psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Q115	6.91	Yes	No	1	0	7
2	L:L:?1	R:R:V118	2.9	Yes	No	1	0	5
3	L:L:?1	R:R:D138	22.9	Yes	No	1	0	6
4	L:L:?1	R:R:Y139	7.61	Yes	Yes	1	0	5
5	L:L:?1	R:R:M142	9.18	Yes	No	1	0	7
6	L:L:?1	R:R:K227	7.32	Yes	Yes	1	0	4
7	L:L:?1	R:R:I290	2.78	Yes	Yes	1	0	6
8	L:L:?1	R:R:H291	4.17	Yes	Yes	1	0	8
9	L:L:?1	R:R:I294	6.48	Yes	No	1	0	5
10	L:L:?1	R:R:I316	5.56	Yes	Yes	1	0	5
11	L:L:?1	R:R:Y320	13.7	Yes	Yes	1	0	6
12	R:R:I58	R:R:P59	3.39	No	No	0	4	4
13	R:R:P59	R:R:Y119	2.78	No	Yes	0	4	4
14	R:R:M112	R:R:Y66	7.18	Yes	No	1	7	6
15	R:R:S116	R:R:Y66	2.54	No	No	0	6	6
16	R:R:Y320	R:R:Y66	9.93	Yes	No	1	6	6
17	R:R:S324	R:R:V69	3.23	No	No	0	7	7
18	R:R:F70	R:R:L74	8.53	Yes	No	1	7	6
19	R:R:F70	R:R:T109	2.59	Yes	No	1	7	6
20	R:R:F70	R:R:M112	11.2	Yes	Yes	1	7	7
21	R:R:F70	R:R:P113	10.11	Yes	No	0	7	8
22	R:R:L74	R:R:T109	4.42	No	No	1	6	6
23	R:R:G76	R:R:L79	5.13	No	No	0	7	6
24	R:R:A102	R:R:N77	3.13	No	Yes	0	8	9
25	R:R:D105	R:R:N77	2.69	Yes	Yes	3	9	9
26	R:R:A106	R:R:N77	3.13	No	Yes	0	8	9
27	R:R:N77	R:R:P327	6.52	Yes	No	3	9	9
28	R:R:F99	R:R:M81	4.98	No	No	0	5	7
29	R:R:A102	R:R:M81	3.22	No	No	0	8	7
30	R:R:F337	R:R:V83	2.62	Yes	No	0	8	8
31	R:R:F341	R:R:V83	6.55	No	No	0	6	8
32	R:R:I84	R:R:M90	4.37	No	No	0	7	7
33	R:R:I84	R:R:N95	2.83	No	No	0	7	7
34	R:R:F337	R:R:I84	3.77	Yes	No	0	8	7
35	R:R:I85	R:R:R86	6.26	No	No	0	3	5
36	R:R:F337	R:R:T88	6.49	Yes	No	0	8	6
37	R:R:C340	R:R:T88	3.38	No	No	0	6	6
38	R:R:I96	R:R:M90	2.92	Yes	No	0	5	7
39	R:R:F99	R:R:M90	4.98	No	No	0	5	7
40	R:R:K91	R:R:P172	10.04	No	No	0	7	2
41	R:R:T92	R:R:T94	3.14	No	No	0	7	8
42	R:R:N95	R:R:T92	7.31	No	No	0	7	7
43	R:R:I96	R:R:Y97	4.84	Yes	No	0	5	7
44	R:R:I96	R:R:K176	4.36	Yes	No	0	5	4
45	R:R:I96	R:R:N179	7.08	Yes	Yes	0	5	7
46	R:R:I98	R:R:Y330	3.63	No	No	0	8	9
47	R:R:N100	R:R:T148	4.39	No	No	0	9	7
48	R:R:N100	R:R:N179	13.62	No	Yes	2	9	7
49	R:R:N100	R:R:W183	11.3	No	Yes	2	9	9
50	R:R:L101	R:R:T148	7.37	No	No	0	9	7
51	R:R:L101	R:R:L149	4.15	No	No	4	9	8
52	R:R:L103	R:R:L107	4.15	No	No	0	6	6
53	R:R:A104	R:R:N141	3.13	No	No	0	8	8
54	R:R:A104	R:R:T144	3.36	No	Yes	0	8	7
55	R:R:D105	R:R:S323	5.89	Yes	No	0	9	8
56	R:R:D105	R:R:N326	4.04	Yes	No	0	9	9
57	R:R:D105	R:R:P327	3.22	Yes	No	3	9	9
58	R:R:N141	R:R:V108	11.82	No	No	0	8	7
59	R:R:V108	R:R:Y320	3.79	No	Yes	0	7	6
60	R:R:S323	R:R:V108	3.23	No	No	0	8	7
61	R:R:M112	R:R:T109	9.03	Yes	No	1	7	6
62	R:R:F114	R:R:T111	2.59	Yes	Yes	1	5	7
63	R:R:T111	R:R:V134	3.17	Yes	No	1	7	6
64	R:R:I137	R:R:T111	3.04	No	Yes	0	5	7
65	R:R:T111	R:R:Y320	4.99	Yes	Yes	1	7	6
66	R:R:M112	R:R:Y320	10.78	Yes	Yes	1	7	6
67	R:R:F114	R:R:F126	7.5	Yes	Yes	1	5	7
68	R:R:F114	R:R:L130	3.65	Yes	Yes	1	5	5
69	R:R:F114	R:R:V134	2.62	Yes	No	1	5	6
70	R:R:Q115	R:R:V118	4.3	No	No	1	7	5
71	R:R:I316	R:R:Q115	5.49	Yes	No	1	5	7
72	R:R:F126	R:R:T117	2.59	Yes	No	0	7	4
73	R:R:V118	R:R:W124	3.68	No	Yes	1	5	8
74	R:R:Y119	R:R:Y313	9.93	Yes	No	0	4	4
75	R:R:M121	R:R:S123	3.07	No	No	0	4	4
76	R:R:S123	R:R:V207	4.85	No	No	0	4	3
77	R:R:F126	R:R:W124	9.02	Yes	Yes	1	7	8
78	R:R:G127	R:R:W124	2.81	No	Yes	0	7	8
79	R:R:T199	R:R:W124	7.28	Yes	Yes	1	4	8
80	R:R:I208	R:R:W124	18.79	No	Yes	1	4	8
81	R:R:C210	R:R:W124	5.22	No	Yes	1	9	8
82	R:R:F126	R:R:L130	6.09	Yes	Yes	1	7	5
83	R:R:D128	R:R:T199	4.34	No	Yes	0	2	4
84	R:R:I133	R:R:L130	2.85	No	Yes	0	5	5
85	R:R:C131	R:R:C210	7.28	No	No	0	9	9
86	R:R:I194	R:R:K132	4.36	Yes	No	0	4	6
87	R:R:I194	R:R:S136	6.19	Yes	No	0	4	5
88	R:R:D138	R:R:Y139	6.9	No	Yes	1	6	5
89	R:R:M142	R:R:Y139	3.59	No	Yes	1	7	5
90	R:R:A193	R:R:Y139	2.67	No	Yes	0	5	5
91	R:R:T144	R:R:Y140	3.75	Yes	Yes	2	7	5
92	R:R:W183	R:R:Y140	11.58	Yes	Yes	2	9	5
93	R:R:S186	R:R:Y140	5.09	No	Yes	2	8	5
94	R:R:S187	R:R:Y140	6.36	No	Yes	0	4	5
95	R:R:F143	R:R:F147	5.36	No	No	0	6	6
96	R:R:F143	R:R:V189	15.73	No	No	0	6	5
97	R:R:F143	R:R:V230	2.62	No	No	0	6	5
