psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D138	17.06	Yes	No	0	0	6
2	L:L:?1	R:R:Y139	7.69	Yes	Yes	0	0	5
3	L:L:?1	R:R:M142	7.72	Yes	No	2	0	7
4	L:L:?1	R:R:S211	5.74	Yes	No	0	0	4
5	L:L:?1	R:R:W287	2.49	Yes	Yes	2	0	8
6	L:L:?1	R:R:I290	3.12	Yes	No	0	0	6
7	L:L:?1	R:R:H291	5.62	Yes	Yes	2	0	8
8	L:L:?1	R:R:I294	7.8	Yes	No	2	0	5
9	L:L:?1	R:R:E297	5.79	Yes	Yes	2	0	5
10	L:L:?1	R:R:H304	15.45	Yes	No	2	0	1
11	L:L:?1	R:R:Y312	3.84	Yes	Yes	0	0	4
12	L:L:?1	R:R:Y320	3.84	Yes	Yes	0	0	6
13	R:R:I58	R:R:P59	3.39	No	No	0	4	4
14	R:R:I58	R:R:S310	3.1	No	No	0	4	2
15	R:R:I61	R:R:I62	2.94	No	No	0	5	5
16	R:R:F314	R:R:I61	2.51	No	No	0	5	5
17	R:R:I62	R:R:Y119	25.39	No	No	8	5	4
18	R:R:I62	R:R:Y313	3.63	No	Yes	8	5	4
19	R:R:V65	R:R:V69	3.21	No	Yes	0	5	7
20	R:R:P113	R:R:Y66	2.78	No	No	0	8	6
21	R:R:S116	R:R:Y66	5.09	No	No	0	6	6
22	R:R:M112	R:R:V69	6.09	Yes	Yes	0	7	7
23	R:R:T321	R:R:V69	3.17	No	Yes	0	5	7
24	R:R:S324	R:R:V69	4.85	No	Yes	0	7	7
25	R:R:F70	R:R:L74	8.53	Yes	No	1	7	6
26	R:R:F70	R:R:T109	2.59	Yes	Yes	1	7	6
27	R:R:F70	R:R:M112	3.73	Yes	Yes	1	7	7
28	R:R:F70	R:R:P113	10.11	Yes	No	1	7	8
29	R:R:S324	R:R:V72	4.85	No	No	0	7	5
30	R:R:G73	R:R:T109	3.64	No	Yes	0	8	6
31	R:R:G73	R:R:S324	3.71	No	No	0	8	7
32	R:R:L74	R:R:T109	4.42	No	Yes	1	6	6
33	R:R:L79	R:R:V75	2.98	No	No	0	6	4
34	R:R:D105	R:R:N77	6.73	No	Yes	1	9	9
35	R:R:A106	R:R:N77	6.25	No	Yes	0	8	9
36	R:R:N77	R:R:T109	2.92	Yes	Yes	1	9	6
37	R:R:N77	R:R:P327	9.77	Yes	Yes	1	9	9
38	R:R:P327	R:R:V80	3.53	Yes	No	0	9	9
39	R:R:I84	R:R:M81	2.92	No	Yes	6	7	7
40	R:R:F99	R:R:M81	4.98	Yes	Yes	6	5	7
41	R:R:L103	R:R:M81	2.83	No	Yes	6	6	7
42	R:R:F82	R:R:R86	3.21	No	No	0	4	5
43	R:R:V83	R:R:Y87	22.71	No	Yes	0	8	5
44	R:R:I84	R:R:T88	3.04	No	Yes	0	7	6
45	R:R:F99	R:R:I84	2.51	Yes	No	6	5	7
46	R:R:I85	R:R:R86	6.26	No	No	0	3	5
47	R:R:T88	R:R:Y87	4.99	Yes	Yes	0	6	5
48	R:R:F337	R:R:Y87	11.35	Yes	Yes	0	8	5
49	R:R:C340	R:R:Y87	8.06	No	Yes	0	6	5
50	R:R:F341	R:R:Y87	5.16	No	Yes	0	6	5
51	R:R:K89	R:R:T88	3	No	Yes	0	5	6
52	R:R:N95	R:R:T88	2.92	No	Yes	0	7	6
53	R:R:K89	R:R:K91	12.93	No	No	0	5	7
54	R:R:I96	R:R:M90	4.37	Yes	No	0	5	7
55	R:R:F99	R:R:M90	6.22	Yes	No	0	5	7
56	R:R:T92	R:R:T94	3.14	No	No	0	7	8
57	R:R:N95	R:R:T92	5.85	No	No	0	7	7
58	R:R:F337	R:R:N95	2.42	Yes	No	0	8	7
59	R:R:I96	R:R:Y97	6.04	Yes	Yes	4	5	7
60	R:R:I96	R:R:N179	2.83	Yes	Yes	4	5	7
61	R:R:M152	R:R:Y97	3.59	No	Yes	0	8	7
62	R:R:A175	R:R:Y97	2.67	No	Yes	0	7	7
63	R:R:N179	R:R:Y97	4.65	Yes	Yes	4	7	7
64	R:R:I98	R:R:Y330	4.84	No	Yes	0	8	9
65	R:R:F337	R:R:I98	2.51	Yes	No	0	8	8
66	R:R:F99	R:R:L103	8.53	Yes	No	6	5	6
67	R:R:N100	R:R:N179	14.98	No	Yes	4	9	7
68	R:R:N100	R:R:W183	11.3	No	Yes	4	9	9
69	R:R:L101	R:R:T148	2.95	Yes	No	0	9	7
70	R:R:L101	R:R:L149	5.54	Yes	No	0	9	8
71	R:R:L101	R:R:N326	5.49	Yes	Yes	0	9	9
72	R:R:L101	R:R:Y330	3.52	Yes	Yes	0	9	9
73	R:R:A104	R:R:N141	3.13	No	No	0	8	8
74	R:R:D105	R:R:N326	12.12	No	Yes	1	9	9
75	R:R:D105	R:R:P327	6.44	No	Yes	1	9	9
76	R:R:L107	R:R:N141	2.75	No	No	0	6	8
77	R:R:T111	R:R:V108	3.17	No	Yes	0	7	7
78	R:R:N141	R:R:V108	5.91	No	Yes	0	8	7
79	R:R:S323	R:R:V108	6.46	No	Yes	0	8	7
