBNeurotensin 8-138JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
27.27Single8WU1KCA8WU1-CB1-KCA-Arrestin1
27.27Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
27.27Consensuscannabinoid_onOrthosteric Ligandcb1_on cb2_on
27.27Consensuscb1_onOrthosteric Ligand8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
27.27Consensuschemokine_offOrthosteric Ligandcxcr_off
27.27Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
27.27Consensuscxcr_offOrthosteric Ligandcxcr4_off
27.27Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
27.27Consensusgi_cannabinoidOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
27.27Consensusgo_5htOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
27.27Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
27.27Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
27.27Consensusopioid_offOrthosteric Ligandkop_off mop_off nop_off dop_off
27.03Single7F4DAlpha-MSH7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
26.83Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
26.67Single4MBSMaraviroc4MBS-CCR5-Maraviroc
26.67Single5NLXZM2413855NLX-A2A-ZM241385-Na
26.67Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
26.67Single6MH8ZM2413856MH8-A2A-ZM241385
26.67Single6PS5(S)-Propranolol6PS5-β2-(S)-Propranolol
26.67Single7AROLUF58337ARO-A2A-LUF5833-Na
26.67Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
26.67Single7XJJGalanin7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
26.67Single8GDZEpinephrine8GDZ-β2-Epinephrine-Gs/&β;1/&γ;2
26.67Single8GGKEpinephrine8GGK-β2-Epinephrine
26.67Single8GGMEpinephrine8GGM-β2-Epinephrine
26.67Single8GGPEpinephrine8GGP-β2-Epinephrine
26.67Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.67Single8UO2Epinephrine8UO2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
26.67Consensusgnrh_offOrthosteric Ligandgnrh1_off
26.67Consensusgo_galaninOrthosteric Ligand7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
26.67Consensush3_on_alloOrthosteric Ligand7F61-H3-PF-03654746-Cholesterol
26.67Consensusox2_offOrthosteric Ligand6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant
26.67Consensuspth_onOrthosteric Ligandpth1_on pth2_on
26.47Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
26.47Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
26.47Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
26.47Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
26.47Single6DDFDamgo6DDF-μ-Damgo-Gi1/&β;1/&γ;2
26.47Single6H7LDobutamine6H7L-β1-Dobutamine
26.47Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
26.47Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
26.47Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/&β;1/&γ;2
26.47Single7XJISolabegron7XJI-β3-Solabegron-Gs/&β;1/&γ;2
26.47Single7XK2MK68927XK2-HCA2-MK6892-Gi1/&β;1/&γ;2
26.47Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
26.47Single8GAGYVF8GAG-CB1-YVF-Gi1/&β;1/&γ;2
26.47Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/&β;1/&γ;2
26.47Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
26.47Consensuscyslt2_offOrthosteric Ligand6RZ6-CysLT2-ONO-2570366 6RZ9-CysLT2-ONO-2770372 6RZ8-CysLT2-ONO-2080365
26.47Consensuscyslt_offOrthosteric Ligandcyslt2_off
26.32Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
26.32Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
26.32Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
26.19Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
26.19Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
25.81Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
25.81Single2Y02Carmoterol2Y02-β1-Carmoterol
25.81Single3EMLZM2413853EML-A2A-ZM241385
25.81Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
25.81Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
25.81Single4EJ4Naltrindole4EJ4-δ-Naltrindole
25.81Single4QKXPubChem 762106284QKX-β2-PubChem 76210628
25.81Single5K2AZM2413855K2A-A2A-ZM241385-Na
25.81Single5UENDU1725UEN-A1-DU172
25.81Single5VRAZM2413855VRA-A2A-ZM241385-Na
25.81Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
25.81Single6D27CAY104716D27-DP2-CAY10471
25.81Single6LPJZM2413856LPJ-A2A-ZM241385-Na
25.81Single6LPKZM2413856LPK-A2A-ZM241385-Na
25.81Single6PS1Timolol6PS1-β2-Timolol
25.81Single6PS2(S)-Alprenolol6PS2-β2-(S)-Alprenolol
25.81Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
25.81Single6S0LZM2413856S0L-A2A-ZM241385
25.81Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
25.81Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
25.81Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
25.81Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
25.81Single7CRHSKF839597CRH-D1-SKF83959-Gs/&β;1/&γ;2
25.81Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
25.81Single7LJCPubChem 867641037LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
25.81Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
25.81Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
25.81Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/&β;1/&γ;2
25.81Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
25.81Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
25.81Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
25.81Single8CU6LJ-45178CU6-A2A-LJ-4517
25.81Single8EFQDamgo8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
25.81Single8GE3Epinephrine8GE3-β2-Epinephrine-Gs/&β;1/&γ;2
25.81Single8GEBEpinephrine8GEB-β2-Epinephrine-Gs/&β;1/&γ;2
25.81Single8GEEEpinephrine8GEE-β2-Epinephrine-Gs/&β;1/&γ;2
25.81Single8GEHEpinephrine8GEH-β2-Epinephrine-Gs/&β;1/&γ;2
25.81Single8GFWEpinephrine8GFW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.81Single8GFXEpinephrine8GFX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.81Single8GFYEpinephrine8GFY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.81Single8GFZEpinephrine8GFZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.81Single8GG0Epinephrine8GG0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.81Single8GG1Epinephrine8GG1-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.81Single8GG2Epinephrine8GG2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.81Single8GG6Epinephrine8GG6-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.81Single8GGBEpinephrine8GGB-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.81Single8GGJEpinephrine8GGJ-β2-Epinephrine
25.81Single8GGNEpinephrine8GGN-β2-Epinephrine
25.81Single8GGOEpinephrine8GGO-β2-Epinephrine
25.81Single8GGUEpinephrine8GGU-β2-Epinephrine
25.81Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
25.81Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2
25.81Single8UNMEpinephrine8UNM-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.81Single8UNNEpinephrine8UNN-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.81Single8UNPEpinephrine8UNP-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.81Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
25.81Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
25.81Consensusadenosine_onOrthosteric Liganda1_on a2_on
25.81Consensusadrenergic_onOrthosteric Ligandbeta_on alpha_on
25.81Consensuscck_offOrthosteric Ligandccka_off
25.81Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
25.81Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
25.81Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
25.81Consensusdopamine_onOrthosteric Ligandd3_on d2_on d5_on d1_on
25.81Consensusffa_onOrthosteric Ligandffa4_on ffa1_on ffa2_on ffa3_on
25.81Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
25.81Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
25.81Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
25.81Consensusgi_hcaOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
25.81Consensusgi_hcarOrthosteric Ligandgi_hca
25.81Consensushca2_onOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
25.81Consensusnucleotide_onOrthosteric Ligandadenosine_on
25.81Consensusp2y12_offOrthosteric Ligand4NTJ-P2Y12-AZD1283 7PP1-P2Y12-Selatogrel
25.81Consensustachykinin_offOrthosteric Ligandnk1_off
25.71Single5ZTYAM102575ZTY-CB2-AM10257
25.71Single6KNMJN241-96KNM-Apelin-JN241-9
25.71Single6PT3DPI-2876PT3-δ-DPI-287
25.71Single8IYHMK68928IYH-HCA2-MK6892-Go/&β;1/&γ;2
25.71Single8SAI1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
25.71Single8X5YAstemizole8X5Y-H1-Astemizole
25.71Single8XZFWN5618XZF-Apelin-WN561-Gi1/&β;1/&γ;2
25.71Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
25.71Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
25.71Consensuslpl_offOrthosteric Ligands1p_off lpa_off
25.71Consensuslpl_onOrthosteric Ligands1p_on lpa_on
25.71Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
25.71Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.64Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
25.64Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
25.64Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
25.64Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
25.64Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
25.64Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
25.58Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
25.58Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
25.58Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
25.53Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
25.00Single2RH1(S)-Carazolol2RH1-β2-(S)-Carazolol
25.00Single2YCW(S)-Carazolol2YCW-β1-(S)-Carazolol
25.00Single4NTJAZD12834NTJ-P2Y12-AZD1283
25.00Single5D6L(S)-Carazolol5D6L-β2-(S)-Carazolol
25.00Single5IUAQ274563485IUA-A2A-Q27456348-Na
25.00Single5N2RPubChem 92460631; psb365N2R-A2A-PubChem 92460631; psb36-Na
25.00Single5NM2ZM2413855NM2-A2A-ZM241385-Na
25.00Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
25.00Single5TVNLSD5TVN-5-HT2B-LSD
25.00Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
25.00Single5WIUNemonapride5WIU-D4-Nemonapride
25.00Single5WIVNemonapride5WIV-D4-Nemonapride-Na
25.00Single5X7D(S)-Carazolol5X7D-β2-(S)-Carazolol-PubChem 129318963
25.00Single6DDEDamgo6DDE-μ-Damgo-Gi1/&β;1/&γ;2
25.00Single6E67BI1671076E67-β2-BI167107-Gs (fused)
25.00Single6FJ3PTH6FJ3-PTH1-PTH
25.00Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
25.00Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
25.00Single6LPLZM2413856LPL-A2A-ZM241385-Na
25.00Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
25.00Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
25.00Single6PS3(S)-Carvedilol6PS3-β2-(S)-Carvedilol
25.00Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
25.00Single6S0QZM2413856S0Q-A2A-ZM241385
25.00Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
25.00Single6WQAZM2413856WQA-A2A-ZM241385-Na
25.00Single6Z4SSR486926Z4S-NTS1-SR48692
25.00Single7BVQ(S)-Carazolol7BVQ-β1-(S)-Carazolol
25.00Single7RM5ZM2413857RM5-A2A-ZM241385-Na
25.00Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
25.00Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2
25.00Single7SBFPZM217SBF-μ-PZM21-Gi1/&β;1/&γ;2
25.00Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
25.00Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
25.00Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
25.00Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
25.00Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
25.00Single7WC6LSD7WC6-5-HT2A-LSD
25.00Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
25.00Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
25.00Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