98	R:R:T144	R:R:W183	9.7	Yes	Yes	2	7	9
99	R:R:S186	R:R:T144	3.2	No	Yes	2	8	7
100	R:R:I146	R:R:P238	3.39	No	No	0	7	9
101	R:R:F147	R:R:L185	4.87	No	No	0	6	4
102	R:R:P238	R:R:T150	3.5	No	No	0	9	7
103	R:R:I241	R:R:T150	3.04	No	No	0	6	7
104	R:R:I242	R:R:T150	4.56	No	No	0	8	7
105	R:R:M151	R:R:V154	7.61	No	No	0	6	6
106	R:R:I178	R:R:M151	2.92	No	No	0	6	6
107	R:R:M152	R:R:R156	12.41	No	No	0	8	9
108	R:R:M152	R:R:Y330	3.59	No	No	0	8	9
109	R:R:I242	R:R:S153	9.29	No	No	0	8	9
110	R:R:C245	R:R:S153	3.44	No	No	0	7	9
111	R:R:S153	R:R:Y246	15.26	No	Yes	0	9	8
112	R:R:D155	R:R:R170	13.1	No	No	0	8	6
113	R:R:R156	R:R:Y246	9.26	No	Yes	0	9	8
114	R:R:C161	R:R:Y157	9.41	No	Yes	5	7	7
115	R:R:H162	R:R:Y157	7.62	Yes	Yes	5	6	7
116	R:R:C245	R:R:Y157	6.72	No	Yes	0	7	7
117	R:R:L248	R:R:Y157	3.52	No	Yes	0	4	7
118	R:R:H162	R:R:I158	2.65	Yes	No	0	6	5
119	R:R:A159	R:R:R170	5.53	No	No	0	8	6
120	R:R:M249	R:R:V160	6.09	No	No	0	8	8
121	R:R:R252	R:R:V160	2.62	No	No	0	5	8
122	R:R:L253	R:R:V160	4.47	Yes	No	0	8	8
123	R:R:C161	R:R:H162	5.9	No	Yes	5	7	6
124	R:R:C161	R:R:R252	5.57	No	No	0	7	5
125	R:R:K165	R:R:V164	3.04	No	No	0	4	5
126	R:R:A166	R:R:R170	2.77	No	No	0	5	6
127	R:R:P172	R:R:T171	3.5	No	No	0	2	7
128	R:R:K174	R:R:T171	3	No	No	0	5	7
129	R:R:I177	R:R:L173	2.85	No	No	0	3	4
130	R:R:I182	R:R:N179	2.83	No	Yes	0	7	7
131	R:R:N179	R:R:W183	10.17	Yes	Yes	2	7	9
132	R:R:S188	R:R:V189	3.23	No	No	0	4	5
133	R:R:S192	R:R:V189	3.23	No	No	0	7	5
134	R:R:L196	R:R:L212	5.54	No	Yes	0	4	4
135	R:R:I208	R:R:T199	3.04	No	Yes	1	4	4
136	R:R:C210	R:R:T199	3.38	No	Yes	1	9	4
137	R:R:D204	R:R:R202	7.15	No	Yes	0	2	2
138	R:R:R202	R:R:V207	2.62	Yes	No	0	2	3
139	R:R:E209	R:R:R202	11.63	No	Yes	0	3	2
140	R:R:H304	R:R:R202	3.39	No	Yes	0	1	2
141	R:R:D204	R:R:V205	8.76	No	No	0	2	1
142	R:R:V205	R:R:V207	6.41	No	No	0	1	3
143	R:R:F214	R:R:L212	7.31	Yes	Yes	6	6	4
144	R:R:D223	R:R:L212	2.71	No	Yes	6	4	4
145	R:R:L212	R:R:M226	2.83	Yes	No	0	4	5
146	R:R:D223	R:R:F214	8.36	No	Yes	6	4	6
147	R:R:D217	R:R:D218	3.99	No	No	0	1	4
148	R:R:D218	R:R:Y219	4.6	No	No	0	4	1
149	R:R:W222	R:R:Y219	4.82	No	No	0	7	1
150	R:R:K227	R:R:V230	3.04	Yes	No	0	4	5
151	R:R:H291	R:R:K227	2.62	Yes	Yes	1	8	4
152	R:R:I294	R:R:K227	7.27	No	Yes	1	5	4
153	R:R:K227	R:R:L295	2.82	Yes	No	0	4	5
154	R:R:F231	R:R:H291	10.18	No	Yes	0	5	8
155	R:R:F231	R:R:L295	8.53	No	No	0	5	5
156	R:R:F233	R:R:I232	3.77	No	No	0	4	5
157	R:R:I232	R:R:V236	6.14	No	No	0	5	4
158	R:R:F233	R:R:I237	3.77	No	Yes	0	4	5
159	R:R:A234	R:R:H291	4.39	No	Yes	0	6	8
160	R:R:F235	R:R:V239	3.93	Yes	No	0	8	6
161	R:R:F235	R:R:F283	5.36	Yes	Yes	1	8	9
162	R:R:F235	R:R:W287	4.01	Yes	No	1	8	8
163	R:R:F235	R:R:T288	7.78	Yes	No	0	8	5
164	R:R:F235	R:R:H291	19.23	Yes	Yes	1	8	8
165	R:R:I237	R:R:V236	3.07	Yes	No	0	5	4
166	R:R:I237	R:R:P238	3.39	Yes	No	0	5	9
167	R:R:I237	R:R:I241	2.94	Yes	No	0	5	6
168	R:R:V239	R:R:V284	3.21	No	No	0	6	6
169	R:R:M249	R:R:Y246	4.79	No	Yes	0	8	8
170	R:R:V276	R:R:Y246	16.4	No	Yes	0	8	8
171	R:R:I250	R:R:T273	10.64	No	No	0	5	6
172	R:R:L253	R:R:L269	2.77	Yes	No	0	8	6
173	R:R:K254	R:R:L269	4.23	No	No	0	4	6
174	R:R:L259	R:R:V256	4.47	No	No	0	3	6
175	R:R:G261	R:R:K265	6.97	No	No	0	3	4
176	R:R:E264	R:R:R267	13.96	No	No	0	3	4
177	R:R:L269	R:R:T273	2.95	No	No	0	6	6
178	R:R:R270	R:R:R274	3.2	No	No	0	5	6
179	R:R:E335	R:R:R271	3.49	No	No	0	4	7
180	R:R:L275	R:R:L333	6.92	No	No	0	8	7
181	R:R:V279	R:R:Y330	3.79	No	No	0	8	9
182	R:R:F283	R:R:V284	2.62	Yes	No	0	9	6
183	R:R:F283	R:R:W287	9.02	Yes	No	1	9	8
184	R:R:T288	R:R:V284	3.17	No	No	0	5	6
185	R:R:C286	R:R:N322	6.3	No	Yes	0	8	9
186	R:R:N322	R:R:W287	12.43	Yes	No	0	9	8
187	R:R:I292	R:R:T288	3.04	No	No	0	5	5
188	R:R:I290	R:R:I294	2.94	Yes	No	1	6	5
189	R:R:C315	R:R:I290	3.27	No	Yes	0	7	6
190	R:R:I290	R:R:I316	2.94	Yes	Yes	1	6	5
191	R:R:E297	R:R:F293	17.49	No	Yes	0	5	5
