Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:F70 4.2125417
2R:R:M81 3.09407
3R:R:I96 3.034505
4R:R:Y97 6.522507
5R:R:N100 9.602529
6R:R:T111 4.215417
7R:R:M112 7.902517
8R:R:W124 9.60167618
9R:R:F126 11.062507
10R:R:Y140 7.2475405
11R:R:T144 7.08427
12R:R:F147 4.205406
13R:R:R156 6.68167649
14R:R:Y157 6.876507
15R:R:W183 9.795429
16R:R:V189 4.3675405
17R:R:F214 6.828506
18R:R:W222 8.56467
19R:R:K227 7.38404
20R:R:F235 7.4275408
21R:R:Y246 8.7825408
22R:R:F283 9.378519
23R:R:W287 7.42375818
24R:R:I316 6.96415
25R:R:Y320 10.5725416
26R:R:N322 7.86419
27R:R:N326 6.8425409
28R:R:Y330 7.1775409
29R:R:E335 5.865404
30R:R:F337 7.30667638
31L:L:?1 9.202311310
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:M112 R:R:V69 24.4824.56YesNo077
2R:R:V65 R:R:V69 11.82191.6NoNo057
3R:R:I61 R:R:V65 10.37311.54NoNo055
4R:R:S324 R:R:V69 11.82198.08NoNo077
5R:R:D105 R:R:N326 12.90016.73NoYes099
6R:R:N322 R:R:N326 40.33449.54YesYes099
7R:R:N322 R:R:W287 36.00916.78YesYes198
8L:L:?1 R:R:W287 79.69175.91YesYes108
9L:L:?1 R:R:Y320 33.023113.7YesYes106
10R:R:M112 R:R:Y320 33.772717.96YesYes176
11R:R:F337 R:R:F341 17.83619.65YesNo086
12R:R:F337 R:R:I98 34.71613.77YesNo088
13R:R:I98 R:R:Y330 35.069912.09NoYes089
14R:R:N326 R:R:Y330 33.81498.14YesYes099
15R:R:F341 R:R:L79 14.94696.09NoNo066
16R:R:F344 R:R:L79 13.48974.87NoNo046
17R:R:L103 R:R:W183 10.96284.56NoYes069
18R:R:N100 R:R:W183 26.655210.17YesYes299
19R:R:I182 R:R:N100 97.60784.25NoYes279
20R:R:F147 R:R:I182 1007.54YesNo067
21R:R:F143 R:R:F147 41.61894.29NoYes066
22R:R:F143 R:R:V189 41.23159.18NoYes065
23R:R:V189 R:R:Y139 42.77295.05YesNo055
24L:L:?1 R:R:Y139 43.24886.09YesNo005
25R:R:F147 R:R:I146 62.83273.77YesNo067
26R:R:F283 R:R:I146 66.51797.54YesNo097
27R:R:F283 R:R:W287 61.173422.05YesYes198
28R:R:F337 R:R:I84 22.65413.77YesNo087
29R:R:N179 R:R:Y97 67.93724.65NoYes077
30R:R:N100 R:R:N179 77.952320.43YesNo097
31R:R:M152 R:R:Y97 65.06915.99NoYes087
32R:R:M152 R:R:V276 63.22026.09NoNo088
33R:R:R156 R:R:V276 22.56156.54YesNo098
34R:R:A175 R:R:I96 10.84064.87NoYes075
35R:R:I96 R:R:N179 27.27854.25YesNo057
36R:R:A175 R:R:Y97 10.75646.67NoYes077
37L:L:?1 R:R:I316 16.72424.63YesYes105
38R:R:I316 R:R:Y312 23.231113.3YesNo054
39R:R:M121 R:R:P125 46.54236.71NoNo041
40R:R:F126 R:R:P125 49.048213YesNo071
41R:R:S123 R:R:V207 21.021.62NoNo043
42R:R:M121 R:R:S123 44.0283.07NoNo044
43L:L:?1 R:R:V134 34.0173.87YesNo006
44R:R:V134 R:R:W124 32.90097.36NoYes068
45L:L:?1 R:R:C210 35.41954.12YesNo109
46R:R:C210 R:R:W124 32.989423.51NoYes198
47R:R:D128 R:R:T199 13.19915.78NoNo024
48R:R:I208 R:R:T199 15.81454.56NoNo044
49R:R:I208 R:R:S123 21.023.1NoNo044
50R:R:W183 R:R:Y140 14.5518.68YesYes095
51R:R:H291 R:R:W287 16.4214.23NoYes188
52R:R:S153 R:R:Y246 10.503710.17NoYes098
53R:R:V276 R:R:Y246 40.6253.79NoYes088
54R:R:M249 R:R:Y157 24.8613.59NoYes087
55R:R:M249 R:R:Y246 26.87843.59NoYes088
56R:R:R252 R:R:Y157 10.503718.52NoYes057
57R:R:I96 R:R:P172 11.89771.69YesNo052
58R:R:F214 R:R:Y219 21.891812.38YesNo061
59R:R:D223 R:R:Y219 26.048712.64NoNo041
60R:R:D223 R:R:K227 28.175516.59NoYes044
61R:R:I294 R:R:K227 38.68777.27NoYes054
62L:L:?1 R:R:I294 28.141810.19YesNo005
63R:R:R202 R:R:V205 13.19913.92NoNo021
64R:R:V205 R:R:V207 15.81456.41NoNo013
65R:R:F214 R:R:W222 13.2377.02YesYes067
66R:R:F235 R:R:H291 21.828715.84YesNo088
67R:R:D266 R:R:L269 10.36895.43NoNo036
68R:R:L269 R:R:R156 12.29782.43NoYes069
69R:R:E335 R:R:N336 10.34796.57YesNo046
70R:R:D334 R:R:N336 11.82198.08NoNo086
71R:R:D334 R:R:F337 17.625511.94NoYes088
72R:R:I290 R:R:W287 19.95874.7NoYes068
73R:R:I290 R:R:I294 13.34654.42NoNo065
74R:R:F293 R:R:Y312 11.67457.22NoNo054
75R:R:I84 R:R:K91 22.17821.45NoNo077
76R:R:F126 R:R:W124 58.562215.03YesYes078
77R:R:I96 R:R:K91 21.31911.45YesNo057
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:I137 R:R:T111 4.56 0 No Yes 5 7 2 1
R:R:T111 R:R:Y320 4.99 1 Yes Yes 7 6 1 1
L:L:?1 R:R:T111 5.74 1 Yes Yes 0 7 0 1
R:R:M112 R:R:Y320 17.96 1 Yes Yes 7 6 2 1
R:R:I316 R:R:Q115 5.49 1 Yes No 5 7 1 1
R:R:Q115 R:R:Y320 5.64 1 No Yes 7 6 1 1
L:L:?1 R:R:Q115 9.5 1 Yes No 0 7 0 1
R:R:C131 R:R:W124 5.22 1 No Yes 9 8 2 2
R:R:V134 R:R:W124 7.36 0 No Yes 6 8 1 2
R:R:C210 R:R:W124 23.51 1 No Yes 9 8 1 2
R:R:C131 R:R:C210 7.28 1 No No 9 9 2 1
L:L:?1 R:R:V134 3.87 1 Yes No 0 6 0 1
L:L:?1 R:R:D138 33.47 1 Yes No 0 6 0 1
R:R:V189 R:R:Y139 5.05 0 Yes No 5 5 2 1
L:L:?1 R:R:Y139 6.09 1 Yes No 0 5 0 1
R:R:N141 R:R:W287 4.52 0 No Yes 8 8 2 1
R:R:M142 R:R:W287 6.98 1 No Yes 7 8 1 1
R:R:H291 R:R:M142 5.25 1 No No 8 7 2 1
L:L:?1 R:R:M142 11.01 1 Yes No 0 7 0 1
L:L:?1 R:R:C210 4.12 1 Yes No 0 9 0 1
R:R:I294 R:R:K227 7.27 0 No Yes 5 4 1 2
L:L:?1 R:R:V230 8.7 1 Yes No 0 5 0 1
R:R:F283 R:R:W287 22.05 1 Yes Yes 9 8 2 1
R:R:F283 R:R:N322 7.25 1 Yes Yes 9 9 2 2
R:R:I290 R:R:W287 4.7 0 No Yes 6 8 2 1
R:R:H291 R:R:W287 4.23 1 No Yes 8 8 2 1
R:R:G319 R:R:W287 4.22 0 No Yes 7 8 2 1
R:R:N322 R:R:W287 6.78 1 Yes Yes 9 8 2 1
L:L:?1 R:R:W287 5.91 1 Yes Yes 0 8 0 1
R:R:I290 R:R:I294 4.42 0 No No 6 5 2 1
R:R:I290 R:R:I316 4.42 0 No Yes 6 5 2 1
L:L:?1 R:R:I294 10.19 1 Yes No 0 5 0 1
R:R:I316 R:R:Y312 13.3 1 Yes No 5 4 1 2
L:L:?1 R:R:I316 4.63 1 Yes Yes 0 5 0 1
L:L:?1 R:R:Y320 13.7 1 Yes Yes 0 6 0 1
L:L:?1 R:R:L135 2.7 1 Yes No 0 4 0 1
R:R:T110 R:R:T111 1.57 0 No Yes 4 7 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
71.43Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
69.23Single6B73PubChem 1319551386B73-κ-PubChem 131955138
69.23Single8EFOPZM218EFO-μ-PZM21-Gi1/&β;1/&γ;2
66.67Single7SBFPZM217SBF-μ-PZM21-Gi1/&β;1/&γ;2
66.67Single8DZQmomSalB8DZQ-κ-momSalB-Go/&β;1/&γ;2
66.67Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
66.67Consensusgo_opioidOrthosteric Ligand8DZQ-κ-momSalB-Go/&β;1/&γ;2
64.71Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/&β;1/&γ;2
64.29Single6VI4JDTic6VI4-κ-JDTic
62.50Single8DZPmomSalB8DZP-κ-momSalB-Gi1/&β;1/&γ;2
62.50Consensusdopamine_offOrthosteric Ligandd3_off d2_off d4_off
60.00Single7SCGFH2107SCG-μ-FH210-Gi1/&β;1/&γ;2
58.82Single7YITNalfurafine7YIT-κ-Nalfurafine
58.82Consensusopioid_offOrthosteric Ligandkop_off mop_off nop_off dop_off
57.89Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
56.25Single6TP6Filorexant6TP6-OX1-Filorexant
56.25Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
55.56Single6DDFDamgo6DDF-μ-Damgo-Gi1/&β;1/&γ;2
55.56Consensusendothelin_offOrthosteric Ligandetb_off
55.56Consensusetb_offOrthosteric Ligand5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500 5X93-ETB-K-8794
55.00Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
55.00Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
53.33Single4ZJCSB-6740424ZJC-OX1-SB-674042
53.33Single6TPGEMPA6TPG-OX2-EMPA
53.33Single6ZG9GSK10347026ZG9-M1-GSK1034702
53.33Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
53.33Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
53.33Consensusox1_offOrthosteric Ligand6TOT-OX1-Lemborexant 6TP4-OX1-ACT-462206 6TP6-OX1-Filorexant 6V9S-OX1-GTPL11403 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ7-OX1-SB-334867 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant
53.33Consensusox2_offOrthosteric Ligand6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant
52.94Single5X93K-87945X93-ETB-K-8794
52.94Single6H7JIsoprenaline6H7J-β1-Isoprenaline
52.94Single6TQ7SB-3348676TQ7-OX1-SB-334867
52.94Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2
52.94Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
52.94Single8E0GBU728E0G-μ-BU72
52.94Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
52.94Single8EFLSR170188EFL-μ-SR17018-Gi1/&β;1/&γ;2
52.94Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
52.63Single8X5YAstemizole8X5Y-H1-Astemizole
50.00Single2Y04Salbutamol2Y04-β1-Salbutamol
50.00Single3NY8ICI 118-5513NY8-β2-ICI 118-551
50.00Single4AMIBucindolol4AMI-β1-Bucindolol
50.00Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
50.00Single4EJ4Naltrindole4EJ4-δ-Naltrindole
50.00Single4GBR(S)-Carazolol4GBR-β2-(S)-Carazolol
50.00Single4LDEBI1671074LDE-β2-BI167107
50.00Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
50.00Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
50.00Single6PS0(S)-Carazolol6PS0-β2-(S)-Carazolol
50.00Single6TOTLemborexant6TOT-OX1-Lemborexant
50.00Single7DFPSpiperone7DFP-D2-Spiperone
50.00Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
50.00Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
50.00Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
50.00Single7UL4Alvimopan7UL4-μ-Alvimopan
50.00Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
50.00Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
50.00Consensusalpha2_onOrthosteric Ligandalpha2a_on alpha2b_on
50.00Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
50.00Consensusat2_offOrthosteric Ligand7JNI-AT2-Olodanrigan
50.00Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
50.00Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
47.62Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
47.37Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
47.37Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
47.37Single6K1QIRL25006K1Q-ETB-IRL2500
47.37Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
47.37Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/&β;1/&γ;2
47.37Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
47.06Single2RH1(S)-Carazolol2RH1-β2-(S)-Carazolol
47.06Single2Y03Isoprenaline2Y03-β1-Isoprenaline
47.06Single2YCW(S)-Carazolol2YCW-β1-(S)-Carazolol
47.06Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
47.06Single5C1MBU725C1M-μ-BU72
47.06Single5D6L(S)-Carazolol5D6L-β2-(S)-Carazolol
47.06Single5WQCEMPA5WQC-OX2-EMPA
47.06Single5X7D(S)-Carazolol5X7D-β2-(S)-Carazolol-PubChem 129318963
47.06Single5XPRBosentan5XPR-ETB-Bosentan
47.06Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
47.06Single6PS3(S)-Carvedilol6PS3-β2-(S)-Carvedilol
47.06Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
47.06Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
47.06Single7BVQ(S)-Carazolol7BVQ-β1-(S)-Carazolol
47.06Single7C4SS1P7C4S-S1P3-S1P
47.06Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2
47.06Single7WC6LSD7WC6-5-HT2A-LSD
47.06Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
47.06Consensusadrenergic_offOrthosteric Ligandbeta_off alpha_off
47.06Consensusalpha2a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
47.06Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
47.06Consensusamine_offOrthosteric Ligandadrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
47.06Consensusbeta2_offOrthosteric Ligand6PS2-β2-(S)-Alprenolol 6PS3-β2-(S)-Carvedilol 6PS5-β2-(S)-Propranolol 6PS6-β2-Timolol 2RH1-β2-(S)-Carazolol 6PS4-β2-ICI 118-551 3NY9-β2-PubChem 913103
47.06Consensusbeta2_onOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
47.06Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
47.06Consensusgi_adrenergicOrthosteric Ligand7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
47.06Consensusgo_amineOrthosteric Ligandgo_adrenergic go_muscarinic go_5ht
46.67Single5DHHSB-6121115DHH-NOP-SB-612111
46.67Single5WS3EMPA5WS3-OX2-EMPA
46.67Single6AKXA4R6AKX-CCR5-A4R
46.67Single6TODEMPA6TOD-OX1-EMPA-Na
46.67Single8IHKAcifran8IHK-HCA3-Acifran
46.67Single8UO0Epinephrine8UO0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
46.67Consensusalpha1_onOrthosteric Ligandalpha1a_on
46.67Consensusalpha1a_onOrthosteric Ligand7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
46.67Consensusorexin_offOrthosteric Ligandox2_off ox1_off
45.83Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
45.45Single6PT2KGCHM076PT2-δ-KGCHM07
45.00Single5ZTYAM102575ZTY-CB2-AM10257
45.00Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
45.00Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
45.00Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
45.00Consensuslpl_offOrthosteric Ligands1p_off lpa_off
44.44Single2YDVNECA2YDV-A2A-NECA
44.44Single3SN6BI1671073SN6-β2-BI167107-Gs/&β;1/&γ;2
44.44Single4RWADIPP-NH24RWA-δ-DIPP-NH2
44.44Single4UHRCGS216804UHR-A2A-CGS21680
44.44Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
44.44Single5D5A(S)-Carazolol5D5A-β2-(S)-Carazolol
44.44Single5D5B(S)-Carazolol5D5B-β2-(S)-Carazolol
44.44Single5G53NECA5G53-A2A-NECA-Gs
44.44Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
44.44Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
44.44Single7CKYPW04647CKY-D1-PW0464-Gs/&β;1/&γ;2
44.44Single7EW7PubChem 40774607EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
44.44Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
44.44Single7W6PW967W6P-α2a-W96-Go/&β;1/&γ;2
44.44Single7W7EW587W7E-α2a-W58-Go/&β;1/&γ;2
44.44Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/&β;1/&γ;2
44.44Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
44.44Consensus5ht_offOrthosteric Ligand5ht2_off 5ht5_off 5ht1_off
44.44Consensusangiotensin_offOrthosteric Ligandat1_off at2_off
44.44Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCZ-β1-Iodocyanopindolol
44.44Consensusgi_amineOrthosteric Ligandgi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
44.44Consensusgo_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
44.44Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2
44.44Consensush1_offOrthosteric Ligand3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole 8X63-H1-Mepyramine 8X64-H1-Desloratadine
44.44Consensushistamine_offOrthosteric Ligandh1_off
44.44Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
43.75Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
43.75Single4DKLBeta-funaltrexamine4DKL-μ-Beta-funaltrexamine
43.75Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
43.75Single4MBSMaraviroc4MBS-CCR5-Maraviroc
43.75Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
43.75Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
43.75Single6PS4ICI 118-5516PS4-β2-ICI 118-551
43.75Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
43.75Single6TP3Nemorexant6TP3-OX1-Nemorexant
43.75Single6TPNHTL66416TPN-OX2-HTL6641
43.75Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