25.00Single8DZQmomSalB8DZQ-κ-momSalB-Go/&β;1/&γ;2
25.00Single8FYNZM2413858FYN-A2A-ZM241385-Na
25.00Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
25.00Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
25.00Single8J6RMK68928J6R-HCA2-MK6892-Gi1/&β;1/&γ;2
25.00Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
25.00Consensusadrenergic_offOrthosteric Ligandbeta_off alpha_off
25.00Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
25.00Consensusamine_offOrthosteric Ligandadrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
25.00Consensusbeta2_offOrthosteric Ligand6PS2-β2-(S)-Alprenolol 6PS3-β2-(S)-Carvedilol 6PS5-β2-(S)-Propranolol 6PS6-β2-Timolol 2RH1-β2-(S)-Carazolol 6PS4-β2-ICI 118-551 3NY9-β2-PubChem 913103
25.00Consensusbeta2_onOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
25.00Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
25.00Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
25.00Consensuscb2_onOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
25.00Consensusd4_offOrthosteric Ligand5WIU-D4-Nemonapride
25.00Consensusd4_off_alloOrthosteric Ligand5WIV-D4-Nemonapride-Na
25.00Consensusgi_adrenergicOrthosteric Ligand7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
25.00Consensusgo_opioidOrthosteric Ligand8DZQ-κ-momSalB-Go/&β;1/&γ;2
25.00Consensusgs_adrenergicOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJI-β3-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
25.00Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
25.00Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
24.44Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
24.44Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
24.44Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
24.44Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
24.39Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
24.39Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
24.39Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
24.32Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
24.32Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/&β;1/&γ;2
24.32Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
24.24Single2YDVNECA2YDV-A2A-NECA
24.24Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
24.24Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
24.24Single4UHRCGS216804UHR-A2A-CGS21680
24.24Single5G53NECA5G53-A2A-NECA-Gs
24.24Single5XR8AM8415XR8-CB1-AM841
24.24Single6E59L-7607356E59-NK1-L-760735
24.24Single6H7JIsoprenaline6H7J-β1-Isoprenaline
24.24Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
24.24Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
24.24Single6TQ7SB-3348676TQ7-OX1-SB-334867
24.24Single7B6WCyclazosin7B6W-α1b-Cyclazosin
24.24Single7CKYPW04647CKY-D1-PW0464-Gs/&β;1/&γ;2
24.24Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2
24.24Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
24.24Single7F1TMIP-1a7F1T-CCR5-MIP-1a
24.24Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2
24.24Single7PX4PSB-21137PX4-A2A-PSB-2113
24.24Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
24.24Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
24.24Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2
24.24Single7W6PW967W6P-α2a-W96-Go/&β;1/&γ;2
24.24Single7W7EW587W7E-α2a-W58-Go/&β;1/&γ;2
24.24Single7WV9PubMed 1048957WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
24.24Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
24.24Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
24.24Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
24.24Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
24.24Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2
24.24Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/&β;1/&γ;2
24.24Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
24.24Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/&β;1/&γ;2
24.24Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
24.24Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
24.24Consensusadenosine_offOrthosteric Liganda1_off a2_off
24.24Consensusalpha1b_offOrthosteric Ligand7B6W-α1b-Cyclazosin
24.24Consensusdopamine_offOrthosteric Ligandd3_off d2_off d4_off
24.24Consensusgi_amineOrthosteric Ligandgi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
24.24Consensusgi_muscarinicOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
24.24Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A-NECA-Gs/&β;1/&γ;1 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
24.24Consensusgs_ffaOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2 8GDB-EP4-PGE2-Gs/&β;1/&γ;2
24.24Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
24.24Consensusnts1_on_alloOrthosteric Ligand8JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
24.24Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
24.24Consensussst4_onOrthosteric Ligand7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
24.14Single3OE9IT1t3OE9-CXCR4-IT1t
24.14Single6HLLCP999946HLL-NK1-CP99994
24.14Single7UL2SR486927UL2-NTS1-SR48692-Na
24.14Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
24.14Single8GGCEpinephrine8GGC-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
24.14Single8GGEEpinephrine8GGE-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
24.14Consensusm4_on_alloOther Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
24.14Consensusnts1_off_alloOrthosteric Ligand7UL2-NTS1-SR48692-Na
23.91Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
23.81Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
23.81Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
23.81Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
23.81Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
23.68Single6W25SHU91196W25-MC4-SHU9119-Ca
23.68Consensusmc5_onOrthosteric Ligand8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
23.53Single4LDEBI1671074LDE-β2-BI167107
23.53Single4PY02MeSATP4PY0-P2Y12-2MeSATP
23.53Single6HLPNetupitant6HLP-NK1-Netupitant
23.53Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
23.53Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
23.53Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
23.53Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
23.53Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
23.53Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
23.53Single7WCNAR2314537WCN-GPR119-AR231453-Gs/&β;1/&γ;2
23.53Single7XMTJ-21567XMT-SST4-J-2156-Gi1/&β;1/&γ;2
23.53Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
23.53Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
23.53Single8IJDMK68928IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
23.53Single8JWYPubChem 1684517108JWY-A2A-PubChem 168451710
23.53Single8JWZAB9288JWZ-A2A-AB928-Na
23.53Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
23.53Consensusbeta1_onOrthosteric Ligand7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
23.53Consensusgs_trhOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
23.53Consensusleuko_offOrthosteric Ligandblt_off cyslt_off
23.53Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
23.53Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
23.33Single2X72All-trans-retinal2X72-Rhodopsin-All-trans-retinal-Gt(CT)
23.33Single3VGAZM2413853VGA-A2A-ZM241385-Antibody
23.33Single4BWBNeurotensin4BWB-NTS1-Neurotensin
23.33Single5K2DZM2413855K2D-A2A-ZM241385
23.33Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
23.33Single6AKXA4R6AKX-CCR5-A4R
23.33Single6AKYMaraviroc6AKY-CCR5-Maraviroc
23.33Single6JZHZM2413856JZH-A2A-ZM241385-Na
23.33Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
23.33Single6PS7ZM2413856PS7-A2A-ZM241385-Na
23.33Single7BR3Elagolix7BR3-GnRH1-Elagolix
23.33Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2
23.33Single7F8ULintitript7F8U-CCKA-Lintitript
23.33Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
23.33Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.33Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
23.33Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
23.33Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
23.33Single7W0OElabela7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
23.33Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2
23.33Single7XRRLemborexant7XRR-OX2-Lemborexant
23.33Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
23.33Single8EFOPZM218EFO-μ-PZM21-Gi1/&β;1/&γ;2
23.33Single8FN0Neurotensin/neuromedin N8FN0-NTS1-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
23.33Single8GEDEpinephrine8GED-β2-Epinephrine-Gs/&β;1/&γ;2
23.33Single8GG7Epinephrine8GG7-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
23.33Single8GGFEpinephrine8GGF-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
23.33Single8GGWEpinephrine8GGW-β2-Epinephrine
23.33Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
23.33Single8UNLEpinephrine8UNL-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
23.33Single8UNOEpinephrine8UNO-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
23.33Single8UNTEpinephrine8UNT-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
23.33Single8UNUEpinephrine8UNU-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
23.33Single8UO0Epinephrine8UO0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
23.33Single8UO1Epinephrine8UO1-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
23.33Single8UO3Epinephrine8UO3-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
23.33Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
23.33Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
23.33Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
23.33Consensusgi_nucleotideOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
23.33Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
23.33Consensusorexin_offOrthosteric Ligandox2_off ox1_off
23.08Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
23.08Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
23.08Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
22.92Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
22.86Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
22.86Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
22.86Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
22.86Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
22.86Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.86Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
22.86Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
22.86Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
22.86Single8E9YPubChem 4466038E9Y-M3-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.86Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
22.86Consensusendothelin_offOrthosteric Ligandetb_off
22.86Consensusetb_offOrthosteric Ligand5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500 5X93-ETB-K-8794
22.86Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
22.73Consensusglp_onOrthosteric Ligandglp1_on glp2_on
22.58Single4DKLBeta-funaltrexamine4DKL-μ-Beta-funaltrexamine
22.58Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
22.58Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
22.58Single4ZJCSB-6740424ZJC-OX1-SB-674042
22.58Single5IU4ZM2413855IU4-A2A-ZM241385-Na
22.58Single5IU7Q274563465IU7-A2A-Q27456346-Na
22.58Single5IUBQ274563445IUB-A2A-Q27456344-Na
22.58Single5JTBZM2413855JTB-A2A-ZM241385
22.58Single5K2BZM2413855K2B-A2A-ZM241385-Na
22.58Single5K2CZM2413855K2C-A2A-ZM241385-Na
