psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D138	17.06	Yes	No	0	0	6
2	L:L:?1	R:R:Y139	7.69	Yes	Yes	0	0	5
3	L:L:?1	R:R:M142	7.72	Yes	No	2	0	7
4	L:L:?1	R:R:S211	5.74	Yes	No	0	0	4
5	L:L:?1	R:R:W287	2.49	Yes	Yes	2	0	8
6	L:L:?1	R:R:I290	3.12	Yes	No	0	0	6
7	L:L:?1	R:R:H291	5.62	Yes	Yes	2	0	8
8	L:L:?1	R:R:I294	7.8	Yes	No	2	0	5
9	L:L:?1	R:R:E297	5.79	Yes	Yes	2	0	5
10	L:L:?1	R:R:H304	15.45	Yes	No	2	0	1
11	L:L:?1	R:R:Y312	3.84	Yes	Yes	0	0	4
12	L:L:?1	R:R:Y320	3.84	Yes	Yes	0	0	6
13	R:R:I58	R:R:P59	3.39	No	No	0	4	4
14	R:R:I58	R:R:S310	3.1	No	No	0	4	2
15	R:R:I61	R:R:I62	2.94	No	No	0	5	5
16	R:R:F314	R:R:I61	2.51	No	No	0	5	5
17	R:R:I62	R:R:Y119	25.39	No	No	8	5	4
18	R:R:I62	R:R:Y313	3.63	No	Yes	8	5	4
19	R:R:V65	R:R:V69	3.21	No	Yes	0	5	7
20	R:R:P113	R:R:Y66	2.78	No	No	0	8	6
21	R:R:S116	R:R:Y66	5.09	No	No	0	6	6
22	R:R:M112	R:R:V69	6.09	Yes	Yes	0	7	7
23	R:R:T321	R:R:V69	3.17	No	Yes	0	5	7
24	R:R:S324	R:R:V69	4.85	No	Yes	0	7	7
25	R:R:F70	R:R:L74	8.53	Yes	No	1	7	6
26	R:R:F70	R:R:T109	2.59	Yes	Yes	1	7	6
27	R:R:F70	R:R:M112	3.73	Yes	Yes	1	7	7
28	R:R:F70	R:R:P113	10.11	Yes	No	1	7	8
29	R:R:S324	R:R:V72	4.85	No	No	0	7	5
30	R:R:G73	R:R:T109	3.64	No	Yes	0	8	6
31	R:R:G73	R:R:S324	3.71	No	No	0	8	7
32	R:R:L74	R:R:T109	4.42	No	Yes	1	6	6
33	R:R:L79	R:R:V75	2.98	No	No	0	6	4
34	R:R:D105	R:R:N77	6.73	No	Yes	1	9	9
35	R:R:A106	R:R:N77	6.25	No	Yes	0	8	9
36	R:R:N77	R:R:T109	2.92	Yes	Yes	1	9	6
37	R:R:N77	R:R:P327	9.77	Yes	Yes	1	9	9
38	R:R:P327	R:R:V80	3.53	Yes	No	0	9	9
39	R:R:I84	R:R:M81	2.92	No	Yes	6	7	7
40	R:R:F99	R:R:M81	4.98	Yes	Yes	6	5	7
41	R:R:L103	R:R:M81	2.83	No	Yes	6	6	7
42	R:R:F82	R:R:R86	3.21	No	No	0	4	5
43	R:R:V83	R:R:Y87	22.71	No	Yes	0	8	5
44	R:R:I84	R:R:T88	3.04	No	Yes	0	7	6
45	R:R:F99	R:R:I84	2.51	Yes	No	6	5	7
46	R:R:I85	R:R:R86	6.26	No	No	0	3	5
47	R:R:T88	R:R:Y87	4.99	Yes	Yes	0	6	5
48	R:R:F337	R:R:Y87	11.35	Yes	Yes	0	8	5
49	R:R:C340	R:R:Y87	8.06	No	Yes	0	6	5
50	R:R:F341	R:R:Y87	5.16	No	Yes	0	6	5
51	R:R:K89	R:R:T88	3	No	Yes	0	5	6
52	R:R:N95	R:R:T88	2.92	No	Yes	0	7	6
53	R:R:K89	R:R:K91	12.93	No	No	0	5	7
54	R:R:I96	R:R:M90	4.37	Yes	No	0	5	7
55	R:R:F99	R:R:M90	6.22	Yes	No	0	5	7
56	R:R:T92	R:R:T94	3.14	No	No	0	7	8
57	R:R:N95	R:R:T92	5.85	No	No	0	7	7
58	R:R:F337	R:R:N95	2.42	Yes	No	0	8	7
59	R:R:I96	R:R:Y97	6.04	Yes	Yes	4	5	7
60	R:R:I96	R:R:N179	2.83	Yes	Yes	4	5	7
61	R:R:M152	R:R:Y97	3.59	No	Yes	0	8	7
62	R:R:A175	R:R:Y97	2.67	No	Yes	0	7	7
63	R:R:N179	R:R:Y97	4.65	Yes	Yes	4	7	7
64	R:R:I98	R:R:Y330	4.84	No	Yes	0	8	9
65	R:R:F337	R:R:I98	2.51	Yes	No	0	8	8
66	R:R:F99	R:R:L103	8.53	Yes	No	6	5	6
67	R:R:N100	R:R:N179	14.98	No	Yes	4	9	7
68	R:R:N100	R:R:W183	11.3	No	Yes	4	9	9
69	R:R:L101	R:R:T148	2.95	Yes	No	0	9	7
70	R:R:L101	R:R:L149	5.54	Yes	No	0	9	8
71	R:R:L101	R:R:N326	5.49	Yes	Yes	0	9	9
72	R:R:L101	R:R:Y330	3.52	Yes	Yes	0	9	9
73	R:R:A104	R:R:N141	3.13	No	No	0	8	8
74	R:R:D105	R:R:N326	12.12	No	Yes	1	9	9
75	R:R:D105	R:R:P327	6.44	No	Yes	1	9	9
76	R:R:L107	R:R:N141	2.75	No	No	0	6	8
77	R:R:T111	R:R:V108	3.17	No	Yes	0	7	7
78	R:R:N141	R:R:V108	5.91	No	Yes	0	8	7
79	R:R:S323	R:R:V108	6.46	No	Yes	0	8	7
80	R:R:M112	R:R:P113	3.35	Yes	No	1	7	8
81	R:R:M112	R:R:Y320	19.16	Yes	Yes	0	7	6
82	R:R:Q115	R:R:Y312	5.64	No	Yes	0	7	4
83	R:R:Q115	R:R:Y320	10.15	No	Yes	0	7	6
84	R:R:F126	R:R:T117	7.78	Yes	No	0	7	4
85	R:R:F126	R:R:V118	2.62	Yes	No	0	7	5
86	R:R:L120	R:R:Y119	15.24	No	No	0	4	4
87	R:R:Y119	R:R:Y313	19.86	No	Yes	8	4	4
88	R:R:S123	R:R:V207	4.85	No	No	10	4	3
89	R:R:E209	R:R:S123	4.31	No	No	10	3	4
90	R:R:F126	R:R:W124	4.01	Yes	Yes	0	7	8
91	R:R:G127	R:R:W124	2.81	No	Yes	0	7	8
92	R:R:T199	R:R:W124	4.85	Yes	Yes	7	4	8
93	R:R:I208	R:R:W124	9.4	No	Yes	7	4	8
94	R:R:C210	R:R:W124	13.06	No	Yes	7	9	8
95	R:R:F126	R:R:L130	4.87	Yes	No	0	7	5
96	R:R:D128	R:R:V129	4.38	No	No	0	2	1
97	R:R:D128	R:R:T199	2.89	No	Yes	0	2	4
98	R:R:C131	R:R:C210	7.28	No	No	0	9	9
99	R:R:G198	R:R:K132	6.97	No	No	0	4	6
100	R:R:I133	R:R:I137	2.94	No	No	0	5	5
101	R:R:I135	R:R:Y139	3.63	No	Yes	0	4	5
102	R:R:I194	R:R:S136	3.1	Yes	No	0	4	5
103	R:R:F143	R:R:Y139	5.16	Yes	Yes	0	6	5
104	R:R:A193	R:R:Y139	2.67	No	Yes	0	5	5
105	R:R:W183	R:R:Y140	7.72	Yes	No	0	9	5