43.75Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
43.75Single7CMVPD1289077CMV-D3-PD128907-Gi1/&β;1/&γ;2
43.75Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
43.75Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
43.75Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
43.75Single8GEGEpinephrine8GEG-β2-Epinephrine-Gs/&β;1/&γ;2
43.75Single8GGQEpinephrine8GGQ-β2-Epinephrine
43.75Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
43.75Single8UNZEpinephrine8UNZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
43.75Single8UO2Epinephrine8UO2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
43.75Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
43.75Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
43.75Consensus5ht5_onOrthosteric Ligand5ht5a_on
43.75Consensus5ht5a_onOrthosteric Ligand7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
43.75Consensusalpha2b_onOrthosteric Ligand6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
43.75Consensusd3_onOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
43.75Consensusdop_off_alloOrthosteric Ligand4N6H-δ-Naltrindole-Na
43.75Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
43.75Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
43.75Consensuss1p_offOrthosteric Ligands1p1_off
43.48Single7C61Ergotamine7C61-5-HT1B-Ergotamine
42.86Single4AMJ(S)-Carvedilol4AMJ-β1-(S)-Carvedilol
42.86Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
42.86Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
42.86Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
42.86Consensusmop_offOrthosteric Ligand7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
42.11Single3D4STimolol Maleate3D4S-β2-Timolol Maleate
42.11Single6H7N(S)-Xamoterol6H7N-β1-(S)-Xamoterol
42.11Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
42.11Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
42.11Single6ZG4HTL00099366ZG4-M1-HTL0009936
42.11Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
42.11Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
42.11Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
42.11Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
42.11Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
42.11Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
42.11Single8JJ8Formoterol8JJ8-β2-Formoterol
42.11Consensusgo_5htOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
42.11Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
42.11Consensusleuko_offOrthosteric Ligandblt_off cyslt_off
42.11Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
42.11Consensuspeptide_offOrthosteric Ligandopioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
41.18Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
41.18Single3NYA(S)-Alprenolol3NYA-β2-(S)-Alprenolol
41.18Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
41.18Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
41.18Single4QKXPubChem 762106284QKX-β2-PubChem 76210628
41.18Single5DHGPubChem 250014125DHG-NOP-PubChem 25001412
41.18Single5JQH(S)-Carazolol5JQH-β2-(S)-Carazolol
41.18Single6H7MSalbutamol6H7M-β1-Salbutamol
41.18Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
41.18Single6PRZ(S)-Alprenolol6PRZ-β2-(S)-Alprenolol
41.18Single6PS2(S)-Alprenolol6PS2-β2-(S)-Alprenolol
41.18Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
41.18Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
41.18Single7BU7BI1671077BU7-β1-BI167107
41.18Single7CRHSKF839597CRH-D1-SKF83959-Gs/&β;1/&γ;2
41.18Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
41.18Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
41.18Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
41.18Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/&β;1/&γ;2
41.18Single7T2GMitragynine pseudoindoxyl7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
41.18Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
41.18Single7VKTLTB47VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
41.18Single7WC7Lisuride7WC7-5-HT2A-Lisuride
41.18Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
41.18Single8GE3Epinephrine8GE3-β2-Epinephrine-Gs/&β;1/&γ;2
41.18Single8GEEEpinephrine8GEE-β2-Epinephrine-Gs/&β;1/&γ;2
41.18Single8GEHEpinephrine8GEH-β2-Epinephrine-Gs/&β;1/&γ;2
41.18Single8GFWEpinephrine8GFW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
41.18Single8GFXEpinephrine8GFX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
41.18Single8GFYEpinephrine8GFY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
41.18Single8GFZEpinephrine8GFZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
41.18Single8GG0Epinephrine8GG0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
41.18Single8GG1Epinephrine8GG1-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
41.18Single8GG2Epinephrine8GG2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
41.18Single8GG6Epinephrine8GG6-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
41.18Single8GGJEpinephrine8GGJ-β2-Epinephrine
41.18Single8GGNEpinephrine8GGN-β2-Epinephrine
41.18Single8GGOEpinephrine8GGO-β2-Epinephrine
41.18Single8GGUEpinephrine8GGU-β2-Epinephrine
41.18Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2
41.18Single8JJOAlprenolol8JJO-β2-Alprenolol
41.18Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
41.18Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
41.18Single8UNNEpinephrine8UNN-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
41.18Single8UNPEpinephrine8UNP-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
41.18Single8UO4Epinephrine8UO4-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
41.18Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
41.18Single8X64Desloratadine8X64-H1-Desloratadine
41.18Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
41.18Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
41.18Consensusadrenergic_onOrthosteric Ligandbeta_on alpha_on
41.18Consensusamine_onOrthosteric Ligandadrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
41.18Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
41.18Consensusblt_onOrthosteric Ligandblt1_on
41.18Consensusdopamine_onOrthosteric Ligandd3_on d2_on d5_on d1_on
41.18Consensusgi_hcaOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
41.18Consensusgi_hcarOrthosteric Ligandgi_hca
41.18Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
41.18Consensushca2_onOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
41.18Consensushca3_onOrthosteric Ligand8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
41.18Consensusleuko_onOrthosteric Ligandblt_on
41.18Consensustar_onOrthosteric Ligandta1_on
40.91Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
40.91Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
40.74Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
40.74Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
40.00Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
40.00Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
40.00Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
40.00Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
40.00Single6H7LDobutamine6H7L-β1-Dobutamine
40.00Single6IBLArformoterol6IBL-β1-Arformoterol
40.00Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2
40.00Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
40.00Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
40.00Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
40.00Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
40.00Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
40.00Single7XJISolabegron7XJI-β3-Solabegron-Gs/&β;1/&γ;2
40.00Single7XK2MK68927XK2-HCA2-MK6892-Gi1/&β;1/&γ;2
40.00Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
40.00Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
40.00Single8E9YPubChem 4466038E9Y-M3-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
40.00Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
40.00Single8GAGYVF8GAG-CB1-YVF-Gi1/&β;1/&γ;2
40.00Single8GEIEpinephrine8GEI-β2-Epinephrine-Gs/&β;1/&γ;2
40.00Single8GGCEpinephrine8GGC-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
40.00Single8GGEEpinephrine8GGE-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
40.00Single8GH1Epinephrine8GH1-β2-Epinephrine
40.00Single8HN8Histamine8HN8-H4-Histamine-Gi1/&β;1/&γ;2
40.00Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
40.00Consensusbeta1_off_alloOrthosteric Ligand4BVN-β1-Cyanopindolol-Na
40.00Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
40.00Consensusgs_orexinOrthosteric Ligand7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
40.00Consensusorexin_onOrthosteric Ligandox2_on
40.00Consensusox1_off_alloOrthosteric Ligand6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na 6TO7-OX1-Suvorexant-Na
39.13Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
39.13Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
39.13Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
39.13Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
38.89Single5TVNLSD5TVN-5-HT2B-LSD
38.89Single5WIUNemonapride5WIU-D4-Nemonapride
38.89Single5WIVNemonapride5WIV-D4-Nemonapride-Na
38.89Single6DDEDamgo6DDE-μ-Damgo-Gi1/&β;1/&γ;2
38.89Single6E67BI1671076E67-β2-BI167107-Gs (fused)
38.89Single6PS6Timolol6PS6-β2-Timolol
38.89Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
38.89Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
38.89Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
38.89Single7XKAEpinephrine7XKA-β2-Epinephrine
38.89Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
38.89Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
38.89Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
38.89Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
38.89Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
38.89Single8UNYEpinephrine8UNY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
38.89Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
38.89Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
38.89Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
38.89Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
38.89Consensuscb2_onOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
38.89Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRR-D1-Rotigotine-Gs/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
38.89Consensusd4_offOrthosteric Ligand5WIU-D4-Nemonapride
38.89Consensusd4_off_alloOrthosteric Ligand5WIV-D4-Nemonapride-Na
38.89Consensusgs_adrenergicOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJI-β3-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
38.89Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
38.10Single3NY9PubChem 9131033NY9-β2-PubChem 913103
38.10Single4UG2CGS216804UG2-A2A-CGS21680
38.10Single6PT3DPI-2876PT3-δ-DPI-287
38.10Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
38.10Single7SK9CCX6627SK9-ACKR3-CCX662
38.10Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
38.10Single7XY6PubChem 117178317XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
38.10Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
38.10Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
38.10Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
38.10Consensuslpl_onOrthosteric Ligands1p_on lpa_on
38.10Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
37.50Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
37.50Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
37.50Single4S0VSuvorexant4S0V-OX2-Suvorexant
37.50Single6AKYMaraviroc6AKY-CCR5-Maraviroc
37.50Single6KUXRS-799486KUX-α2a-RS-79948
37.50Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
37.50Single6OBA(S)-Alprenolol6OBA-β2-(S)-Alprenolol-GTPL11074
37.50Single6TPJSuvorexant6TPJ-OX2-Suvorexant
37.50Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
37.50Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
37.50Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2
37.50Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2
37.50Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/&β;1/&γ;2
37.50Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
37.50Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
37.50Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
37.50Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
37.50Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
37.50Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
37.50Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
37.50Single7XRRLemborexant7XRR-OX2-Lemborexant
37.50Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
37.50Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
37.50Single8GECEpinephrine8GEC-β2-Epinephrine-Gs/&β;1/&γ;2
37.50Single8GEFEpinephrine8GEF-β2-Epinephrine-Gs/&β;1/&γ;2
37.50Single8GG9Epinephrine8GG9-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
37.50Single8GGAEpinephrine8GGA-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
37.50Single8GGFEpinephrine8GGF-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
37.50Single8GGVEpinephrine8GGV-β2-Epinephrine
37.50Single8GGWEpinephrine8GGW-β2-Epinephrine
37.50Single8GGXEpinephrine8GGX-β2-Epinephrine
37.50Single8GH0Epinephrine8GH0-β2-Epinephrine
37.50Single8HOCImetit8HOC-H4-Imetit-Gi1/&β;1/&γ;2
37.50Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
37.50Single8UNWEpinephrine8UNW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
37.50Single8UO3Epinephrine8UO3-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
37.50Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
37.50Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
37.50Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
37.50Consensusalpha2_offOrthosteric Ligandalpha2a_off alpha2c_off
37.50Consensusalpha2a_offOrthosteric Ligand6KUX-α2a-RS-79948
37.50Consensusbeta2_off_alloOrthosteric Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
37.50Consensusgi_histamineOrthosteric Ligand8HN8-H4-Histamine-Gi1/&β;1/&γ;2 8HOC-H4-Imetit-Gi1/&β;1/&γ;2
37.50Consensusgi_nucleotideOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