22.58Single5NM4ZM2413855NM4-A2A-ZM241385-Na
22.58Single5UVIZM2413855UVI-A2A-ZM241385
22.58Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
22.58Single6PS4ICI 118-5516PS4-β2-ICI 118-551
22.58Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
22.58Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
22.58Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
22.58Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
22.58Single6ZDVPubChem 9840736ZDV-A2A-PubChem 984073-Na
22.58Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
22.58Single7BB6Acyclovir triphosphate7BB6-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
22.58Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/&β;1/&γ;2
22.58Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
22.58Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
22.58Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
22.58Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/&β;1/&γ;2
22.58Single7JOZVFP7JOZ-D1-VFP-Gs/&β;1/&γ;2
22.58Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.58Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
22.58Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
22.58Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
22.58Single7VV6C48/807VV6-MRGPRX2-C48/80
22.58Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
22.58Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
22.58Single8GE1Epinephrine8GE1-β2-Epinephrine-Gs/&β;1/&γ;2
22.58Single8GE4Epinephrine8GE4-β2-Epinephrine-Gs/&β;1/&γ;2
22.58Single8GE6Epinephrine8GE6-β2-Epinephrine-Gs/&β;1/&γ;2
22.58Single8GE7Epinephrine8GE7-β2-Epinephrine-Gs/&β;1/&γ;2
22.58Single8GE8Epinephrine8GE8-β2-Epinephrine-Gs/&β;1/&γ;2
22.58Single8GE9Epinephrine8GE9-β2-Epinephrine-Gs/&β;1/&γ;2
22.58Single8GEGEpinephrine8GEG-β2-Epinephrine-Gs/&β;1/&γ;2
22.58Single8GFVEpinephrine8GFV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.58Single8GG3Epinephrine8GG3-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.58Single8GG4Epinephrine8GG4-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.58Single8GG5Epinephrine8GG5-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.58Single8GG8Epinephrine8GG8-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.58Single8GGIEpinephrine8GGI-β2-Epinephrine
22.58Single8GGLEpinephrine8GGL-β2-Epinephrine
22.58Single8GGQEpinephrine8GGQ-β2-Epinephrine
22.58Single8GGTEpinephrine8GGT-β2-Epinephrine
22.58Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2
22.58Single8GURPubChem 1048958GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2
22.58Single8HQN9(S)-HODE8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
22.58Single8JIMMMF8JIM-HCA2-MMF-Gi1/&β;1/&γ;2
22.58Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
22.58Single8K4NVF08K4N-GPR34-VF0-Gi1/&β;1/&γ;2
22.58Single8UNQEpinephrine8UNQ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.58Single8UNREpinephrine8UNR-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.58Single8UNSEpinephrine8UNS-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.58Single8UNZEpinephrine8UNZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.58Consensusd1_on_alloOrthosteric Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
22.58Consensusd3_onOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
22.58Consensusdop_off_alloOrthosteric Ligand4N6H-δ-Naltrindole-Na
22.58Consensusffa2_onOrthosteric Ligand8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
22.58Consensushca_onOrthosteric Ligandhca2_on hca3_on
22.58Consensushcar_onOrthosteric Ligandhca_on
22.58Consensusm1_off_alloOther Ligand6WJC-M1-Atropine-Muscarinic toxin 7
22.58Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
22.58Consensusox1_offOrthosteric Ligand6TOT-OX1-Lemborexant 6TP4-OX1-ACT-462206 6TP6-OX1-Filorexant 6V9S-OX1-GTPL11403 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ7-OX1-SB-334867 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant
22.50Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
22.45Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
22.22Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
22.22Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
22.22Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
22.22Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.22Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
22.22Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
22.22Consensusclass-d_offOrthosteric Ligandste2_off
22.22Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
21.95Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
21.95Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/&β;1/&γ;2
21.95Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
21.95Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
21.95Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
21.95Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
21.95Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
21.95Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
21.88Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
21.88Single3NY8ICI 118-5513NY8-β2-ICI 118-551
21.88Single3NYA(S)-Alprenolol3NYA-β2-(S)-Alprenolol
21.88Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
21.88Single4EIYZM2413854EIY-A2A-ZM241385-Na
21.88Single4GBR(S)-Carazolol4GBR-β2-(S)-Carazolol
21.88Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
21.88Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
21.88Single5DHGPubChem 250014125DHG-NOP-PubChem 25001412
21.88Single5IU8Q274563475IU8-A2A-Q27456347-Na
21.88Single5JQH(S)-Carazolol5JQH-β2-(S)-Carazolol
21.88Single5OLGZM2413855OLG-A2A-ZM241385-Na
21.88Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
21.88Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
21.88Single5UIGJ3.651.884G5UIG-A2A-J3.651.884G
21.88Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
21.88Single6H7MSalbutamol6H7M-β1-Salbutamol
21.88Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2
21.88Single6PRZ(S)-Alprenolol6PRZ-β2-(S)-Alprenolol
21.88Single6PS0(S)-Carazolol6PS0-β2-(S)-Carazolol
21.88Single6TOTLemborexant6TOT-OX1-Lemborexant
21.88Single7BU7BI1671077BU7-β1-BI167107
21.88Single7CFMP3957CFM-GPBA-P395-Gs/&β;1/&γ;2
21.88Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
21.88Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
21.88Single7PYRPSB-21157PYR-A2A-PSB-2115
21.88Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
21.88Single7SCGFH2107SCG-μ-FH210-Gi1/&β;1/&γ;2
21.88Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
21.88Single7UL4Alvimopan7UL4-μ-Alvimopan
21.88Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
21.88Single7V3ZPubMed 1048957V3Z-CB1-PubMed 104895
21.88Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
21.88Single7WC7Lisuride7WC7-5-HT2A-Lisuride
21.88Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
21.88Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
21.88Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
21.88Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
21.88Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/&β;1/&γ;2
21.88Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
21.88Single8JJOAlprenolol8JJO-β2-Alprenolol
21.88Single8JLZST19368JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
21.88Single8K5DGSK2560738K5D-HCA2-GSK256073
21.88Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
21.88Single8UO4Epinephrine8UO4-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
21.88Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
21.88Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
21.88Consensus5ht1a_onOrthosteric Ligand8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
21.88Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
21.88Consensusa2_offOrthosteric Liganda2a_off
21.88Consensusa2a_offOrthosteric Ligand8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 5UIG-A2A-J3.651.884G 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-PubChem 168451710 5K2D-A2A-ZM241385
21.88Consensusalpha2_onOrthosteric Ligandalpha2a_on alpha2b_on
21.88Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
21.88Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
21.88Consensusamine_onOrthosteric Ligandadrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
21.88Consensuscb1_on_alloOrthosteric Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
21.88Consensusgi_5htOrthosteric Ligand7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
21.88Consensushca3_onOrthosteric Ligand8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
21.88Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
21.88Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
21.88Consensussmo_offOrthosteric Ligand5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
21.88Consensustar_onOrthosteric Ligandta1_on
21.74Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
21.62Single7QA8Peptide7QA8-STE2-Peptide
21.62Single7QA8Peptide7QA8-STE2-Peptide
21.62Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
21.62Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
21.62Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
21.62Consensusclass-d_offOrthosteric Ligandste2_off
21.62Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
21.57Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
21.43Single6TQ9SB-4081246TQ9-OX1-SB-408124
21.43Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
21.43Consensusgo_class-b1Orthosteric Ligandgo_crf
21.43Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
21.43Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
21.21Single2Y03Isoprenaline2Y03-β1-Isoprenaline
21.21Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
21.21Single5WQCEMPA5WQC-OX2-EMPA
21.21Single6GDGNECA6GDG-A2A-NECA-Gs/&β;1/&γ;1
21.21Single6PS6Timolol6PS6-β2-Timolol
21.21Single6TP6Filorexant6TP6-OX1-Filorexant
21.21Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
21.21Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
21.21Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
21.21Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
21.21Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
21.21Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
21.21Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
21.21Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
21.21Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
21.21Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide 6DRX-5-HT2B-Lisuride
21.21Consensusa2a_onOrthosteric Ligand6GDG-A2A-NECA-Gs/&β;1/&γ;1
21.21Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
21.05Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.93Single6LMLGlucagon6LML-Glucagon-Glucagon
20.93Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
20.93Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
20.93Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
20.93Consensuscrf1_onOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
20.69Single3OE6IT1t3OE6-CXCR4-IT1t
20.69Single4XNWMRS25004XNW-P2Y1-MRS2500
20.69Single6ME5Agomelatine6ME5-MT1-Agomelatine
20.69Single6ME9Ramelteon6ME9-MT2-Ramelteon
20.69Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
20.69Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
20.69Single8F76-8F76-OR51E2-Gs/&β;1/&γ;2
20.69Single8GGREpinephrine8GGR-β2-Epinephrine
20.69Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
20.69Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
