psnGPCR

Press and hold down the left mouse button and move the mouse to rotate.
Press and hold down the central mouse button and move the mouse to translate.
Use the mouse wheel to zoom in or out.
Click on any atom on your molecule and the corresponding residue label will be placed beneath the viewer.

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Q115	15.67	Yes	No	1	0	7
2	L:L:?1	R:R:L135	8.15	Yes	No	0	0	4
3	L:L:?1	R:R:D138	26.96	Yes	No	0	0	6
4	L:L:?1	R:R:Y139	10.35	Yes	No	0	0	5
5	L:L:?1	R:R:M142	12.48	Yes	No	0	0	7
6	L:L:?1	R:R:V230	7.67	Yes	No	0	0	5
7	L:L:?1	R:R:I290	3.15	Yes	Yes	1	0	6
8	L:L:?1	R:R:H291	10.4	Yes	Yes	1	0	8
9	L:L:?1	R:R:I294	9.45	Yes	No	1	0	5
10	L:L:?1	R:R:I316	5.25	Yes	Yes	1	0	5
11	L:L:?1	R:R:Y320	4.31	Yes	Yes	1	0	6
12	R:R:I58	R:R:P56	5.08	Yes	No	0	4	2
13	R:R:I58	R:R:P59	3.39	Yes	No	0	4	4
14	R:R:I62	R:R:Y313	9.67	No	No	0	5	4
15	R:R:Y313	R:R:Y66	36.74	No	Yes	0	4	6
16	R:R:I316	R:R:Y66	4.84	Yes	Yes	0	5	6
17	R:R:A317	R:R:Y66	5.34	No	Yes	0	5	6
18	R:R:F70	R:R:M112	12.44	No	No	0	7	7
19	R:R:G76	R:R:V75	3.68	No	No	0	7	4
20	R:R:D105	R:R:N77	17.5	Yes	Yes	3	9	9
21	R:R:A106	R:R:N77	6.25	No	Yes	0	8	9
22	R:R:N77	R:R:P327	4.89	Yes	No	3	9	9
23	R:R:A331	R:R:V80	3.39	No	No	0	7	9
24	R:R:F99	R:R:M81	7.46	No	No	0	5	7
25	R:R:F337	R:R:V83	5.24	Yes	No	0	8	8
26	R:R:F337	R:R:I84	7.54	Yes	No	0	8	7
27	R:R:N95	R:R:T92	7.31	No	No	0	7	7
28	R:R:A93	R:R:Y97	2.67	No	Yes	0	6	7
29	R:R:I98	R:R:T94	3.04	No	No	0	8	8
30	R:R:F337	R:R:N95	10.87	Yes	No	0	8	7
31	R:R:I96	R:R:N100	2.83	Yes	No	2	5	9
32	R:R:I96	R:R:N179	4.25	Yes	No	2	5	7
33	R:R:M151	R:R:Y97	5.99	Yes	Yes	2	6	7
34	R:R:M152	R:R:Y97	5.99	No	Yes	0	8	7
35	R:R:D155	R:R:Y97	3.45	No	Yes	0	8	7
36	R:R:A175	R:R:Y97	4	No	Yes	0	7	7
37	R:R:I178	R:R:Y97	4.84	No	Yes	2	6	7
38	R:R:N179	R:R:Y97	10.47	No	Yes	2	7	7
39	R:R:I98	R:R:M152	2.92	No	No	0	8	8
40	R:R:F337	R:R:I98	6.28	Yes	No	0	8	8
41	R:R:N100	R:R:N179	17.71	No	No	2	9	7
42	R:R:N100	R:R:W183	9.04	No	Yes	0	9	9
43	R:R:L101	R:R:L149	2.77	No	No	4	9	8
44	R:R:L101	R:R:Y330	3.52	No	Yes	4	9	9
45	R:R:L103	R:R:L107	2.77	No	No	0	6	6
46	R:R:L103	R:R:W183	3.42	No	Yes	0	6	9
47	R:R:A104	R:R:T144	3.36	No	No	0	8	7
48	R:R:D105	R:R:T109	5.78	Yes	No	3	9	6
49	R:R:D105	R:R:S323	4.42	Yes	No	3	9	8
50	R:R:D105	R:R:P327	11.27	Yes	No	3	9	9
51	R:R:L107	R:R:N141	13.73	No	No	0	6	8
52	R:R:V108	R:R:Y320	2.52	No	Yes	0	7	6
53	R:R:S323	R:R:V108	6.46	No	No	0	8	7
54	R:R:S323	R:R:T109	3.2	No	No	3	8	6
55	R:R:T111	R:R:Y320	6.24	No	Yes	0	7	6
56	R:R:M112	R:R:P113	3.35	No	No	0	7	8
57	R:R:M112	R:R:S116	3.07	No	No	0	7	6
58	R:R:F114	R:R:P113	4.33	Yes	No	0	5	8
59	R:R:F114	R:R:W124	7.02	Yes	Yes	1	5	8
60	R:R:F114	R:R:F126	9.65	Yes	Yes	1	5	7
61	R:R:F114	R:R:L130	13.4	Yes	Yes	1	5	5
62	R:R:F114	R:R:V134	15.73	Yes	No	1	5	6