37.50Consensusgs_histamineOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
37.50Consensush4_onOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
37.50Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
37.04Single8FEGPRD_0025178FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
36.84Single3P0GBI1671073P0G-β2-BI167107
36.84Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
36.84Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
36.84Single4U15Tiotropium4U15-M3-Tiotropium
36.84Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
36.84Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
36.84Single6J21Aprepitant6J21-NK1-Aprepitant
36.84Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
36.84Single6NI3BI1671076NI3-β2-BI167107-Gs/&β;1/&γ;2
36.84Single6OL9Tiotropium6OL9-M5-Tiotropium
36.84Single6WGTLSD6WGT-5-HT2A-LSD
36.84Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2
36.84Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
36.84Single7FEEPubMed 1048957FEE-CB1-PubMed 104895-ZCZ011
36.84Single7JVPSKF839597JVP-D1-SKF83959-Gs/&β;1/&γ;2
36.84Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
36.84Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
36.84Single7WV9PubMed 1048957WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
36.84Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/&β;1/&γ;2
36.84Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2
36.84Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/&β;1/&γ;2
36.84Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
36.84Single8JXVClozapine8JXV-H4-Clozapine-Gi1/&β;1/&γ;2
36.84Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/&β;1/&γ;2
36.84Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
36.84Consensusa2_onOrthosteric Liganda2a_on a2b_on
36.84Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
36.84Consensusgi_dopamineOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
36.84Consensuslpa_offOrthosteric Ligandlpa1_off
36.84Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
36.84Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
36.84Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
36.36Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
36.36Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
36.36Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
36.00Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
35.71Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.71Single8WC5Tetramethylammonium ion8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2
35.29Single2YDOAdenosine2YDO-A2A-Adenosine
35.29Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
35.29Single6DS0Ly2660976DS0-5-HT2B-Ly266097
35.29Single6IQLL7458706IQL-D4-L745870
35.29Single6PS5(S)-Propranolol6PS5-β2-(S)-Propranolol
35.29Single6TPKRetosiban6TPK-OT-Retosiban
35.29Single6V9SGTPL114036V9S-OX1-GTPL11403
35.29Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
35.29Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
35.29Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2
35.29Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
35.29Single7F0TDopamine7F0T-D1-Dopamine-Gs/&β;1/&γ;2
35.29Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/&β;1/&γ;2
35.29Single7JOZVFP7JOZ-D1-VFP-Gs/&β;1/&γ;2
35.29Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
35.29Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2
35.29Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
35.29Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
35.29Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
35.29Single8GE1Epinephrine8GE1-β2-Epinephrine-Gs/&β;1/&γ;2
35.29Single8GE4Epinephrine8GE4-β2-Epinephrine-Gs/&β;1/&γ;2
35.29Single8GE6Epinephrine8GE6-β2-Epinephrine-Gs/&β;1/&γ;2
35.29Single8GE7Epinephrine8GE7-β2-Epinephrine-Gs/&β;1/&γ;2
35.29Single8GE8Epinephrine8GE8-β2-Epinephrine-Gs/&β;1/&γ;2
35.29Single8GE9Epinephrine8GE9-β2-Epinephrine-Gs/&β;1/&γ;2
35.29Single8GFVEpinephrine8GFV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.29Single8GG3Epinephrine8GG3-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.29Single8GG4Epinephrine8GG4-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.29Single8GG5Epinephrine8GG5-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.29Single8GGIEpinephrine8GGI-β2-Epinephrine
35.29Single8GGKEpinephrine8GGK-β2-Epinephrine
35.29Single8GGMEpinephrine8GGM-β2-Epinephrine
35.29Single8GGPEpinephrine8GGP-β2-Epinephrine
35.29Single8GGTEpinephrine8GGT-β2-Epinephrine
35.29Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2
35.29Single8GURPubChem 1048958GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2
35.29Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
35.29Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
35.29Single8JIMMMF8JIM-HCA2-MMF-Gi1/&β;1/&γ;2
35.29Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
35.29Single8JLNT1AM8JLN-TA1-T1AM-Gs/&β;1/&γ;2
35.29Single8K5CAcipimox8K5C-HCA2-Acipimox
35.29Single8UNQEpinephrine8UNQ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.29Single8UNREpinephrine8UNR-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.29Single8UNSEpinephrine8UNS-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.29Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/&β;1/&γ;2
35.29Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
35.29Consensus5ht2a_onOrthosteric Ligand7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.29Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
35.29Consensusd1_on_alloOrthosteric Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
35.29Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
35.29Consensusgs_tarOrthosteric Ligand8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
35.29Consensushca_onOrthosteric Ligandhca2_on hca3_on
35.29Consensushcar_onOrthosteric Ligandhca_on
35.29Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
35.29Consensusvasopressin-ot_offOrthosteric Ligandot_off
35.00Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
35.00Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
35.00Single5CXVTiotropium5CXV-M1-Tiotropium
35.00Single6A93Risperidone6A93-5-HT2A-Risperidone
35.00Single6HLPNetupitant6HLP-NK1-Netupitant
35.00Single6KQIPubMed 1048956KQI-CB1-PubMed 104895-ORG27569
35.00Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
35.00Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
35.00Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
35.00Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
35.00Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
35.00Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
35.00Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
35.00Single7XMTJ-21567XMT-SST4-J-2156-Gi1/&β;1/&γ;2
35.00Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
35.00Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.00Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2
35.00Single8IJDMK68928IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
35.00Single8JJLOlodaterol8JJL-β2-Olodaterol
35.00Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/&β;1/&γ;2
35.00Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
35.00Consensusbeta1_onOrthosteric Ligand7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
35.00Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
35.00Consensuscannabinoid_onOrthosteric Ligandcb1_on cb2_on
35.00Consensuscb1_off_alloOrthosteric Ligand6KQI-CB1-PubMed 104895-ORG27569
35.00Consensuscb1_onOrthosteric Ligand8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
35.00Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
35.00Consensusgi_cannabinoidOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
35.00Consensusgs_trhOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
35.00Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
35.00Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
35.00Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
34.78Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
33.33Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
33.33Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
33.33Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
33.33Single2Y01Dobutamine2Y01-β1-Dobutamine
33.33Single2Y02Carmoterol2Y02-β1-Carmoterol
33.33Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
33.33Single4U16N-Methyl Scopolamine4U16-M3-N-Methyl Scopolamine
33.33Single4X1HNonyl Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
33.33Single4YAYZD-71554YAY-AT1-ZD-7155
33.33Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
33.33Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
33.33Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
33.33Single5YC8N-Methyl Scopolamine5YC8-M2-N-Methyl Scopolamine
33.33Single5ZK8N-Methyl Scopolamine5ZK8-M2-N-Methyl Scopolamine
33.33Single5ZKCN-Methyl Scopolamine5ZKC-M2-N-Methyl Scopolamine
33.33Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
33.33Single6DRXLisuride6DRX-5-HT2B-Lisuride
33.33Single6GPSMK08126GPS-CCR2-MK0812
33.33Single6IIVDaltroban6IIV-TP-Daltroban
33.33Single6PS1Timolol6PS1-β2-Timolol
33.33Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
33.33Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
33.33Single7LJCPubChem 867641037LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
33.33Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
33.33Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
33.33Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
33.33Single7V3ZPubMed 1048957V3Z-CB1-PubMed 104895
33.33Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
33.33Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
33.33Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
33.33Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;2
33.33Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
33.33Single7XZ6APD6687XZ6-GPR119-APD668-Gs/&β;1/&γ;2
33.33Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
33.33Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
33.33Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
33.33Single8EFQDamgo8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
33.33Single8GEBEpinephrine8GEB-β2-Epinephrine-Gs/&β;1/&γ;2
33.33Single8GGBEpinephrine8GGB-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8GGREpinephrine8GGR-β2-Epinephrine
33.33Single8GGZEpinephrine8GGZ-β2-Epinephrine
33.33Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/&β;1/&γ;2
33.33Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/&β;1/&γ;2
33.33Single8J6QBeta-hydroxybutyrate8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
33.33Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
33.33Single8JLZST19368JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
33.33Single8K5DGSK2560738K5D-HCA2-GSK256073
33.33Single8POKHistamine8POK-H2-Histamine-Gs/&β;1/&γ;2
33.33Single8UNMEpinephrine8UNM-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
33.33Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Single8WRZ8D08WRZ-CB1-8D0-Arrestin1
33.33Single8X63Mepyramine8X63-H1-Mepyramine
33.33Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
33.33Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
33.33Consensusadenosine_onOrthosteric Liganda1_on a2_on
33.33Consensuscb1_on_alloOrthosteric Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
33.33Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
33.33Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Consensusgi_5htOrthosteric Ligand7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
33.33Consensusgo_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
33.33Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
33.33Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
33.33Consensushcar_offOrthosteric Ligandsuccinate_off
33.33Consensushistamine_onOrthosteric Ligandh1_on h4_on
33.33Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
33.33Consensusm2_on_alloOrthosteric Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
33.33Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
33.33Consensusnucleotide_onOrthosteric Ligandadenosine_on
33.33Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
33.33Consensustp_offOrthosteric Ligand6IIV-TP-Daltroban 6IIU-TP-Ramatroban
32.14Single6IGLIRL16206IGL-ETB-IRL1620
32.14Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
32.00Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
32.00Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
32.00Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
32.00Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
32.00Single8IHFMK68928IHF-HCA2-MK6892-Gi1/&β;1/&γ;2
32.00Single8J6IMK68928J6I-HCA2-MK6892-Gi1/&β;1/&γ;2
32.00Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
31.82Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
31.82Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
31.82Single8IYHMK68928IYH-HCA2-MK6892-Go/&β;1/&γ;2
31.82Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
31.58Single2Y00Dobutamine2Y00-β1-Dobutamine
31.58Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
31.58Single6GPXMK08126GPX-CCR2-MK0812
31.58Single7CFNINT-7777CFN-GPBA-INT-777-Gs/&β;1/&γ;2
31.58Single7CKXA776367CKX-D1-A77636-Gs/&β;1/&γ;2
31.58Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
31.58Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
31.58Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
31.58Single7SINNPS-21437SIN-CaS-NPS-2143
31.58Single7SINNPS-21437SIN-CaS-NPS-2143
31.58Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
31.58Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
31.58Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
31.58Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
31.58Single7YXAONO-54306087YXA-S1P5-ONO-5430608
31.58Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
31.58Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
31.58Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
31.58Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
31.58Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide 6DRX-5-HT2B-Lisuride