20.59Single4DJHJDTic4DJH-κ-JDTic
20.59Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
20.59Single5V56TC1145V56-SMO-TC114
20.59Single5XRAAM115425XRA-CB1-AM11542
20.59Single7EW7PubChem 40774607EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
20.59Single7FEEPubMed 1048957FEE-CB1-PubMed 104895-ZCZ011
20.59Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
20.59Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
20.59Single8DZPmomSalB8DZP-κ-momSalB-Gi1/&β;1/&γ;2
20.59Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
20.59Single8GUSHU-3088GUS-CB2-HU-308-Gi1/&β;1/&γ;2
20.59Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2
20.59Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
20.59Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
20.59Single8JXVClozapine8JXV-H4-Clozapine-Gi1/&β;1/&γ;2
20.59Consensus5ht_offOrthosteric Ligand5ht2_off 5ht5_off 5ht1_off
20.59Consensusangiotensin_offOrthosteric Ligandat1_off at2_off
20.59Consensusgo_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
20.59Consensush1_offOrthosteric Ligand3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole 8X63-H1-Mepyramine 8X64-H1-Desloratadine
20.59Consensushistamine_offOrthosteric Ligandh1_off
20.59Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
20.59Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
20.59Consensuslpa_offOrthosteric Ligandlpa1_off
20.59Consensuslpa_onOrthosteric Ligandlpa1_on
20.59Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
20.51Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
20.51Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
20.51Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
20.45Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
20.00Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
20.00Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
20.00Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
20.00Single6A93Risperidone6A93-5-HT2A-Risperidone
20.00Single6H7N(S)-Xamoterol6H7N-β1-(S)-Xamoterol
20.00Single6KQIPubMed 1048956KQI-CB1-PubMed 104895-ORG27569
20.00Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
20.00Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
20.00Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
20.00Single6ZG4HTL00099366ZG4-M1-HTL0009936
20.00Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
20.00Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
20.00Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
20.00Single7SRQLSD7SRQ-5-HT2B-LSD
20.00Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
20.00Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
20.00Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/&β;1/&γ;2
20.00Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2
20.00Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2
20.00Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/&β;1/&γ;2
20.00Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
20.00Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Single8EF6Morphine8EF6-μ-Morphine-Gi1/&β;1/&γ;2
20.00Single8GEIEpinephrine8GEI-β2-Epinephrine-Gs/&β;1/&γ;2
20.00Single8GGSEpinephrine8GGS-β2-Epinephrine
20.00Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2
20.00Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
20.00Single8IJANiacin8IJA-HCA2-Niacin-Gi1/&β;1/&γ;2
20.00Single8IY9Niacin8IY9-HCA2-Niacin-Go/&β;1/&γ;2
20.00Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Single8K5BNiacin8K5B-HCA2-Niacin
20.00Single8UNVEpinephrine8UNV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.00Consensus5ht4_onOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
20.00Consensusat2_offOrthosteric Ligand7JNI-AT2-Olodanrigan
20.00Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
20.00Consensuscb1_off_alloOrthosteric Ligand6KQI-CB1-PubMed 104895-ORG27569
20.00Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
20.00Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
19.61Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
19.57Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
19.57Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
19.51Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
19.51Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
19.51Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
19.51Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
19.51Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
19.44Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
19.44Single6K1QIRL25006K1Q-ETB-IRL2500
19.44Consensusgs_lipidOrthosteric Ligandgs_ffa gs_prostanoid
19.35Single3ODUIT1t3ODU-CXCR4-IT1t
19.35Single3PWHZM2413853PWH-A2A-ZM241385
19.35Single5DHHSB-6121115DHH-NOP-SB-612111
19.35Single5WS3EMPA5WS3-OX2-EMPA
19.35Single5ZKQABT-4915ZKQ-PAF-ABT-491
19.35Single6B73PubChem 1319551386B73-κ-PubChem 131955138
19.35Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/&β;1/&γ;2
19.35Single6ME2Ramelteon6ME2-MT1-Ramelteon
19.35Single6NWEOctyl Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
19.35Single6OBA(S)-Alprenolol6OBA-β2-(S)-Alprenolol-GTPL11074
19.35Single6TODEMPA6TOD-OX1-EMPA-Na
19.35Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
19.35Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/&β;1/&γ;2
19.35Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
19.35Single7TUZ7alpha,25-dihydroxycholesterol7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
19.35Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
19.35Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
19.35Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
19.35Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
19.35Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
19.35Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
19.35Single8GEAEpinephrine8GEA-β2-Epinephrine-Gs/&β;1/&γ;2
19.35Single8GECEpinephrine8GEC-β2-Epinephrine-Gs/&β;1/&γ;2
19.35Single8GEFEpinephrine8GEF-β2-Epinephrine-Gs/&β;1/&γ;2
19.35Single8GG9Epinephrine8GG9-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
19.35Single8GGAEpinephrine8GGA-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
19.35Single8GGVEpinephrine8GGV-β2-Epinephrine
19.35Single8GGXEpinephrine8GGX-β2-Epinephrine
19.35Single8GH0Epinephrine8GH0-β2-Epinephrine
19.35Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/&β;1/&γ;2
19.35Single8IHKAcifran8IHK-HCA3-Acifran
19.35Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2
19.35Single8IW4Spermidine8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
19.35Single8IWESpermidine8IWE-TAAR9-Spermidine
19.35Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/&β;1/&γ;2
19.35Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
19.35Single8UNWEpinephrine8UNW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
19.35Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
19.35Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
19.35Consensus5ht2c_onOrthosteric Ligand8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
19.35Consensusa2a_off_alloOrthosteric Ligand6ZDR-A2A-HMS1413f12-Na 6GT3-A2A-Imaradenant-Na 8CU7-A2A-LJ-4517-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PubChem 92460631; psb36-Na 5MZJ-A2A-Theophylline-Na 5OLO-A2A-Tozadenant-Na 5OLH-A2A-Vipadenant-Na 5NM4-A2A-ZM241385-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5MZP-A2A-Caffeine-Na 8CIC-A2A-Etrumadenant-Na
19.35Consensusbeta2_off_alloOrthosteric Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
19.35Consensusgs_5htOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
19.35Consensusmglu_onOther Ligandmglu2_on mglu4_on
19.05Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
19.05Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
19.05Single7D3SSecretin7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
19.05Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
19.05Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
19.05Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
19.05Consensusclass-d_onOrthosteric Ligandste2_on
18.92Single8INRAlpha-MSH8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
18.75Single2YDOAdenosine2YDO-A2A-Adenosine
18.75Single3REYPubChem 56973REY-A2A-PubChem 5697
18.75Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
18.75Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
18.75Single5TE3Octyl Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
18.75Single6A94Zotepine6A94-5-HT2A-Zotepine
18.75Single6AQFZM2413856AQF-A2A-ZM241385
18.75Single6DS0Ly2660976DS0-5-HT2B-Ly266097
18.75Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
18.75Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
18.75Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
18.75Single6TPGEMPA6TPG-OX2-EMPA
18.75Single6TPNHTL66416TPN-OX2-HTL6641
18.75Single6V9SGTPL114036V9S-OX1-GTPL11403
18.75Single6VI4JDTic6VI4-κ-JDTic
18.75Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
18.75Single6ZINSR486926ZIN-NTS1-SR48692
18.75Single7CMVPD1289077CMV-D3-PD128907-Gi1/&β;1/&γ;2
18.75Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
18.75Single7F0TDopamine7F0T-D1-Dopamine-Gs/&β;1/&γ;2
18.75Single7T32ZM2413857T32-A2A-ZM241385
18.75Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
18.75Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
18.75Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
18.75Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.75Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
18.75Single8JERAcipimox8JER-HCA2-Acipimox-Go/&β;1/&γ;2
18.75Single8JHNMMF8JHN-HCA2-MMF-Go/&β;1/&γ;2
18.75Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
18.75Single8JLNT1AM8JLN-TA1-T1AM-Gs/&β;1/&γ;2
18.75Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2
18.75Single8K5CAcipimox8K5C-HCA2-Acipimox
18.75Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.75Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.75Single8UHBRO52563908UHB-TA1-RO5256390-Gs/&β;1/&γ;2
18.75Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/&β;1/&γ;2
18.75Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
18.75Consensus5ht5_onOrthosteric Ligand5ht5a_on
18.75Consensus5ht5a_onOrthosteric Ligand7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
18.75Consensusalpha2b_onOrthosteric Ligand6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
18.75Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
18.75Consensusgs_tarOrthosteric Ligand8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
18.75Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
18.75Consensuss1p_offOrthosteric Ligands1p1_off
18.60Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
18.60Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
18.60Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
18.60Consensusgi_class-dOrthosteric Ligandgi_ste
18.60Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
18.42Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
18.18Single2Y04Salbutamol2Y04-β1-Salbutamol
18.18Single4X1HNonyl Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
18.18Single4YAYZD-71554YAY-AT1-ZD-7155
18.18Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
18.18Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
18.18Single5T04Neurotensin5T04-NTS1-Neurotensin
18.18Single6DRXLisuride6DRX-5-HT2B-Lisuride
18.18Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
18.18Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
18.18Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