63	R:R:I316	R:R:Q115	5.49	Yes	No	1	5	7
64	R:R:Q115	R:R:Y320	9.02	No	Yes	1	7	6
65	R:R:F126	R:R:T117	7.78	Yes	No	0	7	4
66	R:R:L309	R:R:Y119	8.21	No	No	0	4	4
67	R:R:Y119	R:R:Y313	34.75	No	No	0	4	4
68	R:R:M121	R:R:S123	6.13	No	No	0	4	4
69	R:R:M121	R:R:P125	8.39	No	No	0	4	1
70	R:R:S123	R:R:V207	3.23	No	No	0	4	3
71	R:R:I208	R:R:S123	4.64	No	No	0	4	4
72	R:R:F126	R:R:W124	7.02	Yes	Yes	1	7	8
73	R:R:L130	R:R:W124	11.39	Yes	Yes	1	5	8
74	R:R:C131	R:R:W124	7.84	No	Yes	1	9	8
75	R:R:I208	R:R:W124	9.4	No	Yes	0	4	8
76	R:R:C210	R:R:W124	20.89	No	Yes	1	9	8
77	R:R:F126	R:R:P125	7.22	Yes	No	0	7	1
78	R:R:F126	R:R:L130	9.74	Yes	Yes	1	7	5
79	R:R:D128	R:R:T199	10.12	No	No	0	2	4
80	R:R:L130	R:R:V134	2.98	Yes	No	1	5	6
81	R:R:C131	R:R:C210	7.28	No	No	1	9	9
82	R:R:I194	R:R:K132	7.27	No	No	0	4	6
83	R:R:I133	R:R:V134	3.07	No	No	0	5	6
84	R:R:I194	R:R:S136	3.1	No	No	0	4	5
85	R:R:I137	R:R:N141	2.83	No	No	0	5	8
86	R:R:V189	R:R:Y139	3.79	No	No	0	5	5
87	R:R:A193	R:R:Y139	2.67	No	No	0	5	5
88	R:R:N141	R:R:Y140	3.49	No	Yes	0	8	5
89	R:R:W183	R:R:Y140	9.65	Yes	Yes	0	9	5
90	R:R:S186	R:R:Y140	10.17	No	Yes	0	8	5
91	R:R:S187	R:R:Y140	7.63	No	Yes	0	4	5
92	R:R:M142	R:R:W287	4.65	No	Yes	0	7	8
93	R:R:F143	R:R:F147	8.57	Yes	No	0	6	6
94	R:R:F143	R:R:V189	13.11	Yes	No	0	6	5
95	R:R:F143	R:R:V230	3.93	Yes	No	0	6	5
96	R:R:A234	R:R:F143	4.16	No	Yes	0	6	6
97	R:R:T144	R:R:W183	10.92	No	Yes	0	7	9
98	R:R:S186	R:R:T144	6.4	No	No	0	8	7
99	R:R:I146	R:R:P238	3.39	No	No	0	7	9
100	R:R:I146	R:R:W287	3.52	No	Yes	0	7	8
101	R:R:F147	R:R:I182	7.54	No	No	0	6	7
102	R:R:L149	R:R:N326	5.49	No	No	4	8	9
103	R:R:L149	R:R:Y330	5.86	No	Yes	4	8	9
104	R:R:M151	R:R:T150	3.01	Yes	No	0	6	7
105	R:R:P238	R:R:T150	3.5	No	No	0	9	7
106	R:R:I241	R:R:T150	6.08	No	No	0	6	7
107	R:R:I178	R:R:M151	4.37	No	Yes	2	6	6
108	R:R:I182	R:R:M151	2.92	No	Yes	0	7	6
109	R:R:M152	R:R:Y330	5.99	No	Yes	0	8	9
110	R:R:I242	R:R:S153	3.1	No	No	5	8	9
111	R:R:C245	R:R:S153	5.16	No	No	0	7	9
112	R:R:S153	R:R:Y246	13.99	No	Yes	5	9	8
113	R:R:D155	R:R:R170	19.06	No	No	0	8	6
114	R:R:R156	R:R:Y246	9.26	No	Yes	0	9	8
115	R:R:R156	R:R:Y330	4.12	No	Yes	0	9	9
116	R:R:I158	R:R:Y157	3.63	No	Yes	0	5	7
117	R:R:C161	R:R:Y157	8.06	No	Yes	0	7	7
118	R:R:H162	R:R:Y157	8.71	No	Yes	0	6	7
119	R:R:C245	R:R:Y157	6.72	No	Yes	0	7	7
120	R:R:L248	R:R:Y157	8.21	No	Yes	0	4	7
121	R:R:A159	R:R:R170	5.53	No	No	0	8	6
122	R:R:M249	R:R:V160	6.09	No	No	0	8	8
123	R:R:R252	R:R:V160	2.62	No	No	0	5	8
124	R:R:L253	R:R:V160	8.94	No	No	0	8	8
125	R:R:C161	R:R:R252	2.79	No	No	0	7	5
126	R:R:H162	R:R:K165	7.86	No	No	0	6	4
127	R:R:D168	R:R:K165	4.15	No	No	0	4	4
128	R:R:A166	R:R:R170	2.77	No	No	0	5	6
129	R:R:F169	R:R:K174	19.85	No	No	0	4	5
130	R:R:P172	R:R:T171	3.5	No	No	0	2	7
131	R:R:I177	R:R:L173	2.85	No	No	0	3	4
132	R:R:I178	R:R:K174	4.36	No	No	0	6	5