80	R:R:M112	R:R:P113	3.35	Yes	No	1	7	8
81	R:R:M112	R:R:Y320	19.16	Yes	Yes	0	7	6
82	R:R:Q115	R:R:Y312	5.64	No	Yes	0	7	4
83	R:R:Q115	R:R:Y320	10.15	No	Yes	0	7	6
84	R:R:F126	R:R:T117	7.78	Yes	No	0	7	4
85	R:R:F126	R:R:V118	2.62	Yes	No	0	7	5
86	R:R:L120	R:R:Y119	15.24	No	No	0	4	4
87	R:R:Y119	R:R:Y313	19.86	No	Yes	8	4	4
88	R:R:S123	R:R:V207	4.85	No	No	10	4	3
89	R:R:E209	R:R:S123	4.31	No	No	10	3	4
90	R:R:F126	R:R:W124	4.01	Yes	Yes	0	7	8
91	R:R:G127	R:R:W124	2.81	No	Yes	0	7	8
92	R:R:T199	R:R:W124	4.85	Yes	Yes	7	4	8
93	R:R:I208	R:R:W124	9.4	No	Yes	7	4	8
94	R:R:C210	R:R:W124	13.06	No	Yes	7	9	8
95	R:R:F126	R:R:L130	4.87	Yes	No	0	7	5
96	R:R:D128	R:R:V129	4.38	No	No	0	2	1
97	R:R:D128	R:R:T199	2.89	No	Yes	0	2	4
98	R:R:C131	R:R:C210	7.28	No	No	0	9	9
99	R:R:G198	R:R:K132	6.97	No	No	0	4	6
100	R:R:I133	R:R:I137	2.94	No	No	0	5	5
101	R:R:I135	R:R:Y139	3.63	No	Yes	0	4	5
102	R:R:I194	R:R:S136	3.1	Yes	No	0	4	5
103	R:R:F143	R:R:Y139	5.16	Yes	Yes	0	6	5
104	R:R:A193	R:R:Y139	2.67	No	Yes	0	5	5
105	R:R:W183	R:R:Y140	7.72	Yes	No	0	9	5
106	R:R:S186	R:R:Y140	2.54	No	No	0	8	5
107	R:R:S187	R:R:Y140	2.54	No	No	0	4	5
108	R:R:F143	R:R:M142	6.22	Yes	No	0	6	7
109	R:R:M142	R:R:W287	3.49	No	Yes	2	7	8
110	R:R:F143	R:R:S186	2.64	Yes	No	0	6	8
111	R:R:F143	R:R:V189	6.55	Yes	No	0	6	5
112	R:R:F143	R:R:V230	2.62	Yes	No	0	6	5
113	R:R:T144	R:R:W183	16.98	No	Yes	0	7	9
114	R:R:S186	R:R:T144	4.8	No	No	0	8	7
115	R:R:I146	R:R:P238	3.39	No	No	0	7	9
116	R:R:F147	R:R:T150	2.59	No	No	0	6	7
117	R:R:F147	R:R:I182	2.51	No	No	0	6	7
118	R:R:T148	R:R:W183	2.43	No	Yes	0	7	9
119	R:R:L149	R:R:M152	2.83	No	No	0	8	8
120	R:R:P238	R:R:T150	3.5	No	No	0	9	7
121	R:R:I178	R:R:M151	4.37	No	No	0	6	6
122	R:R:I182	R:R:M151	5.83	No	No	0	7	6
123	R:R:M152	R:R:Y330	3.59	No	Yes	0	8	9
124	R:R:I242	R:R:S153	9.29	No	No	5	8	9
125	R:R:C245	R:R:S153	3.44	Yes	No	0	7	9
126	R:R:S153	R:R:Y246	15.26	No	Yes	5	9	8
127	R:R:D155	R:R:R170	16.68	No	No	0	8	6
128	R:R:R156	R:R:Y246	3.09	No	Yes	5	9	8
129	R:R:M249	R:R:R156	7.44	No	No	5	8	9
130	R:R:C161	R:R:Y157	9.41	No	Yes	0	7	7
131	R:R:H162	R:R:Y157	8.71	No	Yes	0	6	7
132	R:R:C245	R:R:Y157	6.72	Yes	Yes	0	7	7
133	R:R:L248	R:R:Y157	3.52	No	Yes	0	4	7
134	R:R:H162	R:R:I158	3.98	No	No	0	6	5
135	R:R:F169	R:R:I158	5.02	No	No	0	4	5
136	R:R:A159	R:R:R170	4.15	No	No	0	8	6
137	R:R:M249	R:R:V160	7.61	No	No	0	8	8
138	R:R:L253	R:R:V160	2.98	Yes	No	0	8	8
139	R:R:C161	R:R:R252	5.57	No	No	0	7	5
140	R:R:H162	R:R:K165	2.62	No	No	0	6	4
141	R:R:P163	R:R:V164	3.53	No	No	0	8	5
142	R:R:K165	R:R:V164	3.04	No	No	0	4	5
143	R:R:A166	R:R:R170	2.77	No	No	0	5	6
144	R:R:F169	R:R:K174	3.72	No	No	0	4	5
145	R:R:I178	R:R:K174	2.91	No	No	0	6	5
146	R:R:N179	R:R:W183	9.04	Yes	Yes	4	7	9
147	R:R:I182	R:R:W183	2.35	No	Yes	0	7	9
148	R:R:S188	R:R:V189	3.23	No	No	0	4	5
149	R:R:S192	R:R:V189	3.23	No	No	0	7	5
150	R:R:I191	R:R:I194	2.94	No	Yes	0	4	4
151	R:R:F214	R:R:L196	9.74	No	No	0	6	4
152	R:R:I208	R:R:T199	3.04	No	Yes	7	4	4
153	R:R:C210	R:R:T199	3.38	No	Yes	7	9	4
154	R:R:K200	R:R:Q213	4.07	No	Yes	0	2	4
155	R:R:I208	R:R:V201	4.61	No	No	0	4	2
156	R:R:D204	R:R:R202	3.57	No	No	0	2	2