18.18Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
18.18Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
18.18Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
18.18Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
18.18Single7T2GMitragynine pseudoindoxyl7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
18.18Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
18.18Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
18.18Single7VKTLTB47VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
18.18Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
18.18Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
18.18Single8EJKTAK-8758EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
18.18Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
18.18Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/&β;1/&γ;2
18.18Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/&β;1/&γ;2
18.18Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
18.18Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
18.18Single8X63Mepyramine8X63-H1-Mepyramine
18.18Single8X64Desloratadine8X64-H1-Desloratadine
18.18Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
18.18Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
18.18Consensusblt_onOrthosteric Ligandblt1_on
18.18Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
18.18Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
18.18Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
18.18Consensusleuko_onOrthosteric Ligandblt_on
18.18Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
18.00Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
17.95Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
17.86Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
17.86Single8GEJEpinephrine8GEJ-β2-Epinephrine-Gs/&β;1/&γ;2
17.78Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
17.65Single2Y00Dobutamine2Y00-β1-Dobutamine
17.65Single4JKVTaladegib (LY2940680)4JKV-SMO-Taladegib (LY2940680)
17.65Single5XPRBosentan5XPR-ETB-Bosentan
17.65Single5ZK3Quinuclidinyl benzilate hydrobromide5ZK3-M2-Quinuclidinyl benzilate hydrobromide
17.65Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
17.65Single7C4SS1P7C4S-S1P3-S1P
17.65Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
17.65Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
17.65Single8J19PubChem 1270454228J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
17.65Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
17.65Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.65Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
17.65Consensusalpha2a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
17.65Consensusgo_amineOrthosteric Ligandgo_adrenergic go_muscarinic go_5ht
17.24Single3RFMCaffeine3RFM-A2A-Caffeine
17.24Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
17.24Single8A2OTheophylline8A2O-A2A-Theophylline-Na
17.24Consensushca2_on_alloOrthosteric Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
17.14Single3UONQuinuclidinyl benzilate hydrobromide3UON-M2-Quinuclidinyl benzilate hydrobromide
17.14Single4U15Tiotropium4U15-M3-Tiotropium
17.14Single5TZR-5TZR-FFA1 (GPR40)-MK8666
17.14Single5V54Methiothepin5V54-5-HT1B-Methiothepin
17.14Single5V57TC1145V57-SMO-TC114
17.14Single5X93K-87945X93-ETB-K-8794
17.14Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
17.14Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
17.14Single6OL9Tiotropium6OL9-M5-Tiotropium
17.14Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
17.14Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
17.14Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
17.14Single7W41PD1762527W41-BB2-PD176252
17.14Single8EFLSR170188EFL-μ-SR17018-Gi1/&β;1/&γ;2
17.14Single8G056-OAU8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
17.14Single8JD0J9R8JD0-mGlu2; mGlu3-Glutamate-J9R
17.14Single8JXWVUF68848JXW-H4-VUF6884-Gi1/&β;1/&γ;2
17.14Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/&β;1/&γ;2
17.14Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
17.14Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.14Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
17.14Consensus5ht1_offOrthosteric Ligand5ht1b_off
17.14Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
17.14Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
17.14Consensusbombesin_offOrthosteric Ligandbb2_off
17.14Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl Scopolamine 5ZHP-M3-PubChem 134828589
17.14Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
17.14Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
17.07Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
17.02Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
16.67Single3OE8IT1t3OE8-CXCR4-IT1t
16.67Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
16.67Single5CXVTiotropium5CXV-M1-Tiotropium
16.67Single5WKTOctyl Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
16.67Single6CM4Risperidone6CM4-D2-Risperidone
16.67Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
16.67Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
16.67Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
16.67Single7DFPSpiperone7DFP-D2-Spiperone
16.67Single7S8O(R)-Zinc-35737S8O-MRGPRX2-(R)-Zinc-3573-Gi1/&β;1/&γ;2
16.67Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
16.67Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67Single8EITDoconexent8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
16.67Single8GGZEpinephrine8GGZ-β2-Epinephrine
16.67Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
16.67Single8J6QBeta-hydroxybutyrate8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
16.67Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg3_on
16.67Consensusclass-b2_onOrthosteric Ligandadgrg_on
16.67Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
16.67Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
16.67Consensusgi_class-fOther Ligandgi_frizzled
16.67Consensusgi_frizzledOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
16.67Consensusgi_prostanoidOrthosteric Ligand8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GDC-EP3-PGE2-Gi1/&β;1/&γ;2 8GCM-EP4-L902688-Gi1/&β;1/&γ;2
16.67Consensusgpr119_onOrthosteric Ligand7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
16.67Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
16.33Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
16.28Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
16.22Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
16.22Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
16.22Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
16.22Single7XZ6APD6687XZ6-GPR119-APD668-Gs/&β;1/&γ;2
16.22Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
16.22Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
16.13Single3PBLEticlopride3PBL-D3-Eticlopride
16.13Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
16.13Single6QNOAll-trans-retinal6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
16.13Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
16.13Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
16.13Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2
16.13Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
16.13Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
16.13Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.13Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
16.13Single8GGYEpinephrine8GGY-β2-Epinephrine
16.13Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2
16.13Single8JILNiacin8JIL-HCA2-Niacin-Gi1/&β;1/&γ;2
16.13Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
16.13Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
16.13Single8UNXEpinephrine8UNX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
16.13Consensusclass-t_onOrthosteric Ligandtaste2_on
16.13Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
16.13Consensusgo_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
16.13Consensusgo_proteinOrthosteric Ligandgo_chemokine
16.13Consensusgs_class-tOrthosteric Ligandgs_taste
16.13Consensusgs_tasteOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
16.13Consensusmt2_onOrthosteric Ligand7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
16.13Consensusox1_off_alloOrthosteric Ligand6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na 6TO7-OX1-Suvorexant-Na
16.13Consensustaste2_onOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
16.00Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
15.91Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
15.91Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
15.79Single5EE7MK08935EE7-Glucagon-MK0893
15.79Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
15.79Single7SK9CCX6627SK9-ACKR3-CCX662
15.79Consensusgs_adgrOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
15.79Consensusgs_class-b2Orthosteric Ligandgs_adgr
15.62Single3VG9ZM2413853VG9-A2A-ZM241385-Antibody
15.62Single4S0VSuvorexant4S0V-OX2-Suvorexant
15.62Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
15.62Single6KUXRS-799486KUX-α2a-RS-79948
15.62Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
15.62Single6TPJSuvorexant6TPJ-OX2-Suvorexant
15.62Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
15.62Single6WWZCCL206WWZ-CCR6-CCL20-Go/&β;1/&γ;2
15.62Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
15.62Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2
15.62Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
15.62Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;1
15.62Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
15.62Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
15.62Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
15.62Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
15.62Consensus5ht2_onOrthosteric Ligand5ht2a_on 5ht2c_on
15.62Consensusalpha1_onOrthosteric Ligandalpha1a_on
15.62Consensusalpha1a_onOrthosteric Ligand7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.62Consensusalpha2_offOrthosteric Ligandalpha2a_off alpha2c_off
15.62Consensusalpha2a_offOrthosteric Ligand6KUX-α2a-RS-79948
15.62Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
15.62Consensusclass-f_offOrthosteric Ligandsmo_off
15.62Consensusffa3_on_alloOrthosteric Ligand8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
15.62Consensusmelatonin_onOrthosteric Ligandmt1_on mt2_on
15.56Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
15.38Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
15.22Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
15.22Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
15.22Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
15.22Consensusgs_crfOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
15.15Single3RZECidoxepin3RZE-H1-Cidoxepin
15.15Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
15.15Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
15.15Single6IQLL7458706IQL-D4-L745870
15.15Single6TP3Nemorexant6TP3-OX1-Nemorexant
15.15Single6TPKRetosiban6TPK-OT-Retosiban
15.15Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
15.15Single6ZG9GSK10347026ZG9-M1-GSK1034702
15.15Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
15.15Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2
15.15Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
15.15Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.15Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