192	R:R:A308	R:R:F293	2.77	No	Yes	0	3	5
193	R:R:F293	R:R:S311	6.61	Yes	No	0	5	4
194	R:R:F293	R:R:Y312	13.41	Yes	No	0	5	4
195	R:R:E297	R:R:V296	2.85	No	No	0	5	4
196	R:R:E297	R:R:T302	19.76	No	No	0	5	1
197	R:R:H304	R:R:L309	19.28	No	No	0	1	4
198	R:R:L309	R:R:Y313	7.03	No	No	0	4	4
199	R:R:Y312	R:R:Y313	2.98	No	No	0	4	4
200	R:R:I316	R:R:Y312	4.84	Yes	No	0	5	4
201	R:R:F314	R:R:L318	4.87	No	No	0	5	8
202	R:R:G319	R:R:N322	5.09	No	Yes	0	7	9
203	R:R:L325	R:R:T321	2.95	No	No	0	6	5
204	R:R:N322	R:R:S323	4.47	Yes	No	0	9	8
205	R:R:L325	R:R:S324	4.5	No	No	0	6	7
206	R:R:I328	R:R:L325	2.85	No	No	0	7	6
207	R:R:L329	R:R:L333	6.92	No	No	0	8	7
208	R:R:D334	R:R:N336	5.39	No	No	0	8	6
209	R:R:E335	R:R:K338	8.1	No	No	0	4	8
210	R:R:C340	R:R:F341	2.79	No	No	0	6	6
211	R:R:V83	R:R:Y87	2.52	No	No	0	8	5
212	R:R:V280	R:R:Y246	2.52	No	Yes	0	8	8
213	R:R:F82	R:R:I85	2.51	No	No	0	4	3
214	R:R:F337	R:R:I98	2.51	Yes	No	0	8	8
215	R:R:F283	R:R:I146	2.51	Yes	No	0	9	7
216	R:R:F169	R:R:I158	2.51	No	No	0	4	5
217	R:R:T63	R:R:Y119	2.5	No	Yes	0	5	4
218	R:R:F169	R:R:K174	2.48	No	No	0	4	5
219	R:R:F332	R:R:K338	2.48	No	No	0	6	8
220	R:R:I178	R:R:Y97	2.42	No	No	0	6	7
221	R:R:N268	R:R:R271	2.41	No	No	0	5	7
222	R:R:D266	R:R:R267	2.38	No	No	0	3	4
223	R:R:L107	R:R:Y140	2.34	No	Yes	0	6	5
224	R:R:G197	R:R:G198	2.11	No	No	0	4	4
225	R:R:A193	R:R:G190	1.95	No	No	0	5	6
226	R:R:C315	R:R:P289	1.88	No	No	0	7	9
227	R:R:W221	R:R:W222	1.87	No	No	0	1	7
228	R:R:G73	R:R:S324	1.86	No	No	0	8	7
229	R:R:G190	R:R:S136	1.86	No	No	0	6	5
230	R:R:G300	R:R:S301	1.86	No	No	0	2	2
231	L:L:?1	R:R:I135	1.85	Yes	No	0	0	4
232	R:R:G73	R:R:V72	1.84	No	No	0	8	5
233	R:R:G76	R:R:V75	1.84	No	No	0	7	4
234	R:R:A175	R:R:A93	1.79	No	No	0	7	6
235	R:R:P327	R:R:V80	1.77	No	No	0	9	9
236	R:R:G197	R:R:K132	1.74	No	No	0	4	6
237	R:R:G300	R:R:L299	1.71	No	No	0	2	4
238	R:R:A308	R:R:S305	1.71	No	No	0	3	3
239	R:R:G319	R:R:L318	1.71	No	No	0	7	8
240	R:R:A331	R:R:V80	1.7	No	No	0	7	9
241	R:R:A57	R:R:I58	1.62	No	No	0	4	4
242	R:R:A175	R:R:I96	1.62	No	Yes	0	7	5
243	R:R:A298	R:R:K227	1.61	No	Yes	0	4	4
244	R:R:V278	R:R:V282	1.6	No	No	0	5	7
245	R:R:A298	R:R:L224	1.58	No	No	0	4	3
246	R:R:I61	R:R:V60	1.54	No	No	0	5	5
247	R:R:I61	R:R:V65	1.54	No	No	0	5	5
248	R:R:A93	R:R:D155	1.54	No	No	0	6	8
249	R:R:I194	R:R:V195	1.54	Yes	No	0	4	4
250	R:R:I208	R:R:V201	1.54	No	No	0	4	2
251	R:R:I243	R:R:V239	1.54	No	No	0	5	6
252	R:R:I243	R:R:V280	1.54	No	No	0	5	8
253	R:R:H162	R:R:P163	1.53	Yes	No	0	6	8
254	R:R:L101	R:R:S145	1.5	No	No	4	9	9
255	R:R:L149	R:R:S145	1.5	No	No	4	8	9
256	R:R:L79	R:R:V80	1.49	No	No	0	6	9
257	R:R:L130	R:R:V129	1.49	Yes	No	0	5	1
258	R:R:L196	R:R:V195	1.49	No	No	0	4	4
259	R:R:L240	R:R:V244	1.49	No	No	0	3	4
260	R:R:L248	R:R:V244	1.49	No	No	0	4	4
261	R:R:L253	R:R:V256	1.49	Yes	No	0	8	6
262	R:R:L275	R:R:V276	1.49	No	No	0	8	8
263	R:R:L275	R:R:V279	1.49	No	No	0	8	8
264	R:R:L333	R:R:V278	1.49	No	No	0	7	5
265	R:R:L329	R:R:V279	1.49	No	No	0	8	8
266	R:R:L329	R:R:V282	1.49	No	No	0	8	7
267	R:R:I191	R:R:I194	1.47	No	Yes	0	4	4
268	R:R:D266	R:R:S262	1.47	No	No	0	3	1
269	R:R:F214	R:R:P215	1.44	Yes	No	0	6	5
270	R:R:E203	R:R:V201	1.43	No	No	0	1	2
271	R:R:I272	R:R:L253	1.43	No	Yes	0	7	8
272	R:R:I272	R:R:L259	1.43	No	No	0	7	3
273	R:R:L224	R:R:L299	1.38	No	No	0	3	4
274	R:R:L258	R:R:L259	1.38	No	No	0	5	3
275	R:R:P125	R:R:W124	1.35	No	Yes	0	1	8
276	R:R:F214	R:R:S211	1.32	Yes	No	0	6	4
277	R:R:F70	R:R:V71	1.31	Yes	No	0	7	5
278	R:R:H162	R:R:K165	1.31	Yes	No	0	6	4
279	R:R:E264	R:R:N268	1.31	No	No	0	3	5
280	R:R:F225	R:R:I228	1.26	No	No	0	4	5
281	R:R:I62	R:R:Y119	1.21	No	Yes	0	5	4
282	R:R:D334	R:R:R156	1.19	No	No	0	8	9
283	R:R:D168	R:R:F169	1.19	No	No	0	4	4
284	R:R:I180	R:R:W183	1.17	No	Yes	0	4	9
285	R:R:R86	R:R:Y87	1.03	No	No	0	5	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	7.61333	12	1	0
2	R:R:F70	6.748	5	1	7
3	R:R:N77	3.8675	4	3	9