133	R:R:L196	R:R:V195	2.98	No	No	0	4	4
134	R:R:L196	R:R:L212	4.15	No	No	0	4	4
135	R:R:I208	R:R:T199	3.04	No	No	0	4	4
136	R:R:K200	R:R:Q213	18.98	No	No	0	2	4
137	R:R:E209	R:R:S211	8.62	No	No	0	3	4
138	R:R:W221	R:R:W222	19.68	No	No	0	1	7
139	R:R:F225	R:R:W221	6.01	No	No	0	4	1
140	R:R:D223	R:R:K227	5.53	No	No	0	4	4
141	R:R:L224	R:R:L299	2.77	No	No	0	3	4
142	R:R:C229	R:R:F225	8.38	No	No	0	3	4
143	R:R:I294	R:R:K227	2.91	No	No	0	5	4
144	R:R:A298	R:R:K227	3.21	No	No	0	4	4
145	R:R:F231	R:R:F235	7.5	Yes	No	1	5	8
146	R:R:F231	R:R:V236	3.93	Yes	No	0	5	4
147	R:R:F231	R:R:H291	9.05	Yes	Yes	1	5	8
148	R:R:F231	R:R:L295	4.87	Yes	No	0	5	5
149	R:R:F233	R:R:I232	5.02	No	No	0	4	5
150	R:R:F235	R:R:T288	7.78	No	No	0	8	5
151	R:R:F235	R:R:H291	4.53	No	Yes	1	8	8
152	R:R:I237	R:R:P238	3.39	No	No	0	5	9
153	R:R:I237	R:R:I241	2.94	No	No	0	5	6
154	R:R:F283	R:R:V239	2.62	No	No	0	9	6
155	R:R:I242	R:R:Y246	3.63	No	Yes	5	8	8
156	R:R:I242	R:R:V280	4.61	No	No	5	8	8
157	R:R:I243	R:R:V280	3.07	No	No	0	5	8
158	R:R:V276	R:R:Y246	7.57	No	Yes	0	8	8
159	R:R:V280	R:R:Y246	2.52	No	Yes	5	8	8
160	R:R:I250	R:R:T273	4.56	No	No	0	5	6
161	R:R:R252	R:R:V256	2.62	No	No	0	5	6
162	R:R:L253	R:R:V256	2.98	No	No	0	8	6
163	R:R:K254	R:R:L269	4.23	No	No	0	4	6
164	R:R:K265	R:R:L259	2.82	Yes	No	0	4	3
165	R:R:L259	R:R:L269	2.77	No	No	0	3	6
166	R:R:K265	R:R:S262	13.77	Yes	No	0	4	1
167	R:R:E264	R:R:K265	2.7	No	Yes	0	3	4
168	R:R:D266	R:R:R270	3.57	No	No	0	3	5
169	R:R:N268	R:R:R267	14.46	No	No	0	5	4
170	R:R:R270	R:R:R274	3.2	No	No	0	5	6
171	R:R:L275	R:R:R271	10.93	No	No	6	8	7
172	R:R:L333	R:R:R271	4.86	No	No	6	7	7
173	R:R:L275	R:R:L333	2.77	No	No	6	8	7
174	R:R:V279	R:R:Y330	6.31	No	Yes	0	8	9
175	R:R:F283	R:R:W287	6.01	No	Yes	0	9	8
176	R:R:C286	R:R:T321	3.38	Yes	No	0	8	5
177	R:R:C286	R:R:N322	3.15	Yes	No	0	8	9
178	R:R:H291	R:R:W287	4.23	Yes	Yes	0	8	8
179	R:R:N322	R:R:W287	16.95	No	Yes	0	9	8
180	R:R:P289	R:R:T288	3.5	No	No	0	9	5
181	R:R:I290	R:R:I294	4.42	Yes	No	1	6	5
182	R:R:C315	R:R:I290	4.91	No	Yes	0	7	6
183	R:R:I290	R:R:I316	2.94	Yes	Yes	1	6	5
184	R:R:E297	R:R:F293	10.49	No	Yes	1	5	5
185	R:R:F293	R:R:S311	7.93	Yes	No	0	5	4
186	R:R:F293	R:R:Y312	10.32	Yes	Yes	1	5	4
187	R:R:C315	R:R:F293	4.19	No	Yes	0	7	5
188	R:R:E297	R:R:Y312	4.49	No	Yes	1	5	4
189	R:R:L309	R:R:Y312	5.86	No	Yes	0	4	4
190	R:R:I316	R:R:Y312	7.25	Yes	Yes	1	5	4
191	R:R:F314	R:R:L318	7.31	No	No	0	5	8
192	R:R:L318	R:R:T321	2.95	No	No	0	8	5
193	R:R:N322	R:R:N326	10.9	No	No	0	9	9
194	R:R:L325	R:R:S324	3	No	No	0	6	7
195	R:R:N326	R:R:Y330	3.49	No	Yes	4	9	9
196	R:R:F332	R:R:I328	10.05	No	No	0	6	7
197	R:R:L329	R:R:L333	2.77	Yes	No	0	8	7
198	R:R:D334	R:R:N336	4.04	No	No	0	8	6
199	R:R:T148	R:R:Y97	2.5	No	Yes	0	7	7
200	R:R:V118	R:R:W124	2.45	No	Yes	0	5	8