106	R:R:S186	R:R:Y140	2.54	No	No	0	8	5
107	R:R:S187	R:R:Y140	2.54	No	No	0	4	5
108	R:R:F143	R:R:M142	6.22	Yes	No	0	6	7
109	R:R:M142	R:R:W287	3.49	No	Yes	2	7	8
110	R:R:F143	R:R:S186	2.64	Yes	No	0	6	8
111	R:R:F143	R:R:V189	6.55	Yes	No	0	6	5
112	R:R:F143	R:R:V230	2.62	Yes	No	0	6	5
113	R:R:T144	R:R:W183	16.98	No	Yes	0	7	9
114	R:R:S186	R:R:T144	4.8	No	No	0	8	7
115	R:R:I146	R:R:P238	3.39	No	No	0	7	9
116	R:R:F147	R:R:T150	2.59	No	No	0	6	7
117	R:R:F147	R:R:I182	2.51	No	No	0	6	7
118	R:R:T148	R:R:W183	2.43	No	Yes	0	7	9
119	R:R:L149	R:R:M152	2.83	No	No	0	8	8
120	R:R:P238	R:R:T150	3.5	No	No	0	9	7
121	R:R:I178	R:R:M151	4.37	No	No	0	6	6
122	R:R:I182	R:R:M151	5.83	No	No	0	7	6
123	R:R:M152	R:R:Y330	3.59	No	Yes	0	8	9
124	R:R:I242	R:R:S153	9.29	No	No	5	8	9
125	R:R:C245	R:R:S153	3.44	Yes	No	0	7	9
126	R:R:S153	R:R:Y246	15.26	No	Yes	5	9	8
127	R:R:D155	R:R:R170	16.68	No	No	0	8	6
128	R:R:R156	R:R:Y246	3.09	No	Yes	5	9	8
129	R:R:M249	R:R:R156	7.44	No	No	5	8	9
130	R:R:C161	R:R:Y157	9.41	No	Yes	0	7	7
131	R:R:H162	R:R:Y157	8.71	No	Yes	0	6	7
132	R:R:C245	R:R:Y157	6.72	Yes	Yes	0	7	7
133	R:R:L248	R:R:Y157	3.52	No	Yes	0	4	7
134	R:R:H162	R:R:I158	3.98	No	No	0	6	5
135	R:R:F169	R:R:I158	5.02	No	No	0	4	5
136	R:R:A159	R:R:R170	4.15	No	No	0	8	6
137	R:R:M249	R:R:V160	7.61	No	No	0	8	8
138	R:R:L253	R:R:V160	2.98	Yes	No	0	8	8
139	R:R:C161	R:R:R252	5.57	No	No	0	7	5
140	R:R:H162	R:R:K165	2.62	No	No	0	6	4
141	R:R:P163	R:R:V164	3.53	No	No	0	8	5
142	R:R:K165	R:R:V164	3.04	No	No	0	4	5
143	R:R:A166	R:R:R170	2.77	No	No	0	5	6
144	R:R:F169	R:R:K174	3.72	No	No	0	4	5
145	R:R:I178	R:R:K174	2.91	No	No	0	6	5
146	R:R:N179	R:R:W183	9.04	Yes	Yes	4	7	9
147	R:R:I182	R:R:W183	2.35	No	Yes	0	7	9
148	R:R:S188	R:R:V189	3.23	No	No	0	4	5
149	R:R:S192	R:R:V189	3.23	No	No	0	7	5
150	R:R:I191	R:R:I194	2.94	No	Yes	0	4	4
151	R:R:F214	R:R:L196	9.74	No	No	0	6	4
152	R:R:I208	R:R:T199	3.04	No	Yes	7	4	4
153	R:R:C210	R:R:T199	3.38	No	Yes	7	9	4
154	R:R:K200	R:R:Q213	4.07	No	Yes	0	2	4
155	R:R:I208	R:R:V201	4.61	No	No	0	4	2
156	R:R:D204	R:R:R202	3.57	No	No	0	2	2
157	R:R:E209	R:R:R202	23.26	No	No	0	3	2
158	R:R:D204	R:R:V205	5.84	No	No	0	2	1
159	R:R:V205	R:R:V207	6.41	No	No	0	1	3
160	R:R:E209	R:R:V207	5.7	No	No	10	3	3
161	R:R:L212	R:R:S211	6.01	No	No	0	4	4
162	R:R:F214	R:R:L212	6.09	No	No	0	6	4
163	R:R:F214	R:R:M226	2.49	No	No	0	6	5
164	R:R:D217	R:R:P215	6.44	No	No	3	1	5
165	R:R:D218	R:R:P215	3.22	No	No	3	4	5
166	R:R:D216	R:R:Y219	3.45	No	No	0	2	1
167	R:R:D217	R:R:D218	13.31	No	No	3	1	4
168	R:R:D218	R:R:W222	7.82	No	No	0	4	7
169	R:R:I294	R:R:K227	7.27	No	No	0	5	4
170	R:R:A298	R:R:K227	4.82	No	No	0	4	4
171	R:R:C229	R:R:F233	2.79	No	No	0	3	4
172	R:R:F231	R:R:H291	6.79	No	Yes	0	5	8
173	R:R:F231	R:R:L295	8.53	No	No	0	5	5
174	R:R:F233	R:R:I232	5.02	No	No	0	4	5
175	R:R:I232	R:R:V236	6.14	No	No	0	5	4
176	R:R:F235	R:R:V239	6.55	No	No	0	8	6
177	R:R:F235	R:R:T288	6.49	No	No	0	8	5
178	R:R:F235	R:R:H291	5.66	No	Yes	0	8	8
179	R:R:I237	R:R:P238	3.39	No	No	0	5	9
180	R:R:F283	R:R:V239	2.62	No	No	0	9	6
181	R:R:I242	R:R:Y246	7.25	No	Yes	5	8	8
182	R:R:M249	R:R:Y246	3.59	No	Yes	5	8	8
183	R:R:V276	R:R:Y246	7.57	No	Yes	0	8	8
184	R:R:V280	R:R:Y246	2.52	No	Yes	0	8	8
185	R:R:I250	R:R:T273	6.08	No	No	0	5	6
186	R:R:L251	R:R:R252	7.29	No	No	0	4	5
187	R:R:R252	R:R:S255	7.91	No	No	0	5	4
188	R:R:L253	R:R:L269	5.54	Yes	Yes	11	8	6
189	R:R:K254	R:R:L269	5.64	No	Yes	0	4	6
190	R:R:L258	R:R:L259	4.15	No	No	0	5	3
191	R:R:K265	R:R:L258	2.82	No	No	0	4	5
192	R:R:D266	R:R:G261	6.71	No	No	0	3	3
193	R:R:K265	R:R:S262	10.71	No	No	0	4	1
194	R:R:E264	R:R:R267	6.98	No	No	0	3	4
195	R:R:R267	R:R:R270	5.33	No	No	0	4	5
196	R:R:I272	R:R:L269	2.85	No	Yes	0	7	6
197	R:R:L275	R:R:L333	2.77	No	No	0	8	7
198	R:R:V279	R:R:Y330	5.05	No	Yes	0	8	9
199	R:R:F283	R:R:W287	8.02	No	Yes	0	9	8
200	R:R:T288	R:R:V284	3.17	No	No	0	5	6
201	R:R:C286	R:R:N322	11.02	No	Yes	0	8	9
202	R:R:H291	R:R:W287	3.17	Yes	Yes	2	8	8
203	R:R:N322	R:R:W287	5.65	Yes	Yes	0	9	8
204	R:R:P289	R:R:T288	5.25	No	No	0	9	5
205	R:R:C315	R:R:I290	4.91	No	No	0	7	6
206	R:R:E297	R:R:F293	11.66	Yes	No	0	5	5
207	R:R:E297	R:R:I294	4.1	Yes	No	2	5	5