4	R:R:I96	4.164	5	0	5
5	R:R:D105	3.96	4	3	9
6	R:R:T111	3.4475	4	1	7
7	R:R:M112	9.5475	4	1	7
8	R:R:F114	4.09	4	1	5
9	R:R:Y119	4.105	4	0	4
10	R:R:W124	6.87857	7	1	8
11	R:R:F126	6.3	4	1	7
12	R:R:L130	3.52	4	1	5
13	R:R:Y139	5.1925	4	1	5
14	R:R:Y140	5.824	5	2	5
15	R:R:T144	5.0025	4	2	7
16	R:R:Y157	6.8175	4	5	7
17	R:R:H162	3.802	5	5	6
18	R:R:N179	8.425	4	2	7
19	R:R:W183	8.784	5	2	9
20	R:R:I194	3.39	4	0	4
21	R:R:T199	4.51	4	1	4
22	R:R:R202	6.1975	4	0	2
23	R:R:L212	4.5975	4	6	4
24	R:R:F214	4.6075	4	6	6
25	R:R:K227	4.11333	6	1	4
26	R:R:F235	8.062	5	1	8
27	R:R:I237	3.2925	4	0	5
28	R:R:Y246	9.646	5	0	8
29	R:R:L253	2.54	4	0	8
30	R:R:F283	4.8775	4	1	9
31	R:R:I290	2.9825	4	1	6
32	R:R:H291	8.118	5	1	8
33	R:R:F293	10.07	4	0	5
34	R:R:I316	4.7075	4	1	5
35	R:R:Y320	8.638	5	1	6
36	R:R:N322	7.0725	4	0	9
37	R:R:F337	3.8475	4	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:I316	67.2131	5.56	Yes	Yes	1	0	5
2	R:R:I316	R:R:Y312	70.6041	4.84	Yes	No	0	5	4
3	R:R:Y312	R:R:Y313	49.1803	2.98	No	No	0	4	4
4	R:R:Y119	R:R:Y313	17.4152	9.93	Yes	No	0	4	4
5	L:L:?1	R:R:Y320	96.0364	13.7	Yes	Yes	1	0	6
6	R:R:M112	R:R:Y320	19.0097	10.78	Yes	Yes	1	7	6
7	R:R:F70	R:R:M112	10.9926	11.2	Yes	Yes	1	7	7
8	R:R:V108	R:R:Y320	85.055	3.79	No	Yes	0	7	6
9	R:R:S323	R:R:V108	47.2266	3.23	No	No	0	8	7
10	R:R:D105	R:R:S323	46.0925	5.89	Yes	No	0	9	8
11	R:R:D105	R:R:P327	13.7997	3.22	Yes	No	3	9	9
12	R:R:P327	R:R:V80	14.3611	1.77	No	No	0	9	9
13	R:R:D105	R:R:N77	28.6661	2.69	Yes	Yes	3	9	9
14	R:R:A102	R:R:N77	28.6661	3.13	No	Yes	0	8	9
15	R:R:A102	R:R:M81	27.532	3.22	No	No	0	8	7
16	R:R:F99	R:R:M81	27.0155	4.98	No	No	0	5	7
17	L:L:?1	R:R:H291	85.7624	4.17	Yes	Yes	1	0	8
18	R:R:F235	R:R:H291	100	19.23	Yes	Yes	1	8	8
19	R:R:F235	R:R:V239	88.2888	3.93	Yes	No	0	8	6
20	R:R:I243	R:R:V239	88.3786	1.54	No	No	0	5	6
21	R:R:I243	R:R:V280	87.2446	1.54	No	No	0	5	8
22	R:R:V280	R:R:Y246	86.5147	2.52	No	Yes	0	8	8
23	R:R:R156	R:R:Y246	43.6335	9.26	No	Yes	0	9	8
24	R:R:M152	R:R:R156	39.4341	12.41	No	No	0	8	9
25	R:R:M152	R:R:Y330	38.2102	3.59	No	No	0	8	9
26	R:R:I98	R:R:Y330	43.117	3.63	No	No	0	8	9
27	R:R:F337	R:R:I98	42.1401	2.51	Yes	No	0	8	8
28	R:R:N141	R:R:V108	61.2958	11.82	No	No	0	8	7
29	R:R:A104	R:R:N141	59.0725	3.13	No	No	0	8	8
30	R:R:A104	R:R:T144	57.0402	3.36	No	Yes	0	8	7
31	R:R:T144	R:R:W183	47.3613	9.7	Yes	Yes	2	7	9
32	R:R:N179	R:R:W183	42.623	10.17	Yes	Yes	2	7	9
33	R:R:I96	R:R:N179	46.5417	7.08	Yes	Yes	0	5	7
34	R:R:I96	R:R:M90	42.8475	2.92	Yes	No	0	5	7
35	R:R:I84	R:R:M90	55.85	4.37	No	No	0	7	7
36	R:R:F337	R:R:I84	47.9901	3.77	Yes	No	0	8	7
37	R:R:F99	R:R:M90	26.5551	4.98	No	No	0	5	7
38	R:R:F337	R:R:V83	25.713	2.62	Yes	No	0	8	8
39	R:R:I84	R:R:N95	11.6438	2.83	No	No	0	7	7
40	R:R:V83	R:R:Y87	17.2805	2.52	No	No	0	8	5
41	R:R:R86	R:R:Y87	12.9912	1.03	No	No	0	5	5
42	R:R:S153	R:R:Y246	50.932	15.26	No	Yes	0	9	8
43	R:R:C245	R:R:S153	46.4631	3.44	No	No	0	7	9
44	R:R:C245	R:R:Y157	43.9142	6.72	No	Yes	0	7	7
45	R:R:H162	R:R:Y157	30.3391	7.62	Yes	Yes	5	6	7
46	R:R:H162	R:R:I158	20.649	2.65	Yes	No	0	6	5
47	R:R:F169	R:R:I158	17.7184	2.51	No	No	0	4	5
48	R:R:F169	R:R:K174	11.7898	2.48	No	No	0	4	5
49	R:R:I96	R:R:Y97	11.7337	4.84	Yes	No	0	5	7
50	R:R:N100	R:R:T148	10.768	4.39	No	No	0	9	7
51	R:R:T111	R:R:Y320	19.7956	4.99	Yes	Yes	1	7	6
52	R:R:F114	R:R:T111	12.34	2.59	Yes	Yes	1	5	7
53	L:L:?1	R:R:V118	36.8852	2.9	Yes	No	1	0	5
54	R:R:V118	R:R:W124	39.0074	3.68	No	Yes	1	5	8
55	R:R:F126	R:R:W124	10.4649	9.02	Yes	Yes	1	7	8
56	R:R:L309	R:R:Y313	30.1819	7.03	No	No	0	4	4
57	R:R:H304	R:R:L309	27.2288	19.28	No	No	0	1	4
58	R:R:H304	R:R:R202	24.2533	3.39	No	Yes	0	1	2
59	R:R:R202	R:R:V207	12.4186	2.62	Yes	No	0	2	3
60	L:L:?1	R:R:Y139	46.1262	7.61	Yes	Yes	1	0	5
61	R:R:A193	R:R:Y139	43.903	2.67	No	Yes	0	5	5
62	R:R:A193	R:R:G190	41.5787	1.95	No	No	0	5	6
63	R:R:G190	R:R:S136	38.9288	1.86	No	No	0	6	5