157	R:R:E209	R:R:R202	23.26	No	No	0	3	2
158	R:R:D204	R:R:V205	5.84	No	No	0	2	1
159	R:R:V205	R:R:V207	6.41	No	No	0	1	3
160	R:R:E209	R:R:V207	5.7	No	No	10	3	3
161	R:R:L212	R:R:S211	6.01	No	No	0	4	4
162	R:R:F214	R:R:L212	6.09	No	No	0	6	4
163	R:R:F214	R:R:M226	2.49	No	No	0	6	5
164	R:R:D217	R:R:P215	6.44	No	No	3	1	5
165	R:R:D218	R:R:P215	3.22	No	No	3	4	5
166	R:R:D216	R:R:Y219	3.45	No	No	0	2	1
167	R:R:D217	R:R:D218	13.31	No	No	3	1	4
168	R:R:D218	R:R:W222	7.82	No	No	0	4	7
169	R:R:I294	R:R:K227	7.27	No	No	0	5	4
170	R:R:A298	R:R:K227	4.82	No	No	0	4	4
171	R:R:C229	R:R:F233	2.79	No	No	0	3	4
172	R:R:F231	R:R:H291	6.79	No	Yes	0	5	8
173	R:R:F231	R:R:L295	8.53	No	No	0	5	5
174	R:R:F233	R:R:I232	5.02	No	No	0	4	5
175	R:R:I232	R:R:V236	6.14	No	No	0	5	4
176	R:R:F235	R:R:V239	6.55	No	No	0	8	6
177	R:R:F235	R:R:T288	6.49	No	No	0	8	5
178	R:R:F235	R:R:H291	5.66	No	Yes	0	8	8
179	R:R:I237	R:R:P238	3.39	No	No	0	5	9
180	R:R:F283	R:R:V239	2.62	No	No	0	9	6
181	R:R:I242	R:R:Y246	7.25	No	Yes	5	8	8
182	R:R:M249	R:R:Y246	3.59	No	Yes	5	8	8
183	R:R:V276	R:R:Y246	7.57	No	Yes	0	8	8
184	R:R:V280	R:R:Y246	2.52	No	Yes	0	8	8
185	R:R:I250	R:R:T273	6.08	No	No	0	5	6
186	R:R:L251	R:R:R252	7.29	No	No	0	4	5
187	R:R:R252	R:R:S255	7.91	No	No	0	5	4
188	R:R:L253	R:R:L269	5.54	Yes	Yes	11	8	6
189	R:R:K254	R:R:L269	5.64	No	Yes	0	4	6
190	R:R:L258	R:R:L259	4.15	No	No	0	5	3
191	R:R:K265	R:R:L258	2.82	No	No	0	4	5
192	R:R:D266	R:R:G261	6.71	No	No	0	3	3
193	R:R:K265	R:R:S262	10.71	No	No	0	4	1
194	R:R:E264	R:R:R267	6.98	No	No	0	3	4
195	R:R:R267	R:R:R270	5.33	No	No	0	4	5
196	R:R:I272	R:R:L269	2.85	No	Yes	0	7	6
197	R:R:L275	R:R:L333	2.77	No	No	0	8	7
198	R:R:V279	R:R:Y330	5.05	No	Yes	0	8	9
199	R:R:F283	R:R:W287	8.02	No	Yes	0	9	8
200	R:R:T288	R:R:V284	3.17	No	No	0	5	6
201	R:R:C286	R:R:N322	11.02	No	Yes	0	8	9
202	R:R:H291	R:R:W287	3.17	Yes	Yes	2	8	8
203	R:R:N322	R:R:W287	5.65	Yes	Yes	0	9	8
204	R:R:P289	R:R:T288	5.25	No	No	0	9	5
205	R:R:C315	R:R:I290	4.91	No	No	0	7	6
206	R:R:E297	R:R:F293	11.66	Yes	No	0	5	5
207	R:R:E297	R:R:I294	4.1	Yes	No	2	5	5
208	R:R:L295	R:R:L299	5.54	No	No	0	5	4
209	R:R:T302	R:R:V296	4.76	No	No	0	1	4
210	R:R:E297	R:R:T302	2.82	Yes	No	0	5	1
211	R:R:E297	R:R:H304	4.92	Yes	No	2	5	1
212	R:R:A308	R:R:H304	4.39	No	No	0	3	1
213	R:R:F314	R:R:S310	2.64	No	No	0	5	2
214	R:R:Y312	R:R:Y313	6.95	Yes	Yes	0	4	4
215	R:R:I316	R:R:Y312	8.46	No	Yes	0	5	4
216	R:R:I316	R:R:Y320	4.84	No	Yes	0	5	6
217	R:R:N322	R:R:N326	2.72	Yes	Yes	0	9	9
218	R:R:N326	R:R:P327	4.89	Yes	Yes	1	9	9
219	R:R:L329	R:R:Y330	4.69	No	Yes	0	8	9
220	R:R:L329	R:R:L333	4.15	No	No	0	8	7
221	R:R:F332	R:R:L333	2.44	No	No	0	6	7
222	R:R:F332	R:R:K338	2.48	No	No	0	6	8
223	R:R:D334	R:R:N336	13.46	No	No	9	8	6
224	R:R:D334	R:R:F337	9.55	No	Yes	9	8	8
225	R:R:F337	R:R:N336	12.08	Yes	No	9	8	6
226	R:R:R267	R:R:R271	2.13	No	No	0	4	7
227	R:R:G197	R:R:G198	2.11	No	No	3	4	4
228	R:R:A193	R:R:G190	1.95	No	No	0	5	6
229	R:R:G190	R:R:S136	1.86	No	No	0	6	5
230	R:R:G300	R:R:S301	1.86	No	No	0	2	2
231	R:R:G76	R:R:V75	1.84	No	No	0	7	4
232	R:R:A175	R:R:A93	1.79	No	No	0	7	6
233	R:R:G76	R:R:I328	1.76	No	No	0	7	7