31.58Consensusa1_on_alloOrthosteric Ligand7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
31.58Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
31.58Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
31.58Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
31.58Consensusgs_muscarinicOrthosteric Ligand8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
31.58Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
31.58Consensusm2_offOrthosteric Ligand5ZKB-M2-AF-DX 384 5ZKC-M2-N-Methyl Scopolamine 5ZK3-M2-Quinuclidinyl benzilate hydrobromide
31.58Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
31.25Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
31.25Single3PBLEticlopride3PBL-D3-Eticlopride
31.25Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
31.25Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
31.25Single6TP4ACT-4622066TP4-OX1-ACT-462206
31.25Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
31.25Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
31.25Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
31.25Single7SRQLSD7SRQ-5-HT2B-LSD
31.25Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2
31.25Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2
31.25Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.25Single8EF6Morphine8EF6-μ-Morphine-Gi1/&β;1/&γ;2
31.25Single8GGSEpinephrine8GGS-β2-Epinephrine
31.25Single8GGYEpinephrine8GGY-β2-Epinephrine
31.25Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2
31.25Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2
31.25Single8IJANiacin8IJA-HCA2-Niacin-Gi1/&β;1/&γ;2
31.25Single8ITFDMCHA8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
31.25Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
31.25Single8K5BNiacin8K5B-HCA2-Niacin
31.25Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
31.25Single8UNVEpinephrine8UNV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
31.25Single8UNXEpinephrine8UNX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
31.25Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
31.25Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
31.25Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
31.03Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
30.77Single7KH0Acyclovir triphosphate7KH0-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
30.77Consensusbombesin_onOrthosteric Ligandbb2_on bb1_on
30.43Single4IARErgotamine4IAR-5-HT1B-Ergotamine
30.43Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
30.43Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
30.43Single7QA8Peptide7QA8-STE2-Peptide
30.43Single7QA8Peptide7QA8-STE2-Peptide
30.43Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
30.43Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
30.43Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
30.43Single8GHVPubChem 1459649038GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
30.43Single8J6RMK68928J6R-HCA2-MK6892-Gi1/&β;1/&γ;2
30.43Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
30.43Consensusclass-d_offOrthosteric Ligandste2_off
30.43Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
30.43Consensussst_onOrthosteric Ligandsst2_on sst4_on
30.43Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
30.00Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
30.00Single5V54Methiothepin5V54-5-HT1B-Methiothepin
30.00Single5XR8AM8415XR8-CB1-AM841
30.00Single5XRAAM115425XRA-CB1-AM11542
30.00Single6E59L-7607356E59-NK1-L-760735
30.00Single6J20Aprepitant6J20-NK1-Aprepitant
30.00Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
30.00Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
30.00Single7B6WCyclazosin7B6W-α1b-Cyclazosin
30.00Single7EPENAM5637EPE-mGlu-NAM563
30.00Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
30.00Single7JV5SKF812977JV5-D1-SKF81297-Gs/&β;1/&γ;2
30.00Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
30.00Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
30.00Single7XTQR3997XTQ-GPBA-R399-Gs/&β;1/&γ;2
30.00Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
30.00Single8G056-OAU8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
30.00Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2
30.00Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
30.00Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.00Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2
30.00Single8JXWVUF68848JXW-H4-VUF6884-Gi1/&β;1/&γ;2
30.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
30.00Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
30.00Consensus5ht1_offOrthosteric Ligand5ht1b_off
30.00Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
30.00Consensus5ht5_offOrthosteric Ligand5ht5a_off
30.00Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
30.00Consensusalpha1b_offOrthosteric Ligand7B6W-α1b-Cyclazosin
30.00Consensusffa4_onOrthosteric Ligand8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
30.00Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A-NECA-Gs/&β;1/&γ;1 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
30.00Consensusgs_compl-peptideOrthosteric Ligand8I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.00Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
30.00Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
30.00Consensuslpa_onOrthosteric Ligandlpa1_on
30.00Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl Scopolamine 5ZHP-M3-PubChem 134828589
30.00Consensusnk1_offOrthosteric Ligand6J20-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
30.00Consensussst4_onOrthosteric Ligand7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
29.63Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
29.63Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
29.63Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.63Consensusbb1_onOrthosteric Ligand8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.63Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
29.41Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
29.41Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
29.41Single3ODUIT1t3ODU-CXCR4-IT1t
29.41Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
29.41Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;1
29.41Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
29.41Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
29.41Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
29.41Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
29.41Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
29.41Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
29.41Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
29.41Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
29.41Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2
29.41Single8A6CAll-trans-retinal8A6C-Rhodopsin-All-trans-retinal
29.41Single8A6DAll-trans-retinal8A6D-Rhodopsin-All-trans-retinal
29.41Single8A6EAll-trans-retinal8A6E-Rhodopsin-All-trans-retinal
29.41Single8GEAEpinephrine8GEA-β2-Epinephrine-Gs/&β;1/&γ;2
29.41Single8GEDEpinephrine8GED-β2-Epinephrine-Gs/&β;1/&γ;2
29.41Single8GG7Epinephrine8GG7-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
29.41Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2
29.41Single8IW4Spermidine8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
29.41Single8IWESpermidine8IWE-TAAR9-Spermidine
29.41Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/&β;1/&γ;2
29.41Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
29.41Single8UNLEpinephrine8UNL-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
29.41Single8UNOEpinephrine8UNO-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
29.41Single8UNTEpinephrine8UNT-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
29.41Single8UNUEpinephrine8UNU-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
29.41Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
29.41Consensus5ht2_onOrthosteric Ligand5ht2a_on 5ht2c_on
29.41Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
29.41Consensusgs_5htOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
29.41Consensusmglu_onOther Ligandmglu2_on mglu4_on
29.41Consensusopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
29.17Single3QAKUK-4320973QAK-A2A-UK-432097
29.17Single6HLOAprepitant6HLO-NK1-Aprepitant
29.17Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
29.17Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
29.17Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
29.03Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
28.57Single3PXOAll-trans-retinal3PXO-Rhodopsin-All-trans-retinal
28.57Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
28.57Single5DYSAll-trans-retinal5DYS-Rhodopsin-All-trans-retinal
28.57Single5X33BIIL2605X33-BLT1-BIIL260
28.57Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
28.57Single6CM4Risperidone6CM4-D2-Risperidone
28.57Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
28.57Single6IIURamatroban6IIU-TP-Ramatroban
28.57Single6MXTSalmeterol6MXT-β2-Salmeterol
28.57Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
28.57Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/&β;1/&γ;2
28.57Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
28.57Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
28.57Single7K15MKD0467K15-BLT1-MKD046-Na
28.57Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
28.57Single7WCNAR2314537WCN-GPR119-AR231453-Gs/&β;1/&γ;2
28.57Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
28.57Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
28.57Single8GCPPGE28GCP-EP4-PGE2-Gi1/&β;1/&γ;2
28.57Single8GEJEpinephrine8GEJ-β2-Epinephrine-Gs/&β;1/&γ;2
28.57Single8I95EP548I95-C3aB-EP54-Go/&β;1/&γ;2
28.57Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2
28.57Single8JWZAB9288JWZ-A2A-AB928-Na
28.57Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
28.57Single8WU1KCA8WU1-CB1-KCA-Arrestin1
28.57Consensusblt1_offOrthosteric Ligand7K15-BLT1-MKD046-Na
28.57Consensusblt_offOrthosteric Ligandblt1_off
28.57Consensusgabab_offOther Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
28.57Consensusgi_class-fOther Ligandgi_frizzled
28.57Consensusgi_frizzledOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
28.57Consensusgi_prostanoidOrthosteric Ligand8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GDC-EP3-PGE2-Gi1/&β;1/&γ;2 8GCM-EP4-L902688-Gi1/&β;1/&γ;2
28.57Consensusgs_bileacidOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
28.57Consensusgs_steroidOrthosteric Ligandgs_bileacid
28.00Single5WF5UK-4320975WF5-A2A-UK-432097
28.00Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1
27.78Single3RZECidoxepin3RZE-H1-Cidoxepin
27.78Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
27.78Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
27.78Single6A94Zotepine6A94-5-HT2A-Zotepine
27.78Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
27.78Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
27.78Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
27.78Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
27.78Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/&β;1/&γ;2
27.78Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
27.78Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
27.78Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
27.78Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
27.78Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
27.78Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
27.78Single8GDZEpinephrine8GDZ-β2-Epinephrine-Gs/&β;1/&γ;2
27.78Single8GG8Epinephrine8GG8-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
27.78Single8GGLEpinephrine8GGL-β2-Epinephrine
27.78Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.78Single8JERAcipimox8JER-HCA2-Acipimox-Go/&β;1/&γ;2
27.78Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
27.78Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2
27.78Single8UHBRO52563908UHB-TA1-RO5256390-Gs/&β;1/&γ;2
27.78Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6WH4-5-HT2A-Methiothepin 7VOE-5-HT2A-Aripiprazole 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 6A93-5-HT2A-Risperidone
27.78Consensush3_on_alloOrthosteric Ligand7F61-H3-PF-03654746-Cholesterol
27.78Consensusm1_off_alloOrthosteric Ligand6WJC-M1-Atropine-Muscarinic toxin 7
27.78Consensussensory_offOrthosteric Ligandopsin_off
27.59Single7VGXNeuropeptide Y7VGX-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
27.59Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
27.27Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
27.27Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
27.27Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
27.27Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
27.27Single7EZCUKA7EZC-A2A-UKA
27.27Single7UM4AS26747237UM4-5-HT5A-AS2674723
27.27Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
27.27Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
27.27Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
27.27Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
27.27Consensus5ht5a_offOrthosteric Ligand7UM4-5-HT5A-AS2674723
27.27Consensusbileacid_onOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
27.27Consensusep4_onOrthosteric Ligand7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2
27.27Consensusffa4_on_alloOrthosteric Ligand8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
27.27Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
27.27Consensusgs_prostanoidOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.27Consensusot_onOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
27.27Consensussteroid_onOrthosteric Ligandbileacid_on
26.92Consensusgi_somatostatinOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
26.67Single2HPYAll-trans-retinal2HPY-Rhodopsin-All-trans-retinal
26.67Single5GLHEndothelin-15GLH-ETB-Endothelin-1
26.67Single6IGKEndothelin-36IGK-ETB-Endothelin-3
26.67Single6OY9All-trans-retinal6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
26.67Single6TQ9SB-4081246TQ9-OX1-SB-408124