208	R:R:L295	R:R:L299	5.54	No	No	0	5	4
209	R:R:T302	R:R:V296	4.76	No	No	0	1	4
210	R:R:E297	R:R:T302	2.82	Yes	No	0	5	1
211	R:R:E297	R:R:H304	4.92	Yes	No	2	5	1
212	R:R:A308	R:R:H304	4.39	No	No	0	3	1
213	R:R:F314	R:R:S310	2.64	No	No	0	5	2
214	R:R:Y312	R:R:Y313	6.95	Yes	Yes	0	4	4
215	R:R:I316	R:R:Y312	8.46	No	Yes	0	5	4
216	R:R:I316	R:R:Y320	4.84	No	Yes	0	5	6
217	R:R:N322	R:R:N326	2.72	Yes	Yes	0	9	9
218	R:R:N326	R:R:P327	4.89	Yes	Yes	1	9	9
219	R:R:L329	R:R:Y330	4.69	No	Yes	0	8	9
220	R:R:L329	R:R:L333	4.15	No	No	0	8	7
221	R:R:F332	R:R:L333	2.44	No	No	0	6	7
222	R:R:F332	R:R:K338	2.48	No	No	0	6	8
223	R:R:D334	R:R:N336	13.46	No	No	9	8	6
224	R:R:D334	R:R:F337	9.55	No	Yes	9	8	8
225	R:R:F337	R:R:N336	12.08	Yes	No	9	8	6
226	R:R:R267	R:R:R271	2.13	No	No	0	4	7
227	R:R:G197	R:R:G198	2.11	No	No	3	4	4
228	R:R:A193	R:R:G190	1.95	No	No	0	5	6
229	R:R:G190	R:R:S136	1.86	No	No	0	6	5
230	R:R:G300	R:R:S301	1.86	No	No	0	2	2
231	R:R:G76	R:R:V75	1.84	No	No	0	7	4
232	R:R:A175	R:R:A93	1.79	No	No	0	7	6
233	R:R:G76	R:R:I328	1.76	No	No	0	7	7
234	R:R:P172	R:R:T171	1.75	No	No	0	2	7
235	R:R:A104	R:R:S145	1.71	No	No	0	8	9
236	R:R:C245	R:R:V154	1.71	Yes	No	0	7	6
237	R:R:C286	R:R:V285	1.71	No	No	0	8	6
238	R:R:G300	R:R:L299	1.71	No	No	0	2	4
239	R:R:A307	R:R:S305	1.71	No	No	0	4	3
240	R:R:A308	R:R:S311	1.71	No	No	0	3	4
241	R:R:G319	R:R:L318	1.71	No	No	0	7	8
242	R:R:A102	R:R:V80	1.7	No	No	0	8	9
243	R:R:A331	R:R:V80	1.7	No	No	0	7	9
244	R:R:G319	R:R:N322	1.7	No	Yes	0	7	9
245	R:R:C131	R:R:I135	1.64	No	No	0	9	4
246	R:R:G197	R:R:Q213	1.64	No	Yes	3	4	4
247	R:R:G198	R:R:Q213	1.64	No	Yes	3	4	4
248	R:R:C245	R:R:I241	1.64	Yes	No	0	7	6
249	L:L:?1	R:R:V108	1.63	Yes	Yes	0	0	7
250	R:R:S301	R:R:S303	1.63	No	No	0	2	1
251	R:R:A64	R:R:I61	1.62	No	No	0	5	5
252	R:R:A234	R:R:I146	1.62	No	No	0	6	7
253	R:R:S255	R:R:V256	1.62	No	No	0	4	6
254	R:R:V68	R:R:V72	1.6	No	No	0	5	5
255	R:R:V71	R:R:V75	1.6	No	No	0	5	4
256	R:R:V278	R:R:V282	1.6	No	No	0	5	7
257	R:R:P215	R:R:Q213	1.58	No	Yes	3	5	4
258	R:R:I133	R:R:V129	1.54	No	No	0	5	1
259	R:R:I194	R:R:V195	1.54	Yes	No	0	4	4
260	R:R:I243	R:R:V239	1.54	No	No	0	5	6
261	R:R:I243	R:R:V280	1.54	No	No	0	5	8
262	R:R:I292	R:R:V296	1.54	No	No	0	5	4
263	R:R:L79	R:R:S78	1.5	No	No	0	6	4
264	R:R:K174	R:R:T171	1.5	No	No	0	5	7
265	R:R:L184	R:R:S187	1.5	No	No	0	4	4
266	R:R:L185	R:R:S188	1.5	No	No	0	4	4
267	R:R:L224	R:R:S220	1.5	No	No	0	3	2
268	R:R:L240	R:R:V244	1.49	No	No	0	3	4
269	R:R:L329	R:R:V282	1.49	No	No	0	8	7
270	R:R:I177	R:R:I178	1.47	No	No	0	3	6
271	R:R:L325	R:R:T321	1.47	No	No	0	6	5
272	R:R:D155	R:R:T94	1.45	No	No	0	8	8
273	R:R:I96	R:R:K176	1.45	Yes	No	0	5	4
274	R:R:I194	R:R:K132	1.45	Yes	No	0	4	6
275	R:R:F126	R:R:P125	1.44	Yes	No	0	7	1
276	R:R:I180	R:R:L184	1.43	No	No	0	4	4
277	R:R:I241	R:R:L240	1.43	No	No	0	6	3
278	R:R:I250	R:R:L253	1.43	No	Yes	0	5	8
279	R:R:L224	R:R:L299	1.38	No	No	0	3	4
280	R:R:L253	R:R:L259	1.38	Yes	No	11	8	3
281	R:R:D266	R:R:K254	1.38	No	No	0	3	4
282	R:R:L259	R:R:L269	1.38	No	Yes	11	3	6
283	R:R:D168	R:R:L167	1.36	No	No	0	4	5
284	R:R:D223	R:R:L212	1.36	No	No	0	4	4
285	R:R:E335	R:R:K338	1.35	No	No	0	4	8
286	R:R:F114	R:R:V134	1.31	No	No	0	5	6
287	R:R:F231	R:R:V236	1.31	No	No	0	5	4
288	R:R:S67	R:R:Y66	1.27	No	No	0	4	6
289	R:R:F82	R:R:M81	1.24	No	Yes	0	4	7
290	R:R:S220	R:R:W221	1.24	No	No	0	2	1
291	R:R:F114	R:R:L130	1.22	No	No	0	5	5
292	R:R:N122	R:R:Y313	1.16	No	Yes	0	5	4
293	R:R:E264	R:R:R263	1.16	No	No	0	3	3
294	R:R:R271	R:R:R274	1.07	No	No	0	7	6
295	R:R:F225	R:R:W222	1	No	No	0	4	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	6.75308	13	2	0
2	R:R:V69	4.33	4	0	7
3	R:R:F70	6.24	4	1	7
4	R:R:N77	6.4175	4	1	9
5	R:R:M81	2.9925	4	6	7
6	R:R:Y87	10.454	5	0	5
7	R:R:T88	3.4875	4	0	6
8	R:R:I96	3.6725	4	4	5
9	R:R:Y97	4.2375	4	4	7
10	R:R:F99	5.56	4	6	5
11	R:R:L101	4.375	4	0	9
12	R:R:V108	4.2925	4	0	7
13	R:R:T109	3.3925	4	1	6
14	R:R:M112	8.0825	4	1	7
15	R:R:W124	6.826	5	7	8
16	R:R:F126	4.144	5	0	7
17	R:R:Y139	4.7875	4	0	5
18	R:R:F143	4.638	5	0	6
19	R:R:Y157	7.09	4	0	7
20	R:R:N179	7.875	4	4	7
21	R:R:W183	8.30333	6	4	9
22	R:R:I194	2.2575	4	0	4
23	R:R:T199	3.54	4	7	4