234	R:R:P172	R:R:T171	1.75	No	No	0	2	7
235	R:R:A104	R:R:S145	1.71	No	No	0	8	9
236	R:R:C245	R:R:V154	1.71	Yes	No	0	7	6
237	R:R:C286	R:R:V285	1.71	No	No	0	8	6
238	R:R:G300	R:R:L299	1.71	No	No	0	2	4
239	R:R:A307	R:R:S305	1.71	No	No	0	4	3
240	R:R:A308	R:R:S311	1.71	No	No	0	3	4
241	R:R:G319	R:R:L318	1.71	No	No	0	7	8
242	R:R:A102	R:R:V80	1.7	No	No	0	8	9
243	R:R:A331	R:R:V80	1.7	No	No	0	7	9
244	R:R:G319	R:R:N322	1.7	No	Yes	0	7	9
245	R:R:C131	R:R:I135	1.64	No	No	0	9	4
246	R:R:G197	R:R:Q213	1.64	No	Yes	3	4	4
247	R:R:G198	R:R:Q213	1.64	No	Yes	3	4	4
248	R:R:C245	R:R:I241	1.64	Yes	No	0	7	6
249	L:L:?1	R:R:V108	1.63	Yes	Yes	0	0	7
250	R:R:S301	R:R:S303	1.63	No	No	0	2	1
251	R:R:A64	R:R:I61	1.62	No	No	0	5	5
252	R:R:A234	R:R:I146	1.62	No	No	0	6	7
253	R:R:S255	R:R:V256	1.62	No	No	0	4	6
254	R:R:V68	R:R:V72	1.6	No	No	0	5	5
255	R:R:V71	R:R:V75	1.6	No	No	0	5	4
256	R:R:V278	R:R:V282	1.6	No	No	0	5	7
257	R:R:P215	R:R:Q213	1.58	No	Yes	3	5	4
258	R:R:I133	R:R:V129	1.54	No	No	0	5	1
259	R:R:I194	R:R:V195	1.54	Yes	No	0	4	4
260	R:R:I243	R:R:V239	1.54	No	No	0	5	6
261	R:R:I243	R:R:V280	1.54	No	No	0	5	8
262	R:R:I292	R:R:V296	1.54	No	No	0	5	4
263	R:R:L79	R:R:S78	1.5	No	No	0	6	4
264	R:R:K174	R:R:T171	1.5	No	No	0	5	7
265	R:R:L184	R:R:S187	1.5	No	No	0	4	4
266	R:R:L185	R:R:S188	1.5	No	No	0	4	4
267	R:R:L224	R:R:S220	1.5	No	No	0	3	2
268	R:R:L240	R:R:V244	1.49	No	No	0	3	4
269	R:R:L329	R:R:V282	1.49	No	No	0	8	7
270	R:R:I177	R:R:I178	1.47	No	No	0	3	6
271	R:R:L325	R:R:T321	1.47	No	No	0	6	5
272	R:R:D155	R:R:T94	1.45	No	No	0	8	8
273	R:R:I96	R:R:K176	1.45	Yes	No	0	5	4
274	R:R:I194	R:R:K132	1.45	Yes	No	0	4	6
275	R:R:F126	R:R:P125	1.44	Yes	No	0	7	1
276	R:R:I180	R:R:L184	1.43	No	No	0	4	4
277	R:R:I241	R:R:L240	1.43	No	No	0	6	3
278	R:R:I250	R:R:L253	1.43	No	Yes	0	5	8
279	R:R:L224	R:R:L299	1.38	No	No	0	3	4
280	R:R:L253	R:R:L259	1.38	Yes	No	11	8	3
281	R:R:D266	R:R:K254	1.38	No	No	0	3	4
282	R:R:L259	R:R:L269	1.38	No	Yes	11	3	6
283	R:R:D168	R:R:L167	1.36	No	No	0	4	5
284	R:R:D223	R:R:L212	1.36	No	No	0	4	4
285	R:R:E335	R:R:K338	1.35	No	No	0	4	8
286	R:R:F114	R:R:V134	1.31	No	No	0	5	6
287	R:R:F231	R:R:V236	1.31	No	No	0	5	4
288	R:R:S67	R:R:Y66	1.27	No	No	0	4	6
289	R:R:F82	R:R:M81	1.24	No	Yes	0	4	7
290	R:R:S220	R:R:W221	1.24	No	No	0	2	1
291	R:R:F114	R:R:L130	1.22	No	No	0	5	5
292	R:R:N122	R:R:Y313	1.16	No	Yes	0	5	4
293	R:R:E264	R:R:R263	1.16	No	No	0	3	3
294	R:R:R271	R:R:R274	1.07	No	No	0	7	6
295	R:R:F225	R:R:W222	1	No	No	0	4	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	6.75308	13	2	0
2	R:R:V69	4.33	4	0	7
3	R:R:F70	6.24	4	1	7
4	R:R:N77	6.4175	4	1	9
5	R:R:M81	2.9925	4	6	7
6	R:R:Y87	10.454	5	0	5
7	R:R:T88	3.4875	4	0	6
8	R:R:I96	3.6725	4	4	5
9	R:R:Y97	4.2375	4	4	7
10	R:R:F99	5.56	4	6	5
11	R:R:L101	4.375	4	0	9
12	R:R:V108	4.2925	4	0	7
13	R:R:T109	3.3925	4	1	6
14	R:R:M112	8.0825	4	1	7
15	R:R:W124	6.826	5	7	8
16	R:R:F126	4.144	5	0	7
17	R:R:Y139	4.7875	4	0	5
18	R:R:F143	4.638	5	0	6
19	R:R:Y157	7.09	4	0	7
20	R:R:N179	7.875	4	4	7
21	R:R:W183	8.30333	6	4	9
22	R:R:I194	2.2575	4	0	4
23	R:R:T199	3.54	4	7	4
24	R:R:Q213	2.2325	4	3	4