15.15Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2
15.15Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
15.15Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.15Single8T3VDHA8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.15Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
15.15Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6WH4-5-HT2A-Methiothepin 7VOE-5-HT2A-Aripiprazole 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 6A93-5-HT2A-Risperidone
15.15Consensus5ht2a_onOrthosteric Ligand7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.15Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
15.15Consensusgi_melatoninOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
15.15Consensusm1_off_alloOrthosteric Ligand6WJC-M1-Atropine-Muscarinic toxin 7
15.15Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
15.15Consensusvasopressin-ot_offOrthosteric Ligandot_off
15.00Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
14.71Single2Y01Dobutamine2Y01-β1-Dobutamine
14.71Single4DAJTiotropium4DAJ-M3-Tiotropium
14.71Single4MQSIperoxo4MQS-M2-Iperoxo
14.71Single4U14Tiotropium4U14-M3-Tiotropium
14.71Single4U16N-Methyl Scopolamine4U16-M3-N-Methyl Scopolamine
14.71Single5YC8N-Methyl Scopolamine5YC8-M2-N-Methyl Scopolamine
14.71Single5ZK8N-Methyl Scopolamine5ZK8-M2-N-Methyl Scopolamine
14.71Single5ZKCN-Methyl Scopolamine5ZKC-M2-N-Methyl Scopolamine
14.71Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
14.71Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.71Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
14.71Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
14.71Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
14.71Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
14.71Single8EJCTAK-8758EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
14.71Single8J18(3R)-3-hydroxydodecanoic acid8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
14.71Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
14.71Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
14.71Consensusgo_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
14.71Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
14.71Consensushistamine_onOrthosteric Ligandh1_on h4_on
14.71Consensusm2_on_alloOrthosteric Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
14.71Consensusm4_on_alloOrthosteric Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
14.71Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
14.71Consensusprostanoid_offOrthosteric Ligandep_off tp_off dp_off
14.58Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single4PHUFasiglifam4PHU-FFA1 (GPR40)-Fasiglifam
14.29Single6LUQHaloperidol6LUQ-D2-Haloperidol
14.29Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
14.29Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
14.29Single7SINNPS-21437SIN-CaS-NPS-2143
14.29Single7SINNPS-21437SIN-CaS-NPS-2143
14.29Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2
14.29Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
14.29Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single7YXAONO-54306087YXA-S1P5-ONO-5430608
14.29Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.29Single8EA0Iperoxo8EA0-M3-Iperoxo
14.29Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
14.29Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2
14.29Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
14.29Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.29Consensusclass-d_onOrthosteric Ligandste2_on
14.29Consensusgi_class-dOrthosteric Ligandgi_ste
14.29Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
14.29Consensusgs_muscarinicOrthosteric Ligand8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.29Consensusm2_offOrthosteric Ligand5ZKB-M2-AF-DX 384 5ZKC-M2-N-Methyl Scopolamine 5ZK3-M2-Quinuclidinyl benzilate hydrobromide
14.29Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.29Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
13.89Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
13.89Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
13.89Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
13.89Single7EPENAM5637EPE-mGlu-NAM563
13.89Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
13.89Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
13.79Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
13.79Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/&β;1/&γ;2
13.79Single8PWNTheophylline8PWN-A2A-Theophylline
13.64Consensusghrh_onOrthosteric Ligand7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
13.51Single4N4WSANT-14N4W-SMO-SANT-1
13.51Single7K15MKD0467K15-BLT1-MKD046-Na
13.51Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
13.51Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
13.51Single8GCPPGE28GCP-EP4-PGE2-Gi1/&β;1/&γ;2
13.51Consensusblt1_offOrthosteric Ligand7K15-BLT1-MKD046-Na
13.51Consensusblt_offOrthosteric Ligandblt1_off
13.33Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
13.33Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
13.33Single7VDMSubstance P7VDM-MRGPRX2-Substance P-Gi1/&β;1/&γ;2
13.33Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.33Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
13.21Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
13.16Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
13.16Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.16Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.16Consensusadgrg2_onOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
13.16Consensusep4_onOrthosteric Ligand7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2
13.16Consensusgs_prostanoidOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.04Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
13.04Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
13.04Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
12.90Single3UZAGTPL92363UZA-A2A-GTPL9236
12.90Single6FUFAll-trans-retinal6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2
12.90Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/&β;1/&γ;2
12.90Single7WC5Psilocin7WC5-5-HT2A-Psilocin
12.90Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.90Single8POKHistamine8POK-H2-Histamine-Gs/&β;1/&γ;2
12.90Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
12.90Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.90Consensussmo_off_alloOrthosteric Ligand6D32-SMO-Cyclopamine-Cyclopamine
12.50Single4O9RCyclopamine4O9R-SMO-Cyclopamine
12.50Single5L7IVismodegib5L7I-SMO-Vismodegib
12.50Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
12.50Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
12.50Single6TP4ACT-4622066TP4-OX1-ACT-462206
12.50Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
12.50Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
12.50Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
12.50Single7S8N(R)-Zinc-35737S8N-MRGPRX2-(R)-Zinc-3573-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.50Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Single8HN8Histamine8HN8-H4-Histamine-Gi1/&β;1/&γ;2
12.50Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
12.50Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
12.50Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
12.50Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
12.50Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
12.50Consensusmt1_onOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
12.50Consensussmo_on_alloOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
12.20Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
12.20Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
12.12Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
12.12Single4QINSAG1.54QIN-SMO-SAG1.5
12.12Single5U09Taranabant5U09-CB1-Taranabant
12.12Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
12.12Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
12.12Single6OYAAll-trans-retinal6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
12.12Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
12.12Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
12.12Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
12.12Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
12.12Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
12.12Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
12.12Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
12.12Single8DWHCompound-168DWH-MRGPRX1-Compound-16-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.12Single8HOCImetit8HOC-H4-Imetit-Gi1/&β;1/&γ;2
12.12Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
12.12Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
12.12Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
12.12Consensusgi_histamineOrthosteric Ligand8HN8-H4-Histamine-Gi1/&β;1/&γ;2 8HOC-H4-Imetit-Gi1/&β;1/&γ;2
12.12Consensusgs_histamineOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.12Consensusgt_class-aOrthosteric Ligandgt_opsin
12.12Consensusgt_opsinOrthosteric Ligandgt_sensory
12.12Consensusgt_sensoryOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
12.12Consensush4_onOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.12Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
11.76Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
11.76Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
11.76Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
11.76Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
11.76Single8GCML9026888GCM-EP4-L902688-Gi1/&β;1/&γ;2
11.76Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.76Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
11.76Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
11.76Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
11.76Consensusgi_class-fOrthosteric Ligandgi_frizzled
11.76Consensusgi_frizzledOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
11.63Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
11.43Single5DSGTiotropium5DSG-M4-Tiotropium
11.43Single5TGZAM65385TGZ-CB1-AM6538
11.43Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
11.43Single6GPSMK08126GPS-CCR2-MK0812
11.43Single6IIVDaltroban6IIV-TP-Daltroban
11.43Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/&β;1/&γ;2
11.43Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
11.43Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
11.43Consensusffa1_onOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.43Consensushcar_offOrthosteric Ligandsuccinate_off
11.43Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
11.43Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
11.43Consensustp_offOrthosteric Ligand6IIV-TP-Daltroban 6IIU-TP-Ramatroban
11.11Single4WW3All-trans-retinal4WW3-Rhodopsin-All-trans-retinal
11.11Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
11.11Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
11.11Single6GPXMK08126GPX-CCR2-MK0812
11.11Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
11.11Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
11.11Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
11.11Single8GDAL9026888GDA-EP4-L902688-Gs/&β;1/&γ;2
11.11Single8GDCPGE28GDC-EP3-PGE2-Gi1/&β;1/&γ;2
11.11Consensusep3_onOrthosteric Ligand8GDC-EP3-PGE2-Gi1/&β;1/&γ;2
11.11Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
11.11Consensusep_offOrthosteric Ligandep4_off