26.67Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
26.67Single8IWM2-Phenylethylamine8IWM-TAAR9-2-Phenylethylamine
26.67Consensushca2_on_alloOrthosteric Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
26.67Consensussensory_onOrthosteric Ligandopsin_on
26.32Single4DAJTiotropium4DAJ-M3-Tiotropium
26.32Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
26.32Single4MQSIperoxo4MQS-M2-Iperoxo
26.32Single4U14Tiotropium4U14-M3-Tiotropium
26.32Single5DSGTiotropium5DSG-M4-Tiotropium
26.32Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
26.32Single5TGZAM65385TGZ-CB1-AM6538
26.32Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
26.32Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
26.32Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2
26.32Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
26.32Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.32Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
26.32Single7F83PF-051904577F83-Ghrelin-PF-05190457
26.32Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
26.32Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
26.32Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
26.32Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
26.32Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
26.32Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
26.32Single8J18(3R)-3-hydroxydodecanoic acid8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
26.32Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
26.32Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
26.32Consensus5ht1a_onOrthosteric Ligand8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
26.32Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
26.32Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
26.32Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
26.32Consensusm4_on_alloOrthosteric Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
26.32Consensusprostanoid_offOrthosteric Ligandep_off tp_off dp_off
26.32Consensustachykinin_offOrthosteric Ligandnk1_off
26.09Single5WF6UK-4320975WF6-A2A-UK-432097
26.09Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
26.09Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
26.09Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
26.09Single7XN9L-054,5227XN9-SST2-L-054,522
26.09Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
26.09Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2 8I95-C3aB-EP54-Go/&β;1/&γ;2
26.09Consensusclass-d_offOrthosteric Ligandste2_off
26.09Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
26.09Consensusfpr2-alx_onOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
26.09Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
26.09Consensusgo_vasopressinOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
25.93Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
25.93Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
25.93Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.93Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
25.93Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.93Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
25.81Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
25.00Single3OE6IT1t3OE6-CXCR4-IT1t
25.00Single3OE8IT1t3OE8-CXCR4-IT1t
25.00Single3PQRAll-trans-retinal3PQR-Rhodopsin-All-trans-retinal-Gt(CT)
25.00Single4WW3All-trans-retinal4WW3-Rhodopsin-All-trans-retinal
25.00Single4XT1Fractalkine4XT1-US28-Fractalkine
25.00Single5CGCHTL142425CGC-mGlu5-HTL14242
25.00Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
25.00Single5ZK3Quinuclidinyl benzilate hydrobromide5ZK3-M2-Quinuclidinyl benzilate hydrobromide
25.00Single6FUFAll-trans-retinal6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2
25.00Single6GDGNECA6GDG-A2A-NECA-Gs/&β;1/&γ;1
25.00Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
25.00Single6LUQHaloperidol6LUQ-D2-Haloperidol
25.00Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
25.00Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
25.00Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
25.00Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
25.00Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
25.00Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/&β;1/&γ;2
25.00Single7MT8All-trans-retinal7MT8-Rhodopsin-All-trans-retinal-GRK1
25.00Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
25.00Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2
25.00Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
25.00Single7WC5Psilocin7WC5-5-HT2A-Psilocin
25.00Single8EA0Iperoxo8EA0-M3-Iperoxo
25.00Single8G59TUG-8918G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
25.00Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2
25.00Single8GDAL9026888GDA-EP4-L902688-Gs/&β;1/&γ;2
25.00Single8GDCPGE28GDC-EP3-PGE2-Gi1/&β;1/&γ;2
25.00Single8IW72-Phenylethylamine8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
25.00Single8J19PubChem 1270454228J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
25.00Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/&β;1/&γ;2
25.00Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
25.00Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
25.00Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Consensusa2a_onOrthosteric Ligand6GDG-A2A-NECA-Gs/&β;1/&γ;1
25.00Consensusccr2_off_alloOther Ligand5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
25.00Consensusep3_onOrthosteric Ligand8GDC-EP3-PGE2-Gi1/&β;1/&γ;2
25.00Consensusfpr-alx_onOrthosteric Ligandfpr1-alx_on fpr2-alx_on
25.00Consensusgi_neuromedinOrthosteric Ligand7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
25.00Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
25.00Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
25.00Consensusopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
25.00Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
25.00Consensussst2_onOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
24.24Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
24.24Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
24.14Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
24.14Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
24.14Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
24.14Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
24.14Consensusendothelin_onOrthosteric Ligandetb_on eta_on
24.14Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
24.00Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
24.00Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
24.00Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
24.00Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/&β;1/&γ;2
24.00Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
24.00Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
24.00Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
24.00Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
24.00Consensusalpha1_offOrthosteric Ligandalpha1a_off alpha1b_off
24.00Consensuscx3cr_onOrthosteric Ligandcx3cr1_on
24.00Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
24.00Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
23.81Single3UONQuinuclidinyl benzilate hydrobromide3UON-M2-Quinuclidinyl benzilate hydrobromide
23.81Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
23.81Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
23.81Single7P2L4YI7P2L-mGlu5-4YI
23.81Single7TUYGSK682753A7TUY-GPR183-GSK682753A
23.81Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2
23.81Single7W41PD1762527W41-BB2-PD176252
23.81Single8GDBPGE28GDB-EP4-PGE2-Gs/&β;1/&γ;2
23.81Single8GUSHU-3088GUS-CB2-HU-308-Gi1/&β;1/&γ;2
23.81Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
23.81Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
23.81Single8JD0J9R8JD0-mGlu2; mGlu3-Glutamate-J9R
23.81Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
23.81Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
23.81Consensus5ht1b_onOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
23.81Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
23.81Consensusbombesin_offOrthosteric Ligandbb2_off
23.81Consensuscck_onOrthosteric Ligandccka_on cckb_on
23.81Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
23.81Consensusgi_ffaOrthosteric Ligand8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
23.81Consensusgi_muscarinicOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
23.81Consensusgs_ffaOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2 8GDB-EP4-PGE2-Gs/&β;1/&γ;2
23.81Consensusnpy_offOrthosteric Ligandnpy2_off npy1_off
23.81Consensusrelaxin_onOrthosteric Ligandrxfp4_on
23.81Consensuss1p2_onOrthosteric Ligand7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
23.53Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
23.53Single2G87All-trans-retinal2G87-Rhodopsin-All-trans-retinal
23.53Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
23.53Single3OE9IT1t3OE9-CXCR4-IT1t
23.53Single6HLLCP999946HLL-NK1-CP99994
23.53Single6QNOAll-trans-retinal6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
23.53Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
23.53Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
23.53Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
23.53Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
23.53Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/&β;1/&γ;2
23.53Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
23.53Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.53Single8IY9Niacin8IY9-HCA2-Niacin-Go/&β;1/&γ;2
23.53Single8JILNiacin8JIL-HCA2-Niacin-Gi1/&β;1/&γ;2
23.53Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
23.53Single8X2K5YM8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
23.53Consensus5ht4_onOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
23.53Consensusclass-t_onOrthosteric Ligandtaste2_on
23.53Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
23.53Consensusgs_class-tOrthosteric Ligandgs_taste
23.53Consensusgs_tasteOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
23.53Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
23.53Consensustaste2_onOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
23.33Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
23.33Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
23.33Consensusgs_endothelinOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.33Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
23.08Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
23.08Single6W25SHU91196W25-MC4-SHU9119-Ca
23.08Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
23.08Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
23.08Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
23.08Consensusangiotensin_onOrthosteric Ligandat1_on
23.08Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
23.08Consensuscx3cr1_onOrthosteric Ligand7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
23.08Consensusgi_chemerinOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
23.08Consensusgi_formylpeptideOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
23.08Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
22.73Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
22.73Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
22.73Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
22.73Single8JWYPubChem 1684517108JWY-A2A-PubChem 168451710
22.73Consensusep_onOrthosteric Ligandep4_on ep2_on ep3_on
22.73Consensusgpr119_onOrthosteric Ligand7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
22.73Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
22.73Consensusprostanoid_onOrthosteric Ligandep_on fpa_on
22.22Single2X72All-trans-retinal2X72-Rhodopsin-All-trans-retinal-Gt(CT)
22.22Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/&β;1/&γ;2
22.22Single6JODAngiotensin II6JOD-AT2-Angiotensin II
22.22Single6NWEOctyl Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
22.22Single6OYAAll-trans-retinal6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
22.22Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
22.22Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
22.22Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
22.22Single7F8YDevazepide7F8Y-CCKA-Devazepide
22.22Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.22Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
22.22Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
22.22Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
22.22Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
22.22Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/&β;1/&γ;2
22.22Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
22.22Single8UO1Epinephrine8UO1-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
22.22Consensus5ht2c_onOrthosteric Ligand8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.22Consensusclass-d_onOrthosteric Ligandste2_on
22.22Consensusgi_class-dOrthosteric Ligandgi_ste
22.22Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
22.22Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
22.22Consensusgt_class-aOrthosteric Ligandgt_opsin
22.22Consensusgt_opsinOrthosteric Ligandgt_sensory
22.22Consensusgt_sensoryOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
22.22Consensusmelatonin_onOrthosteric Ligandmt1_on mt2_on
22.22Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
21.88Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
21.88Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
21.74Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
21.74Single5CGDHTL142425CGD-mGlu5-HTL14242
21.74Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
21.74Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
21.74Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
21.74Single8ID8TUG-8918ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
21.74Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.74Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
21.74Consensuscckb_onOrthosteric Ligand7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