24	R:R:Q213	2.2325	4	3	4
25	R:R:C245	3.3775	4	0	7
26	R:R:Y246	6.54667	6	5	8
27	R:R:L253	2.8325	4	11	8
28	R:R:L269	3.8525	4	11	6
29	R:R:W287	4.564	5	2	8
30	R:R:H291	5.31	4	2	8
31	R:R:E297	5.858	5	2	5
32	R:R:Y312	6.2225	4	0	4
33	R:R:Y313	7.9	4	8	4
34	R:R:Y320	9.4975	4	0	6
35	R:R:N322	5.2725	4	0	9
36	R:R:N326	6.305	4	1	9
37	R:R:P327	6.1575	4	1	9
38	R:R:Y330	4.338	5	0	9
39	R:R:F337	7.582	5	9	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y312	34.2686	3.84	Yes	Yes	0	0	4
2	R:R:Y312	R:R:Y313	30.4105	6.95	Yes	Yes	0	4	4
3	R:R:I62	R:R:Y313	19.622	3.63	No	Yes	8	5	4
4	R:R:I61	R:R:I62	17.1278	2.94	No	No	0	5	5
5	R:R:F314	R:R:I61	11.464	2.51	No	No	0	5	5
6	L:L:?1	R:R:Y320	38.3866	3.84	Yes	Yes	0	0	6
7	R:R:M112	R:R:Y320	34.8922	19.16	Yes	Yes	0	7	6
8	R:R:M112	R:R:V69	19.1413	6.09	Yes	Yes	0	7	7
9	R:R:P113	R:R:Y66	10.847	2.78	No	No	0	8	6
10	R:R:F70	R:R:M112	10.3988	3.73	Yes	Yes	1	7	7
11	R:R:F70	R:R:T109	14.0881	2.59	Yes	Yes	1	7	6
12	R:R:G73	R:R:T109	10.1195	3.64	No	Yes	0	8	6
13	L:L:?1	R:R:W287	56.6771	2.49	Yes	Yes	2	0	8
14	R:R:N322	R:R:W287	64.6207	5.65	Yes	Yes	0	9	8
15	R:R:N322	R:R:N326	63.2892	2.72	Yes	Yes	0	9	9
16	R:R:D105	R:R:N326	15.478	12.12	No	Yes	1	9	9
17	R:R:D105	R:R:N77	13.9582	6.73	No	Yes	1	9	9
18	R:R:N326	R:R:P327	20.5248	4.89	Yes	Yes	1	9	9
19	R:R:N77	R:R:P327	14.4453	9.77	Yes	Yes	1	9	9
20	R:R:N77	R:R:T109	23.3697	2.92	Yes	Yes	1	9	6
21	L:L:?1	R:R:Y139	84.5674	7.69	Yes	Yes	0	0	5
22	R:R:F143	R:R:Y139	56.2873	5.16	Yes	Yes	0	6	5
23	R:R:F143	R:R:S186	100	2.64	Yes	No	0	6	8
24	R:R:S186	R:R:Y140	52.1239	2.54	No	No	0	8	5
25	R:R:W183	R:R:Y140	48.3048	7.72	Yes	No	0	9	5
26	R:R:N179	R:R:W183	49.6298	9.04	Yes	Yes	4	7	9
27	R:R:I96	R:R:N179	38.8932	2.83	Yes	Yes	4	5	7
28	R:R:I96	R:R:M90	39.5687	4.37	Yes	No	0	5	7
29	R:R:F99	R:R:M90	34.8142	6.22	Yes	No	0	5	7
30	L:L:?1	R:R:M142	34.0933	7.72	Yes	No	2	0	7
31	R:R:F143	R:R:M142	50.0779	6.22	Yes	No	0	6	7
32	R:R:S186	R:R:T144	47.311	4.8	No	No	0	8	7
33	R:R:T144	R:R:W183	46.3562	16.98	No	Yes	0	7	9
34	R:R:L101	R:R:N326	78.6243	5.49	Yes	Yes	0	9	9
35	R:R:L101	R:R:Y330	61.8537	3.52	Yes	Yes	0	9	9
36	R:R:I98	R:R:Y330	40.0429	4.84	No	Yes	0	8	9
37	R:R:F337	R:R:I98	38.5685	2.51	Yes	No	0	8	8
38	R:R:F337	R:R:Y87	14.7961	11.35	Yes	Yes	0	8	5
39	R:R:I84	R:R:T88	10.8405	3.04	No	Yes	0	7	6
40	R:R:F337	R:R:N95	19.8038	2.42	Yes	No	0	8	7
41	R:R:F99	R:R:M81	19.7389	4.98	Yes	Yes	6	5	7
42	R:R:F82	R:R:M81	18.7581	1.24	No	Yes	0	4	7
43	R:R:F82	R:R:R86	12.5162	3.21	No	No	0	4	5
44	R:R:N95	R:R:T92	11.2042	5.85	No	No	0	7	7
45	R:R:L101	R:R:L149	10.5482	5.54	Yes	No	0	9	8
46	R:R:M152	R:R:Y97	17.4721	3.59	No	Yes	0	8	7
47	R:R:M152	R:R:Y330	10.5612	3.59	No	Yes	0	8	9
48	R:R:L101	R:R:T148	22.2525	2.95	Yes	No	0	9	7
49	L:L:?1	R:R:V108	18.0956	1.63	Yes	Yes	0	0	7
50	R:R:N141	R:R:V108	10.4897	5.91	No	Yes	0	8	7
51	R:R:I135	R:R:Y139	43.219	3.63	No	Yes	0	4	5
52	R:R:C131	R:R:I135	41.4523	1.64	No	No	0	9	4
53	R:R:C131	R:R:C210	39.4843	7.28	No	No	0	9	9
54	R:R:C210	R:R:W124	22.7592	13.06	No	Yes	7	9	8
55	R:R:F126	R:R:W124	14.9325	4.01	Yes	Yes	0	7	8
56	R:R:C210	R:R:T199	14.7246	3.38	No	Yes	7	9	4
57	R:R:A193	R:R:Y139	33.5152	2.67	No	Yes	0	5	5
58	R:R:A193	R:R:G190	31.6706	1.95	No	No	0	5	6
59	R:R:G190	R:R:S136	29.6376	1.86	No	No	0	6	5
60	R:R:I194	R:R:S136	27.5916	3.1	Yes	No	0	4	5
61	R:R:I194	R:R:K132	21.3757	1.45	Yes	No	0	4	6
62	R:R:G198	R:R:K132	19.2777	6.97	No	No	0	4	6
63	R:R:F143	R:R:V189	11.3471	6.55	Yes	No	0	6	5
64	R:R:I182	R:R:W183	58.2294	2.35	No	Yes	0	7	9
65	R:R:F147	R:R:I182	22.7137	2.51	No	No	0	6	7
66	R:R:F147	R:R:T150	18.9595	2.59	No	No	0	6	7
67	R:R:P238	R:R:T150	15.1923	3.5	No	No	0	9	7
68	R:R:I182	R:R:M151	35.6781	5.83	No	No	0	7	6
69	R:R:I178	R:R:M151	32.424	4.37	No	No	0	6	6
70	R:R:F283	R:R:W287	49.8051	8.02	No	Yes	0	9	8
71	R:R:F283	R:R:V239	48.1943	2.62	No	No	0	9	6
72	R:R:I243	R:R:V239	75.2208	1.54	No	No	0	5	6
73	R:R:I243	R:R:V280	73.006	1.54	No	No	0	5	8
74	R:R:V280	R:R:Y246	70.7781	2.52	No	Yes	0	8	8
75	L:L:?1	R:R:H291	51.0717	5.62	Yes	Yes	2	0	8
76	R:R:F235	R:R:H291	38.9062	5.66	No	Yes	0	8	8
77	R:R:F235	R:R:V239	29.3193	6.55	No	No	0	8	6
78	R:R:S153	R:R:Y246	32.9761	15.26	No	Yes	5	9	8