201	R:R:F70	R:R:L74	2.44	No	No	0	7	6
202	R:R:F332	R:R:L79	2.44	No	No	0	6	6
203	L:L:?1	R:R:C210	2.34	Yes	No	1	0	9
204	R:R:E264	R:R:R267	2.33	No	No	0	3	4
205	R:R:R271	R:R:R274	2.13	No	No	0	7	6
206	R:R:G197	R:R:G198	2.11	No	No	0	4	4
207	R:R:A193	R:R:G190	1.95	No	No	0	5	6
208	R:R:G73	R:R:S324	1.86	No	No	0	8	7
209	R:R:G73	R:R:V72	1.84	No	No	0	8	5
210	R:R:G73	R:R:T109	1.82	No	No	0	8	6
211	R:R:G76	R:R:L79	1.71	No	No	0	7	6
212	R:R:A104	R:R:S145	1.71	No	No	0	8	9
213	R:R:G127	R:R:L130	1.71	No	Yes	0	7	5
214	R:R:A193	R:R:S136	1.71	No	No	0	5	5
215	R:R:C245	R:R:V154	1.71	No	No	0	7	6
216	R:R:C286	R:R:V282	1.71	Yes	No	0	8	7
217	R:R:C286	R:R:V285	1.71	Yes	No	0	8	6
218	R:R:A102	R:R:V80	1.7	No	No	0	8	9
219	R:R:I96	R:R:P172	1.69	Yes	No	0	5	2
220	R:R:I328	R:R:P327	1.69	No	No	0	7	9
221	R:R:S324	R:R:V69	1.62	No	No	0	7	7
222	R:R:A102	R:R:M81	1.61	No	No	0	8	7
223	R:R:V65	R:R:V69	1.6	No	No	0	5	7
224	R:R:V68	R:R:V72	1.6	No	No	0	5	5
225	R:R:V71	R:R:V75	1.6	No	No	0	5	4
226	R:R:V239	R:R:V284	1.6	No	No	0	6	6
227	R:R:C181	R:R:L185	1.59	No	No	0	4	4
228	R:R:A298	R:R:L224	1.58	No	No	0	4	3
229	R:R:T110	R:R:T111	1.57	No	No	0	4	7
230	R:R:A102	R:R:N77	1.56	No	Yes	0	8	9
231	R:R:I58	R:R:S310	1.55	Yes	No	0	4	2
232	R:R:I61	R:R:V60	1.54	No	No	0	5	5
233	R:R:I133	R:R:V129	1.54	No	No	0	5	1
234	R:R:I191	R:R:V195	1.54	No	No	0	4	4
235	R:R:I194	R:R:V195	1.54	No	No	0	4	4
236	R:R:I232	R:R:V236	1.54	No	No	0	5	4
237	R:R:I272	R:R:V276	1.54	No	No	0	7	8
238	R:R:H162	R:R:P163	1.53	No	No	0	6	8
239	R:R:K165	R:R:V164	1.52	No	No	0	4	5
240	R:R:I292	R:R:T288	1.52	No	No	0	5	5
241	R:R:L240	R:R:V244	1.49	No	No	0	3	4
242	R:R:L248	R:R:V244	1.49	No	No	0	4	4
243	R:R:L259	R:R:V256	1.49	No	No	0	3	6
244	R:R:L277	R:R:V276	1.49	No	No	0	4	8
245	R:R:L329	R:R:V278	1.49	Yes	No	0	8	5
246	R:R:L329	R:R:V279	1.49	Yes	No	0	8	8
247	R:R:L329	R:R:V282	1.49	Yes	No	0	8	7
248	R:R:I58	R:R:I62	1.47	Yes	No	0	4	5
249	R:R:L173	R:R:T171	1.47	No	No	0	4	7
250	R:R:I228	R:R:I232	1.47	No	No	0	5	5
251	R:R:L248	R:R:T247	1.47	No	No	0	4	4
252	R:R:L251	R:R:T247	1.47	No	No	0	4	4
253	R:R:I250	R:R:I272	1.47	No	No	0	5	7
254	R:R:L269	R:R:T273	1.47	No	No	0	6	6
255	R:R:L277	R:R:T273	1.47	No	No	0	4	6
256	R:R:D334	R:R:T94	1.45	No	No	0	8	8
257	R:R:I96	R:R:K176	1.45	Yes	No	0	5	4
258	R:R:L120	R:R:M121	1.41	No	No	0	4	4
259	R:R:L212	R:R:M226	1.41	No	No	0	4	5
260	R:R:K265	R:R:L258	1.41	Yes	No	0	4	5
261	R:R:R263	R:R:S262	1.32	No	No	0	3	1
262	R:R:T63	R:R:Y66	1.25	No	Yes	0	5	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	9.68167	12	1	0
2	R:R:I58	2.8725	4	0	4
3	R:R:Y66	12.0425	4	0	6
4	R:R:N77	7.55	4	3	9
5	R:R:I96	2.555	4	2	5
6	R:R:Y97	4.98875	8	2	7
7	R:R:D105	9.7425	4	3	9
8	R:R:F114	10.026	5	1	5
9	R:R:W124	9.43	7	1	8
10	R:R:F126	8.282	5	1	7
11	R:R:L130	7.844	5	1	5
12	R:R:Y140	7.735	4	0	5