11.11Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
11.11Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
10.87Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
10.81Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
10.81Single8X79MRE-2698X79-I2-MRE-269-Gs/&β;1/&γ;2
10.81Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
10.81Consensusmglu2_onOther Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
10.81Consensuss1p2_onOrthosteric Ligand7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
10.53Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
10.53Single6IIURamatroban6IIU-TP-Ramatroban
10.53Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
10.53Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
10.53Consensusep_onOrthosteric Ligandep4_on ep2_on ep3_on
10.53Consensusprostanoid_onOrthosteric Ligandep_on fpa_on
10.42Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
10.34Single5MZPCaffeine5MZP-A2A-Caffeine-Na
10.34Single8WCCCyclohexylammonium ion8WCC-TA1-Cyclohexylammonium ion
10.26Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
10.26Consensusfpa_onOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.00Single7WC4Serotonin7WC4-5-HT2A-Serotonin
10.00Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.00Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.00Consensusclass-c_onOther Ligandgabab_on mglu_on
10.00Consensusgabab_offOther Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
9.76Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
9.76Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
9.68Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
9.68Single7MTBAll-trans-retinal7MTB-Rhodopsin-All-trans-retinal-GRK1
9.68Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/&β;1/&γ;2
9.68Single8IWM2-Phenylethylamine8IWM-TAAR9-2-Phenylethylamine
9.68Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/&β;1/&γ;2
9.68Single8WC5Tetramethylammonium ion8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2
9.68Consensussensory_onOrthosteric Ligandopsin_on
9.38Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
9.38Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
9.38Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
9.38Single6LI0GTPL98046LI0-GPR52-GTPL9804
9.38Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
9.38Single7MT8All-trans-retinal7MT8-Rhodopsin-All-trans-retinal-GRK1
9.38Single7MT9All-trans-retinal7MT9-Rhodopsin-All-trans-retinal-GRK1
9.38Single7MTAAll-trans-retinal7MTA-Rhodopsin-All-trans-retinal-GRK1
9.38Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
9.38Single8IW72-Phenylethylamine8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
9.38Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/&β;1/&γ;2
9.38Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/&β;1/&γ;2
9.38Consensusopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
9.09Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
9.09Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
9.09Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
9.09Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
9.09Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
9.09Single8ITFDMCHA8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
9.09Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
9.09Consensusgo_adhesionOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
9.09Consensusgo_class-b2Orthosteric Ligandgo_adhesion
8.93Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
8.82Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
8.82Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
8.82Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
8.82Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
8.82Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
8.82Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
8.82Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
8.82Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
8.57Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
8.57Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
8.57Single7VODCariprazine7VOD-5-HT2A-Cariprazine
8.57Single7VVOPTH7VVO-PTH1-PTH-Gs/&β;1/&γ;2
8.57Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
8.57Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
8.57Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
8.57Single8K2WAMG4878K2W-CXCR3-AMG487
8.57Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.57Consensussensory_offOrthosteric Ligandopsin_off
8.33Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
8.33Single7F83PF-051904577F83-Ghrelin-PF-05190457
8.33Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
8.33Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
8.16Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
8.11Single5CGCHTL142425CGC-mGlu5-HTL14242
8.11Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
8.11Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
8.11Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
8.11Consensusccr2_off_alloOther Ligand5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
8.00Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
7.89Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
7.89Single7P2L4YI7P2L-mGlu5-4YI
7.89Single8GDBPGE28GDB-EP4-PGE2-Gs/&β;1/&γ;2
7.89Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.84Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
7.69Single5X33BIIL2605X33-BLT1-BIIL260
7.69Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1
7.69Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
7.69Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
7.50Single5CGDHTL142425CGD-mGlu5-HTL14242
7.50Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2
7.50Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.50Consensusep2_onOrthosteric Ligand7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
7.41Single8F2APramlintide analogue san3858F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
7.14Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
7.14Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
7.02Single8F2BPramlintide analogue san458F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
6.78Single8F0JPramlintide analogue san458F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2
6.67Single8WCBCyclohexylammonium ion8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.45Single3PXOAll-trans-retinal3PXO-Rhodopsin-All-trans-retinal
6.45Single5DYSAll-trans-retinal5DYS-Rhodopsin-All-trans-retinal
6.45Single7XKEBetahydroxyandrosterone7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
6.45Single8HSCFab0468HSC-GPR20-Fab046-Gi1/&β;1/&γ;2
6.25Single2HPYAll-trans-retinal2HPY-Rhodopsin-All-trans-retinal
6.25Single6OY9All-trans-retinal6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
6.25Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
6.25Single7XKDBetahydroxyandrosterone7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
6.25Single7Y14Beta-alanine7Y14-MRGPRD-Beta-alanine
6.12Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
6.06Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
6.06Single3PQRAll-trans-retinal3PQR-Rhodopsin-All-trans-retinal-Gt(CT)
6.06Single7Y12Beta-alanine7Y12-MRGPRD-Beta-alanine-Gi1/&β;1/&γ;2
6.06Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
6.06Consensusadgrg3_onOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
6.00Single7TYLAmylin7TYL-CT-Amylin-Gs/&β;1/&γ;2
6.00Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/&β;1/&γ;2; RAMP2
5.88Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
5.88Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
5.88Single2G87All-trans-retinal2G87-Rhodopsin-All-trans-retinal
5.88Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
5.88Single3AYMAll-trans-retinal3AYM-Rhodopsin-All-trans-retinal
5.88Single8X2K5YM8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
5.77Single8F0KPramlintide analogue san3858F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
5.71Single8A6CAll-trans-retinal8A6C-Rhodopsin-All-trans-retinal
5.71Single8A6DAll-trans-retinal8A6D-Rhodopsin-All-trans-retinal
5.71Single8A6EAll-trans-retinal8A6E-Rhodopsin-All-trans-retinal
5.71Single8U8FPML8U8F-GPR3-PML-Gs/&β;1/&γ;2
5.71Consensusopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
5.71Consensussmo_on_alloOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
5.66Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
5.56Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
5.13Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
4.88Single7CX2PGE27CX2-EP2-PGE2-Gs/&β;1/&γ;2
4.55Single7SHEPI; PE7SHE-GPR158-PI; PE
3.92Single7TYIAmylin7TYI-CT-Amylin-Gs/&β;1/&γ;2
3.57Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
3.57Single6D35Cholesterol6D35-SMO-Cholesterol
3.57Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
3.57Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
3.57Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
3.57Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
3.57Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
3.57Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
3.57Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
3.57Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-PubChem 7023848
3.57Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
3.57Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626-Phospholipid
3.57Single7DD5Ca37DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
3.57Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
3.57Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
3.57Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
3.57Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
3.57Single7DTTCa7DTT-CaS-Ca-Ca
3.57Single7DTTCa7DTT-CaS-Ca-Ca
3.57Single7DTUTryptophan7DTU-CaS-Tryptophan
3.57Single7DTUTryptophan7DTU-CaS-Tryptophan
3.57Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
3.57Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
3.57Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
3.57Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
3.57Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.57Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.57Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.57Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.57Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
3.57Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
3.57Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
3.57Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
3.57Single7EB2Baclofen7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
3.57Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
3.57Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
3.57Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
3.57Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
3.57Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
3.57Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
3.57Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
3.57Single7FIIhCG7FII-LH-hCG-6fuf
3.57Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
3.57Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
3.57Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
3.57Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
3.57Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
3.57Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