79	R:R:C245	R:R:S153	31.5082	3.44	Yes	No	0	7	9
80	R:R:M249	R:R:Y246	35.3988	3.59	No	Yes	5	8	8
81	R:R:C245	R:R:Y157	23.3242	6.72	Yes	Yes	0	7	7
82	R:R:C161	R:R:Y157	11.3276	9.41	No	Yes	0	7	7
83	R:R:H162	R:R:Y157	14.2764	8.71	No	Yes	0	6	7
84	R:R:I178	R:R:K174	25.9418	2.91	No	No	0	6	5
85	R:R:F169	R:R:K174	16.251	3.72	No	No	0	4	5
86	R:R:F169	R:R:I158	13.7958	5.02	No	No	0	4	5
87	R:R:H162	R:R:I158	12.198	3.98	No	No	0	6	5
88	R:R:M249	R:R:V160	32.9956	7.61	No	No	0	8	8
89	R:R:L253	R:R:V160	30.4754	2.98	Yes	No	0	8	8
90	L:L:?1	R:R:S211	14.9844	5.74	Yes	No	0	0	4
91	R:R:L212	R:R:S211	12.6202	6.01	No	No	0	4	4
92	R:R:G198	R:R:Q213	14.9974	1.64	No	Yes	3	4	4
93	R:R:P215	R:R:Q213	10.756	1.58	No	Yes	3	5	4
94	R:R:F231	R:R:H291	37.9449	6.79	No	Yes	0	5	8
95	R:R:F231	R:R:V236	11.9706	1.31	No	No	0	5	4
96	R:R:F231	R:R:L295	23.5191	8.53	No	No	0	5	5
97	R:R:L253	R:R:L269	12.7371	5.54	Yes	Yes	11	8	6
98	R:R:L253	R:R:L259	10.4378	1.38	Yes	No	11	8	3
99	R:R:L329	R:R:Y330	15.1273	4.69	No	Yes	0	8	9
100	L:L:?1	R:R:E297	12.6591	5.79	Yes	Yes	2	0	5
101	R:R:L295	R:R:L299	20.5963	5.54	No	No	0	5	4
102	R:R:T148	R:R:W183	21.9992	2.43	No	Yes	0	7	9
103	R:R:H291	R:R:W287	20.6612	3.17	Yes	Yes	2	8	8
104	R:R:M142	R:R:W287	16.6082	3.49	No	Yes	2	7	8
105	R:R:I96	R:R:Y97	10.2559	6.04	Yes	Yes	4	5	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:D138	17.06	2	Yes	No	0	6	0	1
L:L:?1	R:R:Y139	7.69	2	Yes	Yes	0	5	0	1
L:L:?1	R:R:M142	7.72	2	Yes	No	0	7	0	1
L:L:?1	R:R:S211	5.74	2	Yes	No	0	4	0	1
L:L:?1	R:R:W287	2.49	2	Yes	Yes	0	8	0	1
L:L:?1	R:R:I290	3.12	2	Yes	No	0	6	0	1
L:L:?1	R:R:H291	5.62	2	Yes	Yes	0	8	0	1
L:L:?1	R:R:I294	7.8	2	Yes	No	0	5	0	1
L:L:?1	R:R:E297	5.79	2	Yes	Yes	0	5	0	1
L:L:?1	R:R:H304	15.45	2	Yes	No	0	1	0	1
L:L:?1	R:R:Y312	3.84	2	Yes	Yes	0	4	0	1
L:L:?1	R:R:Y320	3.84	2	Yes	Yes	0	6	0	1
R:R:T111	R:R:V108	3.17	0	No	Yes	7	7	2	1
R:R:N141	R:R:V108	5.91	0	No	Yes	8	7	2	1
R:R:S323	R:R:V108	6.46	0	No	Yes	8	7	2	1
R:R:M112	R:R:Y320	19.16	1	Yes	Yes	7	6	2	1
R:R:Q115	R:R:Y312	5.64	0	No	Yes	7	4	2	1
R:R:Q115	R:R:Y320	10.15	0	No	Yes	7	6	2	1
R:R:I135	R:R:Y139	3.63	0	No	Yes	4	5	2	1
R:R:F143	R:R:Y139	5.16	0	Yes	Yes	6	5	2	1
R:R:A193	R:R:Y139	2.67	0	No	Yes	5	5	2	1
R:R:F143	R:R:M142	6.22	0	Yes	No	6	7	2	1
R:R:M142	R:R:W287	3.49	2	No	Yes	7	8	1	1
R:R:L212	R:R:S211	6.01	0	No	No	4	4	2	1
R:R:I294	R:R:K227	7.27	2	No	No	5	4	1	2
R:R:F231	R:R:H291	6.79	0	No	Yes	5	8	2	1
R:R:F235	R:R:H291	5.66	0	No	Yes	8	8	2	1
R:R:F283	R:R:W287	8.02	0	No	Yes	9	8	2	1
R:R:H291	R:R:W287	3.17	2	Yes	Yes	8	8	1	1
R:R:N322	R:R:W287	5.65	0	Yes	Yes	9	8	2	1
R:R:C315	R:R:I290	4.91	0	No	No	7	6	2	1
R:R:E297	R:R:F293	11.66	2	Yes	No	5	5	1	2
R:R:E297	R:R:I294	4.1	2	Yes	No	5	5	1	1
R:R:E297	R:R:T302	2.82	2	Yes	No	5	1	1	2
R:R:E297	R:R:H304	4.92	2	Yes	No	5	1	1	1
R:R:A308	R:R:H304	4.39	0	No	No	3	1	2	1
R:R:Y312	R:R:Y313	6.95	0	Yes	Yes	4	4	1	2
R:R:I316	R:R:Y312	8.46	0	No	Yes	5	4	2	1
R:R:I316	R:R:Y320	4.84	0	No	Yes	5	6	2	1
L:L:?1	R:R:V108	1.63	2	Yes	Yes	0	7	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8VVE_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.35
Number of Linked Nodes	266
Number of Links	295
Number of Hubs	39
Number of Links mediated by Hubs	145
Number of Communities	11
Number of Nodes involved in Communities	52
Number of Links involved in Communities	63

Path Summary
Number Of Nodes in MetaPath	106
Number Of Links MetaPath	105
Number of Shortest Paths	52227
Length Of Smallest Path	3
Average Path Length	12.3101
Length of Longest Path	26
Minimum Path Strength	1.37
Average Path Strength	4.94697
Maximum Path Strength	20.315
Minimum Path Correlation	0.7
Average Path Correlation	0.924652
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5
Average % Of Corr. Nodes	50.3269
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	45.1683