21.74Consensusgs_lipidOrthosteric Ligandgs_ffa gs_prostanoid
21.43Single4A4MAll-trans-retinal4A4M-Rhodopsin-All-trans-retinal-Gt(CT)
21.43Single5EN0All-trans-retinal5EN0-Rhodopsin-All-trans-retinal-Gt(CT)
21.43Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
21.43Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
21.43Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
21.43Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
21.43Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
21.43Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
21.43Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
21.43Consensusbk1_onOrthosteric Ligand7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.43Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
21.43Consensusgs_bradykininOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.05Single5TE3Octyl Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
21.05Single7BB6Acyclovir triphosphate7BB6-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
21.05Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.05Single7VODCariprazine7VOD-5-HT2A-Cariprazine
21.05Single7XOVSR1461317XOV-CCKA-SR146131-Gs/&β;1/&γ;2
21.05Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
21.05Single8JHNMMF8JHN-HCA2-MMF-Go/&β;1/&γ;2
21.05Single8K2WAMG4878K2W-CXCR3-AMG487
21.05Consensusgi_melatoninOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
20.83Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
20.83Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.83Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.83Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
20.83Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.83Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
20.83Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
20.83Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
20.69Single4XT3Fractalkine4XT3-US28-Fractalkine
20.69Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
20.69Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.69Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
20.69Consensusclass-d_onOrthosteric Ligandste2_on
20.69Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
20.69Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
20.59Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
20.59Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
20.59Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
20.51Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
20.00Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
20.00Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
20.00Single7CFMP3957CFM-GPBA-P395-Gs/&β;1/&γ;2
20.00Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
20.00Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
20.00Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
20.00Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/&β;1/&γ;2
20.00Single7WC4Serotonin7WC4-5-HT2A-Serotonin
20.00Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
20.00Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
20.00Single8CU6LJ-45178CU6-A2A-LJ-4517
20.00Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
20.00Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
20.00Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
20.00Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
20.00Consensuscck_offOrthosteric Ligandccka_off
20.00Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
20.00Consensusetb_onOrthosteric Ligand8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
20.00Consensusgi_class-dOrthosteric Ligandgi_ste
20.00Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
20.00Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
20.00Consensusgo_class-b1Orthosteric Ligandgo_crf
20.00Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
20.00Consensusnmur1_onOrthosteric Ligand7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
20.00Consensuspth_onOrthosteric Ligandpth1_on pth2_on
19.35Single8IY6Endothelin-18IY6-ETB-Endothelin-1
19.23Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
19.23Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
19.23Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
19.23Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.05Single5N2RPubChem 92460631; psb365N2R-A2A-PubChem 92460631; psb36-Na
19.05Single5N2SPSB365N2S-A1-PSB36
19.05Single5NM2ZM2413855NM2-A2A-ZM241385-Na
19.05Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
19.05Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
19.05Single6D26Fevipiprant6D26-DP2-Fevipiprant
19.05Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
19.05Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
19.05Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
19.05Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
19.05Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
19.05Single8ID9Eicosapentaenoic acid8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
19.05Single8QOTNanobody E8QOT-μ-Nanobody E
19.05Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
19.05Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
19.05Consensusep_offOrthosteric Ligandep4_off
18.92Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
18.92Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
18.75Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
18.75Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
18.75Single7MTBAll-trans-retinal7MTB-Rhodopsin-All-trans-retinal-GRK1
18.75Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
18.75Consensusgs_crfOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
18.52Single7F4DAlpha-MSH7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
18.52Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
18.52Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
18.52Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
18.52Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.52Consensusmc5_onOrthosteric Ligand8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
18.52Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
18.18Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
18.18Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
18.18Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
18.18Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
18.18Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
18.18Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
18.18Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
18.18Single7XOWGastrin7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
18.18Single7XOXCholecystokinin-87XOX-CCKB-Cholecystokinin-8-Gq/&β;1/&γ;2
18.18Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
18.18Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
18.18Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.18Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
18.18Single8X79MRE-2698X79-I2-MRE-269-Gs/&β;1/&γ;2
18.18Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
18.18Consensusadenosine_offOrthosteric Liganda1_off a2_off
18.18Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
18.18Consensuscyslt1_off_ortoalloOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
17.86Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
17.86Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
17.86Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
17.86Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
17.86Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
17.86Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
17.86Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
17.86Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
17.86Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
17.86Consensusnmur2_onOrthosteric Ligand7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.86Consensusnmur_onOrthosteric Ligandnmur1_on nmur2_on
17.65Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
17.65Single3UZAGTPL92363UZA-A2A-GTPL9236
17.65Single5WKTOctyl Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
17.65Single7MT9All-trans-retinal7MT9-Rhodopsin-All-trans-retinal-GRK1
17.65Single7MTAAll-trans-retinal7MTA-Rhodopsin-All-trans-retinal-GRK1
17.65Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.65Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
17.65Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
17.65Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
17.65Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
17.39Single4N4WSANT-14N4W-SMO-SANT-1
17.39Single4PY02MeSATP4PY0-P2Y12-2MeSATP
17.39Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1
17.39Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
17.39Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.39Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
17.39Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/&β;1/&γ;2
17.39Single7Y24Octreotide7Y24-SST2-Octreotide-Go/&β;1/&γ;2
17.39Single7Y66BM2137Y66-C5a1-BM213-Gi1/&β;1/&γ;2
17.39Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.39Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.39Single8J6DEP1418J6D-C3aB-EP141-Go/&β;1/&γ;2
17.39Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg3_on
17.39Consensuschemokine_offOrthosteric Ligandcxcr_off
17.39Consensusclass-b2_onOrthosteric Ligandadgrg_on
17.39Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
17.39Consensuscxcr_offOrthosteric Ligandcxcr4_off
17.39Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
17.39Consensusdp_offOrthosteric Liganddp2_off
17.24Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
17.24Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.24Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
17.24Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
17.24Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
17.24Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.24Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
17.24Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.24Consensusgs_melanocortinOrthosteric Ligand7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2
17.24Consensusgs_neuromedinOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.14Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
17.14Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
16.67Single3AYMAll-trans-retinal3AYM-Rhodopsin-All-trans-retinal
16.67Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
16.67Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
16.67Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
16.67Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
16.67Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/&β;1/&γ;2
16.67Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
16.67Single7CX2PGE27CX2-EP2-PGE2-Gs/&β;1/&γ;2
16.67Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2
16.67Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2
16.67Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
16.67Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
16.67Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
16.67Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
16.67Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
16.67Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
16.67Consensusep2_onOrthosteric Ligand7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
16.67Consensusfpa_onOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Consensusmt1_onOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
16.67Consensusmt2_onOrthosteric Ligand7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
16.67Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.13Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
16.13Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
16.00Single5EE7MK08935EE7-Glucagon-MK0893
16.00Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
16.00Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
16.00Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
16.00Single8INRAlpha-MSH8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
16.00Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.00Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.00Single8XZFWN5618XZF-Apelin-WN561-Gi1/&β;1/&γ;2
16.00Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
16.00Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
16.00Consensusgs_adgrOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
16.00Consensusgs_bombesinOrthosteric Ligand8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.00Consensusgs_class-b2Orthosteric Ligandgs_adgr
16.00Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.00Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.79Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
15.79Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
15.79Single3VGAZM2413853VGA-A2A-ZM241385-Antibody
15.79Single5ZKQABT-4915ZKQ-PAF-ABT-491
15.79Single6ME2Ramelteon6ME2-MT1-Ramelteon
15.79Single7BR3Elagolix7BR3-GnRH1-Elagolix
15.79Single7F8ULintitript7F8U-CCKA-Lintitript
15.79Single7TUZ7alpha,25-dihydroxycholesterol7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
15.79Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
15.79Single7W0OElabela7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
15.79Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
15.79Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
15.79Single8GNGIstradefylline8GNG-A2A-Istradefylline
15.79Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
15.79Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
15.79Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.79Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
15.79Consensusa2a_off_alloOrthosteric Ligand6ZDR-A2A-HMS1413f12-Na 6GT3-A2A-Imaradenant-Na 8CU7-A2A-LJ-4517-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PubChem 92460631; psb36-Na 5MZJ-A2A-Theophylline-Na 5OLO-A2A-Tozadenant-Na 5OLH-A2A-Vipadenant-Na 5NM4-A2A-ZM241385-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5MZP-A2A-Caffeine-Na 8CIC-A2A-Etrumadenant-Na