25	R:R:C245	3.3775	4	0	7
26	R:R:Y246	6.54667	6	5	8
27	R:R:L253	2.8325	4	11	8
28	R:R:L269	3.8525	4	11	6
29	R:R:W287	4.564	5	2	8
30	R:R:H291	5.31	4	2	8
31	R:R:E297	5.858	5	2	5
32	R:R:Y312	6.2225	4	0	4
33	R:R:Y313	7.9	4	8	4
34	R:R:Y320	9.4975	4	0	6
35	R:R:N322	5.2725	4	0	9
36	R:R:N326	6.305	4	1	9
37	R:R:P327	6.1575	4	1	9
38	R:R:Y330	4.338	5	0	9
39	R:R:F337	7.582	5	9	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y312	34.2686	3.84	Yes	Yes	0	0	4
2	R:R:Y312	R:R:Y313	30.4105	6.95	Yes	Yes	0	4	4
3	R:R:I62	R:R:Y313	19.622	3.63	No	Yes	8	5	4
4	R:R:I61	R:R:I62	17.1278	2.94	No	No	0	5	5
5	R:R:F314	R:R:I61	11.464	2.51	No	No	0	5	5
6	L:L:?1	R:R:Y320	38.3866	3.84	Yes	Yes	0	0	6
7	R:R:M112	R:R:Y320	34.8922	19.16	Yes	Yes	0	7	6
8	R:R:M112	R:R:V69	19.1413	6.09	Yes	Yes	0	7	7
9	R:R:P113	R:R:Y66	10.847	2.78	No	No	0	8	6
10	R:R:F70	R:R:M112	10.3988	3.73	Yes	Yes	1	7	7
11	R:R:F70	R:R:T109	14.0881	2.59	Yes	Yes	1	7	6
12	R:R:G73	R:R:T109	10.1195	3.64	No	Yes	0	8	6
13	L:L:?1	R:R:W287	56.6771	2.49	Yes	Yes	2	0	8
14	R:R:N322	R:R:W287	64.6207	5.65	Yes	Yes	0	9	8
15	R:R:N322	R:R:N326	63.2892	2.72	Yes	Yes	0	9	9
16	R:R:D105	R:R:N326	15.478	12.12	No	Yes	1	9	9
17	R:R:D105	R:R:N77	13.9582	6.73	No	Yes	1	9	9
18	R:R:N326	R:R:P327	20.5248	4.89	Yes	Yes	1	9	9
19	R:R:N77	R:R:P327	14.4453	9.77	Yes	Yes	1	9	9
20	R:R:N77	R:R:T109	23.3697	2.92	Yes	Yes	1	9	6
21	L:L:?1	R:R:Y139	84.5674	7.69	Yes	Yes	0	0	5
22	R:R:F143	R:R:Y139	56.2873	5.16	Yes	Yes	0	6	5
23	R:R:F143	R:R:S186	100	2.64	Yes	No	0	6	8
24	R:R:S186	R:R:Y140	52.1239	2.54	No	No	0	8	5
25	R:R:W183	R:R:Y140	48.3048	7.72	Yes	No	0	9	5
26	R:R:N179	R:R:W183	49.6298	9.04	Yes	Yes	4	7	9
27	R:R:I96	R:R:N179	38.8932	2.83	Yes	Yes	4	5	7
28	R:R:I96	R:R:M90	39.5687	4.37	Yes	No	0	5	7
29	R:R:F99	R:R:M90	34.8142	6.22	Yes	No	0	5	7
30	L:L:?1	R:R:M142	34.0933	7.72	Yes	No	2	0	7
31	R:R:F143	R:R:M142	50.0779	6.22	Yes	No	0	6	7
32	R:R:S186	R:R:T144	47.311	4.8	No	No	0	8	7
33	R:R:T144	R:R:W183	46.3562	16.98	No	Yes	0	7	9
34	R:R:L101	R:R:N326	78.6243	5.49	Yes	Yes	0	9	9
35	R:R:L101	R:R:Y330	61.8537	3.52	Yes	Yes	0	9	9
36	R:R:I98	R:R:Y330	40.0429	4.84	No	Yes	0	8	9
37	R:R:F337	R:R:I98	38.5685	2.51	Yes	No	0	8	8
38	R:R:F337	R:R:Y87	14.7961	11.35	Yes	Yes	0	8	5
39	R:R:I84	R:R:T88	10.8405	3.04	No	Yes	0	7	6
40	R:R:F337	R:R:N95	19.8038	2.42	Yes	No	0	8	7
41	R:R:F99	R:R:M81	19.7389	4.98	Yes	Yes	6	5	7
42	R:R:F82	R:R:M81	18.7581	1.24	No	Yes	0	4	7
43	R:R:F82	R:R:R86	12.5162	3.21	No	No	0	4	5
44	R:R:N95	R:R:T92	11.2042	5.85	No	No	0	7	7
45	R:R:L101	R:R:L149	10.5482	5.54	Yes	No	0	9	8
46	R:R:M152	R:R:Y97	17.4721	3.59	No	Yes	0	8	7
47	R:R:M152	R:R:Y330	10.5612	3.59	No	Yes	0	8	9
48	R:R:L101	R:R:T148	22.2525	2.95	Yes	No	0	9	7
49	L:L:?1	R:R:V108	18.0956	1.63	Yes	Yes	0	0	7
50	R:R:N141	R:R:V108	10.4897	5.91	No	Yes	0	8	7
51	R:R:I135	R:R:Y139	43.219	3.63	No	Yes	0	4	5
52	R:R:C131	R:R:I135	41.4523	1.64	No	No	0	9	4
53	R:R:C131	R:R:C210	39.4843	7.28	No	No	0	9	9
54	R:R:C210	R:R:W124	22.7592	13.06	No	Yes	7	9	8
55	R:R:F126	R:R:W124	14.9325	4.01	Yes	Yes	0	7	8
56	R:R:C210	R:R:T199	14.7246	3.38	No	Yes	7	9	4
57	R:R:A193	R:R:Y139	33.5152	2.67	No	Yes	0	5	5