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• ovulation cycle • rhythmic process • estrous cycle • reproductive process • multicellular organismal reproductive process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled opioid receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • multicellular organismal process • system process • sensory perception • nervous system process • phospholipase C-activating G protein-coupled receptor signaling pathway • trans-synaptic signaling • synaptic signaling • anterograde trans-synaptic signaling • cell-cell signaling • chemical synaptic transmission • behavior • learning • learning or memory • cognition • conditioned place preference • associative learning • biological process involved in interspecies interaction between organisms • response to other organism • defense response • response to external stimulus • response to biotic stimulus • defense response to virus • defense response to other organism • response to stress • response to external biotic stimulus • response to virus • response to acrylamide • response to chemical • response to oxygen-containing compound • response to nitrogen compound • neuropeptide signaling pathway • locomotory behavior • adult behavior • behavioral response to cocaine • response to cocaine • response to alkaloid • response to hormone • response to endogenous stimulus • response to estrogen • immune response • immune system process • homeostatic process • cellular response to glucose stimulus • intracellular glucose homeostasis • cellular response to oxygen-containing compound • response to hexose • cellular response to carbohydrate stimulus • cellular response to chemical stimulus • cellular homeostasis • response to monosaccharide • response to carbohydrate • chemical homeostasis • response to glucose • glucose homeostasis • carbohydrate homeostasis • cellular response to hexose stimulus • intracellular chemical homeostasis • cellular response to monosaccharide stimulus • maternal behavior • parental behavior • reproductive behavior • regulation of localization • negative regulation of luteinizing hormone secretion • regulation of system process • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • regulation of luteinizing hormone secretion • luteinizing hormone secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • regulation of biological quality • regulation of hormone levels • establishment of localization • regulation of secretion • endocrine hormone secretion • negative regulation of gonadotropin secretion • negative regulation of multicellular organismal process • regulation of endocrine process • regulation of hormone secretion • gonadotropin secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • secretion by cell • regulation of secretion by cell • signal release • negative regulation of cellular process • regulation of multicellular organismal process • regulation of signaling • secretion • regulation of transport • regulation of gonadotropin secretion • export from cell • endocrine process • hormone transport • regulation of cell communication • eating behavior • feeding behavior • sensory perception of temperature stimulus • response to lipid • cellular response to lipopolysaccharide • cellular response to molecule of bacterial origin • response to lipopolysaccharide • cellular response to biotic stimulus • response to bacterium • cellular response to lipid • response to molecule of bacterial origin • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-inhibiting opioid receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • monoamine transport • nitrogen compound transport • regulation of catecholamine secretion • positive regulation of biological process • organic hydroxy compound transport • positive regulation of secretion by cell • dopamine transport • positive regulation of amine transport • catecholamine transport • positive regulation of secretion • positive regulation of cellular process • positive regulation of catecholamine secretion • dopamine secretion • positive regulation of dopamine secretion • catecholamine secretion • amine transport • positive regulation of transport • regulation of amine transport • regulation of dopamine secretion • regulation of body fluid levels • secretion by tissue • digestive system process • regulation of digestive system