3.57Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
3.57Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
3.57Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
3.57Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
3.57Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
3.57Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
3.57Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
3.57Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
3.57Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
3.57Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
3.57Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
3.57Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
3.57Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.57Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.57Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.57Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.57Single7T9NM22 Fab7T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
3.57Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
3.57Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
3.57Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
3.57Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
3.57Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
3.57Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
3.57Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
3.57Single7XW7K1-707XW7-TSH-K1-70
3.57Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
3.57Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
3.57Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
3.57Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
3.57Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
3.57Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
3.57Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
3.57Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
3.57Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
3.57Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
3.57Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
3.57Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
3.57Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-J9R
3.57Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
3.57Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
3.57Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
3.57Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
3.57Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
3.57Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
3.57Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
3.57Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
3.57Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
3.57Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
3.57Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
3.57Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
3.57Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
3.57Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
3.57Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
3.57Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
3.57Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
3.57Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
3.57Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
3.57Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
3.57Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
3.57Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
3.57Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
3.57Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
3.57Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
3.57Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
3.57Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
3.57Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
3.57Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
3.57Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.57Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.57Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.57Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.57Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.57Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.57Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
3.57Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
3.57Consensusclass-c_offOrthosteric Ligandgabab_off mglu_off
3.57Consensusclass-c_offOrthosteric Ligandgabab_off mglu_off
3.57Consensusclass-c_offOther Ligandgabab_off mglu_off
3.57Consensusclass-c_onOrthosteric Ligandgabab_on mglu_on
3.57Consensusclass-c_onOrthosteric Ligandgabab_on mglu_on
3.57Consensusfsh_on_alloOrthosteric Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
3.57Consensusgabab_offOrthosteric Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
3.57Consensusgabab_onOrthosteric Ligand7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
3.57Consensusgi_class-cOrthosteric Ligandgi_mglu gi_gaba
3.57Consensusgi_class-cOrthosteric Ligandgi_mglu gi_gaba
3.57Consensusgi_gabaOrthosteric Ligand7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
3.57Consensusgi_mgluOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
3.57Consensusgi_mgluOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
3.57Consensusgphr_onOrthosteric Ligandlh_on tsh_on
3.57Consensusgs_gphrOrthosteric Ligand7T9I-TSH-TSH-Gs/&β;1/&γ;2 7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
3.57Consensusgs_proteinOrthosteric Ligandgs_gphr
3.57Consensuslh_onOrthosteric Ligand7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
3.57Consensuslh_on_alloOrthosteric Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
3.57Consensusmglu2_offOrthosteric Ligand7MTQ-mGlu2; mGlu2-LY341495
3.57Consensusmglu2_offOrthosteric Ligand7MTQ-mGlu2; mGlu2-LY341495
3.57Consensusmglu2_onOrthosteric Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
3.57Consensusmglu2_onOrthosteric Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
3.57Consensusmglu3_offOrthosteric Ligand7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
3.57Consensusmglu3_offOrthosteric Ligand7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
3.57Consensusmglu4_onOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
3.57Consensusmglu4_onOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
3.57Consensusmglu5_offOrthosteric Ligand7FD9-mGlu5; mGlu5-LY341495
3.57Consensusmglu5_offOrthosteric Ligand7FD9-mGlu5; mGlu5-LY341495
3.57Consensusmglu_offOrthosteric Ligandmglu2_off mglu3_off mglu5_off
3.57Consensusmglu_offOrthosteric Ligandmglu2_off mglu3_off mglu5_off
3.57Consensusmglu_onOrthosteric Ligandmglu2_on mglu4_on
3.57Consensusmglu_onOrthosteric Ligandmglu2_on mglu4_on
3.57Consensussmo_off_alloOther Ligand6D32-SMO-Cyclopamine-Cyclopamine
3.57Consensustsh_onOrthosteric Ligand7T9I-TSH-TSH-Gs/&β;1/&γ;2
3.57Consensustsh_on_alloOrthosteric Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
3.45Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
3.45Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
3.45Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
3.45Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
3.45Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
3.45Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
3.45Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
3.45Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
3.45Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
3.45Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
3.33Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
3.33Single7T9MCS-17 Antibody7T9M-TSH-CS-17 Antibody
3.33Single8HS2Fab0468HS2-GPR20-Fab046
3.23Single4A4MAll-trans-retinal4A4M-Rhodopsin-All-trans-retinal-Gt(CT)
3.23Single5EN0All-trans-retinal5EN0-Rhodopsin-All-trans-retinal-Gt(CT)
3.23Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
3.23Single6W25Ca6W25-MC4-SHU9119-Ca
3.23Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
3.23Single7UTZTR14027UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
3.23Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
3.23Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
3.23Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
3.23Consensusccr8_offOrthosteric Ligand8TLM-CCR8-Anti-murine CCR8 antibody
3.12Single5L7DCholesterol5L7D-SMO-Cholesterol
3.12Single7T9ITSH7T9I-TSH-TSH-Gs/&β;1/&γ;2
3.12Single8I2GGlycoprotein hormones alpha chain8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
3.12Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
2.94Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
2.94Consensusgip_on_alloOther Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
2.86Single7XKFBetahydroxyandrosterone7XKF-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
2.86Single8J6QCompound 9n8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
2.86Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
2.86Consensushca2_on_alloOther Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
2.78Single8G94CD698G94-S1P1-CD69-Gi1/&β;1/&γ;2
2.78Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
2.78Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2
2.70Single6FFIMMPEP6FFI-mGlu5-MMPEP
2.70Single8IYXYL-3658IYX-GPR34-YL-365
2.70Single8JD6N-(3-chlorophenyl)pyridine-2-carboxamide8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
2.63Single6FFHFenobam6FFH-mGlu5-Fenobam
2.50Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
2.50Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
2.44Single7SHEPI; PE7SHE-GPR158-PI; PE
2.44Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
2.38Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
2.38Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
2.22Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7

Consensus Members
Id Members
npy2_on 7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
npy4_on 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
npy1_on 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
Net Summary
Imin 3.035
Number of Linked Nodes 269
Number of Links 317
Number of Hubs 33
Number of Links mediated by Hubs 164
Number of Communities 5
Number of Nodes involved in Communities 62
Number of Links involved in Communities 94
Path Summary
Number Of Nodes in MetaPath 59
Number Of Links MetaPath 58
Number of Shortest Paths 44281
Length Of Smallest Path 3
Average Path Length 11.3072
Length of Longest Path 28
Minimum Path Strength 0.381667
Average Path Strength 5.66686
Maximum Path Strength 35.7875
Minimum Path Correlation 0.7
Average Path Correlation 0.934298
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 4.54545
Average % Of Corr. Nodes 61.2186
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 47.0705
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following differences:
Id1st Network2nd Network
npy_off_onnpy_offnpy_on
This network is also present in following consensuses:
IdComponents
peptide_onopioid_on
angiotensin_on
bombesin_on
cck_on
endothelin_on
ghrelin_on
npy_on
nts_on
orexin_on
vasopressin-ot_on
tachykinin_on
sst_on
relaxin_on
trh_on
nmur_on
motilin_on
melanocortin_on
galanin_on
fpr-alx_on
compl-peptide_on
bradykinin_on
apelin_on



You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download npy_on.zip



You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.



You can also  read or  download a guide explaining the meaning of all files and numerical data.