64	R:R:I194	R:R:S136	36.2565	6.19	Yes	No	0	4	5
65	L:L:?1	R:R:K227	21.3227	7.32	Yes	Yes	1	0	4
66	R:R:K227	R:R:V230	18.7514	3.04	Yes	No	0	4	5
67	R:R:F143	R:R:V230	16.1352	2.62	No	No	0	6	5
68	R:R:F235	R:R:F283	16.2699	5.36	Yes	Yes	1	8	9
69	R:R:F283	R:R:I146	25.567	2.51	Yes	No	0	9	7
70	R:R:I146	R:R:P238	24.3207	3.39	No	No	0	7	9
71	R:R:P238	R:R:T150	15.8882	3.5	No	No	0	9	7
72	R:R:I237	R:R:P238	16.2475	3.39	Yes	No	0	5	9
73	R:R:I242	R:R:T150	18.6167	4.56	No	No	0	8	7
74	R:R:A175	R:R:I96	17.3815	1.62	No	Yes	0	7	5
75	R:R:A175	R:R:A93	14.4958	1.79	No	No	0	7	6
76	R:R:A93	R:R:D155	11.5877	1.54	No	No	0	6	8
77	R:R:M249	R:R:Y246	36.1779	4.79	No	Yes	0	8	8
78	R:R:M249	R:R:V160	33.9434	6.09	No	No	0	8	8
79	R:R:L253	R:R:V160	29.0029	4.47	Yes	No	0	8	8
80	R:R:I194	R:R:V195	22.5578	1.54	Yes	No	0	4	4
81	R:R:L196	R:R:V195	19.7507	1.49	No	No	0	4	4
82	R:R:L196	R:R:L212	16.9212	5.54	No	Yes	0	4	4
83	R:R:F235	R:R:W287	21.3002	4.01	Yes	No	1	8	8
84	R:R:V276	R:R:Y246	19.616	16.4	No	Yes	0	8	8
85	R:R:L253	R:R:L269	10.5547	2.77	Yes	No	0	8	6
86	R:R:L275	R:R:V276	18.2012	1.49	No	No	0	8	8
87	R:R:L275	R:R:L333	11.0824	6.92	No	No	0	8	7
88	R:R:N322	R:R:W287	32.8093	12.43	Yes	No	0	9	8
89	R:R:N322	R:R:S323	31.8549	4.47	Yes	No	0	9	8
90	R:R:F293	R:R:Y312	21.3339	13.41	Yes	No	0	5	4
91	R:R:G319	R:R:N322	10.9364	5.09	No	Yes	0	7	9
92	R:R:A298	R:R:K227	13.227	1.61	No	Yes	0	4	4
93	R:R:A298	R:R:L224	10.8578	1.58	No	No	0	4	3
94	R:R:H291	R:R:K227	14.7541	2.62	Yes	Yes	1	8	4
95	R:R:F283	R:R:W287	12.7105	9.02	Yes	No	1	9	8
96	R:R:I242	R:R:S153	17.8868	9.29	No	No	0	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:Q115	6.91	1	Yes	No	0	7	0	1
L:L:?1	R:R:V118	2.9	1	Yes	No	0	5	0	1
L:L:?1	R:R:D138	22.9	1	Yes	No	0	6	0	1
L:L:?1	R:R:Y139	7.61	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:M142	9.18	1	Yes	No	0	7	0	1
L:L:?1	R:R:K227	7.32	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:I290	2.78	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:H291	4.17	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:I294	6.48	1	Yes	No	0	5	0	1
L:L:?1	R:R:I316	5.56	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:Y320	13.7	1	Yes	Yes	0	6	0	1
R:R:M112	R:R:Y66	7.18	1	Yes	No	7	6	2	2
R:R:Y320	R:R:Y66	9.93	1	Yes	No	6	6	1	2
R:R:V108	R:R:Y320	3.79	0	No	Yes	7	6	2	1
R:R:T111	R:R:Y320	4.99	1	Yes	Yes	7	6	2	1
R:R:M112	R:R:Y320	10.78	1	Yes	Yes	7	6	2	1
R:R:Q115	R:R:V118	4.3	1	No	No	7	5	1	1
R:R:I316	R:R:Q115	5.49	1	Yes	No	5	7	1	1
R:R:V118	R:R:W124	3.68	1	No	Yes	5	8	1	2
R:R:D138	R:R:Y139	6.9	1	No	Yes	6	5	1	1
R:R:M142	R:R:Y139	3.59	1	No	Yes	7	5	1	1
R:R:A193	R:R:Y139	2.67	0	No	Yes	5	5	2	1
R:R:K227	R:R:V230	3.04	1	Yes	No	4	5	1	2
R:R:H291	R:R:K227	2.62	1	Yes	Yes	8	4	1	1
R:R:I294	R:R:K227	7.27	1	No	Yes	5	4	1	1
R:R:K227	R:R:L295	2.82	1	Yes	No	4	5	1	2
R:R:F231	R:R:H291	10.18	0	No	Yes	5	8	2	1
R:R:F231	R:R:L295	8.53	0	No	No	5	5	2	2
R:R:A234	R:R:H291	4.39	0	No	Yes	6	8	2	1
R:R:F235	R:R:H291	19.23	1	Yes	Yes	8	8	2	1
R:R:I290	R:R:I294	2.94	1	Yes	No	6	5	1	1
R:R:C315	R:R:I290	3.27	0	No	Yes	7	6	2	1
R:R:I290	R:R:I316	2.94	1	Yes	Yes	6	5	1	1
R:R:I316	R:R:Y312	4.84	1	Yes	No	5	4	1	2
L:L:?1	R:R:I135	1.85	1	Yes	No	0	4	0	1
R:R:A298	R:R:K227	1.61	0	No	Yes	4	4	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9D61_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.54
Number of Linked Nodes	254
Number of Links	285
Number of Hubs	37
Number of Links mediated by Hubs	143
Number of Communities	6
Number of Nodes involved in Communities	47
Number of Links involved in Communities	65

Path Summary
Number Of Nodes in MetaPath	97
Number Of Links MetaPath	96
Number of Shortest Paths	31565
Length Of Smallest Path	3
Average Path Length	12.1408
Length of Longest Path	27
Minimum Path Strength	1.38
Average Path Strength	5.65559
Maximum Path Strength	18.625