process • body fluid secretion • digestion • saliva secretion • regulation of saliva secretion • response to alcohol • response to ethanol • response to peptide hormone • response to insulin • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • p38MAPK cascade • intracellular signal transduction • positive regulation of response to stimulus • regulation of intracellular signal transduction • intracellular signaling cassette • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • positive regulation of p38MAPK cascade • regulation of response to stimulus • regulation of p38MAPK cascade • MAPK cascade • positive regulation of signaling • regulation of eating behavior • positive regulation of feeding behavior • positive regulation of eating behavior • regulation of behavior • positive regulation of behavior • positive regulation of multicellular organismal process • regulation of feeding behavior • sensory perception of pain • response to nicotine • positive regulation of cation transmembrane transport • regulation of potassium ion transport • monoatomic ion transmembrane transport • potassium ion transmembrane transport • regulation of monoatomic ion transmembrane transport • metal ion transport • monoatomic cation transmembrane transport • positive regulation of monoatomic ion transport • positive regulation of transmembrane transport • monoatomic ion transport • positive regulation of monoatomic ion transmembrane transport • monoatomic cation transport • regulation of metal ion transport • regulation of monoatomic ion transport • inorganic ion transmembrane transport • regulation of potassium ion transmembrane transport • inorganic cation transmembrane transport • transmembrane transport • positive regulation of potassium ion transport • regulation of transmembrane transport • positive regulation of potassium ion transmembrane transport • regulation of monoatomic cation transmembrane transport • potassium ion transport • cell periphery • postsynapse • cellular anatomical structure • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • sarcolemma • T-tubule • somatodendritic compartment • cell body
Gene Ontology	Cellular Component	• cell periphery • postsynapse • cellular anatomical structure • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • sarcolemma • T-tubule • somatodendritic compartment • cell body • perikaryon • neuronal cell body • intracellular anatomical structure • cytoplasm • cytosol • presynapse • presynaptic membrane • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • membrane-bounded organelle • intracellular membrane-bounded organelle • endomembrane system • sarcoplasm • intracellular organelle • organelle • endoplasmic reticulum • sarcoplasmic reticulum • intracellular vesicle • transport vesicle membrane • bounding membrane of organelle • cytoplasmic vesicle • vesicle membrane • synaptic vesicle • synaptic vesicle membrane • vesicle • transport vesicle • exocytic vesicle membrane • cytoplasmic vesicle membrane • secretory vesicle • organelle membrane • exocytic vesicle • mitochondrion • nucleus • membrane-enclosed lumen • intracellular organelle lumen • nucleoplasm • organelle lumen • nuclear lumen • axon • axon terminus • distal axon • neuron projection terminus • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • lysosomal membrane • lysosome • G-protein beta-subunit binding • fibroblast proliferation • D2 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • response to peptide hormone • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • midbody • intracellular membraneless organelle • nucleolus • membraneless organelle • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • Golgi apparatus • ciliary basal body
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	A1A
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	A1A
Name	6-AMINO HEXANOIC ACID
Synonyms
Identifier
Formula	C33 H40 N4 O6
Molecular Weight	588.694
SMILES
PubChem	5327090
Formal Charge	0
Total Atoms	83
Total Chiral Atoms	4
Total Bonds	86