13	R:R:F143	7.4425	4	0	6
14	R:R:M151	4.0725	4	2	6
15	R:R:Y157	7.066	5	0	7
16	R:R:W183	8.2575	4	0	9
17	R:R:F231	6.3375	4	1	5
18	R:R:Y246	7.394	5	5	8
19	R:R:K265	5.175	4	0	4
20	R:R:C286	2.4875	4	0	8
21	R:R:W287	7.072	5	0	8
22	R:R:I290	3.855	4	1	6
23	R:R:H291	7.0525	4	1	8
24	R:R:F293	8.2325	4	1	5
25	R:R:Y312	6.98	4	1	4
26	R:R:I316	5.154	5	1	5
27	R:R:Y320	5.5225	4	1	6
28	R:R:L329	1.81	4	0	8
29	R:R:Y330	4.88167	6	4	9
30	R:R:F337	7.4825	4	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:I316	28.4874	5.25	Yes	Yes	1	0	5
2	R:R:I316	R:R:Y66	19.4332	4.84	Yes	Yes	0	5	6
3	R:R:Y313	R:R:Y66	13.7417	36.74	No	Yes	0	4	6
4	R:R:I62	R:R:Y313	10.082	9.67	No	No	0	5	4
5	L:L:?1	R:R:C210	50.4337	2.34	Yes	No	1	0	9
6	R:R:C210	R:R:W124	47.4038	20.89	No	Yes	1	9	8
7	R:R:F114	R:R:W124	15.4765	7.02	Yes	Yes	1	5	8
8	L:L:?1	R:R:Y320	48.0454	4.31	Yes	Yes	1	0	6
9	R:R:V108	R:R:Y320	46.3344	2.52	No	Yes	0	7	6
10	R:R:S323	R:R:V108	44.6233	6.46	No	No	0	8	7
11	R:R:D105	R:R:S323	27.9765	4.42	Yes	No	3	9	8
12	R:R:D105	R:R:P327	13.4268	11.27	Yes	No	3	9	9
13	R:R:I328	R:R:P327	11.793	1.69	No	No	0	7	9
14	R:R:D105	R:R:N77	13.4268	17.5	Yes	Yes	3	9	9
15	L:L:?1	R:R:M142	51.0516	12.48	Yes	No	0	0	7
16	R:R:M142	R:R:W287	51.4199	4.65	No	Yes	0	7	8
17	R:R:N322	R:R:W287	100	16.95	No	Yes	0	9	8
18	R:R:N322	R:R:N326	83.264	10.9	No	No	0	9	9
19	R:R:N326	R:R:Y330	79.7053	3.49	No	Yes	4	9	9
20	R:R:M152	R:R:Y330	34.2799	5.99	No	Yes	0	8	9
21	R:R:I98	R:R:M152	18.0133	2.92	No	No	0	8	8
22	R:R:F337	R:R:I98	10.1236	6.28	Yes	No	0	8	8
23	L:L:?1	R:R:H291	57.2065	10.4	Yes	Yes	1	0	8
24	R:R:H291	R:R:W287	60.0345	4.23	Yes	Yes	0	8	8
25	L:L:?1	R:R:V230	20.9957	7.67	Yes	No	0	0	5
26	R:R:F143	R:R:V230	20.0154	3.93	Yes	No	0	6	5
27	R:R:F143	R:R:F147	23.2236	8.57	Yes	No	0	6	6
28	R:R:F147	R:R:I182	23.0394	7.54	No	No	0	6	7
29	R:R:I182	R:R:M151	23.0157	2.92	No	Yes	0	7	6
30	R:R:M151	R:R:Y97	26.3961	5.99	Yes	Yes	2	6	7
31	R:R:N179	R:R:Y97	27.323	10.47	No	Yes	2	7	7
32	R:R:N100	R:R:N179	17.8351	17.71	No	No	2	9	7
33	R:R:N100	R:R:W183	16.9617	9.04	No	Yes	0	9	9
34	R:R:S323	R:R:T109	14.918	3.2	No	No	3	8	6
35	R:R:I316	R:R:Y312	11.3415	7.25	Yes	Yes	1	5	4
36	R:R:I208	R:R:W124	12.7139	9.4	No	Yes	0	4	8
37	L:L:?1	R:R:Y139	18.548	10.35	Yes	No	0	0	5
38	R:R:A193	R:R:Y139	18.6371	2.67	No	No	0	5	5
39	R:R:A193	R:R:S136	15.1557	1.71	No	No	0	5	5
40	R:R:I194	R:R:S136	13.2723	3.1	No	No	0	4	5
41	R:R:I146	R:R:W287	12.2861	3.52	No	Yes	0	7	8
42	R:R:I146	R:R:P238	10.8009	3.39	No	No	0	7	9
43	R:R:R156	R:R:Y330	75.2079	4.12	No	Yes	0	9	9
44	R:R:R156	R:R:Y246	73.9544	9.26	No	Yes	0	9	8
45	R:R:S153	R:R:Y246	39.3655	13.99	No	Yes	5	9	8
46	R:R:C245	R:R:S153	38.0466	5.16	No	No	0	7	9
47	R:R:C245	R:R:Y157	34.7077	6.72	No	Yes	0	7	7
48	R:R:C161	R:R:Y157	13.8902	8.06	No	Yes	0	7	7