58	R:R:A193	R:R:G190	31.6706	1.95	No	No	0	5	6
59	R:R:G190	R:R:S136	29.6376	1.86	No	No	0	6	5
60	R:R:I194	R:R:S136	27.5916	3.1	Yes	No	0	4	5
61	R:R:I194	R:R:K132	21.3757	1.45	Yes	No	0	4	6
62	R:R:G198	R:R:K132	19.2777	6.97	No	No	0	4	6
63	R:R:F143	R:R:V189	11.3471	6.55	Yes	No	0	6	5
64	R:R:I182	R:R:W183	58.2294	2.35	No	Yes	0	7	9
65	R:R:F147	R:R:I182	22.7137	2.51	No	No	0	6	7
66	R:R:F147	R:R:T150	18.9595	2.59	No	No	0	6	7
67	R:R:P238	R:R:T150	15.1923	3.5	No	No	0	9	7
68	R:R:I182	R:R:M151	35.6781	5.83	No	No	0	7	6
69	R:R:I178	R:R:M151	32.424	4.37	No	No	0	6	6
70	R:R:F283	R:R:W287	49.8051	8.02	No	Yes	0	9	8
71	R:R:F283	R:R:V239	48.1943	2.62	No	No	0	9	6
72	R:R:I243	R:R:V239	75.2208	1.54	No	No	0	5	6
73	R:R:I243	R:R:V280	73.006	1.54	No	No	0	5	8
74	R:R:V280	R:R:Y246	70.7781	2.52	No	Yes	0	8	8
75	L:L:?1	R:R:H291	51.0717	5.62	Yes	Yes	2	0	8
76	R:R:F235	R:R:H291	38.9062	5.66	No	Yes	0	8	8
77	R:R:F235	R:R:V239	29.3193	6.55	No	No	0	8	6
78	R:R:S153	R:R:Y246	32.9761	15.26	No	Yes	5	9	8
79	R:R:C245	R:R:S153	31.5082	3.44	Yes	No	0	7	9
80	R:R:M249	R:R:Y246	35.3988	3.59	No	Yes	5	8	8
81	R:R:C245	R:R:Y157	23.3242	6.72	Yes	Yes	0	7	7
82	R:R:C161	R:R:Y157	11.3276	9.41	No	Yes	0	7	7
83	R:R:H162	R:R:Y157	14.2764	8.71	No	Yes	0	6	7
84	R:R:I178	R:R:K174	25.9418	2.91	No	No	0	6	5
85	R:R:F169	R:R:K174	16.251	3.72	No	No	0	4	5
86	R:R:F169	R:R:I158	13.7958	5.02	No	No	0	4	5
87	R:R:H162	R:R:I158	12.198	3.98	No	No	0	6	5
88	R:R:M249	R:R:V160	32.9956	7.61	No	No	0	8	8
89	R:R:L253	R:R:V160	30.4754	2.98	Yes	No	0	8	8
90	L:L:?1	R:R:S211	14.9844	5.74	Yes	No	0	0	4
91	R:R:L212	R:R:S211	12.6202	6.01	No	No	0	4	4
92	R:R:G198	R:R:Q213	14.9974	1.64	No	Yes	3	4	4
93	R:R:P215	R:R:Q213	10.756	1.58	No	Yes	3	5	4
94	R:R:F231	R:R:H291	37.9449	6.79	No	Yes	0	5	8
95	R:R:F231	R:R:V236	11.9706	1.31	No	No	0	5	4
96	R:R:F231	R:R:L295	23.5191	8.53	No	No	0	5	5
97	R:R:L253	R:R:L269	12.7371	5.54	Yes	Yes	11	8	6
98	R:R:L253	R:R:L259	10.4378	1.38	Yes	No	11	8	3
99	R:R:L329	R:R:Y330	15.1273	4.69	No	Yes	0	8	9
100	L:L:?1	R:R:E297	12.6591	5.79	Yes	Yes	2	0	5
101	R:R:L295	R:R:L299	20.5963	5.54	No	No	0	5	4
102	R:R:T148	R:R:W183	21.9992	2.43	No	Yes	0	7	9
103	R:R:H291	R:R:W287	20.6612	3.17	Yes	Yes	2	8	8
104	R:R:M142	R:R:W287	16.6082	3.49	No	Yes	2	7	8
105	R:R:I96	R:R:Y97	10.2559	6.04	Yes	Yes	4	5	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:D138	17.06	2	Yes	No	0	6	0	1
L:L:?1	R:R:Y139	7.69	2	Yes	Yes	0	5	0	1
L:L:?1	R:R:M142	7.72	2	Yes	No	0	7	0	1
L:L:?1	R:R:S211	5.74	2	Yes	No	0	4	0	1
L:L:?1	R:R:W287	2.49	2	Yes	Yes	0	8	0	1
L:L:?1	R:R:I290	3.12	2	Yes	No	0	6	0	1
L:L:?1	R:R:H291	5.62	2	Yes	Yes	0	8	0	1
L:L:?1	R:R:I294	7.8	2	Yes	No	0	5	0	1
L:L:?1	R:R:E297	5.79	2	Yes	Yes	0	5	0	1
L:L:?1	R:R:H304	15.45	2	Yes	No	0	1	0	1
L:L:?1	R:R:Y312	3.84	2	Yes	Yes	0	4	0	1
L:L:?1	R:R:Y320	3.84	2	Yes	Yes	0	6	0	1
R:R:T111	R:R:V108	3.17	0	No	Yes	7	7	2	1
R:R:N141	R:R:V108	5.91	0	No	Yes	8	7	2	1
R:R:S323	R:R:V108	6.46	0	No	Yes	8	7	2	1
R:R:M112	R:R:Y320	19.16	1	Yes	Yes	7	6	2	1
R:R:Q115	R:R:Y312	5.64	0	No	Yes	7	4	2	1
R:R:Q115	R:R:Y320	10.15	0	No	Yes	7	6	2	1
R:R:I135	R:R:Y139	3.63	0	No	Yes	4	5	2	1