15.79Consensusffa3_on_alloOrthosteric Ligand8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
15.79Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
15.62Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
15.62Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
15.62Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
15.62Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
15.62Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
15.62Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
15.62Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
15.62Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
15.62Consensuscrf1_onOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
15.62Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
15.62Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
15.38Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
15.38Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
15.38Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
15.38Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
15.38Single7F8XNN90567F8X-CCKA-NN9056
15.38Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.38Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
15.38Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
15.15Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
15.15Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
15.00Single5IU7Q274563465IU7-A2A-Q27456346-Na
15.00Single5JTBZM2413855JTB-A2A-ZM241385
15.00Single5K2BZM2413855K2B-A2A-ZM241385-Na
15.00Single6AQFZM2413856AQF-A2A-ZM241385
15.00Single6FFIMMPEP6FFI-mGlu5-MMPEP
15.00Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
15.00Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
15.00Single6MH8ZM2413856MH8-A2A-ZM241385
15.00Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
15.00Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
15.00Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
15.00Single6ZDVPubChem 9840736ZDV-A2A-PubChem 984073-Na
15.00Single7AROLUF58337ARO-A2A-LUF5833-Na
15.00Single7T32ZM2413857T32-A2A-ZM241385
15.00Single7VVOPTH7VVO-PTH1-PTH-Gs/&β;1/&γ;2
15.00Single8GCML9026888GCM-EP4-L902688-Gi1/&β;1/&γ;2
15.00Single8K4NVF08K4N-GPR34-VF0-Gi1/&β;1/&γ;2
15.00Single8T3VDHA8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.00Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
15.00Consensusffa2_onOrthosteric Ligand8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
15.00Consensusgnrh_offOrthosteric Ligandgnrh1_off
14.81Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
14.81Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
14.81Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
14.81Single7SK5CXCL127SK5-ACKR3-CXCL12
14.81Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
14.71Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
14.71Consensusglp_onOrthosteric Ligandglp1_on glp2_on
14.29Single3EMLZM2413853EML-A2A-ZM241385
14.29Single3OE0CVX153OE0-CXCR4-CVX15
14.29Single4EIYZM2413854EIY-A2A-ZM241385-Na
14.29Single5IU8Q274563475IU8-A2A-Q27456347-Na
14.29Single5K2AZM2413855K2A-A2A-ZM241385-Na
14.29Single5OLGZM2413855OLG-A2A-ZM241385-Na
14.29Single5UENDU1725UEN-A1-DU172
14.29Single5UIGJ3.651.884G5UIG-A2A-J3.651.884G
14.29Single5VRAZM2413855VRA-A2A-ZM241385-Na
14.29Single6FFHFenobam6FFH-mGlu5-Fenobam
14.29Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
14.29Single6S0LZM2413856S0L-A2A-ZM241385
14.29Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
14.29Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
14.29Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
14.29Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
14.29Single7PYRPSB-21157PYR-A2A-PSB-2115
14.29Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
14.29Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
14.29Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
14.29Single8EJKTAK-8758EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
14.29Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
14.29Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
14.29Consensusa2_offOrthosteric Liganda2a_off
14.29Consensusa2a_offOrthosteric Ligand8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 5UIG-A2A-J3.651.884G 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-PubChem 168451710 5K2D-A2A-ZM241385
14.29Consensusffa_onOrthosteric Ligandffa4_on ffa1_on ffa2_on ffa3_on
14.29Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
14.29Consensusp2y12_offOrthosteric Ligand4NTJ-P2Y12-AZD1283 7PP1-P2Y12-Selatogrel
14.29Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
14.29Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
13.89Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
13.89Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
13.79Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
13.79Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
13.79Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
13.79Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
13.79Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
13.79Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
13.64Single4NTJAZD12834NTJ-P2Y12-AZD1283
13.64Single5IUAQ274563485IUA-A2A-Q27456348-Na
13.64Single6LPLZM2413856LPL-A2A-ZM241385-Na
13.64Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
13.64Single6S0QZM2413856S0Q-A2A-ZM241385
13.64Single6WQAZM2413856WQA-A2A-ZM241385-Na
13.64Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
13.64Single7RM5ZM2413857RM5-A2A-ZM241385-Na
13.64Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
13.64Single8FYNZM2413858FYN-A2A-ZM241385-Na
13.64Single8GNEKW-63568GNE-A2A-KW-6356-Na
13.64Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
13.51Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
13.33Single5MZPCaffeine5MZP-A2A-Caffeine-Na
13.33Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
13.33Single6W25Ca6W25-MC4-SHU9119-Ca
13.33Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
13.33Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
13.33Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
13.33Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
13.33Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
13.33Single8WCCCyclohexylammonium ion8WCC-TA1-Cyclohexylammonium ion
13.33Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
13.04Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
13.04Single7PX4PSB-21137PX4-A2A-PSB-2113
13.04Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.04Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2
13.04Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
13.04Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
13.04Consensuschemerin_onOrthosteric Ligandcml1_on
13.04Consensuscml1_onOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
13.04Consensusmglu2_onOther Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
13.04Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
12.90Single6FJ3PTH6FJ3-PTH1-PTH
12.90Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
12.90Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
12.90Single7D3SSecretin7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
12.90Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
12.90Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
12.90Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
12.90Single7SK3CXCL127SK3-ACKR3-CXCL12
12.90Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
12.90Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
12.90Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
12.90Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
12.50Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
12.50Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
12.50Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
12.50Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
12.50Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
12.50Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
12.50Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
12.50Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
12.50Single7XKEBetahydroxyandrosterone7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
12.50Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2
12.50Single8PWNTheophylline8PWN-A2A-Theophylline
12.50Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
12.50Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
12.50Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
12.50Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
12.50Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
12.50Consensusclass-c_onOther Ligandgabab_on mglu_on
12.50Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
12.50Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
12.12Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
12.12Single6LMLGlucagon6LML-Glucagon-Glucagon
12.12Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
12.12Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
12.12Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
12.12Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
12.00Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
12.00Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
12.00Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
12.00Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
12.00Consensusadgrg2_onOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
12.00Consensusc5a1_off_ortoalloOrthosteric Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
12.00Consensuscyslt2_offOrthosteric Ligand6RZ6-CysLT2-ONO-2570366 6RZ9-CysLT2-ONO-2770372 6RZ8-CysLT2-ONO-2080365
12.00Consensuscyslt_offOrthosteric Ligandcyslt2_off
11.90Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
11.76Single3RFMCaffeine3RFM-A2A-Caffeine
11.76Single8A2OTheophylline8A2O-A2A-Theophylline-Na
11.54Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
11.54Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
11.54Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
11.54Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
11.54Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.54Single8SAI1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
11.54Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
11.54Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
11.43Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
11.43Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
11.11Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
11.11Single6LI0GTPL98046LI0-GPR52-GTPL9804
11.11Single6ME5Agomelatine6ME5-MT1-Agomelatine
11.11Single6ME9Ramelteon6ME9-MT2-Ramelteon
11.11Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
11.11Single8EITDoconexent8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
11.11Single8F76-8F76-OR51E2-Gs/&β;1/&γ;2
11.11Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/&β;1/&γ;2
11.11Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
10.81Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
10.71Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.71Consensussst_offOrthosteric Ligandsst2_off
10.53Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
10.53Single5L7IVismodegib5L7I-SMO-Vismodegib
10.53Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
10.53Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
10.53Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
10.53Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
10.53Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
10.53Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
10.53Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
10.53Consensusgo_adhesionOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
10.53Consensusgo_class-b2Orthosteric Ligandgo_adhesion
10.53Consensusm4_on_alloOther Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
10.34Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.34Single7XNACYN1548067XNA-SST2-CYN154806
10.34Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
10.34Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
10.34Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
10.00Single3PWHZM2413853PWH-A2A-ZM241385
10.00Single3VG9ZM2413853VG9-A2A-ZM241385-Antibody
10.00Single4XNVBPTU4XNV-P2Y1-BPTU
10.00Single5K2DZM2413855K2D-A2A-ZM241385
10.00Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
10.00Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
10.00Single5U09Taranabant5U09-CB1-Taranabant
10.00Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
10.00Single6JZHZM2413856JZH-A2A-ZM241385-Na
10.00Single6PS7ZM2413856PS7-A2A-ZM241385-Na
10.00Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
10.00Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
10.00Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
10.00Single7WV9ZCZ0117WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
10.00Single8DWHCompound-168DWH-MRGPRX1-Compound-16-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.00Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
10.00Consensuscb1_on_alloOther Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
10.00Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
10.00Consensusm2_on_alloOther Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
10.00Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
9.68Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
9.52Single3REYPubChem 56973REY-A2A-PubChem 5697
9.52Single5IU4ZM2413855IU4-A2A-ZM241385-Na
9.52Single5IUBQ274563445IUB-A2A-Q27456344-Na
9.52Single5K2CZM2413855K2C-A2A-ZM241385-Na
9.52Single5NLXZM2413855NLX-A2A-ZM241385-Na
9.52Single5NM4ZM2413855NM4-A2A-ZM241385-Na
9.52Single5UVIZM2413855UVI-A2A-ZM241385
9.52Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
9.52Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
9.52Single6ZINSR486926ZIN-NTS1-SR48692
9.52Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
9.52Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
9.52Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