49	R:R:C161	R:R:R252	12.0901	2.79	No	No	0	7	5
50	R:R:V276	R:R:Y246	29.7231	7.57	No	Yes	0	8	8
51	R:R:L277	R:R:V276	24.7802	1.49	No	No	0	4	8
52	R:R:L277	R:R:T273	23.0097	1.47	No	No	0	4	6
53	R:R:L269	R:R:T273	21.471	1.47	No	No	0	6	6
54	R:R:L259	R:R:L269	18.7262	2.77	No	No	0	3	6
55	L:L:?1	R:R:I294	10.7712	9.45	Yes	No	1	0	5
56	R:R:K265	R:R:L259	13.8011	2.82	Yes	No	0	4	3
57	R:R:C286	R:R:N322	21.4651	3.15	Yes	No	0	8	9
58	R:R:C286	R:R:V282	12.0485	1.71	Yes	No	0	8	7
59	R:R:L329	R:R:V282	11.2167	1.49	Yes	No	0	8	7
60	R:R:L329	R:R:L333	11.3296	2.77	Yes	No	0	8	7
61	R:R:G73	R:R:T109	13.7179	1.82	No	No	0	8	6
62	R:R:M152	R:R:Y97	21.1324	5.99	No	Yes	0	8	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:Q115	15.67	1	Yes	No	0	7	0	1
L:L:?1	R:R:L135	8.15	1	Yes	No	0	4	0	1
L:L:?1	R:R:D138	26.96	1	Yes	No	0	6	0	1
L:L:?1	R:R:Y139	10.35	1	Yes	No	0	5	0	1
L:L:?1	R:R:M142	12.48	1	Yes	No	0	7	0	1
L:L:?1	R:R:V230	7.67	1	Yes	No	0	5	0	1
L:L:?1	R:R:I290	3.15	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:H291	10.4	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:I294	9.45	1	Yes	No	0	5	0	1
L:L:?1	R:R:I316	5.25	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:Y320	4.31	1	Yes	Yes	0	6	0	1
R:R:I316	R:R:Y66	4.84	1	Yes	Yes	5	6	1	2
R:R:V108	R:R:Y320	2.52	0	No	Yes	7	6	2	1
R:R:T111	R:R:Y320	6.24	0	No	Yes	7	6	2	1
R:R:I316	R:R:Q115	5.49	1	Yes	No	5	7	1	1
R:R:Q115	R:R:Y320	9.02	1	No	Yes	7	6	1	1
R:R:C131	R:R:W124	7.84	1	No	Yes	9	8	2	2
R:R:C210	R:R:W124	20.89	1	No	Yes	9	8	1	2
R:R:C131	R:R:C210	7.28	1	No	No	9	9	2	1
R:R:V189	R:R:Y139	3.79	0	No	No	5	5	2	1
R:R:A193	R:R:Y139	2.67	0	No	No	5	5	2	1
R:R:M142	R:R:W287	4.65	0	No	Yes	7	8	1	2
R:R:F143	R:R:V189	13.11	0	Yes	No	6	5	2	2
R:R:F143	R:R:V230	3.93	0	Yes	No	6	5	2	1
R:R:I294	R:R:K227	2.91	1	No	No	5	4	1	2
R:R:F231	R:R:F235	7.5	1	Yes	No	5	8	2	2
R:R:F231	R:R:H291	9.05	1	Yes	Yes	5	8	2	1
R:R:F235	R:R:H291	4.53	1	No	Yes	8	8	2	1
R:R:H291	R:R:W287	4.23	1	Yes	Yes	8	8	1	2
R:R:I290	R:R:I294	4.42	1	Yes	No	6	5	1	1
R:R:C315	R:R:I290	4.91	0	No	Yes	7	6	2	1
R:R:I290	R:R:I316	2.94	1	Yes	Yes	6	5	1	1
R:R:I316	R:R:Y312	7.25	1	Yes	Yes	5	4	1	2
L:L:?1	R:R:C210	2.34	1	Yes	No	0	9	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8DZR_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.52
Number of Linked Nodes	235
Number of Links	262
Number of Hubs	30
Number of Links mediated by Hubs	125
Number of Communities	6
Number of Nodes involved in Communities	41
Number of Links involved in Communities	55

Path Summary
Number Of Nodes in MetaPath	63
Number Of Links MetaPath	62
Number of Shortest Paths	36252
Length Of Smallest Path	3
Average Path Length	12.2852
Length of Longest Path	28
Minimum Path Strength	1.47
Average Path Strength	6.74342
Maximum Path Strength	26.5667
Minimum Path Correlation	0.7