R:R:F143	R:R:Y139	5.16	0	Yes	Yes	6	5	2	1
R:R:A193	R:R:Y139	2.67	0	No	Yes	5	5	2	1
R:R:F143	R:R:M142	6.22	0	Yes	No	6	7	2	1
R:R:M142	R:R:W287	3.49	2	No	Yes	7	8	1	1
R:R:L212	R:R:S211	6.01	0	No	No	4	4	2	1
R:R:I294	R:R:K227	7.27	2	No	No	5	4	1	2
R:R:F231	R:R:H291	6.79	0	No	Yes	5	8	2	1
R:R:F235	R:R:H291	5.66	0	No	Yes	8	8	2	1
R:R:F283	R:R:W287	8.02	0	No	Yes	9	8	2	1
R:R:H291	R:R:W287	3.17	2	Yes	Yes	8	8	1	1
R:R:N322	R:R:W287	5.65	0	Yes	Yes	9	8	2	1
R:R:C315	R:R:I290	4.91	0	No	No	7	6	2	1
R:R:E297	R:R:F293	11.66	2	Yes	No	5	5	1	2
R:R:E297	R:R:I294	4.1	2	Yes	No	5	5	1	1
R:R:E297	R:R:T302	2.82	2	Yes	No	5	1	1	2
R:R:E297	R:R:H304	4.92	2	Yes	No	5	1	1	1
R:R:A308	R:R:H304	4.39	0	No	No	3	1	2	1
R:R:Y312	R:R:Y313	6.95	0	Yes	Yes	4	4	1	2
R:R:I316	R:R:Y312	8.46	0	No	Yes	5	4	2	1
R:R:I316	R:R:Y320	4.84	0	No	Yes	5	6	2	1
L:L:?1	R:R:V108	1.63	2	Yes	Yes	0	7	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8VVE_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.35
Number of Linked Nodes	266
Number of Links	295
Number of Hubs	39
Number of Links mediated by Hubs	145
Number of Communities	11
Number of Nodes involved in Communities	52
Number of Links involved in Communities	63

Path Summary
Number Of Nodes in MetaPath	106
Number Of Links MetaPath	105
Number of Shortest Paths	52227
Length Of Smallest Path	3
Average Path Length	12.3101
Length of Longest Path	26
Minimum Path Strength	1.37
Average Path Strength	4.94697
Maximum Path Strength	20.315
Minimum Path Correlation	0.7
Average Path Correlation	0.924665
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5
Average % Of Corr. Nodes	50.4074
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	45.1683
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	A1A
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	A1A
Name	6-AMINO HEXANOIC ACID
Synonyms
Identifier
Formula	C33 H40 N4 O6
Molecular Weight	588.694
SMILES
PubChem	5327090
Formal Charge	0
Total Atoms	83
Total Chiral Atoms	4
Total Bonds	86
Total Aromatic Bonds	18


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P41145
Sequence	>8VVE_nogp_Chain_R A I P V I I T A V Y S V V F V V G L V G N S L V M F V I I R Y T K M K T A T N I Y I F N L A L A D A L V T T T M P F Q S T V Y L M N S W P F G D V L C K I V I S I D Y Y N M F T S I F T L T M M S V D R Y I A V C H P V K A L D F R T P L K A K I I N I C I W L L S S S V G I S A I V L G G T K V R E D V D V I E C S L Q F P D D D Y S W W D L F M K I C V F I F A F V I P V L I I I V C Y T L M I L R L K S V R L L S G S R E K D R N L R R I T R L V L V V V A V F V V C W T P I H I F I L V E A L G S T S H S T A A L S S Y Y F C I A L G Y T N S S L N P I L Y A F L D E N F K R C F R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6B73	A	Peptide	Opioid	κ	Homo sapiens	MP1104	-	-	3.1	2018-01-17	doi.org/10.1016/j.cell.2017.12.011
	8F7W	A	Peptide	Opioid	κ	Homo sapiens	Dynorphin	-	Gi1/β1/γ2	3.19	2022-12-14	doi.org/10.1016/j.cell.2022.12.026
	8F7W (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	Dynorphin	-		3.19	2022-12-14	doi.org/10.1016/j.cell.2022.12.026