Minimum Path Correlation	0.7
Average Path Correlation	0.921633
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.16667
Average % Of Corr. Nodes	49.7616
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	39.2259
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • synapse • cell junction • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • neuropeptide binding • peptide binding • peptide receptor activity • molecular transducer activity • G protein-coupled opioid receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • G protein-coupled peptide receptor activity • dynorphin receptor activity • receptor serine/threonine kinase binding • signaling receptor binding • ovulation cycle • rhythmic process • estrous cycle • reproductive process • multicellular organismal reproductive process • G protein-coupled opioid receptor signaling pathway • trans-synaptic signaling • anterograde trans-synaptic signaling • chemical synaptic transmission • behavior • learning • learning or memory • cognition • conditioned place preference • associative learning • biological process involved in interspecies interaction between organisms • defense response to virus • defense response • response to other organism • response to stress • response to external stimulus • response to external biotic stimulus • response to virus • response to biotic stimulus • response to acrylamide • neuropeptide signaling pathway • locomotory behavior • adult behavior • behavioral response to cocaine • response to cocaine • response to alkaloid • response to estrogen • immune response • immune system process • homeostatic process • cellular response to glucose stimulus • intracellular glucose homeostasis • response to hexose • cellular response to carbohydrate stimulus • cellular homeostasis • response to monosaccharide • response to carbohydrate • chemical homeostasis • response to glucose • glucose homeostasis • carbohydrate homeostasis • cellular response to hexose stimulus • intracellular chemical homeostasis • cellular response to monosaccharide stimulus • maternal behavior • parental behavior • reproductive behavior • regulation of localization • negative regulation of luteinizing hormone secretion • regulation of system process • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • regulation of luteinizing hormone secretion • luteinizing hormone secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • regulation of biological quality • regulation of hormone levels • establishment of localization • regulation of secretion • endocrine hormone secretion • negative regulation of gonadotropin secretion • negative regulation of multicellular organismal process • regulation of endocrine process • regulation of hormone secretion • gonadotropin secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • secretion by cell • regulation of secretion by cell • signal release • negative regulation of cellular process • regulation of multicellular organismal process • regulation of signaling • secretion • regulation of transport • regulation of gonadotropin secretion • export from cell • endocrine process • hormone transport • regulation of cell communication • eating behavior • feeding behavior • sensory perception of temperature stimulus • cellular response to lipopolysaccharide • cellular response to molecule of bacterial origin • response to lipopolysaccharide • cellular response to biotic stimulus • response to bacterium • response to molecule of bacterial origin • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-inhibiting opioid receptor signaling pathway • monoamine transport • nitrogen compound transport • regulation of catecholamine secretion • positive regulation of biological process • organic hydroxy