Average Path Correlation	0.918153
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.7619
Average % Of Corr. Nodes	48.2886
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	38.6803
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• G protein-coupled receptor-like
SCOP2	Family Identifier	• G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	U9I
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	U9I
Name	methyl (3R)-4-[(3,4-dichlorophenyl)acetyl]-3-[(pyrrolidin-1-yl)methyl]piperazine-1-carboxylate
Synonyms
Identifier
Formula	C19 H25 Cl2 N3 O3
Molecular Weight	414.326
SMILES
PubChem	6603856
Formal Charge	0
Total Atoms	52
Total Chiral Atoms	1
Total Bonds	54
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P41145
Sequence	>8DZR_nogp_Chain_R P A I P V I I T A V Y S V V F V V G L V G N S L V M F V I I K T A T N I Y I F N L A L A D A L V T T T M P F Q S T V Y L M N S W P F G D V L C K I V L S I D Y Y N M F T S I F T L T M M S V D R Y I A V C H P V K A L D F R T P L K A K I I N I C I W L L S S S V G I S A I V L G G T K V V I E C S L Q W W D L F M K I C V F I F A F V I P V L I I I V C Y T L M I L R L K S V R L L S G S R E K D R N L R R I T R L V L V V V A V F V V C W T P I H I F I L V E A L A A L S S Y Y F C I A L G Y T N S S L N P I L Y A F L D E N F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	4DJH	A	Peptide	Opioid	κ	Homo sapiens	JDTic	-	-	2.9	2012-03-21	doi.org/10.1038/nature10939
	6B73	A	Peptide	Opioid	κ	Homo sapiens	MP1104	-	-	3.1	2018-01-17	doi.org/10.1016/j.cell.2017.12.011
	6VI4	A	Peptide	Opioid	κ	Homo sapiens	JDTic	-	-	3.3	2020-03-18	doi.org/10.1038/s41467-020-14889-7
	8F7W	A	Peptide	Opioid	κ	Homo sapiens	Dynorphin	-	Gi1/β1/γ2	3.19	2022-12-14	doi.org/10.1016/j.cell.2022.12.026
	8F7W (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	Dynorphin	-		3.19	2022-12-14	doi.org/10.1016/j.cell.2022.12.026
	7YIT	A	Peptide	Opioid	κ	Homo sapiens	Nalfurafine	-	-	3.3	2023-04-12	doi.org/10.1038/s41467-023-37041-7
	8DZP	A	Peptide	Opioid	κ	Homo sapiens	momSalB	-	Gi1/β1/γ2	2.71	2023-05-03	doi.org/10.1038/s41586-023-06030-7
	8DZP (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	momSalB	-		2.71	2023-05-03	doi.org/10.1038/s41586-023-06030-7
	8DZQ	A	Peptide	Opioid	κ	Homo sapiens	momSalB	-	Go/β1/γ2	2.82	2023-05-03	doi.org/10.1038/s41586-023-06030-7
	8DZQ (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	momSalB	-		2.82	2023-05-03	doi.org/10.1038/s41586-023-06030-7
	8DZR	A	Peptide	Opioid	κ	Homo sapiens	GR89,696	-	chim(NtGi2-Gt3)/β1/γ2	2.61	2023-05-03	doi.org/10.1038/s41586-023-06030-7
	8DZR (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	GR89,696	-		2.61	2023-05-03	doi.org/10.1038/s41586-023-06030-7