	4DJH	A	Peptide	Opioid	κ	Homo sapiens	JDTic	-	-	2.9	2012-03-21	doi.org/10.1038/nature10939
	6VI4	A	Peptide	Opioid	κ	Homo sapiens	JDTic	-	-	3.3	2020-03-18	doi.org/10.1038/s41467-020-14889-7
	7YIT	A	Peptide	Opioid	κ	Homo sapiens	Nalfurafine	-	-	3.3	2023-04-12	doi.org/10.1038/s41467-023-37041-7
	8FEG	A	Peptide	Opioid	κ	Homo sapiens	(DNCP)-β-Naloxamine	-	Gi1/β1/γ2	2.54	2023-12-06	doi.org/10.1038/s41467-023-43718-w
	8FEG (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	(DNCP)-β-Naloxamine	-		2.54	2023-12-06	doi.org/10.1038/s41467-023-43718-w
	8DZP	A	Peptide	Opioid	κ	Homo sapiens	momSalB	-	Gi1/β1/γ2	2.71	2023-05-03	doi.org/10.1038/s41586-023-06030-7
	8DZP (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	momSalB	-		2.71	2023-05-03	doi.org/10.1038/s41586-023-06030-7
	8DZQ	A	Peptide	Opioid	κ	Homo sapiens	momSalB	-	Go/β1/γ2	2.82	2023-05-03	doi.org/10.1038/s41586-023-06030-7
	8DZQ (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	momSalB	-		2.82	2023-05-03	doi.org/10.1038/s41586-023-06030-7
	8DZR	A	Peptide	Opioid	κ	Homo sapiens	GR89,696	-	chim(NtGi2-Gt3)/β1/γ2	2.61	2023-05-03	doi.org/10.1038/s41586-023-06030-7
	8DZR (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	GR89,696	-		2.61	2023-05-03	doi.org/10.1038/s41586-023-06030-7
	8DZS	A	Peptide	Opioid	κ	Homo sapiens	GR89,696	-	chim(NtGi2-Gz)/β1/γ2	2.65	2023-05-03	doi.org/10.1038/s41586-023-06030-7
	8DZS (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	GR89,696	-		2.65	2023-05-03	doi.org/10.1038/s41586-023-06030-7
	7Y1F	A	Peptide	Opioid	κ	Homo sapiens	Dynorphin	-	Gi1/β1/γ2	3.3	2023-05-24	doi.org/10.1093/procel/pwac033
	7Y1F (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	Dynorphin	-		3.3	2023-05-24	doi.org/10.1093/procel/pwac033
	9MQK	A	Peptide	Opioid	κ	Homo sapiens	Isoquinuclidine	-	-	3.18	2025-02-12	doi.org/10.1101/2025.01.09.632033
	9MQL	A	Peptide	Opioid	κ	Homo sapiens	Isoquinuclidine	-	-	2.96	2025-02-12	doi.org/10.1101/2025.01.09.632033
	8VVE	A	Peptide	Opioid	κ	Homo sapiens	norBNI	-	Gi1/β1/γ2	3.3	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	8VVE (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	norBNI	-		3.3	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	8VVF	A	Peptide	Opioid	κ	Homo sapiens	JDTic	-	Gi1/β1/γ2	3	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	8VVF (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	JDTic	-		3	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	8VVG	A	Peptide	Opioid	κ	Homo sapiens	GB18	-	Gi1/β1/γ2	3.3	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	8VVG (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	GB18	-		3.3	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	9D61	A	Peptide	Opioid	κ	Homo sapiens	JDTic	-	Gi1/β1/γ2	3.58	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	9D61 (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	JDTic	-		3.58	2025-01-15	doi.org/10.1038/s41589-024-01812-0

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Download 8VVE_nogp.zip

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