compound transport • positive regulation of secretion by cell • dopamine transport • positive regulation of amine transport • catecholamine transport • positive regulation of secretion • positive regulation of cellular process • positive regulation of catecholamine secretion • dopamine secretion • positive regulation of dopamine secretion • catecholamine secretion • amine transport • positive regulation of transport • regulation of amine transport • regulation of dopamine secretion • regulation of body fluid levels • secretion by tissue • digestive system process • regulation of digestive system process • body fluid secretion • digestion • saliva secretion • regulation of saliva secretion • response to ethanol • response to peptide hormone • response to insulin • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • p38MAPK cascade • positive regulation of response to stimulus • regulation of intracellular signal transduction • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • positive regulation of p38MAPK cascade • regulation of response to stimulus • regulation of p38MAPK cascade • MAPK cascade • positive regulation of signaling • regulation of eating behavior • positive regulation of feeding behavior • positive regulation of eating behavior • regulation of behavior • positive regulation of behavior • positive regulation of multicellular organismal process • regulation of feeding behavior • sensory perception of pain • response to nicotine • positive regulation of cation transmembrane transport • regulation of potassium ion transport • monoatomic ion transmembrane transport • potassium ion transmembrane transport • regulation of monoatomic ion transmembrane transport • metal ion transport • monoatomic cation transmembrane transport • positive regulation of monoatomic ion transport • positive regulation of transmembrane transport • monoatomic ion transport • positive regulation of monoatomic ion transmembrane transport • monoatomic cation transport • regulation of metal ion transport • regulation of monoatomic ion transport • regulation of potassium ion transmembrane transport • transmembrane transport • positive regulation of potassium ion transport • regulation of transmembrane transport • positive regulation of potassium ion transmembrane transport • regulation of monoatomic cation transmembrane transport • potassium ion transport • postsynapse • postsynaptic membrane • plasma membrane region • synaptic membrane • sarcolemma • T-tubule • somatodendritic compartment • cell body • perikaryon • neuronal cell body • presynapse • presynaptic membrane • dendrite • dendritic tree • sarcoplasm • endoplasmic reticulum • sarcoplasmic reticulum • intracellular vesicle • transport vesicle membrane • cytoplasmic vesicle • vesicle membrane • synaptic vesicle • synaptic vesicle membrane • transport vesicle • exocytic vesicle membrane • cytoplasmic vesicle membrane • secretory vesicle • exocytic vesicle • mitochondrion • axon • axon terminus • distal axon • neuron projection terminus
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	JDC
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	JDC
Name	(3R)-7-hydroxy-N-{(2S)-1-[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]-3-methylbutan-2-yl}-1,2,3,4-tetrahydroisoquinoline-3-carboxamide
Synonyms
Identifier
Formula	C28 H39 N3 O3
Molecular Weight	465.628
SMILES
PubChem	9956146
Formal Charge	0
Total Atoms	73
Total Chiral Atoms	4
Total Bonds	76
Total Aromatic Bonds	12


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P41145