Total Aromatic Bonds	18


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P41145
Sequence	>8VVE_nogp_Chain_R A I P V I I T A V Y S V V F V V G L V G N S L V M F V I I R Y T K M K T A T N I Y I F N L A L A D A L V T T T M P F Q S T V Y L M N S W P F G D V L C K I V I S I D Y Y N M F T S I F T L T M M S V D R Y I A V C H P V K A L D F R T P L K A K I I N I C I W L L S S S V G I S A I V L G G T K V R E D V D V I E C S L Q F P D D D Y S W W D L F M K I C V F I F A F V I P V L I I I V C Y T L M I L R L K S V R L L S G S R E K D R N L R R I T R L V L V V V A V F V V C W T P I H I F I L V E A L G S T S H S T A A L S S Y Y F C I A L G Y T N S S L N P I L Y A F L D E N F K R C F R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9MQL	A	Peptide	Opioid	κ	Homo sapiens	Isoquinuclidine	-	-	2.96	2025-02-12	10.1101/2025.01.09.632033
	9MQK	A	Peptide	Opioid	κ	Homo sapiens	Isoquinuclidine	-	-	3.18	2025-02-12	10.1101/2025.01.09.632033
	9D61	A	Peptide	Opioid	κ	Homo sapiens	JDTic	-	Gi1/β1/γ2	3.58	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	9D61 (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	JDTic	-		3.58	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	8VVG	A	Peptide	Opioid	κ	Homo sapiens	GB18	-	Gi1/β1/γ2	3.3	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	8VVG (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	GB18	-		3.3	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	8VVF	A	Peptide	Opioid	κ	Homo sapiens	JDTic	-	Gi1/β1/γ2	3	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	8VVF (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	JDTic	-		3	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	8VVE	A	Peptide	Opioid	κ	Homo sapiens	norBNI	-	Gi1/β1/γ2	3.3	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	8VVE (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	norBNI	-		3.3	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	8FEG	A	Peptide	Opioid	κ	Homo sapiens	(DNCP)-β-Naloxamine	-	Gi1/β1/γ2	2.54	2023-12-06	10.1038/s41467-023-43718-w
	8FEG (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	(DNCP)-β-Naloxamine	-		2.54	2023-12-06	10.1038/s41467-023-43718-w
	7Y1F	A	Peptide	Opioid	κ	Homo sapiens	Dynorphin	-	Gi1/β1/γ2	3.3	2023-05-24	10.1093/procel/pwac033
	7Y1F (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	Dynorphin	-		3.3	2023-05-24	10.1093/procel/pwac033
	8DZR	A	Peptide	Opioid	κ	Homo sapiens	GR89,696	-	chim(NtGi2-Gt3)/β1/γ2	2.61	2023-05-03	10.1038/s41586-023-06030-7
	8DZR (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	GR89,696	-		2.61	2023-05-03	10.1038/s41586-023-06030-7
	8DZS	A	Peptide	Opioid	κ	Homo sapiens	GR89,696	-	chim(NtGi2-Gz)/β1/γ2	2.65	2023-05-03	10.1038/s41586-023-06030-7
	8DZS (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	GR89,696	-		2.65	2023-05-03	10.1038/s41586-023-06030-7
	8DZP	A	Peptide	Opioid	κ	Homo sapiens	momSalB	-	Gi1/β1/γ2	2.71	2023-05-03	10.1038/s41586-023-06030-7
	8DZP (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	momSalB	-		2.71	2023-05-03	10.1038/s41586-023-06030-7
	8DZQ	A	Peptide	Opioid	κ	Homo sapiens	momSalB	-	Go/β1/γ2	2.82	2023-05-03	10.1038/s41586-023-06030-7
	8DZQ (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	momSalB	-		2.82	2023-05-03	10.1038/s41586-023-06030-7
	7YIT	A	Peptide	Opioid	κ	Homo sapiens	Nalfurafine	-	-	3.3	2023-04-12	10.1038/s41467-023-37041-7
	8F7W	A	Peptide	Opioid	κ	Homo sapiens	Dynorphin	-	Gi1/β1/γ2	3.19	2022-12-14	10.1016/j.cell.2022.12.026
	8F7W (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	Dynorphin	-		3.19	2022-12-14	10.1016/j.cell.2022.12.026
	6VI4	A	Peptide	Opioid	κ	Homo sapiens	JDTic	-	-	3.3	2020-03-18	10.1038/s41467-020-14889-7
	6B73	A	Peptide	Opioid	κ	Homo sapiens	MP1104	-	-	3.1	2018-01-17	10.1016/j.cell.2017.12.011
	4DJH	A	Peptide	Opioid	κ	Homo sapiens	JDTic	-	-	2.9	2012-03-21	10.1038/nature10939
	4DJH (Multimeric)	A	Peptide	Opioid	κ	Homo sapiens	JDTic	-		2.9	2012-03-21	10.1038/nature10939

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Download 8VVE_nogp.zip

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