	8DZS	A	Peptide	Opioid	κ	Homo sapiens	GR89,696	-	chim(NtGi2-Gz)/β1/γ2	2.65	2023-05-03	doi.org/10.1038/s41586-023-06030-7
	8DZS (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	GR89,696	-		2.65	2023-05-03	doi.org/10.1038/s41586-023-06030-7
	7Y1F	A	Peptide	Opioid	κ	Homo sapiens	Dynorphin	-	Gi1/β1/γ2	3.3	2023-05-24	doi.org/10.1093/procel/pwac033
	7Y1F (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	Dynorphin	-		3.3	2023-05-24	doi.org/10.1093/procel/pwac033
	9MQK	A	Peptide	Opioid	κ	Homo sapiens	Isoquinuclidine	-	-	3.18	2025-02-12	doi.org/10.1101/2025.01.09.632033
	9MQL	A	Peptide	Opioid	κ	Homo sapiens	Isoquinuclidine	-	-	2.96	2025-02-12	doi.org/10.1101/2025.01.09.632033
	8FEG	A	Peptide	Opioid	κ	Homo sapiens	(DNCP)-β-Naloxamine	-	Gi1/β1/γ2	2.54	2023-12-06	doi.org/10.1038/s41467-023-43718-w
	8FEG (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	(DNCP)-β-Naloxamine	-		2.54	2023-12-06	doi.org/10.1038/s41467-023-43718-w
	8VVE	A	Peptide	Opioid	κ	Homo sapiens	norBNI	-	Gi1/β1/γ2	3.3	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	8VVE (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	norBNI	-		3.3	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	8VVF	A	Peptide	Opioid	κ	Homo sapiens	JDTic	-	Gi1/β1/γ2	3	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	8VVF (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	JDTic	-		3	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	8VVG	A	Peptide	Opioid	κ	Homo sapiens	GB18	-	Gi1/β1/γ2	3.3	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	8VVG (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	GB18	-		3.3	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	9D61	A	Peptide	Opioid	κ	Homo sapiens	JDTic	-	Gi1/β1/γ2	3.58	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	9D61 (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	JDTic	-		3.58	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	9V6O	A	Peptide	Opioid	κ	Homo sapiens	Nalfurafine	-	Gi1/β1/γ2	2.76	2025-11-19	10.1038/s41467-025-64882-1
	9V6O (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	Nalfurafine	-		2.76	2025-11-19	10.1038/s41467-025-64882-1
	9W49	A	Peptide	Opioid	κ	Homo sapiens	U-50488H	-	Gi1/β1/γ2	2.9	2025-11-19	10.1038/s41467-025-64882-1
	9W49 (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	U-50488H	-		2.9	2025-11-19	10.1038/s41467-025-64882-1
	9L60	A	Peptide	Opioid	κ	Homo sapiens	Dynorphin	MPAM-15	Gi1/β1/γ2	2.9	2025-12-31	To be published
	9L60 (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	Dynorphin	MPAM-15		2.9	2025-12-31	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8DZR_nogp.zip

You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.

You can also read or download a guide explaining the meaning of all files and numerical data.