Sequence	>9D61_nogp_Chain_R A I P V I I T A V Y S V V F V V G L V G N S L V M F V I I R Y T K M K T A T N I Y I F N L A L A D A L V T T T M P F Q S T V Y L M N S W P F G D V L C K I V I S I D Y Y N M F T S I F T L T M M S V D R Y I A V C H P V K A L D F R T P L K A K I I N I C I W L L S S S V G I S A I V L G G T K V R E D V D V I E C S L Q F P D D D Y S W W D L F M K I C V F I F A F V I P V L I I I V C Y T L M I L R L K S V R L L S G S R E K D R N L R R I T R L V L V V V A V F V V C W T P I H I F I L V E A L G S T S H S T A A L S S Y Y F C I A L G Y T N S S L N P I L Y A F L D E N F K R C F R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6B73	A	Peptide	Opioid	κ	Homo sapiens	MP1104	-	-	3.1	2018-01-17	doi.org/10.1016/j.cell.2017.12.011
	8F7W	A	Peptide	Opioid	κ	Homo sapiens	Dynorphin	-	Gi1/β1/γ2	3.19	2022-12-14	doi.org/10.1016/j.cell.2022.12.026
	8F7W (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	Dynorphin	-		3.19	2022-12-14	doi.org/10.1016/j.cell.2022.12.026
	4DJH	A	Peptide	Opioid	κ	Homo sapiens	JDTic	-	-	2.9	2012-03-21	doi.org/10.1038/nature10939
	6VI4	A	Peptide	Opioid	κ	Homo sapiens	JDTic	-	-	3.3	2020-03-18	doi.org/10.1038/s41467-020-14889-7
	7YIT	A	Peptide	Opioid	κ	Homo sapiens	Nalfurafine	-	-	3.3	2023-04-12	doi.org/10.1038/s41467-023-37041-7
	8FEG	A	Peptide	Opioid	κ	Homo sapiens	(DNCP)-β-Naloxamine	-	Gi1/β1/γ2	2.54	2023-12-06	doi.org/10.1038/s41467-023-43718-w
	8FEG (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	(DNCP)-β-Naloxamine	-		2.54	2023-12-06	doi.org/10.1038/s41467-023-43718-w
	8DZP	A	Peptide	Opioid	κ	Homo sapiens	momSalB	-	Gi1/β1/γ2	2.71	2023-05-03	doi.org/10.1038/s41586-023-06030-7
	8DZP (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	momSalB	-		2.71	2023-05-03	doi.org/10.1038/s41586-023-06030-7
	8DZQ	A	Peptide	Opioid	κ	Homo sapiens	momSalB	-	Go/β1/γ2	2.82	2023-05-03	doi.org/10.1038/s41586-023-06030-7
	8DZQ (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	momSalB	-		2.82	2023-05-03	doi.org/10.1038/s41586-023-06030-7
	8DZR	A	Peptide	Opioid	κ	Homo sapiens	GR89,696	-	chim(NtGi2-Gt3)/β1/γ2	2.61	2023-05-03	doi.org/10.1038/s41586-023-06030-7
	8DZR (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	GR89,696	-		2.61	2023-05-03	doi.org/10.1038/s41586-023-06030-7
	8DZS	A	Peptide	Opioid	κ	Homo sapiens	GR89,696	-	chim(NtGi2-Gz)/β1/γ2	2.65	2023-05-03	doi.org/10.1038/s41586-023-06030-7
	8DZS (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	GR89,696	-		2.65	2023-05-03	doi.org/10.1038/s41586-023-06030-7
	7Y1F	A	Peptide	Opioid	κ	Homo sapiens	Dynorphin	-	Gi1/β1/γ2	3.3	2023-05-24	doi.org/10.1093/procel/pwac033
	7Y1F (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	Dynorphin	-		3.3	2023-05-24	doi.org/10.1093/procel/pwac033
	9MQK	A	Peptide	Opioid	κ	Homo sapiens	Isoquinuclidine	-	-	3.18	2025-02-12	doi.org/10.1101/2025.01.09.632033
	9MQL	A	Peptide	Opioid	κ	Homo sapiens	Isoquinuclidine	-	-	2.96	2025-02-12	doi.org/10.1101/2025.01.09.632033
	8VVE	A	Peptide	Opioid	κ	Homo sapiens	norBNI	-	Gi1/β1/γ2	3.3	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	8VVE (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	norBNI	-		3.3	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	8VVF	A	Peptide	Opioid	κ	Homo sapiens	JDTic	-	Gi1/β1/γ2	3	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	8VVF (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	JDTic	-		3	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	8VVG	A	Peptide	Opioid	κ	Homo sapiens	GB18	-	Gi1/β1/γ2	3.3	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	8VVG (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	GB18	-		3.3	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	9D61	A	Peptide	Opioid	κ	Homo sapiens	JDTic	-	Gi1/β1/γ2	3.58	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	9D61 (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	JDTic	-		3.58	2025-01-15	doi.org/10.1038/s41589-024-01812-0

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