9.52Single7XJJGalanin7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
9.52Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
9.52Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.52Single8HQN9(S)-HODE8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
9.52Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
9.52Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
9.52Consensusgo_galaninOrthosteric Ligand7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
9.52Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
9.52Consensusm1_off_alloOther Ligand6WJC-M1-Atropine-Muscarinic toxin 7
9.09Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
9.09Single6D27CAY104716D27-DP2-CAY10471
9.09Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
9.09Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
9.09Single6LPJZM2413856LPJ-A2A-ZM241385-Na
9.09Single6LPKZM2413856LPK-A2A-ZM241385-Na
9.09Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/&β;1/&γ;2
9.09Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
9.09Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
9.09Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
9.09Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
9.09Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
9.09Single8EJCTAK-8758EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
9.09Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
9.09Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/&β;1/&γ;2
9.09Consensusffa1_onOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.09Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
9.09Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
9.09Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
8.82Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
8.82Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
8.70Single4PHUFasiglifam4PHU-FFA1 (GPR40)-Fasiglifam
8.70Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
8.70Single6Z4SSR486926Z4S-NTS1-SR48692
8.70Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
8.70Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
8.70Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
8.70Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.70Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.70Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
8.70Consensusgs_sstOrthosteric Ligand7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.57Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
8.57Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
8.57Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
8.33Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
8.33Single4BV0Neurotensin4BV0-NTS1-Neurotensin
8.33Single5TZR-5TZR-FFA1 (GPR40)-MK8666
8.33Single5V56TC1145V56-SMO-TC114
8.33Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
8.33Single6OS1TRV0266OS1-AT1-TRV026
8.33Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
8.33Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1
8.33Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/&β;1/&γ;1
8.33Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
8.33Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.33Single8FMZNeurotensin/neuromedin N8FMZ-NTS1-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.33Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
8.33Consensusnts1_on_alloOrthosteric Ligand8JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
8.11Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
8.00Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
8.00Single4GRVNeurotensin 8-134GRV-NTS1-Neurotensin 8-13
8.00Single4XEENeurotensin4XEE-NTS1-Neurotensin
8.00Single4XESNeurotensin4XES-NTS1-Neurotensin
8.00Single6OS2TRV0266OS2-AT1-TRV026
8.00Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/&β;1/&γ;2
8.00Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
8.00Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.00Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.00Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
8.00Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
8.00Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
8.00Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.00Single8JPBNeurotensin 8-138JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
8.00Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
8.00Consensusnts1_offOrthosteric Ligand6Z4Q-NTS1-SR142948A 6Z4S-NTS1-SR48692
8.00Consensusnts_offOrthosteric Ligandnts1_off
8.00Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
7.69Single4BUONeurotensin4BUO-NTS1-Neurotensin
7.69Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
7.69Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
7.69Consensusclass-c_offOther Ligandgabab_off mglu_off
7.69Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.69Consensusgi_neurotensinOrthosteric Ligand7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
7.69Consensusgs_galaninOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.50Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
7.14Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
7.14Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
7.14Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
6.90Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
6.90Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
6.90Single7SHEPI; PE7SHE-GPR158-PI; PE
6.90Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.90Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
6.45Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
6.45Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
6.25Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
6.25Single8WCBCyclohexylammonium ion8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.06Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
6.06Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
6.06Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
6.06Consensusghrh_onOrthosteric Ligand7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
5.88Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
5.88Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
5.56Single7VDMSubstance P7VDM-MRGPRX2-Substance P-Gi1/&β;1/&γ;2
5.56Single7XKDBetahydroxyandrosterone7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
5.56Single7Y14Beta-alanine7Y14-MRGPRD-Beta-alanine
5.26Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
5.26Single7S8O(R)-Zinc-35737S8O-MRGPRX2-(R)-Zinc-3573-Gi1/&β;1/&γ;2
5.26Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
5.26Single7Y12Beta-alanine7Y12-MRGPRD-Beta-alanine-Gi1/&β;1/&γ;2
5.26Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
5.26Consensusgip_on_alloOther Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
5.26Consensussmo_off_alloOrthosteric Ligand6D32-SMO-Cyclopamine-Cyclopamine
5.13Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
5.00Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
5.00Single7FEEZCZ0117FEE-CB1-PubMed 104895-ZCZ011
5.00Single7S8N(R)-Zinc-35737S8N-MRGPRX2-(R)-Zinc-3573-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.00Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
5.00Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
5.00Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
5.00Consensussmo_on_alloOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
4.76Single4K5YCP-3763954K5Y-CRF1-CP-376395
4.76Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
4.76Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
4.76Single8FN0Neurotensin/neuromedin N8FN0-NTS1-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
4.76Single8U8FPML8U8F-GPR3-PML-Gs/&β;1/&γ;2
4.76Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
4.55Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
4.55Single7VV6C48/807VV6-MRGPRX2-C48/80
4.55Single8IYXYL-3658IYX-GPR34-YL-365
4.55Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
4.55Consensuscxcr_onOrthosteric Ligandcxcr1_on cxcr2_on
4.55Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
4.35Single4Z9GCP-3763954Z9G-CRF1-CP-376395
4.35Single5T04Neurotensin5T04-NTS1-Neurotensin
4.35Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
4.35Single8GTIBMK-C2058GTI-CRF1-BMK-C205
4.35Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
4.35Consensussmo_offOrthosteric Ligand5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
4.17Single4JKVTaladegib (LY2940680)4JKV-SMO-Taladegib (LY2940680)
4.17Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
4.17Single8GTGBMK-I1528GTG-CRF1-BMK-I152
4.17Single8JPCNeurotensin 8-138JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
4.17Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
4.00Single5V57TC1145V57-SMO-TC114
4.00Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
4.00Single7F1TMIP-1a7F1T-CCR5-MIP-1a
4.00Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.85Single6YVRNTS8-136YVR-NTS1-NTS8-13
3.85Single7SHEPI; PE7SHE-GPR158-PI; PE
3.85Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.85Single8GTMBMK-C2038GTM-CRF1-BMK-C203
3.85Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
3.85Consensusnts1_onOrthosteric Ligand6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
3.85Consensusnts_onOrthosteric Ligandnts1_on
3.70Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
3.70Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
3.45Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
3.33Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
2.86Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
2.78Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
2.78Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
2.70Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
2.70Single7TYIAmylin7TYI-CT-Amylin-Gs/&β;1/&γ;2
2.70Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
2.63Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
2.56Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
2.56Single8F0KPramlintide analogue san3858F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.50Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
2.50Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
2.38Single8F2APramlintide analogue san3858F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.27Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
2.22Single8F2BPramlintide analogue san458F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
2.22Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.13Single8F0JPramlintide analogue san458F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2

PDB Summary
PDB 4DJH
Class A
SubFamily Peptide
Type Opioid
SubType KOP
Species Homo sapiens
Ligand JDTic
Other Ligand(s) -
Protein Partners -
PDB Resolution 2.9
Date 2012-03-21
D.O.I. 10.1038/nature10939
Net Summary
Imin 3.77
Number of Linked Nodes 267
Number of Links 283
Number of Hubs 31
Number of Links mediated by Hubs 133
Number of Communities 6
Number of Nodes involved in Communities 33
Number of Links involved in Communities 41
Path Summary
Number Of Nodes in MetaPath 78
Number Of Links MetaPath 77
Number of Shortest Paths 56638
Length Of Smallest Path 3
Average Path Length 13.5668
Length of Longest Path 28
Minimum Path Strength 1.19
Average Path Strength 7.49317
Maximum Path Strength 23.585
Minimum Path Correlation 0.7
Average Path Correlation 0.926981
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 4.16667
Average % Of Corr. Nodes 51.1717
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 42.6738
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeJDC
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
CodeJDC
Name(3R)-7-hydroxy-N-{(2S)-1-[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]-3-methylbutan-2-yl}-1,2,3,4-tetrahydroisoquinoline-3-carboxamide
Synonyms
Identifier(3R)-N-[(2S)-1-[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-piperidin-1-yl]-3-methyl-butan-2-yl]-7-oxidanyl-1,2,3,4-tetrahydroisoquinoline-3-carboxamide
FormulaC28 H39 N3 O3
Molecular Weight465.628
SMILESC[C@H]1CN(CC[C@@]1(C)c2cccc(c2)O)C[C@H](C(C)C)NC(=O)[C@H]3Cc4ccc(cc4CN3)O
PubChem9956146
Formal Charge0
Total Atoms73
Total Chiral Atoms4
Total Bonds76
Total Aromatic Bonds12

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP41145
Sequence
>4DJH_Chain_R
SPAIPVIIT AVYSVVFVV GLVGNSLVM FVIIRYTKM KTATNIYIF 
NLALADALV TTTMPFQST VYLMNSWPF GDVLCKIVL SIDYYNMFT 
SIFTLTMMS VDRYIAVCH PVKALDFRT PLKAKIINI CIWLLSSSV 
GISAIVLGG TKVREDVDV IECSLQFPD DDYSWWDLF MKICVFIFA 
FVIPVLIII VCYTLMILR LKSVRLLSG REKDRNLRR ITRLVLVVV 
AVFVVCWTP IHIFILVEA LGSAALSSY YFCIALGYT NSSLNPILY 
AFLDENFKR CFRDFCFP


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  



This network is also present in following consensuses:
IdComponents
kop_off4DJH-κ-JDTic

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
6B73APeptideOpioidκHomo sapiensPubChem 131955138--3.12018-01-1710.1016/j.cell.2017.12.011
6VI4APeptideOpioidκHomo sapiensJDTic--3.32020-03-1810.1038/s41467-020-14889-7
7Y1FAPeptideOpioidκHomo sapiensDynorphin-Gi1/&β;1/&γ;23.32023-05-2410.1093/procel/pwac033
7YITAPeptideOpioidκHomo sapiensNalfurafine--3.32023-04-1210.1038/s41467-023-37041-7
8DZPAPeptideOpioidκHomo sapiensmomSalB-Gi1/&β;1/&γ;22.712023-05-0310.1038/s41586-023-06030-7
8DZQAPeptideOpioidκHomo sapiensmomSalB-Go/&β;1/&γ;22.822023-05-0310.1038/s41586-023-06030-7
8DZRAPeptideOpioidκHomo sapiensGR89,696-chim(NtGi2-Gt3)/&β;1/&γ;22.612023-05-0310.1038/s41586-023-06030-7
8DZSAPeptideOpioidκHomo sapiensGR89,696-chim(NtGi2-Gz)/&β;1/&γ;22.652023-05-0310.1038/s41586-023-06030-7
8F7WAPeptideOpioidκHomo sapiensDynorphin-Gi1/&β;1/&γ;23.192022-12-1410.1016/j.cell.2022.12.026
8FEGAPeptideOpioidκHomo sapiensPRD_002517-Gi1/&β;1/&γ;22.542023-12-0610.1038/s41467-023-43718-w
4DJH (Dimer)APeptideOpioidκHomo sapiensJDTic--2.92012-03-2110.1038/nature10939




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 4DJH.zip



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You can also  read or  download a guide explaining the meaning of all files and numerical data.